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Zeitschriftenartikel zum Thema "TOR products"
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Constapel, Petra. „Vanishing of tor and torsion in tensor products“. Communications in Algebra 24, Nr. 3 (Januar 1996): 833–46. http://dx.doi.org/10.1080/00927879608825604.
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Nasseh, Saeed, und Sean Sather-Wagstaff. „Vanishing of Ext and Tor over fiber products“. Proceedings of the American Mathematical Society 145, Nr. 11 (22.06.2017): 4661–74. http://dx.doi.org/10.1090/proc/13633.
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3
Huneke, Craig, und Roger Wiegand. „Tensor products of modules and the rigidity of Tor“. Mathematische Annalen 299, Nr. 1 (Mai 1994): 449–76. http://dx.doi.org/10.1007/bf01459794.
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4
Lazăr, C. „ADVANCED GLYCATION END PRODUCTS IN EXPERIMENTAL OVARIAN TORSION/DETORSION“. Biological Markers in Fundamental and Clinical Medicine (collection of abstracts) 1, Nr. 4 (29.12.2017): 10–11. http://dx.doi.org/10.29256/v.01.04.2017.escbm03.
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Inoki, Ken, Hongjiao Ouyang, Yong Li und Kun-Liang Guan. „Signaling by Target of Rapamycin Proteins in Cell Growth Control“. Microbiology and Molecular Biology Reviews 69, Nr. 1 (März 2005): 79–100. http://dx.doi.org/10.1128/mmbr.69.1.79-100.2005.
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SUMMARY Target of rapamycin (TOR) proteins are members of the phosphatidylinositol kinase-related kinase (PIKK) family and are highly conserved from yeast to mammals. TOR proteins integrate signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth. The ribosomal S6 kinase 1 (S6K) and eukaryotic initiation factor 4E binding protein 1(4EBP1) are two cellular targets of TOR kinase activity and are known to mediate TOR function in translational control in mammalian cells. However, the precise molecular mechanism of TOR regulation is not completely understood. One of the recent breakthrough studies in TOR signaling resulted in the identification of the tuberous sclerosis complex gene products, TSC1 and TSC2, as negative regulators for TOR signaling. Furthermore, the discovery that the small GTPase Rheb is a direct downstream target of TSC1-TSC2 and a positive regulator of the TOR function has significantly advanced our understanding of the molecular mechanism of TOR activation. Here we review the current understanding of the regulation of TOR signaling and discuss its function as a signaling nexus to control cell growth during normal development and tumorigenesis.
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Valishkevych, Bohdana V., Ruslana A. Vasylkovska, Liudmyla M. Lozinska und Halyna M. Semchyshyn. „Fructose-Induced Carbonyl/Oxidative Stress inS. cerevisiae: Involvement of TOR“. Biochemistry Research International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/8917270.
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The TOR (target of rapamycin) signaling pathway first described in the budding yeastSaccharomyces cerevisiaeis highly conserved in eukaryotes effector of cell growth, longevity, and stress response. TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated. Fructose is a more potent glycoxidation agent capable of producing greater amounts of reactive carbonyl (RCS) and oxygen species (ROS) than glucose. The increased RCS/ROS production, as a result of glycoxidationin vivo, is supposed to be involved in carbonyl/oxidative stress, metabolic disorders, and lifespan shortening of eukaryotes. In this work we aim to expand our understanding of how TOR is involved in carbonyl/oxidative stress caused by reducing monosaccharides. It was found that in fructose-grown compared with glucose-grown cells the level of carbonyl/oxidative stress markers was higher. The defects in the TOR pathway inhibited metabolic rate and suppressed generation of glycoxidation products in fructose-grown yeast.
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Galas, Radovan, Milan Omasta und Martin Hartl. „Top-of-Rail Lubricants: Potential Risks and Benefits“. Proceedings 2, Nr. 16 (17.09.2018): 1140. http://dx.doi.org/10.3390/proceedings2161140.
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Top-of-rail (TOR) lubricants represent modern approach for friction modification between wheel and rail. The main goal of this study was to investigate potential risks and benefits associated with the application of these products, especially in terms of adhesion, wear, and noise. For this purpose, both laboratory and field experiments were carried out.
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Li, Yang, Renja Romey-Glüsing, Navid Tahan Zadeh, Jakob von Frieling, Julia Hoffmann, Patricia Huebbe, Iris Bruchhaus, Gerald Rimbach, Christine Fink und Thomas Roeder. „Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling“. Nutrients 12, Nr. 4 (22.04.2020): 1172. http://dx.doi.org/10.3390/nu12041172.
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Algal products are well known for their health promoting effects. Nonetheless, an in depth understanding of the underlying molecular mechanisms is still only fragmentary. Here, we show that aqueous furbelow extracts (brown algae, Saccorhiza polyschides) lengthen the life of both sexes of the fruit fly Drosophila melanogaster substantially, if used as nutritional additives to conventional food. This life prolonging effect became even more pronounced in the presence of stressors, such as high-fat dieting of living under drought conditions. Application of the extracts did not change food intake, excretion, or other major physiological parameters. Nevertheless, effects on the intestinal microbiota were observed, leading to an increased species richness, which is usually associated with healthy conditions. Lifespan extension was not observed in target of rapamycin (TOR)-deficient animals, implying that functional TOR signaling is necessary to unfold the positive effects of brown algae extract (BAE) on this important trait. The lack of life lengthening in animals with deregulated TOR signaling exclusively targeted to body fat showed that this major energy storage organ is instrumental for transmitting these effects. In addition, expression of Imaginal morphogenesis protein-Late 2 (Imp-L2), an effective inhibitor of insulin signaling implies that BAE exerts their positive effects through interaction with the tightly interwoven TOR- and insulin-signaling systems, although insulin levels were not directly affected by this intervention.
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Yoon, Sang Sun, und John J. Mekalanos. „2,3-Butanediol Synthesis and the Emergence of the Vibrio cholerae El Tor Biotype“. Infection and Immunity 74, Nr. 12 (02.10.2006): 6547–56. http://dx.doi.org/10.1128/iai.00695-06.
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ABSTRACT Vibrio cholerae is an aquatic bacterium that causes the severe diarrheal disease cholera. V. cholerae strains of the O1 serogroup exist as two biotypes, classical and El Tor. Toxigenic strains of the El Tor biotype emerged to cause the seventh pandemic of cholera in 1961 and subsequently displaced strains of the classical biotype both in the environment and as a cause of cholera within a decade. The factors that drove emergence of the El Tor biotype and the displacement of the classical biotype are unknown. Here, we show a unique difference in carbohydrate metabolism between these two biotypes. When grown with added carbohydrates, classical biotype strains generated a sharp decrease in medium pH, resulting in loss of viability. However, growth of El Tor biotype strain N16961 was enhanced due to its ability to produce 2,3-butanediol, a neutral fermentation end product, and suppress the accumulation of organic acids. An N16961 mutant (SSY01) defective in 2,3-butanediol synthesis showed the same defect in growth that classical biotype strains show in media rich in carbohydrates. Importantly, the SSY01 mutant was attenuated in its ability to colonize the intestines of infant mice, suggesting that host carbohydrates may be available to V. cholerae within the intestinal environment. Similarly, the SSY01 mutant failed to develop biofilms when utilizing N-acetyl-d-glucosamine as a carbon source. Because growth on N-acetyl-d-glucosamine likely reflects the ability of a strain to grow on chitin in certain aquatic environments, we conclude that the strains of classical biotype are likely defective compared to those of El Tor in growth in any environmental niche that is rich in chitin and/or other metabolizable carbohydrates. We propose that the ability to metabolize sugars without production of acid by-products might account for the improved evolutionary fitness of the V. cholerae El Tor biotype compared to that of the classical biotype both as a global cause of cholera and as an environmental organism.
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Huneke, Craig, und Roger Wiegand. „Correction to “Tensor products of modules and the rigidity of Tor”, Math. Annalen, 299 (1994), 449–476“. Mathematische Annalen 338, Nr. 2 (10.01.2007): 291–93. http://dx.doi.org/10.1007/s00208-006-0076-9.
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Tomčová, Renata. „Testování výkonnosti maziv pro kolejovou dopravu“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-443211.
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Top-of- rail lubricants are an effective way to control adhesion, reduce contact wear and noise in rail transport. However, despite the widespread use of these lubricants, there is currently no standard defining how to test and evaluate their performance. This work aims to develop a methodology for testing top-of-rail lubricants in a laboratory environment using a tribometer in a ball-on-disk configuration. At first, important operational parameters of experiments are analyzed and experimentally tested. These are mainly wear-in and run-in, method of application, roughness and geometric parameters of contact bodies. The result of this work is a testing methodology that guarantees good repeatability and reliability of results. In the last part of this work, the methodology is verified using commercial top-of-rail lubricants.
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Häßler, Alina, und Bernd Souren. „Which product attributes lead consumers to prefer startups’ products over established companies’ products in the specialty product category? : A study of the electric vehicle market in Germany“. Thesis, Högskolan Dalarna, Företagsekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:du-28013.
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Purpose – The purpose of this study is to investigate which product attributes lead consumers to prefer startups’ products over established companies’ products in the specialty product category. The research object is the electric vehicle market in Germany and the product attributes that are researched are alignable attributes, non-alignable attributes and the price. Design/Methodology/Approach – Quantitative data was collected via an internet questionnaire by means of the non-probability sampling techniques convenience and snowball sampling. The data of 408 members of the German Generation Y (age 17 – 38) was used to test six hypotheses by applying ANOVA and multiple linear regression analysis. Findings – It was found that established companies possess a pioneer advantage in comparison to startups for the specialty product ‘electric vehicle’. This advantage can be overcome when startups differentiate their electric vehicles by implementing superior alignable attributes, a valuable non-alignable attribute or a lower price. Superior alignable attributes had the strongest positive influence on consumers’ preferences towards the startup’s electric vehicle, followed by the lower price and a valuable non-alignable attribute. Limitations/Implications – This study is limited to investigating consumers’ preferences without focusing on the reasons behind the preferences. Further, the category of specialty products is represented by only one example, namely the electric vehicle industry. Practical Implications – Startups can benefit from the results by adopting differentiation strategies that were found to be successful in overcoming pioneer advantage. Originality/Value – This study contributes to pioneer advantage literature by researching how startups can successfully overcome pioneer advantage in the specialty product category.
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Tomaz, Paulo Roberto Ussoni [UNESP]. „Desenvolvimento e validação de método de análise por cromatografia gasosa para metabólitos polares de folhas de cana-de-açúcar e aplicação na avaliação da influência do teor de 'CO IND. 2' atmosférico na composição de metabólitos polares de cana-de-açucar“. Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/97985.
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tomaz_pru_me_araiq.pdf: 2095280 bytes, checksum: a9ae721a6f65278be5cc8092684ebc58 (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Metabolômica é uma abordagem promissora para o estudo global dos processos ecofisilógicos, monitorando através de técnicas analíticas de alto desempenho o maior número possível de metabólitos micromoleculares de vários órgãos e tecidos de um organismo. Poucos estudos metabolômicos foram desenvolvidos com cana-de-açúcar (Saccharum spp), especialmente no Brasil. Nessa abordagem é de suma importância o desenvolvimento e/ou implantação de métodos analíticos robustos para o estudo de ampla gama de metabólitos de um organismo, tanto primários quanto secundários, e sua aplicação no sentido de contribuir para o entendimento a nível molecular dos processos ecofisiológicos desse vegetal. Neste trabalho foi feita a otimização das condições de extração e cromatográficas por CG-FID para análise de metabólitos polares em folhas. Para tal foi utilizado o cultivar RB3280. Posterior à sua implantação, o método foi utilizado para análise do perfil metabólico de folhas de cana-de-açúcar, durante seu crescimento, em condições climáticas simuladas de alta concentração de CO2 (720 ppm). O método desenvolvido consiste na extração de folhas de cana-de-açúcar com água contendo ribitol como padrão interno, derivação através de metoximação e trimetilsililação e subseqüente análise por GC-FID utilizando coluna DB-05 e programação de temperatura de 70° C a 290° C, a uma taxa de incremeto de 5o C.min-1. Nessas condições é possível observar cerca de 200 picos cromatográficos. A identificação dos constituintes da amostra através da comparação de índices de retenção, espectros de massas (GC-MS) e busca em bancos metabolômicos disponíveis on line, culminou na identificação de 50 substâncias. No experimento de cultivo sob condição atmosférica controlada foi verificado tendência de aumento de monossacarídeos...
Metabolomics is a promising approach to the study of global ecofisilogics, monitoring through high-performance analytical techniques as many small molecules for metabolites of various organs and tissues of an organism. Few studies have been developed metabolomics with sugar cane (Saccharum spp), especially in Brazil. This approach is of paramount importance to develop and / or deployment of robust analytical methods for studying a wide range of metabolites in an organism, both primary and secondary, and their application in order to contribute to the understanding of the processes at the molecular level of ecophysiological plant. This work was made master of the optimization of extraction and chromatographic conditions for GC-FID for analysis of polar metabolites in leaves. For this was used to cultivate RB3280. After its implementation, the method was used to analyze the metabolic profiles of leaves of sugar cane during its growth in simulated climatic conditions of high CO2 concentration (720 ppm). The method consists of extracting the leaves of cane sugar with water containing Ribitol as internal standard, and lead through metoximation trimetilsililation and subsequent analysis by GC-FID using DB- 5 column and temperature programming from 70 ° C to 290 ° C at a rate of 5 ° C min - 1 increase. Under these conditions it is possible to observe approximately 200 chromatographic peaks. The identification of the sample by comparing retention indices, mass spectra (GC-MS) metabolomics and search available online banks, resulted in the identification of 50 substances. In the experiment of cultivation under controlled atmospheric conditions was observed increasing trend of monosaccharides in plants grown under 750 ppm CO2, and a decrease of constituent not identified yet
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Felekoğlu, Burcu. „Top management involvement in new product development projects“. Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610097.
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Tomaz, Paulo Roberto Ussoni. „Desenvolvimento e validação de método de análise por cromatografia gasosa para metabólitos polares de folhas de cana-de-açúcar e aplicação na avaliação da influência do teor de 'CO IND. 2' atmosférico na composição de metabólitos polares de cana-de-açucar /“. Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/97985.
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Orientador: Alberto José CavalheiroBanca: Antônio Eduardo Miller Crotti
Banca: Renata Colombo
Resumo: Metabolômica é uma abordagem promissora para o estudo global dos processos ecofisilógicos, monitorando através de técnicas analíticas de alto desempenho o maior número possível de metabólitos micromoleculares de vários órgãos e tecidos de um organismo. Poucos estudos metabolômicos foram desenvolvidos com cana-de-açúcar (Saccharum spp), especialmente no Brasil. Nessa abordagem é de suma importância o desenvolvimento e/ou implantação de métodos analíticos robustos para o estudo de ampla gama de metabólitos de um organismo, tanto primários quanto secundários, e sua aplicação no sentido de contribuir para o entendimento a nível molecular dos processos ecofisiológicos desse vegetal. Neste trabalho foi feita a otimização das condições de extração e cromatográficas por CG-FID para análise de metabólitos polares em folhas. Para tal foi utilizado o cultivar RB3280. Posterior à sua implantação, o método foi utilizado para análise do perfil metabólico de folhas de cana-de-açúcar, durante seu crescimento, em condições climáticas simuladas de alta concentração de CO2 (720 ppm). O método desenvolvido consiste na extração de folhas de cana-de-açúcar com água contendo ribitol como padrão interno, derivação através de metoximação e trimetilsililação e subseqüente análise por GC-FID utilizando coluna DB-05 e programação de temperatura de 70° C a 290° C, a uma taxa de incremeto de 5o C.min-1. Nessas condições é possível observar cerca de 200 picos cromatográficos. A identificação dos constituintes da amostra através da comparação de índices de retenção, espectros de massas (GC-MS) e busca em bancos metabolômicos disponíveis on line, culminou na identificação de 50 substâncias. No experimento de cultivo sob condição atmosférica controlada foi verificado tendência de aumento de monossacarídeos... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Metabolomics is a promising approach to the study of global ecofisilogics, monitoring through high-performance analytical techniques as many small molecules for metabolites of various organs and tissues of an organism. Few studies have been developed metabolomics with sugar cane (Saccharum spp), especially in Brazil. This approach is of paramount importance to develop and / or deployment of robust analytical methods for studying a wide range of metabolites in an organism, both primary and secondary, and their application in order to contribute to the understanding of the processes at the molecular level of ecophysiological plant. This work was made master of the optimization of extraction and chromatographic conditions for GC-FID for analysis of polar metabolites in leaves. For this was used to cultivate RB3280. After its implementation, the method was used to analyze the metabolic profiles of leaves of sugar cane during its growth in simulated climatic conditions of high CO2 concentration (720 ppm). The method consists of extracting the leaves of cane sugar with water containing Ribitol as internal standard, and lead through metoximation trimetilsililation and subsequent analysis by GC-FID using DB- 5 column and temperature programming from 70 ° C to 290 ° C at a rate of 5 ° C min - 1 increase. Under these conditions it is possible to observe approximately 200 chromatographic peaks. The identification of the sample by comparing retention indices, mass spectra (GC-MS) metabolomics and search available online banks, resulted in the identification of 50 substances. In the experiment of cultivation under controlled atmospheric conditions was observed increasing trend of monosaccharides in plants grown under 750 ppm CO2, and a decrease of constituent not identified yet
Mestre
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Gouvêa, Vinicius Nunes de. „Caroço de algodão em dietas contendo alto teor de concentrado para bovinos Nelore terminados em confinamento“. Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-30032016-105029/.
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Esse trabalho foi conduzido com o objetivo de avaliar os efeitos da inclusão de óleo de soja ou de teores de caroço de algodão (CA) em dietas contendo alto teor de concentrado para bovinos confinados. No experimento I foram utilizados seis bovinos machos, castrados, da raça Nelore (407 ± 24 kg de peso corporal), distribuídos em um delineamento em Quadrado Latino 6 x 6. Foram avaliados 5 teores de inclusão (0, 8, 16, 24 e 32%) de CA em dietas contendo 80% de concentrado (tratamentos CA0, CA8, CA16, CA24 e CA32, respectivamente). Além disso, foi avaliada uma dieta contendo o mesmo teor de lipídios totais da dieta CA32, porém sem a inclusão de caroço de algodão, utilizando óleo de soja (tratamento OS). A inclusão de caroço de algodão na dieta reduziu (efeito linear, P < 0,01) o consumo de matéria seca e o consumo de matéria orgânica dos animais. A digestibilidade aparente total da MS (P = 0,019) e da MO (P = 0,020) reduziu linearmente devido à inclusão de CA na dieta dos animais. A inclusão de óleo de soja na dieta não afetou o digestibilidade da MS (P = 0,462) e da MO (P = 0,469) dos animais em comparação aos animais alimentados com a dieta controle, sem CA, assim como também não foram observados efeito da fonte de lipídios sobre a digestibilidade da MS (P = 0,124) e da MO (P = 0,110). O tempo de ruminação aumentou linearmente (P = 0,002) em resposta a inclusão de CA. O pH ruminal dos animais aumentou (efeito quadrático, P < 0,05) em resposta à inclusão de caroço de algodão nas dietas. O inclusão de óleo de soja na dieta não afetou (P = 0,329) o pH ruminal dos animais em comparação com a dieta controle sem CA. A produção total de ácidos graxos de cadeia curta reduziu (P < 0,001; efeito linear) devido à inclusão de CA. A síntese de Pmic reduziu linearmente (P = 0,011) em resposta a inclusão de CA na dieta. No experimento II, foram utilizados 280 bovinos machos, da raça Nelore e peso médio inicial de 349 ± 33 kg, distribuídos em 40 baias. O delineamento utilizado foi blocos incompletos casualizados. O máximo peso final foi obtido com inclusões de 7,6% de CA. A inclusão de CA na dieta reduziu o CMS dos animais (P < 0,001). A inclusão de óleo de soja reduziu o CMS dos animais (P < 0,05) em comparação com os animais alimentados com a dieta controle sem caroço de algodão. O máximo GPD foi observado com 8% de inclusão de CA na dieta. A máxima EA ocorreu com 14,5% de CA na dieta. Os dados referentes as característica da carcaça (PQC, RC, AOL e EGS) também apresentaram resposta quadrática (P < 0,05) à inclusão de CA na dieta. Comparado ao tratamento controle, sem CA na dieta, a inclusão de óleo de soja não afetou nenhuma das características da carcaça avaliadas (P > 0,05). As características químicas da carne não diferiram (P > 0,05) entre os animais alimentados com dietas contendo 32% de CA daqueles alimentados com óleo de soja. A oxidação dos lipídios (TBARS) apresentou redução (efeito quadrático; P = 0,035) devido à inclusão de CA na dieta. Na avaliação sensorial da carne assada realizada através do painel consumidor, não foram observados efeitos dos tratamentos sobre o sabor, odor e aceitabilidade geral da carne (P > 0,05). Na avaliação das características organolépticas da carne realizada pelos provadores treinados também não foram observados efeitos dos tratamentos sobre o odor, sabor e aceitabilidade geral (P > 0,05). No experimento III, avaliou-se a cinética de fermentação ruminal do milho e do caroço de algodão através da produção cumulativa de gases. Foram utilizados cinco frascos (repetições) contendo 1g de substrato (milho ou CA) além de 5 frascos “brancos” (sem substrato). As leituras de pressão e volume dos gases acumulados nos frascos de incubação foram realizadas com transdutor de pressão nos tempos 0, 2, 4, 6, 8, 10, 12, 15, 19, 24, 30, 36, 48, 72 e 96 horas. O milho apresentou um maior potencial de produção de gases quando comparado ao caroço de algodão (P < 0,001). O tempo de colonização não apresentou diferença entre as duas fontes de energia (P = 0,646). O caroço de algodão apresentou uma maior taxa de degradação comparado com o milho (P = 0,001) e, consequentemente, para a redução (P < 0,001) do tempo necessário para atingir a máxima produção de gás. O milho apresentou uma maior potencial de degradação quando comparado com o caroço de algodão, resultado esse que pode ser observado pelo maior produção de gases. Apesar não suportar um grande potencial de degradação, parte da fração fribrosa do caroço de algodão apresentou alta degradabilidade, o que pode ser observado na sua maior taxa de degradação quando comparado com o milhoThree trials were conducted to evaluate the effects of the inclusion of levels of whole cottonseed (WC) or soybean oil (SO) in diets for Nellore feedlot cattle. In the experiment I six rumen-cannulated Nellore steers (407 ± 24 kg BW) were used in a 6 x 6 Latin square design experiment. Were evaluated 5 levels of inclusion of WC (0, 8, 16, 24 and 32% DM basis) in diets containing 87% concentrate (treatments WC0, WC 8, WC16, WC24 and WC32 respectively). Also, it was evaluated a diet containing the same amount of total fat content of WC32 but with no WC and using soybean oil (SO treatment). Increasing WC levels linearly decreased DM and OM intake (P < 0.01). CP and NDF intakes were not affected by the treatments. Total fat digestibility linearly increased due the WC increase in the diets (P < 0.001). Total DM (P = 0.019) and OM (P = 0.020) digestibilities linearly decreased with increasing levels of WC. SO inclusion did not affect DM (P = 0.462) and OM (P = 0,469) digestibilities compared with CA0 and there was no effect of fat source over DM (P = 0.124) and OM (P = 0.110) digestibilities. Rumination time linearly increased due the WC inclusion (P = 0,002). Increasing WC levels quadratically increased ruminal pH (P < 0.05) but no effect was observed with the SO addiction in the diet (P = 0.329) compared with CA0. Total VFA was linearly decreased with increasing levels of WC (P < 0.001). Increasing levels of WC linearly decreased the microbial protein synthesis (P = 0.011). In the experiment II a total of 280 Nellore bulls (initial BW = 349 ± 33 kg) were allotted in 40 pens. The statistical design was randomized incomplete blocks. The maximum final BW was obtained with 7.6% of inclusion of WC. Increasing levels of WC decreased DMI (P < 0.001). Adding SO also decreased DMI (P < 0.05) compared with WC0. Increasing the inclusion rate of WC quadractically increased the ADG, G:F, HCW, dressing percent, LM area and 12-rib fat (P < 0.05). The maximum ADG were obtained with 8% of inclusion of WC. On the other hand, the maximum G:F was obtained with 14.5% of WC. Compared with WC0, the SO inclusion did not affect carcass characteristics (P > 0.05). The inclusion of WC quadractically affect meat composition (P < 0.05). Compared with CA32, the inclusion of SO in the diet did not affect the meat composition. Increasing WC in the diets quadratically decrease (P = 0.035) lipid oxidation. No effects were observed in the sensorial evaluation flavor, taste and overall acceptability by the costumers (P > 0.05). Training sensory panelists also did not find differences between the treatments for flavor and taste. Increasing WC linearly decreased the tenderness (P = 0.045). Compared with CA32, the inclusion of SO increased meat tenderness (P = 0.031). In the experiment III was evaluated the ruminal fermentation kinetics of corn and cottonseed through the in vitro gas production technique. Five bottles for each energy source (corn and cottonseed), plus five additional bottles containing buffered medium and rumen fluid inoculum only (blanks) were used. The volume of gas produced was recorded at 0, 2, 4, 6, 8, 10, 12, 15, 19, 24, 30, 36, 48, 72 e 96 h of incubation using the pressure reading technique. Gas values were corrected for blank incubations. The corn had greater gas production than cottonseed (P < 0.001). Lag time was not different between the two energy sources (P = 0.646). Cottonseed had higher FDR than corn (P = 0.001) and shorter time to half asymptote (P < 0.001). Corn had higher potential of degradation compared with cottonseed observed by the higher gas production. Moreover, even with lower potential of degradation, the cottonseed fibrous fraction had a high degradability compared to corn
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Shibao, Julianna. „Avaliação do teor de produtos da reação de Maillard (PRM) em cereais matinais e café“. Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/6/6138/tde-13072010-102913/.
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INTRODUÇÃO Produtos intermediários da reação de Maillard e da peroxidação, como os compostos dicarbonílicos, reagem facilmente com grupamentos aminas de proteínas e ácidos nucléicos levando a modificações biológicas que podem resultar em patologias observadas no diabetes, aterosclerose e doenças neurodegenerativas. O consumo de Produtos da Reação de Maillard (PRM) aumentou nas últimas décadas e há evidências de que estas substâncias são absorvidas e podem tomar parte em processos patológicos, embora ainda não haja consenso sobre os possíveis efeitos deletério à saúde a partir do aumento de sua ingestão. Ressalta-se a necessidade de estimar o consumo destes PRMs a partir de dados sobre os conteúdos e a ingestão habitual do alimento em questão como cereais matinais e café. Objetivos: a) validar metodologia para quantificar indicadores da reação de Maillard: hidroximetilfurfural (HMF), furosina (FUR), carboximetilisina (CML) e Compostos Intermediários Fluorescentes (CIF) em cereais matinais (flocos e granola) e café; b) avaliar se há diferenças nos teores desses compostos nas diferentes marcas destes produtos comercializados em São Paulo; METODOLOGIA: Foram analisados dois lotes de três marcas de cereais do tipo flocos, três marcas de cereais do tipo granola e cinco marcas de café presentes em 100 por cento dos hipermercados visitados no município de São Paulo. A validação da metodologia para quantificação, empregando HPLC, consistiu no cálculo da exatidão (recuperação), repetibilidade e sensibilidade para os compostos: HMF e FUR. Foram determinados os teores de CIF por espectrofotometria de fluorescência e os teores de CML por teste imunoenzimático. RESULTADOS: Os métodos de determinação de FUR e HMF foram validados conforme o Instituto Nacional de Metrologia, Normalização e 9 Qualidade Industrial (INMETRO). O teor médio de CIF livre e total foram maiores para as amostras de café, com média de 232CIF/mg e 765CIF/mg respectivamente. Não houve diferença (p>0,05) no teor de CIF livre e total entre os flocos F1 e F2. O mesmo foi observado para a granola marcas. G1, G2 e G3 A granola foi o produto com maior teor médio de HMF (67,5mg/Kg) e furosina (301mg/100g de proteína). A FUR não foi detectado nas amostras de café. Todas as marcas dos alimentos estudados para os indicadores HMF e FUR apresentaram diferença estatisticamente significativa (p<0,05). O café apresentou maior teor médio de CML (1823,5ng/mg de proteína), sem diferença entre as marcas (p>0,05) CONCLUSÕES: Os cereais do tipo flocos contribuem para maior ingestão de PRMs da fase inicial da reação de Maillard (RM), a granola contribui para maior ingestão de PRMs da fase intermediária da RM e o café contribui de forma significativa para maior ingestão de PRMs da fase avançada da RM. O café, por ser submetido a tratamento térmico mais severo apresenta maior concentração de PRMs da fase avançada da reaçãoINTRODUCTION Maillard reaction products and lipid peroxidation, such as dicarbonyl compounds easily react with amino groups of proteins and nucleic acids leading to biological changes that can result in complications in diseases such as diabetes, atherosclerosis and neurodegenerative. The consumption of Maillard Reaction Products (MRP) has increased in recent decades and there is evidence that these substances are absorbed and can participate in pathological processes, although there is no consensus about the possible harmful health effects from their intake. We highlight the need to identify the consumption of MRP, mainly in vulnerable populations like children and diabetics, in order to establish acceptable daily intakes and guidelines for the food industry. OBJECTIVES: a) validate the methodology to measure indicators of the Maillard reaction: hydroxymethylfurfural (HMF), Furosine (RUF) carboxymethylysine (CML) and fluorescent intermediate compounds (FIC) in breakfast cereals (corn flakes and granola) and coffee, b) to evaluate if there are differences in the levels of these compounds contents among brands commercialized in São Paulo METHODS: two lots of 3 brands of flakes cereal, 3 brands of granola and 5 coffee brands present in 100 per cent of supermarkets visited in the city Sao Paulo were analyzed. HPLC methodology validation was assessed by determining accuracy (recovery), repeatability, and sensibility (linearity, limits of detection and quantitation) for the compounds: HMF and FUR. The contents of the Fluorescent Intermediary compounds (FIC) was measured by spectrophotometric method and the levels of CML by ELISA. RESULTS: Calibration curves determination coefficient (r 2) were higher than 0,99 for all compounds. Recovery ranged from 84 to 110 per cent and repeatability average was 3,5 per cent. The average content of free and total FIC was higher for coffee 232CIF/mg and 765CIF/mg respectively. The brands of granola and flakes was similar but just brands F1 and F2 was similar between brands (p<0,05). For HMF the higher values were for granola 67,5mg/kg. The presence of dried fruit in these grains may 11 have contributed significantly to the higher rate of this indicator. For indicator FUR average was higher in granola samples (301mg/100g of protein) and it was not possible to quantify the levels of FUR for coffee. All brands analyzed for HMF and FUR was similar (p<0,05). CML average was higher for coffee (1823,5ng/mg of protein). The brands analyzed was similar for all samples (p <0.05). CONCLUSIONS: Flakes contribute to higher intake of MRPs from early stage of the Maillard reaction (MR), the granola contributes to higher intake of MRPs from intermediate phase of MR and coffee contributes significantly to higher intake of final MRPs. Data suggest that coffee has more severe thermal treatment causing a higher concentration of MRPs from the final phase of the MR
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Nyman, Oscar. „Towards a quality control for cloud top pressure and cloud top height products“. Thesis, Luleå tekniska universitet, Institutionen för system- och rymdteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-61977.
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Cloud top height plays an important roll in the energy budget and is also important for aviation. This thesis concerns the quality control of cloud top height (CTH) retrievals. The approach for quality controlling retrieved CTH has been using the forward simulating software RTTOV. An error estimation function has been developed as well as an investigation to what simplifications can be done regarding the forward simulations for CTH purposes at SMHI. The purpose of the error estimation function is to validate CTH output from CTH retrieval algorithms by giving a rough error estimate of the retrieved CTH compared to what forward simulations predict. For simplifying the forward simulations the most promising results have been shown for lower clouds. Further testing is still of interest and for future work suggestions are provided regarding the error estimation function as well as for simplifying the forward simulations.
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Sartori, Sergio Birello. „Potencial metabólico de fungos endofíticos de plantas do gênero Anthurium da Ilha de Alcatrazes“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/11/11138/tde-29112016-141525/.
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Fungos endofíticos estão presentes em plantas de diversos ambientes e produzem compostos com amplas propriedades químicas e aplicações, tanto na área médico-farmacológica quanto na agronômica. Entretanto, ainda há muito a ser investigado sobre seu potencial biotecnológico, principalmente em locais pouco explorados. As ilhas apresentam um ambiente particular e altamente vulnerável, tornando-as locais promissores na busca de organismos pouco comuns ou ainda endêmicos. Sendo assim, neste trabalho foi realizado o isolamento e estudo químico e biológico de fungos endofíticos isolados de 2 espécies plantas do gênero Anthurium da Ilha de Alcatrazes-SP. Para isto, fragmentos foliares das plantas A. loefgrenii (HRCB 46467) e A. alctrazense (HRCB 46465 - endêmica da ilha) foram inoculados em 10 meios de cultivo com diferentes composições, resultando no isolamento de 106 fungos endofíticos. Por meio de análises químicas por MALDI-TOF-MS e ensaio biológico contra fitopatógenos, foram selecionados 3 fungos para estudo. Estes foram identificados por técnicas morfológicas e moleculares como sendo Penicillium citrinum (P2MSF2F3), Penicillium simplicissimum (P210-4F2) e Aureobasidium melanogenum (P7AF2F3). No estudo dos metabólitos secundários de P. citrinum foi isolado o composto citrinina, o qual apresentou atividade inibitória do crescimento micelial dos fitopatógenos Colletotrichum gloeosporioides (MIC= 125 μg mL-1), Colletotrichum lindemuthianum (MIC= 0,48 μg mL-1), Phomopsis sojae (MIC= 250 μg mL-1) e Fusarium oxysporum f. sp. phaseoli (MIC= 125 μg mL-1). Outras frações obtidas do meio metabólico de P. citrinum (fração F3a3 e citrinina) apresentaram atividade inibitória (100% de inibição) à formas promastigotas de Leishmania infantum. No estudo dos metabólitos secundários de P. simplicissimum foi obtida a fração F2b, ativa contra L. infantum (100% de inibição), da qual foram isolados os compostos andrastina A e penicisoquinolina, sendo o primeiro relato de sua produção por esta espécie, além de outros 5 compostos ainda não identificados. No estudo dos metabólitos secundários de A. melanogenum foi isolado o composto metil-orselinato, relatado pela primeira vez para este fungo. Do mesmo fungo foi obtida a fração F1d2l ativa contra L. infantum (100% inibição), da qual foram isolados 2 compostos ainda não identificados. Este é o primeiro relato de fungos isolados de antúrios da ilha de Alcatrazes, bem como do estudo de seus metabólitos secundários. Este trabalho apresenta contribuição no conhecimento sobre fungos endofíticos e seu potencial metabólico, com aplicações nas áreas agronômica e médico-farmacológica.Endophytic fungi are present in plants in various environments and produce compounds with wide chemical properties and applications, both in the medical and in agronomic field. However, much remains to be investigated about their biotechnological potential, especially in unexplored places. Islands have a particular and highly vulnerable environment, making them promising sites in search of unusual or endemic organisms. Thus, this work represents the isolation and chemical and biological study of endophytic fungi isolated from 2 species of plants of the genus Anthurium of Alcatrazes island-SP. For this, leaf fragments from plants A. loefgrenii (HRCB 46467) and A. alcatrazense (HRCB 46465 - endemic plant from the Island) were inoculated onto 10 culture media with different composition, resulting in the isolation of 106 endophytic fungi. Three strains were selected to be studied through chemical analysis by MALDI-TOF-MS and bioassay against phytopathogens. These were identified by morphological and molecular techniques as Penicillium citrinum (P2MSF2F3), Penicillium simplicissimum (P210-4F2) and Aureobasidium melanogenum (P7AF2F3). In the study of secondary metabolites of P. citrinum it was isolated the compound citrinin, which showed inibitory activity against the plant pathogens Colletotrichum gloeosporioides (MIC= 125 μg mL-1), Colletotrichum lindemuthianum (MIC= 0.48 μg mL-1), Phomopsis sojae (MIC= 250 μg mL-1) and Fusarium oxysporum f. sp. phaseoli (MIC= 125 μg mL-1). Other fraction obtained from the metabolic extract of P. citrinum (F3a3 fraction and citrinin), showed inibitory activity (100% inibition) to Leishmania infantum promastigotes. In the study of secondary metabolites of P. simplicissimum it was obtained F2b fraction, active against L. infantum (100% inhibition), which were isolated andrastin A and penicisoquinoline compounds, the first report of its production for this species, as well 5 unidentified compounds. In the study of secondary metabolites from A. melanogenum was isolated the methyl-orsellinate compound, first reported for this fungus. From the same strain was obtained F1d2l fraction, active against L. infantum (100% inhibition), from which were isolated 2 unidentified compounds. This is the first report of fungi isolated from Alcatrazes Island anthuriums and the study of their secondary metabolites. This study presents contribution to knowledge of endophytic fungi and their metabolic potential with applications in the medical and agronomic fields.
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Piovani, Laura. „Study of low environmental coating products: bio-based water products and solvent based products deriving from PET recycling“. Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
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In this study three different projects are presented.The first consist in the analysis of two different bio resins with which a white and a transparent water-based base coat, a transparent water-based top coat and a water-based hydro-oil are formulated, applied and characterized, replacing the fossil based resins. First, the two bio resins are analyzed in terms of compatibility with other resins, additives and solvents and then the products formulated are characterized in terms of viscosity and chemical resistances. After the application, the products are analyzed in terms of filming capacity. The second project consists in formulating a coating system using the bio resin, suitable for use on bamboo toothbrushes in order to avoid the formation of mold. In particular two different formulations with two different viscosities are tested after having subjected the toothbrush to different pre-treatments based on H2O2 30 volumes, saturated solution of AgNO3. The third project consists in the formulation of two solvent-based clear coating systems: a base coat with a matte top coat and a base coat with a glossy top coat. For both systems an alkyd resin is used, whose fatty acid part consists of olive fatty acids, containing 12-14% recycled PET. The two system are formulated, applied and characterized in terms of viscosity, specific weight, transparency, elasticity, sand ability and chemical resistances. A comparison is made with the same products produced using the fossil based resins.The results show that the products formulated using the bio resins have similar characteristics of the standard resins therefore the bio products can replace the fossil based one. The toothbrushes coated with the coating system using the two new formulations are more resistant to the formation of mold. Finally, the two solvent-based coating system formulated using a resin containing PET can replace a coating system formulated with fossil based resin as they present similar characteristics.
Bücher zum Thema "TOR products"
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Brodbeck, Didier. Chic et toc: Le vrai livre des contrefaçons. Paris: Balland, 1990.
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Top producer. Waterville, Me: Thorndike Press/Gale, 2009.
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Vonnegut, Norb. Top producer. Waterville, Me: Thorndike Press/Gale, 2009.
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Vonnegut, Norb. Top producer. Waterville, Me: Thorndike Press, 2009.
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Hollender, Barbara. Zespół "TOR". Warszawa: Prószyński i S-ka, 2000.
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Stansfield, Edgar. Products and by-products of coal. Ottawa: Govt. Print. Bureau, 1997.
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Fortis, Marco, Stefano Corradini und Monica Carminati. Italy’s Top Products in World Trade. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15817-4.
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Winsor, John. Flipped: How bottom-up co-creation is replacing top-down innovation. Chicago: B2 Books, 2010.
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1959-, Winsor John, Hrsg. Flipped: How bottom-up co-creation is replacing top-down innovation. Chicago: B2 Books, 2010.
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The lean machine: How Harley-Davidson drove top-line growth and profitability with revolutionary lean product development. New York: American Management Association, 2010.
Den vollen Inhalt der Quelle findenBuchteile zum Thema "TOR products"
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Rubin, Julia, und Marsha Chechik. „Combining Related Products into Product Lines“. In Fundamental Approaches to Software Engineering, 285–300. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28872-2_20.
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Alford, B. W. E. „Industry: Too few Producers?“ In British Economic Performance, 1945–1975, 34–51. London: Macmillan Education UK, 1988. http://dx.doi.org/10.1007/978-1-349-08163-9_3.
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Rahikkala, Jurka, Sami Hyrynsalmi, Ville Leppänen, Tommi Mikkonen und Johannes Holvitie. „Top Management Support for Software Cost Estimation“. In Product-Focused Software Process Improvement, 89–107. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-69926-4_8.
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Affleck, James G. „What Top Management Expects from Commercial Development“. In Successful Product and Business Development, 207–16. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003209935-15.
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Givant, Steven. „Direct products“. In Introduction to Relation Algebras, 419–98. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65235-1_11.
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Givant, Steven. „Subdirect products“. In Introduction to Relation Algebras, 499–518. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65235-1_12.
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Fioresi, Rita, und Marta Morigi. „Scalar Products“. In Introduction to Linear Algebra, 177–92. Boca Raton: Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9781003119609-10.
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Lacy, Peter, und Jakob Rutqvist. „The Product Life-Extension Business Model: Products that Are Built to Last“. In Waste to Wealth, 68–83. London: Palgrave Macmillan UK, 2015. http://dx.doi.org/10.1057/9781137530707_6.
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Agarwal, Ravi P., Kanishka Perera und Sandra Pinelas. „Infinite Products“. In An Introduction to Complex Analysis, 281–86. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0195-7_42.
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Berhuy, Grégory, und Frédérique Oggier. „Crossed products“. In An Introduction to Central Simple Algebras and Their Applications to Wireless Communication, 101–27. Providence, Rhode Island: American Mathematical Society, 2013. http://dx.doi.org/10.1090/surv/191/07.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "TOR products"
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Fukuda, Shuichi. „Personal Modular Design“. In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51199.
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This is a position paper. Although modular design is getting wide attention these days, most of the discussions and applications are focused on efficiency, cost reduction, etc., which has been regarded important in the traditional product development or in the producer’s framework. Their focus is how they can prepare wider variety with less time, money and energy. They believe if a wide variety of products are offered. the customer would select the one that would fit them best. Thus, not too much attention is paid to the customer expectations. The current producer do not sell dreams. They just increases the choices. This can be compared to what animals are doing. Animals can use tools, but these tools are found in nature. Animals do not make tools, but humans do, because humans can see the future, while animals cannot. Engineering is an activity to satisfy customer dreams. In this sense, the current industry is not achieving what engineering is supposed to achieve. In addition, as human needs step up, humans would like to actualize themselves. But in the earlier or lower step, their needs are products so products satisfy them. But when they step more and more upward, they find value in the processes. So products alone will not satisfy them enough. They would like to make their dreams come true by themselves. Thus, how we can get customers involved in the production becomes important. In short, we have to consider how we can mix high tech and low tech and work them harmoniously. Some modules needs high tech. Thus expertise is needed. But others can be developed and produced by customers. Then, customers will be very happy because they are players in the game and they feel they themselves are developing a product to realize their own dream. Of course, personal fabrication technology can be used for this purpose. But theirs and my idea are basically different. Their idea is to produce a product by ourselves. But the approach proposed here is focused on our industrial products. The issue here is how we can bring our customers into our product development, which current industries are practicing. If we can design a product, which is composed of modules which needs high tech and expertise and those which can be produced with low tech, then we can bring our customers into low tech and low expertise module production. Although customers are not producing the whole product, they feel happier because they are now making their dream come true themselves. Thus, industries can sell processes. And it should be stressed that this is not a reconfigurable design. The low tech and low expertise modules are really produced by our customers. They do not select modules to produce a product as we do with Lego. This design of mixture of low tech module and high tech module serves for globalization as well. Some developing countries cannot produce high tech modules, because their resources are not enough. But if some modules can be produced with low tech, then they can produce them locally and that will increase employment and the market will expand.
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Coughlin, Michael K., und Michael J. Scott. „An Activity-Based Costing Method to Support Market-Driven Top-Down Product Family Design“. In ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/detc2013-12264.
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As more and more companies offer product families rather than individual products, the competitive advantage of product platforming is shrinking. In order to compete companies need to link marketing and engineering so that designers are able to make decisions about critical trade-offs between cost and performance. The current methods for market-driven platform designs use traditional product costing where indirect costs are assigned to individual products based on relative production quantities. Because of increasing product diversity and decreasing direct labor costs, the ratio of indirect costs to total cost of products is increasing. A method for use during the design stage of top-down product family design is needed to assign indirect costs to individual products based on the product’s consumption of indirect resources. An activity-based costing method for top-down product family design is presented here. This method allows the designer to model indirect costs as a function of engineering attributes, creating a framework for top-down product platform optimization that provides a more accurate estimation of cost than traditional product costing methods. An illustrative example shows that an activity-based costing model predicts different profitability from a traditional costing system for a number of different motor designs.
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Ramesh, Raghuram Puthali, und Shun Takai. „Top-Down Benchmarking Approach for Estimating Cost of Concept“. In ASME 2006 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/detc2006-99615.
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Due to the highly competitive nature of businesses today, cost estimation forms an important strategic process in making decisions about design and development of new products. The focus is on improving the quality and service of the product at ever reducing costs. In conceptual design phase, engineers need to estimate how much the final products developed from each concept may cost. Estimating cost of the final product is critical in selecting the optimal concept. Majority of the cost estimation techniques used in the industry today concentrate on the parametric estimation. Parametric estimation accurately predicts cost of the final product using historic data about cost drivers. However, if firms are developing new products different from their past product categories, historic data may not be a credible source for parametric cost estimation. In this paper, the authors proposed a top-down benchmarking approach in estimating cost of new products in conceptual design phase. The objective is to construct a cost distribution model for the final product developed from each concept.
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Zadbood, Amineh, Nicholas Russo und Steven Hoffenson. „Word-of-Mouth Recommendations in an Automobile Market System“. In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-97680.
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Abstract Improving design in the context of market systems requires an understanding of how consumers learn about and evaluate competing products. Marketing models frequently assume that consumers choose the product with the highest utility, which provides businesses insights into how to design and price their products to maximize profits. While recent research has shown the impacts of consumer interactions within social networks on their purchasing decisions, they typically model market systems using a top-down approach. This paper applies an agent-based modeling approach with social network models to investigate the extent to which word-of-mouth (WOM) communications are influential in changing consumer preferences and producer market performance. Using a random network, we study the effects of the number of referrals for a product and the degrees of similarity between the senders and receivers of referrals on purchase decisions. In addition, the eigenvector centrality metric is used to analyze the spread of WOM referrals. The simulation results show that the most influential consumers in the network can create significant shifts in the market share, and a statistical analysis reveals a significant change in the system-level metrics of interest for the competing firms when WOM recommendations are included. The findings incentivize producers to invest in supporting their product development efforts with rigorous social networks analysis so as to increase their market success.
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Georgiadis, Kostas, Giorgos Kordopatis-Zilos, Fotis Kalaganis, Panagiotis Migkotzidis, Elisavet Chatzilari, Valasia Panakidou, Kyriakos Pantouvakis et al. „Products-6K: A Large-Scale Groceries Product Recognition Dataset“. In PETRA '21: The 14th PErvasive Technologies Related to Assistive Environments Conference. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3453892.3453894.
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Eisenhard, Julie L., David R. Wallace, Ines Sousa, Mieke S. De Schepper und Jeroen P. Rombouts. „Approximate Life-Cycle Assessment in Conceptual Product Design“. In ASME 2000 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/detc2000/dfm-14026.
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Abstract Prior work has demonstrated the integration of detailed life-cycle assessment into a traditional design modeling process. While a full life-cycle assessment provides insight into a product’s potential impact on the environment, it is often too time consuming for analysis during conceptual product design, where ideas are numerous and information is scarce. The work presented in this paper explores an approximate method for preliminary life-cycle assessments without detailed modeling requirements. Learning algorithms trained on the known characteristics of existing products allow the environmental impacts of new products to be approximated quickly during conceptual design. Artificial neural networks train on product attributes and environmental impact data from pre-existing life-cycle assessment studies. The product design team queries the trained artificial model with new high-level product attribute data to quickly obtain an approximate impact assessment for a new product concept. Tests based on simplified inventory data have shown it is possible to predict impacts on life-cycle energy consumption, and that there is a basis for the method to be used in also predicting solid material, greenhouse effect, ozone layer depletion, acidification, eutrophication, winter smog, and summer smog.
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Wickham, N. W. R., G. M. Vercellotti, H. Q. Yin, H. S. Jacob und C. F. Moldow. „ENDOTHELIAL CELLS PRODUCE PLATELET ACTIVATING FACTOR WHICH PRIMES NEUTROPHILS TO RELEASE OXIDANT PRODUCTS“. In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642861.
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Thrombin (THR) is generated during ARDS, sepsis and DIC. We wondered whether it might augment PMN/endothelial cell (EC) interaction and hence amplify EC damage by inducing platelet activating factor (PAF) (JCI 76:2235-2246;1985). To examine further this premise and the mechanisms involved, we measured intracel1ular calcium (Ca1) in human EC (grown on glass cover slips), in a scanning spectrof1uorometer at 37°C after loading with FURA 2 (4μM). Resting Ca1 was 148±22 nM (Mean±SEM) which increased following THR 0.5u/ml to 458±160 nM at 30s, peaking after 1 min at 559±176 nM, and returning to 273±42 nM by 5 min. Phosphatidyl inositol (PI) turnover was assessed in 3H-myoinositol-loaded EC using water-soluble extracts separated by Dowex anion exchange chromatography. Within 30s of THR (lu/ml) stimulation, PI turnover markedly increased, with production of inositol bi- and tri-phosphates showing a >5 fold rise. Associated with these perturbations, THR-treated EC monolayers enhanced O2- generation by FMLP(10™7)-stimulated PMNs (basal levels of 5.73±0.68 O2-/15 min/106 PMN rising to 8.01±0.85 nM (p<0.05)); moreover this enhancement could be completely inhibited with a newly described PAF antagonist BN 52021. PAF production is dependent upon phosphorylation of an acetyl transferase, and Ca1 flux and PI hydrolysis are events known to be associated with protein kinase activation. THR-EC stimulation would seem, therefore, to initiate a sequence of events involving PMN/EC 'cross-talk' leading to contact activation of marginated PMNs by EC-derived PAF. This is an example of a novel paracrine response, and is consistent with our data showing the potent priming effect of PAF on PMN oxidant responses (Blood 68:88A; 1986) and provides evidence for a previously unsuspected pathway that promotes PMN oxidant-mediated EC injury during sepsis or other THR-generating disorders.
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Wu, Yizhong, Renbin Xiao, Yifang Zhong und Hanmin Shi. „A Study on Computer Aided Bionic Design System Based on Self-Organization of Modelons“. In ASME 2000 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/detc2000/dac-14521.
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Abstract All the design activities of new products are top-down processes, in turn, conceptual design, functional design, structural design and detailed design. Unfortunately, design activity under the most traditional CAD systems belongs to a bottom-up process that has many disadvantages such as low efficiency, difficulty of modification and limitation of original thoughts of designers. This paper will describe a new approach for product design, i.e., computer aided bionic design (CABD), integrating both top-down and bottom-up process, which imitates partible attribute of functional structure and self-organization mechanism of cells of organism. Bionic design includes constructing of modelons that constitute a product through computer aided conceptual design (CACD) and structural design, building of product’s local structural gene and global structural gene through self-organization planning of constraints, generating of modelons and automatic assembling of modelons based on the self-organization mechanism under the control of product structural gene. A prototype system based on this approach has been implemented and an example will be presented in this paper.
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Wan, Qian, Raymond Chi-Wing Wong und Yu Peng. „Finding top-k profitable products“. In 2011 IEEE International Conference on Data Engineering (ICDE 2011). IEEE, 2011. http://dx.doi.org/10.1109/icde.2011.5767895.
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Turner, Callaway, Scott Ferguson und Joseph Donndelinger. „Exploring Heterogeneity of Customer Preference to Balance Commonality and Market Coverage“. In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-48581.
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Offering increased variety in a market is one method of capturing greater market share. However, we generally observe diminishing marginal returns in share as the size of the product line is increased. Leveraging commonality is a means of offsetting this constraint as it leads to reductions in manufacturing costs and build complexity. Product platforms strive to capitalize on the naturally occurring phenomena that yield commonality in a product line. The structure of design variable values of individually optimized products create opportunities for commonality in a bottom-up platform, while a top-down platform discovers opportunities for commonality through similarity in customer preferences. This paper explores the effect of changing the number of products, and commonality between those products, on market share. Results from designing a varying number of products independently are leveraged to create a bottom-up product platform. A top-down product platform approach based on a heterogeneous discrete choice model and a multiobjective genetic algorithm is presented that allow commonality decisions and product configuration to occur simultaneously. Using the platforming techniques presented in this paper, it is shown that the top-down platforming approach allows for more well-informed platformed design by providing knowledge of the tradeoff between commonality and market share.
Berichte der Organisationen zum Thema "TOR products"
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Merkulova, Yuliya. Роль системы показателей в технологии оптимизации и баланса множества данных спроса и предложения. Yuliya Merkulova, April 2021. http://dx.doi.org/10.12731/er0431.26042021.
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Article is devoted to significant problems of creation of system of the indicators for stimulation of balance of supply and demand of products. It is very important for increase of competitiveness of products. The new methodology of calculation of target function of a product and indicators of its efficiency is offered in article. The special place in article is devoted to methodology of definition of an indicator of aggregate useful effect, which includes useful effect of the producer and consumer and promotes balance of their interests. All offered indicators of efficiency of a product are interconnected with each other and only in united system possess the stimulating mechanism of balance of supply and demand. They promote increase of effectiveness of process of planning and allow to find reserves for increase of competitiveness of products.
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Rycroft, Taylor, Sabrina Larkin, Alexander Ganin, Treye Thomas, Joanna Matheson, Tessa Van Grack, Xinrong Chen, Kenton Plourde, Alan Kennedy und Igor Linkov. A framework and pilot tool for the risk-based prioritization and grouping of nano-enabled consumer products. Engineer Research and Development Center (U.S.), August 2021. http://dx.doi.org/10.21079/11681/41721.
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The use of engineered nanomaterials (ENMs) in consumer products has expanded rapidly, revealing both innovative improvements over conventional materials, and the potential for novel risks to human health and the environment. As the number of new nano-enabled products and the volume of toxicity data on ENMs continues to grow, regulatory agencies like the U.S. Consumer Product Safety Commission (CPSC) – a small, independent federal agency responsible for protecting consumers from unreasonable risks associated with product use – will require the ability to screen and group a diverse array of nano-enabled consumer products based on their potential risks to consumers. Such prioritization would allow efficient allocation of limited resources for subsequent testing and evaluation of high-risk products and materials. To enable this grouping and prioritization for further testing, we developed a framework that establishes a prioritization score by evaluating a nano-enabled product's potential hazard and exposure, as well as additional consideration of regulatory importance. We integrate the framework into a pilot version software tool and, using a hypothetical case study, we demonstrate that the tool can effectively rank nano-enabled consumer products and can be adjusted for use by agencies with different priorities. The proposed decision-analytical framework and pilot-version tool presented here could enable a regulatory agency like the CPSC to triage reported safety concerns more effectively and allocate limited resources more efficiently.
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McAfee, John D., und Richard C. Sorenson. Top Products. Fiscal Years 1991-1993. Fort Belvoir, VA: Defense Technical Information Center, November 1993. http://dx.doi.org/10.21236/ada274946.
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Seifert, Christin, und Veena Chattaraman. Too new or too complex? Why consumer's aesthetic sensitivity matters in product evaluation. Ames: Iowa State University, Digital Repository, November 2015. http://dx.doi.org/10.31274/itaa_proceedings-180814-181.
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van Haaster-de Winter, M. A., D. Taufik und R. Hovens. Natuurinclusieve producten : aankoopmotieven, betalingsbereidheid en keuzebewustzijn met betrekking tot natuurinclusieve producten. Wageningen: Wageningen Economic Research, 2018. http://dx.doi.org/10.18174/466226.
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Moores, Lee, Alan Kennedy, Lauren May, Shinita Jordan, Anthony Bednar, Stacy Jones, David Henderson, Luke Gurtowski und Kurt Gust. Identifying degradation products responsible for increased toxicity of UV-degraded insensitive munitions. Engineer Research and Development Center (U.S.), September 2021. http://dx.doi.org/10.21079/11681/42020.
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Degradation of insensitive munitions (IMs) by ultraviolet (UV) light has become a concern following observations that some UV-degradation products have increased toxicity relative to parent compounds in aquatic organisms. This investigation focused on the Army's IM formulation, IMX-101, composed of three IM constituents: 2,4-dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and nitroguanidine (NQ). The IM constituents and IMX-101 were irradiated in a UV photo-reactor and then administered to Daphnia pulex in acute (48 h) exposures comparing toxicities relative to the parent materials. UV-degradation of DNAN had little effect on mortality whereas mortality for UV-degraded NTO and NQ increased by factors of 40.3 and 1240, making UV-degraded NQ the principle driver of toxicity when IMX-101 is UV-degraded. Toxicity investigations for specific products formed during UV-degradation of NQ, confirmed greater toxicity than the parent NQ for degradation products. Summation of the individual toxic units for the complete set of individually measured UV-degradation products identified for NQ only accounted for 25% of the overall toxicity measured in the exposures to the UV-degraded NQ product mixture. Given the underestimation of toxicity using the sum toxic units for the individually measured UV-degradation products of NQ, we conclude that: (1) other unidentified NQ degradation products contributed principally to toxicity and/or (2) synergistic toxicological interactions occurred among the NQ degradation product mixture that exacerbated toxicity.
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Rosen, Karen B., Alan K. Meier und Stefan Zandelin. Energy use of set-top boxes and telephony products in the U.S. Office of Scientific and Technical Information (OSTI), Juni 2001. http://dx.doi.org/10.2172/785229.
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Bhattarai, Rabin, Yufan Zhang und Jacob Wood. Evaluation of Various Perimeter Barrier Products. Illinois Center for Transportation, Mai 2021. http://dx.doi.org/10.36501/0197-9191/21-009.
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Construction activities entail substantial disturbance of topsoil and vegetative cover. As a result, stormwater runoff and erosion rates are increased significantly. If the soil erosion and subsequently generated sediment are not contained within the site, they would have a negative off-site impact as well as a detrimental influence on the receiving water body. In this study, replicable large-scale tests were used to analyze the ability of products to prevent sediment from exiting the perimeter of a site via sheet flow. The goal of these tests was to compare products to examine how well they retain sediment and how much ponding occurs upstream, as well as other criteria of interest to the Illinois Department of Transportation. The products analyzed were silt fence, woven monofilament geotextile, Filtrexx Siltsoxx, ERTEC ProWattle, triangular silt dike, sediment log, coconut coir log, Siltworm, GeoRidge, straw wattles, and Terra-Tube. Joint tests and vegetated buffer strip tests were also conducted. The duration of each test was 30 minutes, and 116 pounds of clay-loam soil were mixed with water in a 300 gallon tank. The solution was continuously mixed throughout the test. The sediment-water slurry was uniformly discharged over an 8 ft by 20 ft impervious 3:1 slope. The bottom of the slope had a permeable zone (8 ft by 8 ft) constructed from the same soil used in the mixing. The product was installed near the center of this zone. Water samples were collected at 5 minute intervals upstream and downstream of the product. These samples were analyzed for total sediment concentration to determine the effectiveness of each product. The performance of each product was evaluated in terms of sediment removal, ponding, ease of installation, and sustainability.
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Alaska Boreal Forest Council, comps. Proceedings: hidden forest values—the first Alaska-wide nontimber forest products conference and tour. Portland, OR: U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station, 2003. http://dx.doi.org/10.2737/pnw-gtr-579.
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Singhvi, Punit, Javier García Mainieri, Hasan Ozer und Brajendra Sharma. Rheology-Chemical Based Procedure to Evaluate Additives/Modifiers Used in Asphalt Binders for Performance Enhancements: Phase 2. Illinois Center for Transportation, Juni 2021. http://dx.doi.org/10.36501/0197-9191/21-020.
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The increased use of softer binders in Illinois over the past decade is primarily attributed to the increased use of recycled materials in asphalt pavement construction. The shift in demand of using PG 58-28 over PG 64-22 has resulted in potential alternative methods to produce softer binders more economically using proprietary products. However, there are challenges in using these proprietary products for asphalt modification because of uncertainty in their long-term performance and significant variability in binder chemistry. The current SuperPave performance grading specification for asphalt binders is insufficient in differentiating binders produced from these modifiers. Therefore, the objective of this study is to evaluate the performance of various softener-type asphalt binder modifiers using a wide array of rheological and chemistry tests for their integration into the Illinois Department of Transportation’s material specifications. The small-strain rheological tests and their parameters allowed for consistent grouping of modified binders and can be used as surrogates to identify performing and nonperforming asphalt binders. A new parameter, Δ|G*|peak τ, was developed from the linear amplitude sweep test and showed potential to discriminate binders based on their large-strain behavior. Chemistry-based parameters were shown to track aging and formulation changes. The modifier sources were identified using fingerprint testing and were manifested in the modified binder chemical and compositional characteristics. The two sources of base binders blended with the modifiers governed the aging rate of the modified binders. Mixture performance testing using the Illinois Flexibility Index Test and the Hamburg Wheel-Track Test were consistent with the rheological and chemical findings, except for the glycol amine-based modified binder, which showed the worst cracking performance with the lowest flexibility index among the studied modifiers. This was contrary to its superior rheological performance, which may be attributed to lower thermal stability, resulting in high mass loss during mixing. According to the characterization of field-aged binders, laboratory aging of two pressurized aging vessel cycles or more may represent realistic field aging of 10 to 15 years at the pavement surface and is able to distinguish modified binders. Therefore, an extended aging method of two pressurized aging vessel cycles was recommended for modified binders. Two different testing suites were recommended for product approval protocol with preliminary thresholds for acceptable performance validated with field-aged data.