Auswahl der wissenschaftlichen Literatur zum Thema „Synthèse guidée“
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Zeitschriftenartikel zum Thema "Synthèse guidée"
Colas, Maxime, und Michel Deloizy. „Le Model Based Design pour l’apprentissage par conception guidée“. J3eA 22 (2023): 1009. http://dx.doi.org/10.1051/j3ea/20231009.
Der volle Inhalt der QuelleLandry, Rodrigue, und Omer Robichaud. „Un modèle heuristique pour l’individualisation de l’enseignement“. Revue des sciences de l'éducation 11, Nr. 2 (30.11.2009): 295–317. http://dx.doi.org/10.7202/900496ar.
Der volle Inhalt der QuellePAVAGEAU, S., A.-S. BREDILLET, A. LOPEZ und M. GLONDUS-LASSIS. „La tolérance à l’incertitude lors d’une prise de décision est une compétence complexe du médecin généraliste“. EXERCER 34, Nr. 195 (01.09.2023): 312–21. http://dx.doi.org/10.56746/exercer.2023.195.312.
Der volle Inhalt der QuelleBouchafa, Samia. „Décision cumulative pour la vision dynamique des systèmes“. Revue Française de Photogrammétrie et de Télédétection, Nr. 202 (16.04.2014): 2–26. http://dx.doi.org/10.52638/rfpt.2013.48.
Der volle Inhalt der QuelleChow, Jeng-Yeong, Bo-Xue Tian, Gurusankar Ramamoorthy, Brandan S. Hillerich, Ronald D. Seidel, Steven C. Almo, Matthew P. Jacobson und C. Dale Poulter. „Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus“. Proceedings of the National Academy of Sciences 112, Nr. 18 (21.04.2015): 5661–66. http://dx.doi.org/10.1073/pnas.1505127112.
Der volle Inhalt der QuelleArechaga, Ignacio, und Phil C. Jones. „Quick guide: ATP synthase“. Current Biology 11, Nr. 4 (Februar 2001): R117. http://dx.doi.org/10.1016/s0960-9822(01)00055-0.
Der volle Inhalt der QuelleBodel, Catherine, Philippe Delarue und Robert Bausière. „Architectures multiniveaux : synthèse d'un guide de choix“. Revue internationale de génie électrique 6, Nr. 1-2 (30.04.2003): 121–42. http://dx.doi.org/10.3166/rige.6.121-142.
Der volle Inhalt der QuelleBodel, Catherine, Philippe Delarue und Robert Bausière. „Architectures multiniveaux : synthèse d'un guide de choix“. Revue internationale de génie électrique 6, Nr. 3-4 (30.08.2003): 351–56. http://dx.doi.org/10.3166/rige.6.351-356.
Der volle Inhalt der QuelleKer, De-Sheng, Sze Lei Pang, Noor Farhan Othman, Sekar Kumaran, Ee Fun Tan, Thiba Krishnan, Kok Gan Chan, Roohaida Othman, Maizom Hassan und Chyan Leong Ng. „Purification and biochemical characterization of recombinant Persicaria minor β-sesquiphellandrene synthase“. PeerJ 5 (28.02.2017): e2961. http://dx.doi.org/10.7717/peerj.2961.
Der volle Inhalt der QuelleMaceluch, J., M. Kmieciak, Z. Szweykowska-Kulińska und A. Jarmołowski. „Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p.“ Acta Biochimica Polonica 48, Nr. 3 (30.09.2001): 699–709. http://dx.doi.org/10.18388/abp.2001_3904.
Der volle Inhalt der QuelleDissertationen zum Thema "Synthèse guidée"
Laurent, Gautier. „Synthèse de nanoparticules multifonctionnelles pour la radiothérapie guidée par imagerie“. Thesis, Besançon, 2014. http://www.theses.fr/2014BESA2025/document.
Der volle Inhalt der QuelleThe original properties of nanoparticles make them extremely attractive in the field of oncology. In fast, gold nanoparticles coated by macrocyclic ligands allow imaging and therapy with only one object. Therefore, multifunctional platforms are very promising for image-guided therapy, winch constitutes an important step towards personalization of treatment. This consists of stimulating the therapeutic activity of the nanoparticles when their accumulation is high within the tumor zone and low in healthy tissues. A higher selectivity of the treatment is therefore expected. Biodistribution study by SPECT/CT has shown free circulation, renal elimination and a moderate retention by the liver of the nanoparticles. However, this retention is not due to the opsonisation processus. The MRI study of rats' brain carrying a gliosarcoma has shown an accumulation of nanoparticles Au@FADOTAGA-Gd in the tumor. Moreover, the co-labeling of these nanoparticles by Ge and 64Cts2+was successfully performed. As a result, PET/MRI images, a much researched combination but rarely achieved, were acquired on the same animal alter intravenous injection of the co-labeled nanoparticles. The radiosensitizing character of nanoparticles Au@TADOTAGA was confirmed by the follow up of tumor growth alter a treatment by MRT (microbeam irradiation) 15 minutes after intratumoral injection of nanoparticles. The therapeutic gain of this treatment has been validated by MRT 24 hours after intravenous injection of nanoparticles to rats carrying gliosarcoma (radioresistant tumor in radiosensitive organ)
Alric, Christophe. „Synthèse et caractérisation de nanoparticules d'or multifonctionnelles pour la radiothérapie guidée par imagerie“. Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10175.
Der volle Inhalt der QuelleRadiation therapy is nowadays one of the most common treatments in the fight against cancer, in spite of its lack of selectivity in tissue destruction. A better selectivity is expected to be achieved when radiosensitizing nanoparticles are used for enhancing the dose effects of the ionizing radiations. The aim of this PhD work is to synthesize and to characterize multifunctional gold nanoparticles (Au@DTDTPA), detectable in vivo through various techniques such as by X-ray imaging, MRI and y-ray scintigraphy, as well as evaluating their capability to be used as image-guided radiosensitizing agents to treat tumors. The biodistribution of the Au@DTDTPA nanoparticles in healthy rats is monitored by X-ray imaging, MRI and y-imaging and shows that they freely circulate in the blood flow without being detected by the immune system and that they are excreted by the urine through renal filtration. In the case of cerebral tumor bearing rats, the gold nanoparticles accumulate temporarily in the tumoral zone before being eliminated by urine. The radiosensitizing behavior of the Au@DTDTPA nanoparticles was demonstrated in vitro using the comet assay, by quantifying the increase of DNA strand breaks caused to nanoparticle-labeled U87 human glioblastoma cells, compared to the unlabeled cells. The capability of these nanoparticles to increase the effects of ionizing radiations was then shown in vivo with rats bearing aggressive bone tumors (osteosarcoma). When an intratumoral injection of Au@DTDTPA nanoparticles was performed before the tumor irradiation, the rats' median survival time was prolonged and the tumor reappearance was differed, compared to the control groups. The MRI monitoring of the accumulation of the Au@DTDTPA nanoparticles on the tumoral site of gliosarcome 9L bearing rats after intravenous injection permitted the irradiation by X-ray microbeams when the nanoparticles distribution was favorable. The median survival time of nanoparticle treated rats was indeed extended compared to the control groups. This work therefore showed the possibility to use Au@DTDTPA nanoparticles combining imagery and therapy features as image-guided radiosensitizing agents to treat tumors. The increase of the retention time of Au@DTDTPA nanoparticles within the tumor site could prolong threated rats’ lifespan
Courty, Nicolas. „Contributions aux schémas d'Analyse/Synthèse en Animation par ordinateur“. Habilitation à diriger des recherches, Université de Bretagne Sud, 2013. http://tel.archives-ouvertes.fr/tel-00861836.
Der volle Inhalt der QuelleAl-Hakawati, al-Dakkak Oumayma. „Extraction automatique de paramètres formantiques guidée par le contexte et élaboration de règles de synthèse“. Grenoble INPG, 1988. http://www.theses.fr/1988INPG0056.
Der volle Inhalt der QuelleSagne, Jérôme. „Etude expérimentale d'antennes synthétiques utilisant des fibres en silice : Stabilisation d'un réseau d'antennes en réception : Contrôle interférométrique du pointé d'un système en émission“. Limoges, 2004. http://aurore.unilim.fr/theses/nxfile/default/d2884e2c-adb0-4070-884f-70a0990acc8b/blobholder:0/2004LIMO0040.pdf.
Der volle Inhalt der QuelleThe use of synthesize aperture setup offers undeniable advantages moreover for realizing high angular resolution receiving as for transmitting setup. In this kind of instrument, the optical path on the different interferometric arms of the array must be controlled with high accuracy in order to allow the setup to work in coherent mode. This manuscript presents the laboratory implementation of two synthesize aperture setup which the goal is to be used; as a receiver for the first and as a transmitter for the second. The first study has consisting in implementing an external metrology setup of a synthesize antenna destined to observed stellar objects. This project takes place within the framework of a spatial instrument using fibred technique available in our laboratory. This study is particularly focused on the control of the path difference between the source and the telescope focus. This function is achieved among other by the servo control of the position of the different aperture of the setup in the wave plane of the observed object by using an interferometric method. The experimental setup composed of two apertures spaced of two meters allows obtaining interference fringes with contrasts varying between 85% and 92 %. The principle of positioning of the apertures in the wave plane of the scientific source has been validated in this study. The second study has consisting in realizing a transmitting synthesize antenna composed of a lenses array fed by optical fibre. In a first time, a two lenses array has been experimentally implemented and has shown the possibility to realize the pointing of the antenna with several steps in a range of 138 μ rad. In a second time, an error signal destined to servo control the optical path difference between the two arms of the antenna has been obtained. The results on the error signal shows that the optical path residual fluctuation will stay lower than λ/32 in the case of open loop. This fluctuation stays lower than λ/24 error from which we can notice a notable deterioration of the diffraction pattern of the antenna
Barberot, Chantal. „Vers un nouvel outil d'étude de la reconnaissance hôte-ligand : conception de nouveaux inhibiteurs de PDE4 guidée par docking quantique, synthèse et évaluation biologique“. Thesis, Reims, 2013. http://www.theses.fr/2013REIMS013/document.
Der volle Inhalt der QuelleFor the research of new treatment of bronchopulmonary diseases such as asthma and chronic obstructive pulmonary disease (COPD), the PDE4 inhibitors are an attractive target. Our laboratory is interested in a new PDE4 inhibitors family based on the pyridazinone pattern. For this purpose, this thesis couples molecular modeling (docking: methodological development and application), organic synthesis and biological tests.First, the development of the molecular docking software AlgoGen was continued. AlgoGen (initially created at university of Lorraine in 2009) is a program which couples a genetic algorithm for the conformational research and a protein-ligand energy evaluation at the quantum semi-empirical level while other software do this evaluation at a classical level. Quantum energy calculations are very time consuming. That is the reason why some modifications have been made to improve its efficiency for the conformational search. This software was then used for calculations on a set of 22 dimers (typical in biological molecular recognition) as well on 8 ligand-protein complexes.Secondly, eight inhibitors were synthesized and tested in vitro on the PDE4 target. To complete the experimental part, a structure-activity relationship study was carried out through a molecular docking to rationalize the measured activity (IC50). Finally, pharmaco-modulations guided by docking were made to propose new inhibitors with more affinity with the protein
Garlatti, Laura. „Development of Bunyavirales endonucleases inhibitors by in situ click chemistry“. Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0586.
Der volle Inhalt der QuelleWith a worldwide repartition and limited therapeutic options Bunyavirales viruses represent a major public health issue. The replication machinery of these viruses is governed by the intricate L-protein that displays an endonuclease activity responsible for the cap-snatching mechanism that allows viral transcription. This key enzyme was identified as a promising target to develop antivirals. Its catalytic mechanism of RNA hydrolysis mediated by Mg2+ ions enables the development of diketo acid (DKA) metal-chelating inhibitors. Target-Guided-Synthesis (TGS) is a powerful method that directly involves the therapeutic target that assembles its own inhibitors in its active site like LEGOs®. Herein, we describe the use of Bunyavirales endonucleases as reaction vessels for the In Situ generation of metal-chelating inhibitors. A library of 25 N-triazolyl-DKA (NT-DKA), C-triazolyl-DKA (CT-DKA) and C-triazolyl-DHP (CT-DHP) compounds was generated with new and original synthesis pathways via click chemistry. The compounds were biophysically characterized by Microscale Thermophoresis (MST) and Differential Scanning Fluorimetry (DSF) and their inhibitory potency was evaluated in vitro and in infected cells culture. Moreover, a fluorescein-DKA ligand was synthesized for the development of a competition Fluorescence Polarization (FP) assay to determine the activity of the compounds. High-affinity ligands that demonstrated a potent efficiency in vitro and in cellula were identified. In the context of the COVID-19 pandemic, the compounds library was repositioned against SARS-CoV-2 exonuclease which opened new possibilities for the development of metal-chelating Coronavirus inhibitors
Obszynski, Julie. „Conception et synthèse d'aminoglycosides guidées par l'ARN“. Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF018.
Der volle Inhalt der QuelleThe development of new antibiotics is a major public health issue. Given the high potential of aminoglycosides as antibiotics, these compounds have aroused great interest in many research groups. However, despite their maturity, their use is still limited because of their toxicity and the increasing development of resistance mechanisms to aminoglycosides. To better understand the problems inherent to their use, it is crucial to understand their action a cellular level, and to study the interactions with their molecular targets (RNA and protein). In addition to their antibiotic power, aminoglycosides are also universal ligands for several RNAs, capable of specific interactions with RNAs of HIV-1: DIS, TAR and RRE. The elaboration of modified aminoglycosides presents a huge advantage because the domain of application, and therefore the benefits, are important. Nevertheless, the structural complexity of these molecules is a major constraint, chemoselective functionalization is essential but unfortunately poorly described in the literature.In this work, we developed two approaches to target the DIS and/or the A site of the bacterialribosome. The first one, unique but challenging is based on the concept of in situ click chemistry. The second approach is conventional and is based on the selective functionalization of some keypositions of aminoglycosides
Darzacq, Xavier. „Etude des petits ARN guides de méthylation en 2 -O-ribose et guides de pseudouridylation : Biogénèse, fonction et organisation nucléaire des petits ARN guides“. Toulouse 3, 2002. http://www.theses.fr/2002TOU30042.
Der volle Inhalt der QuelleKhlifi, Soumaya. „Nanomatériaux hybrides luminescents à clusters de métaux de transition : synthèse, mise en forme et modulation des propriétés optiques“. Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1S091.
Der volle Inhalt der QuellePhotoluminescent materials are playing a major role in applications related to photonics, optoelectronics or lighting. Combining them with polymers allows the design of easy-to-shape-functional materials with enhanced application versatility. Related to this, hybrid materials composed of an organic polymer matrix containing strongly luminescent octahedral metal clusters were prepared. Octahedral metal clusters have several advantages: a deep luminescence in the red and the near-IR region, a high quantum yield, a large Stokes shift and no photobleaching or photoblinking effects. As organic host matrices, PMMA and PDMS were used because of their optical and mechanical properties in addition to their thermal stability. However, a prerequisite for realizing hybrid materials is to homogeneously introduce the ceramic inorganic emitter in the organic polymer to avoid segregation-phase phenomena. For this purpose, several integration approaches were developed to prepare new hybrid materials. Meanwhile, spectroscopic analysis were performed on these hybrids demonstrating their huge potential. Actually, these hybrids were used to design a self-erasable inkless light-imprinting material when the hybrid is combined with an organic fluorophore, and 1D- and 2D-waveguides. The 1D-waveguides can be applied for integrated photonics while 2D-waveguides combined with liquid-crystals lead to a new luminescent PDLC (Polymer Dispersed Liquid Crystal) material for Luminescent Solar Concentrator technology
Bücher zum Thema "Synthèse guidée"
Les écrits de synthèse: Des outils méthodologiques pour rédiger comptes rendus, rapports, notes de synthèse. Paris: Bertrand-Lacoste, 2007.
Den vollen Inhalt der Quelle findenProgramme d'appui à la consolidation du processus de décentralisation en Guinée. Comité de pilotage. Synthèse des chantiers en cours et perspectives pour 2012. Conakry?]: Ministère de l'administration du territoire et de la décentralisation, 2012.
Den vollen Inhalt der Quelle findenLabelle, Réal. Cas de comptabilité: Méthode et modèles d'analyse et de synthèse. 3. Aufl. Montréal, Qué: Éditions Sciences et culture, 1995.
Den vollen Inhalt der Quelle findenU, Schubert, Hüsing Nicola und Laine Richard M. 1947-, Hrsg. Materials syntheses: A practical guide. Wien: Springer, 2008.
Den vollen Inhalt der Quelle finden(Guinea), Centre de recherche agronomique de Bordo. Amélioration varietale de l'arachide en Basse Guinée et en Haute Guinée: Synthèse des travaux. [Guinea]: Ministère de l'agriculture, des eaux et forêts, Institut de recherche agronomique de Guinée, Centre de recherche agronomique de Bordo, Kankan, 2002.
Den vollen Inhalt der Quelle findenAmphetamine syntheses: Overview & reference guide for professionals. Spring Hill, Fl: Thoth Press, 1998.
Den vollen Inhalt der Quelle finden1959-, Regalbuto John R., Hrsg. Handbook of catalyst preparation. Boca Raton: Taylor & Francis, 2007.
Den vollen Inhalt der Quelle findenRoy, Louise. Journal de bord: Orthographe et synthaxe - guide et corrige. Montréal, Qué: Centre Educatif et Culturel Inc, 1988.
Den vollen Inhalt der Quelle finden(Irishi), Namboothiri I., Hrsg. Organic syntheses based on name reactions: A practical guide to 750 transformations. 3. Aufl. Amsterdam: Elsevier, 2012.
Den vollen Inhalt der Quelle findenA, Flowers Robert, Skrydstrup Troels und Royal Society of Chemistry (Great Britain), Hrsg. Organic synthesis using samarium diiodide: A practical guide. Cambridge: Royal Society of Chemistry, 2010.
Den vollen Inhalt der Quelle findenBuchteile zum Thema "Synthèse guidée"
Gueguen, Marie. „A Crack in the Track of the Hubble Constant“. In Synthese Library, 33–55. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-26618-8_3.
Der volle Inhalt der QuelleMathie, Alex. „Black Holes and Analogy“. In Synthese Library, 249–76. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-26618-8_14.
Der volle Inhalt der QuelleDekkers, Rob, Lindsey Carey und Peter Langhorne. „Combining Quantitative and Qualitative Syntheses“. In Making Literature Reviews Work: A Multidisciplinary Guide to Systematic Approaches, 417–37. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-90025-0_12.
Der volle Inhalt der QuelleWonglakhon, Tanakorn, und Dirk Zahn. „Molecular Simulations as Guides to Ammonothermal Syntheses of Nitrides—State of the Art and Perspectives“. In Ammonothermal Synthesis and Crystal Growth of Nitrides, 275–86. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-56305-9_15.
Der volle Inhalt der QuelleLi, Peng, und Guoyao Wu. „Characteristics of Nutrition and Metabolism in Dogs and Cats“. In Nutrition and Metabolism of Dogs and Cats, 55–98. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-54192-6_4.
Der volle Inhalt der Quelle„Synthèse“. In Transparence et responsabilité : Guide pour l'État actionnaire, 123–41. OECD, 2010. http://dx.doi.org/10.1787/9789264056664-8-fr.
Der volle Inhalt der Quelle„Anticortisoliques de synthèse“. In Méga Guide STAGES IFSI, 562. Elsevier, 2015. http://dx.doi.org/10.1016/b978-2-294-74529-4.00187-7.
Der volle Inhalt der Quelle„Macroprogestatifs de synthèse“. In Méga Guide STAGES IFSI, 785. Elsevier, 2015. http://dx.doi.org/10.1016/b978-2-294-74529-4.00247-0.
Der volle Inhalt der Quelle„Antipaludéens de synthèse“. In Méga Guide STAGES IFSI, 1769. Elsevier, 2015. http://dx.doi.org/10.1016/b978-2-294-74529-4.00576-0.
Der volle Inhalt der Quelle„En guise de synthèse“. In Claude Castonguay, 89–104. Presses de l'Université du Québec, 2011. http://dx.doi.org/10.2307/j.ctv18pgrp4.11.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Synthèse guidée"
Abdul rabu, Siti nazleen, und Najwa amirah Harun. „TRENDS, FACTORS, AND CONDITIONS POTENTIALLY INFLUENCING ONLINE DISCUSSION FORUM OUTCOMES: A SYNTHESIZED FROM SYSTEMATIC REVIEW“. In eLSE 2018. Carol I National Defence University Publishing House, 2018. http://dx.doi.org/10.12753/2066-026x-18-121.
Der volle Inhalt der QuelleBerichte der Organisationen zum Thema "Synthèse guidée"
Roth, Emmanuelle. Considérations clés : Flambée épidémique de virus Ébola en Guinée en 2021, le contexte de N’Zérékoré Synthèse. SSHAP, März 2021. http://dx.doi.org/10.19088/sshap.2021.018.
Der volle Inhalt der QuelleNelson, Gena, Angela Crawford und Jessica Hunt. A Systematic Review of Research Syntheses for Students with Mathematics Learning Disabilities and Difficulties. Boise State University, Albertsons Library, Januar 2022. http://dx.doi.org/10.18122/sped.143.boisestate.
Der volle Inhalt der QuelleGrzybowski, Bartosz A. Engines of discovery: Computers in advanced synthesis planning and identification of drug candidates. AsiaChem Magazine, November 2020. http://dx.doi.org/10.51167/acm00010.
Der volle Inhalt der QuelleDudley, J. P., und S. V. Samsonov. Système de traitement automatisé du gouvernement canadien pour la détection des variations et l'analyse des déformations du sol à partir des données de radar à synthèse d'ouverture de RADARSAT-2 et de la mission de la Constellation RADARSAT : description et guide de l'utilisateur. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/329134.
Der volle Inhalt der QuelleHuntington, Dale. Advances and challenges in postabortion care operations research: Summary report of a global meeting. Population Council, 1998. http://dx.doi.org/10.31899/rh1998.1005.
Der volle Inhalt der QuelleRoldan de Jong, Tamara. Rapid Review: Perceptions of COVID-19 Vaccines in South Africa. SSHAP, April 2022. http://dx.doi.org/10.19088/sshap.2021.021.
Der volle Inhalt der QuelleJoly, Kyle, und Matthew Cameron. Caribou vital sign annual report for the Arctic Network Inventory and Monitoring Program: September 2022?August 2023. National Park Service, 2023. http://dx.doi.org/10.36967/2301773.
Der volle Inhalt der QuelleSmit, Amelia, Kate Dunlop, Nehal Singh, Diona Damian, Kylie Vuong und Anne Cust. Primary prevention of skin cancer in primary care settings. The Sax Institute, August 2022. http://dx.doi.org/10.57022/qpsm1481.
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