Auswahl der wissenschaftlichen Literatur zum Thema „Swerim AB“

Salah satu atribut dari pelayanan jasa transportasi umum adalah ticketing system, dimana saat ini sistem tersebut belum terintegrasi dan masih memerlukan peningkatan layanan. Oleh karena itu, pengembangan ticketing system menjadi integrated ticketing system sangat diperlukan untuk menjadikan transportasi umum yang kompetitif dan memiliki daya tarik bagi pengguna jasa transportasi. Dalam melakukan analisis terkait dengan pengembangan sistem tiket baru yang terintegrasi, penyusunan penelitian ini menggunakan pendekatan penelitian kualitatif dan data yang bersumber dari dokumentasi, archival records, interview, direct, dan participant observations. Selain itu, penyusunan penelitian ini juga menggunakan kasus dari Värmlandstrafik AB sebagai comparative study dan teori New Services Development sebagai pendekatan untuk memberikan penilaian tentang kemungkinan dalam menerapkan integrated ticketing system. Dengan menganalisa data hasil survai pengguna jasa transportasi, penelitian ini memberikan description dan explanation tentang karakteristik dan travel behaviour pengguna jasa transportasi, serta penilaian terhadap layanan ticketing system yang mendasari perlunya pengembangan layanan menjadi integrated ticketing system. Kemudian, dengan menggunakan comparative study akan memberikan hasil analisis terkait dengan hal-hal yang diperlukan dalam mengembangkan integrated ticketing system berdasarkan pada organizational process.

Kereta api sebagai moda angkutan massal memiliki karakteristik yang unik. Angkutan ini memiliki kapasitas besar, tingkat keamanan yang tinggi, dan bebas dari kemacetan lalu lintas. Karakteristik tersebut membuat kereta api sebagai angkutan umum utama. Meskipun transportasi kereta api memiliki banyak manfaat bagi kehidupan masyarakat tetapi mereka masih dihadapi oleh masalah. Saat ini operasional kereta api masih diwarnai dengan keterlambatan, kondisi kereta yang tidak baik, dan informasi perjalanan kereta api tidak jelas yang sering merugikan penumpang, dan banyak layanan yang ditawarkan gagal untuk menarik penumpang. Kondisi ini mengakibatkan penurunan kualitas pelayanan dan pengoperasian kerta api tidak memadai. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara kepuasan konsumen terhadap layanan yang disediakan dengan keinginan untuk melakukan keluhan dan untuk mencari faktor dari kualitas layanan yang memiliki pengaruh yang signifikan antara kepuasan pelanggan terhadap pelayanan PT KAI. Dari data, dan juga studi perbandingan antara PT Kereta Api Indonesia dan Statens Järnvägar AB, Swedia, dapat direkomendasikan desain sistem penanganan pengaduan yang perlu disesuaikan dengan kepentingan konsumen. Penelitian ini menghasilkan beberapa temuan. Pertama, ada enam faktor atribut kualitas layanan yang memiliki pengaruh yang signifikan terhadap kepuasan pelanggan terhadap pelayanan PT KAI untuk kelas komuter (Information, Appearances, Service coverage, Tangible, Safety & security, and Cost). Untuk kelas bisnis memiliki tujuh faktor, (Travel time, Information, Scheduling, Comfort, Tangible, Safety & security, and Service coverage). Dan untuk kelas eksekutif, juga memiliki tujuh faktor yang mempunyai pengaruh signifikan terhadap kepuasan pelanggan, (Appearances, Safety & security, Information, Comfort, Tangible, Travel time, and Cost). Untuk hasil penelitian kedua menunjukkan bahwa untuk kelas komuter atribut Safety & security dan untuk kelas bisnis atribut Information adalah atribut yang memiliki pengaruh signifikan pada keinginan untuk melakukan keluhan. Sementara untuk kelas eksekutif, sebagian besar penumpang puas dengan pelayanan yang diberikan oleh PT. KAI. Untuk pertanyaan penelitian ketiga, untuk mengurangi jumlah keluhan, maka harus mengambil beberapa mekanisme yang efektif untuk menangani pengaduan tersebut belajar dari sistem yang diterapkan oleh SJ. AB.Kata kunci: Pelayanan keluhan penumpang, PT Kereta Api Indonesia, Statens Järnvägar ABRead phonetically

BackgroundResponses to anti-PD-1 antibodies (aPD1) have changed the therapeutic landscape of metastatic melanoma, however predictive biomarkers of resistance are lacking. Beta-catenin pathway activation has been inversely correlated with tumor-infiltrating T lymphocytes in melanoma as well as several other solid tumors.1 However, activating mutations involving this pathway are rare, implying that the modulation of upstream Wnt ligand/Fzd receptor (Wnt/Fzd) signaling could be a critical regulator of anti-tumor immunity. Indeed, expression of certain Wnt ligands has been associated with inferior responses to checkpoint inhibitor immunotherapy in metastatic melanoma patients.2 In addition, we have further found tumor-derived paracrine and autocrine Wnt ligand signaling to drive dendritic cell tolerization and to be associated with escape from aPD1 therapy in transgenic mouse models.3 4 No studies to date have focused on the impact of the various regulators and components of proximal Wnt/Fzd receptor signaling on resistance to aPD1 therapy in melanoma patients. We therefore developed a unique Wnt/Fzd pathway panel using Nanostring technology to examine alterations in Wnt ligands, their receptors, and regulators as a predictor of aPD1 resistance.MethodsTo test whether this panel could identify aPD1 resistant patients, Nanostring analysis was performed on archival FFPE tissue specimens of 12 responding (R) and 12 nonresponding (NR) metastatic melanoma patients (pts) taken prior to aPD1 monotherapy. Response was assessed radiographically by week 12 RECIST criteria.ResultsSeveral components of both canonical and non-canonical Wnt ligand signaling, including regulators of autocrine/paracrine signaling, were upregulated in aPD1 NR pts compared to R pts (figure 1, table 1). GZMB, CD8, and IFNG were among cytotoxic T cell related genes upregulated in Rs. Upregulation of SFRP2 and DKK2 in NR pts, classically negative feedback regulators of Wnt ligands, are a reflection of enhanced Wnt ligand signaling activity.Abstract 425 Table 1Most significantly upregulated Wnt ligands, receptors, and pathway components in patients that do not respond to aPD1Abstract 425 Figure 1Volcano plot of the top 30 genes from the nanostring panel comparing responders (red) and nonresponders (blue)ConclusionsThis study supports the importance of paracrine and autocrine Wnt ligand signaling in the regulation of effector T cell responses and aPD1 resistance in cancer. In addition to predicting response to aPD1 checkpoint inhibitor immunotherapy, these findings further suggest that this Wnt signaling panel could serve as a predictive marker of immunologic response to Wnt ligand inhibitors, such as the PORCN inhibitors, which are currently under development. We continue to accrue additional pts to further validate these findings. Future studies will include a comparison of pre-treatment and on-treatment biopsies to evaluate these markers as predictors of adaptive aPD1 resistance.AcknowledgementsHolly Dressman, PhD of the Duke Center for Genomic and Computational Biology for her assistance with the Nanostring samples; Jenna Goodwin, Carol Ann Wiggs, and Jennifer Nixon of the Duke Clinical Melanoma Research Team for their assistance with the melanoma tissue acquisition protocol; Tadas Rimkus of Nanostring for his assistance with analysisTrial RegistrationNCT02694965Ethics ApprovalThis study was approved by Duke University’s Institutional Review Board, protocol number Pro00059349ConsentNot applicableReferencesLuke JJ, B.R., Spranger S, Sweis RF, Lingen MW, Lengyel E, Zha Y, Gajewski TF. Wnt/Beta-catenin pathway activation correlates with immune exclusion across most human cancers. Journal of Clinical Oncology 2016;34(15).Hugo W, et al. Genomic and transcriptomic features of response to anti-pd-1 therapy in metastatic melanoma. Cell 2016;165(1): p. 35–44.DeVito NC, X.C., Zhao F, Evans KS, Theivanthiran B, Lewicki J, Hoey T, Hurwitz H, Strickler JH, Hanks BA. Paracrine wnt-β-catenin signaling inhibition as a strategy to enhance the efficacy of anti-PD-1 antibody (Ab) therapy in a transgenic model of melanoma. Journal of Clinical Oncology, 2017. 35(no. 15_suppl).Zhao F, et al. Paracrine Wnt5a-beta-Catenin signaling triggers a metabolic program that drives dendritic cell tolerization. Immunity 2018;48(1): p. 147–160 e7.

Os traumatismos dentários são frequentes na rotina clínica dos Cirurgiões-Dentistas e a correta conduta do tratamento é fundamental para um bom prognóstico. Objetivo: O objetivo deste trabalho foi avaliar o perfil e a conduta dos cirurgiões-dentistas das 41 Unidades Básicas de Saúde do município de Patos-PB frente aos traumatismos dentários. Metodologia: Para coleta de dados foi aplicado um questionário contendo perguntas sobre o perfil demográfico dos profissionais e a experiência com traumatismo dental. Os dados foram analisados estatisticamente pelo Qui-quadrado, com margem de erro de 5%. Resultados: 66,7% dos Cirurgiões-dentistas eram do sexo feminino, 83,3% fizeram a graduação em instituição de ensino pública, 33,3% possuíam mais de 10 anos de formados, 53,3% eram especialistas, apenas 10% relataram ter algum tipo de cursos na área e a especialidade predominante foi a de Saúde da Família (16,7%). Sobre a prevalência do trauma dental na rotina de atendimentos, 46,7% dos entrevistados relataram ter recebido pacientes com traumatismo dentário, destes, 36,7% receberam apenas casos de fratura dental e 10% receberam tanto fratura como avulsão dental, 92,8% realizaram o primeiro atendimento e 7,2% encaminharam para outro local e 56,7% relataram sentirem-se seguros para realizar o atendimento. A relação entre a segurança no atendimento com variáveis de perfil e conduta não demonstrou associação estatisticamente significante (p>0,05). Conclusão: Observou-se uma alta prevalência de traumatismo dentário e que muitos profissionais ainda não se sentem seguros para prestarem o atendimento imediato, sendo necessário mais incentivo em cursos na área, visando otimizar a assistência ao paciente com trauma dental.Descritores: Odontólogos; Conhecimento; Traumatismo Dentário.ReferênciasDuarte DA, Bonecker MS, Santanna GR, Suga SS. Caderno de Odontopediatria: Lesões traumáticas em dentes decíduos: Tratamento e Controle. São Paulo: Santos; 2001.Piva F, Potter IG, Sari GT, Klein-Júnior CA, Coelho-De Souza FH. Atendimento de urgência frente ao traumatismo alvéolo dentário – relato de caso clínico. Rev Assoc Paul Cir Dent. 2013;67(3):224-28.Kremer JTM, Pereira LP, Marques FR, Portugal MEG, Bruzamolin, CD. Avaliação do conhecimento dos cirurgiões-dentistas sobre o manejo do trauma dental infantil. Rev Gestão & Saúde. 2017;16(2):1-8.Traebert J, Traiano ML, Armênio R, Barbieri DB, De Lacerda JT, Marcenes W. Knowledge of lay people and dentists in emergency management of dental trauma. Dent Traumatol. 2009;25(3):277-83.Sb-Brasil 2010. Pesquisa Nacional de Saúde Bucal. Proposta de projeto técnico para consulta pública. Brasília; 2010.Skaare AB, Jacobsen I. Primary tooth injuries in Norwegian children (1–8 years). Dent Traumatol. 2005;21(6):15-9.Silva BM, Costa MMA, Almeida CEM, Maia AS, Carvalho OIC, Resende BG. Avaliação do conhecimento da abordagem de trauma dental pelos profissionais de creches. ConScientiae Saude. 2009;8(1):65-73.Andreasen JO, Andreasen FM, Anderson L. Textbook and color atlas of traumatic injuries to the teeth. Hoboken: Wiley-Blackwell; 2013.Torres Silva MC, Díaz YB, Díaz AMB, Figueredo EJ, García YR. Factores predisponentes de trauma dental en escolares del municipio Rafael Freyre. Ccm Holguín. 2017;21(3):798-808.Pádua MN, Mendes FM, Benedetto MS, Volpi NA, Mello-Moura JCI, Bonini GAVC. Prevalência de lesões dentárias traumáticas em pré-escolares de escolas públicas e particulares. J Health Sci Inst. 2010;28(3):237-40.Sanabe EM, Cavalcante BL, Coldebella RC, Abreu-e-Lima BCF. Urgências em traumatismos dentários: classificação, características e procedimentos. Rev Paul Pediatr 2009;27(4):447-51.Wigen TI, Agnalt R, Jacobsen I. Intrusive luxationof permanent incisors in Norwegians aged 6-17 years:a retrospective study of treatment and outcome. Dent Traumatol. 2008;24(3):612-18.Cortes MI, Marcenes W, Sheiham A. Impact of traumatic injuries to the permanent teeth on the oral health-related quality of life in 12-14-year-old children. Community Dent Oral Epidemiol. 2002;30(3):193-98.Pinheiro SAA, Delfino CS. Conhecimento do cirurgião-dentista sobre trauma dentário. Rev cir traumatol buco-maxilo-fac. 2014;14(1):83-90.Granville-Garcia AF, Balduíno Jr JB, Ferreira JMS, Menezes VA, Fontes LBC, Cavalcanti AL. Conhecimento do cirurgião-dentista sobre avulsão dental no Programa de Saúde da Família de Campina Grande- PB/Brasil. Odonto. 2009;17(33):35-41Costa LED, Queiroz FS, Nóbrega CBC, Leite MS, Nóbrega WFS, Almeida ER. Trauma dentário na infância: avaliação da conduta dos educadores de creches públicas de Patos-PB. Rev Odontol UNESP. 2014;43(6):402-8.Hu LW, Prisco CRD, Bombana AC. Knowledge of Brazilian general dentists and endodontists about the emergency management of dentoal­veolar trauma. Dent Traumatol. 2006;22(3):113-17.Leôncio LL, Batista EPC, Nóbrega CBC, Costa LED. Diagnóstico e encaminhamento de pacientes com doenças bucais no serviço público de saúde de Patos-PB: atuação do cirurgião-dentista na referência e contra referência. Arq Odontol. 2015;51(4):210-15.Antunes Drusila P, Antunes Débora P, Chaoubat A, Paula MVQ de, Salgado IO, Coelho, LGC. O conhecimento de cirurgiões-dentistas sobre condutas clínicas nas avulsões e reimplantes dentários: estudo piloto. HU Rev. 2012;38(3,4):135-41.França RI, Traebert J, De Lacerda JT. Brazilian dentists’ knowledge regarding immediate treatment of traumatic dental injuries. Dent Traumatol. 2007;23(5):287-90.Granville-Garcia AF, Menezes VA, Lopes I, Araujo OS, Fontes LBC, Cavalcanti AL. Conduta terapêutica dos cirurgiões-dentistas em relação aos traumatismos dentários. Arq Ciênc Saúde Unipar. 2008;12(3):239-47.Lima DC, Pereira AA, Swerts AA, Fernandes LA. Conduta dos cirurgiões-dentistas de Alfenas/MG frente ao tratamento emergencial de pacientes com avulsão dentária. Arq Odontol. 2013;49(4):169-76.Ribeiro ILA, Melo RTC, Trigueiro DA, Ferreira GS. Conduta clínica de cirurgiões-dentistas de João Pessoa-PB no tratamento endodôntico de dentes com rizogênese incompleta Rev. Odontol Univ Cid São Paulo. 2014;26(3):212-18.Carvalho C, Freire LG, Nakamura V, Gavini G. Possibilidades terapêuticas no tratamento de dentes jovens portadores de polpa viva: revisão de literatura. Rev Ciênc Saúde. 2012;14(1):40-52.Freires IA, Cavalcanti YW. Proteção do complexo dentinipulpar: indicações, técnicas e materiais para uma boa prática clínica. Rev Bras Pesq Saúde. 2011;13(4):69-80.Diangelis AJ, Andreasen JO, Ebeleseder KA, Kenny DJ, Trope M, Sigurdsson A et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 1. Fractures and luxations of permanent teeth. Dent Traumatol. 2012;28(1)2-12.Pereira AC, Silveira VAS, Rosa LEB, Rocha RF. Prescrição medicamentosa em odontopediatria. Rev odontol UNESP. 2009;38(4):256-62.Guimarães S, Moura D, Silva PS. Terapêutica Medicamentosa e Suas Bases Farmacológicas. 5.ed. Porto: Porto Editora, 2006.Andersson L, Andreasen JO, Day P, Heithersay G, Trope M, Diangelis AJ et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol. 2012;28(2):88-96.Trope, M. Clinical management of the avulsed tooth: Present strategies and future directions. Dent Traumatol. 2002;18(1):1-11.Fagundes Ddos, de Mendonça IL, de Albuquerque MT, Inojosa Ide F. Spontaneous healing responses detected by cone‐beam computed tomography of horizontal root fractures: a report of two cases. Dent Traumatol. 2014;30(6):484-87.Mankar N, Jogad N, Chute A, Patil S, Gade V, Mohkar S. Management of horizontal root fracture: two case reports. IOSR J Dent Med Sci. 2014;13(4):1-4.Kinirons MJ, Gregg TA, Welbury RR, Cole BO. Variations in the presenting andt treatment features in reimplant permanent incisors in children and their effect on the prevalence of root resorption. Br Dent J. 2000;189(5):263-66.Panzarini SR, Gulineli JL, Poi WR, Sonoda CK, Pedrini D, Brandini DA. Treatment of root surface in delayed tooth replantation: a review of literature. Dent Traumat. 2008;24(3):277-82.

In recent years, steel components manufactured through additive manufacturing have increased their popularity and commercial importance and carbon fiber reinforced polymers are widely used in today’s society. Yet there is no composite material combining the properties of steel and carbon fibers. This thesis work is a part of the World Class Material-project at Swerim AB where different methods for manufacturing a steel matrix carbon fiber composite are researched upon. Two methods for additive manufacturing: selective laser melting and electron beam melting were used to evaluate the possibility of creating a steel matrix carbon fiber composite. The experiment with electron beam melting was conducted without powder and the two selective laser melting experiments were conducted with powder using fibers with organic and metal coating respectively. The main aspect evaluated was the survival of carbon fibers during processing. The results showed no intact carbon fibers after processing organically sized fibers in either of the processes. In the selective laser melting experiment with organic coating, big voids were found where the fiber bundles had been placed, showing no infiltration of powder or molten metal into the bundle prior to fiber breakdown. The metal-coated fibers survived partially but showed poor infiltration of matrix material into the carbon fiber bundle. The methods used in this report were not found suitable for the manufacturing of steel matrix carbon fiber composites.
De senaste åren har additiv tillverkning av stålkomponenter blivit alltmer populärt och kolfiberarmerade polymerer används i stor utsträckning i dagens samhälle. Trots det finns det i nuläget inget kompositmaterial som kombinerar stål och kolfiber. Detta kandidatexamensarbete har varit en del av World Class Material-projektet på Swerim AB, där olika metoder för tillverkning av en kolfiberkomposit med stålmatris undersöks. Två additiva tillverkningsmetoder, selective laser melting (SLM) och electron beam melting (EBM), användes för att utvärdera möjligheten att med dessa tillverka en stål-och kolfiberkomposit. Testet i EBM genomfördes utan pulver och i testerna SLM med pulver där fibrerna i ena försöket hade kvar sin organiska ytbeläggning och en metallbeläggning i det andra försöket. Den huvudsakliga aspekten som undersöktes var kolfibrernas förmåga att klara tillverkningsmiljön. Det förekom inga intakta kolfiber efter processen i försöken med EBM och SLM med den organiska ytbeläggningen. Beträffande SLM-försöket, påträffades även stora håligheter där kolfiber befunnit sig, vilket visade på en bristfällig impregnering av fibrerna innan deras nedbrytning. Fibrerna som var belagda med en metall överlevde framställningsprocessen i en större utsträckning, men impregnationen var fortfarande bristfällig. Metoderna som undersöktes i denna rapport var sålunda inte lämpliga för att tillverka en kolfiberkomposit med stålmatris.

This master thesis was done at Swerim AB in cooperation with SSAB and the Technical University of Luleå in the purpose of preventing spalling problems in hot rolling mills. Spallings are a fatigue damage that occurs on the rolls due to extreme loads and unfavorable conditions between the rolls in a mill. This report describes how the roughing mill, which is the first of a series of hot rolling mills is modelled and simulated in order to compute and improve the load distribution between the rolls. The load distribution tells a lot where the spalling problems occurs. By computer aided design and simulations with the finite element method a parametric computational model was created and used to simulate the load distribution between the work roll and backup roll with worn andfresh rolls. These simulations showed what the load distribution looks like when using new rolls and that the load distribution is especially bad when the work roll is worn. The computational model was used to simulate how the load distribution changes with different geometries on the backup roll to provide valuable input and suggest new designs on the backup roll currently used by SSAB Borlänge.