Zeitschriftenartikel: „TOR produkty“

1

Constapel, Petra. „Vanishing of tor and torsion in tensor products“. Communications in Algebra 24, Nr. 3 (Januar 1996): 833–46. http://dx.doi.org/10.1080/00927879608825604.

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2

Nasseh, Saeed, und Sean Sather-Wagstaff. „Vanishing of Ext and Tor over fiber products“. Proceedings of the American Mathematical Society 145, Nr. 11 (22.06.2017): 4661–74. http://dx.doi.org/10.1090/proc/13633.

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3

Huneke, Craig, und Roger Wiegand. „Tensor products of modules and the rigidity of Tor“. Mathematische Annalen 299, Nr. 1 (Mai 1994): 449–76. http://dx.doi.org/10.1007/bf01459794.

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4

Lazăr, C. „ADVANCED GLYCATION END PRODUCTS IN EXPERIMENTAL OVARIAN TORSION/DETORSION“. Biological Markers in Fundamental and Clinical Medicine (collection of abstracts) 1, Nr. 4 (29.12.2017): 10–11. http://dx.doi.org/10.29256/v.01.04.2017.escbm03.

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5

Häfner, Friedrich. „The clay and natural stones industry in the Westerwald. Deposits, extracting methods, products“. Jahresberichte und Mitteilungen des Oberrheinischen Geologischen Vereins 101 (11.04.2019): 151–68. http://dx.doi.org/10.1127/jmogv/101/0006.

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6

Vetoshkina, I. S., V. S. Solodov, S. P. Subbotin, E. V. Vasileva, T. G. Cherkasova und A. V. Nevedrov. „Valuable Products from Coal Tar“. Coke and Chemistry 62, Nr. 2 (Februar 2019): 66–68. http://dx.doi.org/10.3103/s1068364x1902011x.

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7

Khaokhrueamuang, Amnaj, Piyaporn Chueamchaitrakun, Warinthorn Kachendecha, Yuki Tamari und Kazuyoshi Nakakoji. „Functioning tourism interpretation on consumer products at the tourist generating region through tea tourism“. International Journal of Culture, Tourism and Hospitality Research 15, Nr. 3 (18.06.2021): 340–54. http://dx.doi.org/10.1108/ijcthr-08-2020-0187.

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Purpose This paper aims to clarify the functions of tourism interpretations of consumer products in a tourist-generating region (TGR) as a means of marketing the tourist destination region (TDR) through tea tourism. Design/methodology/approach This is a case study of the Thai Shizuoka Green Tea brand working to promote tea tourism in Shizuoka, Japan. It is used to identify the functions of tourism interpretations of consumer products in a TGR related to the concept of brand identity. This paper assessed Thai consumers’ opinions on the efficiency of tourism interpretation through a sample of 404 questionnaires and with interviews of ten young females, the primary respondents. Findings Tourism interpretations of the TGR’s consumer products are important for promoting the TDR through five premises: 1) motivating visitors to visit the destination, 2) communicating the place’s meaning, 3) targeting potential tourists, 4) differentiating the destination from other sites and 5) activating value co-creation. Premises 1 and 2 were assumed to stem from visitors’ enjoyment of the tea; the packaging motivated their visit to Shizuoka, its origin. Premise 3 concerns young women who view the product as a premium healthy drink. Premises 4 and 5 are based on the brand’s essence, implying the tea company’s partnership between Thailand and Japan. Originality/value Tourism interpretation plays a significant role in TDRs’ success; however, it can be implemented with other consumer products and an efficient brand identity, to create an image of a destination.

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Inoki, Ken, Hongjiao Ouyang, Yong Li und Kun-Liang Guan. „Signaling by Target of Rapamycin Proteins in Cell Growth Control“. Microbiology and Molecular Biology Reviews 69, Nr. 1 (März 2005): 79–100. http://dx.doi.org/10.1128/mmbr.69.1.79-100.2005.

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SUMMARY Target of rapamycin (TOR) proteins are members of the phosphatidylinositol kinase-related kinase (PIKK) family and are highly conserved from yeast to mammals. TOR proteins integrate signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth. The ribosomal S6 kinase 1 (S6K) and eukaryotic initiation factor 4E binding protein 1(4EBP1) are two cellular targets of TOR kinase activity and are known to mediate TOR function in translational control in mammalian cells. However, the precise molecular mechanism of TOR regulation is not completely understood. One of the recent breakthrough studies in TOR signaling resulted in the identification of the tuberous sclerosis complex gene products, TSC1 and TSC2, as negative regulators for TOR signaling. Furthermore, the discovery that the small GTPase Rheb is a direct downstream target of TSC1-TSC2 and a positive regulator of the TOR function has significantly advanced our understanding of the molecular mechanism of TOR activation. Here we review the current understanding of the regulation of TOR signaling and discuss its function as a signaling nexus to control cell growth during normal development and tumorigenesis.

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9

Ko, Darae, Alok Kapoor, Adam J. Rose, Amresh D. Hanchate, Donald Miller, Michael R. Winter, Joseph N. Palmisano et al. „Temporal trends in pharmacologic prophylaxis for venous thromboembolism after hip and knee replacement in older adults“. Vascular Medicine 25, Nr. 5 (09.06.2020): 450–59. http://dx.doi.org/10.1177/1358863x20927096.

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Trends in prescription for venous thromboembolism (VTE) prophylaxis following total hip (THR) and knee replacement (TKR) since the approval of direct oral anticoagulants (DOACs) and the 2012 guideline endorsement of aspirin are unknown, as are the risks of adverse events. We examined practice patterns in the prescription of prophylaxis agents and the risk of adverse events during the in-hospital period (the ‘in-hospital sample’) and 90 days following discharge (the ‘discharge sample’) among adults aged ⩾ 65 undergoing THR and TKR in community hospitals in the Institute for Health Metrics database over a 30-month period during 2011 to 2013. Eligible medications included fondaparinux, DOACs, low molecular weight heparin (LMWH), other heparin products, warfarin, and aspirin. Outcomes were validated by physician review of source documents: VTE, major hemorrhage, cardiovascular events, and death. The in-hospital and the discharge samples included 10,503 and 5722 adults from 65 hospitals nationwide, respectively (mean age 73, 74 years; 61%, 63% women). Pharmacologic prophylaxis was near universal during the in-hospital period (93%) and at discharge (99%). DOAC use increased substantially and was the prophylaxis of choice for nearly a quarter (in-hospital) and a third (discharge) of the patients. Aspirin was the sole discharge prophylactic agent for 17% and 19% of patients undergoing THR and TKR, respectively. Warfarin remained the prophylaxis agent of choice for patients aged 80 years and older. The overall risk of adverse events was low, at less than 1% for both the in-hospital and discharge outcomes. The low number of adverse events precluded statistical comparison of prophylaxis regimens.

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Willison, K. R., G. Hynes, P. Davies, A. Goldsborough und V. A. Lewis. „Expression of three t-complex genes, Tcp-1, D17Leh117c3, and D17Leh66, in purified murine spermatogenic cell populations“. Genetics Research 56, Nr. 2-3 (Oktober 1990): 193–201. http://dx.doi.org/10.1017/s0016672300035291.

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SummaryTransmission ratio distortion (TRD) is a property of the complete t-haplotype which results in the preferential transmission of the t-haplotype chromosome from heterozygous t/+ males to the majority of the progeny. Available data suggest that in t/+ males, a dysfunction of the wild-type sperm within the female reproductive tract is responsible for the observed deviation from Mendelian segregation ratios. Genetically, Lyon has shown that multiple loci within the t-complex are required for maximum levels of TRD. These loci include multiple t-complex distorters (Teds) which act upon a single t-complex responder (Ter). Testis-expressed genes have been cloned which map to the same subregions of the t-complex as the Teds and Ter and are thus considered candidate genes for the products of these loci. To begin to understand how the products of these loci biochemically control TRD, the expression of three TRD-candidate genes (Tcp-1, D17Leh117c3, and D17Leh66) has been determined in populations of spermatocytes and differentiated spermatids purified to near homogeneity by unit gravity sedimentation. Fractions covering the entire gradient were analysed resulting in a more accurate picture of the precise timing of expression than previously reported. Transcription of all three genes was up-regulated in pachytene primary spermatocytes and persisted at stable levels through the haploid spermatid stages. Significantly, only levels of mRNA encoded by D17Leh66, the candidate gene for Tcr, increased from early round to elongating-stage spermatids. If this pattern of expression does, in fact, represent Tcr, these data provide the first direct evidence that wild-type and t-haplotype Tcr elements could be differentially expressed in haploid spermatids.

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11

Kozlov, A. P., T. G. Cherkasova, S. V. Frolov, S. P. Subbotin und V. S. Solodov. „Innovative Coal-Tar Products at PAO Koks“. Coke and Chemistry 63, Nr. 7 (Juli 2020): 344–50. http://dx.doi.org/10.3103/s1068364x20070054.

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12

DEBOER, R. „Allelic variations of human TCR gene products“. Immunology Today 12, Nr. 5 (Mai 1991): 169. http://dx.doi.org/10.1016/0167-5699(91)90083-6.

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13

Martsinkovsky, Alex, und Jeremy Russell. „Injective stabilization of additive functors, III. Asymptotic stabilization of the tensor product“. Algebra and Discrete Mathematics 31, Nr. 1 (2021): 120–51. http://dx.doi.org/10.12958/adm1728.

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The injective stabilization of the tensor product is subjected to an iterative procedure that utilizes its bifunctor property. The limit of this procedure, called the asymptotic stabilization of the tensor product, provides a homological counterpart of Buchweitz's asymptotic construction of stable cohomology. The resulting connected sequence of functors is isomorphic to Triulzi's J-completion of the Tor functor. A comparison map from Vogel homology to the asymptotic stabilization of the tensor product is constructed and shown to be always epic. The category of finitely presented functors is shown to be complete and cocomplete. As a consequence, the inert injective stabilization of the tensor product with fixed variable a finitely generated module over an artin algebra is shown to be finitely presented. Its defect and consequently all right-derived functors are determined. New notions of asymptotic torsion and cotorsion are introduced and are related to each other.

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14

Tasca, Karen Ingrid, Camila Renata Correa, Juliana Trindade Caleffi, Monica Banwart Mendes, Mariana Gatto, Vanessa Martinez Manfio, Caio Cavassan de Camargo, Francilene Capel Tavares, Mara Biasin und Lenice do Rosário de Souza. „Asymptomatic HIV People Present Different Profiles of sCD14, sRAGE, DNA Damage, and Vitamins, according to the Use of cART and CD4+ T Cell Restoration“. Journal of Immunology Research 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/7531718.

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We aimed to analyze markers of immune activation, inflammation, and oxidative stress in 92 asymptomatic HIV-infected patients according to the adequate (AR, >500 cells/mm3) or inadequate (IR, <500 cells/mm3) CD4+ T recovery and the presence or absence of antiretroviral treatment (cART). In relation to those newly diagnosed, they were divided into two groups, cART-naïve IR (nIR) and cART-naïve AR (nAR). Among those diagnosed more than five years ago, the following division was made: the cART-naïve long-term nonprogressors (LTNP); patient under cART and AR (tAR); and patients under cART and IR (tIR). We investigated the expression of soluble receptor for advanced glycation end products (sRAGE), high-mobility group-box protein −1 (HMGB1), soluble CD14 (sCD14), IL-8, IL-10, 8-isoprostane, vitamins, and DNA damage. We observed higher levels of sRAGE in tAR as compared to nIR, nAR, LTNP, and more sCD14 than in nIR and nAR. As for IL-10 levels, we found nIR > nAR > LTNP > tAR > tIR. Higher levels of 8-isoprostane were observed in nIR. LTNP presented a higher retinol dosage than tAR and less genotoxic damage induced by oxidative stress than the other groups. We suggest that the therapy, despite being related to lesser immune activation and inflammation, alters the vitamin profile and consequently increases the oxidative stress of patients. In addition, the lowest genotoxic index for LTNP indicates that both VL and cART could be responsible for the increased DNA damage. More studies are needed to understand the influence of cART on persistent immune activation and inflammation.

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15

Wakimoto, Toshiyuki. „Toward the Dark Matter of Natural Products“. Chemical Record 17, Nr. 11 (18.04.2017): 1124–34. http://dx.doi.org/10.1002/tcr.201700009.

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16

Kishimoto, Shinji, Yuta Tsunematsu, Michio Sato und Kenji Watanabe. „Elucidation of Biosynthetic Pathways of Natural Products“. Chemical Record 17, Nr. 11 (07.04.2017): 1095–108. http://dx.doi.org/10.1002/tcr.201700015.

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17

Valishkevych, Bohdana V., Ruslana A. Vasylkovska, Liudmyla M. Lozinska und Halyna M. Semchyshyn. „Fructose-Induced Carbonyl/Oxidative Stress inS. cerevisiae: Involvement of TOR“. Biochemistry Research International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/8917270.

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The TOR (target of rapamycin) signaling pathway first described in the budding yeastSaccharomyces cerevisiaeis highly conserved in eukaryotes effector of cell growth, longevity, and stress response. TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated. Fructose is a more potent glycoxidation agent capable of producing greater amounts of reactive carbonyl (RCS) and oxygen species (ROS) than glucose. The increased RCS/ROS production, as a result of glycoxidationin vivo, is supposed to be involved in carbonyl/oxidative stress, metabolic disorders, and lifespan shortening of eukaryotes. In this work we aim to expand our understanding of how TOR is involved in carbonyl/oxidative stress caused by reducing monosaccharides. It was found that in fructose-grown compared with glucose-grown cells the level of carbonyl/oxidative stress markers was higher. The defects in the TOR pathway inhibited metabolic rate and suppressed generation of glycoxidation products in fructose-grown yeast.

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Elliott, Simon J., Colin B. O'Connell, Athanasia Koutsouris, Carl Brinkley, Michael S. Donnenberg, Gail Hecht und James B. Kaper. „A Gene from the Locus of Enterocyte Effacement That Is Required for Enteropathogenic Escherichia coli To Increase Tight-Junction Permeability Encodes a Chaperone for EspF“. Infection and Immunity 70, Nr. 5 (Mai 2002): 2271–77. http://dx.doi.org/10.1128/iai.70.5.2271-2277.2002.

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ABSTRACT Disruption of the barrier properties of the enterocyte tight junction is believed to be important in the pathogenesis of diarrhea caused by enteropathogenic Escherichia coli (EPEC). This phenotype can be measured in vitro as the ability of EPEC to reduce transepithelial resistance (TER) across enterocyte monolayers and requires the products of the locus of enterocyte effacement (LEE) and, in particular, the type III secreted effector protein EspF. We report a second LEE-encoded gene that is also necessary for EPEC to fully reduce TER. rorf10 is not necessary for EPEC adherence, EspADB secretion, or formation of attaching and effacing lesions. However, rorf10 mutants have a diminished TER phenotype, reduced intracellular levels of EspF, and a reduced ability to translocate EspF into epithelial cells. The product of rorf10 is a 14-kDa intracellular protein rich in α-helices that specifically interacts with EspF but not with Tir or other EPEC secreted proteins. These properties are consistent with the hypothesis that rorf10 encodes a type III secretion chaperone for EspF, and we rename this protein CesF, the chaperone for EPEC secreted protein F.

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Zanovelli Nalevaiko, Jaqueline, Paulo André Cremonez und Joel Gustavo Teleken. „UTILIZAÇÃO DE SUBPRODUTOS AGROINDUSTRIAIS NA PRODUÇÃO DE BRIQUETES“. Revista Brasileira de Engenharia de Biossistemas 15, Nr. 1 (20.04.2021): 1–26. http://dx.doi.org/10.18011/bioeng2021v15n1p1-26.

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O atual cenário energético mundial é de busca por combustíveis mais limpos e novas fontes de energia renováveis, com destaque à utilização de biomassa residual. O presente trabalho busca avaliar as características físico-químicas de briquetes produzidos a partir do bagaço da cana-de-açúcar, bagaço de mandioca e cama de aviário. Os subprodutos passaram por análises antes e após a briquetação. Foram produzidos briquetes com diferentes percentuais de mistura (M1, M2 e M3). Os briquetes produzidos apresentaram valores de eficiência energética, resistência mecânica e densidade aparente e energética coerentes com valores da literatura e de normativas internacionais. Em relação ao teor de cinzas nenhum deles se enquadra nos parâmetros europeus de fabricação de briquetes. A mistura com melhor eficiência energética foi M2, com poder calorífico de 16,41 MJ/kg e também o menor teor de cinzas, de 7,96%, e melhor relação C/H, porcentagem de hidrogênio e de carbono, sendo assim o de maior potencial energético de queima. A utilização de briquetes produzidos a partir de biomassa residual apresenta muitas vantagens, contribuindo em aspectos econômicos, sociais e ambientais.

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Tatsuta, Kuniaki, und Seijiro Hosokawa. „Total syntheses of polyketide-derived bioactive natural products“. Chemical Record 6, Nr. 4 (2006): 217–33. http://dx.doi.org/10.1002/tcr.20084.

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21

Gademann, Karl, und Joanna Kobylinska. „Antimalarial natural products of marine and freshwater origin“. Chemical Record 9, Nr. 3 (23.06.2009): 187–98. http://dx.doi.org/10.1002/tcr.200900001.

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22

Suzuki, Keisuke. „Lessons from total synthesis of hybrid natural products“. Chemical Record 10, Nr. 5 (27.09.2010): 291–307. http://dx.doi.org/10.1002/tcr.201000030.

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23

De Boer, Rob J. „Allelic variations of human TCR V gene products“. Immunology Today 12, Nr. 5 (Januar 1991): 169. http://dx.doi.org/10.1016/s0167-5699(05)80048-9.

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24

Posnet, David N. „Allelic variations of human TCR V gene products“. Immunology Today 11 (Januar 1990): 368–73. http://dx.doi.org/10.1016/0167-5699(90)90143-w.

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25

Han, Jing-Chun, und Chuang-Chuang Li. „Ruthenium-Catalyzed Metathesis Cascade Reactions in Natural Products Synthesis“. Chemical Record 17, Nr. 5 (24.10.2016): 499–517. http://dx.doi.org/10.1002/tcr.201600110.

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26

Lepoittevin, Jean-Pierre, ValÃ©rie Berl und Elena GimÃ©nez-Arnau. „Î±-methylene-Î³-butyrolactones: versatile skin bioactive natural products“. Chemical Record 9, Nr. 5 (21.12.2009): 258–70. http://dx.doi.org/10.1002/tcr.200900013.

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27

Yoon, Janghyeok, Hyunseok Park, Wonchul Seo, Jae-Min Lee, Byoung-youl Coh und Jonghwa Kim. „Technology opportunity discovery (TOD) from existing technologies and products: A function-based TOD framework“. Technological Forecasting and Social Change 100 (November 2015): 153–67. http://dx.doi.org/10.1016/j.techfore.2015.04.012.

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28

Serkovskaya, G. S. „Carcinogenity of medicinal ointments containing crude oil, petroleum products, coal tar, or wood tar“. Chemistry and Technology of Fuels and Oils 33, Nr. 6 (November 1997): 368–72. http://dx.doi.org/10.1007/bf02770089.

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29

Kita, Masaki, und Daisuke Uemura. „Marine huge molecules: the longest carbon chains in natural products“. Chemical Record 10, Nr. 1 (08.03.2010): 48–52. http://dx.doi.org/10.1002/tcr.200900030.

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30

Kigoshi, Hideo, und Ichiro Hayakawa. „Marine cytotoxic macrolides haterumalides and biselides, and related natural products“. Chemical Record 7, Nr. 4 (2007): 254–64. http://dx.doi.org/10.1002/tcr.20119.

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31

Zhang, Yun, Jianxian Gong und Zhen Yang. „Efficient Total Synthesis of Bioactive Natural Products: A Personal Record“. Chemical Record 14, Nr. 4 (14.07.2014): 606–22. http://dx.doi.org/10.1002/tcr.201402015.

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32

Yadav, S. K., A. Kumari und V. Kumar. „Nanotechnology: A Tool to Enhance Therapeutic Values of Natural Plant Products“. Trends in Medical Research 7, Nr. 2 (01.02.2012): 34–42. http://dx.doi.org/10.3923/tmr.2012.34.42.

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33

Yin, Xiaoqin, Chenchen Dong und Chuang Liu. „Global Value Chain Restructuring in the trade of Knocked Down products“. Transactions of FAMENA 41, Nr. 1 (26.04.2017): 91–98. http://dx.doi.org/10.21278/tof.41108.

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Yang, He, und Wenjun Tang. „Efficient Enantioselective Syntheses of Chiral Natural Products Facilitated by Ligand Design“. Chemical Record 20, Nr. 1 (26.04.2019): 23–40. http://dx.doi.org/10.1002/tcr.201900003.

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35

Strømgaard, Kristian. „Natural products as tools for studies of ligand-gated ion channels“. Chemical Record 5, Nr. 4 (2005): 229–39. http://dx.doi.org/10.1002/tcr.20048.

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36

Uemura, Daisuke. „Bioorganic studies on marine natural products—diverse chemical structures and bioactivities“. Chemical Record 6, Nr. 5 (2006): 235–48. http://dx.doi.org/10.1002/tcr.20087.

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37

Shoji, Mitsuru, Eisuke Kato, Yoko Nakamura, Tomohiko Fujii, Yoshiyuki Manabe und Minoru Ueda. „Bioorganic studies on plant movement, from natural products to its receptor“. Chemical Record 6, Nr. 6 (2006): 344–55. http://dx.doi.org/10.1002/tcr.20102.

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38

Li, Y., P. Szabo, M. A. Robinson, B. Dong und D. N. Posnett. „Allelic variations in the human T cell receptor V beta 6.7 gene products.“ Journal of Experimental Medicine 171, Nr. 1 (01.01.1990): 221–30. http://dx.doi.org/10.1084/jem.171.1.221.

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Polymorphisms of human TCR gene products have been suggested by the description of a mAb, OT145, that identifies a subset of TCRs in some individuals but not in others (6). Here we demonstrate that this mAb detects a TCR allotype of the V beta 6.7 gene. Two allelic products of this V gene differ by two nonconservative amino acid substitutions. The mAb OT145 appears to react with V beta 6.7 a gene products ("+" allele), but not with V beta 6.7b gene products ("-" allele). This represents the first direct demonstration that TCR V gene allotypes exist and provides a possible explanation for immune responses under the control of TCR V genes and for disease associations with TCR V genes.

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Musina, G. N., A. T. Takibayeva, I. V. Kulakov, A. A. Zhorabek und G. A. Shakhmetova. „PROCESSING OF COAL TAR INTO PETROCHEMICALS AND FUEL PRODUCTS“. SERIES CHEMISTRY AND TECHNOLOGY 4, Nr. 448 (15.08.2021): 40–47. http://dx.doi.org/10.32014/2021.2518-1491.65.

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40

Ohmori, Ken. „Synthetic challenge to ubiquitous natural products from plant origin: flavan-derived polyphenols“. Chemical Record 11, Nr. 5 (06.09.2011): 252–59. http://dx.doi.org/10.1002/tcr.201100026.

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41

Chida, Noritaka, und Takaaki Sato. „Synthesis of Natural Products Containing Cyclohexane Units Utilizing the Ferrier Carbocyclization Reaction“. Chemical Record 14, Nr. 4 (14.07.2014): 592–605. http://dx.doi.org/10.1002/tcr.201402024.

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42

Li, Yang, Renja Romey-Glüsing, Navid Tahan Zadeh, Jakob von Frieling, Julia Hoffmann, Patricia Huebbe, Iris Bruchhaus, Gerald Rimbach, Christine Fink und Thomas Roeder. „Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling“. Nutrients 12, Nr. 4 (22.04.2020): 1172. http://dx.doi.org/10.3390/nu12041172.

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Algal products are well known for their health promoting effects. Nonetheless, an in depth understanding of the underlying molecular mechanisms is still only fragmentary. Here, we show that aqueous furbelow extracts (brown algae, Saccorhiza polyschides) lengthen the life of both sexes of the fruit fly Drosophila melanogaster substantially, if used as nutritional additives to conventional food. This life prolonging effect became even more pronounced in the presence of stressors, such as high-fat dieting of living under drought conditions. Application of the extracts did not change food intake, excretion, or other major physiological parameters. Nevertheless, effects on the intestinal microbiota were observed, leading to an increased species richness, which is usually associated with healthy conditions. Lifespan extension was not observed in target of rapamycin (TOR)-deficient animals, implying that functional TOR signaling is necessary to unfold the positive effects of brown algae extract (BAE) on this important trait. The lack of life lengthening in animals with deregulated TOR signaling exclusively targeted to body fat showed that this major energy storage organ is instrumental for transmitting these effects. In addition, expression of Imaginal morphogenesis protein-Late 2 (Imp-L2), an effective inhibitor of insulin signaling implies that BAE exerts their positive effects through interaction with the tightly interwoven TOR- and insulin-signaling systems, although insulin levels were not directly affected by this intervention.

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Galas, Radovan, Milan Omasta und Martin Hartl. „Top-of-Rail Lubricants: Potential Risks and Benefits“. Proceedings 2, Nr. 16 (17.09.2018): 1140. http://dx.doi.org/10.3390/proceedings2161140.

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Top-of-rail (TOR) lubricants represent modern approach for friction modification between wheel and rail. The main goal of this study was to investigate potential risks and benefits associated with the application of these products, especially in terms of adhesion, wear, and noise. For this purpose, both laboratory and field experiments were carried out.

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Isenegger, Patrick G., und Andreas Pfaltz. „Mass Spectrometric Back Reaction Screening of Quasi-Enantiomeric Products as a Mechanistic Tool“. Chemical Record 16, Nr. 6 (15.07.2016): 2534–43. http://dx.doi.org/10.1002/tcr.201600072.

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Lascano, Santiago, Marie Lopez und Paola B. Arimondo. „Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers“. Chemical Record 18, Nr. 12 (Dezember 2018): 1854–76. http://dx.doi.org/10.1002/tcr.201800133.

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Shiao, Ming-Shi. „Natural products of the medicinal fungusGanoderma lucidum: Occurrence, biological activities, and pharmacological functions“. Chemical Record 3, Nr. 3 (Juli 2003): 172–80. http://dx.doi.org/10.1002/tcr.10058.

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Matsushima, Tatsuo, Izabela Rzeznicka und Yunsheng Ma. „Spatial distributions of desorbing products in basic catalytic processes and surface nano-structures“. Chemical Record 5, Nr. 2 (2005): 81–93. http://dx.doi.org/10.1002/tcr.20036.

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Ichikawa, Satoshi. „Function-Oriented Synthesis: How to Design Simplified Analogues of Antibacterial Nucleoside Natural Products?“ Chemical Record 16, Nr. 3 (29.03.2016): 1106–15. http://dx.doi.org/10.1002/tcr.201500247.

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Huijnen, Vincent, Kazuyuki Miyazaki, Johannes Flemming, Antje Inness, Takashi Sekiya und Martin G. Schultz. „An intercomparison of tropospheric ozone reanalysis products from CAMS, CAMS interim, TCR-1, and TCR-2“. Geoscientific Model Development 13, Nr. 3 (26.03.2020): 1513–44. http://dx.doi.org/10.5194/gmd-13-1513-2020.

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Abstract. Global tropospheric ozone reanalyses constructed using different state-of-the-art satellite data assimilation systems, prepared as part of the Copernicus Atmosphere Monitoring Service (CAMS-iRean and CAMS-Rean) as well as two fully independent reanalyses (TCR-1 and TCR-2, Tropospheric Chemistry Reanalysis), have been intercompared and evaluated for the past decade. The updated reanalyses (CAMS-Rean and TCR-2) generally show substantially improved agreements with independent ground and ozone-sonde observations over their predecessor versions (CAMS-iRean and TCR-1) for diurnal, synoptical, seasonal, and interannual variabilities. For instance, for the Northern Hemisphere (NH) mid-latitudes the tropospheric ozone columns (surface to 300 hPa) from the updated reanalyses show mean biases to within 0.8 DU (Dobson units, 3 % relative to the observed column) with respect to the ozone-sonde observations. The improved performance can likely be attributed to a mixture of various upgrades, such as revisions in the chemical data assimilation, including the assimilated measurements, and the forecast model performance. The updated chemical reanalyses agree well with each other for most cases, which highlights the usefulness of the current chemical reanalyses in a variety of studies. Meanwhile, significant temporal changes in the reanalysis quality in all the systems can be attributed to discontinuities in the observing systems. To improve the temporal consistency, a careful assessment of changes in the assimilation configuration, such as a detailed assessment of biases between various retrieval products, is needed. Our comparison suggests that improving the observational constraints, including the continued development of satellite observing systems, together with the optimization of model parameterizations such as deposition and chemical reactions, will lead to increasingly consistent long-term reanalyses in the future.

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Yoon, Sang Sun, und John J. Mekalanos. „2,3-Butanediol Synthesis and the Emergence of the Vibrio cholerae El Tor Biotype“. Infection and Immunity 74, Nr. 12 (02.10.2006): 6547–56. http://dx.doi.org/10.1128/iai.00695-06.

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ABSTRACT Vibrio cholerae is an aquatic bacterium that causes the severe diarrheal disease cholera. V. cholerae strains of the O1 serogroup exist as two biotypes, classical and El Tor. Toxigenic strains of the El Tor biotype emerged to cause the seventh pandemic of cholera in 1961 and subsequently displaced strains of the classical biotype both in the environment and as a cause of cholera within a decade. The factors that drove emergence of the El Tor biotype and the displacement of the classical biotype are unknown. Here, we show a unique difference in carbohydrate metabolism between these two biotypes. When grown with added carbohydrates, classical biotype strains generated a sharp decrease in medium pH, resulting in loss of viability. However, growth of El Tor biotype strain N16961 was enhanced due to its ability to produce 2,3-butanediol, a neutral fermentation end product, and suppress the accumulation of organic acids. An N16961 mutant (SSY01) defective in 2,3-butanediol synthesis showed the same defect in growth that classical biotype strains show in media rich in carbohydrates. Importantly, the SSY01 mutant was attenuated in its ability to colonize the intestines of infant mice, suggesting that host carbohydrates may be available to V. cholerae within the intestinal environment. Similarly, the SSY01 mutant failed to develop biofilms when utilizing N-acetyl-d-glucosamine as a carbon source. Because growth on N-acetyl-d-glucosamine likely reflects the ability of a strain to grow on chitin in certain aquatic environments, we conclude that the strains of classical biotype are likely defective compared to those of El Tor in growth in any environmental niche that is rich in chitin and/or other metabolizable carbohydrates. We propose that the ability to metabolize sugars without production of acid by-products might account for the improved evolutionary fitness of the V. cholerae El Tor biotype compared to that of the classical biotype both as a global cause of cholera and as an environmental organism.

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