Thematische Bibliographien / Time-Of-Day administration of immunotherapy

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Bücher
  4. Buchteile
  5. Konferenzberichte
  6. Berichte der Organisationen

Auswahl der wissenschaftlichen Literatur zum Thema „Time-Of-Day administration of immunotherapy“

Autor: Grafiati
Veröffentlicht am 5. Oktober 2024

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Zeitschriftenartikel zum Thema "Time-Of-Day administration of immunotherapy"

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Arroyave Ramirez, Andres Mauricio, Daniel Motola, Mariana Guadalupe Morales Garcia, and Emilio Conde-Flores. "Impact of time-of-day administration of immunotherapy on overall survival among patients with metastatic renal cell carcinoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): e16537-e16537. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16537.

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e16537 Background: Circadian rhythm influences adaptive immune response. In recent years, some studies have suggested a relationship between the time of day of immune checkpoint inhibitor (ICI) infusions and disease outcomes among cancer patients. Evening infusions (after 4:30 pm) are associated with shorter overall survival. This study aims to determine whether the time of day of immunotherapy infusion affects the efficacy of treatment in patients with metastatic renal cell cancer (mRCC) in a Mexican population. Methods: This is an observational, retrospective, single-center study that includ
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Ortego, Ignacio, Javier Molina-Cerrillo, Alvaro Pinto, et al. "Time-of-day infusion of immunotherapy in metastatic urothelial cancer (mUC): Should it be considered to improve survival outcomes?" Journal of Clinical Oncology 40, no. 16_suppl (2022): e16541-e16541. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16541.

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e16541 Background: Immune-checkpoint inhibitors (ICIs) are key in the current management of mUC pts. Recent data in melanoma revealed a link in between the circadian rhythm of the immune-system and expected activity with ICIs (Quian et al, Lancet Oncol 2021). In preclinical models naïve CD4 and CD8 T cells in blood have shown to approach nadir levels around 4 P.M., and therefore, to lower adaptative immune responses after that time. We aimed to correlate the activity of single agent ICIs for the systemic treatment of mUC pts depending on the time of administration. Methods: This is a multicent
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Dougherty, David W., Houry Leblebjian, Megan Duperrault, et al. "Outcomes of immunotherapy administration for hospitalized cancer patients." Journal of Clinical Oncology 37, no. 27_suppl (2019): 98. http://dx.doi.org/10.1200/jco.2019.37.27_suppl.98.

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98 Background: With approvals across multiple cancer types and favorable toxicity profiles, oncologists may consider using immunotherapy (IMT) while their patients are hospitalized. Inpatient IMT may be cost-prohibitive to administer for most institutions due to high cost and inpatient payment structure, but little data are available to evaluate outcomes for IMT in hospitalized patients. We investigated the survival benefit of administering IMT to hospitalized patients with cancer at an NCI-designated cancer center. Methods: We conducted a retrospective chart review of all patients receiving i
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Leblebjian, Houry, Megan Duperrault, Brett Glotzbecker, et al. "Outcomes of immunotherapy administration for hospitalized cancer patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): e18225-e18225. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e18225.

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e18225 Background: With approvals across multiple cancer types and favorable toxicity profiles, oncologists may consider using immunotherapy (IMT) while their patients are hospitalized. Inpatient IMT may be cost-prohibitive to administer for most institutions due to high cost and inpatient payment structure, but little data are available to evaluate outcomes for IMT in hospitalized patients. We investigated the survival benefit of administering IMT to hospitalized patients with cancer at an NCI-designated cancer center. Methods: We conducted a retrospective chart review of all patients receivi
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Judd, Courtney A., Amy L. Parker, Eric A. Meier, and Michael S. Tankersley. "Successful administration of a 1-day imported fire ant rush immunotherapy protocol." Annals of Allergy, Asthma & Immunology 101, no. 3 (2008): 311–15. http://dx.doi.org/10.1016/s1081-1206(10)60497-8.

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Dvorak, Tomas, Thomas T. Maroney, Srujankumar Dhannapuneni, Ian Stephenson, and Amy Iarrobino Laughlin. "Assessment of outpatient chemotherapy and unplanned emergency department visits in a large community hospital system." Journal of Clinical Oncology 41, no. 16_suppl (2023): e18768-e18768. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18768.

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e18768 Background: Unplanned complications of outpatient chemotherapy can significantly affect patient oncologic outcomes, health, and increase cost of care. CMS rule OP-35 evaluates quality of care for Medicare patients by assessing the risk of emergency department (ED) visit within 30 days after outpatient chemotherapy administration. This study reviews this measure for all oncology patients treated in our community hospital setting. Methods: Patients treated between 02/2012 and 04/2021 were identified. Age at first chemotherapy administration, gender, cancer diagnosis, and chemotherapy regi
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Lissoni, Paolo, Sofia Meregalli, Vittorio Fossati, et al. "A Randomized Study of Immunotherapy with Low-Dose Subcutaneous Interleukin-2 plus Melatonin Vs Chemotherapy with Cisplatin and Etoposide as First-Line Therapy for Advanced Non-Small Cell Lung Cancer." Tumori Journal 80, no. 6 (1994): 464–67. http://dx.doi.org/10.1177/030089169408000611.

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Aims and Background The theraputic role of chemotherapy in advanced non-small cell lung cancer (NSCLC) is controversial because of its potentially detrimental action on host anticancer defenses. On the contrary, IL-2 would seem to prolong survival time by improving the immune status, even though it is generally less effective in determining tumor regression in NSCLC. Our previous studies have suggested the possibility of increasing tumor sensitivity to IL-2 by concomitant administration of immunomodulating neurohormones, such as the pineal hormone melatonin (MLT). On this basis, a study was ca
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Tsimafeyeu, I. V. "Nivolumab: 5 years from the day of international registration of immunotherapy of metastatic kidney cancer." Malignant tumours 10, no. 4 (2021): 21–29. http://dx.doi.org/10.18027/2224-5057-2020-10-4-21-29.

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Five years ago, on November 23, 2015, the US Food and Drug Administration (FDA) approved nivolumab for the treatment of metastatic renal cell carcinoma, thus ushering in a new era of immunotherapy for this tumor. The purpose of this review is to systematize the accumulated results of studies of nivolumab in monotherapy and in combinations.
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Senti, Gabriela, Bettina M. Prinz Vavricka, Iris Erdmann, et al. "Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial." Proceedings of the National Academy of Sciences 105, no. 46 (2008): 17908–12. http://dx.doi.org/10.1073/pnas.0803725105.

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The only causative treatment for IgE-mediated allergies is allergen-specific immunotherapy. However, fewer than 5% of allergy patients receive immunotherapy because of its long duration and risk of allergic side effects. We aimed at enhancing s.c. immunotherapy by direct administration of allergen into s.c. lymph nodes. The objective was to evaluate safety and efficacy compared with conventional s.c. immunotherapy. In a monocentric open-label trial, 165 patients with grass pollen-induced rhinoconjunctivitis were randomized to receive either 54 s.c. injections with pollen extract over 3 years [
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Lin, Lin, Ashraf S. Ibrahim, Beverlie Baquir, Andrew Palosaari, and Brad Spellberg. "Real-time tracking ATAK cells in vivo (52.1)." Journal of Immunology 186, no. 1_Supplement (2011): 52.1. http://dx.doi.org/10.4049/jimmunol.186.supp.52.1.

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Abstract Background: Activated Targeted Killer (ATAK) cells are a cellular immunotherapy which protects neutropenic mice from invasive candidiasis and aspergillosis. However,the lifespan and distribution of ATAK cells into organs has not been determined in vivo. Methods: ATAK cells were stably transfected with a luminescence reporter system. Neutropenic mice were imaged by IVIS after administration of coelentrazine substrate. RT-PCR was used to confirm the luminescence results. Results: On day 1 after ATAK cell administration, livers, kidneys, and spleens were infiltrated by the ATAK cells. By
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Dissertationen zum Thema "Time-Of-Day administration of immunotherapy"

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Karaboué, Abdoulaye. "Rôle du système circadien dans le contrôle de la survie des patients traités par immunothérapie pour cancer : Analyse des mécanismes impliqués." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ019.

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Mieux comprendre les mécanismes physiopathologiques et mieux cibler les traitements, selon les caractéristiques de la personne et de sa tumeur, font l'objet de recherches intensives , dans le cadre de la médecine cancérologique de précision et personnalisée. Celle-ci commence à intégrer les horloges circadiennes moléculaires, qui génèrent des oscillations périodiques d'environ 24 h du métabolisme, de la prolifération et de la mort cellulaire, ainsi que des réponses aux substances toxiques ou thérapeutiques. De nombreuses études expérimentales, cliniques et épidémiologiques ont montré le rôle i
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Reid, Kathryn J. "Day-time administration of melatonin : effects on core body temperature, sleep propensity and performance /." Title page and abstract only, 1993. http://web4.library.adelaide.edu.au/theses/09SB/09sbr356.pdf.

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Forrest, Rhonda. "Self-awareness of beginning leaders in child care centres." Thesis, Queensland University of Technology, 2002. https://eprints.qut.edu.au/36684/1/36684_Digitised%20Thesis.pdf.

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This thesis reports a phenomenological study of the lived experiences of six female beginning directors of Queensland child care centres. The perspectives of the participants were shared with the researcher over a five-month period through interviews, synergetic focus groups and drawings. Their stories revealed leaders inprocess who, being faced with new contexts, were forced to reconsider values and beliefs about themselves and the meaning of leadership. They described themselves as jugglers of multiple roles and relationships which often seemed overwhelming, particularly within time constrai
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Bücher zum Thema "Time-Of-Day administration of immunotherapy"

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David, Moxon, Tarling Roger, and Great Britain. Home Office. Research and Planning Unit., eds. Waiting time on the day in magistrates' courts: A review of case listing practices. Home Office, 1987.

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Knox, Catherine M. Medication administration and management. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199360574.003.0030.

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The courts and professional organizations recognize access to clinically appropriate and timely treatment with psychotropic medication as an essential element of an adequate correctional mental health system. While receiving treatment, incarcerated patients must be monitored and supervised clinically so that optimal patient outcomes are achieved. For many mentally ill inmates incarceration is an opportunity to receive treatment that was not accessible in the community; in one study only one third of those diagnosed with schizophrenia or bipolar disorder were receiving medication at the time of
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Knox, Catherine M. Medication administration and management. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199360574.003.0030_update_001.

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The courts and professional organizations recognize access to clinically appropriate and timely treatment with psychotropic medication as an essential element of an adequate correctional mental health system. While receiving treatment, incarcerated patients must be monitored and supervised clinically so that optimal patient outcomes are achieved. For many mentally ill inmates incarceration is an opportunity to receive treatment that was not accessible in the community; in one study only one third of those diagnosed with schizophrenia or bipolar disorder were receiving medication at the time of
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Moreno-Lax, Violeta. Chronology and Conceptualization of ‘Integrated Border Management’: The ‘Embodied Border’ Paradigm. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198701002.003.0002.

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Since the communautarisation of the Schengen acquis, the EU is meant to build a system of ‘integrated border management’ (IBM) to help ensuring the administration of migratory flows ‘at all their stages’. The idea is that effective entry control cannot be based solely on checks at the external borders of the Member States but ‘must cover every step taken by a third country national from the time he begins his journey to the time he reaches his destination’. EU entry/pre-entry controls thus comprise a series of extraterritorial measures carried out abroad. This chapter describes this evolution
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Ermatinger, James. The Roman Empire. ABC-CLIO, 2018. http://dx.doi.org/10.5040/9798216985280.

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Covering material from the time of Julius Caesar to the sack of Rome, this topically arranged reference set provides substantive entries on people, cities, government, institutions, military developments, material culture, and other topics related to the Roman Empire. The Roman Empire was one of the greatest and most influential forces of the ancient world, and many of its achievements endure in one form or another to this day. Because of its geographic breadth, cultural diversity, and overall complexity, it is also one of the most difficult organizations to understand. This book focuses on th
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Ermatinger, James W. Roman Empire. ABC-CLIO, 2018. http://dx.doi.org/10.5040/9798216985297.

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Covering material from the time of Julius Caesar to the sack of Rome, this topically arranged reference set provides substantive entries on people, cities, government, institutions, military developments, material culture, and other topics related to the Roman Empire. The Roman Empire was one of the greatest and most influential forces of the ancient world, and many of its achievements endure in one form or another to this day. Because of its geographic breadth, cultural diversity, and overall complexity, it is also one of the most difficult organizations to understand. This book focuses on th
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Bar, Joanna. Burundi: Państwo i społeczeństwo (od kolonializmu do współczesności). Ksiegarnia Akademicka Publishing, 2021. http://dx.doi.org/10.12797/9788381384131.

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BURUNDI: THE STATE AND SOCIETY (FROM THE COLONIAL PERIOD UNTIL THE PRESENT DAY) Burundi, a small country located in east-central Africa, is one of the most unstable countries on the continent. Similarly to the neighbouring Rwanda, over the last 50 years, the country has suffered tragic consequences of a civil war resulting from the conflict between politicians from the Tutsi and Hutu ethnic groups. The presented monograph covers a period of 130 years in a chronological manner, starting from the establishment of the foundations of the European colonial administration in the 1890s; however, the
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McDermott, Rory, and Craig Davidson. Oxygen: risks as well as benefits. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199657742.003.0015.

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Oxygen administration is the most commonly used therapy in emergency medicine. It is given to 18,000 patients in the United Kingdom every day, and 14% of patients in hospital receive it at some time during their stay. Whilst some of this activity is helpful, or indeed lifesaving, in some patients, oxygen can lead to harm, or even death. The domiciliary use of oxygen is also an area in which there is the potential for both waste and harm. When appropriately used, it prolongs life and provides valuable symptom relief; yet, in up to 43% of the cases, such therapy was either not used by patients a
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Liebovich, Louis W. Richard Nixon, Watergate, and the Press. Greenwood Publishing Group, Inc., 2003. http://dx.doi.org/10.5040/9798216008781.

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It's time to revisit Watergate. In this compelling reexamination, Liebovich draws extensively from newly available sources, including recently released Nixon Oval Office tapes, FBI reports, and personal reminiscences of cover-up leader John Dean. Liebovich sheds new light on the Nixon administration's extensive foul play, zeal to battle and manipulate the press, scandalous miring, and eventual political disgrace. After detailing the nation's news media coverage of the Watergate debacle and the ensuing breakup of American politics, Liebovich recounts the scandal's long-lasting, corrosive effect
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Johansen, Bruce, and Adebowale Akande, eds. Nationalism: Past as Prologue. Nova Science Publishers, Inc., 2021. http://dx.doi.org/10.52305/aief3847.

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Nationalism: Past as Prologue began as a single volume being compiled by Ad Akande, a scholar from South Africa, who proposed it to me as co-author about two years ago. The original idea was to examine how the damaging roots of nationalism have been corroding political systems around the world, and creating dangerous obstacles for necessary international cooperation. Since I (Bruce E. Johansen) has written profusely about climate change (global warming, a.k.a. infrared forcing), I suggested a concerted effort in that direction. This is a worldwide existential threat that affects every living t
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Buchteile zum Thema "Time-Of-Day administration of immunotherapy"

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Mitolo, Nicola, Paolo Nesi, Gianni Pantaleo, and Michela Paolucci. "Snap4City Platform to Speed Up Policies." In Smart and Sustainable Planning for Cities and Regions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57764-3_7.

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AbstractIn the development of smart cities, there is a great emphasis on setting up so-called Smart City Control Rooms, SCCR. This paper presents Snap4City as a big data smart city platform to support the city decision makers by means of SCCR dashboards and tools reporting in real time the status of several of a city’s aspects. The solution has been adopted in European cities such as Antwerp, Florence, Lonato del Garda, Pisa, Santiago, etc., and it is capable of covering extended geographical areas around the cities themselves: Belgium, Finland, Tuscany, Sardinia, etc. In this paper, a major use case is analyzed describing the workflow followed, the methodologies adopted and the SCCR as the starting point to reproduce the same results in other smart cities, industries, research centers, etc. A Living Lab working modality is promoted and organized to enhance the collaboration among municipalities and public administration, stakeholders, research centers and the citizens themselves. The Snap4City platform has been realized respecting the European Data Protection Regulation (GDPR), and it is capable of processing every day a multitude of periodic and real-time data coming from different providers and data sources. It is therefore able to semantically aggregate the data, in compliance with the Km4City multi-ontology and manage data: (i) having different access policies; and (ii) coming from traditional sources such as Open Data Portals, Web services, APIs and IoT/IoE networks. The aggregated data are the starting point for the services offered not only to the citizens but also to the public administrations and public-security service managers, enabling them to view a set of city dashboards ad hoc composed on their needs, for example, enabling them to modify and monitor public transportation strategies, offering the public services actually needed by citizens and tourists, monitor the air quality and traffic status to establish, if impose or not, traffic restrictions, etc. All the data and the new knowledge produced by the data analytics of the Snap4City platform can also be accessed, observing the permissions on each kind of data, thanks to the presence of an APIs complex system.
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Foster, Russell G., and Leon Kreitzman. "2. Time of day matters." In Circadian Rhythms: A Very Short Introduction. Oxford University Press, 2017. http://dx.doi.org/10.1093/actrade/9780198717683.003.0002.

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Numerous studies have shown that a broad range of activities—both physical and cognitive—vary across the 24-hour day. The blood pressure and heart rate of a human shows striking day–night variations. Simply, an organism is set up to function differently at different times of the day. ‘Time of day matters’ outlines the different human chronotypes—the different preferred waking and sleeping times of humans—and explains concepts such as ‘social jet lag’. There are optimal times of day for physical and cognitive activities, and chronotherapy has also shown that the administration of medication at different times of day can have an important impact on efficacy.
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Kumari, Divya, and Aleena Swetapadma. "An Intelligent Volatile Substance Time of Use Prediction System Using 1D Convolutional Neural Network Classifier." In Advances in Healthcare Information Systems and Administration. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-5422-0.ch008.

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Volatile substances are chemicals such as inhalants, glues, and solvents which are misused by people. In this work, the time of use of volatile substances is determined using seven personality features and five demographic information. 1D CNN is used for classification whether the user has consumed the volatile substances on last day, last week, last month, last year, or has never consumed. The accuracy obtained is 93.76% which is much higher than all previous studies on volatile substance abuse (VSA).
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"The Historic Conflicts of Our Time." In Contingent Citizens, edited by Patrick Q. Mason. Cornell University Press, 2020. http://dx.doi.org/10.7591/cornell/9781501716737.003.0014.

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This chapter talks about Ezra Taft Benson who commenced work as secretary of agriculture in the Dwight D. Eisenhower administration in 1953, while serving as one of the twelve apostles of the Church of Jesus Christ of Latter-day Saints. It describes Benson as a central figure in postwar American politics who represented the confluence and conflict between the various stripes of Mormon and American conservatism. It also discusses how Benson was the subject of national media interest and scrutiny in the 1950s and 1960. The chapter points out how Benson often took clear and controversially conservative positions on many of the historic conflicts of the twentieth century, such as anticommunism, the women's movement, international and domestic conflicts, and the culture wars. It traces American public representations of Mormonism by looking at Benson as a media filter.
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Jaszczolt, K. M. "Introduction: Thinking about time and living in time." In Representing Time: An Essay on Temporality as Modality. Oxford University PressOxford, 2009. http://dx.doi.org/10.1093/oso/9780199214433.003.0001.

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Abstract ‘I have no time!’, ‘There isn’t enough time in a day!’, are some of the most common expressions used in the academic world these days. Fast-growing numbers of hours that academics are required to devote to administration, teaching, and grant applications make more and more people resort to com- plaints about time. Perhaps it is worth asking oneself, what exactly do such expressions mean? If I don’t have time, what is it exactly that I don’t have? Let us imagine the following scenario. There is a ski lift going up a snowy mountain and a line of skiers waiting to catch it to be lifted up on their skis. The lift is moving at a certain steady speed and most of the skiers manage to latch on and go up, but some less experienced ones miss their slot or fall off the lift before they get to the top.
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Kilinç, Uğur. "Vitalizing Ancient Cultures Mythological Storytelling in Metal Music." In Advances in Public Policy and Administration. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7661-7.ch042.

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This chapter is focused on the relationship between ancient narratives “music” and “mythology.” Technological developments and changes in social structure caused the occurrence of different music genres over time. “Metal music” is one of these genres. In the present day, it is possible to observe that there is a tendency to mythology in sub-genres of metal music. This tendency is observed in lyrics, album artworks, videos, and gig performances of some bands. In this chapter, metal music is examined based on its root, content, and technical features, primarily. Afterwards, mythology, content of mythology, and cultural and social functions of mythology are discussed. In the praxis of this study, the cover of the album Twilight of the Thunder God (2008) of the Swedish metal band Amon Amarth is analyzed by semiological analysis.
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Best, Geoffrey. "First Lord of the Admiralty." In Churchill: A Study in Greatness. Oxford University PressNew York, NY, 2003. http://dx.doi.org/10.1093/oso/9780195161397.003.0005.

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Abstract Churchill enormously enjoyed his time at the Admiralty. (How much Clementine enjoyed it is another matter.) His pages about it in The World Crisis fizz with hyperactivity vividly recalled, giving the impression while you read them that he can have had no time for anything else—and also giving the impression that the senior admirals liked him more than most of them actually did. In fact the Royal Navy was by no means the only political problem he had to cope with at that time, and his work at the Admiralty was not as widely appreciated at the time as he thought it ought to be. These were great days. From dawn to midnight, day after day, one’s whole mind was absorbed by the fascination and novelty of the problems which came crowding forward. And all the time there was a sense of power to act, to form, to organize: all the ablest officers in the Navy standing ready, loyal and eager, with argument, guidance, information ... Saturdays, Sundays and any other spare day I spent always with the Fleets [of battleships] at Portsmouth or at Portland or Devonport, or with the Flotillas [ of destroyers and such] at Harwich. Officers of every rank came on board to lunch or dine and discussion proceeded without ceasing on every aspect of naval war and administration.
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Soczywko, Julita, and Dorota Rutkowska. "The Patient/Provider Relationship in Emergency Medicine." In Advances in Healthcare Information Systems and Administration. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3946-9.ch005.

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Emergency medicine is a rapidly developing medical specialty which focuses on the diagnostic process, initial stabilization, and the treatment of patients suffering from acute illnesses or injuries. Emergency care can be provided in prehospital settings by emergency medical services, as well as in emergency departments. The primary providers of emergency care are: emergency medicine physicians, emergency nurses, and paramedics. Emergency medical personnel are required to be prepared to take decisive action at any time of day or night. It is essential for them to possess basic knowledge relating to psychology and an ability to utilize interpersonal communication skills. A critical role of medical workers in emergency settings is to provide a patient with emotional support coupled with medical assistance. Interpersonal communication skills depend on the personal abilities of an individual, however, these skills can be also enhanced through training and work experience.
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Briggs, Adrian. "Foreign Judgments." In The Conflict of Laws. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198838500.003.0003.

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This chapter discusses the items of private international law of foreign judgments covered in part by a number of European regulations and other instruments prior to Exit Day. These are the Brussels I Regulation 44/2001 and the recast Brussels I Regulation 1215/2012; the 1988 Lugano Convention and the 2007 Lugano II Convention; the 1968 Brussels Convention as amended from time to time; and a number of minor Regulations such as the European Enforcement Order Regulation 805/2004. According to the Civil Jurisdiction and Judgments (Amendment) (EU Exit) Regulations 2019, SI 2019 No 479, on Exit Day these instruments are revoked or, in the case of the Conventions given effect by the Civil Jurisdiction and Judgments Act 1982, as amended, repealed. The gap will be filled by the rules of the common law, or by the provisions of a bilateral Convention made under the Foreign Judgements (Reciprocal Enforcement) Act 1933 (or in the case of Cyprus and Malta, presumably by registration under the Administration of Justice Act 1920).
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Pérez-Fragoso, Carmen. "Sharing Insights." In Cases on Technologies for Educational Leadership and Administration in Higher Education. IGI Global, 2012. http://dx.doi.org/10.4018/978-1-4666-1655-4.ch016.

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The case presents an analysis of the postings of a group of online teachers from a Mexican public university as they confront the challenges and rewards of their day-to-day teaching activities. They commented on their problems and accomplishments in a discussion forum during one semester. The problems included academic-administrative issues, difficulties of students in the appropriation of the platforms and the self-regulation of their learning, time management, negotiation and penalization of tasks delayed, and other pedagogical concerns to the lack of institutional support. The findings suggest that the problems that online teachers face share specific characteristics and, according to the teachers, are mostly due to the pedagogical relationship being technologically mediated. Through the analysis, the author hopes to illustrate the complex technological, organizational, and cultural issues that accompany online teaching and learning, and how the institution and the individual teachers dealt with them.
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Konferenzberichte zum Thema "Time-Of-Day administration of immunotherapy"

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Patel, Jimmy, Amber Draper, Yena Woo, et al. "848 Impact of immunotherapy time-of-day infusion on overall survival in patients with metastatic renal cell carcinoma." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0848.

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Randi, A. M., E. Sacchi, and M. Cattaneo. "ORALLY ADMINISTERED VITAMIN B PROLONGS THE BLEEDING TIME AND INHIBITS PLATELET AGGREGATION IN HUMAN VOLUNTEERS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643446.

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It is known that mM concentrations of vitamin B6 inhibit human platelet aggregation and fibrin formation in vitro. There are very few and controversial data on the ex vivo effects of vitamin B6 on hemostatic parameters. We evaluated the effects of oral administration of vitamin B6 on bleeding time (BT), fibrin formation, platelet aggregation (PA) and the release reaction (RR). Vitamin B6 300 mg/day p.o., was given to 18 healthy volunteers (8 M, 10 F, aged 23-35) for 8 days. BT was measured before the first dose (Baseline), 2 hr after the first (Day 1) and the last dose (Day 8). In 7 subjects B
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FAIVRE, R., E. NEUHART, Y. KIEFFER, F. TOULEMONDE, J. P. BASSAND, and J. P. MAURAT. "SUBCUTANEOUS ADMINISTRATION OF A LOW MOLECULAR WEIGHT HEPARIN (CY 222) COMPARED WITH SUBCUTANEOUS ADMINISTRATION OF STANDARD HEPARIN IN PATIENTS WITH ACUTE DEEP VEIN THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643229.

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68 patients (pts) with acute deep vein thrombosis (DVT) were randomized to either CY 222 (Choay Institut, Cl, France) (n=33) in a dose of 750 u anti-Xa Cl/kg/day or standard heparin (SH) (n=35), 500 ui/kg/day, both given by 2 daily subcutaneous (sc) injections for 10 days. In SH group, dose was monitored by daily activated partial thromboplastin time to maintain a prolongation between 2 to 3 times the control value ; in CY 222 group dose remained unchanged during the 10-day treatment. Venography was repeated at day 10. Initial DVT localization and derived Marder’s score was similar in both gro
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Elawady, Ahmed, Muamer Abuzwidah, Samer Barakat, and Jae Young Lee. "Predicting Traffic Accidents Severity Using Multiple Analytical Techniques." In International Symposium on Engineering and Business Administration. Trans Tech Publications Ltd, 2023. http://dx.doi.org/10.4028/p-i7bq7v.

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Road accidents are a major world economic and social problem, as shown by the report of loss of lives and properties in many countries worldwide. Reporting indicated the number of fatalities from road accidents per year of about 1.35 million and 50 million injuries was recorded or an average of 3000 deaths/day and 30,000 injuries/ day. Furthermore, its consequences have an impact on economic and social conditions in terms of health care costs of injuries and disabilities. The objectives of this paper are to implement four modeling techniques, Logistic Regression, Naïve Bayes, Support Vector Ma
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Naeem, Marwan, Emran Alotaibi, Yousef Elbaz, Muamer Abuzwidah, and Samer Barakat. "Assessment of Drowsy Driving Associated Characteristics Using Deep Learning." In International Symposium on Engineering and Business Administration. Trans Tech Publications Ltd, 2023. http://dx.doi.org/10.4028/p-vrat6i.

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The presence of road traffic accidents is subjected to various contributing factors including drowsy driving. The occurrence of drowsy driving has been a major cause of road accidents globally. Therefore, this study aims to analyze demographic, socio-economic, daily habits and drowsy-related characteristics associated with fatigued or drowsy driving in the United Arab Emirates (UAE). The data were gathered upon a questionnaire-based survey among a sample size of 525 drivers in the UAE. Inputs were given weights upon consulting experts in the field of transportation. Data were analyzed using ar
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R., Senthil J., Santa A., Pavan KB, et al. "An Analysis of Acute Adverse Drug Reactions Occurring in Day Care Chemotherapy Setting in a Tertiary Care Cancer Centre." In Annual Conference of Indian Society of Medical and Paediatric Oncology (ISMPO). Thieme Medical and Scientific Publishers Pvt. Ltd., 2021. http://dx.doi.org/10.1055/s-0041-1735376.

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Abstract Introduction Acute adverse drug reactions (ADRs) in day care chemotherapy are not uncommon and easily manageable many a time. However, sometimes they may lead to untoward events. It is of paramount importance to document and analyze such events in contemporary medical oncology practice for the best utilization and planning of available personnel and resources. Objectives This study was aimed to analyze the acute ADRs occurring in day care cancer chemotherapy setting. Materials and Methods All acute ADRs reported in day care cancer chemotherapy setting, during the administration of che
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Hetelekides, Eleftherios, Verlin Joseph, Adrian Bravo, Mark Prince, Bradley Conner, and Matthew Pearson. "Early Birds and Night Owls: Distinguishing Profiles of Cannabis Use Habits by Use Times with Latent Class Analysis." In 2021 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2022. http://dx.doi.org/10.26828/cannabis.2022.01.000.19.

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Negative consequences associated with excessive use of cannabis are well documented. Previous findings indicate timing of use is an important factor when assessing severity of dependence for use of substances including alcohol and cigarettes. However, little attention in the academic literature has been paid to timing of cannabis use and its associations with negative consequences. The present study employed a latent class analysis on data collected from college students who use cannabis, located across four U.S. universities in four different states (N = 1,122). The goal was to examine whethe
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Gachet, C., A. Stierlé, C. Bouloux, J.-P. Maffrand, and J.-P. Cazenave. "THE THIENOPYRIDINE PCR 4099 INHIBITS THE ADP AGGREGATION PATHWAY OF HUMAN PLATELETS BY INTERFERING WITH THE BINDING OF FIBRINOGEN TO THE GLYCOPROTEIN IIb-IIIa COMPLEX." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643581.

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The thienopyridine, PCR 4099, is a synthetic structural analog of ticlopidine. After oral administration in man, it prolongs the bleeding time (BT) and inhibits ADP-induced aggregation. The aim of the study was to evaluate the effects of oral administration of 200 mg per day PCR 4099 to 10 human volunteers for 7 days on primary hemostasis and to study the mechanism of inhibition of the drug on the ADP-fibrinogen-GPIIb-IIIa pathway of aggregation. BT (measured by a Simplate device) was 4-8 min before treatment and 30 min after 7 days of treatment. Platelets were washed and resuspended in Tyrode
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Kariyone, S., M. Hirakuri, T. Yui, and T. Uchida. "EVALUATION ON EFFECTIVENESS OF LOW DOSE ASPIRIN THERAPY FOR PROTECTION OF THROMBUS FORMATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644817.

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In order to protect thrombus formation, administration of low dose aspirin has become common. However, its significance for this purpose is still not clear. Effect of small dose of aspirin (ASA) onplatelet aggregation and ability of malondialdehyde(MDA) formation in platelet by the addition of arachidonic acid in vitro were investigated. In clinical study, platelet aggregation, MDA formation of platelet, serum P-thromboglobulin(p-TG), platelet factor 4(PF4) and thromboxane B2(TX-B2) levelswere measured before and after low doseaspirin therapy.Platelet aggregations by ADP, collagen, epinephrin
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DAMAS, J., V. GREGG, and G. REMACLE-VOLON. "INHIBITION OF THE THROMBOPENIC EFFECT OF ELLAGIC ACID BY PCR 4099, AN ANTIAGGRGATING AGENT, IN RATS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643449.

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In the rat, intravenous injection of large doses (30 mg/Kg) of ellagic acid (EA) induced a decrease in the plasma level of fibrinogen and in the blood platelet content and an increase of the activated partial thromboplastin time. EA induced the accumulation of Crs1-labelled platelets into the lung and the liver accompanied by a 64% fall in Cr51 blood radioactivity.The long-lasting thrombocytopenia induced by EA was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), and clocoumarol (4 mg/Kg). It was not inhibited by aspirin (90 mg/Kg), indomethacin (8 mg/Kg) and ketoprofen (4-10 mg/Kg). The t
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Berichte der Organisationen zum Thema "Time-Of-Day administration of immunotherapy"

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Kulhandjian, Hovannes. Detecting Driver Drowsiness with Multi-Sensor Data Fusion Combined with Machine Learning. Mineta Transportation Institute, 2021. http://dx.doi.org/10.31979/mti.2021.2015.

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In this research work, we develop a drowsy driver detection system through the application of visual and radar sensors combined with machine learning. The system concept was derived from the desire to achieve a high level of driver safety through the prevention of potentially fatal accidents involving drowsy drivers. According to the National Highway Traffic Safety Administration, drowsy driving resulted in 50,000 injuries across 91,000 police-reported accidents, and a death toll of nearly 800 in 2017. The objective of this research work is to provide a working prototype of Advanced Driver Ass
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Boisclair, Yves R., and Arieh Gertler. Development and Use of Leptin Receptor Antagonists to Increase Appetite and Adaptive Metabolism in Ruminants. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697120.bard.

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Objectives The original project had 2 major objectives: (1) To determine the effects of centrally administered leptin antagonist on appetite and adaptive metabolism in the sheep; (2) To develop and prepare second-generation leptin antagonists combining high binding affinity and prolonged in vivo half-life. Background Periods of suboptimal nutrition or exaggerated metabolic activity demands lead to a state of chronic energy insufficiency. Ruminants remain productive for a surprisingly long period of time under these circumstances by evoking adaptations sparing available energy and nutrients. Th
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Meidan, Rina, and Joy Pate. Roles of Endothelin 1 and Tumor Necrosis Factor-A in Determining Responsiveness of the Bovine Corpus Luteum to Prostaglandin F2a. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695854.bard.

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The corpus luteum (CL) is a transient endocrine gland that has a vital role in the regulation of the estrous cycle, fertility and the maintenance of pregnancy. In the absence of appropriate support, such as occurs during maternal recognition of pregnancy, the CL will regress. Prostaglandin F2a (PGF) was first suggested as the physiological luteolysin in ruminants several decades ago. Yet, the cellular mechanisms by which PGF causes luteal regression remain poorly defined. In recent years it became evident that the process of luteal regression requires a close cooperation between steroidogenic,
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