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Thematische Bibliographien / Toxicity testing In vitro

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Zeitschriftenartikel
Dissertationen
Bücher
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Berichte der Organisationen

Auswahl der wissenschaftlichen Literatur zum Thema „Toxicity testing In vitro“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 30. Juli 2024

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Zeitschriftenartikel zum Thema "Toxicity testing In vitro"

1

Ciabattoni, G., P. Montuschi, D. Curró, and P. Preziosi. "In vitro testing for lung toxicity." Toxicology in Vitro 7, no. 5 (September 1993): 581–85. http://dx.doi.org/10.1016/0887-2333(93)90091-i.

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Flint, Oliver. "In Vitro Toxicity Testing: Redefining our Objectives." Alternatives to Laboratory Animals 20, no. 4 (October 1992): 571–74. http://dx.doi.org/10.1177/026119299202000411.

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Soldatow, Valerie Y., Edward L. LeCluyse, Linda G. Griffith, and Ivan Rusyn. "In vitro models for liver toxicity testing." Toxicol. Res. 2, no. 1 (2013): 23–39. http://dx.doi.org/10.1039/c2tx20051a.

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4

Lipman, Jack, Oliver Flint, June Bradlaw, John Frazier, Charlene McQueen, Carol Green, Daniel Acosta, et al. "Cell culture systems andin vitro toxicity testing." Cytotechnology 8, no. 2 (June 1992): 129–76. http://dx.doi.org/10.1007/bf02525495.

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5

DelRaso, N. J. "In vitro methodologies for enhanced toxicity testing." Toxicology Letters 68, no. 1-2 (May 1993): 91–99. http://dx.doi.org/10.1016/0378-4274(93)90122-e.

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Prieto, Pilar. "Barriers, Nephrotoxicology and Chronic Testing In Vitro." Alternatives to Laboratory Animals 30, no. 2_suppl (December 2002): 101–5. http://dx.doi.org/10.1177/026119290203002s15.

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In many organs of the human body, there are effective physiological barriers which contribute to regulation of the uptake, transport and secretion of endogenous and exogenous materials. ECVAM is involved in the development of several in vitro models for detecting damage to various barriers, including, the renal epithelium, the intestinal barrier, and the blood–brain barrier, after acute and chronic exposure to chemicals and products of various kinds. Long-term toxicity testing is an important issue in toxicology. At present, there are no generally accepted in vitro models available for replaci

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Flint, Oliver P. "In Vitro Toxicity Testing: Purpose, Validation and Strategy." Alternatives to Laboratory Animals 18, no. 1_part_1 (November 1990): 11–18. http://dx.doi.org/10.1177/026119299001800103.1.

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The fullest potential for in vitro evaluation of toxicity will be realised in the context of the process of assessing the risk of human toxicity. This article is an attempt to clarify what contributions can be made by in vitro tests and what types of in vitro test can best be used. In vitro tests are clarified according to the type of biological endpoint evaluated, first into tests for general (‘basal’) cytotoxicity and, secondly, into tests for differentiated cell function. The role of each type of test is analysed and it is suggested that tests for general cytotoxicity, as opposed to differe

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Vinken, M. "Liver-based in vitro models for toxicity testing." Toxicology Letters 295 (October 2018): S7. http://dx.doi.org/10.1016/j.toxlet.2018.06.029.

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Jennings, P. "Kidney-based in vitro models for toxicity testing." Toxicology Letters 295 (October 2018): S7—S8. http://dx.doi.org/10.1016/j.toxlet.2018.06.030.

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Constant, S. "Lung-based in vitro models for toxicity testing." Toxicology Letters 295 (October 2018): S8. http://dx.doi.org/10.1016/j.toxlet.2018.06.031.

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Dissertationen zum Thema "Toxicity testing In vitro"

1

Radburn-Smith, Marcus Alexander. "Novel in vitro models and methods for ocular toxicity testing." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443263.

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Yang, Jie. "Three dimensional perfused cell culture for in vitro toxicity testing." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:a72b7015-cc57-4bb8-904a-a5a88e2194f1.

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This study describes the development of a novel method of three dimensional perfused cell culture for in vitro toxicity testing. Multiple parallel perfused microbioreactors (TissueFlex<sup>TM</sup>) were adopted to provide a well-controlled cell culture environment. Alginate and collagen type I, commonly used as hydrogel scaffolds to support cell culture, were tested as the scaffolding materials for this application. Alginate supports cell proliferation, but does not support cell attachment. Collagen gel (type I), good for cell attachment but with poor mechanical strength, could be used at the

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Lestari, Fatma Safety Science Faculty of Science UNSW. "Development of in vitro toxicity methods for fire combustion products." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/24280.

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A large range of polymers are used in building and mass transport interiors which released more toxic products during combustion. This work explores the cytotoxicity of selected chemicals and smoke derived from materials combustion. A selection of polymers and fiberglass reinforced polymer (FRP) composites used in building and railway carriage interiors including: polyethylene (PE), polypropylene (PP), polycarbonate (PC), polymethyl methacrylate (PMMA), polyvinyl chloride (PVC), melamine plywood, and two FRPs were studied. A small scale laboratory fire test using a vertical tube furnace was de

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Lawrence, J. N. "Cryopreservation and toxicity studies with cultured rat and human hepatocytes." Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233123.

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Bruschi, Sam A. "Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems /." Title page, abstract and table of contents only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phb192.pdf.

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Yu, Lok Chiu. "Cellular metabolism in in vitro toxicity and toxicology studies." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/675.

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McKay, Gillian Claire. "Cryopreservation of hepatocyte monolayers : a potential in vitro model system for toxicity testing." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366885.

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Bakand, Shahnaz Safety Science Faculty of Science UNSW. "Development of in vitro methods for toxicity assessment of workplace air contaminants." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/24246.

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Exposure to air contaminants is significantly associated with both short-term and long-term health effects. However, the precise mechanisms that derive such effects are not always understood. While an extensive background database from in vivo toxicological studies have been developed, most toxicity data is from oral and dermal chemical exposures rather than inhalation exposure. There is a need to explore new alternative approaches to provide toxicity information particularly on this technically demanding area. This research explores the potential of in vitro methods for toxicity assessment of

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Pu, Yubing. "Toxicity assessment of engineered nanoparticles." Thesis, Troyes, 2017. http://www.theses.fr/2017TROY0001/document.

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L'objectif de cette thèse est d'améliorer la compréhension de la toxicité de diverses nanoparticules de synthèse (ENPs) pour l'homme et l'écosystème. Les travaux réalisés s’appuient sur la combinaison de données toxicologiques et d’un modèle environnemental - le modèle USEtox. En tant qu'élément important de l'évaluation de l'impact du cycle de vie, le facteur de caractérisation (CF) a été utilisé, dans ce travail, comme indicateur de toxicité pour l'homme et l'écosystème. Pour avoir accès aux courbes dose-réponse et à différentes données toxicologiques, des expériences in vitro ont été réalis

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Cadieux, Brigitte. "Development of a novel, rapid, in vitro assay for the detection of Clostridium botulinum neurotoxin type E." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32836.

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Botulism is a foodborne intoxication caused by ingestion of Clostridium botulinum neurotoxin (BoNT). Preliminary studies focussed on the production of polyclonal antisera against BoNT/E by immunizing a rabbit with botulinal toxoid type E. The antiserum was subsequently used to detect BoNT/E using the slot blot immunoassay where samples were applied to a slot blot filtration manifold and drawn by vacuum through a membrane. The membrane was then immunologically processed before chemiluminescent detection. However, the antisera lacked specificity and cross-reacted with closely related clostridia

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Bücher zum Thema "Toxicity testing In vitro"

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O’Hare, Sheila, and Chris K. Atterwill, eds. In Vitro Toxicity Testing Protocols. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0896032825.

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Sheila, O'Hare, and Atterwill C. K, eds. In vitro toxicity testing protocols. Totowa, N.J: Humana Press, 1995.

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M, Frazier John, ed. In vitro toxicity testing: Applications to safety evaluation. New York: Marcel Dekker, 1992.

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Evelyn, Tiffany-Castiglioni, ed. In vitro neurotoxicology: Principles and challenges. Totowa, N.J: Humana Press, 2004.

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M, Goldberg Alan, Principe Marilyn L, and Johns Hopkins Center for Alternatives to Animal Testing. Symposium., eds. In vitro toxicology: New directions. New York: Mary Ann Liebert, Inc., 1989.

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M, Goldberg Alan, and Principe Marilyn L, eds. In vitro toxicology: Mechanisms and new technology. New York: Mary Ann Liebert, Inc., 1991.

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M, Goldberg Alan, Principe Marilyn L, and Johns Hopkins Center for Alternatives to Animal Testing., eds. Progress in in vitro toxicology. New York: Mary Ann Liebert, Inc., Publishers, 1988.

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M, Goldberg Alan, Principe Marilyn L, and Johns Hopkins Center for Alternatives to Animal Testing. (6th : 1989 : Baltimore, Md.), eds. In vitro toxicology: New directions. New York: M.A. Liebert, 1989.

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Clarke, Hilary. In vivo and in vitro studies on cyclosporine-induced nephrotoxicity. Dublin: University College Dublin, 1997.

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Atterwill, C. K., and C. E. Steele. In vitro methods in toxicology. Cambridge: Cambridge University Press, 2009.

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Buchteile zum Thema "Toxicity testing In vitro"

1

Repetto, Guillermo, Consuelo Alvarez Herrera, Raquel Rojas, Ana del Peso, and Sara Maisanaba. "In Vitro Toxicity Testing." In Toxicology for the Health and Pharmaceutical Sciences, 119–41. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780203730584-8.

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Atterwill, Chris K. "Alternative Method of Assessing Toxicity." In In Vitro Toxicity Testing Protocols, 1–9. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:1.

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Clothier, Richard H. "The FRAME Cytotoxicity Test (Kenacid Blue)." In In Vitro Toxicity Testing Protocols, 109–18. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:109.

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White, David J., and Chris Seaman. "LLC-RK1 Cell Screening Test for Nephrotoxicity." In In Vitro Toxicity Testing Protocols, 11–16. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:11.

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Fiskesjö, Geirid. "Allium Test." In In Vitro Toxicity Testing Protocols, 119–27. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:119.

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Walum, Erik, and Anna Forsby. "Measurement of Cell Membrane Toxicity by Means of 2-Deoxy-D-Glucose." In In Vitro Toxicity Testing Protocols, 129–35. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:129.

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Supino, Rosa. "MTT Assays." In In Vitro Toxicity Testing Protocols, 137–49. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:137.

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Bianchi, Vera. "V79 Cytotoxicity Test for Membrane Damage." In In Vitro Toxicity Testing Protocols, 151–60. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:151.

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Blein-Sella, Odile, and Monique Adolphe. "SIRC Cytotoxicity Test." In In Vitro Toxicity Testing Protocols, 161–67. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:161.

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Blein-Sella, Odile, and Monique Adolphe. "Rabbit Articular Chondrocyte Functional Toxicity Test." In In Vitro Toxicity Testing Protocols, 169–75. Totowa, NJ: Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:169.

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Konferenzberichte zum Thema "Toxicity testing In vitro"

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Rommel, Christina E., Christian Dierker, Angelika Vollmer, Steffi Ketelhut, Björn Kemper, and Juergen Schnekenburger. "Multimodal label-free in vitro toxicity testing with digital holographic microscopy." In SPIE Photonics Europe, edited by Jürgen Popp, Valery V. Tuchin, Dennis L. Matthews, Francesco S. Pavone, and Paul Garside. SPIE, 2014. http://dx.doi.org/10.1117/12.2054374.

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Rozman, Iza, Alja Štern, and Bojana Žegura. "New Approaches for Testing the (Geno)Toxic Activity of Nano-particles In Vitro." In Socratic lectures 10. University of Lubljana Press, 2024. http://dx.doi.org/10.55295/psl.2024.ii8.

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Abstract:The safety of nanomaterials, whether they are made of natural or artificial substances, represents a significant challenge because nanotechnology, as a young and up-and-coming field, is developing very quickly, while nanotoxicology and nanoecotoxicology are falling behind. Since the production, use, and consequently, the exposure of people to nanomaterials is increasing significantly, the acquisition of data on potential acute and chronic toxicity plays a crucial role. It is known that nanomaterials due to their high surface-to-volume ratio, high reactivity, and unique physical, chemi

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Gernand, Jeremy M. "Limitations on the Reliability of In Vitro Predictive Toxicity Models to Predict Pulmonary Toxicity in Rodents." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-67151.

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Given the rapidly proliferating varieties of nanomaterials and ongoing concerns that these novel materials may pose emerging occupational and environmental risks, combined with the possibility that each variety might pose a different unique risk due to the unique combination of material properties, researchers and regulators have been searching for methods to identify hazards and prioritize materials for further testing. While several screening tests and toxic risk models have been proposed, most have relied on cellular-level in vitro data. This foundation enables answers to be developed quick

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Stoeger, T., O. Schmid, D. Dittberner, S. Takenaka, and H. Schulz. "Deducing the Inflammatory In Vivo Toxicity of Combustion Derived Nanoparticles from In Vitro Testing." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5240.

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George, Subin M., and Hyejin Moon. "Digital Microfluidic Platform for 3-D Tissue Based High Throughput Screening." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53995.

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Pharmaceutical drug development requires exhaustive testing of potential drugs in before animal and human clinical trials. Only one in ten drugs entering clinical trials receive the final approval. Most drugs fail in later stages due to lack of efficacy or toxicity which are discovered later on, after having cleared in vitro trials [1]. This highlights the need for improved laboratory testing methods to screen out failure candidates. It should be noted that 3-dimensional (3D) tissue constructs provide a better environment to mimic physiological processes as compared to conventional 2-dimension

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Gernand, Jeremy M., and Elizabeth A. Casman. "Selecting Nanoparticle Properties to Mitigate Risks to Workers and the Public: A Machine Learning Modeling Framework to Compare Pulmonary Toxicity Risks of Nanomaterials." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62687.

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Due to their size and unique chemical properties, nanomaterials have the potential to interact with living organisms in novel ways, leading to a spectrum of negative consequences. Though a relatively new materials science, already nanomaterial variants in the process of becoming too numerous to be screened for toxicity individually by traditional and expensive animal testing. As with conventional pollutants, the resulting backlog of untested new materials means that interim industry and regulatory risk management measures may be mismatched to the actual risk. The ability to minimize toxicity r

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RAMETTA, GABRIELLA, VERA LA FERRARA, and GIROLAMO DI FRANCIA. "NANOMATERIALS TOXICITY: AN IN-VITRO INVESTIGATION." In Proceedings of the 12th Italian Conference. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812833594_0013.

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Sabata, R. W., and E. L. Dewailly. "Toxicity Testing With Bioluminescence." In Offshore Technology Conference. Offshore Technology Conference, 1990. http://dx.doi.org/10.4043/6301-ms.

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Sabaté, R. W., A. V. Stiffey, E. L. Dewailly, A. A. Hinds, and G. J. Vieaux. "Portable, Accurate Toxicity Testing." In Offshore Technology Conference. Offshore Technology Conference, 1994. http://dx.doi.org/10.4043/7406-ms.

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Massányi, Peter, Grzegorz Formicki, N. Lukáč, J. Slivková, J. Kováčik, R. Toman, Łukasz Binkowski, Agnieszka Greń, and Robert Stawarz. "REPRODUCTIVE TOXICITY OF MERCURY IN VIVO AND IN VITRO." In XVIII INTERNATIONAL SCIENTIFIC CONFERENCE RISK FACTORS OF FOOD CHAIN 2017. Uniwersytet Pedagogiczny w Krakowie, 2017. http://dx.doi.org/10.24917/9788380840973.12.

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Berichte der Organisationen zum Thema "Toxicity testing In vitro"

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Hawkins, Brian T., and Sonia Grego. A Better, Faster Road From Biological Data to Human Health: A Systems Biology Approach for Engineered Cell Cultures. RTI Press, June 2017. http://dx.doi.org/10.3768/rtipress.2017.rb.0015.1706.

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Traditionally, the interactions of drugs and toxicants with human tissue have been investigated in a reductionist way—for example, by focusing on specific molecular targets and using single-cell-type cultures before testing compounds in whole organisms. More recently, “systems biology” approaches attempt to enhance the predictive value of in vitro biological data by adopting a comprehensive description of biological systems and using computational tools that are sophisticated enough to handle the complexity of these systems. However, the utility of computational models resulting from these eff

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Committee on Toxicology. COT FSA PBPK for Regulators Workshop Report 2021. Food Standards Agency, April 2024. http://dx.doi.org/10.46756/sci.fsa.tyy821.

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The future of food safety assessment in the UK depends on the Food Standards Agency’s (FSA) adaptability and flexibility in responding to and adopting the accelerating developments in science and technology. The Tox21 approach is an example of one recent advancement in the development of alternative toxicity testing approaches and computer modelling strategies for the evaluation of hazard and exposure (New Approach Methodologies (NAMs). A key aspect is the ability to link active concentrations in vitro to likely concentrations in vivo, for which physiologically based pharmacokinetic (PBPK) mod

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Dean, Jay B. Hyperbaric Imaging Equipment: Fluorescence Microscopy for In Vitro Studies of Oxygen Toxicity. Fort Belvoir, VA: Defense Technical Information Center, August 2004. http://dx.doi.org/10.21236/ada425309.

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Levine, Barry S., Richard H. San, and Patrick D. Curry. In Vitro Mutagenicity Testing of WR6026 Hydrochloride. Fort Belvoir, VA: Defense Technical Information Center, December 1994. http://dx.doi.org/10.21236/ada640560.

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Geiss, Kevin T., Dan L. Polland, and John M. Frazier. Toxicity of Experimental Jet Fuel System Ice-Inhibiting Agents: I. In Vitro Dosimetry. Fort Belvoir, VA: Defense Technical Information Center, October 1999. http://dx.doi.org/10.21236/ada453145.

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Beitel, Jesse J., Craig L. Beyler, Lawrence A. McKenna, and Frederick W. Williams. Overview of Smoke Toxicity Testing and Regulations. Fort Belvoir, VA: Defense Technical Information Center, April 1998. http://dx.doi.org/10.21236/ada342016.

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Rabalais, Lauren, Jennifer Laird, Alan Kennedy, John Farrar, Guilherme Lotufo, and James Biedenbach. Acute Toxicity Testing and Culture Methods for Calanoid Copepods in Water Column (Elutriate) Toxicity Evaluations. Environmental Laboratory (U.S.), July 2018. http://dx.doi.org/10.21079/11681/27968.

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Ruffing, Anne, Travis Jensen, and Lucas Strickland. NMSBA: Aken Technologies Final Report: Toxicity Testing of Liquidoff. Office of Scientific and Technical Information (OSTI), February 2015. http://dx.doi.org/10.2172/1171600.

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Ruffing, Anne, Travis J. Jensen, Lucas Marshall Strickland, Nadeya C. Rader, and Bryan Carson. NMSBA: Aken Technologies. Final Report: Toxicity Testing of Liquidoff. Office of Scientific and Technical Information (OSTI), January 2015. http://dx.doi.org/10.2172/1177379.

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Albertini, R. J. The development of in vitro mutagenicity testing systems using t-lymphocytes. Office of Scientific and Technical Information (OSTI), February 1998. http://dx.doi.org/10.2172/615639.

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