Thematische Bibliographien / Triterpenoilds

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Auswahl der wissenschaftlichen Literatur zum Thema „Triterpenoilds“

Autor: Grafiati

Veröffentlicht am 18. Mai 2024

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Zeitschriftenartikel zum Thema "Triterpenoilds"

Wen, Cuiping, Zhong Zhang, Qianqian Shi, Xiaoshan Duan, Jiangtao Du, Cuiyun Wu und Xingang Li. „Methyl Jasmonate- and Salicylic Acid-Induced Transcription Factor ZjWRKY18 Regulates Triterpenoid Accumulation and Salt Stress Tolerance in Jujube“. International Journal of Molecular Sciences 24, Nr. 4 (15.02.2023): 3899. http://dx.doi.org/10.3390/ijms24043899.

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Triterpenoids are important, pharmacologically active substances in jujube (Ziziphus jujuba Mill.), and play an important role in the plant’s resistance to abiotic stress. However, regulation of their biosynthesis, and the underlying mechanism of their balance with stress resistance, remain poorly understood. In this study, we screened and functionally characterized the ZjWRKY18 transcription factor, which is associated with triterpenoid accumulation. The transcription factor is induced by methyl jasmonate and salicylic acid, and its activity was observed by gene overexpression and silencing experiments, combined with analyses of transcripts and metabolites. ZjWRKY18 gene silencing decreased the transcription of triterpenoid synthesis pathway genes and the corresponding triterpenoid content. Overexpression of the gene promoted the biosynthesis of jujube triterpenoids, as well as triterpenoids in tobacco and Arabidopsis thaliana. In addition, ZjWRKY18 binds to W-box sequences to activate promoters of 3-hydroxy-3-methyl glutaryl coenzyme A reductase and farnesyl pyrophosphate synthase, suggesting that ZjWRKY18 positively regulates the triterpenoid synthesis pathway. Overexpression of ZjWRKY18 also increased tolerance to salt stress in tobacco and Arabidopsis thaliana. These results highlight the potential use of ZjWRKY18 to improve triterpenoid biosynthesis and salt stress tolerance in plants, and provide a strong basis for metabolic engineering to improve the content of triterpenoids and breeding of jujube varieties that are resistant to stress.

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Sun, Caowen, Shengzuo Fang und Xulan Shang. „Triterpenoids Biosynthesis Regulation for Leaf Coloring of Wheel Wingnut (Cyclocaryapaliurus)“. Forests 12, Nr. 12 (09.12.2021): 1733. http://dx.doi.org/10.3390/f12121733.

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Cyclocaryapaliurus leaves are rich in triterpenoids with positive results in the treatment of diabetes, antioxidation, and scavenging free radicals. C. paliurus red leaves have been found to contain higher flavonoids including anthocyanin, however, the triterpenoids accumulation pattern is still unclear. For the purpose of researching the triterpenoid accumulating mechanism during red new leaf development, transcriptome and metabolome analysis was conducted during C. paliurus the red leaf development process. The results uncovered that most triterpenoid ingredients were found to accumulate during leaves turning green, while the unique ingredients content including cyclocaric acid A, cyclocarioside I, cyclocarioside Ⅱand cyclocarioside Ⅲ decreased or remained unchanged. Functional structure genes (hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-CoA reductase, and farnesyl-diphosphate synthase) were identified for promoting triterpenoids accumulation mainly in the mevalonic acid pathway (MVA). Moreover, glycosyltransferase (UGT73C, UGT85A, and UGT85K) was also found attributed to triterpenoids accumulation. These findings provide information for a better understanding of the triterpenoid biosynthesis mechanism during leaf development and will be useful for targeted breeding.

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Kim, Jaecheol, Si Chang Yang, Ah Young Hwang, Hyunnho Cho und Keum Taek Hwang. „Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines“. Molecules 25, Nr. 18 (06.09.2020): 4066. http://dx.doi.org/10.3390/molecules25184066.

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The objective of this study was to determine the composition of triterpenoids in the extracts from the inner and outer parts of Inonotus obliquus and to evaluate their anti-proliferative activity against cancer cell lines (HT-29, AGS, MCF-7, and PC3). Inner and outer parts of I. obliquus were extracted with 80% methanol for 24 h. The extract was fractionated by Diaion HP-20 resin to obtain the triterpenoid fraction. Composition of triterpenoids in the fraction was analyzed by HPLC and LC-ESI-MS. Anti-proliferative activity was evaluated by MTT assay against cancer cell lines. Inotodiol and trametenolic acid were major triterpenoids in both of the inner and outer parts of I. obliquus. Inotodiol in triterpenoid fractions from the inner and outer parts of I. obliquus was 153.9 ± 15.4 mg/g (dry basis (db)) and 194.1 ± 11.5 mg/g, respectively. Trametenolic acid in triterpenoid fractions from the inner and outer parts of I. obliquus was 94.5 ± 9.15 mg/g (db) and 106.3 ± 8.23 mg/g, respectively. Triterpenoids in the outer part were significantly higher than those in the inner part. Anti-proliferative activity of the triterpenoid fraction from the outer part against AGS, MCF-7, and PC3 was also significantly higher than that of the inner part.

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Aliffia Dwi Rahma, Hanifah Ismayfatin, Yulianti Khasanah, Aditiya Rizky Putra Abimanyu und Himyatul Hidayah. „Identification of Tannin, Triterpenoid, and Flavonoid Function Groups of Jamblang Plants (Syzygium cumini): A Systematic Literature Review“. Eureka Herba Indonesia 5, Nr. 1 (15.12.2023): 377–82. http://dx.doi.org/10.37275/ehi.v5i1.102.

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Identification of the functional groups of tannins, triterpenoids, and flavonoids in jamblang is important to determine the type and content of bioactive compounds found in jamblang. By knowing the type and content of these bioactive compounds, the potential of jamblang as a traditional medicine can be further optimized. This study aims to explore the identification of tannin, triterpenoid, and flavonoid functional groups in jamblang. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the identification of tannin, triterpenoid, and flavonoid functional groups in jamblang (Syzygium cumini). This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Jamblang contains various types of tannins, including catechins, gallotanins, and proanthocyanidins. Jamblang contains various types of triterpenoids, including phytosterols, triterpenoid saponins, and other triterpenoids. Jamblang contains various types of flavonoids, including flavonols, flavanones, and anthocyanins.

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Chang, Te-Sheng, Chien-Min Chiang, Tzi-Yuan Wang, Yu-Li Tsai, Yu-Wei Wu, Huei-Ju Ting und Jiumn-Yih Wu. „One-Pot Bi-Enzymatic Cascade Synthesis of Novel Ganoderma Triterpenoid Saponins“. Catalysts 11, Nr. 5 (30.04.2021): 580. http://dx.doi.org/10.3390/catal11050580.

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Ganoderma lucidum is a medicinal fungus whose numerous triterpenoids are its main bioactive constituents. Although hundreds of Ganoderma triterpenoids have been identified, Ganoderma triterpenoid glycosides, also named triterpenoid saponins, have been rarely found. Ganoderic acid A (GAA), a major Ganoderma triterpenoid, was synthetically cascaded to form GAA-15-O-β-glucopyranoside (GAA-15-G) by glycosyltransferase (BtGT_16345) from Bacillus thuringiensis GA A07 and subsequently biotransformed into a series of GAA glucosides by cyclodextrin glucanotransferase (Toruzyme® 3.0 L) from Thermoanaerobacter sp. The optimal reaction conditions for the second-step biotransformation of GAA-15-G were found to be 20% of maltose; pH 5; 60 °C. A series of GAA glucosides (GAA-G2, GAA-G3, and GAA-G4) could be purified with preparative high-performance liquid chromatography (HPLC) and identified by mass and nucleic magnetic resonance (NMR) spectral analysis. The major product, GAA-15-O-[α-glucopyranosyl-(1→4)-β-glucopyranoside] (GAA-G2), showed over 4554-fold higher aqueous solubility than GAA. The present study demonstrated that multiple Ganoderma triterpenoid saponins could be produced by sequential actions of BtGT_16345 and Toruzyme®, and the synthetic strategy that we proposed might be applied to many other Ganoderma triterpenoids to produce numerous novel Ganoderma triterpenoid saponins in the future.

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Liu, Zengcai, Ruipeng Liu, Xinyu Tong und Li Zou. „New Insights into Methyl Jasmonate Regulation of Triterpenoid Biosynthesis in Medicinal Fungal Species Sanghuangporusbaumii (Pilát) L.W. Zhou & Y.C. Dai“. Journal of Fungi 8, Nr. 9 (23.08.2022): 889. http://dx.doi.org/10.3390/jof8090889.

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Triterpenoids are secondary metabolites produced by the fungus Sanghuangporus baumii that have important pharmacological activities. However, the yield of triterpenoids is low and cannot meet market demand. Here, we treated S. baumii with several concentrations of MeJA (methyl jasmonate) and found that the total triterpenoid content was highest (23.31 mg/g) when the MeJA concentration was 250 μmol/L. qRT-PCR was used to quantify the transcription of five key genes involved in triterpenoid biosynthesis. The results showed that the relative transcription of most genes increased with increasing MeJA concentration, indicating that MeJA is a potent inducer of triterpenoid biosynthesis in S. baumii. To further explore whether other terpenoid biosynthesis pathways are also involved in the accumulation of triterpenoids induced by MeJA, we measured the contents of cis-Zeatin (cZ), gibberellins (GAs), and the transcript levels of related biosynthesis genes. We found that MeJA significantly inhibited the biosynthesis of cZ, GAs, and the transcription of related genes. The repressive effects of MeJA on cZ and GA accumulation were further confirmed by growth rate and biomass assays. In conclusion, our study provides an effective method to enhance the triterpenoid content of S. baumii, and also provides novel insights into the mechanism of MeJA-induced triterpenoid biosynthesis.

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Numonov, Sodik, Farukh Sharopov, Muhammad Nasimullah Qureshi, Latofat Gaforzoda, Isomiddin Gulmurodov, Qosimjon Khalilov, William N. Setzer, Maidina Habasi und Haji Akber Aisa. „The Ursolic Acid-Rich Extract of Dracocephalum heterophyllum Benth. with Potent Antidiabetic and Cytotoxic Activities“. Applied Sciences 10, Nr. 18 (18.09.2020): 6505. http://dx.doi.org/10.3390/app10186505.

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Pentacyclic triterpenoids are one of the main functional components in Dracocephalum heterophyllum. In this study the optimal process, the fairly simple and accessible extraction and purification of triterpenoids of D. heterophyllum, was developed by a remaceration method. Remaceration is characterized by minimal loss of biologically active compounds on diffusion, which contributes to the largest depletion of raw materials. The triterpenoid yield was 2.4% under optimal conditions which was enhanced to 98.03% after purification. The triterpenoid profiles and their anticancer and antidiabetic activities were further analyzed. GC-MS analysis of triterpenoidal extract of D. heterophyllum resulted ursolic acid (71.9%) and oleanolic acid (18.1%) as the major components. Additionally, total purified triterpenoid contents of D. heterophyllum and its main components were shown to possess significant cytotoxic activity against three human breast cancer cell lines (SK-Br-3, T47D, and MCF-7). The purification of triterpenoids influenced their biological activity. The antidiabetic effect, as measured by inhibition of protein-tyrosine phosphatase (PTP-1B), of the purified fraction of triterpenoids of D. heterophyllum increased by five-fold against the enzyme. The results provide important guidance for the industrial application of D. heterophyllum confirming the prospect of developing plant extracts into effective drugs and health foods for human applications.

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Si, Longlong, Kun Meng, Zhenyu Tian, Jiaqi Sun, Huiqiang Li, Ziwei Zhang, Veronica Soloveva et al. „Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes“. Science Advances 4, Nr. 11 (November 2018): eaau8408. http://dx.doi.org/10.1126/sciadv.aau8408.

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A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its constitutive heptad repeat-2 (HR2), a prevalent α-helical coil in class I viral fusion proteins. Triterpenoids inhibit the entry of Ebola, Marburg, HIV, and influenza A viruses with distinct structure-activity relationships. Specifically, triterpenoid probes capture the viral envelope via photocrosslinking HR2. Profiling the Ebola HR2-triterpenoid interactions using amino acid substitution, surface plasmon resonance, and nuclear magnetic resonance revealed six residues accessible to triterpenoids, leading to wrapping of the hydrophobic helix and blocking of the HR1-HR2 interaction critical in the trimer-of-hairpins formation. This finding was also observed in the envelopes of HIV and influenza A viruses and might potentially extend to a broader variety of viruses, providing a mechanistic insight into triterpenoid-mediated modulation of viral fusion.

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Xu, Hou-Chao, Kun Hu, Xiao-Huo Shi, Jian-Wei Tang, Xiao-Nian Li, Han-Dong Sun und Pema-Tenzin Puno. „Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea“. Organic Chemistry Frontiers 6, Nr. 10 (2019): 1619–26. http://dx.doi.org/10.1039/c9qo00281b.

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Liang, Xiaoqin, Peng Niu, Jun Li, Xinlan Guan, Yanjun Zhang und Jian Li. „Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand“. Molecules 28, Nr. 4 (09.02.2023): 1658. http://dx.doi.org/10.3390/molecules28041658.

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Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC50 value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.

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Dissertationen zum Thema "Triterpenoilds"

MacKinnon, Shawna. „Bioactive triterpenoids of the Rutales“. Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9678.

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This thesis describes the investigation of the bioactivity of triterpenoids, limonoids and spiro-triterpenoids, isolated from the order of the Rutales. The focus of this research has been towards the development of botanical insecticides with non-neurotoxic modes of action in insects. It follows the recent development of Neem (Azadirachta indica, Meliaceae) as a botanical insecticide containing a limonoid azadirachtin as its main active compound. Because so few Meliaceae members have been examined for insecticidal activity the project was initiated by the screening of over sixty ethanol extracts of various parts of twenty species (collected from Costa Rica and the Tropical Museum in Miami, Florida) for bioactivity against the European corn borer (Ostrinia nubilalis) and the Variegated cutworm (Peridroma saucia). The data suggest that a majority of the extracts studied inhibited growth significantly; some are more active than neem leaf extracts. Swietenia mahogani bark, Trichilia glabra bark, T. hirta leaves, T. americana bark, T. trifolia wood, T. pleana and Azadirachta indica wood showed potent activity against the cutworm. Ruptiliocarpon caracolito bark, Cedrela odorata leaves, Aphanamixis polystachys wood, T. glabra wood and T. pleana bark showed good activity against the corn borer larvae. Bioassay guided fractionation of the most active crude extract, the bark of Ruptiliocarpon caracolito, has resulted in the isolation of six very novel spiro-CD-triterpenoids, the spirocaracolitones. The spirocaracolitones, at 100 ppm, were screened for antifungal activity against Fusarium using a hyphal growth bioassay. After 48 h a high degree of inhibition of growth (59-79%) was observed. These novel triterpenoids exhibited no antimalarial activity when screened against Plasmodium falciparum. A study of the effects of these compounds, incorporated into artificial diet, on the neonate life cycle of the European corn borer was conducted. All the spirocaracolitones effected the growth and the development of the insects but spirocaracolitone B and spirocaracolitone C were substancially more active than the other spirocaracolitones. Two postulates dealing with the biosynthesis of these unique spiro-compounds are also presented. Both commence with a friedelin derivative because canophyllol was isolated in large quantities from the hexane extract. They envisage generation of a carbocation at C12 followed by migration of the C23 methyl group this results in the formation of a carbocation at C13. The spirosystem results from migration of the C8-C14 bond. An investigation of the structure/activity relationships of gedunin was conducted to determine the moieties responsible for its antimalarial and/or antifeedant properties. Ten derivatives of gedunin were prepared (1,2-dihydrogedunin, 1,2-epoxygedunin, 1,2-dihydro-3$\beta$-gedunol, 3$\beta$-acetoxy-1,2-dihydrogedunin, 7-deacetylgedunin, 7-ketogdunin, hexahydrogedunin, tetrahydrogedunin, 21-acetylgedunin, 23-acetylgedunin) along with five other limonoids (limonin, epilimonol, nomilin, obacunone, hirtin) closely related to gedunin were evaluated for antifeedant activity (Ostrinia nubilalis) and antimalarial activity (Plasmodium falciparum). Evaluation of these compounds for antimalarial activity presented no increase in activity however it was clearly determined that alterations to the enone in ring A and at C7 of gedunin resulted in large losses of activity. Evaluation of the effects of these limonoids on the neonate life cycle of the European corn borer at 5 and 50 ppm incorporation into the artificial diet did lot produced dramatic effects on the growth and development of the larvae. At these concentrations structure/activity relationships could not be proposed.$\sp*$ ftn$\sp*$Please refer to the dissertation for diagrams.

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Chen, Ying. „Determination of triterpenoids in Psidium guajava“. Thesis, University of Macau, 2012. http://umaclib3.umac.mo/record=b2590321.

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Hayasida, Willian. „Investigação química das folhas e galhos de Guarea convergens (Meliaceae)“. Universidade Federal do Amazonas, 2011. http://tede.ufam.edu.br/handle/tede/4417.

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The Meliaceae family comprises has about 50 genus and approximately 700 species, generally arboreus, occurring in regions Pantropical. The predominant metabolites in the family are triterpenoids with cycloartane, dammarane, tirucallane and apotirucallane skeleta, further degraded triterpenoids (limonoids and steroids). The genus Guarea possesses about 50 species however chemical studies are limited to ten species, whose reports are sesquiterpenes, diterpenes and triterpenes (cycloartane, tirucallane lanostane and apotirucallane), further limonoids. Although the occurrence of approximately 30 species of Guarea in Amazon have few relates on chemical studies, this acted as stimulus for our investigation about Guarea convergens T.D. occurrent in Amazon. Thus, leaves and branches collected in the Adolpho Ducke Forest Reserve were submitted to maceration to obtain the organic extracts. The chromatographic fractionning of the CH2Cl2 and MeOH leaves extracts led to the isolation of apotirucallane triterpenes: the 24R-acetoxy,25-hydroxy-3,7-dioxo-apotirucalla-14-en-21,23- olide (1) and the 7a,24R,25-trihydroxy-3-oxo-apotirucalla-14-en-21,23-olide (4), steroids: ergosta-5,24-diene-3 ,4 ,22S-triol (2) and ergosta-5,24-diene-3 ,7 -21-triol (3). The compounds 1, 3 and 4 are being reported for first time. The CH2Cl2 branches extract yielded a mixture of steroids (b-sitosterol and stigmasterol, 5) and the tirucallane triterpenes namely melianone (6) and melianodiol (7). This is the first chemical study effected with species G. convergens whose isolated and identified compound provide contributions to knowledge of the chemosystematic of the Rutales order.
A família Meliaceae possui cerca 50 gêneros e aproximadamente 700 espécies, geralmente arbóreas de ocorrência nas regiões Pantropicais. Os metabólitos predominantes na família são os triterpenos com esqueletos cicloartano, damarano, tirucalano e apotirucalano além dos triterpenos degradados (limonóides e esteróides). O gênero Guarea apresenta cerca de 50 espécies, no entanto os estudos químicos são limitados a dez espécies cujos relatos são de sesquiterpenos, diterpenos e triterpenos (cicloartano, tirucalano, lanostano e apotirucalano), além dos limonóides. Apesar da ocorrência de aproximadamente 30 espécies de Guarea no Amazonas, existem poucos relatos sobre os estudos químicos, o que nos estimulou a seleção de G. convergens ocorrente no Amazonas. Assim, folhas e galhos coletados na Reserva Florestal Adolfo Ducke foram submetidos à maceração para obtenção dos extratos orgânicos. O fracionamento cromatográfico dos extratos CH2Cl2 e MeOH de folhas resultou no isolamento dos triterpenos com esqueleto apotirucalano, 24R-acetoxi-25-hidroxi-3,7-oxoapotirucala- 14-en-21,23-olideo (1) e 7a,24R,25-trihidroxi-3-oxo-apotirucala-14-en-21,23- olideo (4) e dos esteróides do tipo ergostano, ergosta-5,24-dieno-3 ,4 ,22S-triol (2) e ergosta-5,24-dieno-3 ,7a,21-triol (3). As substâncias 1, 3 e 4 estão sendo relatadas pela primeira vez. Nos extratos dos galhos, além de -sitosterol (5) foram isolados os triterpenos do tipo tirucalano, melianona (6) e melianodiol (7). Esse é o primeiro estudo químico da espécie G. convergens cujos compostos isolados e identificados fornecem contribuições para o conhecimento da quimiossistemática da ordem Rutales.

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Perkins, Gemma. „Studies on the preparation of pentacyclic triterpenoids“. Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294547.

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Harris, Katherine S. M. Massachusetts Institute of Technology. „Diversity of polycyclic triterpenoids in Rhodospirillum rubrum“. Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/58195.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 22-24).
Sedimentary rocks of all ages abound with geostable lipids of microbial origin, but many biomarkers lack known organismal sources and clear environmental contexts. Here we used Rhodospirillum rubrum, a metabolically versatile, genetically tractable c-Proteobacterium, to explore the diversity of its non-polar terpenoids as a function of growth condition and growth phase. We analyzed the nonpolar fraction of lipids extracted from R. rubrum grown under aerobic, anaerobic, heterotrophic and phototrophic conditions and detected a variety of bicyclic, tricyclic, tetracyclic and pentacyclic triterpenoids, derived from the enzymatic cyclization of squalene and produced in amounts comparable to diploptene. Identified compounds included bicyclic polypodatetraenes, malabaricatriene, euphadiene, adianane, and fernene. Prior to this work, malabaricatriene was an "orphan" biomarker suspected to have a microbial origin, yet it lacked a proven source. We observed similar patterns of polycyclic terpenoids in other hopanoid-producing c-proteobacteria, including Zymomonas mobilis, Rhodopseudomonas palustris, and Rhodomicrobium vannielii. The presence and relative abundance of polycyclic triterpenoids in R. rubrum varied with the growth stage (exponential versus early stationary phase) and growth condition (photoheterotrophic versus photoautotrophic growth). Since R. rubrum's genome contains a single squalene-hopene cyclase gene, the array of triterpenoids produced by it and other c-proteobacteria likely evolves from this enzyme performing low-fidelity cyclization. The observed diversity of sedimentary triterpenoids might therefore result from a select few squalene-hopene cyclase enzymes operating with varying specificity under a range of physiological and environmental conditions, rather than reflecting a great diversity of squalene-hopene cyclases.
by Katherine Harris.
S.M.

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Papineni, Sabitha. „New synthetic derivatives of triterpenoids in the treatment of cancer“. [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3252.

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Smith, Zena Elizabeth Florence. „Characterisation of A-ring contracted triterpenoids in oils and shales : evidence for an alternative transformation pathway in the diagenesis of higher plant triterpenoids“. Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294960.

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Clement, Jason Anderson. „Studies of Bioactive Natural Products and Mechanism-Based Bioassays“. Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/29879.

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An extract of the sponge Rhabdastrella globostellifera was active in an assay measuring stabilization of the binding of DNA with DNA polymerase β. From this extract, four isomalabaricane triterpenoids were isolated and characterized, three of which were active in the binding assay. All compounds were active in the A2780 ovarian cancer cell line assay. Bioassay-guided fractionation of an extract of a sponge of species Dysidea using the A2780 bioassay yielded the known scalarane sesterterpenoid heteronemin in good yield. Four derivatives of heteronemin were prepared semisynthetically from the natural product, tested for their bioactivity, and their structure-activity dependence was observed. Bioassay guided-fractionation of an extract of a Tuemoya sp. green alga, using an assay for inhibitors of the enzyme Tie2 kinase, afforded a two sulfated cycloartanol triterpenoids. Both the major and minor compounds were identified by spectroscopic methods. Bioassay-guided fractionation of an extract of Petalonyx parryi yielded three known oleanane triterpenoids which inhibited the lyase domain of DNA polymerase β. The structures were confirmed by NMR spectroscopic techniques. This is the first reported study of the chemical components of Petalonyx parryi. As part of our antitumor natural product drug discovery efforts, several extracts were selected for bioassay-guided fractionation based on their activity in initial in vitro screens. A new dereplication method using aminopropyl SPE cartridges was applied to six of these extracts, and four of the extracts were dropped due to the presence of long-chain fatty acids (LCFAs). We present results for the testing and application of this SPE-based method for LCFA dereplication. The cell cycle kinase Chk1 is an interesting target for the development of agents which might potentiate DNA damaging agents. Typical assays for Chk1 involve the use of expensive or radioactive reagents. To facilitate the development of new assays using shorter peptide substrates, small libraries of peptides have been synthesized and tested for their activity as Chk1 substrates. Several of the substrates synthesized displayed activity in the Chk1 assay.
Ph. D.

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Xie, Nan. „Extraction of triterpenoids saponins from Australian plant using supercritical fluids“. Thesis, The University of Sydney, 2010. https://hdl.handle.net/2123/28852.

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It has been identified that triterpenoids saponins extracted from plants can have cardiovascular, antitumor, and anti-inflammatory activities. The Australian Acacia plant has a broad range of triterpenoids saponins. Current methods for separation and isolation of triterpenoids saponins involve using a large amount of organic solvents, which can be a drawback of using the extract as a functional food and nutraceutical.

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Reed, James. „Transient expression for engineering triterpenoid diversity in plants“. Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/67059/.

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The triterpenes are one of the largest and most structurally diverse classes of plant specialised metabolites, with important commercial, agronomical and medical potential. However the structural complexity and low abundance of these compounds in nature presents significant challenges for exploiting this diversity. In recent years, advances in our understanding of triterpene biosynthesis in various plant species have greatly facilitated the ability to produce these compounds in other hosts. Plant-based host systems hold great promise because they may provide substrates, cofactors and subcellular compartmentalisation mechanisms facilitating engineering production of complex triterpenoids. Agroinfiltration is a rapid and scalable process that enables transient expression of biosynthetic genes in amenable plants such as Nicotiana benthamiana. This technique holds great promise for selective production and modification of triterpenes, but studies in this area have been limited. In this PhD thesis, transient expression is used to produce and oxidise triterpenes in N. benthamiana. Triterpene yields are improved through expression of rate-limiting genes in the mevalonate pathway (Chapter 3). An enzymatic ‘toolkit’ is established from a collection of previously characterised triterpene biosynthetic genes, allowing production of milligram quantities of a diverse array of simple and oxidised triterpenes in N. benthamiana. Furthermore, combinatorial biosynthesis is utilised to engineer production of novel oxidised triterpenes in planta (Chapter 4). A set of oxidised derivatives of β-amyrin are purified and evaluated for antiproliferative and anti-inflammatory activity in human cell lines, yielding insights into structural features underlying these activities in humans (Chapter 5). Finally, N. benthamiana is used for functional screening of cytochrome P450s implicated in the biosynthesis of agronomically important antifungal triterpene glycosides (avenacins) in oat, leading to identification of new P450s required for disease resistance (Chapter 6). This work highlights the utility of N. benthamiana as triterpene engineering platform and provides a basis for future studies exploring triterpene structure-activity relationships.

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Bücher zum Thema "Triterpenoilds"

Dev, Sukh. CRC handbook of terpenoids--Triterpenoids. Boca Raton, Fla: CRC Press, 1989.

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1923-, Dev Sukh, Hrsg. CRC handbook of terpenoid. Triterpenoids. Boca Roton, Pl: CRC Press, 1989.

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S, Levin V., und Stonik V. A, Hrsg. Khimicheskai͡a︡ morfologii͡a︡: Triterpenovye glikozidy goloturiĭ (Holothurioidea, Echinodermata). Vladivostok: Dalʹnauka, 1994.

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State University College at Buffalo. Dept. of Art Conservation. und MOLART (Project), Hrsg. Molecular studies of fresh and aged triterpenoid varnishes. [Amsterdam: MOLART, 1999.

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Huspa, Desi Harneti Putri. Triterpenoid yang bersifat antimalaria dari tumbuhan meliaceae Indonesia: Laporan akhir penelitian hibah penelitian strategi nasional. Bandung]: Departemen Pendidikan Nasional, Universitas Padjadjaran, Fakultas Matematika dan Ilmu Pengetahuan Alam, 2010.

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Dev, Sukh. Handbook of Terpenoids : Volume I: Triterpenoids. Taylor & Francis Group, 2018.

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Dev, Sukh. Handbook of Terpenoids : Volume I: Triterpenoids. Taylor & Francis Group, 2018.

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Qin, Hailin, und Dequan Yu. Diterpenoids, Triterpenoids, Sesterterpenoids, Tetraterpenoids, and Carotenoids. De Gruyter, 2021. http://dx.doi.org/10.1515/9783110634723.

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Dev, Sukh. Handbook of Terpenoids : Volume I: Triterpenoids. Taylor & Francis Group, 2018.

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Yu, Dequan, Hailin Qin und Chemical Industry Chemical Industry Press. Diterpenoids, Triterpenoids, Sesterterpenoids, Tetraterpenoids, and Carotenoids. de Gruyter GmbH, Walter, 2021.

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Buchteile zum Thema "Triterpenoilds"

Pengelly, Andrew. „Triterpenoids and saponins.“ In The constituents of medicinal plants, 95–111. 3. Aufl. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789243079.0006.

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Abstract This chapter focuses on the various classes of triterpenoids (free triterpenes, triterpenoid saponins, steroidal saponins, cardiac glycosides, phytosterols, phytoecdysteroids, curcurbitacins and quassinoids), which occur in the free state within plants or as aglycones of glycosides. Information on the chemical structures and pharmacological actions of these triterpenoids and saponins are also presented.

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Connolly, J. D., und R. A. Hill. „Triterpenoids“. In Dictionary of Terpenoids, 1119–415. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-4513-6_6.

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Dwivedi, Ram Snehi. „Triterpenoids“. In Alternative Sweet and Supersweet Principles, 323–88. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-33-6350-2_8.

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Deng, Jianjun, Jianbo Xiao und Haixia Yang. „Dietary Triterpenoids“. In Handbook of Dietary Phytochemicals, 1–53. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1745-3_15-1.

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Deng, Jianjun, Jianbo Xiao und Haixia Yang. „Dietary Triterpenoids“. In Handbook of Dietary Phytochemicals, 423–75. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-4148-3_15.

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Mahato, S. B., und S. Garai. „Triterpenoid Saponins“. In Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, 1–196. Vienna: Springer Vienna, 1998. http://dx.doi.org/10.1007/978-3-7091-6496-9_1.

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Gütz, P. G. „Triterpenoids in Epicuticular Waxes“. In Biological Role of Plant Lipids, 325–28. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-1303-8_75.

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Cheng, Yongxian, und Dapeng Qin. „Classification of Diverse Triterpenoids“. In Novel Plant Natural Product Skeletons, 49–63. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-7329-3_5.

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Sahoo, Biswa Mohan, Bimal Krishna Banik und Abhishek Tiwari. „Synthesis and Medicinal Uses of Triterpenoids“. In Terpenoids, 285–329. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003008682-9.

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Skrukrud, C. L., S. E. Taylor, D. R. Hawkins und M. Calvin. „Triterpenoid Biosynthesis in Euphorbia Lathyris“. In The Metabolism, Structure, and Function of Plant Lipids, 115–18. Boston, MA: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4684-5263-1_18.

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Konferenzberichte zum Thema "Triterpenoilds"

Kinaci, Emre, John Chea, Kirti Yenkie und Kylie Howard. „Converting Birch Bark Extracts into Bio-based Thermosets“. In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/wcih1760.

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Birch tree barks are regarded as waste in the pulp and papermaking industry and used as fuel. However, this material presents a source that contains many bio-based chemicals suitable for applications ranging from pharmaceuticals, plastics and composites, coatings, and antifeedants. Among the mixture of bio-derived chemicals in birch barks, triterpenoids, such as betulin, betulinic acid, and lupeol, can be present up to 30% weight of dry bark mass. They are highly valued for their anti-tumor, HIV, and inflammatory responses. In our presented work, triterpenoid mixtures were extracted through a Soxhlet extractor using the barks from locally sourced river birch trees (Betula nigra) with an average yield of 10.6% (dry bark mass). The extracted materials were characterized using the Nuclear Magnetic Resonance (NMR), Advanced Polymer Chromatography (APC), High-Performance Liquid Chromatography (HPLC), and hydroxyl number titration to assess the identity, average molecular weight, triterpenoid content, and the number of reactive sites, respectively. The extracts have been used to synthesize bio-based polymers with promising thermal and mechanical properties using minimal processing steps. Birch bark extract naturally contains many potential reactive sites and thus making it advantageous for synthesizing polymers without requiring multiple purification steps. We demonstrate the potentials for increasing the utility of birch bark, contributing to sustainability challenges in materials science and engineering.

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Faraoni, María, María Castro und Ana Murray. „Lupane Triterpenoids, Selective Butyrylcholinesterase Inhibitors“. In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-b035.

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Luchnikova, N. A., K. M. Ivanova, E. V. Tarasova, V. V. Grishko und I. B. Ivshina. „ACTINOBACTERIAL TRANSFORMATION OF OLEANANE TRITERPENOIDS“. In Фундаментальные и прикладные аспекты биоинформатики, биотехнологии и недропользования. Пермский государственный национальный исследовательский университет, 2021. http://dx.doi.org/10.17072/fpabbn-2021-5-7.

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Valdes, Alberto, Alejandro Cifuentes, Jose David Sanchez-Martinez, Miguel Herrero, Rocio Gallego und Zully Suarez-Montenegro. „Foodomics study of the neuroprotective potential of natural products“. In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/bdyo8801.

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Worldwide, around 50 million people have dementia with nearly 10 million new cases every year. Alzheimer’s Disease (AD) is the most common form of dementia, and it may contribute to 60–70 % of these cases. This multifactorial pathophysiology has been widely characterized by neuroinflammation, extensive oxidative damage, synaptic loss and neuronal cell death. However, only a few drugs have been approved for the therapeutic treatment of AD (with unpleasant side effects), and many studies have suggested that diet and/or food components can prevent the onset of AD. Among these constituents, terpenoids and carotenoids from diverse natural sources have been investigated, and based on a Foodomics approach, our group has demonstrated that an olive leaves extract enriched in triterpenoids and a carotenoids-enriched extract from Dunaliella salina microalgae have neuroprotective potential using in vitro assays. In addition, the neuroprotective and anti-inflammatory potential of these extracts have been confirmed in a neuronal in vitro cell culture model and in vivo using a transgenic Caenorhabditis elegans model. Moreover, different lipidomics studies were performed using advanced analytical methodologies, namely, charged-surface hybrid chromatography-quadrupole-time of flight mass spectrometry (CSH-Q-TOF MS/MS). This technology allowed the annotation of more than 250 intracellular lipids, and among them, a number of phosphatidylcholines, phosphatidylethanolamines and triacylglycerols were significantly altered, suggesting triterpenoids from olive leaves and carotenoids from microalgae as good neuroprotective candidates.

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Gao, Jie, Kenza Mamouni, Georgios Kallifatidis, Siva Panda, Muthusamy Thangaraju und Bal L. Lokeshwar. „Abstract 5069: Breast cancer prevention by triterpenoids from allspice“. In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5069.

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Kazakova, O. B., und I. E. Smirnova. „Antiviral activity of lupane and oleanane A-seco-triterpenoids“. In ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0069236.

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Konysheva, Anastasia V., und Victoria V. Grishko. „SAR analysis and bioactive potential of C(3) alkylated triterpenoids“. In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018484.

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Rodriguez-Lopez, Fidel, Edgar G. Rodríguez-García, Hugo A. García-Gutiérrez und Rocío Gámez-Montaño. „Plant-Derived Triterpenoid Functionalization: Synthesis of α-Acyloxycarboxamides“. In ECSOC 2023. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/ecsoc-27-16061.

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Dzubak, Petr, Renata Burianova, Martina Michalova, Barbora Liskova, Milan Urban, Jan Sarek, Adela Galandakova, Jitka Ulrichova und Marian Hajduch. „Abstract 2077: Carbonate prodrugs derived from triterpenoids with high cytotoxic activity“. In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2077.

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Berichte der Organisationen zum Thema "Triterpenoilds"

Sporn, Michael B. Triterpenoids and Prevention of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, Oktober 2001. http://dx.doi.org/10.21236/ada405249.

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Sporn, Michael B. Triterpenoids and Prevention of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, Oktober 1999. http://dx.doi.org/10.21236/ada384364.

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Hawkins, D. R. Triterpenoid biosynthesis in Euphorbia lathyris latex. Office of Scientific and Technical Information (OSTI), November 1987. http://dx.doi.org/10.2172/5625757.

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Hyer, Marc L. Modulating TRAIL-Mediated Apoptosis in Prostate Cancer Using Synthetic Triterpenoids. Fort Belvoir, VA: Defense Technical Information Center, Januar 2005. http://dx.doi.org/10.21236/ada434105.

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Schaffer, Arthur A., und Jocelyn Rose. Understanding Cuticle Development in Tomato through the Study of Novel Germplasm with Malformed Cuticles. United States Department of Agriculture, Juni 2013. http://dx.doi.org/10.32747/2013.7593401.bard.

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Plant cuticle development and metabolism are still poorly understood, partly due to the chemical complexity of the cuticular layer. The overall research objective was to broaden and deepen our understanding of tomato fruit cuticle development by analyzing novel germplasm with cuticular malformations and by studying the transcriptome and proteome of the fruit epidermal tissues, as strategies to overcome the challenges posed by the recalcitrance of the biological system. During the project we succeeded in identifying two genes with major impact on cuticle development. One of these encoded the first cutin synthase to be identified in plants, a metabolic step that had been a black box in cutin synthesis. In addition genes controlling the triterpenoid components of the cuticle were identified and, most interestingly, genetic variability for this component was identified among the wild tomato species germplasm. Additional germplasm was developed based on interspecific crosses that will allow for the future characterization of modifier genes that interact with the microfissuring gene (CWP) to promote or inhibit fruit cracking. One of the major accomplishments of the joint project was the integrated transcriptomic and proteomic analysis of the fruit cuticle and underlying tissues which allows for the identification of the pericarp cell layers responsible for the extracellular, cuticle-localized protein component. The results of the project have expanded our understanding of tomato fruit cuticle development and its genetic control. In addition, germplasm developed will be useful in developing tomato varieties resistant to cracking, on the one hand, and varieties useful for the dehydration industry on the other.

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