Dissertationen zum Thema „T4t“
Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an
Machen Sie sich mit Top-50 Dissertationen für die Forschung zum Thema "T4t" bekannt.
Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.
Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.
Sehen Sie die Dissertationen für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.
Cabeça, Maria Antónia Augusta. „Tit for tat em adolescentes“. Master's thesis, Instituto Superior de Psicologia Aplicada, 1996. http://hdl.handle.net/10400.12/373.
Der volle Inhalt der QuelleChattha, Jawwad Nasar. „Characterization of Selfish Behavior in Mobile Ad Hoc Networks through Virtual Emulation“. Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34666.
Der volle Inhalt der QuelleOur work involves characterizing selfish behavior by nodes in ad hoc networks and assessing the effectiveness of adopting tit for tat based strategies, which are meant to discourage selfish behavior in the network. We show that in an ad hoc network where other nodes act selfishly to conserve their resources, a node can benefit by adopting a generous tit for tat strategy. We also show that a node can gain benefit by avoiding selfish nodes in an ad hoc network, adopting a strategy that we call generous tit for tat with selfish avoidance (GTFT-SA).
To analyze the effectiveness of cooperation strategies in selfish ad hoc networks we create an emulation environment based on virtualization. Such an emulation environment is more flexible to changes and is simpler to replicate than real life testbeds, while providing higher fidelity than simulations.
Master of Science
Modin, Felicia. „An Analysis of Tit for Tat in the Hawk-Dove Game“. Thesis, Mälardalens högskola, Akademin för utbildning, kultur och kommunikation, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-54599.
Der volle Inhalt der QuelleClick, Ivy A., Abbey K. Mann, Morgan Buda, Anahita Rahimi-Saber, Abby Schultz, K. Maureen Shelton und Leigh Johnson. „Transgender Health Education for Medical Students“. Digital Commons @ East Tennessee State University, 2019. https://doi.org/10.1111/tct.13074.
Der volle Inhalt der QuellePATRIZI, LODOVICO. „La chirurgia mininvasiva dell’incontinenza urinaria da sforzo femminile sintomatica: studio randomizzato TVT (transvaginal tape) vs. TOT (transobturator tape)“. Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/450.
Der volle Inhalt der QuelleObjective: The aim of our study was to compare tension-free vaginal (TVT) vs. trans-obturator tape (TOT) technique on a double blind randomised trial to evaluate cure rates, complications, overall satisfaction rates and after stratification according to symptoms severity. Methods: We recruited all patients affected by symptomatic SUI grade 1 and 2 and Q tip test > I. Exclusion criteria consisted in patients with SUI grade 3, Q tip test =1, urge incontinence, associated prolapses, neurovegetative disorders, previous surgery for SUI or under rehabilitative or medical therapies. SUI grade of severity was recorded as well as clinical data. Patients were randomized to receive TOT or TVT and results assessed at one month and one year. Results: We analysed 104 women. Significant differences were found between TOT and TVT groups regarding the operating times, number of catheterization days, postoperative pain (all greater for TVT; p<0.05). Although postoperative complications, recurrences and reoperations were similar among techniques, patients’ satisfaction rates at one month and one year were significant different when analysed according to the severity of SUI: SUI 1 patients appreciated more the TOT operation and SUI 2 patients more the TVT (p<0.001). Conclusions: The choice of TOT vs. TVT is not completely similar. According to satisfaction rates, TOT could be more indicated in SUI 1 and TVT in SUI 2. Although recurrences or bladder obstructions rates are not different among techniques, they can influence patients’ satisfaction and could be avoided with accurate and proper indications according to the SUI severity.
Linkevičius, Marius. „Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli“. Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259226.
Der volle Inhalt der QuelleTsang, P. (Poying). „Nestling growth and breeding biology of great tit, blue tit, willow tit and crested tit“. Master's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201805312306.
Der volle Inhalt der QuelleDAVEL, JAN L. „BIODEGRADATION OF THE ENERGETIC COMPOUNDS TNT, RDX AND HMX IN FLUIDIZED-BED AND ACTIVATED SLUDGE REACTORS“. University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1035234722.
Der volle Inhalt der QuelleBarrus, David R. „FIRM BIDDING BEHAVIOR IN HIGHWAY PROCUREMENT AUCTIONS: AN ANALYSIS OF SINGLE-BID CONTRACTS, TACIT COLLUSION, AND THE FINANCIAL IMPACT ON KENTUCKY“. UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/191.
Der volle Inhalt der QuelleMammadova, Nayiba. „Eléments de description et documentation du tat de l'Apshéron, langue iranienne d'Azerbaïdjan“. Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCF016/document.
Der volle Inhalt der QuelleThis thesis is a descriptive grammar of Tat (an Iranian language of the South-Western branch) as spoken on the Absheron Peninsula, east of Baku in the Republic of Azerbaijan. It is the first description of a Muslim variety of Tat in a Western European language.After a detailed introduction outlining the sociolinguistic context and the phonology, the present study discusses the parts of speech, the marking of grammatical relations and verbal morphology of Absheron Tat (verbal derivation, verb classes, complex predicates, formation and use of inflected verb forms). This is followed by a survey of complex sentences, viz. relative clauses, complement clauses, adverbial subordinates as well as coordination.The present work adopts a typological point of view and is based on the analysis of texts originating from the author’s fieldwork and tales translated from Azeri into Tat, in addition to the author’s competence as a native speaker. The appendix presents samples of the text corpus (some of them also translated) and a glossary listing items that feature in the grammatical description and the texts
Nielsen, Finn Sivert. „Eye of the whirlwind Russian identity and Soviet nation-building. Quests for meaning in a Soviet metropolis /“. Click here to access, 1987. http://www.anthrobase.com/Txt/N/Nielsen_F_S_03.htm.
Der volle Inhalt der QuelleIncludes bibliographical references (p. 320-336). Also available in print.
Jiang, Long. „TMT diversity, CEO procedural fairness, and TMT conflict“. College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3647.
Der volle Inhalt der QuelleThesis research directed by: Business and Management. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Guillo, Éric Démaria Fabien Arnaud Stéphane. „Résultats cliniques et fonctionnels du traitement de l'incontinence urinaire à l'effort par la voie rétro-pubienne (TVT) et trans-obturatrice (TOT et TVT-O) en cas d'insuffisance sphinctérienne (PCUM<30cmH2O) étude comparative chez 162 patientes /“. Créteil : Université de Paris-Val-de-Marne, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0488096.pdf.
Der volle Inhalt der QuelleCelona, Diana. „Synthesis of molecules with potential antiaggregation activity of beta-amyloid in alzheimer's disease“. Doctoral thesis, La Sapienza, 2005. http://hdl.handle.net/11573/917342.
Der volle Inhalt der QuelleMediouni, Sonia. „Etude par des anticorps de patients VIH-1 de la protéineTAT extracellulaire et développement thérapeutique“. Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20712.
Der volle Inhalt der QuelleThe protein Tat (Trans-activator of transcription) is definitely one of the most interesting targets in the fight against HIV-1. Synthesized early, it plays a central role in the viral life cycle and protects infected cells. Secreted into the extracellular medium, it participates in the immunodeficiency by inhibiting some functions or inducing apoptosis of immune cells. It is also directly involved in many diseases associated with HIV-1. In a first study, we examined whether HAART was able to inhibit the synthesis and secretion of the Tat protein. We proposed to HIV-1 infected patients under HAART, with undetectable viral load, to allow us to do five blood samplings (one every three months for one year) to verify the presence of antibodies against Tat. We found that 86% of patients had antibodies against Tat but these antibodies could disappear or appear in a majority of patients showing that Tat protein continues to be secreted in spite of antiviral treatment. A second study of patient sera was carried out to determine if Tat was structured in the blood of patients. There was a controversy in the literature about the fact that Tat could be naturally unstructured. We showed that Tat is structured in the serum of patients. In addition, the biological activity of Tat is closely related to the acquisition of its conformation. As part of a clinical development of a Tat vaccine in the laboratory, we carried out vaccinations in mice to determine the dose, the adjuvant, the route of administration, the number of boosts, tolerance and toxicity of the vaccine. Clinical trials are planed with a therapeutic protocol. The laboratory is also developing another therapeutic approach with a mouse monoclonal antibody able to recognize and neutralize Tat variants representative of the five major subtypes of HIV-1. This antibody will be humanized and could be used for future immunotherapy, in combination with HAART for patients in early or late stage of the pathology or to newborn babies who have a weak immune system
Bonet, Pilar 1956. „ADLAN i el Club 49. Tot muda i tot roman“. Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/672749.
Der volle Inhalt der QuelleIn 1932 in Barcelona, during the euphoric republican era, a group of friends created the cultural association ADLAN (Amics de l'Art Nou). Up until the civil war they undertook many activities in the field of the arts, literature, photography, cinema, music, dance, arquitecture and popular arts. Always foliowing their criticar espirit, they participated in artistic debates being leaders of the surrealistic poetry and the defense of the popular arts. They built a community that joined Barcelona with París, Madrid and Tenerife. Part of this group, whose leader was Joan Prats, re-started their activities in 1949, creating the association Club 49. Once again, the civil society that they represented was responsible for generating a most progressive and innovative culture, during the worst years of the Franco government, of abstract art, jazz, contemporany music, escenic poetry, improvised theatre or art education. They were the protagonists of an important part of the contemporany catalan culture, always with the most heterodox creations and with a vitality born of their entusiasm, friendship and crltical capacity. Among them, Joan Prats, Joan Miró, Angel Ferrant, Robert Gerhard, Sebastia Gasch, Joaquim Gomis, Eudald Serra, Magí A. cassanyes, J.V. Foix, Alexandre Cirici Pellicer, Antoni Tapies, Joan Brossa, Josep M. Mestres Quadreny, Miquel Porter, Ricard Gomis, Josep Lluis Sert, Joaquim Homs, and many more. This research documents and contextualises the activíties that both associations conducted , analysing the events and debates in which they participated . Beyond the important names involved, the research focusses on their existence as an intelectual community, on their vislon of art as a critica! channel and on their wish to live the present as an opportunity to built a future. The spirit and the activlties of this civil society allow us to interpret the history of Catalan art from a perspectíve of the XXI century.
Salomão, Karina Bezerra. „Estudo da expressão dos genes TETs e níveis de hidroximetilação em meduloblastoma“. Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-18042018-104554/.
Der volle Inhalt der QuelleMedulloblastoma (MB) is an embryonic tumor that originates from genetic alterations in pathways that are important to the neurogenesis of cerebellum, such as Sonic hedgehog (Shh) e Wingless (Wnt). These alterations allow us to classify MB based in expression and mutational profile in four subgroups: SHH, WNT, group 3 and group 4. The activation of these pathways could be related to hypermethylation of negative regulators. Hydroxymethylation dynamics was described during cerebellum development, but there are not reports in the literature about hydroxymethylation levels in MB samples. The main aims of this study were: to evaluate TET and IDH genes expression in MB using qPCR; to investigate hydroxymethylation levels using immunohistochemistry and dot-blot; to evaluate mutations in exon 4 of IDH1 and IDH2 genes through sequencing analysis; to analyze methylation and hydroxymethylation levels in genes that regulate SHH, WNT, NOTCH and BMP pathways; to modulate TET genes activity through ascorbic acid and verify its functional and epigenetic influence in MB cell lines. We observed a decrease in TET and IDH genes expression in MB samples compared to fetal cerebellum, but not according to non-fetal cerebellum. MB cell lines presented a decrease when compared to both control groups. The classification of MB samples allowed us to verify a subgroup-specific gene expression. TET3 expression was associated with disease status; and higher levels of IDH2 gene expression were associated with metastasis. We did not find mutations in exon 4 of IDH1 and exon 4 of IDH2 genes in MB samples. Hydroxymethylation levels were decreased in MB samples and cell lines when compared to non-neoplastic cerebellum; however, they were not associated with clinical characteristics of the patients. We did not detect hydroxymethylation levels in the studied genes. Ascorbic acid effects are cell linespecific: we did not observe increase in hydroxymethylation levels, but alterations in TET3 gene expression. In conclusion, hydroxymethylation and expression levels of TET and IDH genes are important for MB. Though, functional assays that target these genes are required to elucidate their function in MB.
Geisler, Oliver. „Areale der Tat“. Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-97332.
Der volle Inhalt der QuelleMarketing, Corporate Affairs and. „Rhythm, Vol.2 No.1, 07/2005“. Corporate Affairs and Marketing, 2005. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000668.
Der volle Inhalt der QuelleFahrenfeld, Nicole Leah. „Fate of 2,4,6-trinitrotoluene (TNT) in historically contaminated aquifer sediments“. Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/37811.
Der volle Inhalt der QuellePh. D.
Chopard, Christophe. „Régulations de la sécrétion et de l’activité biologique de la protéine Tat du VIH-1 : rôles de la palmitoylation et de Gag“. Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20089/document.
Der volle Inhalt der QuelleHIV-1 Tat is a small protein that is required for viral transcription and multiplication. It thus has a crucial role in the infected cell. It was known that Tat can be secreted despite its lack of signal sequence. In fact 2/3 of cellular Tat are exported by infected primary T-cells. The unconventional secretion of Tat relies on its interaction with phosphatidylinositol(4,5)-biphosphate or PI(4,5)P2, a lipid that is concentrated within the inner leaflet of the plasma membrane and is strictly required for Tat secretion. Exogenous Tat has deleterious effects on several cell types, indicating that extracellular Tat is involved in evolution to AIDS. Consistent with this secretion efficiency, Tat is mainly localized at the plasma membrane of primary T-cells infected by HIV-1. A large fraction of Tat is resident at the membrane and we looked for a mechanism that could explain this retention and discovered that Tat is palmitoylated. Our studies show that Tat is palmitoylated, both in T-cells and also in ‘target' cells such as neurons and macrophages. Tat palmitoylation inhibits its secretion and is performed on Tat cysteine 31 (Tat has seven cyteines) by the enzyme DHHC20 using immunophilins (prolyl ismerases), Cyclophilin A (CypA) and FKPB12, as cofactors. Our results also indicate that the presence of Gag inhibits Tat palmitoylation. We believe that the export of CypA due to its encapsidation will make less CypA available for Tat, thereby inhibiting Tat palmitoylation. Indeed, HIV-1 encapsidates 250 copies of CypA/virion and the amount of CypA regulates the virulence of produced virions. In target cells, Tat is strongly palmitoylated and this modification induces its almost irreversible binding to PI(4,5)P2, preventing its secretion and allowing cumulative effect of minute Tat doses.Tat palmitoylation enables Tat to severely inhibit various PI(4,5)P2-dependent processes such as phagocytosis and neurosecretion. These effects of extracellular Tat likely contribute to the development of opportunistic infections and neurological disorders observed during AIDS
Kan, Fredericus Jacobus Wilhelmus van. „Sleutels tot de macht : de ontwikkeling van het Leidse patriciaat tot 1420 /“. Hilversum : Verloren, 1988. http://catalogue.bnf.fr/ark:/12148/cb37148515p.
Der volle Inhalt der QuelleDelhey, J. Kaspar V. „Sexual selection and blue tit (Parus caeruleus) crown coloration“. Diss., Connect to this title online, 2005. http://edoc.ub.uni-muenchen.de/archive/00004716/.
Der volle Inhalt der QuelleGorgels, A. P. M. „Van ziekteleer tot ziektebeheer“. Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 2005. http://arno.unimaas.nl/show.cgi?fid=12779.
Der volle Inhalt der QuelleBriant, Nicolas. „Devenir et biodisponibilité du Cu, Zn et TBT dans un environnement portuaire fortement contaminé : la marina de Port Camargue“. Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20120/document.
Der volle Inhalt der QuelleThe Mediterranean coastal area, particularly harbors and marinas represent areas of high pollution associated with population density and activity. They are also places of refuge for many aquatic species. Preliminary studies have shown that sediments from Port Camargue subject to mandatory dredging, present an important level of copper and organotins (OTs) contamination which can affect aquatic ecosystems. In this context, the objectives of this thesis are to characterize the state of contamination in sediments and the water column, the impact of this contamination on target organisms, and identify the processes that control the dynamics of pollutants in the sedimentary column and sediment/water interface. To achieve the objectives, the study coupled in situ approach (core samples, sampling of interstitial water at the interface, caging deployment…) and a laboratory in vitro approach (sorption tests in microcosms). For this study the contamination of the sediment (particulate and dissolved phases) was performed in a first part. Secondly, the speciation of Cu, Zn and Mn as well as OSn in the harbor water was studied over a period of one year before dredging and for the six months during the dredging operations. The effects of contamination were also examined on bivalves (Ruditapes and Loripes) immersed in the water column. Finally, the copper isotopes as tracers of source of contamination were tested in this simple environment, since anthropogenic Cu comes mainly from antifouling paints. The entire study has provided insight into the future, the dynamic and bioavailability of pollutants present and past in a Mediterranean port environment heavily contaminated with Cu and OSn
Hou, Bo. „Mechanism of dpH/TAT [DeltapH/TAT]-dependent protein transport at the thylakoid membrane“. [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975658646.
Der volle Inhalt der QuelleArruda, Kátia Magalhães. „A ATUAÇÃO DO JUDICIÁRIO TRABALHISTA E A PRECARIZAÇÃO DO TRABALHO: as decisões do TST e TRT do Maranhão e sua relação com a terceirização e flexibilização do trabalho“. Universidade Federal do Maranhão, 2008. http://tedebc.ufma.br:8080/jspui/handle/tede/817.
Der volle Inhalt der QuelleThe Judicial Power and the precarization of labor. Reflection of judicial decisions in social life has not been approached with the importance the matter requires, especially where the relations resulting from the conflicts between capital and work are concerned. The purpose of this paper is to draw the attention to decisions made by the Labour Federal High Court and the Regional Labour Court in Maranhão relative to precarious labour in Brazil, with emphasis on aspects such as contracting out, flexibilization of rights, poor health and hygienic conditions of workers and degrading work, which, sometimes, reaches the boundaries of slavery. The judicial posture adopted by the Labour Justice seeks to strike a balance between protecting the worker and preserving the company. Considering that the Judicial Power is part of the capitalist State, accomplishing that goal is questionable. In despite of that, the Labour Justice has developed and established itself as the branch of the Judiciary closest to social issues, not only when it plays the role of a mediator between individual and collective conflicts, but also when it, through its judges, prevents the fraud to the employment protection legislation. It can be concluded that the decisions of the Judicial Power based on constitutional principles and rules of employment protection and dignity of human being contribute to the effectiviness of labour rights.
O Judiciário trabalhista e a precarização do trabalho. Estudo sobre a atuação da justiça do trabalho e a relação de suas decisões com a precarização do trabalho no Brasil, considerando que esse é o ramo especializado para dirimir conflitos decorrentes das relações oriundas entre capital e trabalho. A presente pesquisa utiliza a jurisprudência do Tribunal Superior do Trabalho e do Tribunal Regional do Trabalho do Maranhão nos temas de terceirização, flexibilização de direitos, condições de saúde e higiene do trabalhador e formas degradantes de trabalho, inclusive em condição análoga à de escravo. Conclui-se que a postura jurídica adotada pela Justiça do Trabalho oscila entre a proteção ao trabalhador e a preservação da empresa, buscando um ponto de equilíbrio cujo alcance é questionável, uma vez que o Judiciário é poder integrante do Estado capitalista. A Justiça do Trabalho cresceu e se firmou como o ramo do Judiciário mais ligado às questões sociais, ao estabelecer uma prática mediadora nos conflitos individuais e coletivos, e impedir ou reprimir com suas decisões, a fraude à legislação trabalhista. Percebe-se, por fim, que as decisões do Poder Judiciário, exaradas em sentenças ou acórdãos, podem contribuir para a efetividade dos direitos trabalhistas, quanto mais estejam respaldadas nas regras e princípios constitucionais da proteção ao trabalho e da dignidade da pessoa humana.
Tsui-Bowen, Alethea. „Solid phase microextraction of amino-dinitrotoluenes in tissue“. Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4649/.
Der volle Inhalt der QuelleYue, Junqi. „Destruction of TNT and RDX residues and devices /“. View online ; access limited to URI, 2005. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3188852.
Der volle Inhalt der QuelleNominanda, Helinda. „Amorphous silicon thin film transistor as nonvolatile device“. Texas A&M University, 2008. http://hdl.handle.net/1969.1/86004.
Der volle Inhalt der QuellePannier, Andy Joseph. „Reductive transformation of 2,4,6-Trinitrotoluene by Yarrowia lipolytica AN-L15 under conditions of different initial pH of the culture medium or in the presence of ferrihydrite“. Thesis, Montana State University, 2009. http://etd.lib.montana.edu/etd/2009/pannier/PannierA0509.pdf.
Der volle Inhalt der QuelleGlen, N. W. „The co-operative breeding behaviour of the long-tailed tit (Aegithalos caudatus)“. Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233483.
Der volle Inhalt der QuelleTodd, I. A. „An experimental analysis of the foraging behaviour of blue tits (Parus caeruleus L.)“. Thesis, Bucks New University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384744.
Der volle Inhalt der QuelleMcKinney, Ronan. „Picturing 9/11 : trauma, technics, mediation“. Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/47167/.
Der volle Inhalt der QuelleFincher, Jennie. „Decentering and the Theory of Social Development“. Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc149590/.
Der volle Inhalt der QuelleMATTOS, Alessandra Batista de. „Determinação da troponina T cardíaca humana empregando sistema de microbalança de quartzo por injeção de fluxo“. Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/1774.
Der volle Inhalt der QuelleCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
As determinações da troponina cardíaca T (TnT) podem contribuir para o diagnóstico e tratamento de infarto agudo do miocárdio e para a estratificação dos riscos dos pacientes com síndromes coronárias agudas no que respeita ao risco relativo de mortalidade. Neste trabalho, um sistema de microbalança de quartzo por injeção de fluxo baseado na alteração de freqüência elétrica em resposta à ligação antígeno-anticorpo foi empregado para determinação da TnT cardíaca. As variações de freqüências foram registradas por um contador de freqüência acoplado a um microcomputador. O anticorpo monoclonal específico foi imobilizado sobre a superfície de um eletrodo de cristal de quartzo por ligação irreversível via monocamadas auto-organizadas. O adsorbato composto por filme de alcanotiól foi formado incubando uma solução de 2-aminoetanotiol (cisteamina) por 2 h, seguido por glutaraldeído a 2,5% (v/v). Em seguida, anticorpos monoclonais anti- troponina T (anti-TnT) foram covalentemente imobilizados sobre o eletrodo de ouro do cristal de quartzo e foi usada uma solução de glicina (10mM) como agente bloqueante. Com o imunossensor desenvolvido foi possivel medir concentrações de troponina T com limite de detecção de 0,025 ng/mL. A superfície do sensor pode ser regenerada por injeção de uma solução do dodecil-sulfato de sódio 1% (p/v). A determinação da TnT foi realizada em amostras de soros humanos permitindo seu uso nas aplicações clínicas para diagnóstico do IAM
Luca, Mihai Bogdan Burel Gilles. „Apports du chaos et des estimateurs d'états pour la transmission sécurisée de l'information“. [s.l.] : [s.n.], 2006. http://www.univ-brest.fr/lest/tst/publications/pdf/TheseMihaiBogdanLuca.pdf.
Der volle Inhalt der QuelleThèse soutenue en co-tutelle. Bibliogr. p.165-177. Index.
Derive, Marc. „TLT-1 régule l’activation leucocytaire et contrôle la réponse inflammatoire systémique au cours du sepsis“. Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10151.
Der volle Inhalt der QuelleThe Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) plays a crucial role during the onset of sepsis by amplifying the host immune response. The TREM-Like Transcript-1 (TLT-1) belongs to the TREM family, is selectively expressed on activated platelets, and is known to facilitate platelet aggregation through binding to fibrinogen. Here we show that a soluble form of TLT-1 is implicated in the regulation of inflammation during sepsis by dampening leukocytes activation and modulating platelet-neutrophil crosstalk. A 17-aa sequence of the TLT-1 extracellular domain (LR17) is responsible for this activity through competition with the TREM-1 ligand. While early or late LR17 treatment of septic mice improves survival, treml-1-/- animals are highly susceptible to polymicrobial infection. The present findings identify platelet derived sTLT-1 as a potent endogenous regulator of sepsis associated inflammation and open new therapeutic perspectives
Lecigne, David. „Conception et évaluation de nouveaux peptides internalisants“. Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON13501.
Der volle Inhalt der QuelleThe Tat peptide is one of the most used cell penetrating peptides for internalizing various cargo molecules into cells. The chimaeric molecule thus triggers an efficient cellular biological response when compared with the cargo molecule alone. However, following labeling of the Tat peptide with radiolabeled iodine, less than 1% of the external peptide was internalized. Therefore, there is an opportunity to improve the level of CPP internalization. The ultimate step is the crossing through the plasma membrane. This thesis presents an evaluation of the impact of a hydrophobic group incorporated at different positions to Tat peptide, to promote its interaction with the membrane.A chemically modified amino acid comprising a cholesteryl group was developed in this direction. This amino acid can be inserted at any position within the Tat peptide. Different positions within the Tat peptide were cholesterylated and the effect on the internalization rate of Tat CPP was investigated by flow cytometry and by counting following the radiolabeling of peptides with iodine 125.The addition of cholesterol in the central position of the peptide Tat induces internalization efficiency than a factor of 30 while a smaller increase was observed after the addition of hydrophobic group in lateral positions, N-or C-terminus
Avican, Ummehan. „Twin-arginine translocation in Yersinia : the substrates and their role in virulence“. Doctoral thesis, Umeå universitet, Umeå Centre for Microbial Research (UCMR), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128090.
Der volle Inhalt der QuelleSpeidel, Joshua A. „Computational approaches to structure based ligand design : an illustration for P/CAF bromodomain ligands /“. Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1453183061&sid=21&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Der volle Inhalt der QuelleWeitzel, Annegret. „Tension Free Vaginal Tape (TVT)“. Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-76515.
Der volle Inhalt der QuelleImhof-Rudolph, Heike. „Wehrpflicht ade - tut Scheiden weh?“ Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4897/.
Der volle Inhalt der QuelleChoi, Hyun. „TOT: the association strength heuristic“. Texas A&M University, 2005. http://hdl.handle.net/1969.1/2629.
Der volle Inhalt der QuelleUnosson, Erik. „Arrival control of TFT displays“. Thesis, Högskolan i Gävle, Avdelningen för elektronik, matematik och naturvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-11431.
Der volle Inhalt der QuelleTodde, Carlo. „Exploitation asymétrique d'un corridor THT“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/MQ38713.pdf.
Der volle Inhalt der QuelleBasson, Catherina Susanna. „'n Funksionalistiese benadering tot Bybelvertaling“. Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52954.
Der volle Inhalt der QuelleENGLISH ABSTRACT: The functional approach to translation is investigated in the context of Bible translation. For some practising translators, functionalism has application only in the production of instrumental translations, and for them this approach will inevitably lead to the dethroning of the source text. In Bible translation the status of the source text is very important. With the functional equivalence approach this status is disregarded in an effort to produce a Bible translation that can be used as a missionary instrument. Within functionalism, however, a documentaryexoticising translation can retain the status of the source text and can have the skopos to bridge the cultural gap between Biblical times and the modern world by adding cultural information. This was the skopos of a functional translation of the New Testament in German. Examples from this translation, as well as examples from the NAV (1983), were examined qualitatively to see how additional cultural information could assist the target reader in understanding the otherness of the ancient Biblical text. An empirical investigation was done. Text fragments from the NAV (1983), with cultural information added, were presented to people who study the Bible regularly. The response to the additional cultural information was very positive. The focus in the literature study was on the functional approach to translation, also known as skopos theory. This was compared with the functional equivalence approach as well as the newer relevance theory approach as described by Gutt. Attention was also given to the importance of culture in translation. In the functional approach other skopoi and other target groups can be identified. In a further study, the application of this approach to the translation of the Old Testament can be investigated. The functional approach might also be used in the translation of other ancient religious texts such as the Koran and the Torah. The benefits of co-operation between experts in the field of the Biblical languages and culture and practising translators are shown. The skopos of the translation will give such a team the framework within which they can produce a translation with a specific aim for a specific target group. The functional approach can be applied broadly to include both instrumental and documentary translations. In the case of Bible translation the documentary-exoticising translation provides the framework wherein the source text of the Bible can be accounted for in a responsible way. The application of functionalism is, however, wide enough to include all types of translation, provided that a clear skopos is identified and formulated for each translation.
AFRIKAANSE OPSOMMING: In hierdie studie word ondersoek ingestel na die rol wat die funksionalistiese benadering tot vertaling in Bybelvertaling kan speel. Sommige praktiserende vertalers het 'n beperkte siening van funksionalisme en koppel dit uitsluitlik aan 'n instrumentele vertaling en die noodwendige onttroning van die bronteks. In Bybelvertaling is die status van die bronteks een van die belangrikste kwessies. Met die funksioneel-ekwivalente benadering word hierdie status aangetas om 'n Bybelvertaling te kan lewer wat primêr as sendinginstrument gebruik kan word. Die funksionalistiese benadering bied egter die moontlikheid om 'n vertaling daar te stel wat dokumentêr-eksotiserend is, maar ook aan die leser daarvan bykomende kulturele inligting kan gee sodat die kultuurgaping oorbrug kan word. Hierdie spesifieke skopos is reeds toegepas in 'n funksionalistiese vertaling van die Nuwe Testament in Duits. Gedeeltes uit hierdie vertaling, asook uit die NAV (1983), word kwalitatief ondersoek om te sien hoe bykomende kulturele inligting die leser kan help om die andersheid van die antieke Bybelse teks beter te kan verstaan. In 'n empiriese ondersoek is teksgedeeltes uit die NAVen teksgedeeltes met bykomende kulturele inligting aan persone wat gereeld Bybelstudie doen, voorgelê. Hierdie lesers het die vertaling met die bykomende kulturele inligting baie positief ontvang. In die literatuurondersoek word die funksionalistiese benadering tot vertaling, ook genoem die skopos-teorie, breedvoerig bespreek en vergelyk met die funksioneleekwivalensie- benadering en die nuwer relevansie-teorie soos deur Gutt op vertaling van toepassing gemaak. Die verskillende aspekte van kultuur in vertaling kry ook aandag. Die funksionalistiese benadering bied die moontlikheid om ander skopoi en ander teikenlesers te identifiseer. In 'n verdere studie kan die toepassing van hierdie benadering op die vertaling van die Ou Testament ondersoek word. Die funksionalistiese benadering kan ook gebruik word by die vertaling van ander antieke religieuse tekste soos die Koran en die Torah. Die voordele van samewerking tussen kenners van die brontaal en -kultuur en praktiserende vertalers word uitgewys. In so 'n geval sal 'n duidelike skopos aan die kenners die raamwerk verskaf waa~binne 'n vertaling met 'n spesifieke doel en teikengroep aangepak kan word. Die funksionalistiese benadering kan breedweg toegepas word om sowel instrumentele as dokumentêre vertalings in te sluit. In die geval van Bybelvertaling bied die dokumentêreksotiserende vertaling 'n raamwerk waarbinne die bronteks van die Bybel verantwoordbaar in berekening gebring kan word. Die reikwydte van funksionalisme is egter sodanig dat dit enige tipe vertaling kan insluit op voorwaarde dat 'n duidelike skopos vir elke afsonderlike vertaling gedefinieer word.
Kalis, ML. „Omgewingsgesondheid : 'n poging tot fundering“. Thesis, Cape Technikon, 1993. http://hdl.handle.net/20.500.11838/797.
Der volle Inhalt der QuelleMet hierdie studie word daar gepoog om omgewingsgesondheid, soos dit op plaaslike owerheidsvlak in Suid-Afrika manifesteer, te fundeer. In hierdie poging tot fundering van omgewingsgesondheid word daar spesifiek na omgewingsgesondheidsbeamptes se betrokkenheid by omgewingsgesondheidsdienslewering verwys. ampte1ik as Gesondword die benaming deur die benaming omgewingsgesondheidsbeamptes staan tans heidsinspekteurs bekend, daarenteen I Gesondheidsinspekteur , progressief 'Omgewingsgesondheidsbeampte' vervang. Die funksionele werksveld van omgewingsgesondheidsbeamptes bestaan uit omgewingsaangeleenthede (nie-persoonlike gesondheid) en behels aangeleenthede soos drinkwatersuiwering, waterbesoedelingsbeheer, die suiwering van afloopwater, sanitasie, afvalbeheer (vaste, vloeibare en toksiese afval), voedselhigiene, vleishigiene, omgewingsaspekte ten opsigte van aansteeklike siektes, boukunde, behuising, die daarstel van 'n sosiale omgewing, berdryfshigiene, bedryfsveiligheid, stralingsbeheer, omgewingsgeraasbeheer, termiese besoedelingsbeheer en lugbesoedelingsbeheer. Buiten oorerflikheidsfaktore, kan mens like siektes deur middel van 'n effektiewe omgewingsgerigte diens voorkom word. nit is wenslik om te voorkom dat iemand siek word eerder as om 'n siek persoon te genees. nit is verder irrasioneel om 'n persoon wat genees is, weer in dieselfde omgewing terug te plaas wat homjhaar aanvanklik siek gemaak het.
Schilithz, Priscila Ferreira. „Avaliação da exposição de botos-cinza (Sotalia guianensis Van Benédén, 1864) aos compostos orgânicos de estanho através das concentrações hepáticas de estanho total na costa sudeste e sul do Brasil“. Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7089.
Der volle Inhalt der QuelleDurante as últimas décadas, observou-se um aumento da preocupação em relação aos ecossistemas marinhos devido à grande entrada de poluentes, resultando em efeitos deletérios em organismos aquáticos e seres humanos. Dentre as atividades humanas que podem introduzir compostos tóxicos persistentes e bioacumulativos (PBTs Persistent Bioaccumulative Toxicants) no ambiente marinho está o uso de tintas antiincrustrantes, aplicadas nos cascos de navios para evitar que algas, mexilhões e outros organismos se fixem às embarcações. Não raramente, compostos organoestânicos (OTs) como o Tributilestanho (TBT) ou o Trifenilestanho (TPT) constituíam o princípio ativo de tal preparado. Devido à alta toxicidade desses compostos, a IMO (Organização Marítima Internacional) baniu totalmente o uso dos mesmos. Como os OTs são prontamente bioacumulados, elevadas concentrações de estanho total (SnT) vêm sendo encontradas em cetáceos (Mammalia, Cetacea). Os botos-cinza (Sotalia guianensis Van Beneden, 1864) ocupam elevados níveis tróficos e bioacumulam os PBTs aos quais estão expostos. Alguns autores relataram que o estanho hepático em cetáceos se encontra predominantemente na forma orgânica, visto que, na forma inorgânica tal metal é pobremente absorvido pela mucosa gastrintestinal, de forma que as concentrações hepáticas de SnT refletem o input antrópico de OTs. O presente estudo teve como principal objetivo, avaliar a exposição de botos-cinza aos OTs, através determinação das concentrações hepáticas de estanho total (SnT = orgânico + inorgânico), por Espectrometria de Absorção Atômica com Atomização em Forno de Grafite (GFAAS Graphite Furnace Atomic Absorption Spectrometry). Para tal, amostras de botos-cinza de diferentes áreas do litoral brasileiro, compreendendo a Região da Grande Vitória (GV), Baía de Guanabara (BG), Baía de Sepetiba (B.Sep), a Baía de Paranaguá (PR) e a Baía da Babitonga (SC), foram analisadas, visando comparar ambientes distintamente contaminados com OTs. Sendo assim, as concentrações hepáticas de SnT (em ng/g, peso seco) de botos-cinza variaram de <312 (limite de detecção) a 8.250, para a GV (n=22); de <312 a 14.100, para B.Sep (n = 38); <312 a 5.147, para PR (n= 22), bem como de 626 a 24.780 (ng/g, peso seco) para os botos de SC (n=10). As maiores concentrações foram verificadas nos botos da BG (n=11), variando de 1.265 a 24.882 (ng/g, peso seco). As concentrações encontradas na Baía de Guanabara (BG) estão entre as mais elevadas detectadas em cetáceos.
During the last decades, the large pollutant input has led to an increased concern over marine ecosystems. This environmental contamination results in deleterious effects on aquatic organisms and humans. Among the anthropogenic activities that may introduce persistent bioaccumulative toxicants (PBTs) into the marine environment is the use of antifouling paint. It is applied on ship hulls and other floating structures to prevent algae, mussels and other organisms to fix on these surfaces. Often, organotin compounds (OTs), such as Tributyltin (TBT) or Triphenyltin (TPT), constituted the active ingredient in these mixtures. Due to the high toxicity of these compounds, the IMO (International Maritime Organization), banned their use entirely. As OTs are readily bioaccumulated, high total tin (SnT) concentrations have been found in cetaceans (Mammalia, Cetacea). Guiana dolphins (Sotalia guianensis, Van Beneden, 1864) occupy high trophic levels and bioaccumulate the PBTs they are exposed to. Some authors reported that hepatic tin is predominantly found in its organic form in cetaceans, as inorganic tin is poorly absorbed by gastrointestinal mucosa. Therefore, the hepatic SnT concentration reflect the input of anthropogenic OTs. The present study aimed to evaluate Guiana dolphin exposure to OTs in Brazilian waters through hepatic total tin (SnT = organic + inorganic) concentrations. Analyses were performed by Graphite Furnace Atomic Absorption Spectrometry (GFAAS). Guiana dolphin samples from diferente areas of the Brazilian litoral, comprising the Region of Grande Vitória (GV), Guanabara Bay (BG), Sepetiba Bay (B.Sep), Paranaguá Bay (PR) and Babitonga Bay (SC), have been analyzed for comparison of distinctly OT-contaminated environments. Hepatic SnT concentrations (ng/g dry weight) of Guiana dolphins varied from <312 (detection limit) to 8250, for GV (n = 22); from <312 to 14100, for B.Sep (n = 38); <312 to 5147 for PR (n = 22); as well as from 626 to 24780, for SC (n=10). The highest concentrations were found in dolphins from BG (n = 11), which ranged from 1265 to 24882. The concentrations found in Guanabara Bay (BG) are among the highest detected in cetaceans.
Guillon, Christophe. „Rôle du gène de régulation tat dans la détermination du phénotype biologique des variants SI/lymphotropes et NSI/monocytotropes du VIH-1“. Lyon 1, 1997. http://www.theses.fr/1997LYO1T241.
Der volle Inhalt der Quelle