Um die anderen Arten von Veröffentlichungen zu diesem Thema anzuzeigen, folgen Sie diesem Link: Trial state.
Dissertationen zum Thema „Trial state“
Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an
Machen Sie sich mit Top-50 Dissertationen für die Forschung zum Thema "Trial state" bekannt.
Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.
Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.
Sehen Sie die Dissertationen für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.
1
Spaid, Mark Lugg Elizabeth T. „The Scopes trial and creation thought since 1925“. Normal, Ill. Illinois State University, 1999. http://wwwlib.umi.com/cr/ilstu/fullcit?p9927777.
Der volle Inhalt der QuelleAnnotation:
Thesis (Ph. D.)--Illinois State University, 1999.Title from title page screen, viewed July 20, 2006. Dissertation Committee: Elizabeth Lugg (chair), Dianne Ashby, Amee Adkins, Andrew Lugg. Includes bibliographical references (leaves 236-245) and abstract. Also available in print.
2
Seretny, Michael Lee. „Field trial with the Ball State diagnostic inventory based on the Feighner criteria“. Virtual Press, 1988. http://liblink.bsu.edu/uhtbin/catkey/560297.
Der volle Inhalt der QuelleAnnotation:
This study examined the Ball State Diagnostic Inventory. First, the construct validity of the measure and the 14 corresponding psychiatric diagnoses was considered. Secondarily, the investigation considered the psychiatric epidemiology of a college-age population.A review of the literature was presented with an emphasis on psychiatric syndromes, the Neo-Kraepelinian tradition, and the development of empirically based diagnostic criteria. The construction of the Ball State Diagnostic Inventory was placed in the historical context of the assessment of empirically based descriptive diagnostic criteria.One thousand and twenty-two undergraduate and graduate students from four U.S. universities volunteered to complete the Ball State Diagnostic Inventory. Participants were screened for prior psychiatric treatment or a course of psychotrophic medication. The mean chronological age of the subjects was 20.6 years (SD = 1.25) with a range of 18 to 28. The Ball State Diagnostic Inventory is a 218-item measure of adult psychopathology as reflected in the diagnostic criteria of the Diagnostic Inventory Schedule.The results showed the epidemiological point prevalence rates for this college age sample to correspond to other estimates. The 14-factor solution provided evidence of grouping of symptoms into traditionally defined diagnostic categories. Moreover, derived factors were similar to previous factor analytical studies with major psychiatric syndromes.The results were discussed in terms of their support for the utility of empirically based diagnostic criteria. Further investigations with the Ball State diagnostic Inventory were explored.Department of Educational Psychology
3
Stewart, Destin Nicole. „Juror Perceptions in a Rape Trial: Examining the complainant's ingestion of chemical substances prior to sexual assault“. MSSTATE, 2007. http://sun.library.msstate.edu/ETD-db/theses/available/etd-06262007-145952/.
Der volle Inhalt der QuelleAnnotation:
Despite the high incidence of rape in the United States, there are comparatively low rates of reports, arrests, and convictions. More research is needed to examine the factors that influence trial decisions for rape cases. This study examined the impact of a rape complainant?s willingness to ingest a chemical substance (willing or unwilling) and the type of ingested substance (alcohol, GHB, or marijuana) on the decisions of 229 mock jurors. Overall, jurors were biased by the complainant?s use of substances, the complainant?s choice about using, and by rape myths. The complainant?s use of alcohol, regardless of the willingness to use, led to the highest guilt ratings for the defendant. Complainants who willingly ingested a substance were viewed as less credible and more to blame for the rape, compared to those who unwillingly used a substance. The complainant was perceived as the most credible when she unwillingly ingested GHB or marijuana.
4
Stevenson, Hayley Diana. „First year growth response to mulching with on-farm wastes in an oak-pine-soybean agroforestry trial“. NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-03252009-104003/.
Der volle Inhalt der QuelleAnnotation:
Alley cropping may prove useful in the southeast U.S., providing multiple products and income streams, as well as affording sustainable land use alternatives to conventional farming and forest planting. Such systems in this region are of particular interest because they can help in soil conservation and nutrient retention and aid in sustaining and improving valued but degraded farmland. In the current study triple row single-species strips of loblolly pine (Pinus taeda), longleaf pine (Pinus palustris) and cherrybark oak (Quercus pagoda) were planted as 1-year-old seedlings separated by 12 or 24 m wide areas of soybean in spring 2007. Select individual tree seedlings of each species were treated with on-farm wastes, used as mulch in a circular area around each stem. These waste/mulches were hog bedding (corn stover + hog waste removed from swine houses), old hay (year-old rolled/slightly spoiled bermudagrass hay - Cynodon dactylon) and black plastic bedding film. After the first season of growth with the applied mulches, tree seedling growth rates were higher for cherrybark oak and longleaf pine seedlings mulched with old hay applied at 7.5 cm deep in 30 cm radius around each seedling. Other mulches had varying effects on soil conditions, but no significant impact on tree growth as compared to the untreated control seedlings. These first-year findings suggest that mulching with specific on-farm wastes may be a valuable management tool in temperate alley cropping systems. Longer term tree growth in this system and with regard to these initial mulching treatments will be studied.
5
Cox-Maksimov, Desiree. „The making of the clinical trial in Britain, 1910-1945 : expertise, the state and the public“. Thesis, University of Cambridge, 1997. https://www.repository.cam.ac.uk/handle/1810/272692.
Der volle Inhalt der Quelle
6
Schlee, Winfried. „Single-trial neuromagnetic analysis of auditory steady state responses and its application for the studies of chronic tinnitus“. [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-44631.
Der volle Inhalt der Quelle
7
Parker, Shaunta Shanell. „A Geographic Information System (GIS) Analysis of Cancer Clinical Trial Locations in the State of Georgia by Major Cancer Type“. Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/iph_theses/21.
Der volle Inhalt der QuelleAnnotation:
Improving cancer care through clinical research is a major public health issue. However, in Georgia, the exact number of cancer clinical trials is unknown, indicating the need for baseline data regarding cancer clinical trial locations and cancer burden. This study provides the first statewide analysis of cancer clinical trial locations using Geographic Information Systems (GIS). This study examines cancer clinical trial locations by county, according to incidence rates, racial patterns and mortality rates of the four major cancer types: breast, colorectal, lung, and prostate. Findings from this study suggest that metro-Atlanta counties have higher densities of cancer clinical trials. This study also found that there were little or no cancer clinical trials available in counties with the highest rates of overall incidence, African American incidence and overall mortality. This research demonstrates the need to increase availability of cancer clinical trials in counties with the highest cancer burden.
8
McKee, Justin. „A phase II randomised controlled trial of amiloride as a neuroprotective treatment in optic neuritis : studying in vivo neurodegeneration, neuroprotection and cortical plasticity after an inflammatory insult to the visual system“. Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:824ca36c-68ed-4b0c-90dc-925941ce9450.
Der volle Inhalt der QuelleAnnotation:
Basic science and early clinical trial evidence suggest the safe diuretic drug amiloride, may exert a neuroprotective effect in multiple sclerosis (MS) through blockade of the acid sensing ion channel. Neuroprotective treatments are a key unmet need in multiple sclerosis. Optic neuritis (ON) is a discrete CNS inflammatory event leading to neuro-axonal injury in the optic nerve and retina. The optic nerve is part of the visual system, one of the most functionally and structurally eloquent systems in the central nervous system, which affords a number of unique modalities to assess neurodegeneration and neuroprotection. The visual system can be classified into two parts, the anterior and posterior visual systems, which are defined by the lateral geniculate nucleus, where the two components synapse. The extent of neurodegeneration following ON in the anterior visual system can be imaged in vivo through scanning laser polarimetry (GDx) and optical coherence tomography (OCT). The posterior visual system can be imaged by quantitative and functional magnetic resonance imaging (MRI) of the brain, giving insights into white matter structural integrity and cortical plasticity over time. Combining these modalities in a longitudinal study, allows assessment of the impact of neurodegeneration in the anterior visual system on neurodegeneration downstream in the posterior visual system and on changes in functional connectivity over time in the visual cortex. Furthermore, in the clinical trial setting the neuroprotective effect of any intervention both on direct anterior neurodegeneration and downstream processes can be assessed. The functional relevance of changes in all of these biomarkers can be tested through a number of visual measures, including low contrast visual acuity. In MS, the contribution of transsynaptic neurodegeneration to the global neuronal loss experienced by patients is an area of incomplete understanding. In addition, the role of the visual cortex, through neuroplasticity, in aiding visual recovery from optic neuritis, is unclear. To address these issues, this thesis reports the results of the first clinical trial of amiloride in ON, and shows that despite the pre- and early clinical evidence of neuroprotection of amiloride, no neuroprotective benefit was found. It goes on to explore reasons for this lack of effect including the finding of early retinal neurodegeneration in ON, and the need for early recruitment windows in the future. From there, it makes a detailed assessment of the longitudinal changes in retinal OCT for 12 months following ON, including a novel finding of the temporal evolution of inner nuclear layer swelling, previously reported only cross-sectionally. Next, for the first time macular retinal neurodegeneration is shown to influence diffusion tensor MRI derived measures of white matter integrity in the optic radiations, indicating transsynaptic neurodegeneration. Finally, longitudinal changes in resting state functional connectivity following ON are found in the visual system for the first time. The interaction between this cortical functional, retinal neurodegeneration and visual recovery is probed.
9
Roll, Brooks Benjamin. „The effect of the provision of certain treatment programs on length of stay for 1370 commitments“. CSUSB ScholarWorks, 1993. https://scholarworks.lib.csusb.edu/etd-project/683.
Der volle Inhalt der Quelle
10
Curtis, Shawn D. „Cultural influence on the assessment of adjudicative competency: A grounded theory“. Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1569868152642414.
Der volle Inhalt der Quelle
11
Potter, Clare Louise. „Analysis of multidimensional state anxiety in horse trials“. Thesis, Liverpool John Moores University, 1996. http://researchonline.ljmu.ac.uk/5569/.
Der volle Inhalt der QuelleAnnotation:
The analysis of competitive state anxiety and its effect on sports performance has been undertaken by many researchers (Karteroliotis & Gill, 1987; Martens, Vealey, Burton, 1990; Jones, Swain & Hardy, 1993). This thesis focused on multidimensional competitive state anxiety and performance within the context of British Horse Society (BHS) one day horse trials. Initially, subjects (n=105) completed the Riders' Perceptions Questionnaire which was devised by the author to assess the nature of the interaction between the rider and horse during performance from the rider's perspective. Initial support for the rider and horse interaction was obtained and it was suggested that the rider's perceptions of the horse's performance must be taken into account when examining the anxiety experienced by the rider. Analysis of anxiety incorporated the Competitive State Anxiety Inventory - 2 (CSAT-2; Martens et al., 1990). Relationships between multidimensional anxiety, skill level, actual performance and perceived success were assessed. The results supported the view of multidimensional anxiety with psychological, physiological and behavioural components that change differently throughout the competition (Karteroliotis & Gill, 1987; Jones & Cale, 1989; Martens et al., 1990). Skill level was found to affect the level of anxiety experienced. Novice riders exhibited higher levels of cognitive and somatic anxiety and lower levels of self-confidence than Intermediate or Advanced riders. The effect of skill level in subsequent studies was similar in trend but the results were not significant. Within group variability was high, thus future assessment should assess anxiety levels utilising a more sensitive measure of skill level. Advanced riders were also found to perceive cognitive and somatic anxiety and self-confidence as more facilitative to performance than Intermediate or Novice riders. The assessment of the direction dimension of anxiety was particularly useful for the development of stress management programmes (Maynard, Hemmings & Warwick- Evans, 1995) and hence for the three collective case studies incorporated in the final stage of this thesis. The results provided evidence to support the current multidimensional anxiety theory within the sport of horse trials. Antecedents and causal attributions related to anxiety were measured. Perceived readiness, self-confidence and personal control were key factors affecting the performance and combating the negative effects of anxiety. Perceived readiness predicted performance. Further analysis of antecedents more specific to horse trials may help identify predictors of CSAI-2 components. Perceived success was associated with increases in self-confidence and was a significant predictor of performance in the next phase of the horse trial. Future research is encouraged into anxiety between phases of a competition to assess the effect of perceived success on future anxiety levels and performance more thoroughly. The final aim in this thesis was to assess the effectiveness of stress management intervention programmes via three collective case studies. The application of a stress management intervention programme (SMIP) was undertaken for each case study. Case study one is reported in detail whereas case studies two and three are summarised. Inter-case study comparisons were undertaken to assess the effectiveness of the SMIP. The SMIP's were effective in developing the rider's awareness of their psychological state, increasing self-confidence and enabling riders to employ coping skills successfully during a performance. Performance improvements occurred for each subject which also corresponded with an increased level of perceived success for each subject. The three collective case studies provided initial support for the usage of SMIP's for horse trials riders and hence supported the final aim in this thesis. The research has identified competitive state anxiety within horse trials in accordance with other sports (Martens et al., 1990). It is anticipated that the information will be used to aid riding instructors understand and predict the detrimental effects of anxiety for riders. The successful usage of SMIP techniques will provide valuable assistance for riders, coaches and BHS horse trials team selectors wishing to use stress management techniques for horse trials competition.
12
Rae, Jonathan. „Tribe and state : management of Syrian steppe“. Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323748.
Der volle Inhalt der Quelle
13
Zamani, Masoud. „Detention without trial : historical evolution, states' authority and international law“. Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28202/.
Der volle Inhalt der QuelleAnnotation:
In the wake of the US detention policy in the aftermath of the 9/11 attacks, the practice of detention without trial has gained a degree of attention unparalleled in the history of common law tradition. Legal analyses of all kinds have ensued, and countless policy plans and guidelines have been created. Yet, despite the pedigree of detention without trial, the historical dimension to the practice of detention without trial has not been invested with the scrutiny that it deserves. Drawing on the history of detention without trial in Britain, this research seeks to draw a roadmap for the evolving features of detention without trial. It will be argued that it is by virtue of this historical understanding that we can make sense of the modern laws governing the practice of detention without trial and its associated features.
14
Callahan, Joshua. „Erosion and Trail Building: A Case Study of the East Tennessee State University Trail System“. Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1952.
Der volle Inhalt der QuelleAnnotation:
Natural and accelerated erosion from trail users affects the sustainability of trail systems. Designing and building sustainable trail systems will greatly decrease the effect that erosion has on a trail. Trails that allow multiple types of users, such as hiking and mountain biking, must be able to sustain both groups. At East Tennessee State University the trail system was originally designed for hiking. Mountain bikers have become the main user group on the trail system leading to erosion problems on certain areas of the trail due to trail design flaws. The study seeks to identify the problem areas of trail and make recommendations towards correcting the trail in order for the trail system to adequately sustain both hikers and mountain bikers on the East Tennessee State University trail system.
15
Ustad, Karen L. (Karen Lee). „Standardization of the Assessment of Competency to Stand Trial“. Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc278831/.
Der volle Inhalt der QuelleAnnotation:
Evaluations of the Georgia Court Competency Test - Mississippi Version Revised (GCCT-MSH) and the Competency Screening Test (CST) have supported their use with pretrial defendants. The present study evaluated the efficacy of the measures with an inpatient population. Both measures were factor analyzed in an attempt to replicate; previously identified factor structures. Neither factor structure was replicated however, a distinct factor structure was identified for the GCCT-MSH. In addition, the relationship between sociodemographic variables, clinical variables, current symptomatology, and competency status were evaluated using discriminant functions analyses. The results suggest that the best predictors of incompetency in this sample are a diagnosis of a psychotic disorder or a non-psychotic affective disorder and a low measured IQ. Current symptomatology, as measured by the SCL-90-R, was not an effective predictor of competency status in this sample.
16
Draper, Timothy Dean. „An awakening and a nightmare : the diverse meanings of the Chicago conspiracy trial“. Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/460295.
Der volle Inhalt der QuelleAnnotation:
This is a study of the Chicago Conspiracy trial of 1969-1970, where eight radical leaders were tried in connection to the riots during the 1968 Democratic National Convention in Chicago, Illinois. The purpose of this thesis is to explore the meanings of the trial to American society in 1970 and from today's historical vantage point. Differing from first-hand accounts of the trial in the early 1970s, this study examines the different public perspectives of the trial through the use of such primary sources as underground newspapers, the defendants' writings, and appeals documents. Particular attention is devoted to the interpersonal relationships between the leading participants of the trial (the judge, attorneys, defendants, jurors, journalists, and spectators).The thesis is organized to highlight the major issues and controversies of the trial, while still addressing the personalities involved in the case. The context of the trial in an era of active American radicalism is examined both before and after the case was tried. An entire chapter is devoted to examining the diverse participants in the trial and the different roles they played in the event. Since the trial was so controversial because of legal issues and the conduct of the courtroom participants, a chapter has been devoted to both of these areas. Paticular attention is paid to events precipitating the prosecution of the eight radicals, including the Chicago Convention disorders and the federal grand jury that handed down the indictments. This organization lays a foundation for exploring the contemporary and historical significances of the trial in the conclusion of the study.
17
Kocher, T., B. Holtfreter, A. Petersmann, P. Eickholz, T. Hoffmann, D. Kaner, T. S. Kim et al. „Effect of Periodontal Treatment on HbA1c among Patients with Prediabetes“. Sage, 2019. https://tud.qucosa.de/id/qucosa%3A35798.
Der volle Inhalt der QuelleAnnotation:
Evidence is limited regarding whether periodontal treatment improves hemoglobin A1c (HbA1c) among people with prediabetes and periodontal disease, and it is unknown whether improvement of metabolic status persists >3 mo. In an exploratory post hoc analysis of the multicenter randomized controlled trial “Antibiotika und Parodontitis” (Antibiotics and Periodontitis)—a prospective, stratified, double-blind study—we assessed whether nonsurgical periodontal treatment with or without an adjunctive systemic antibiotic treatment affects HbA1c and high-sensitivity C-reactive protein (hsCRP) levels among periodontitis patients with normal HbA1c (≤5.7%, n = 218), prediabetes (5.7% < HbA1c < 6.5%, n = 101), or unknown diabetes (HbA1c ≥ 6.5%, n = 8) over a period of 27.5 mo. Nonsurgical periodontal treatment reduced mean pocket probing depth by >1 mm in both groups. In the normal HbA1c group, HbA1c values remained unchanged at 5.0% (95% CI, 4.9% to 6.1%) during the observation period. Among periodontitis patients with prediabetes, HbA1c decreased from 5.9% (95% CI, 5.9% to 6.0%) to 5.4% (95% CI, 5.3% to 5.5%) at 15.5 mo and increased to 5.6% (95% CI, 5.4% to 5.7%) after 27.5 mo. At 27.5 mo, 46% of periodontitis patients with prediabetes had normal HbA1c levels, whereas 47.9% remained unchanged and 6.3% progressed to diabetes. Median hsCRP values were reduced in the normal HbA1c and prediabetes groups from 1.2 and 1.4 mg/L to 0.7 and 0.7 mg/L, respectively. Nonsurgical periodontal treatment may improve blood glucose values among periodontitis patients with prediabetes (ClinicalTrials.gov NCT00707369).
18
Greening, Megan. „Contextualizing the Law: Sentencing Decisions of Sexual Assault Cases of Dallas County, 1999-2005“. Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5461/.
Der volle Inhalt der QuelleAnnotation:
The incidence of sexual assault inundates the courts with many cases each year. Given the unique nature of the crime, judges and juries are faced with an array of different scenarios to which they are required to make fair, justifiable and consistent decisions. I examine child sexual assault cases of Dallas County 1999-2005, I look at both legal and extralegal factors including case characteristics, institutional characteristics and characteristics of the defendants and the victims. First, I examine the impact of the independent variables on sentence length using regression analysis to determine influences on sentencing for judges and juries. Second, I examine the same factors using Probit analysis to determine which characteristics make a life sentence more probable for those decision-makers.
19
Ahamed, Farid Uddin. „Ethnicity and environment : 'tribal culture' and the state in Bangladesh“. Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446502/.
Der volle Inhalt der QuelleAnnotation:
This thesis investigates the current predicament of the people of Chittagong Hill Tracts (CHT) in Bangladesh, a population with significant cultural differentiation from the mainstream Bengali population. Dealing with the issues of their survival in the forest and their quest for identity, the research explores how their ethnicity and environment are intertwined. This is examined in the context of state policies towards non-Bengali ethnic minorities in the CHT. The study identifies sources of diversity at the micro level and the forces that create conditions for 'unity in diversity' at the macro level. One is the assertion of 'self-image' on the basis of cultural polarity within the confines of a multi-ethnic locality. The other is the assertion of 'collective image' as unifying forces stemming from the notion of shared deprivation and marginalisation generated by conditions of the State and State institutions. This ethnographic study is based on two years fieldwork between January 1999 and December 2000 among three ethnic groups, Marma, Bawm and Tanchanga in Banderban district of southern CHT. The thesis is divided into three main parts. Part one deals with research context, the historical development in CHT and the main theoretical issues concerning the relationships between ethnicity, social movement and indigenous land rights. The second part looks at local perceptions of settlement, locality and village organisation and at the dimensions of linguistic identity at both group and collective levels. The third part examines broader issues, events and processes concerning ethnic mobilisation around the traditional land use system, jhum, and the politics of khas land, based on case materials of how jhum lands are leased out to Bengalis. This is followed by analysis of local electoral processes and a concluding discussion of 'ethnic mobilisation', 'multi-ethnicity', and 'social movements'. The study promotes a deeper understanding of the multi-ethnic nature of the Bangladeshi State and provides a more balanced assessment of the relationship between ethnicity, environment, development and the state. It also contributes to the wider anthropology of forest-dwelling peoples of South Asia. It challenges the political use of environmentalism and anthropological knowledge in national and regional disputes over the control and use of natural resources.
20
Bueno, Kim Amaral. „O Processo, em Kafka e Welles : exceção e inação“. reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/33331.
Der volle Inhalt der QuelleAnnotation:
A análise comparativa entre o romance de Franz Kafka, O processo, e o filme homônimo de Orson Welles pretende compreender de que maneira a obra cinematográfica transcria o universo kafkiano, levando à tela cinematográfica o tempo, o espaço e o protagonista, a partir do hipotexto literário. As estratégias narrativas empregadas na produção da película problematizam a posição do narrador, onisciente no romance, mas que, no filme, salvo as evidentes diferenças narratológicas inerentes aos códigos, é produzido através de um “jogo de vozes”, partindo da parábola “Diante da Lei”, utilizada no incipit fílmico. O tempo e o espaço são configurados mantendo os traços “expressionistas” de Kafka, produzindo zonas de indeterminação temporais e topológicas que corroboram a inação do protagonista. O conceito de “estado de exceção”, esboçado por Giorgio Agamben, permite pensar que a origem do processo movido contra Josef K., de desconhecidas motivações, reside num poder de domínio e controle que antecede a própria lei. A aproximação do protagonista de Kafka e de Welles à figura do homo sacer é possível tanto pelo estatuto da ação que ele exerce em função da necessidade de defesa (o que caracteriza a sua inação, uma vez que não há “progressão”, a despeito das suas tentativas de produzir uma primeira petição de defesa), quanto das “deformidades” que o caracterizam, incorporando-o ao bando das personagens “monstruosamente” híbridas de Kafka. Porém, a “deformidade” que marca K. e o exclui da comunidade regida pelo ordenamento legal não está aparente, mas age biologicamente, estabelecendo um secreto mecanismo de controle cujo poder de decisão age sobre a orgânica morte, a extirpação de uma vida simplesmente “matável e insacrificável”.The comparative analysis between the novel of Franz Kafka, The Trial, and the homonym movie of Orson Welles intends to understand how the cinematographic workmanship used to transcribe the kafkian universe, taking to the cinematographic screen the time, the space and the protagonist from literary hipotext. The narrative strategies used in the production of the film problematize the position of the narrator, omniscient in the romance, but that, in the film (except for the evident narratological differences inherent to the codes), it is produced through a “game of voices”, coming from the parabola “Before the Law”, used in the filmic incipit. The time and the space are configured keeping “the expressionists” traces of Kafka, producing secular and topological zones of indetermination that corroborate the inaction of the protagonist. The concept of “exception state”, sketched for Giorgio Agamben, allows us to think that the origin of the process moved against Josef K, of unknown motivations, inhabits in a power of domain and control that precedes the proper law. The approach of the protagonist of Kafka and Welles to the figure of homo sacer is possible as much for the statute of the action that it exerts in function of the defense necessity (which characterizes its inaction, a time that does not have “progression”, in the spite of its attempts to produce a first petition of defense), how much of the “deformities” that characterize it, incorporating it to the flock of the “monstrously” hybrid personages “of Kafka. However, the “deformity” that marks K. and excludes it from the community conducted for the legal order is not apparent, but it acts biologically, establishing a private mechanism of control which power of decision falls again on the organic death, the extirpation of a simply “killable and unsacrifiable” life.
21
Netopil, Jan. „Analýza řadicího mechanizmu traktoru“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-445156.
Der volle Inhalt der QuelleAnnotation:
The thesis focuses on the shifting mechanisms of manually shifted tractor transmissions. It provides a comprehensive overview of all significant structural nodes of the shift mechanism with an analysis of the influence of the structure on the resulting intensity of a force required for shifting. The main aim of this thesis is the design and validation of experimental equipment for measuring the force effects of the shift mechanism of a mass-produced tractor in actual operation. The design of the experimental equipment is based on a study of the used measuring technique and similar experimental equipment. The final structure is selected based on selection by the method of weighted values, taking into consideration the requirements of the structure. A functional measuring chain is designed and formed for the realization of the measurement. To evaluate the data from the technical experiment, a multibody model of the designed experimental device is created in the MSC Adams View software, through which the real parameters of the shift mechanism are obtained from the measured values. The designed experimental equipment brings the possibility of complete analysis and subsequent optimization of the tractor's shift mechanism
22
Malone, Paul Matthew. „Starring Joseph K, four stage adaptations of Franz Kafka's novel The trial“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25107.pdf.
Der volle Inhalt der Quelle
23
Chan, Wing-shuen Jacqueline, und 陳永璇. „Characteristics of sponsored trials registered in the United States National Library of Medicine Clinical Trials Register“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B39723926.
Der volle Inhalt der Quelle
24
Dexter, Hedy Red. „In search of the fair jury : does extended voir dire remedy the effects of pretrial publicity?“ FIU Digital Commons, 1990. http://digitalcommons.fiu.edu/etd/2787.
Der volle Inhalt der QuelleAnnotation:
The present study asked two important questions: Does prejudicial pretrial publicity produce bias which may impair juror objectivity and, if it does, can voir dire remedy its untoward effects? Subjects were 68 college undergraduates whose political attitudes had been assessed and who had or had not read case-specific pretrial publicity one week before viewing a murder trial. Trial proceedings took place at the University of Miami law school. Voir dire, trial viewing, and deliberations were conducted in UM's moot courtroom. As predicted, analyses revealed main effects for both voir dire and pretrial publicity such that pretrial publicity increased conviction rate and the extended voir dire decreased conviction rate, but the extended voir dire failed to reduce the specific prejudicial effect of pretrial publicity. These findings suggest that prejudgment of a general nature (e.g., confusion about legal concepts) may be neutralized by an extended voir dire but that prejudice specifically created by exposure to inflammatory news stories is not offset by an extended voir dire format. There is reason to believe, however, that with more time spent explaining case facts and with greater attention to individual jurors, voir dire could eliminate even the specific prejudice created by pretrial publicity.
25
Rogers, Jane. „The Hinchingbrooke Third Stage Trial : what lessons can be drawn from this trial about the process and outcomes of midwifery practitioner research?“ Thesis, London South Bank University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428062.
Der volle Inhalt der Quelle
26
Xu, Jiajing, und 徐佳静. „Two-stage adaptive designs in early phase clinical trials“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/202252.
Der volle Inhalt der QuelleAnnotation:
The primary goal of clinical trials is to collect enough scientific evidence for a new intervention. Despite the widespread use of equal randomization in clinical trials, response-adaptive randomization has attracted considerable interest in terms of ethical concerns. In this thesis, delayed response problems and innovative designs for cytostatic agents in oncology clinical trials are studied.
There is typically a prerun of equal randomization before the implementation of response-adaptive randomization, while it is often not clear how many subjects are needed in this prephase, and in practice an arbitrary number of patients are allocated in this equal randomization stage. In addition, real-time response-adaptive randomization often requires patient response to be immediately available after the treatment, while clinical response, such as tumor shrinkage, may take a relatively long period of time to exhibit. In the first part of the thesis, a nonparametric fractional model and a parametric optimal allocation scheme are developed to tackle the common problem caused by delayed response. In addition, a two-stage procedure to achieve a balance between power and the number of responders is investigated, which is equipped with a likelihood ratio test before skewing the allocation probability toward a better treatment. The operating characteristics of the two-stage designs are evaluated through extensive simulation studies and an HIV clinical trial is used for illustration. Numerical results show that the proposed method satisfactorily resolves the issues involved in response-adaptive randomization and delayed response.
In phase I clinical trials with cytostatic agents, toxicity endpoints, as well as efficacy effects, should be taken into consideration for identifying the optimal biological dose (OBD). In the second part of the thesis, a two-stage Bayesian mixture modeling approach is developed, which first locates the maximum tolerated dose (MTD) through a mixture of parametric and nonparametric models, and then determines the most efficacious dose using Bayesian adaptive randomization among multiple candidate models. In the first stage searching for the MTD, a beta-binomial model in conjunction with a probit model as a mixture modeling approach is studied, and decisions are made based on the model that better fits the toxicity data. The model fitting adequacy is measured by the deviance information criterion and the posterior model probability. In the second stage searching for the OBD, the assumption that efficacy monotonically increases with the dose is abandoned and, instead, all the possibilities that each dose could have the highest efficacy effect are enumerated so that the dose-efficacy curve can be increasing, decreasing, or umbrella-shape. Simulation studies show the advantages of the proposed mixture modeling approach for pinpointing the MTD and OBD, and demonstrate its satisfactory performance with cytostatic agents.published_or_final_version
Statistics and Actuarial Science
Master
Master of Philosophy
27
Gandhi, Ajay. „State (under)development, transnational activism, and tribal resistance in India's Narmada valley“. Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33895.
Der volle Inhalt der QuelleAnnotation:
This thesis examines how the Narmada damming project in India is constituted and contested by the state, affected tribal peoples ( adivasis), and a transnational advocacy network led by the Narmada Bachao Andolan (Save the Narmada Movement). Based on ethnographic fieldwork, and employing critical anthropological perspectives on development and globalization, the power relations underlying dominance and resistance are mapped out. The conflicting discourses, strategies and practices of Narmada proponents and opponents are conceptualized within local, regional, national, and transnational sites and modalities. Further, the negotiation of state dominance and adivasi resistance is analyzed through contradictory practice and shifting political alignments. Lastly, this thesis delineates how the Narmada conflict is permeated by complex symbolic and moral mechanisms activated by both state authorities and activist resistors.
28
Carlyle, Greg A. „Postsecondary transitions of Mississippi Band of Choctaw Indians Tribal Scholarship Program students“. Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-11022007-162534.
Der volle Inhalt der Quelle
29
Chan, Wing-shuen Jacqueline. „Characteristics of sponsored trials registered in the United States National Library of Medicine Clinical Trials Register“. View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36887092.
Der volle Inhalt der Quelle
30
Latham, Evelyn Hartzell. „The electoral college system for the election of the President of the United States on trial“. CSUSB ScholarWorks, 2003. https://scholarworks.lib.csusb.edu/etd-project/2192.
Der volle Inhalt der QuelleAnnotation:
This thesis briefly reviews the content of Article II, section 1 of the Constitution which established the Electoral College (modified by Amendment XII), and the principel reform plans that have developed over the years. The reform efforts are examined, together with their possible effects on the entire political system.
31
Morgan, Steven A. „The Mini-Trial : a valuable alternative dispute resolution tool for the United States Navy“. Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1997. http://handle.dtic.mil/100.2/ADA340947.
Der volle Inhalt der QuelleAnnotation:
Thesis (M.S. in Management) Naval Postgraduate School, December 1997."December 1997." Thesis advisor(s): David V. Lamm, Mark W. Stone. Includes bibliographical reference (p. 127-131). Also available online.
32
Gray, Andrea Rebecca. „Supper on the Trail: How Food and Provisions Shaped Nineteenth-Century Westward Migration“. NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-05092008-134048/.
Der volle Inhalt der QuelleAnnotation:
Between the late 1830s and the 1860s, over 350,000 men, women, and children traveled overland along the Oregon and California Trails to the American West. Using primary sources including narratives, diaries, journals, reports, and letters, one discovers that obtaining food was perhaps the most critical concern for westward migrants. That overlanders and their animals had to eat is nothing new or alarming, but their need for food did carry many unexpected implications. Food connected migrants to the land, and in turn the land connected people to each other through competition over resources such as water, grass, and timber. Through their primary role as cooks, womenâs experiences of the trail centered around the preparation of food. Native Americans and white migrants interacted peaceably by sharing or trading food, while competition over natural resources at the same time strained relations and devastated many western tribes whose land was ravaged by the train of migrants. Food influenced the timing and routes of travel, the health and mood of travelers, and the economic and physical status of settlers upon arrival in the West. The overlandersâ need for nourishment serves as the framework for understanding how provisions helped determine the overall experience of westward travel and reveals that food shaped mid-nineteenth-century westward migration.
33
Li, Hoi-kwong. „Filing of complaints by the US Food and Drug Administration /“. View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35082471.
Der volle Inhalt der Quelle
34
Somel, Gozde. „Centralization And Opposition In Mongol And Ottoman State Formations“. Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609849/index.pdf.
Der volle Inhalt der QuelleAnnotation:
The Mongol and the Ottoman leadership structures emerged in milieus where identities were changeable, mobility was high and the alliances were shifting. Chinggis Khan arose to degree of Khanate of entire Mongolia from an extremely marginal position in tribal politics and his experiences in this process provided him an anti-tribal political vision. He at the very beginning of his career formed the nucleus of his political power by his relationships and entourages. Later, he reorganized the clans and tribes, which submitted their loyalty to him around those principal participants in his army of conquest. Osman Bey made successful conquests thanks to the advantageous geographical position of his principality, became famous in a short time and managed to attract various elements of complex social structure of the Byzantine frontiers to him. He did not involve in a harsh struggle for leadership. Instead of monopolization of power, he favored sharing of it with his companions in arms.
Mongols, after monopolizing power in the steppes devoted their energies to frontier conquests. However, during Chinggis Khan&rsquos reign, the Mongols saw the centre of the authority there. Their relation with the societies outside the Mongolia was indirect. Ottomans on the other hand, built up their administrative apparatus in the conquered territories. The Ottomans created a new bureaucratic group which did not have a power base besides the posts in Ottoman state and placed them to the centre of administration. Those posts did not have any hereditary dimension. The Mongols, contrary to the Ottomans, turned the state offices to hereditary posts and in time they began to distribute peoples, armies, lands and resources throughout the empire as appanages to state officers. Therefore, the Chinggisids created a new aristocracy who had the power in their hands to shake the centralist order of Chinggis Khan.
35
Björkquist, Cornelia. „States’ Possibilities to Guarantee Fair Trial Rights in the Context of Security Council Targeted Sanctions“. Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-69340.
Der volle Inhalt der Quelle
36
Lawrence, Greta. „The United States and the concentration camp trials at Dachau, 1945-1947“. Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/286027.
Der volle Inhalt der QuelleAnnotation:
After much debate during the war years over how best to respond to Nazi criminality, the United States embarked on an ambitious postwar trial program in occupied Germany, which consisted of three distinct trial sets: the International Military Trial at Nuremburg, the Nuremberg Military Tribunals, and military trials held at the former concentration camp at Dachau. Within the Dachau military tribunal programme, were the concentration camp trials in which personnel from the Dachau, Mauthausen, Buchenwald, Flossenbürg, and Dora-Mittelbau concentration camps were arraigned. These concentration camp trials at Dachau represented the principal attempt by the United States to punish Nazi crimes committed at the concentration camps liberated by the Americans. The prosecutors at Dachau tried 1,045 defendants accused of committing violations of the 'laws of war' as understood through 'customary' international and American military practice. The strain of using traditional military law to prosecute the unprecedented crimes in the Nazi concentration camps was exposed throughout the trials. To meet this challenge, the Dachau concentration camp courts included an inventive legal concept: the use of a 'criminal-conspiracy' charge-in effect arraigning defendants for participating the 'common design' of the concentration camp, 'a criminal organization'. American lawmakers had spent a good deal of time focused on the problem of how to begin the trials (What charges? What courts? Which defendants?) and very little time planning for the aftermath of the trials. Thus, by 1947 and 1948, in the face of growing tensions between the United States and the Soviet Union, the major problem with the Dachau trials was revealed -the lack of long term plans for the appellate process for those convicted. After two scandals that captured the press and the public's attention, the United States Congress held two official investigations of the entire Dachau tribunal programme. Although the resulting reviews, while critical of the Army's clemency process, were largely positive about the trials themselves, the Dachau trials faded from public memory.
37
Gomez, Peter L. „Enhancing FBI terrorism and homeland security information sharing with state, local and tribal agencies“. Thesis, Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/5159.
Der volle Inhalt der QuelleAnnotation:
CHDS State/LocalApproved for public release; distribution is unlimited
This thesis examines FBI terrorism and homeland security information sharing with state, local and tribal homeland security agencies mandated by presidents Bush and Obama, and the U.S. Congress. The thesis compares this "status quo" with three new proposed approaches that use technology and modify the FBI "routine use" exceptions to the Privacy Act to improve overall FBI information sharing. The thesis rates the following approaches: (1) "status quo," (2) new homeland security "routine use" exception, (3) Discoverability of Information and (4) XML Segregation of Information. All four options are analyzed using a two-phase analysis to determine their effectiveness and likelihood of successful implementation. The effectiveness is evaluated by judging the information shared, the privacy protected and the security of each approach. The likelihood of successful implementation is evaluated by judging the impact of FBI cultural resistance, fiscal performance, utilization of technology and training requirements. This thesis proposes the implementation of all three proposed approaches to enhance overall FBI terrorism and homeland security information sharing.
38
Davis, James Jordan. „Informal and Formal Legitimation of State-Sponsored Force in the Cherokee Trail of Tears“. The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306175761.
Der volle Inhalt der Quelle
39
Levy, Philip A. „Fellow travelers: Indians and Europeans together on the early American trail“. W&M ScholarWorks, 2001. https://scholarworks.wm.edu/etd/1539623383.
Der volle Inhalt der QuelleAnnotation:
The European exploration of America has traditionally conjured up images of Europeans intrepidly scanning horizons, meticulously detailing maps, and graciously offering curious natives access to God and goods. More than two decades of anthropological, historical, and ethnohistorical scholarship have tempered this heroic image and shown in great detail the complex and often contradictory role Indians played in this grand drama. Consequently, one can no longer picture colonial-era European explorers or travelers without also envisioning their Indian companions, both men and women, guiding the way, carrying the baggage, gathering the food, and providing needed information. This dissertation examines the character of the personal relationships that Indians and Europeans formed together while on North American expeditions of conquest, trade, and Christianizing between 1520 and 1800.;Travel entailed confrontations with the elements that could literally wipe out a party that made a wrong turn, ignored or misread the weather, or misjudged the current of a given rapid. Furthermore, poor provision planning or diplomatic bungling could also bring the grandest plans to grand disaster. But while battling the elements, Indian and European travel partners often battled each other. They played a subtle game of tug-of-war for control over the course, pace, and timing of travel. They fumed and connived over whose leadership, strategies, and values should hold sway. They wrestled over whose deities should be honored, and they derided each other's individual and collective abilities when one failed to live up to the other's visions of the ideal traveler. Tensions ranged from the subtlest forms of petty one-upmanship to physical coercion, and even occasional fisticuffs. It was the trail's defining conditions, its dangers, unfamiliarity, and isolation from comfortable and reassuring trappings of social prestige that exacerbated these tensions. The resulting contests reveal how different cultural meanings could swirl around trips and travel events often seen by historians as relatively straightforward moments in Europe's colonial expansion. They also demonstrate how individuals of different backgrounds constructed themselves and their fellow travelers while on the trail.
40
Bratton, D. J. „Design issues and extensions of multi-arm multi-stage clinical trials“. Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1459437/.
Der volle Inhalt der QuelleAnnotation:
The increasing cost of randomised controlled trials is hindering the rate at which new, effective therapies reach patients. To accelerate drug development, more efficient clinical trial designs are needed. One such design which has had success in speeding up the evaluation of therapies in cancer is the multi-arm multi-stage (MAMS) design. This particular design compares multiple new treatments against a control in a single trial, obviating the need for multiple two-arm studies, and ceases recruitment to poorly performing arms during the study. To further increase efficiency, interim assessments can be based on an intermediate outcome which is on the causal pathway to the primary outcome of the trial, thus allowing phases 2 and 3 of evaluation to be incorporated into a single, seamless design. The MAMS design was initially developed for trials in cancer where time to event outcomes are commonly used. To make it more widely applicable to other disease areas, we first extend the design to other types of outcome measure such as binary. The new designs are then applied to trials in tuberculosis --- a disease area with many new treatments currently in the clinical pipeline and which may therefore benefit from using more efficient trial designs. We then consider more general design issues such as familywise error rate and expected sample size and present calculations of both measures using simulation. Methods are developed for finding designs which have the desired overall operating characteristics and which are the most efficient under particular optimality criteria, known as admissible designs. Guidance is provided for choosing the number of stages and allocation ratio for a particular number of arms and we apply the methods developed in the thesis to existing and hypothetical MAMS trials. Throughout, Stata programs are created and updated to accommodate the use of the methods in practice.
41
Magirr, Dominic. „Design, conduct and analysis of multi-arm multi-stage clinical trials“. Thesis, Lancaster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664454.
Der volle Inhalt der QuelleAnnotation:
In this thesis, contributions are made towards improving the design, conduct and analysis of multi-arm multi-stage clinical trials. First, we generalize the Dunnett (1955) test to derive efficacy and futility boundaries for a multi-arm multi-stage clinical trial. We show the boundaries control the familywise error rate in the strong sense. The method is applicable for any number of treatment arms, number of stages and number of patients per treatment per stage. It can be used for a wide variety of boundary types or rules derived from a-spending functions. Additionally, we show how sample size can be computed under a least favourable configuration power requirement and derive formulae for expected sample sizes. Next, we describe a general method for finding a confidence region for a vector of K unknown parameters that is compatible with the decisions of a two-stage closed testing procedure in an adaptive experiment. The closed test procedure is characterized by the fact that rejection or nonrejection of a null hypothesis may depend on the decisions for other hypotheses and the compatible confidence region will, in general, have a complex, nonrectangular shape. We find the smallest Cartesian product of simultaneous confidence intervals containing the region and provide computational shortcuts for calculating the lower bounds for parameters corresponding to the rejected null hypotheses. We illustrate the methodology with a detailed example of an adaptive Phase II/III clinical trial. Finally, using the combination test principle and the conditional error principle, we develop flexible sequential designs for multi-arm clinical trials with early stopping for efficacy and futility. Such designs have the flexibility to cope with a large range of exigencies that may occur in practice. They also have the advantage that test decisions are based on sufficient statistics if the trial proceeds as originally planned.
42
Zakaria, John Lat. „A review of Tribal Armed Conflict Resolution in selected counties in Lakes State, South Sudan“. Thesis, University of Fort Hare, 2013. http://hdl.handle.net/10353/d1015247.
Der volle Inhalt der QuelleAnnotation:
This mini-dissertation, aims to review tribal armed conflict resolution in selected Counties in Lakes State, South Sudan. The objectives of the study were to find out the consequences of the tribal armed conflicts on governance and service delivery and strategies to mitigate peace and tribal armed conflict resolution in order to enable development in the selected counties of Lakes state. Quantitative and qualitative data was collected from a sample of three hundred and ten (310) respondents who included the County Commissioners, Judges and Magistrates, Law enforcement officers, local government officers and traditional leaders through questionnaires and interviews. The study sought to review the effects of tribal armed conflicts on service delivery in the selected communities. It further examined conflict resolutions mechanisms and strategies that have been used by various actors and stakeholder to ameliorate tribal armed conflict in Lakes State, South Sudan. The results of the study showed that ethnicity in conflicts in South Sudan has played a significant role and has posed many challenges to scholars, political leaders, appointed public officials and communities alike. Some of the challenges include; tribalism, ethnic conflicts, and struggle over scarce resources. This has often led to rampant underdevelopment, under-representation in governance; unemployment and poverty, among administrative perils and dysfunctions that have subsequently been major drivers of tribal armed conflicts. Many youth who are unemployed are often involved in cattle raiding, hence revenge attacks often lead to frequent tribal armed conflicts. The study recommends that effective and sustainable peace building can be achieved through empowerment of the communities and use of traditional strategies in tribal armed conflict resolution in Lakes State. This is because external players often attempt to engage in peace building activities without seeking sustainable solutions at the grassroots level. Very often conflict resolution has been the preserve of NGOs and diplomats, who have no intimate acquaintance with local contexts. The study suggests that provision of services to the people through sustainable development of the rural areas and through the creation of alternative forms of livelihood, such as jobs, has to engage with and include the youth in economic development, so that tribal armed conflicts are ameliorated.
43
Jayaraj, Ramamoorthi, und Jayaraj@menzies edu au. „Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials“. RMIT University. Applied Science, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20081029.100156.
Der volle Inhalt der QuelleAnnotation:
The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans. The geographical range of these two parasite species (temperate and tropical respectively) ensures that infection can occur worldwide. Although anthelmintic treatment is effective against disease, emerging drug resistant strains leads to the development of a vaccine. However, despite several decades of research, there is no commercial vaccine available. The main challenge at present is to produce recombinant proteins in an immunologically active form using recombinant DNA technology. This is an essential step in Fasciola vaccine production. Cysteine proteases are probably the most important facilitators of virulence in flukes and are produced by all stages of the fluke life-cycle. Two classes of cysteine protease are found in the excretory and secretory material of liver flukes- these are cathepsin L and cathepsin B. As such, the major aims of this thesis were to investigate the expression and purification of Fasciola recombinant cysteine proteins, and characterisation by SDS-PAGE and immunoblotting using monoclonal and polyclonal antibodies. These studies demonstrate the production of functionally active cathepsin proteins in S. cerevisiae BJ3505 cells which will lead to vaccine candidate analysis. The second aim of this thesis was to determine the protective efficacy of stage specific target antigens against experimental infection. In addressing this issue, the protective efficacy of single and multivalent recombinant protein vaccinations of adult stage F. hepatica cathepsin L5, immature F. gigantica cathepsin L1g and juvenile F. hepatica cathepsin B were analysed in Sprague Dawley rats against F. hepatica infection. This study demonstrates that juvenile fluke target antigen-cathepsin B induces better immune protection than adult fluke antigen-cathepsin L5. Cocktails of juvenile and adult stage fluke recombinant proteins (cathepsin B and L5) elicited the highest protective immunity against experimental infection and this combination showed not only reduction in fluke recovery and size of flukes, but also marked diminution in the intensity of liver lesions in vaccinated rats. In order to assess the immunogenic property of an early infective stage fluke secreting cysteine protease as a vaccine candidate, DNA vaccination vectors encoding cathepsin B were analysed in BALB/c mice. In this study, the ability of four DNA vaccination strategies such as secretory, chemokine-activating, lymph node targeting vectors encoding cathepsin B were assessed by antibody titre, antibody avidity, western blotting and ELIPSOT assay. The results have further validated the immunoprophylactic potential of a cathepsin B vaccine against F. hepatica. In this study, we have expressed and attained high yields of F. gigantica cathepsin L1g from E. coli BL21, and compared this to a yeast-expressed system. This protease was over-expressed and formed insoluble inclusion bodies that were subsequently solubilised with urea or guanidine hydrochloride. In order to purify the urea-solubilised protein, step-wise urea gradient chromatography was used. For refolding of solubilised protein, a dilution and dialysis procedure was utilised. Proteolytic activity was confirmed by gelatin SDS-PAGE analysis. In conclusion, the determination of the immune potential of recombinant stage specific antigens allows the development of effective vaccines against Fasciola infection.
44
Clarkin, Thomas. „The new trail and the great society : federal Indian policy during the Kennedy-Johnson administration /“. Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.
Der volle Inhalt der Quelle
45
Roberts, S. K. P. „Prosecutorial discretion in the pre-trial criminal process : the Crown Prosecutor and Assistant United States Attorney compared“. Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367790.
Der volle Inhalt der Quelle
46
Halson, Shona L. „Performance, metabolic and hormonal alterations during overreaching“. Queensland University of Technology, 2003. http://eprints.qut.edu.au/15790/.
Der volle Inhalt der QuelleAnnotation:
Many athletes incorporate high training volumes and limited recovery periods into their training regimes. This may disrupt the fragile balance and the accumulation of exercise stress may exceed an athlete's finite capacity of resistance. A state of elevated fatigue, increased mood disturbance and decreased exercise performance can result. This is commonly known as overreaching and if increased training and limited recovery is continued, it is believed that the more serious state of overtraining may develop. This is relatively commonly experienced in athletes, however little scientific investigation has been conducted to determine the characteristics and underlying mechanisms. The overall aim of this thesis was to gain a greater understanding of the state of overreaching and to specifically provide new information on potential markers of this state as well as possible mechanisms. To study the cumulative effects of exercise stress and subsequent recovery on performance changes, fatigue indicators and possible mechanisms, the training of endurance cyclists was systematically controlled and monitored in two separate investigations. A number of variables were assessed including performance, physiological, biochemical, psychological, immunological and hormonal variables. In addition heart rate variability and serotonergic responsiveness were also assessed. Some of the more pertinent effects of overreaching included an increase in heart rate variability, a reduction in carbohydrate oxidation, an increase in serotonergic responsiveness and a reduction in stress hormone concentrations. These results suggest that autonomic imbalance in combination with decreased hormonal release appears to be related to the decline in performance and elevated fatigue apparent in overreached athletes. Additionally it also appears that alterations in the hypothalamic-pituitary adrenal axis may occur in overreached athletes.
47
Van, Pottelsberghe Bruno. „The efficiency of science and technology policies inside the triad“. Doctoral thesis, Universite Libre de Bruxelles, 1997. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212154.
Der volle Inhalt der Quelle
48
Heller, Gillis L. „Hepatic and renal impairment trials : FDA guidance and industry practice /“. Thesis, View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38030548.
Der volle Inhalt der Quelle
49
John, Paul. „Modelling Recreation Demand Using Choice Experiments : Using Swedish Snowmobilers Demand for Groomed trails“. Thesis, Högskolan Dalarna, Nationalekonomi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:du-4642.
Der volle Inhalt der QuelleAnnotation:
This paper is concerned with the use of the choice experiment method for modeling the demand for snowmobiling . The Choice Experiment includes five attributes, standard, composition, length, price day card and experience along trail. The paper estimates the snowmobile owners’ preferences and the most preferred attributes, including their will-ingness to pay for a daytrip on groomed snowmobile trail. The data consists of the an-swers from 479 registered snowmobile owners, who answered two hypothetical choice questions each. Estimating using the multinominal logit model, it is found that snow-mobilers on average are willing to pay 22.5 SEK for one day of snowmobiling on a trail with quality described as skidded every 14th day. Furthermore, it is found that the WTP increases with the quality of trail grooming. The result of this paper can be used as a yardstick for snowmobile clubs wanting to develop their trail net worth, organizations and companies developing snowmobiling as a recreational activities and marketers in-terested in marketing snowmobiling as recreational activities.
50
Arrieta, Caro José. „Rise and Fall of the Constitutional Right to a Jury Trial for Criminal Cases in the United States“. Pontificia Universidad Católica del Perú, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/115996.
Der volle Inhalt der QuelleAnnotation:
Since its appearance in Europe, the trial by jury had to travel a long path until it became the official procedure to try criminal cases in the United States. Although it was not really created with that specific purpose, over the years it experienced memorable moments in which it was granted with the prestige and value required to be inserted in the Constitution of that country, as a safeguard against the arbitrariness of the governmental power. Today, however, the great importance that it had in the past has significantly decreased. The needs and practices of a system with a particularly high rate of convictions have relegated and transformed it into a real endangered specie. The following article describes and explains its birth and rise, as well as its subsequent virtual disappearance due to the not so efficient as dangerous guilty pleas.Desde su aparición en Europa, el juicio por jurados tuvo que recorrer un largo camino para convertirse en el método oficial de juzgamiento de casos penales en los Estados Unidos. A pesar de que no fue creado exactamente con esa finalidad, tuvo varios momentos memorables durante su desarrollo que le otorgaron el prestigio y valor necesarios para insertarse en la Constitución de ese país como una garantía frente al abuso del poder. Hoy, sin embargo, la gran importancia que alguna vez tuvo ha quedado atrás. Las necesidades y prácticas propias de un sistema con una altísima tasa de condenas han terminado por relegarlo, convirtiéndolo en una verdadera especie en peligro de extinción. El siguiente artículo describe y explica el nacimiento y auge de los juicios por jurados para causas penales y su posterior virtual desaparición a manos de los no tan eficientes como peligrosos acuerdos negociados de condena.