Dissertationen zum Thema „Vegfc“
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Penco-Campillo, Manon. „Le VEGFC et les récepteurs CXCR1/2 : des cibles pertinentes pour le traitement des médulloblastomes pédiatriques“. Electronic Thesis or Diss., Université Côte d'Azur, 2022. http://www.theses.fr/2022COAZ6025.
Der volle Inhalt der QuelleMedulloblastoma (MB) is the most common and aggressive pediatric brain tumor. Despite aggressive multimodal treatment, resulting in significant side effects, 30% of patients develop resistance and relapse following the appearance of metastases within 5 years. Recurrences cannot be controlled by conventional (radio- and chemotherapy) or targeted (anti-angiogenic, anti-inflammatory, anti-immune checkpoint) treatments. The objective of my thesis is therefore to discover new targets and relevant therapeutic strategies for these patients at diagnosis or after a relapse.MBs are highly vascularized tumors. The phenomenon of resistance is, in part, linked to the development of blood (angiogenesis) and lymphatic (lymphangiogenesis) vessels in the tumor, which constitute the main routes of metastatic dissemination. The lymphatic growth factor, VEGFC, and its receptors/co-receptors are the major players in lymphangiogenesis. In the first part of my thesis, I showed that VEGFC is inversely correlated to MB cell growth and aggressiveness. Indeed, VEGFC decreases the proliferation and migration of MB cells, as well as their ability to form pseudo-vessels in vitro, by an autocrine signalization. Cells resistant to radiotherapy show elevated levels of VEGFC and lose their ability to migrate and form pseudo-vessels. Irradiation reduces the aggressiveness of MB cells by a VEGFC-dependent process. VEGFC-overexpressing cells and radiation-resistant cells form smaller experimental tumors in nude mice. Thus, VEGC appears to be a negative regulator of MB growth. These results pave the way for the development of pro-VEGFC therapies in these cancers.In the second part of my thesis, I correlated the expression of the ELR+CXCL/CXCR1-2 pro-angiogenic and pro-inflammatory signaling pathway to shorter survival in patients with MB. I showed that a novel pharmacological inhibitor (C29) of CXCR1-2 receptors inhibits proliferation, CXCL8/CXCR1-2-dependent migration, invasion and pseudo-vessel formation by susceptible or resistant MB cells to radiotherapy. C29 reduces the growth of experimental MBs in an ex vivo organotypic mouse model and crosses the blood-brain barrier. Thus, targeting CXCR1-2 represents a promising strategy for the treatment of pediatric MB, at first line or at relapse.Key words: pediatric medulloblastoma, VEGFC/VEGFR, CXCR1-2, ELR+CXCL cytokines, targeted therapy, lymphangiogenesis, angiogenesis
Decio, Alessandra Agnese. „The VEGFC/VEGFR3 pathway in the malignancy of ovarian carcinoma“. Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606839.
Der volle Inhalt der QuelleFerrão, Juliana Shimara Pires. „Tratamento com VEGFC para revascularização linfática em membros pélvicos de camundongos“. Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08012014-112630/.
Der volle Inhalt der QuelleLymphatic revascularization is a challenge and the establishment of new therapeutic strategies may improve quality of life from those suffering from lymphatic disorders. The objective of this study was to verify the VEGFC treatment capacity in improving lymphatic vascularization in a time-dependent manner in mouse hind limb (HL) after removal of inguinal lymphnode. The left inguinal lymphnode was surgically removed to mimetize pathologies with decreased lymphatic vascularization. Lymphatic vascular density (Vv) and length (Lv) were evaluated by immunohistochemistry followed by stereology after surgery and/or VEGFC treatment. Control group was not manipulated but received saline instead of VEGFC treatment. VEGFC and FLT4 local expression were assessed by qPCR. There was effect of time over Vv and Lv in the SG and significant difference between CG and SG in the three studied regions (proximal, medium and distal region) of the left HL (LHL). The Lv showed significant difference between CG and SG only in the medium region. The Vv and the Lv for TG were higher than the other groups in all regions of LHL. VEGFC and FLT4 gene expression presented time effect in all regions of the LHL for SG and TG. Both VEGFC and FLT4 gene expression presented significant difference between CG and SG, between SG and TG, and between CG and TG. The results show that mice are good experimental models for VEGFC use as therapy for lymphatic revascularization, and VEGFC treatment increased the lymphatic vasculature already after 3 days of lymphatic damage.
Dellinger, Mike. „Contrasting Defects in Lymphangiogenic Remodeling and Lymphangiogenesis Revealed in Angiopoietin-2 Deficient and Vegfc Hemizygous Mice“. Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195639.
Der volle Inhalt der QuelleMatsumura, Kazuyoshi. „Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3“. Kyoto University, 2003. http://hdl.handle.net/2433/148461.
Der volle Inhalt der QuelleSilva, Luciana Oliveira da. „Expressão do fator de crescimento endotelial vascular (VEGF) e seus receptores VEGFR-1 e VEGFR-2 durante o início da gestação em camundongos“. Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-09092008-114452/.
Der volle Inhalt der QuelleIn rodents, increase of vascular permeability, decidual cell transformation, and uterine angiogenesis are crucial events for the success of pregnancy. Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells and an inducer of angiogenesis. VEGF acts via two tyrosine kinase family receptors: VEGFR1 and VEGFR2. The aim of this study was to investigate using the immunohistochemical method, the spatiotemporal expression of VEGF and its receptors VEGFR1 e VEGFR2 by mouse endometrial cells on days 4 to 8 of pregnancy. On day 4, VEGF, VEGFR1 and VEGFR2 were expressed mostly by the luminal and glandular epithelium. Stromal cells showed a very weak labeling. On days 5-8, VEGF and its receptors showed an increased labeling throughout the mesometrial decidua. The expression of VEGF, VEGFR1, and VEGFR2 were differentially expressed in the mesometrial cells and in the predecidual cells of the antimesometrial decidua. VEGFR1 and VEGF R2 were highly expressed by endothelial cells of the mesometrial sinusoids, and Nk uterine cells.
Kranich, Sandra [Verfasser]. „Effekte der Wachstumsfaktoren VEGF-C und VEGF-D und Signaltransduktion des Rezeptors VEGFR-3 in Zellen des zentralen Nervensystems / Sandra Kranich“. Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019868597/34.
Der volle Inhalt der QuelleReille-Seroussi, Marie. „Système VEGF/VEGFR : conception et évaluation de molécules ciblées et régulation potentielle par les métaux“. Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P614/document.
Der volle Inhalt der QuelleInhibiting angiogenesis is an effective strategy of targeting therapy against cancer. In thiscontext, we develop an antiangiogenic strategy consisting in the design and evaluation of compoundsblocking the VEGF/VEGFR interaction. The first approach was the conception of antagonists of theVEGFR1. Starting from a (3-carboxy-2-ureido) thiophene hit, a variety of heterocyclic analogs wasdeveloped. Interesting chemical observations were made during the synthesis, but no optimization ofthe biochemical activity was achieved. The second approach was the design of peptides that bind tothe receptor-recognition surface of the VEGF. Starting from a cyclic peptide known to bind to theVEGF with a sub-micromolar affinity, new peptides and peptidomimetics were developed. Thestrategy was to design simplified and potentially more stable compounds, and to improve at thesame time the VEGF affinity. The interaction of VEGF with these ligands was studied in vitro by ELISAand ITC experiments, as well as X-ray diffraction for the best compound. Moreover, the investigationof the effects of copper and other divalent metals on the VEGF/VEGFR1 interaction was undertaken.Experiments realized in the laboratory and in collaboration showed that metals were able to displacethe VEGF/VEGFR1 interaction and to induce the dimerisation of the domain 2 of the receptor. Metalsare well known to play an important role in angiogenic phenomena, but their specific targets are stilla matter of debate. In this context, this discovery brings new response elements regarding theirmechanisms of action. Therefore, the objectives of this PhD thesis were the development of newantiangiogenic compounds, as well as the understanding of some aspects of the regulation of angiogenesis
Olofsson, Birgitta. „Studies of the vascular endothelial growth factors, VEGFs, and their receptors, focusing on VEGF-B /“. Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3633-1/.
Der volle Inhalt der QuelleHomman, Ludiye Jihane. „Rôle et expression du facteur lymphangiogénique VEGF-C et de son récepteur VEGFR-3 au cours du développement du cerveau embryonnaire“. Paris 6, 2008. http://www.theses.fr/2008PA066052.
Der volle Inhalt der QuelleGonçalves, Silvana Beltrami. „Efeito do VEGF na angiogênese pulpar e na apoptose“. Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/25/25138/tde-22062007-094740/.
Der volle Inhalt der QuelleThe Vascular endothelial growth factor (VEGF) plays na important role in angiogenesis by inducing endothelial cell proliferation, migration, and survival. To promote new vessel formation and improve collateral circulation, VEGF has been used to treat ischemic heart areas in cardiovascular disease. Maintenance of pulp vitality with VEGF may improve the outcomes of avulsed teeth, preventing premature tooth loss. The purpose of this study was to develop a model system to study the process of dental pulp revascularization, and assess the effect of VEGF-165 in the human pulp angiogenesis and apoptosis. Human tooth slices were maintained in vitro for 7 days +/- VEGF (50ng/mL). Immunohistochemistry staining for Von Willebrand?s factor (Factor VIII) was used to quantify the number of vessels in pulp tissues. There was a significantly higher number of blood vessels in the VEGF group (67.8 Mean) compared to the control group (46.2 Mean, p<0.05). Tunel Assay was used to determine the number of apoptotic cells in +/- VEGF groups. RTPCR analyses of VEGFR-2 transcripts were used on human dermal microvascular endothelial cells (HDMECs), undifferentiated pulp cells (OD-21), mouse odontoblast-like cells (MDPC-23), and macrophages. VEGFR-2 expression was detected in HDMECs but not in the other 3 cell lines. Four tooth slices per mouse were subcutaneously implanted in the dorsal region for 7 days. Pulp vitality was determined by histological and immunohistochemical analysis. Also, Tunel Assay was used to determine the number of apoptotic cells. SCID mouse model of pulp angiogenesis demonstrated to be a good model system to study revascularization of human dental pulps. Taking into account the findings of this study, it is suggested that VEGF could have a positive effect in the revascularization of avulsed teeth. It is hoped that this pulp angiogenesis model be useful to answer a number of new experimental questions in the area of Endodontics.
Sentilhes, Loïc. „Etudes in vivo de l'ontogénèse des systèmes VEGF/ VEGFR-2 et fibrinolytiques et applications à l'ischémie cérébrale périnatale“. Rouen, 2010. http://www.theses.fr/2010ROUENR01.
Der volle Inhalt der QuelleThe objectives were (i) to investigate the temporo-spatial distribution of the VEGUVEGFR-2 signalling pathway in the human forebrain and cerebellum and in the human ischemic forebrain at several developmental stages; (ii) to compare the fibrinolytic system at birth of extremely preterm, very preterm, and moderately preterm neonates to that of full-term neonates. The results showed that (i) VEGF is involved in several aspects of neural cell development -migration, differentiation, synaptogenesis and myelination - and that VEGFR-2 might be one of the main receptors that médiate these properties; (ii) VEGF plays roles which are unlikely to be mediated by VEGFR-2 in the human forebrain régions exposed to ischemia during the pré- and neonatal period; (iii) the development within 10 days alter the birth of extremely preterm infants of fibrinolysis suppression, which may contribute te, the increased risk of periventricular hemorrhagic infarction in this gestational-age group
Samikannu, Balaji [Verfasser]. „Dipeptidyl Peptidase IV inhibition activates CREB and improves islet vascularization through the VEGF-A/VEGFR-2 pathway / Balaji Samikannu“. Gießen : Universitätsbibliothek, 2013. http://d-nb.info/1065065426/34.
Der volle Inhalt der QuelleVeikkola, Tanja. „Dissecting VEGFR-2 and VEGFR-3 function : VEGFR-3 mediates lymphangiogenic signals“. Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/veikkola/.
Der volle Inhalt der QuelleMao, Kaili. „Rôle du Vascular Endothelial Growth Factor-A (VEGF-A) et de son récepteur VEGFR-1 dans le cancer prostatique localisé“. Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0041/document.
Der volle Inhalt der QuelleThis study analysed the expression of angiogenic growth factor, VEGF-A and its receptor, VEGFR-1 in localized prostate cancer. In the first part, we measured the plasma levels of VEGF-A in 100 patients operated with radical prostatectomy for clinically localized prostate cancer. We also measured the tissue expression of VEGF-A using ELISA on the surgical specimen. There were no associations between plasma levels of VEGF-A and the usual prognostic factors of prostate cancer. However, the tissue expression of VEGF-A correlated with Gleason score (P = 0.01). In the second part, we used the same patients group. Patients were prospectively followed with regular PSA determinations.14 patients had a biochemical recurrence. Neither plasma level of VEGF-A (P =0.25) nor tissue expression of VEGF–A (P=0.38) and its receptor VEGFR–1 (p=0,34) were associated with the risk of biochemical recurrence after radical prostatectomy. Finally, we measured the tissue expression of VEGF-A and VEGFR-1 on the surgical specimens of 40 patients who underwent radical prostatectomy for clinically localized prostate cancer. The tissue expression of VEGF-A in patients who experienced progression was significantly higher than in those who remained free of recurrence (P=0.046). However, the expression of VEGFR-1 was similar in both groups. In logistic analysis, the expression of VEGF-A was the most significant predictor of tumor progression. These results suggest that the tissue expression of VEGF-A has a prognostic impact in clinically localized prostate cancer
Mao, Kaili Dinh-Xuan Anh-Tuan. „Rôle du Vascular Endothelial Growth Factor-A (VEGF-A) et de son récepteur VEGFR-1 dans le cancer prostatique localisé“. S. l. : Paris Est, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0494618.pdf.
Der volle Inhalt der QuelleSjöström, Sara. „Risk and prognostic factors for malignant glioma“. Doctoral thesis, Umeå universitet, Onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61905.
Der volle Inhalt der QuelleDias, Fernando José. „Influência de densidades do laser de baixa intensidade sobre o músculo masseter de ratos Wistar“. Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-12082010-150530/.
Der volle Inhalt der QuelleThe laser therapy has been widely used as an alternative treatment in patients with chronic pain related to temporomandibular disorders. This is due to the effects: analgesic, anti inflammatory, muscle relaxant, reducing fatigue during tetanic contractions, increased bite strength and decrease in orofacial pain. Although clinical results are observed, is not well understood its effect on the cellular level. This study aims to analyze the effects of different densities (doses) irradiation of low level laser therapy (LLLI) on cellular level, on the masseter muscle of rats. The animals were randomly assigned to 6 groups (n=10), received 10 laser irradiation (GaAlAs, 780nm, 5mW spot and 0.04 cm²) on the left masseter muscle by varying the energy density (I. 0; II. 0.5; III. 1.0; IV. 2.5; V. 5.0 and VI. 20 J/cm²). After 10 irradiations the masseter muscles were obtained from animals under anesthesia for analysis: 1. Histoenzimologic for nicotinamide adenine dinucleotide (NADH), succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase), 2. Light microscopy (HE), 3. Transmission electron microscopy and 4. Immunohistochemistry for vascular endothelial growth factor (VEGF) and receptor 2 for VEGF (VEGFR-2). The activity of NADH in groups IV, V and VI (30±1,26; 33,47±2,15; 31,67±1,77 - intermediate fiber) increased significantly (p> 0.05) in oxidative metabolism in relation to other groups. The activity of SDH showed a slight increase, only the group V (32,2±1,61 intermediate fiber) increased significantly (p> 0.05), but the pattern of metabolic increase was very similar in both reactions. The ATPase activity showed no differences between groups nor in acid or alkaline. The qualitative analysis showed a pattern of increased expression of VEGF and VEGFR-2 directly proportional to the energy density of laser. Light microscopy showed rounded muscle fibers and peripheral flattened nuclei, which become more rounded with the highest energy densities. Ultrastructurally the irradiation with higher energy densities showed mitochondria of different sizes and shapes and dilated cisterns of sarcoplasmic reticulum between the myofibrils. It is concluded that higher densities of laser was able to increase the oxidative metabolism without altering the contractile capacity, increasing nuclei volume, modify ultrastructure of muscle fibers and the expressions of VEGF and VEGFR-2.
Yin, Lu. „Rational Design and Development of Anti-Angiogenic Protein Agents“. Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/109.
Der volle Inhalt der QuelleSoueid, Jihane. „Contribution des facteurs de croissance vasculaire et de leurs récepteurs au développement du SNC : rôle du VEGFR-3 et de son ligand VEGF-C“. Paris 6, 2010. http://www.theses.fr/2010PA066667.
Der volle Inhalt der QuelleEubank, Tim. „M-CSF and GM-CSF induce human monocytes to express either pro- or anti-angiogenic factors“. The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1069772001.
Der volle Inhalt der QuelleColin, Maité [Verfasser], und Bernd [Akademischer Betreuer] Hohenstein. „Analyse von VEGF, VEGF-Aktivierung und VEGF-Rezeptorexpression bei humanen entzündlichen Nierenerkrankungen / Maité Colin. Betreuer: Bernd Hohenstein“. Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1025963806/34.
Der volle Inhalt der QuelleNilsson, Ingrid. „Hypoxia, PDGF and VEGF in Vascular Development“. Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6894.
Der volle Inhalt der QuelleShi, Shuning. „VEGF-A, VEGF-B and PIGF in mouse oxygen induced retinopathy /“. St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17390.pdf.
Der volle Inhalt der QuelleArantes, Ricardo Vinicius Nunes. „Estudo da angiogênese e da expressão temporal do VEGF e dos seus receptores VEGFR-1/Flt-1 e VEGFR-2/Flk-1 durante o reparo ósseo alveolar normal e com uso terapêutico de um antiinflamatório não esteroidal seletivo para COX-2 em ratos“. Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-12062012-151744/.
Der volle Inhalt der QuelleObjective: To evaluate the effect of Meloxicam on the expression of VEGF and its receptors during the post-extraction alveolar healing in rats. Material and Methods: The extraction of the right upper incisor was made in 180 male Wistar rats, aged 60 days old. The sample was divided in: 1) Control group (n=90) - the rats received intraperitoneal injection of 0.1 ml of 0.9% NaCl daily for 7 days, and 2) experimental group (n=90) - the rats received intraperitoneally 3mg/kg body weight of Meloxicam in 0.9% NaCl solution daily for 7 days. At 3, 7, 10, 14, 21 and 30 days later, the alveolar samples were collected, fixed in 10% formaldehyde in phosphate buffer, radiographed and histologically processed. For RT-PCR, the samples were placed in Trizol and stored at -80° and for Western blotting stored at -80°. Transversal semi-serial histological sections (with 250 um interval) of the whole alveolus were obtained and stained with hematoxylin and eosin. In these sections the volume density of bone tissue (% TO), connetive tissue (% CT), blood clot (Coa%) and blood vessel (% VS) was evaluated by point counting volumetry morphometric method. The obtained data were compared between groups for period by \"t\" test and between periods within each group by ANOVA and Tukey test, with a p<0.05 significance level. Results: a) The radiographic analysis showed changes in the contour of the cortical alveolar bone , reduction in size of the alveolus, and a small increase in radiodensity in their central region ; b) Morphologically the experimental group showed, in all periods, a delay in the repair process as compared to control, displaying greater amount of blood clot with slow replacement by connective tissue and lower cortical alveolar bone resorption and bone formation / remodeling c) In morphometric analysis the %TO in the control group were 0.817, 0.255, 0.368, 0.409 and 0.453 times higher than the experimental group during periods of 3, 7, 10, 14 and 21 days , respectively. The %Coa, the values in the control group were 0,097, 0,611, 1,189 and 1.497 times lower than in the experimental group on days 7, 10, 14 and 21 days respectively. The %VS in the control group showed 0.328 and 0.439 times higher than in the experimental group on days 10 and 14 days respectively. The% CT showed no statistical difference between groups. d) The imumunostaining for VEGF and VEGFR-1 were observed in osteoblasts and osteocytes in the cortical alveolar, and fibroblasts within the alveolus, which was statistically significant only for VEGFR-1, where the immunostaining in the control group was 0,544; 0,325 and 0,325 times higher than the experimental group during periods of 3, 7 and 10 days respectively e) The RT-PCR analysis for VEGF in the control group was 1.274 times higher within 10 days compared to the experimental group. In the expression of mRNA for VEGFR-1, the control group was 1,431; 0,951 and 0,845times higher in periods of 3, 10 and 30 days, respectively, compared to the experimental group and VEGFR-2 was 4.64 and 0.79 times higher in periods of 3 and 7 days, respectively, and f) The protein expression of VEGF in the control group was 0,365; 1,056; 2,187 and 0,350 times higher in periods of 3, 7, 10, 14 and 21 days compared to the experimental group. Conclusions: Based on the present results it was concluded that the use of Meloxicam, antiinflammatory administered daily for 7 days, alters the expression of mRNA and protein of VEGF and its receptors VEGFR, and slows the process of repair and remodeling post extraction alveolar
Jeltsch, Michael. „VEGFR-3 ligands and lymphangiogenesis“. Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/jeltsch/.
Der volle Inhalt der QuelleSattler, Florentine [Verfasser], Sabine [Akademischer Betreuer] Mihm, Jochen [Akademischer Betreuer] Gaedcke und Martin [Akademischer Betreuer] Oppermann. „Zytokinabhängige Expression von EGF und VEGF und ihrer Rezeptoren EGFR und VEGFR-1 im Tumormikromilieu des kolorektalen Karzinoms / Florentine Sattler. Gutachter: Jochen Gaedcke ; Martin Oppermann. Betreuer: Sabine Mihm“. Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1054191530/34.
Der volle Inhalt der QuelleCapp, Clarissa. „Expressão do fator de crescimento endotelial vascular (VEGF) e de seus receptores (VEGFR 1 e 2) em amostras de tecido tireoidiano de pacientes com carcinoma medular de tireóide“. reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/17771.
Der volle Inhalt der QuelleScheidegger, Patrick. „Targeting of human endothelial cells by VEGF and VEGF-like peptide mimetics /“. [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13667.
Der volle Inhalt der QuelleAgreste, Fernanda Rodrigues. „Expressão espaço-temporal do sistema VEGF e do EG-VEGF no timo de cães“. Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08122010-154007/.
Der volle Inhalt der QuelleThe aim this study was therefore to evaluate the expression of growth factors responsible for the vasculogenic process throughout development and initial involution of the canine thymus. For that purpose, thymuses from fetuses (30, 40, 50 and 60 days), juvenile (6 months) and adult (1 year) dogs were collected. The tissues were examined stereologically and subjected to immunohistochemistry, Real Time PCR and western blot for components of the VEGF-system (VEGF-A, VEGF-C, Flt-1, KDR and Flt-4) and endocrine gland-derived (EG)-VEGF. By means of stereology, the total number of blood vessels increased during development and decreased during involution. These changes were statistically significant (p<0.05). All components of the VEGF-system and EG-VEGF were detected in all stages during development and involution. The corresponding proteins were localized in endothelial and epithelial cells of cortical and medullar regions, and EG-VEGF was detected only in epithelial cells of medular region. The VEGF-system and EG-VEGF protein and mRNA expression showed a specific time-dependent profile during development and involution. The VEGF system showed a constant expression during development and a progressive increase during involution, except KDR that showed increased during all development and involution and VEGF-C that showed high expression during involution. The EG-VEGF RNAm expression was increased during development and involution, but protein expression was high in early thymus development and decreased in involution, and remains constant during all period. Our results suggest that VEGF-system and EG-VEGF have similar biological activities in endocrine glands and different roles during thymus development and involution which have to be specified in further studies. Possible functions include a modulatory effect on thymic vasculogenesis and microenvironment, influencing thymocyte proliferation and differentiation, T-cell maturation, cell-cell interaction and thymic hormonal secretion.
Gomes, Luana Pimenta. „Avaliação dos fatores de crescimento endotelial vascular VEGF e de seus principais receptores VEGFR-1 e -2 no processo de cicatrização com influência da radioterapia em ratos da linhagem Wistar“. Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-05112013-125011/.
Der volle Inhalt der QuelleTissue damages of any nature unchain a series of events that will promote regeneration or healing of the injured tissue. This repair is a complex process that involves the interaction of various cells types. These cells are activated by a vast gamma of chemical mediators of the extracellular matrix, microorganisms and chemical and physical alterations in the injury microenvironment and adjacent areas. The participation of vascular endothelial growth factors (VEGF) and their two main receptors (VEGFR-1 and -2) has great importance in the healing process considering neovascularization. After a detailed analysis of the literature about radiotherapy effect in neovascularization and its relation with the expression of VEGF and VEGFR-1 and -2 in the healing, it was observed that there are many questions to be investigated. The objective of this study was to evaluate the immunohistochemical expression of VEGF and VEGFR-1 and -2 and sanguineous vessel density (DVS) after incision and cutaneous repairing in animals under influence of the radiotherapy at three and six months. This study used 60 Wistar rats randomly distributed in six groups: control, preoperative radiotherapy and postoperative radiotherapy, of 3 and 6 month each. The specimens evaluated macro/microscopically were removed after animal\'s sacrifice, in accordance to clinical ethics principles. The immunohistochemistry study of VEGFs were conducted using above-mentioned specific antibodies in manufacturer specified dilutions, while the study of the DVS was performed with the Von Willebrand Factor antibody (VWF) which was used to mark endothelial cells specifically. In both periods studied, surgical wound and radiation damages are similar in most cases. The primarily irradiated cases presented bizarre cellularity, multinucleated giant cells, stromal hyalinization structures, moderate to strong necrosis, overexpression of VEGF receptors in the endothelium and blood vessels in consequence of radiotherapy. These findings are in accordance to the literature, since the strong relationship between VEGFR-2 receptor and its persistence in neovascularization and granulation tissue formation were seen. Our results have shown that VEGF expression is constantly expressed in different times of wound healing and scar formation
Onions, Karen. „The differential modification of glomerular endothelial cell glycocalyx by VEGF-A and VEGF-C“. Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705456.
Der volle Inhalt der QuelleZanella, S. „SYNTHESIS OF PEPTIDOMIMETIC LIGANDS TARGETING CELL-SURFACE RECEPTORS INVOLVED IN TUMOR ANGIOGENESIS“. Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/473075.
Der volle Inhalt der QuelleHedeen, Heather A. „A Kinetic Study of anti-VEGF-A Polyclonal Antibodies and anti-VEGF-A ssDNA Aptamers“. DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/754.
Der volle Inhalt der QuelleCunningham, Crystal. „Expression of Chemokines and VEGFs in HNSCC“. VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1787.
Der volle Inhalt der QuelleSpatola, Agata. „Studio della funzione del VEGF in modelli sperimentali di cellule“. Thesis, Università degli Studi di Catania, 2011. http://hdl.handle.net/10761/234.
Der volle Inhalt der QuelleThe hepatic damage is caused by different factors that operate in several ways. Liver,however,has a good capacity of regeneration, thanks to many molecules which act on neovascularization and/or on epatocytes proliferation.One of these molecules is VEGF so we decided to analise some aspects of its function.We worked on experimental models of HepG2 cells, treated with EtOH and VEGF and, in a second experiment, we treated them with EtOH and HUVEC cells surnatant (Previously, HUVEC were treated with VEGF). Than we used microarray to evaluate the genic espression of several gene families, after HUVEC and HepG2 treatment with, respectively, VEGF and several hepatotoxic substances. Finally, we have studied an anti-apoptotic protein,smp30, as a possible factor which can play an important role in hepatic regeneration.
Klein, Johann [Verfasser]. „Kardiomyozytäre Effekte von VEGF / Johann Klein“. Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064702996/34.
Der volle Inhalt der QuelleOurradi, Khadija. „Unravelling VEGF signalling in the lung“. Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683728.
Der volle Inhalt der QuelleRedondo, Alexandre Rodrigues. „Determinação do sítio de ligação de um peptídeo anti-angiogênico em seus receptores“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11042017-084254/.
Der volle Inhalt der QuelleAngiogenesis is a fundamental and physiological process for vertebrate organisms, being responsible for the formation of new blood vessels, sprouting from the existent ones. However, angiogenesis may occur in pathological conditions, being cause or consequence of diseases. One example is tumor development. To grow beyond a few cubic millimeters, tumors need a suitable supply of oxygen and nutrients, and, therefore, they are dependent of angiogenesis. In fact, anti-angiogenic compounds are already in therapeutic use, targeting not only tumors but other angiogenesis dependent diseases, like retinopathies. In this project, we expand research from our own group to identify and develop anti-angiogenic peptides with translational potential (pre-drugs). Using Phage Display methodology, our group identified and characterized a hexapeptide, that was selected based on its capacity to interact with the receptors for the main initiator factor of angiogenesis, the VEGF (Vascular Endothelial Growth Factor). VEGF receptors (VEGFR) are tyrosine kinase proteins, expressed by endothelial cells and essential for neovascularization initiation and progress. The hexapeptide identified in our lab binds to VEGFRs and inhibit blood vessel formation in vivo when tested in an angiogenesis animal model. In this study, we seek to further understand the interaction of this hexapeptide with its receptor by identifying its binding domain on VEGFR and develop models that will allow the determination of the structural requirements for interaction of this receptor ligand pair. With this knowledge, we can in a near future progress to a rational development of novel peptidemimetic molecules with angiogenic properties similar to this hexapeptide.
Edholm, Dan. „VEGFR-2 in Endothelial Differentiation and Vascular Organization“. Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8579.
Der volle Inhalt der QuelleFüger, Andrea Sylvia [Verfasser]. „Die Bedeutung der Angio-, Lymphangiogenesefaktoren VEGF, VEGF-C und VEGF-D für die Genese und Progression des Zervixkarzinoms und ihr Nutzen für die Diagnostik desselben / Andrea Sylvia Füger“. Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023582880/34.
Der volle Inhalt der QuelleAlmeida, Aroldo dos Santos. „Significado clínico da expressão de VEGF-C e de podoplanina em carcinomas espinocelulares de boca“. Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/25/25136/tde-02042009-103248/.
Der volle Inhalt der QuelleThe expression of vascular endothelial growth factor C (VEGF-C) and podoplanin by malignant cells has been associated with a greater incidence of regional metastasis and/or poor prognosis for patients with oral cancer. The purpose of this study was to evaluate the clinical significance of VEGF-C and podoplanin expression in 42 well-differentiated oral squamous cell carcinomas (OSCC), with and without lymph node involvement, including eight verrucous carcinoma, treated at the Department of the Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Hospital, São Paulo, from 1980 to 2000. Patients were evaluated according the following parameters: gender, age, ethnic group, tobacco and/or alcohol consumption, tumor location, TNM stage, treatment and clinical follow-up (recurrence, occurrence of a second primary tumor and death) and the presence of perineural, muscular, glandular and bone infiltrations or vascular embolizations. In addition, we investigated the histopathological malignancy index and the immunohistochemistry expression of VEGF-C and podoplanin by malignant cells in the invasive front tumor. Chisquare test or Fishers exact test was used to analyze the association of VEGF-C and podoplanin with demographic, clinical and microscopic variables in OSCC patients. The 5 and 10-year survival rates were calculated by Kaplan-Meier method and the comparison of the survival curves were performed using log rank test. Most of OSCC, including verrucous carcinoma, showed a high expression of VEGF-C by malignant cells. The OSCC patients with high expression of VEGF-C showed a tendency, without statistical significance, of local and/or regional recurrence. The overexpression of podoplanin was significantly associated with the male gender (p=0,037), with T1 and T2 stage (p=0,037), with I and II clinical stage (p=0,027) and with the presence of glandular infiltration (p=0,003). The local and regional recurrences were detected more frequently in OSCC with high expression of podoplanin, without statistical significant difference, when compared with those with low expression of the protein. The overall survival rates and cancer specific survival rates for OSCC patients with high VEGF-C expression and the overall survival rate for OSCC patients with podoplanin overexpression were lower than those of OSCC patients with low expression of these proteins. The cervical lymph node involvement was significant prognostic factor (p=0,001) for patients with oral cancer. These results suggest that the overexpression of VEGF-C and podoplanin by malignant cells and regional lymph node involvement are indicative factors of an unfavorable clinical outcome and a poor prognosis for patients with well-differentiated OSCC.
Mallory, Bradford Paul. „The Pulmonary Vasculature Mediates Differential Time-Sensitive Effects on Embryonic Lung Development“. University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116510292.
Der volle Inhalt der QuelleTreweeke, Andrew T. „Expression and function of VEGF and VEGF receptors in malignant B-cells from patients with chronic lymphocytic leukaemia“. Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425473.
Der volle Inhalt der QuelleBiedermann, Katrin. „Generation and Charakterization of VEGF-E-mutants“. Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Departement Chemie und Angewandte Biowissenschaften, 2005. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=173.
Der volle Inhalt der QuelleMüller, Susanne. „VEGF als Surrogatmarker des Therapieverlaufes der pAVK /“. Regensburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254395.
Der volle Inhalt der QuelleSköld, Mattias. „On VEGF and related factors in neurotrauma /“. Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-986-2/.
Der volle Inhalt der QuelleWarren, Simon. „VEGF-hämmare vid behandling av våt makuladegeneration“. Thesis, Umeå universitet, Kemiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80892.
Der volle Inhalt der QuelleBrash, James Thomas. „VEGF isoforms and NRP1 in vascular hyperpermeability“. Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10058912/.
Der volle Inhalt der QuellePawson, Elizabeth J. „VEGF gene therapy in experimental diabetic neuropathy“. Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702481.
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