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1
Sirbu, Rodica, Ticuta Negreanu-Pirjol und Bogdan Stefan Negreanu-Pirjol. „Important Properties of Grapes and Wine from the Dobrogea Area for Therapeutic Use“. European Journal of Medicine and Natural Sciences 4, Nr. 2 (15.10.2021): 59. http://dx.doi.org/10.26417/746ygx85s.
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Starting from Herodotus who states that: No cure can cure like wine and can not inspire like it. From antiquity until now grapes and wine represent a viable alternative in multiple therapies if we know how and when to consume these products. This paper is a study that comes to present concretely the beneficial impact of the products that the vine offers us, the plant cultivated in the location of our Dobrogean area. Grapes contain reducing sugars, malic acid, succinic acid, flavonic derivatives, lecithin, choline, leucine, wax and minerals. Wine also has special properties in cellular and mental balance, being a good anti-stress remedy. Medicinal wines are elixirs with beneficial effects on health only if they are prepared correctly. In this paper important properies of wine and grapes are analised and application of wines and their specific effects in different therapies was systematized. The paper aims to open interest in this topic for scientifically controlled consumption and for the use of these natural products in beneficial alternative therapies.
2
Gallagher, Lisa M., und Francois Bethoux. „Therapeutic use of the Arts for Patients with Multiple Sclerosis“. US Endocrinology 13, Nr. 02 (2017): 82. http://dx.doi.org/10.17925/use.2017.13.02.82.
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People with multiple sclerosis (MS) face a wide variety of physical, emotional, and social challenges. A multidisciplinary comprehensive care approach is recommended for the management of MS and its consequences, and non-traditional treatments are increasingly considered by patients and health care providers, particularly for the promotion of wellness in the context of this chronic disease. Previous research has demonstrated the benefits of the therapeutic arts (art therapy, dance and movement therapy, and music therapy) in addressing some of the physiological, psychological, cognitive, social, and spiritual needs of patients facing a variety of chronic illnesses. Our review of the literature suggests that therapeutic art can be beneficial to individuals with MS, particularly in promoting self-efficacy, emotional well-being, and motor control. However, the body of evidence is limited, and further research is needed regarding the outcomes and mechanism of action of therapeutic arts in MS to better understand their role in the management of the consequences of the disease.
3
Zhang, Songxia, Ying Xu, Mengling Ye, Wenli Ye, Jian Xiao, Honghao Zhou, Wei Zhang, Yan Shu, Yun Huang und Yao Chen. „Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky“. Nutrients 14, Nr. 22 (10.11.2022): 4752. http://dx.doi.org/10.3390/nu14224752.
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People in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective on the use of herbal wine. To simulate the behaviour of herbal wine users, RSV (15 mg/kg) soaked in ethanol (RSV-alcohol) was administrated via gavage to the mice, here with alcohol consumption-induced ALD. RSV soaked in water (RSV-water) was the treatment control. The efficacy and safety of RSV on ALD were evaluated. Compared with the RSV-water group, a higher rate of mortality was found in the RSV-alcohol group (50.0% vs. 20.0%), which also exhibited more severe liver injury. RSV significantly increased the exposure of alcohol by 126.0%, which was accompanied by a significant inhibition of the ethanol metabolic pathway. In contrast, alcohol consumption significantly reduced exposure to RSV by 95.0%. Alcohol consumption had little effect on the expression of drug-metabolizing enzymes in RSV; however, alcohol seemed to reduce the absorption of RSV. RSV in liquor exacerbates alcoholic liver injury and has a reduced therapeutic effect, suggesting that the habit of herbal wine use without supervision is risky.
4
Piccolo, D., D. Di Marcantonio, G. Crisman, G. Cannarozzo, M. Sannino, A. Chiricozzi und S. Chimenti. „Unconventional Use of Intense Pulsed Light“. BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/618206.
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According to the literature, intense pulsed light (IPL) represents a versatile tool in the treatment of some dermatological conditions (i.e., pigmentation disorders, hair removal, and acne), due to its wide range of wavelengths. The authors herein report on 58 unconventional but effective uses of IPL in several cutaneous diseases, such as rosacea (10 cases), port-wine stain (PWS) (10 cases), disseminated porokeratosis (10 cases), pilonidal cyst (3 cases), seborrheic keratosis (10 cases), hypertrophic scar (5 cases) and keloid scar (5 cases), Becker’s nevus (2 cases), hidradenitis suppurativa (2 cases), and sarcoidosis (1 case). Our results should suggest that IPL could represent a valid therapeutic support and option by providing excellent outcomes and low side effects, even though it should be underlined that the use and the effectiveness of IPL are strongly related to the operator’s experience (acquired by attempting at least one specific course on the use of IPL and one-year experience in a specialized centre). Moreover, the daily use of these devices will surely increase clinical experience and provide new information, thus enhancing long-term results and improving IPL effectiveness.
5
Miao, Ming San, Lin Guo, Shan Cao und Xiao Fang Guo. „The Research of Topical Analgesic Effect on Arisaema Wine Paste, Vinegar Paste“. Applied Mechanics and Materials 664 (Oktober 2014): 429–32. http://dx.doi.org/10.4028/www.scientific.net/amm.664.429.
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To study the analgesic effect of Arisaema wine paste, vinegar paste for external use. By two pain tests induced by formaldehyde and by hot plate ,observing the effect of high and low-dose of different varieties Arisaema with wine paste and vinegar paste on the the behavior of model mice.In the pain tests induced by formaldehyde,after administration of 5min and 10min,high and low-dose of different varieties Arisaema with wine paste and vinegar paste can significantly reduced the number of times of mice licking foot (P<0.01).In the pain tests induced by hot plate,after the administration of 30min ~ 90min, ,high and low-dose of different varieties Arisaema with wine paste and vinegar paste can significantly significantly increased the pain threshold of mice (P<0.01). Arisaema topical has good therapeutic effect on mice induced pain model, and topical analgesic effect of Arisaema is better.
6
Gallagher, Lisa M., und Francois Bethoux. „Therapeutic use of the Arts for Patients with Multiple Sclerosis“. US Neurology 13, Nr. 02 (2017): 82. http://dx.doi.org/10.17925/usn.2017.13.02.82.
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People with multiple sclerosis (MS) face a wide variety of physical, emotional, and social challenges. A multidisciplinary comprehensive care approach is recommended for the management of MS and its consequences, and non-traditional treatments are increasingly considered by patients and health care providers, particularly for the promotion of wellness in the context of this chronic disease. Previous research has demonstrated the benefits of the therapeutic arts (art therapy, dance and movement therapy, and music therapy) in addressing some of the physiological, psychological, cognitive, social, and spiritual needs of patients facing a variety of chronic illnesses. Our review of the literature suggests that therapeutic art can be beneficial to individuals with MS, particularly in promoting self-efficacy, emotional well-being, and motor control. However, the body of evidence is limited, and further research is needed regarding the outcomes and mechanism of action of therapeutic arts in MS to better understand their role in the management of the consequences of the disease.
7
Bohara, Raghvendra A., Nazish Tabassum, Mohan P. Singh, Giuseppe Gigli, Andrea Ragusa und Stefano Leporatti. „Recent Overview of Resveratrol’s Beneficial Effects and Its Nano-Delivery Systems“. Molecules 27, Nr. 16 (12.08.2022): 5154. http://dx.doi.org/10.3390/molecules27165154.
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Natural polyphenols have a wide variety of biological activities and are taken into account as healthcare materials. Resveratrol is one such natural polyphenol, belonging to a group known as stilbenoids (STBs). Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is mainly found in grapes, wine, nuts, and berries. A wide range of biological activities has been demonstrated by resveratrol, including antimicrobial, antioxidant, antiviral, antifungal, and antiaging effects, and many more are still under research. However, as with many other plant-based polyphenol products, resveratrol suffers from low bioavailability once administered in vivo due to its susceptibility to rapid enzyme degradation by the body’s innate immune system before it can exercise its therapeutic influence. Therefore, it is of the utmost importance to ensure the best use of resveratrol by creating a proper resveratrol delivery system. Nanomedicine and nanodelivery systems utilize nanoscale materials as diagnostic tools or to deliver therapeutic agents in a controlled manner to specifically targeted locations. After a brief introduction about polyphenols, this review overviews the physicochemical characteristics of resveratrol, its beneficial effects, and recent advances on novel nanotechnological approaches for its delivery according to the type of nanocarrier utilized. Furthermore, the article summarizes the different potential applications of resveratrol as, for example, a therapeutic and disease-preventing anticancer and antiviral agent.
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Gubergrits, N. B., N. V. Byelyayeva, A. Ye Klochkov, P. G. Fomenko und G. M. Lukashevich. „Engilen: from different therapeutic possibilities to effective clinical use“. Herald of Pancreatic Club 43, Nr. 2 (03.05.2019): 70–81. http://dx.doi.org/10.33149/vkp.2019.02.10.
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Composition of the Engilen preparation, medicinal properties of plants that make up the preparation, indications for its prescription are analyzed in detail in the article. Particular attention is paid to the advantages of Engilen, such as: optimal doses and ratio of active ingredients, wide range of indications, effectiveness upon combined diseases of the digestive system and with the concomitant pathology of other organs and systems. The results of our own study are presented, showing the effectiveness of Engilen upon chronic acalculous cholecystitis and non-alcoholic steatohepatitis in patients with excessive body mass or obesity. In addition, an effective correction of various types of the gall-bladder dysfunction has been obtained.
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Zhang, Ming-Qiang. „Chemistry Underlying the Cardiotoxicity of Antihistaminest“. Current Medicinal Chemistry 4, Nr. 3 (Juni 1997): 171–84. http://dx.doi.org/10.2174/0929867304666220313110659.
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Antihistamines are very useful therapeutic agents for the treatment of allergic diseases, and are one of the most frequently prescribed medicines world-wide. Despite the excellent safety record of antihistamines, the recent reports on cardiac toxicity associated with the use of antihistamines have caused wide-spread concerns among both the scientific community and the general public. This review delineates the molecular factors underlying this potentially devastating side effect of the otherwise . very safe therapeutics, including their pharmacodynamic activities on car d1ac potass1um channels and pharmacokinetic interactions with other therapeutic agents. The discussion is mainly based on structure-activity relationship of these agents and their cardiotoxicity, so to predict and prevent potential therapeutic hazards. Implications for future drug development as well as rational use of other therapeutic agents are also discussed.
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Tolstun, Denis, Khachik Muradian und Vladislav Bezrukov. „Therapeutic hypercapnia. Review“. Issue 3 2022, Nr. 3 2022 (28.08.2022): 101–13. http://dx.doi.org/10.47855/al9020-2022-3-5.
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In recent years, interest in hypercapnia and its practical applications has grown significantly. An analysis of literature data shows a wide range of systemic and local applications. Due to its powerful effect on blood circulation, vascular elasticity, activation of angiogenesis, and inhibition of pro-inflammatory factors, hypercapnia is already used in dermatology, phlebology, and therapy. Wide opportunities open up for practical use in neurology, given the powerful neuroprotective effect of carbon dioxide, which not only increases tolerance to ischemia, preventing the development of diseases but can also become a tool for the treatment of stroke and heart attack. The antitumor effect and the ability to reduce the level of metabolic processes also make hypercapnia an attractive geroprotector that will help in solving the issue of life extension. Keywords: hypercapnia; hypoxia; cancer; diabetes; neuroprotection; longevity; carboxytherapy; ischemia; stroke
11
Balanov, Petr E., Irina V. Smotraeva, Malika S. Abdullaeva, Daria A. Volkova und Olga B. Ivanchenko. „Study on resveratrol content in grapes and wine products“. E3S Web of Conferences 247 (2021): 01063. http://dx.doi.org/10.1051/e3sconf/202124701063.
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The current state of the agro-industrial complex and the food industry allows to satisfy the needs of various consumers groups. Among those needs, functional foods enriched with beneficial nutrients are becoming more and more popular. Polyphenols are sometimes used as such additives. The bioflavonoid resveratrol, among the group of polyphenols, has very promising antioxidant, therapeutic, antimicrobial properties. In this regard, studying the potential of its use in the food is highly relevant. Resveratrol is naturally present in the dark grapes. It is localized in the skin of the fruit and passes into the food substance during technological processing. This transition has its own patterns which are outlined in this article. Three varieties of grapes were chosen as the objects of the study: Cabernet Sauvignon, Merlot, Krasnostop. Clarified musts from these grape varieties, concentrated musts and wines were researched. High performance liquid chromatography (HPLC) was utilized as the research method. This method allows to separate liquids of complex composition into components with subsequent identification of the mixture composition. To calibrate the chromatograph, the standard “25 mg European Pharmacopoeia”, produced in France, was used as a standard for the pure substance of resveratrol. As the result of the study, it was found that resveratrol is present in the studied samples in various amounts from 4,4 to 7,0 mg / dm³ in the grape juice, from 6,9 to 12,6 mg/dm³ in the wine materials, from 12,4 to 21,3 mg / dm³ in the concentrated juice. These data help establishing the influence of the processing technology of wine and juice concentrates on the resveratrol content. The article also discusses the potential of using concentrated grape juice, rich in resveratrol, to obtain various food products.
12
Bukhari, Syed Nasir Abbas. „Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight“. Antioxidants 11, Nr. 3 (15.03.2022): 554. http://dx.doi.org/10.3390/antiox11030554.
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Dietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are either derivatives or isomers of phenol acid, isoflavonoids and possess hidden health promoting characteristics, such as antioxidative, anti-aging, anti-cancerous and many more. The use of such polyphenols in combating the neuropathological war raging in this generation is currently a hotly debated topic. Lately, Alzheimer’s disease (AD) is emerging as the most common neuropathological disease, destroying the livelihoods of millions in one way or another. Any therapeutic intervention to curtail its advancement in the generation to come has been in vain to date. Using dietary polyphenols to construct the barricade around it is going to be an effective strategy, taking into account their hidden potential to counter multifactorial events taking place under such pathology. Besides their strong antioxidant properties, naturally occurring polyphenols are reported to have neuroprotective effects by modulating the Aβ biogenesis pathway in Alzheimer’s disease. Thus, in this review, I am focusing on unlocking the hidden secrets of dietary polyphenols and their mechanistic advantages to fight the war with AD and related pathology.
13
Wang, Xingtao, Chunlai Tian, Xingguang Duan, Ying Gu und Naiyan Huang. „A Medical Manipulator System with Lasers in Photodynamic Therapy of Port Wine Stains“. BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/384646.
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Port wine stains (PWS) are a congenital malformation and dilation of the superficial dermal capillary. Photodynamic therapy (PDT) with lasers is an effective treatment of PWS with good results. However, because the laser density is uneven and nonuniform, the treatment is carried out manually by a doctor thus providing little accuracy. Additionally, since the treatment of a single lesion can take between 30 and 60 minutes, the doctor can become fatigued after only a few applications. To assist the medical staff with this treatment method, a medical manipulator system (MMS) was built to operate the lasers. The manipulator holds the laser fiber and, using a combination of active and passive joints, the fiber can be operated automatically. In addition to the control input from the doctor over a human-computer interface, information from a binocular vision system is used to guide and supervise the operation. Clinical results are compared in nonparametric values between treatments with and without the use of the MMS. The MMS, which can significantly reduce the workload of doctors and improve the uniformity of laser irradiation, was safely and helpfully applied in PDT treatment of PWS with good therapeutic results.
14
Ito, Matthew K. „Statin Drug Interactions in Patients with Comorbidities and on Multiple Medications“. US Endocrinology 08, Nr. 02 (2012): 104. http://dx.doi.org/10.17925/use.2012.08.02.104.
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Extensive clinical evidence has demonstrated the efficacy of statin treatment in the prevention of cardiovascular disease (CVD). However, nearly half of patients taking statins discontinue their use, largely as a result of side effects. Many patients receiving statins are elderly, and/or have comorbid conditions, increasing the potential for drug-drug interactions (DDIs). Statin DDIs are largely the result of altered drug metabolism via cytochrome P450s (CYPs), glucuronidation or altered drug transport via organic anion-transporting polypeptides (OATPs) and P-glycoprotein (P-gp). There is a need for discussion and education about DDIs within the clinical consultation. Statins that are not significantly metabolized via the CYP system have a reduced risk of DDIs. To date, pitavastatin has shown a low rate of DDIs compared to other available statins metabolized by CYP3A4 isozymes. Its potential for CYP-mediated DDIs has been studied in combination with a wide range of drug classes known to be CYP inhibitors and has been clinically evaluated in patients populations where multiple medications are used, including the elderly, those high risk of CVD, and those taking protease inhibitors. It may also have beneficial effects on parameters of glucose metabolism, and has shown improved outcomes in patients with chronic kidney disease. Knowledge of statin pharmacokinetics, their dose limitations and contraindications, and their mechanisms of DDI allows improved therapeutic choices, avoiding adverse interactions without compromising patient care.
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Baysan, Aylin, und Edward Lynch. „The Use of Ozone in Dentistry and Medicine“. Primary Dental Care os12, Nr. 2 (April 2005): 47–52. http://dx.doi.org/10.1308/1355761053695158.
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There is growing interest in the use of ozone in oral healthcare and the National Institute for Clinical Excellence (NICE) is at present reviewing the evidence for its effectiveness in the management of occlusal and plain surface caries. These are only two of the clinical problems for which ozone can, and has, been used; it has also been employed for a wide variety of other purposes in both dentistry and medicine. This pale blue-coloured gas plays an important role as a natural constituent in the higher layer of the Earth's atmosphere. There is growing evidence that it can be employed as a useful therapeutic agent. This paper reviews its therapeutic uses to date and suggests its possible future clinical applications. Consumer demands for this strong oxidant may increase as the general public becomes increasingly aware of its therapeutic capacity and the non-invasive manner in which it can be administered.
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Roshani P Gandhi, Gautam D Mehetre, Shital J Gandhi und Shivani P Wadichar. „A systematic review of therapeutic proteins as a promising approach to treat various diseases“. GSC Biological and Pharmaceutical Sciences 22, Nr. 1 (30.01.2023): 157–69. http://dx.doi.org/10.30574/gscbps.2023.22.1.0016.
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Proteins if said as ‘magic molecules’ will not prove false because of a varied play it can deal with in view of health sector. In the past couple of decades, therapeutic proteins have gained significance as therapy for a wide range of diseases like cancer, cardiovascular, diabetes and some other diseases. Moreover, recently USFDA protein therapeutic products are also playing an important role in this concern. Whereas therapeutic application of whey protein is rapidly on its way to be proved helpful. The thing of concern to use of these therapeutic proteins for the treatment of various diseases is a proper and rational formulation of protein-based therapeutics. Advancements in the field of biotechnology have increased and facilitated the production of therapeutically significant proteins to combat various potentially fatal diseases. However, there are still a few factors that hinder the efficient use of these valuable therapeutics. For instance, the oral route of administration faces proteolysis and/or hydrolysis in the GIT, whereas some drugs go through the hepatic first pass effect or show poor distribution. Therefore, a better insight into the routes of administration and the drug absorption mechanisms (paracellular, transcellular, and carrier mediated) is essential. This review has explained all the possible factors that are linked with the basis of therapeutic proteins, including their introduction, classification, their importance in the healthcare system, and possible challenges that are currently being faced by scientists during the development of protein-based therapeutics.
17
Shilin, D. Ye, I. I. Dedov und Ye A. Grigoryeva. „Spironolactone therapeutic effect in the hyperandrogenism syndrome“. Problems of Endocrinology 39, Nr. 2 (15.04.1993): 55–60. http://dx.doi.org/10.14341/probl11979.
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Hyperandrogenism syndrome, the main manifestations of which are pathological hirsutism, acne, oily seborrhea, androgenic alopecia, accompanies a wide range of diseases of the female reproductive system, manifested by various disorders of menstrual function and infertility. Isolated hirsutism is also a serious psychological and cosmetic problem, especially since almost one in ten women of reproductive age have excessive hair growth. To get rid of "excess" hair, women use various methods. However, in severe manifestations of hyperandrogenism or in the case of severe and moderate hirsutism, it is advisable to use systemic antiandrogenic therapy.
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Rzeźnicka, Zofia, und Maciej Kokoszko. „Wine and Myrrh as Medicaments or a Commentary on Some Aspects of Ancient and Byzantine Mediterranean Society“. Studia Ceranea 9 (30.12.2019): 615–55. http://dx.doi.org/10.18778/2084-140x.09.31.
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The present study has resulted from a close reading of prescriptions for therapeutic wines inserted in book V of De materia medica by Pedanius Dioscorides, the eminent expert in materia medica of the 1st century A.D. The authors emphasise the role of wine varieties and selected flavourings (and especially of myrrh) in order to determine the social status of those to whom the formulas were addressed. This perspective gives the researchers ample opportunity for elaborating not only on the significance of wine in medical procedures but also for underscoring the importance of a number of aromatics in pharmacopoeia of antiquity and Byzantium. The analysis of seven selected formulas turns out to provide a fairly in-depth insight into Mediterranean society over a prolonged period of time, and leads the authors to draw the following conclusions. First, they suggest that medical doctors were social-inequality-conscious and that Dioscorides and his followers felt the obligation to treat both the poor and the rich. Second, they prove physicians’ expertise in materia medica, exemplifying how they were capable of adjusting market value of components used in their prescriptions to financial capacities of the patients. Third, the researchers circumstantiate the place of medical knowledge in ancient, and later on in Byzantine society. Last but not least, they demonstrate that medical treatises are an important source of knowledge, and therefore should be more often made use of by historians dealing with economic and social history of antiquity and Byzantium.
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Connolly, A. „Replacing Sub - Therapeutic Antibiotics in Feed with Consumer Acceptable Performance Enhancers“. Open Access Journal of Veterinary Science & Research 2, Nr. 1 (2017): 1–13. http://dx.doi.org/10.23880/oajvsr-16000122.
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Since introduction in the late 1940s, the role of antibiotics in animal production has changed. Originally a means of combating illnesses and maintaining the health of flocks and herds, it was soon recognized that antibiotics could drastically increase productivity and financial return through enhanced and expedited weight gain. Since then criticism has been leveled at the use of antibiotics at sub - therapeutic levels to promote growth and feed conversion efficiency. Although the recent demonstration that plasmid genes encoding for resistance are present in the environ ment and feces of swine and in carcasses there has been little evidence other than point - of - sale surveys that livestock are contributing to emerging drug resistance among bacterial pathogens affecting humans. Irrespective of the lack of firm scientific evi dence that the use of antibiotics in intensive livestock production is directly contributing to drug resistance in hospital and community settings there is a wide perception among consumers that lax regulation over sub - therapeutic administration to food an imals is deleterious to public health. Accordingly use of antibiotics for performance enhancement was banned in the EU in 2006 and in the US effective January 2017. Administration of antibiotics for therapy or prophylaxis is now strictly regulated in the E U and the U.S and subject to veterinary prescription applying Prudent Use Principles. Multiple stakeholders must be considered as food production responds to new legislation and rules to limit antibiotic use by farmers, producers, consumers, the medical pr ofession and veterinarians. This paper identifies possible replacement modalities that are acceptable to consumers and the food industry without detrimental effects on animal health and performance. The five criteria producers should consider before adopti ng alternatives to antibiotics are reviewed. Alternatives include but are not limited to probiotics, prebiotics, short and medium chain fatty ac ids, enzyme feed supplements, essential oils and botanicals. The paper stresses that no single additive will rep lace the declining benefits of sub - therapeutic administration of antibiotics. It will be necessary in the future to create programs with a holistic approach to replacement of antibiotics in conformity with EU and U.S. restrictions. Accordingly greater atte ntion should be applied to management, control of immunosuppressive viruses and protozoal parasites, nutrition and the selection of suitable genetic strains to achieve sustainable and safe production of livestock.
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Hedner, Ulla. „Factor VIIa and its potential therapeutic use in bleeding-associated pathologies“. Thrombosis and Haemostasis 100, Nr. 10 (2008): 557–62. http://dx.doi.org/10.1160/th08-07-0434.
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SummaryRecombinant FVIIa (rFVIIa) was developed for treatment of haemophilia patients with inhibitors against FVIII/FIX. The haemostatic efficacy rate of 80–90% including major orthopaedic surgery (dosing of 90–120 µg/kg every other hour [h] for at least the first 24 h) was achieved in these patients. In a home-treatment setting the efficacy rate of haemostasis in mild-moderate bleedings was 92% (average number of 90 µg/kg doses was 2.2). A wide individual variation regarding recovery of rFVIIa (46 ± 12%; median 43%) as well as of clearance rate (36 ± 8 ml/kg/h; median 32 ml/kg/h in adults;children 2–3 times higher) has been observed. Thus children may require higher doses than adults. Accordingly the use of a dose of 270 µg/kg in one single injection was approved in the EU. Recent experience indicates that repeated doses of rFVIIa may decrease the number of bleeds in “target joints”, and thus may be useful as prophylaxis in severe hemophilia with inhibitors. Pharmacological concentrations of rFVIIa have been shown to enhance the thrombin generation on thrombin activated platelets in a cell-based model. By doing so a tight structured fibrin haemostatic plug resistant against premature lysis is formed. rFVIIa has been shown to induce haemostasis not only in haemophilia but also in other situations characterized by an impaired thrombin generation such as platelet defects, dilution coagulopathy developed as a result of trauma and extensive surgery. A special form of profuse bleeding, that may cause extensive problems is postpartum haemorrhage.
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Díaz-García, Diana, Sanjiv Prashar und Santiago Gómez-Ruiz. „Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective“. International Journal of Molecular Sciences 24, Nr. 3 (25.01.2023): 2332. http://dx.doi.org/10.3390/ijms24032332.
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Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The versatility of these materials allows the design of a wide variety of platforms that can incorporate numerous agents of interest (fluorophores, proteins, drugs, etc.) in a single scaffold. However, the use of these systems loaded with metallodrugs as cytotoxic agents against different diseases and with distinct therapeutic targets has been studied to a much lesser extent. This review will focus on the work carried out in this field, highlighting both the pioneering and recent contributions of Spanish groups that have synthesized a wide variety of systems based on titanium, tin, ruthenium, copper and silver complexes supported onto nanostructured silica. In addition, this article will also discuss the importance of the structural features of the systems for evaluating and modulating their therapeutic properties. Finally, the most interesting results obtained in the study of the potential therapeutic application of these metallodrug-functionalized silica-based materials against cancer and bacteria will be described, paying special attention to preclinical trials in vivo.
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BJ, Pereira. „Therapeutic Approach to Erectile Dysfunction - News and Future Perspectives“. Open Access Journal of Urology & Nephrology 7, Nr. 1 (07.01.2022): 1–8. http://dx.doi.org/10.23880/oajun-16000201.
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Erectile dysfunction is defined as the inability to get or keep an erection that is sufficient for satisfactory sexual intercourse. It is one of the most prevalent sexual dysfunctions in men, usually correlated with aging. This pathology is generally associated with repercussions in the psychological and social well-being of the patient and his relationship with his partner. This way, it is considered an important cause of a decrease in quality of life. The treatments available today, in most cases, solve the symptoms, however, none of them can reverse the physiopathological basis of erectile dysfunction. In addition to that, they can also interfere with the spontaneity of sexual intercourse, which may be an obstacle to their use. The search for new therapeutic alternatives for erectile dysfunction is in constant development. As sexuality is an important element in human life, an update on these therapeutic advances becomes pertinent, since they could eventually change the paradigm of treatment of this pathology. This work aims to produce a review of the evidence on recent therapeutic advances in erectile dysfunction, as low-intensity shockwave therapy, botulinum toxin treatment, and platelet-rich plasma therapy. This way, a wide bibliography research will be conducted, through online databases and relevant manuscripts.
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Fielding, Burtram C., Carlos da Silva Maia Bezerra Filho, Nasser S. M. Ismail und Damião Pergentino de Sousa. „Alkaloids: Therapeutic Potential against Human Coronaviruses“. Molecules 25, Nr. 23 (24.11.2020): 5496. http://dx.doi.org/10.3390/molecules25235496.
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Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2.
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Bajan, Sarah, und Gyorgy Hutvagner. „RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs“. Cells 9, Nr. 1 (07.01.2020): 137. http://dx.doi.org/10.3390/cells9010137.
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The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to be a rapidly expanding market, as many emerging biopharmaceutical companies are developing RNA interference (RNAi)-based, and RNA-based antisense oligonucleotide therapies. However, miRNA therapeutics are noticeably absent. miRNAs are regulatory RNAs that regulate gene expression. In disease states, the expression of many miRNAs is measurably altered. The potential of miRNAs as therapies and therapeutic targets has long been discussed and in the context of a wide variety of infections and diseases. Despite the great number of studies identifying miRNAs as potential therapeutic targets, only a handful of miRNA-targeting drugs (mimics or inhibitors) have entered clinical trials. In this review, we will discuss whether the investment in finding potential miRNA therapeutic targets has yielded feasible and practicable results, the benefits and obstacles of miRNAs as therapeutic targets, and the potential future of the field.
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Varani, Michela, Valeria Bentivoglio, Chiara Lauri, Danilo Ranieri und Alberto Signore. „Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1)“. Biomolecules 12, Nr. 10 (20.10.2022): 1522. http://dx.doi.org/10.3390/biom12101522.
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The use of nanoparticles (NPs) is rapidly increasing in nuclear medicine for diagnostic and therapeutic purposes. Their wide use is due to their chemical–physical characteristics and possibility to deliver several molecules. NPs can be synthetised by organic and/or inorganic materials and they can have different size, shape, chemical composition, and char. These factors influence their biodistribution, clearance, and targeting ability in vivo. NPs can be designed to encapsulate inside the core or bind to the surface on several molecules, including radionuclides, for different clinical applications. Either diagnostic or therapeutic radioactive NPs can be synthetised, making a so-called theragnostic tool. To date, there are several methods for radiolabelling NPs that vary depending on both the physical and chemical properties of the NPs and on the isotope used. In this review, we analysed and compared different methods for radiolabelling NPs for single-photon emission computed tomography (SPECT) use.
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Pichini, Simona, Alfredo Fabrizio Lo Faro, Francesco Paolo Busardò und Raffaele Giorgetti. „Medicinal Cannabis and Synthetic Cannabinoid Use“. Medicina 56, Nr. 9 (07.09.2020): 453. http://dx.doi.org/10.3390/medicina56090453.
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Cannabis products have been used for centuries by humans for recreational and medical purposes. Resent research, proposed the promising therapeutic potential of cannabis and related cannabinoids for a wide range of medical conditions, including psychiatric and neurological diseases. This Special Issue presents the latest updates on medicinal cannabis and synthetic cannabinoids pharmacology, toxicology and new analytical methods to identify and quantify these compounds in conventional and non-conventional biological matrices. Moreover, it provides current data regarding their adverse effects, safety, application for medical purposes and their harmful effects.
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Balazs, Daniel A., und WT Godbey. „Liposomes for Use in Gene Delivery“. Journal of Drug Delivery 2011 (15.12.2011): 1–12. http://dx.doi.org/10.1155/2011/326497.
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Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.
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Gándara, Zoila, Noelia Rubio und Rafael R. Castillo. „Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems“. Pharmaceutics 15, Nr. 2 (20.01.2023): 351. http://dx.doi.org/10.3390/pharmaceutics15020351.
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The use of nanoparticles is crucial for the development of a new generation of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with a wide range of functional biopolymers with unique physicochemical properties thus providing several advantages: (1) limitation of interparticle interaction, (2) preservation of cargo and particle integrity, (3) reduction of immune response, (4) additional therapeutic effects and (5) cell targeting. Therefore, the engineering of advanced functional coatings is of utmost importance to enhance the biocompatibility of existing biomaterials. Herein we will focus on the most recent advances reported on the delivery and therapeutic use of silica-based nanoparticles containing biopolymers (proteins, nucleotides, and polysaccharides) with proven biological effects.
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Reva, Yana. „AESTHETIC AND THERAPEUTIC POTENTIAL CHOREOGRAPHY“. Aesthetics and Ethics of Pedagogical Action, Nr. 14 (09.09.2016): 184–91. http://dx.doi.org/10.33989/2226-4051.2016.14.171614.
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The article is about necessity of psyco-pedagogical attention to the problems of people psycophysical and emotional health saving. In order to get this difficult goal real, art of dance helps person to understand himself and leads to selfperfection. The dance is a merge of physical, psychological and esthetic activities. But the art of dance is also a therapeutic factor and its value is rising with developing of sangennic role of the art in modern life and in harmonization of Human-Universe relations.Functionality of dance art is quite wide. Thoughtful usage of dance impact leads to psychological and physical conditions stabilization and return of a person to harmonic life. Dance therapy is use of dance, plastic and rhythms for prophylactics and cure. So the objective of dance therapy is to establish a contact between a person and world. It could be done in parallel with language impact or without. Dance usage is based on the following: movement shows the person characteristics, its thoughts, mood, feelings, gained experience; combined elements of the movements make expressive dance with ability to self-expression. Dance therapy helps children to identify themselves and achieve better self-understanding. The objective of dance therapy is to destroy internal obstacles of child on its way to happiness and harmony.Also professional usage of dance therapy helps to stabilize child psychological condition and return it to normal life. That is why future dance teacher should pay attention to esthetic and therapeutic abilities of dance art and use them in their professional activities.
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Wadhwa, A., A. Sareen und Y. Saade. „TMS use in Depressive disorder in Youth“. European Psychiatry 65, S1 (Juni 2022): S739. http://dx.doi.org/10.1192/j.eurpsy.2022.1908.
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Introduction Trans-cranial magnetic stimulation (TMS) as a non-invasive method of altering brain activity (1) has widened the array of therapeutic options available for various psychiatric disorders. Objectives Trans-cranial Magnetic stimulation (TMS) as a non-invasive method of altering brain activity has widened the array of therapeutic options available for various psychiatric disorders. •A large number of studies have shown therapeutic benefits in a wide range of patient population with majority of studies in adults. •TMS is used increasingly for the treatment of child and adolescent depression. •Yet, the scarcity of studies and lack of published guidelines for this population is notable. •As TMS use is expanding in this population, an overview of the use of TMS in children and adolescents with depression may provide much needed and timely perspective on this neuropsychiatric intervention. Methods We searched all published studies using PubMed database, on TMS use in depressive disorders in children and adolescents. A total of 13 studies were found to have reported use of TMS in depression in children and adolescents. Results We found various case series, open label studies as well as sham controlled blind studies indicating that TMS has been effective in treating depression in children and adolescents. No significant side effects were found in our review. Conclusions Studies have shown that TMS is an effective treatment option for depressive disorders in children and adolescents. Initial studies look promising but implications in large pediatric population may be different and there is a need for more double blind, controlled trials with larger sample size. Disclosure No significant relationships.
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Rusconi, Christopher, Bruce Sullenger und Richard Becker. „Nucleic acid aptamers in therapeutic anticoagulation“. Thrombosis and Haemostasis 93, Nr. 06 (2005): 1014–20. http://dx.doi.org/10.1160/th04-12-0790.
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SummaryThe evolution of anticoagulant therapy for the prevention and treatment of thrombotic disorders has progressed at a relatively modest pace considering the scope of the problem and our current understanding of platelet biology, coagulation proteases, and vascular science as they apply to protective haemostasis and pathologic thrombosis. Recent observations, dedicated to cellular-based models of coagulation, provide fundamental constructs, mechanistic clarity, and potentially unparalleled opportunity for accelerating the development and wide-scale clinical use of safe, effective, regulatable and patient-specific therapies. The following review introduces a novel domain of anticoagulant therapy referred to as aptamers (derived from the Latin aptus – to fit), considering their history, development, and potential application in patient care arenas.
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Valko, Peter C., Jack P. Campbell, David L. McCarty, Dennis Martin und Joe Turnbull. „Prehospital Use of Pulse Oximetry in Rotary-Wing Aircraft“. Prehospital and Disaster Medicine 6, Nr. 4 (Dezember 1991): 421–28. http://dx.doi.org/10.1017/s1049023x00038905.
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AbstractA prospective study of 200 patients was conducted to evaluate the use of pulse oximetry as an adjunct to clinical monitoring of critically ill patients transported by rotary-wing aircraft with non-pressurized cabins. Thirty-four subjects (17%) were found to have significant hemoglobin desaturation of less than 90%, as defined by pulse oximetry (SpO2). Data were recorded continuously for later review. Desaturation often was noted prior to alterations in vital signs or clinical appearance. In 32 of the 34 hypoxemic subjects (94%), therapeutic interventions corrected the low SpO2. The use of pulse oximetry permitted measures for cardiorespiratory support to be instituted and assessed more rapidly than otherwise would have been possible. The availability of a continuous record of SpO2 facilitated detailed review of case management. It is concluded that the use of pulse oximetry is a practical and valuable adjunct for monitoring critically ill patients transported by rotary-wing aircraft.
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Lavorini, Federico. „The Challenge of Delivering Therapeutic Aerosols to Asthma Patients“. ISRN Allergy 2013 (05.08.2013): 1–17. http://dx.doi.org/10.1155/2013/102418.
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The number of people with asthma continues to grow around the world, and asthma remains a poorly controlled disease despite the availability of management guidelines and highly effective medication. Patient noncompliance with therapy is a major reason for poor asthma control. Patients fail to comply with their asthma regimen for a wide variety of reasons, but incorrect use of inhaler devices is amongst the most common. The pressurised metered-dose inhaler (pMDI) is still the most frequently used device worldwide, but many patients fail to use it correctly, even after repeated tuition. Breath-actuated inhalers are easier to use than pMDIs. The rationale behind inhaler choice should be evidence based rather than empirical. When choosing an inhaler device, it is essential that it is easy to use correctly, dosing is consistent, adequate drug is deposited in both central and peripheral airways, and that drug deposition is independent of airflow. Regular checking of inhalation technique is crucial, as correct inhalation is one of the cornerstones of successful asthma management.
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Washburn, Nathaniel, Inessa Schwab, Daniel Ortiz, Naveen Bhatnagar, Jonathan C. Lansing, Amy Medeiros, Steven Tyler et al. „Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity“. Proceedings of the National Academy of Sciences 112, Nr. 11 (02.03.2015): E1297—E1306. http://dx.doi.org/10.1073/pnas.1422481112.
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Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain major limitations for patients and physicians using IVIg. These limitations have stimulated a desire to generate therapeutic alternatives that could leverage the broad mechanisms of action of IVIg while improving therapeutic consistency and potency. The identification of the important anti-inflammatory role of fragment crystallizable domain (Fc) sialylation has presented an opportunity to develop more potent Ig therapies. However, translating this concept to potent anti-inflammatory therapeutics has been hampered by the difficulty of generating suitable sialylated products for clinical use. Therefore, we set out to develop the first, to our knowledge, robust and scalable process for generating a well-qualified sialylated IVIg drug candidate with maximum Fc sialylation devoid of unwanted alterations to the IVIg mixture. Here, we describe a controlled enzymatic, scalable process to produce a tetra-Fc–sialylated (s4-IVIg) IVIg drug candidate and its qualification across a wide panel of analytic assays, including physicochemical, pharmacokinetic, biodistribution, and in vivo animal models of inflammation. Our in vivo characterization of this drug candidate revealed consistent, enhanced anti-inflammatory activity up to 10-fold higher than IVIg across different animal models. To our knowledge, this candidate represents the first s4-IVIg suitable for clinical use; it is also a valuable therapeutic alternative with more consistent and potent anti-inflammatory activity.
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Vidal, Enrico, Francesco Garzotto, Mattia Parolin, Chiara Manenti, Anna Zanin, Massimo Bellettato, Giuseppe Remuzzi, Stuart L. Goldstein, Luisa Murer und Claudio Ronco. „Therapeutic Plasma Exchange in Neonates and Infants: Successful Use of a Miniaturized Machine“. Blood Purification 44, Nr. 2 (2017): 100–105. http://dx.doi.org/10.1159/000470827.
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Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinemia being the most notable exception. The only alternative to TPE in small pediatric patients is manual blood exchange transfusion, which, however, bears an unacceptably high risk of severe complications. Still, technical issues due to extracorporeal circulation in neonates have burdened TPE so far, since machines developed for adults require a relatively large blood volume to operate. We in this study, describe our preliminary experience of TPE for treating 2 potentially life-threatening conditions in neonatal age. To overcome the aforementioned limitations, plasmapheresis was performed in both cases using a machine specifically designed for patients weighing less than 10 kg.
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Marson, Justin, und Mark Lebwohl. „Apremilast as an Off-Label Therapeutic Agent“. SKIN The Journal of Cutaneous Medicine 5, Nr. 3 (17.05.2021): 203–27. http://dx.doi.org/10.25251/skin.5.3.2.
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Objective: To review the literature regarding the efficacy and safety of off-label use of apremilast in combination therapies for psoriasis and psoriatic arthritis and for other currently off-label inflammatory dermatoses. Methods: The Medline database was queried for all relevant articles published between 2014 and 2021 using exploded MeSH terms and keywords pertaining to the following themes: off-label, combination therapy, biologics, biologic therapy, methotrexate, and systemic psoriasis therapy. The Boolean term “AND” was used to find the intersection of these themes with the term “apremilast.” Results: 8 case series and 6 case reports investigated the use of apremilast in combination therapy for psoriasis and psoriatic arthritis. Addition of apremilast improved PASI scores by 31.8-77.4% among case series and 80-100% among case reports with adverse effects primarily consisting of gastrointestinal symptoms. 5 randomized-control trials (RCT), 9 open-label trials, 18 case series, and 30 case reports investigated the use of apremilast for off-label dermatoses. In RCTs, apremilast showed potential efficacy for atopic dermatitis and hidradenitis suppurativa. Open-label trials found apremilast efficacious for atopic dermatitis, allergic contact dermatitis, chronic pruritus, cutaneous sarcoidosis, discoid lupus erythematosus, hidradenitis suppurativa, lichen planus, prurigo nodularis, rosacea, and vitiligo. Limitations: Small sample size and short follow duration up for available randomized-control and open-label trials. Current data from case series/reports potentially limits generalizability of findings. Conclusion: Apremilast's safety profile makes it a potential efficacious, non-biologic systemic agent for monotherapy and combination therapy for a wide range of inflammatory dermatoses.
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Lewis, Jamal S., und Riley P. Allen. „An introduction to biomaterial-based strategies for curbing autoimmunity“. Experimental Biology and Medicine 241, Nr. 10 (Mai 2016): 1107–15. http://dx.doi.org/10.1177/1535370216650294.
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Recently, scientists have made significant progress in the development of immunotherapeutics that correct aberrant, autoimmune responses. Yet, concerns about the safety, efficacy, and wide scale applicability continue to hinder use of contemporary, immunology-based strategies. There is a clear need for therapies that finely control molecular and cellular elements of the immune system. Biomaterial engineers have taken up this challenge to develop therapeutics with selective spatial and temporal control of immune cells. In this review, we introduce the immunology of autoimmune disorders, survey the current therapeutic strategies for autoimmune diseases, and highlight the ongoing research efforts to engineer the immune system using biomaterials, for positive therapeutic outcomes in treatment of autoimmune disorders.
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Adamski, Jill. „Thrombotic microangiopathy and indications for therapeutic plasma exchange“. Hematology 2014, Nr. 1 (05.12.2014): 444–49. http://dx.doi.org/10.1182/asheducation-2014.1.444.
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Abstract Thrombotic microangiopathy (TMA) is a clinicopathological condition associated with a wide variety of medical conditions. TMA is classically characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombi that cause end-organ damage. The most prominent diagnoses associated with TMA are thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Although TTP and HUS can have similar clinical and laboratory features and are often lumped together as a combined entity referred to as “TTP/HUS,” the pathologic processes causing TMA and optimal therapies for these conditions are different. Empiric use of therapeutic plasma exchange (TPE) in the setting of TMA is common. The high risk of morbidity and mortality associated with some causes of TMA justify rapid institution of this relatively low-risk procedure. However, many causes of TMA do not respond to TPE and prolonged courses of exchange in the absence of an underlying diagnosis may cause a detrimental delay in appropriate medical therapy. The American Society of Apheresis has published guidelines for the use of TPE for several distinct conditions associated with TMA. This list is not comprehensive and the use of TPE for other causes of TMA may be considered if the mechanism of the underlying disease process provides a clear rationale for this intervention.
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Chen, Youdong, Qian Yu, Yifan Hu und Yuling Shi. „Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases“. Current Stem Cell Research & Therapy 14, Nr. 7 (23.09.2019): 579–82. http://dx.doi.org/10.2174/1574888x14666190429141421.
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: Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal, multipotent non-hematopoietic stem cells, which display profound immunomodulatory functions and promising therapeutic effects. Autoimmune diseases, which result from an aberrant immune response to selfantigens, can be detrimental to nearly all body tissues. With the advance in developing a novel treatment, including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate the remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In this review, the immunomodulatory influence of MSCs over immune cells and the application of MSCs transplantation in treating autoimmune diseases are highlighted.
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Shahriar, S., Jagannath Mondal, Mohammad Hasan, Vishnu Revuri, Dong Lee und Yong-Kyu Lee. „Electrospinning Nanofibers for Therapeutics Delivery“. Nanomaterials 9, Nr. 4 (03.04.2019): 532. http://dx.doi.org/10.3390/nano9040532.
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The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications.
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Karki, Karuna T., Pramod K. Chaudhary, Binod Bhattarai und Sunil Munakomi. „Complex Cerebrovascular Presentation in Central Nepal with Therapeutic Challenge“. Nepal Journal of Neuroscience 12, Nr. 2 (08.10.2016): 73–80. http://dx.doi.org/10.3126/njn.v12i2.15898.
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Effective management of complex vascular malformation remains one of the more challenging problems faced in most of the developing countries where modern therapeutic resources are deficient. Giant arteriovenous malformations and other vascular malformation like dural arteriovenous malformations are often associated with higher morbidity and mortality rates. These lesions are considered as untreatable or inoperable. Endovascular therapy is an expanding science for managing complex vascular malformations in Nepal that has many constraints. This outset will have positive impact in the country that has to deal with moderate resources to provide wide therapeutic benefit. Here we present our preliminary experience about the use of ethylene vinyl alcohol (Onyx- 18) to embolize dural arteriovenous fistula and use of n-butyl cyanoacrylate to embolize giant supratentorial arteriovenous malformation.Nepal Journal of Neuroscience 12:73-80, 2015
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Tsibulkina, V. N. „Leading mechanisms of the therapeutic effect of dimephosphone“. Kazan medical journal 80, Nr. 2 (25.03.1999): 120–22. http://dx.doi.org/10.17816/kazmj66460.
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A wide range of clinical efficiency of dimephosphone a home-made low-toxic organic phosphonis drug supposes its effect on the processes universal for most cellular systems. The basis of the leading mechanisms of effect of the drug is antagonism to calcium-dependent processes of the intracellular transfer of excitation. The concept of the therapeutic effect of dimephosphone on the basis of antiinflammatory, antihistaminic and antiagrega-tional properties with the recommendation to comprehensive use according to new indications in patients with chronic urticaria and acute erosive and ulcerous processes of gastroenteric tract is developed.
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Walsh, David A., und Joanne Stocks. „New Therapeutic Targets for Osteoarthritis Pain“. SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, Nr. 8 (06.07.2017): 931–49. http://dx.doi.org/10.1177/2472555217716912.
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Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all joints. Current pharmacological analgesics have limited efficacy, and their use is often restricted by adverse events. Medications that might reduce pain by slowing or preventing structural disease remain elusive. Our increasing understanding of the complex mechanisms that underlie OA pain offers a wide range of potential new treatment targets. New drugs for OA pain might come from repurposing those developed for other conditions, as well as novel compounds targeting pain mechanisms specific to the joint. Here we discuss the mechanisms of OA pain and its therapeutic implications. We explore evolving treatment modalities, including combination treatment. We review recent research and patents pointing to future OA therapies. We discuss the potential for biomarkers to facilitate drug development and targeting.
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Giovati, Laura, Tecla Ciociola, Tiziano De Simone, Stefania Conti und Walter Magliani. „Wickerhamomyces Yeast Killer Toxins’ Medical Applications“. Toxins 13, Nr. 9 (15.09.2021): 655. http://dx.doi.org/10.3390/toxins13090655.
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Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by Wickerhamomyces anomalus and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs and their use as potential anti-infective therapeutics. Studies on immunological derivatives of KTs in the context of vaccine development are also described.
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Khalid, Husna, Muneeba Rafique, Aimen Qaiser, Fakhar-Ud-Din und Gul Shahnaz. „Carbon Nanotubes: A Brief Review on Its Use for Biomedical Imaging Purpose“. Global Drug Design & Development Review IV, Nr. I (30.12.2019): 24–33. http://dx.doi.org/10.31703/gdddr.2019(iv-i).03.
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Carbon nanotubes (CNTs) belong to the fullerene family, also known as graphene. These graphenes are similar to the graphite sheets and when these are turn up in the cylindrical form they are known as carbon nanotubes. Currently, the most common methods used for CNTs preparation are: Electric-arc-discharge methods, Chemical-vapor-deposition method and Laserablation method. In order to cross the cell membrane, functionalization of the pristine CNTs is performed. Because of the sp2 hybridization and closely packed hexagons in their structure, functionalization of the pristine CNTs can be done easily with either therapeutic agent or the imaging agent. They have wide applications in the field of bio-imaging because of their intrinsic optical, mechanical and electrical properties. They can be used as efficient contrast agents and the biosensors as well as efficient carriers for the delivery of therapeutic or imaging agents.
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Capasso, Raffaele, und Lorenzo Di Cesare Mannelli. „Special Issue “Plant Extracts: Biological and Pharmacological Activity”“. Molecules 25, Nr. 21 (04.11.2020): 5131. http://dx.doi.org/10.3390/molecules25215131.
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Georgianos, Panagiotis I., Vasilios Vaios, Theodoros Eleftheriadis, Evangelos Papachristou und Vassilios Liakopoulos. „Therapeutic Advances in Diabetic Kidney Disease“. International Journal of Molecular Sciences 24, Nr. 3 (01.02.2023): 2803. http://dx.doi.org/10.3390/ijms24032803.
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Although sodium glucose co-transporter type 2 (SGLT-2) inhibitors were initially introduced as glucose-lowering medications, it was later discovered that cardiorenal protection is the most important treatment effect of these agents. A triad of landmark trials consistently showed the benefits of SGLT-2 inhibitors on kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD), irrespective of the presence or absence of Type 2 diabetes (T2D). Furthermore, finerenone is a novel, selective, nonsteroidal mineralocorticoid receptor antagonist (MRA) that safely and effectively improved cardiorenal outcomes in a large Phase 3 clinical trial program that included >13,000 patients with T2D and a wide spectrum of CKD. These two drug categories have shared and distinct mechanisms of action, generating the hypothesis that an overadditive cardiorenal benefit with their combined use may be biologically plausible. In this article, we describe the mechanism of action, and we provide an overview of the evidence for cardiorenal protection with SGLT-2 inhibitors and the nonsteroidal MRA finerenone in patients with CKD associated with T2D.
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Bounid, Oumayma, Tariq Igarramen, Youness El-Khadir, Rokkaya Iharti, Ghita Hadraoui, Sanae Chaouia, Mouna Darfaoui, Abdelhamid El Omrani und Mouna Khouchani. „Therapeutic Management of Hidradenocarcinoma: Case Report and Literature Review“. Scholars Journal of Medical Case Reports 9, Nr. 8 (05.08.2021): 757–59. http://dx.doi.org/10.36347/sjmcr.2021.v09i08.003.
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Hidradenocarcinoma is a rare and aggressive carcinoma arising from sweat glands that manifests as an asymptomatic, slow-growing skin tumor. It metastasizes to regional lymph nodes and distant viscera. We report a case of 77 years old man who presented with an invasive hidradenocarcinoma of the scalp without lymph node involvement, treated by wide local excision and Post-operative radiotherapy. The management of this rare entity is not yet well defined. The results are still poor despite the use of multiple treatment modalities.
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Loebinger, Michael R., Susana Aguilar und Sam M. Janes. „Therapeutic potential of stem cells in lung disease: progress and pitfalls“. Clinical Science 114, Nr. 2 (11.12.2007): 99–108. http://dx.doi.org/10.1042/cs20070073.
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There has been increasing excitement over the last few years with the suggestion that exogenous stem cells may offer new treatment options for a wide range of diseases. Within respiratory medicine, these cells have been shown to have the ability to differentiate and function as both airway and lung parenchyma epithelial cells in both in vitro and increasingly in vivo experiments. The hypothesis is that these cells may actively seek out damaged tissue to assist in the local repair, and the hope is that their use will open up new cellular and genetic treatment modalities. Such is the promise of these cells that they are being rushed from the benchside to the bedside with the commencement of early clinical trials. However, important questions over their use remain and the field is presently littered with controversy and uncertainty. This review evaluates the progress made and the pitfalls encountered to date, and critically assesses the evidence for the use of stem cells in lung disease.
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Stefania, Silvia, Ripalta Colia, Rotondo Cinzia, Addolorata Corrado und Francesco Paolo Cantatore. „Off-label use of anti-IL-1 drugs in rheumatic diseases“. International Journal of Immunopathology and Pharmacology 35 (Januar 2021): 205873842110065. http://dx.doi.org/10.1177/20587384211006584.
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Interleukin-1 (IL-1) plays a key role in the pathogenesis of different rheumatic diseases. There are now several agents available on the market capable of blocking IL-1. The proven effectiveness and excellent safety of these drugs makes them a possible therapeutic option in the treatment of IL-1 driven diseases, when previous therapies are contraindicated or ineffective. This article discusses the European wide off-label use of these drugs for the treatment of rheumatic diseases.