Thematische Bibliographien / Tumar

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Bücher
  4. Buchteile
  5. Konferenzberichte
  6. Berichte der Organisationen

Auswahl der wissenschaftlichen Literatur zum Thema „Tumar“

Autor: Grafiati
Veröffentlicht am 18. Mai 2024

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Zeitschriftenartikel zum Thema "Tumar"

1

Ким, Д. Ф., und С. Э. Мамедов. „Критерии элитной жилой среды на примере жилого комплекса «Tumar Exclusive»“. ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ 105, Nr. 13 (2024): 18–21. http://dx.doi.org/10.18411/trnio-01-2024-634.

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LEE, CHANG HUN, SANG DON LEE, JUN WOO LEE, JEE YEON KIM, D. O. YOUN PARK, MEE YOUNG SOL und KANG SUEK SUH. „Malignant Osteoclast-like Giant Cell Tumar of the Kidney with Osteosarcomatous Transformation“. Journal of Urology 169, Nr. 1 (Januar 2003): 272–73. http://dx.doi.org/10.1016/s0022-5347(05)64088-8.

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3

Kurlishchuk, Y. V., B. O. Vynnytska-Myronovska, Y. P. Bobak und O. V. Stasyk. „Influence of arginine metabolites on human tumar cell viability upon arginine deprivation in vitro“. Studia Biologica 5, Nr. 2 (2011): 5–16. http://dx.doi.org/10.30970/sbi.0502.148.

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4

Baibolov, A. U. „Artistic Reality in the Dramas of Sultan Raev“. Iasaýı ýnıversıtetіnіń habarshysy 130, Nr. 4 (15.12.2023): 116–25. http://dx.doi.org/10.47526/2023-4/2664-0686.10.

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The article analyzes the plays of a major representative of Kyrgyz literature, playwright, public figure Sultan Raev from the point of view of artistic reality. In origin, each piece of art is an entire structure with a fully completed head and legs. There should also be a succession network. Considering that the largest type of epic genre is drama, which is in historical and evolutionary development, the most prone to transformation and modification in accordance with the requirements of time, time, epoch, the drama of the countries of Central Asia: Kazakhstan, Uzbekistan, Tajikistan, Turkmenistan and Kyrgyzstan with new authors, new themes is filled and promotes common values not only of the Turkic people, but also of a human being, thereby the author raises topical issues. Sultan Rayev’s drama “The Long Way to Mecca” touched upon such complex issues as human purification, self-knowledge, finding your way in life, responding to what you have done, liberation from sin, and the magical connection between man and God. In the dramas “Tears of the Queen” and “The Crown», where the symbols of the absurd and the genre prevail, the historical theme is touched upon. Three dramatic works by the author were taken as research materials: “Tears of the Queen”, “The Crown” and “The Long Way to Mecca”. Hermeneutical, comparative typological, and semiotic methods were used in the analysis of these works. In the course of the study, we identified similarities and differences in comparing the author's plays, and also identified the semiotic aspect of the drama based on the analysis of characteristic features: takara, sand, black stone, crown, tumar.
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Beşirli, Prof Dr Hayati. „YABANCI SEYYAHLARIN GÖZÜNDEN FARKLI YÜZYILLARDA TÜRK YEMEK KÜLTÜRÜ“. Türklük Bilimi Araştırmaları, TÜBAR GÜZ 2016 (01.12.2016): 11. http://dx.doi.org/10.17133/tubar.270425.

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ÇINAR, Prof Dr Bekir. „MEVLÂNÂ’NIN MESNEVÎSİNDEKİ “NAHİVCİ İLE GEMİCİ” HİKÂYESİNİN MANTIKU’T-TAYR’DA İŞLENİŞİ“. Türklük Bilimi Araştırmaları, TÜBAR GÜZ 2016 (01.12.2016): 33. http://dx.doi.org/10.17133/tubar.270428.

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DALYAN, Dr Ayşe. „AHMEDÎ’NİN BİR MEDHİYESİNDE OSMANLI SOSYAL HAYATINA DAİR İZLER: GAZİ TİPİ-KUL TİPİ“. Türklük Bilimi Araştırmaları, TÜBAR GÜZ 2016 (01.12.2016): 45. http://dx.doi.org/10.17133/tubar.270429.

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ERDOĞAN, Yrd Doç Dr Songül. „NİĞDE YÖRESİ AĞZINDAN DERLEME SÖZLÜĞÜ’NE KATKILAR- 1“. Türklük Bilimi Araştırmaları, TÜBAR GÜZ 2016 (01.12.2016): 69. http://dx.doi.org/10.17133/tubar.270431.

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KALFA, Doç Dr Mahir. „BULMAK VE BULUNMAK FİİLLERİNİN ANLAM VE KULLANIM ÖZELLİKLERİ“. Türklük Bilimi Araştırmaları, TÜBAR GÜZ 2016 (01.12.2016): 83. http://dx.doi.org/10.17133/tubar.270432.

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KARACA, Prof Dr Nesrin. „HAYATIN “EŞİK” DURUMU BAĞLAMINDA ve SİVAS EVLENME GELENEĞİNDE “GELİN” KÜLTÜRÜ“. Türklük Bilimi Araştırmaları, TÜBAR GÜZ 2016 (01.12.2016): 105. http://dx.doi.org/10.17133/tubar.270436.

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Dissertationen zum Thema "Tumar"

1

Tumar, Iyad [Verfasser]. „Resource Management of Disruption Tolerant Networks / Iyad Tumar“. Aachen : Shaker, 2011. http://d-nb.info/1081884959/34.

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Das, Sanjib Kumar. „Characterization of Tumar infiltrating lymphocytes in marine sarcoma and their role in curbing malignancy“. Thesis, University of North Bengal, 1997. http://hdl.handle.net/123456789/1006.

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Svanberg, Frida, und Timothy Shen. „EN FÖRÄNDRAD IDENTITET : Sexualitetens påverkan i samband med bröstcancer. En litteraturöversikt“. Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-10471.

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Bakgrund: I Sverige drabbas 8000 kvinnor av bröstcancer varje år. Dessa kvinnor utsätts för både kroppsliga och emotionella biverkningar och förändringar. Syfte: Syftet med denna litteraturöversikt är att belysa hur kvinnor som drabbas av bröstcancer upplever att deras sexualitet påverkas av sjukdom och behandling. Metod: Metoden var en litteraturstudie. Resultat: Ett huvudtema framkom en förändrad identitet; och fem subteman: kroppsliga förändringar, känna sig okvinnlig, relationens betydelse, kommunikationens betydelse för att komma vidare och sjukvårdens betydelse. Slutsats: Resultatet visade att kvinnorna upplevde att de förlorat sin sexuella identitet och sin kvinnlighet. Förlusten gjorde att de inte kunde identifiera sig med den kvinna som de tidigare varit. De upplevde flera fysiska förändringar som ledde till minskad sexuell aktivitet. Men trots den minskade sexuella aktiviteten upplevde många av kvinnorna en ökad närhet till sin partner och stödet från en partner ansågs viktigt. Många kvinnor saknade dock stöd och information från sjukvården angående sexuella problem. De upplevde att vårdpersonalen tyckte det var genant eller oviktigt att tala om kvinnornas sexualitet. Då sjuksköterskans primära mål är att främja hälsa och välbefinnande bör sjuksköterskan beakta kvinnornas sexualitet eftersom sexualiteten är en viktig dimension för upplevelsen av hälsa.
Background: In Sweden 8000 women are afflicted by breast cancer every year. These women are subject to both physical and mental side effects and alternations. Aim: The objective of this literature review is to highlight how women in the case of breast cancer experience that their sexuality is affected by the disease and treatment. Method: The method is a review of the related literature. Results: One major theme emerges: a changed identity, and five minor themes: physiological changes, feeling unfeminine, the significance of relationship, the significance of communication in order to move on, and the significance of medical care. Conclusion: It turns out that these women experienced a loss of their sexual identity and their femininity. The deprival resulted in an inability to identify themselves with the women they once were. They also experienced physiological changes, e.g. dryness of the vaginal mucous membrane, pain from the removed breast, and less sexual arousal which impeded and reduced the sexual activity of the women. But despite reduced sexual activity, many of these women experienced acquiring a greater proximity to their partner, and that the support from a partner was regarded as important. Many of the women, though, lacked support and information from the medical institutions concerning sexual problems. They experienced that the medical staff thought that conversing upon the women’s sexuality was something embarrassing or of no importance. Since the primary objective of the nurse is to promote health and well-being, the nurse should take heed to and attend to the sexuality of the women, considering that sexuality is an important dimension in regard to experiencing health.
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Butler, Savannah E. „TUMOR-INTRINSIC INFLAMMATORY PATHWAYS ASSOCIATED WITH TUMOR DORMANCY AND RECURRENCE“. VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4753.

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The successful treatment of breast cancer is limited due to a fraction of tumor cells escaping drug-treatment by entering a dormant state, only to relapse years or decades later at distant sites. Host-driven chronic inflammatory cells such as M2 macrophages play an important role in tumorigenesis, but the role of tumor-intrinsic inflammatory signaling involved in tumor dormancy and recurrence is unknown. We sought to determine the role of tumor-intrinsic inflammatory pathways in mouse mammary carcinoma cells (MMC) treated with Adriamycin (ADR), a clinically relevant chemotherapeutic drug. We found that ADR-induced dormant tumor cells autonomously produced pro-inflammatory cytokines, in vitro. MMC treated with Chloroquine (CQ) prior to ADR treatment displayed a delay in relapse, or prolonging of dormancy, when compared to ADR-treated MMC. Additional gene array data showed predicated activation of NF-κB p65 in ADR-treated dormant MMC that eventually relapsed. These data suggest that the anti-inflammatory function of CQ led to prolonged dormancy. To test this, we investigated the role of inflammatory signaling pathways directly by shRNA-mediated knockdown and CRISPR-Cas9-mediated knockout of NF-κB p65 in MMC. We found that knockdown of NF-κB p65 resulted in fewer dormant cells after ADR treatment and reduced rate of relapse, in vitro. NF-κB p65 was also found to reduce the immunomodulatory effects of ADR, with shNF-κB p65 showing increased upregulation of neu upon ADR treatment. Additionally, we found NF-κB p65 to be associated with a higher infiltration of CD8+ T cells and anti-tumor T cell responses. Our findings suggest a dual role of tumor-intrinsic NF-κB p65 pathway, allowing for escape from drug treatment through dormancy which leads to relapse, but also for proper lymphocyte infiltration and subsequent anti-tumor activity.
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Casiraghi, Nicola. „Quantitative analyses to study tumor clones dynamics and tumor heterogeneity“. Doctoral thesis, Università degli studi di Trento, 2017. https://hdl.handle.net/11572/368498.

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Prostate cancer is a highly heterogeneous disease and its manifestations can vary from indolent localized tumor to widespread metastases. This heterogeneity is also observed at the molecular level both inter- and intra-patient. Intra-patient heterogeneity in the clinical setting of men with castration resistant prostate cancer (CRPC) might be informative in terms of treatment decision. Here I present analytical work on two approaches relevant to the characterization of intra-patient heterogeneity and applied to unpublished CRPC patients sequencing data. The first is based on the genome wide interrogation of multiple metastatic and primary tissue biopsies from single patients. I present genomic analyses to decipher the content of multiple tumor biopsies from CRPC patients and provide comparisons to highlight similarities and differences and to identify alternative patterns of aberrations. The second approach, alternative to tissue biopsies that might under-represent the genomic landscape of the patient’s disease, relies on liquid biopsies, a minimally invasive test that is also amenable to serial sampling. Liquid biopsies contain circulating cell free DNA (cfDNA) released from widespread tumor cells, potentially uncovering the full tumor landscape. By using next generation sequencing on cfDNA obtained from plasma, I developed strategies aimed at systematically tracking the reiterative process of genetic diversification leading to disease evolution and to detect genomic aberrations. I specifically focused on an ad hoc computational procedure (ABEMUS) to detect somatic point mutations that could emerge under treatment pressure and as drug resistance mechanism. The work I present is relevant to the context of precision oncology that exploits detailed patient-specific molecular information to diagnose and follow cancer progression with the ultimate goal of promptly guiding treatment decisions to improve clinical outcome with transdisciplinary strategies. The analytical work I developed can be applied to the study of any tumor type.
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Casiraghi, Nicola. „Quantitative analyses to study tumor clones dynamics and tumor heterogeneity“. Doctoral thesis, University of Trento, 2017. http://eprints-phd.biblio.unitn.it/2626/2/Disclaimer_Casiraghi.pdf.

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Prostate cancer is a highly heterogeneous disease and its manifestations can vary from indolent localized tumor to widespread metastases. This heterogeneity is also observed at the molecular level both inter- and intra-patient. Intra-patient heterogeneity in the clinical setting of men with castration resistant prostate cancer (CRPC) might be informative in terms of treatment decision. Here I present analytical work on two approaches relevant to the characterization of intra-patient heterogeneity and applied to unpublished CRPC patients sequencing data. The first is based on the genome wide interrogation of multiple metastatic and primary tissue biopsies from single patients. I present genomic analyses to decipher the content of multiple tumor biopsies from CRPC patients and provide comparisons to highlight similarities and differences and to identify alternative patterns of aberrations. The second approach, alternative to tissue biopsies that might under-represent the genomic landscape of the patient’s disease, relies on liquid biopsies, a minimally invasive test that is also amenable to serial sampling. Liquid biopsies contain circulating cell free DNA (cfDNA) released from widespread tumor cells, potentially uncovering the full tumor landscape. By using next generation sequencing on cfDNA obtained from plasma, I developed strategies aimed at systematically tracking the reiterative process of genetic diversification leading to disease evolution and to detect genomic aberrations. I specifically focused on an ad hoc computational procedure (ABEMUS) to detect somatic point mutations that could emerge under treatment pressure and as drug resistance mechanism. The work I present is relevant to the context of precision oncology that exploits detailed patient-specific molecular information to diagnose and follow cancer progression with the ultimate goal of promptly guiding treatment decisions to improve clinical outcome with transdisciplinary strategies. The analytical work I developed can be applied to the study of any tumor type.
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Diego, Ángeles Pedro, Ximena Vega und José Palacios. „Tumor mucoso apendicular“. Asociación Colombiana de Cirugía, 2016. http://hdl.handle.net/10757/615473.

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Los tumores mucosos apendiculares tienen baja incidencia y comúnmente se diagnostican en el estudio anatomo-patólogico después de la apendicectomía. Se reporta el caso de una mujer de 41 años de edad, con un cuadro clínico de ocho meses de evolución, caracterizado por dolor abdominal de tipo opresivo, difuso y de gran intensidad en el hemiabdomen inferior, acompañado de náuseas. Después de cinco meses de iniciado este cuadro clínico, se evidenció una masa en la fosa iliaca derecha; el dolor se agudizó e intensificó, y las náuseas continuaron, por lo cual fue remitida al hospital. En los exámenes practicados se observó una masa quística compleja abdomino-pélvica de origen indeterminado, y la tomografía computadorizada de abdomen fue sugestiva de mucocele apendicular. Con estos hallazgos, se optó por el tratamiento quirúrgico por laparotomía, consistente en hemicolectomía derecha, con resección parcial de íleon, epiplectomía, histerectomía y salpigooforectomía bilateral.
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Petty, Aaron. „Novel MIG-7 expression increases tumor cell invasion and tumor progression“. Online access for everyone, 2008. http://www.dissertations.wsu.edu/Thesis/Spring2008/a_petty_040908.pdf.

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Anderson, Jeff. „Genetic Analysis Of Specialized Tumor Associated Macrophages And Tumor Associated Fibroblast“. The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1228083946.

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Liu, Jian. „POLYMER MODIFICATION OF FULLERENE FOR PHOTODYNAMIC TUMOR THERAPY AND TUMOR IMAGING“. 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120886.

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Bücher zum Thema "Tumar"

1

Beldiceanu, Nicoara. XIV. Yüzyıldan XVI. Yüzyıla Osmanh Devleti̓nde Tumar. Ankara: Teori, 1985.

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Noel, Tuazon, Hrsg. Tumor. Los Angeles, Calif: Archaia Entertainment, 2010.

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Tūmar. Almaty: Arys, 2006.

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Tumak. Karācī: ʻIlm o Adab Pablishar ainḍ Buk Selar, 2019.

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Kumāra, Siṃha Aśoka. Tuma pāim̐: Tuma pain. Bhubaneswar: Timepass, 2010.

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Bhutia, Sujit Kumar, Hrsg. Autophagy in tumor and tumor microenvironment. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6930-2.

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C, Ghosh Bimal, und Ghosh Luna, Hrsg. Tumor markers and tumor-associated antigens. New York: McGraw-Hill, 1987.

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Jībodha, Mukeśa. Tuma. Moka, Mauritius: Mahātmā Gāndhī Saṃsthāna, 1995.

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Sirenevyĭ tuman. Moskva: ĖKSMO, 2004.

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Birbrair, Alexander, Hrsg. Tumor Microenvironment. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62658-7.

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Buchteile zum Thema "Tumar"

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Hegazi, Tarek M., und Jim S. Wu. „Tumor/Tumor-Like Lesions“. In Musculoskeletal MRI, 203–30. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26777-3_7.

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Bährle-Rapp, Marina. „Tumor“. In Springer Lexikon Kosmetik und Körperpflege, 569. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_10811.

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George, Bernard, und Claude Laurian. „Tumor“. In The Vertebral Artery, 58–76. Vienna: Springer Vienna, 1987. http://dx.doi.org/10.1007/978-3-7091-6967-4_6.

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Peterson, Hamlet A. „Tumor“. In Physeal Injury Other Than Fracture, 115–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22563-5_4.

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Arampatzis, Adamantios, Lida Mademli, Thomas Reilly, Mike I. Lambert, Laurent Bosquet, Jean-Paul Richalet, Thierry Busso et al. „Tumor“. In Encyclopedia of Exercise Medicine in Health and Disease, 883. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_4565.

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Gooch, Jan W. „Tumor“. In Encyclopedic Dictionary of Polymers, 930. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_15033.

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Zuazo-Gaztelu, Iratxe, und Oriol Casanovas. „Mechanisms of Tumor Angiogenesis“. In Tumor Angiogenesis, 3–31. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-33673-2_1.

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Ribatti, Domenico. „Anti-angiogenic Cancer Therapy: Development of Resistance“. In Tumor Angiogenesis, 313–23. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-33673-2_11.

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Pircher, Andreas, Normann Steiner und Eberhard Gunsilius. „Cytotoxics and Anti-angiogenics: Metronomic Therapies“. In Tumor Angiogenesis, 327–47. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-33673-2_12.

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Schanne, Daniel H., Anca-L. Grosu und Dan G. Duda. „Anti-angiogenics and Radiation Therapy“. In Tumor Angiogenesis, 349–58. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-33673-2_13.

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Konferenzberichte zum Thema "Tumar"

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He, Zhi Zhu, und Jing Liu. „Growth-Induced Stress Inside Solid Tumor Using Thermoelasticity Model“. In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65745.

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The tumor growth strongly depends upon the availability of nutrients. Many experimental evidences recently indicated that stress play important role in tumor invasion. The growth-induced stress is from pressure imposed on tumor by surrounding tissues due to tumor expansion invasion. This paper introduces a model to characterize growth-induced stress in solid tumor by analogy with thermoelasticity theory. The model is composed of a nutrients diffusion equation and a stress evolution equation. The solid spheroid tumor stress distribution induced by tumor spatial non-uniformity growth is studied. Moreover, the mechanical interactions between the solid tumor and the surrounding host tissue are discussed detailed.
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He, Zhi Zhu, und Jing Liu. „Investigation of Tumor Growth Based on Phase Field Model“. In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65744.

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This paper presents and investigates the tumor growth based on a phase model. The tumor core is necrotic and inhibitor chemical species are considered. The interface of tumor and health tissue is tracked using a phase field equation. The reformulation of a classical model, accounting for cell-proliferation, apoptosis, cell-to-cell and cell-to-matrix adhesion, is derived. The advantages of the finite difference methodology employed are generality and relative simplicity implication. We present simulations of the nonlinear evolution of growing tumors morphology and discuss the effects of tumor microenvironment. Mechanisms reflecting the tumor growth and development behavior was preliminarily interpreted. Recently numerous mathematical have been developed to investigate the growth dynamics of tumor [1–8]. One of most significant model developed by Wise [8] is based on Cahn-Hilliard equation, which is conservation phase field method. Allen-Chan nonconservation phase field has been developed to track the moving interface for multiphase simulation by Sun [9]. Allen-Chan equation is second order, while Cahn-Hilliard equation is fourth order in space. Thus, we introduce the Allen-Chan phase method [9–10] to simulate the tumor growth, which is very simple for numerical simulation The computation domain is illustrated in Fig. 1, where ΩH denotes host tissue, the tumor domains is comprised of viable tumor cell ΩV and dead tumor cell ΩD. The numerical results are presented at Fig. (2–4). One can find that the growth of tumor strongly depend on the nutrients and nonlinear unstable growth may lead to finger shaped pattern, which is in agreement with recent experimental observations [7] of in vivo tumor. In summary, a phase method has been developed to study diffusion and consumption of the nutrients and tumor cell proliferation, necrosis and migration, which discloses the evolution of complex shape of tumor.
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Camargo, Luana Cristina, Joao Paulo Figueiro Longo, Karen Letycia Rodrigues de Paiva, Marina Mesquita Simões, Thais Bergmann und Victor Carlos Mello da Silva. „Immunotherapy vaccines for triple-negative breast cancer and its influence on the tumor microenvironment“. In Brazilian Breast Cancer Symposium 2023. Mastology, 2023. http://dx.doi.org/10.29289/259453942023v33s1024.

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Objective: Cancer is still a complex and debilitating disease even though advances in treatment have occurred. Triplenegative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis and occurs more frequently in young women. Due to its metastatic features and unique tumor microenvironment, TNBC treatment is limited. In this study, we evaluated how three chemotherapy drugs could be used to produce vaccines with cells under immunogenic cell death. Methodology: For that, 4T1-luc2 cells were treated with cisplatin (100 μM), mitoxantrone (MTX) (15 μM), and doxorubicin (DOX) (50 μM) for 24 h. Then, the treated cells were injected subcutaneously in tumor-bearing Balb/c female mice, after the tumor challenge. The treatment occurred three times, once a week. During and after the treatment, primary tumor and metastatic progression were followed using the chemiluminescence technique. After 5 weeks of the tumor challenge, mice were euthanized and organs (liver, tumor, lungs, and spleen) were collected for analysis. Additionally, the spleens were processed for flow cytometry for regulatory T lymphocyte and myeloid-derived suppressor cells analysis. Results: Cisplatin and MTX vaccines slowed the primary and metastatic tumor growth as well as the decreased tumor, liver, and spleen weight, while the DOX vaccine slowed the metastatic tumor progression in the lungs but did not alter tumor and other organs’ weight. Moreover, cisplatin and MTX vaccine increased the ratio of lymphocytes in the spleen but not the DOX vaccine. All comparison was done regarding the tumor-bearing mice treated with PBS. Conclusion: Taken together, both MTX and cisplatin vaccines treated primary and secondary tumors probably by the increase of lymphocyte recruitment, and the cisplatin vaccine also has an influence on the tumor microenvironment. Finally, the therapeutical vaccine might be an interesting approach as a treatment for TNBC due to its positive effect on metastasis and tumor microenvironment, especially with cisplatin.
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Deng, Zhong-Shan, und Jing Liu. „The Effects of Large Blood Vessels on Three-Dimensional Tissue Temperature Distributions During Electromagnetic Induced Nano-Hyperthermia: Numerical Simulation“. In 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2008. http://dx.doi.org/10.1115/micronano2008-70269.

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As is well known, the blood flowing through large blood vessels acts as a heat sink and plays an important role in affecting temperature profiles of heated tissues [1]. In hyperthermia, heating is usually limited to the tumor and a small margin of the surrounding tissue. Since the temperatures in the rest of the body remain normal, the blood that supplies the tumor will be relatively cold. Consequently, the blood flow inside a large vessel will represent a sink which cools the nearby heated tissues and then limits heating lesion during tumor hyperthermia. Under this adverse condition, a part of vital tumor cells may remain in the thermally lethal area and lead to recurrence of tumors after hyperthermia treatment. More specifically, tumor cell survival in the vicinity of large blood vessels is often correlated with tumor recurrence after thermal therapy. Therefore, it is difficult to implement an effective hyperthermia treatment when a tumor is contiguous to a large blood vessel or such vessel transits the tumor. How to totally destroy tumor cells in the vicinity of large blood vessels has been a major challenge in hyperthermia [2].
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Zhang, Aili, Xipeng Mi und Lisa X. Xu. „Study of Thermally Targeted Nano-Particle Drug Delivery for Tumor Therapy“. In ASME 2008 First International Conference on Micro/Nanoscale Heat Transfer. ASMEDC, 2008. http://dx.doi.org/10.1115/mnht2008-52383.

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The efficacy of cancer chemotherapeutics could be greatly enhanced by thermally targeted nanoparticle liposome drug delivery system. The tumor microvasculature response to hyperthermia and its permeability to the nano-liposomes were studied using the 4T1 mouse model and confocal fluorescence microscopy. Based on the experimental results, a new theoretical model was developed to describe the distributions of both the liposomal and free drug released as liposomes broke in tumor for treatment evaluation. In this model, the tumor was divided into two regions: peripheral and central. The drug effect on the tumor cell apoptosis and necrosis was considered. Upon the experimental validation, the model was used to simulate drug distribution in the tumor under either the hyperthermic or the alternate freezing and heating condition. Results showed that hyperthermia alone only enhanced drug accumulation in the tumor periphery and therefore more serious tumor damage induced in the region. But the tumor cells in the central region were hardly damaged due to the lack of drug diffusion. The alternate freezing and heating was proposed to aid the nanoliposomal drug delivery, and better results were found.
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Liu, Ping, Xiaomin Ren und Lisa X. Xu. „Alternate Cooling and Heating Thermal Physical Treatment: An Effective Strategy Against MDSCs in 4T1 Mouse Mammary Carcinoma“. In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80229.

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An alternate thermal physical treatment was developed to destroy tumor tissue using liquid nitrogen cooling and RF heating treatment in our pervious study. Our pervious reports had shown that anti-tumor immunity was induced by the alternate treatment. Myeloid derived suppressor cells (MDSCs) are a subset of heterogeneous, bone marrow derived hematopoietic cells that accumulate in the spleen, bone marrow, blood and tumor sites of tumor-bearing mice and cancer patients. MDSCs are one of the key suppressor cells that regulate anti-tumor immune responses in tumor-bearing hosts. MDSCs have been shown to inhibit the function of various types of cells mediating anti-tumor immunity, such as T cells, B cells, NK cells and dendritic cells. MDSCs are recruited specifically to the tumors and contribute indirectly to angiogenesis, growth and metastasis. MDSCs also exert resistance to cancer therapies, such as anti-VEGF strategies and cancer immunotherapy. Given the role of MDSCs in tumor invasion and metastasis and anti-tumor immune responses, therapeutics targeting MDSCs might offer a new strategy for cancer treatment. In this study, the therapeutic effect and MDSCs changes after the alternate cooling and heating treatment was studied using the 4T1 murine mammary carcinoma, a common animal model of human metastatic breast cancer. Due to its highly invasive and poorly immunogenic characters, the 4T1 tumor could cause death even after the primary tumor was surgically removed. The treatment was carried out when micro-metastases were well established. Comparisons were made with the results from the surgery and hyperthermia groups, respectively. The results showed that MDSCs in blood increased rapidly with time after tumor inoculation, and in 66 days, all the mice died in the control group. The statistical results indicated a significant increase in circulating MDSC numbers at different tumor growth stages. In the surgical resection group, MDSCs in blood did not decrease, but increased rapidly to a level much higher that of the control group in 39 day after tumor inoculation. In the hyperthermia group, MDSCs in blood increased rapidly with time after tumor inoculation, and in 39 day, MDSCs was up to 3 times higher than that of the control group. Mice died in 45 day after initial tumor inoculation. But in the alternate treatment group, the number of MDSCs decreased rapidly and recovered to the normal healthy level in 11 days after the treatment. No metastatic tumor could be observed in these mice, and they were in good physiological conditions as observed in the following 3 month. In conclusion, the alternate treatment was found extremely effective against MDSCs in the very aggressive and highly metastatic mouse mammary carcinoma. The good prognosis was expected in relation to the significant decrease in MDSCs and thus the relief of the immune suppression, induced by the alternate cooling and heating treatment. It could be further developed as a novel therapeutic method against metastatic tumor. On the other hand, combining the alternate treatment with other strategies, such as anti-VEGF and cancer immunotherapy, the best therapeutic effect would be achieved through synergy.
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Agrawal, Sonam, und Pushpa Dahiya. „A rare case of ovarian and endometrial adenocarcinoma metastasized from carcinoma of jejunum“. In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685358.

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Introduction: Krukenberg tumor of ovary is a rare clinical entity and accounts for 1-2% of all ovarian tumor. Stomach is most common primary site but other organs can also serve as a primary site. Accurate diagnosis of krukenberg tumor requires thorough endoscopic and histopathological examination to exclude primary tumor. Case Report: 32 years old female presented with AUB for 2 months and history of jejunum carcinoma which was an incidental finding on biopsy after a surgery for intestinal obstruction. Endometrial biopsy showed endometrial carcinoma of mucin secreting signet ring type. CECT showed bilateral adnexal masses. Staging laparotomy was planned but due to dense adhesion and bladder and bowel infiltration optimal debulking could not be done and tumor was removed as much as possible. Patient was reffered for chemotherapy. Conclusion: Krukenberg tumor is uncommon metastatic signet ring cell adenocarcinoma of ovary with transcoelomic spread. It is essential to rule out other ovarian malignancy to avoid the misdiagnosis and management of krukenberg tumor.
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Pyrz, Matthew, und James Baish. „Effect of Tumor Heterogeneity on Interstitial Pressure and Fluid Flow“. In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14089.

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Delivery of drugs to solid tumors is often impeded by the elevation of the interstitial fluid pressure at the tumor core and the loss of plasma from the tumor to the surrounding normal tissue. Interstitial pressure in tumors is abnormally high because tumor blood vessels are highly permeable relative to their normal counterparts and tumors lack functional lymphatic vessels that can absorb the excess fluid loss [1]. As a result, there is a net outward flow of plasma-like fluid through the interstitial spaces of the tumor toward the exterior of the tumor where functional lymphatics may be found (Fig. 1).
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Voigt, Elizabeth, Cara F. Buchanan, M. Nichole Rylander und Pavlos Vlachos. „Blood Flow Characterization in a Perfused Collagen Vessel Bioreactor Using X-Ray Micro-PIV“. In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80700.

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Newly developed cancer therapies must pass through a series of increasingly complex testing regimens before obtaining FDA approval as valid treatments. The costs of these tests increase rapidly as the physiological accuracy of the platform increases, from initial proof-of-concept in static tissue cultures, to treatment of animal models, and ultimately to human clinical trials. Three-dimensional engineered blood-perfused tumor models are becoming increasingly important as intermediate platforms for the study and treatment of cancer, as they are superior to static two-dimensional cultures in their reproduction of relevant physiological conditions and are inexpensive in comparison to animal models. Because of this, the design of well-characterized adaptable in vitro vascular tumor models has become a central objective of the emerging field of tumor engineering. Characterization of the flow within three-dimensional tumor models is critical for quantifying fluid shear stress and determining its role in pivotal tumor development processes such as tumor cell angiogenesis and metastasis. Ultimately, this knowledge will provide new avenues for therapeutic modulation of the tumor microenvironment.
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Premasiri, Amaranath, Gemunu Happawana und Arye Rosen. „Analytical Porous Media Model of Light Penetration in Photodynamic Therapy“. In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38019.

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Photodynamic therapy (PDT) is currently being developed as a new therapeutic modality with minimal side effects in the treatment of many different types of cancers [1]. PDT requires three essential components, which includes a photosensitizing agent, activation light, and molecular oxygen [2, 3]. Light is one of the governing components for PDT, and the only component that can be controlled externally [4]. The understanding of light penetration in a tumor is critical for an efficient PDT protocol. A well-designed PDT protocol provides minimal microvascular damage and efficient killing of malignant tumor cells [5–7]. The depth of light penetration in a tumor depends on the microvascular nature of the tumor, amount of solid and liquid contents present, and the wavelength of the light source. The first two factors depend on the nature of the tumor tissue and therefore the optimal light dose is not standard for all tumors. Furthermore the liquid content of a tumor changes with the tumor temperature due to vasodilatation, and this in turn affects the depth of light penetration.
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Berichte der Organisationen zum Thema "Tumar"

1

Jorge Sálamo, Dante Noah, und Julio Plata-Bello. Expresión de TRPM8 en el glioblastoma. Fundación Avanza, Mai 2023. http://dx.doi.org/10.60096/fundacionavanza/1482022.

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El glioblastoma es el tumor cerebral primario maligno más común y agresivo. EL TRPM8 es un canal que podría tener relación con este tumor. También se estudió la relación entre el TRPM8, el AR y el glioblastoma
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2

Pacheco-Ojeda, Luis, Carolina Sáenz-Gómez, Stalin Cañizares-Quisiguiña, Tatiana Borja-Herrera, Juan Carlos Vallejo-Garzón und Sergio Poveda. Function Sparing Conservative Approach of a Low-Grade Chondrosarcoma of the Larynx: Case Report and Literature Review. Science Repository, März 2024. http://dx.doi.org/10.31487/j.scr.2024.01.04.

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Background: Laryngeal cancer is relatively uncommon in Ecuador. Usually epithelial in origin, the most frequent histological type is squamous cell carcinoma. The most common mesenchymal tumor is chondrosarcoma. Most laryngeal chondrosarcomas are treated with total laryngectomy, but a conservative function sparing resection is recommended in low-grade limited tumors. Case Report: In a 68-year-old female nonsmoker patient, a small tumor was found in the posterior left aspect of the cricoid cartilage in a computed tomography (CT) performed immediately after an unexpected difficulty to pass the endotracheal tube for a thoracoscopic biopsy of 4 cm tumor of the left lung, in another hospital. The patient underwent, then, an initial tracheostomy, a total thyroidectomy for a goiter and a biopsy of the tumor of the cricoid cartilage whose pathological study was inconclusive. One month later, a low-grade neuroendocrine pulmonary tumor was completed resected. Two years later, a CT scan showed the cricoid lesion with the same characteristics. At endoscopic video laryngoscopy, two subglottic masses that narrowed the airway in approximately 60% of the normal caliber, were observed located at the posterior and left walls. An intraluminal resection was performed through a transcricoid anterior approach. The pathological diagnosis was a low-grade chondrosarcoma. Tracheal decannulation was performed one month later. At an endoscopic video laryngoscopy performed six months post-operatively, the tracheal caliber and mucosa were normal. The patient remained with normal voice and breathing. Conclusion: We report the second case of chondrosarcoma of the larynx in our country, treated by a conservative approach.
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3

Jordan, Jacob. On-treatment changes in pediatric parameningeal rhabdomyosarcoma treated with upfront proton therapy. University of Tennessee Health Science Center, Januar 2022. http://dx.doi.org/10.21007/com.lsp.2022.0008.

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The project is focused on the effects of longitudinal changes in patient and tumor anatomy on the delivered treatment plan during proton radiotherapy for the treatment of pediatric Para meningeal rhabdomyosarcoma. The study will investigate the effects of change on dose delivered to organs-at-risk near the tumor. This effort will extend the analysis of changes to the organs-at-risk to all the cases in the study and add an additional case meeting the study criteria.
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4

Liu, Hanli. Non-Invasive Monitoring of Breast Tumor Oxygenation: A Key to Tumor Therapy Planning and Tumor Prognosis. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada399998.

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5

Liu, Hanli. Non-Invasive Monitoring of Breast Tumor Oxygenation: A Key to Tumor Therapy Planning and Tumor Prognosis. Fort Belvoir, VA: Defense Technical Information Center, September 2002. http://dx.doi.org/10.21236/ada413009.

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6

Albertson, B., und S. Binney. Pituitary tumor evaluation. Office of Scientific and Technical Information (OSTI), November 1995. http://dx.doi.org/10.2172/421339.

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Stein, Stanley, und Michael J. Leibowitz. Autologous Tumor Vaccination. Fort Belvoir, VA: Defense Technical Information Center, Juli 2002. http://dx.doi.org/10.21236/ada407668.

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8

Arévalo-Sáenz, Alejandra, Borja Ferrández Pujante und Fernando J. Rascón-Ramírez. Peritumoral Edema in Resected Meningiomas: Study of Factors Associated with the Variability of Postoperative Duration. Science Repository, März 2024. http://dx.doi.org/10.31487/j.scr.2024.01.05.

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Background: It is well known that edema can persist after meningioma resection, and sometimes it is not resolved after this time. This study aimed to establish the relationship between a series of variables associated with meningioma or surgery, and the duration of postoperative edema. Methods: We conducted a retrospective study of 77 meningiomas resected at our institution between January 2016 and January 2018 with a maximum follow-up period of up to three years. The independent variables collected were demographics, tumor location, relationship with the sinuses (invasion/contact), relationship with arterial structures, deviation from the midline, volume (cm3), degree of initial edema, WHO histological classification, degree of atypia, degree of resection, previous embolization, and development of complications. The edema levels were classified according to the classification described by Ide et al. (1995): GR0, GR1, and GR2. Measurements were performed using FLAIR magnetic resonance sequences. Statistical analyses were performed using the SPSS 21. Results: Age (p=0.003), deviation from the midline (p=0.001), and tumor volume (p<0.001) were correlated with outcome using Spearman's test. Univariate analysis revealed that the localization (p=0.016), initial edema (p<0.001), degree of atypia (p=0.019), and presence of previous embolization (p=0.037) were statistically significant. In multivariate analysis, only age, initial edema, and embolization were significant independent predictors. Conclusion: These results suggest that the degree of initial edema, midline deviation, tumor volume, tumor location, degree of atypia, and previous embolization may be important predictors of postoperative edema duration.
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Nie, Daotai. Targeting Tumor Oct4 to Deplete Prostate Tumor and Metastasis Initiating Cells. Fort Belvoir, VA: Defense Technical Information Center, Oktober 2014. http://dx.doi.org/10.21236/ada613791.

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10

Kengsakul, Malika, Gatske Nieuwenhuyzen – de Boer und Heleen van Beekhuizen. Radiological factors associated with residual disease after cytoreductive surgery for advanced ovarian cancer. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Januar 2023. http://dx.doi.org/10.37766/inplasy2023.1.0059.

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Review question / Objective: Which radiological factors associated with incomplete cytoreduction (gross residual disease) after cytoreductive surgery (CRS) for advanced ovarian cancer? Condition being studied: Findings of CT scan and discussion in the multidisciplinary tumor board meeting (MDO) are crucial to determine the therapeutic strategy for individual ovarian cancer patients. Preferably, patients undergo primary cytoreductive surgery (CRS) followed by adjuvant chemotherapy. However, when complete cytoreduction is not considered feasible, neoadjuvant chemotherapy followed by interval cytoreductive surgery and adjuvant chemotherapy is indicated. In patients with advanced stage epithelial ovarian cancer (EOC), maximal cytoreduction to no gross residual tumor (complete cytoreduction) is known to associated with the best overall survival.
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