Dissertationen zum Thema „Susceptibilité au stress“
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Merlot, Elodie. „Modulation de la production de cytokines par l'environnement social et susceptibilité aux infections“. Paris, Institut national d'agronomie de Paris Grignon, 2003. https://pastel.archives-ouvertes.fr/pastel-00000790.
Der volle Inhalt der QuelleIn social species, social environment contributes to the development and expression of diseases. Indeed, the social position in a group modulates susceptibility to infections. However, the endocrine and immune mechanisms involved in these differences are not known. Furthermore, instability in the social organisation generates a severe stress of which immune consequences are still controversial. The purposes of this thesis are (1) to describe the influence of social status on the endocrine and immune systems, (2) to specify the effects of social stress on cytokine production and susceptibility to infections and (3) to look for possible sources of variability in the immune consequences of social stress. Excepted a single study on piglets, experiments were performed in mice. Results show an influence of social status. In the absence of stress, dominants show higher basal corticosterone levels and specific response to tuberculin than subordinates. After social defeat, dominants are more affected. Social defeat increases inflammatory reactivity but does not clearly modify the balance between Th1 and Th2 cytokines production and does not affect the development of specific immunity against a mycobacterial infection. Immune effects of social defeat can be observed only when the stress involves significant fights and injuries. Our work also shows that the response to stress depends on individual social experience, in particular on social status, and on the recent immune experience of the individual
Blein, Sophie. „Étude de la variabilité du génome mitochondrial comme facteur de susceptibilité au cancer du sein“. Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10240/document.
Der volle Inhalt der QuelleA large part of the genetic component of breast cancer risk (BCR) is still unexplained. Therefore I studied if variants of the mitochondrial genome (mtDNA) might explain a part of this risk. In fact, mitochondria is the main source of reactive oxygen species (ROS), which contribute to genomic instability and tumor development. As a first axis of research, I studied potential interactions between some nuclear and mitochondrial variants, in conjugation to alcohol consumption. Despite the large dimensions of our dataset, the lack of statistical significant interaction in our data might reveal that former published results that show such interactions were not robust. I also studied if mitochondrial haplogroups could be considered as modificators of known association between BCR and pathogenic mutations in the BRCA1/2 genes. I identified haplogroup T1a1 such as modificator for individuals carrying a mutated BRCA2. Finally, I characterized by NGS mitochondrial genome of women diagnosed for a familial breast cancer, but tested negative for known pathogenic BRCA1/2 mutations. Several variants were identified as potentially damaging. Two genes, MT-ATP6 and MT-CYB are specifically enriched both in terms of distinct variants and in the number of individuals carrying these variants. They are both essential structural components of the mitochondrial respiratory chain, the main ROS production source in the cell. All these analyses contribute to enrich the knowledge about associations between BCR and variability of mtDNA, by integrating questions linked to interactions between genomic variants, environmental exposure, and effect modifications related to mitochondrial haplogroups
Rakotobé, Malalaniaina. „Bases neuro-développementales de la susceptibilité à l’anxiété : apports de l’étude du système habénulo-interpédonculaire“. Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://www.theses.fr/2021COAZ6002.
Der volle Inhalt der QuelleReward circuits of the brain are neuronal networks that modulate positively or negatively the motivation to act according to the situation. They are essential for the survival of the subject and of species by selecting the appropriate behaviors, such as fleeing the danger or searching for food. Dysfunctions of these circuits can lead to mood disorders and addictions. Although these psychiatric disorders can emerge in adulthood, according to the neurodevelopmental hypothesis they can find their origins at a much earlier stage. Indeed, there are periods of development, called critical periods of development, during which genetic and environmental factors influence the maturation of neuronal circuits. A stressful environment and/or defaults in the expression of developmental genes during these critical periods can lead to the malformation of neuronal circuits, including the reward circuits, creating a predisposition to psychiatric disorders. The habenulo-interpeduncular system (HIPS), composed of the medial habenula (MHb) and its main target, the interpeduncular nucleus (IPN), emerges as a key component of the reward circuits. It is notably involved in disorders such as addiction, anxiety and depression. Our team has recently identified the Otx2 transcription factor as an essential genetic factor for the formation of the MHb and IPN. Otx2 expression is maintained in the HIPS throughout life, strongly in the last neurons generated in the MHb (Otx2High neurons) and in neurons of the lateral and central subnucleus of the caudal IPN, suggesting that it might also play a role in the maturation and functioning of the HIPS. We already know that in the ventral tegmental area (VTA), another actor of the reward circuits, a chronic stress, endured during a specific period of childhood decreases the expression level of Otx2 and predisposes to depression and anxiety. It is thus possible that Otx2 might play a similar function in the HIPS response to stress during periods of development. This thesis work aimed to better understand how genetic and environmental factors affecting the development of the HIPS could lead to the development of psychiatric disorders.The first part of this thesis shows that Otx2High neurons of the MHb project on the Otx2+ neurons of the IPN, revealing an Otx2-dependant sub-circuit in the HIPS. The MHb was then chemogenetically activated with the use of DREADD to verify that Otx2High neurons of the MHb are indeed able to modulate the activity of the Otx2+ neurons of the IPN and confirmed the idea that these neurons constitute a sub-circuit of the HIPS, labelled with the expression of Otx2, that we will call the HIPOPS (Habenulo-InterPeduncular-Otx2-Positive-System).In the second part of this project, a critical period of development during which the HIPS is more sensitive to stress has been searched. By using Fos and Egr1, two neuronal markers of activity, we identified a preadolescent period during which the HIPS is more responsive to chronic stress. Interestingly, that chronic stress involves more particularly the activity of the HIPOPS, emphasizing the implication of that sub-circuit in the stress response.In the third part, a “2-hit” stress protocol of chronic stress has been developed and revealed that a chronic stress endured during preadolescence predisposes to anxiety but not to depression in the long-term. In the last part, the effects of Otx2 conditional deletion in the HIPS has been assessed. This study shows that Otx2 deletion in the MHb protects from the deleterious effects of preadolescent chronic stress on anxiety symptoms. This work, therefore, demonstrates that the interaction between environment (stress) and genes (Otx2) during preadolescence determines the susceptibility to develop chronic anxiety in the long term and that one of the cellular support of that susceptibility is the HIPOPS, a circuit lodged inside the HIPS, recognizable by Otx2 expression
Moulin, Sophie. „Rôle de l'hypoxia-inducible factor-1 dans la susceptibilité myocardique à l'ischémie-reperfusion induite par l'hypoxie intermittente“. Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV034/document.
Der volle Inhalt der QuelleObstructive sleep apnea syndrome (OSAS) is a major public health problem that is considered an independent risk factor for the occurrence of myocardial infarction (MI). The cardiovascular alterations associated with OSA are mainly due to the chronic intermittent hypoxia (IH). In particular, activation by IH, the hypoxia-inducible factor-1 (HIF-1) transcription factor likely contributes to enhance myocardial vulnerability to ischemia-reperfusion injury. The aim of this thesis was to study the role of HIF-1 in the mechanisms involved in the increase in MI induced by chronic IH. This work has highlighted two new deleterious consequences of IH exposure, namely endoplasmic reticulum (ER) stress and mitochondrial alterations. Through genetic and/or pharmacological inhibition of HIF-1, we have shown that HIF-1 appears to be a primordial actor in all the deleterious mechanisms of IH, including those discovered during this thesis. HIF-1 also appears to play a major role in the IH-induced increase in MI size. In parallel, its myocardial activation is correlated with the apnea-hypopnea index in apnoeic, compared to non-apnoeic, patients with coronary heart disease. Therefore, HIF-1 activation could serve as a diagnostic marker of OSA in patients with cardiovascular risk. HIF 1 could also be a target for new therapeutic approaches, in complement or replacement of standard treatments
Le, guernic Antoine. „Effets sublétaux d'une contamination métallique liée à des rejets miniers uranifères sur l'épinoche à trois épines (Gasterosteus aculeatus L.). Implication dans la susceptibilité envers un stress biologique“. Thesis, Reims, 2015. http://www.theses.fr/2015REIMS027.
Der volle Inhalt der QuelleUranium extraction has resulted in a remobilisation of this actinide into mine surrounding ecosystems. Uses of metal salts during mining site rehabilitation, and the natural presence of metals have increased the metal contamination in hydrosystems submitted to mine tailings.In situ experiments were conducted in two former French uranium mining sites. Three-spined stickleback caging was used to determine the sublethal effects of this metal mixture on this freshwater fish, as well as its effects on fish susceptibility to a sudden biological stress.This pollution, characterised by higher metal concentrations (especially for uranium), has led to an oxidative stress in sticklebacks visible through several biomarkers, and other effects dependent on the study site. The polymetallic contamination has modified the stickleback responses to the biological stress, by preventing their phagocytic and antioxidant responses. This work has reinforced the interest of the caging technique during environmental studies and that of immunomarkers in a multi-biomarker approach
Pujol, Marine. „Variabilité comportementale en réponse au stress social : influence du variant allélique VGLUT3-p.T8I sur l'acétylcholine et la dopamine dans le noyau accumbens“. Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS098.
Der volle Inhalt der QuelleStress is a risk factor for the development of psychiatric conditions such as generalized anxiety and major depressive disorder which are often associated with sleep disturbances. The behavioral adaptation to stress is influenced by a combination of environmental and genetic factors, leading to significant variability among individuals. The nucleus accumbens (NAc) plays a critical role in stress susceptibility and sleep regulation. In the NAc, the behavioral adaptations associated with resilience or susceptibility to stress are modulated by dopamine (DA) and acetylcholine (ACh) signals. The latter is predominantly released by cholinergic interneurons (CINs). Notably, CINs have the ability to signal with both ACh and glutamate through the expression of vesicular acetylcholine transporter (VAChT) and vesicular glutamate transporter 3 (VGLUT3). Our lab recently showed that the VGLUT3-p.T8I allelic variant results in a reduced ACh release from CINs without affecting glutamate release.The objective of my PhD was to elucidate the role of the p.T8I variant in shaping behavioral and sleep responses to stress as well as the stress-associated neuronal ACh and DA dynamics in the NAc. To address these questions, I took advantage of a mouse line carrying the p.T8I variant (VGLUT3T8I/T8I) to study social, anxiety- and depressive-like behaviors as well as sleep-wake patterns in male and female mice both before and after chronic social defeat stress (CSDS) exposure. Then, I measured in vivo ACh and DA dynamics in the NAc using fiber photometry coupled with fluorescent biosensors to assess their release in response to stress. The findings indicate that the p.T8I variant is associated with enhanced social cue discrimination characterized by high target-dependent social avoidance, and elevated anxiety-like levels, accompanied by distinct acute stress-induced sleep changes. Moreover, these behaviors are associated with reduced stress-induced ACh release in the NAc in male mice. Together, these findings reveal the intricate relationship between the p.T8I variant, diminished cholinergic transmission within the NAc and susceptibility to stress
Etain, Bruno. „Contribution à l'étude des facteurs génétiques et environnementaux de susceptibilité aux troubles bipolaires : études du trouble bipolaire à début précoce et des traumatismes affectifs de l’enfance“. Thesis, Paris Est, 2009. http://www.theses.fr/2009PEST0048.
Der volle Inhalt der QuelleBipolar disorders (BD) are psychiatric diseases with a complex determinism in which genetic and environmental susceptibility factors are involved. Attempts to identify genetic factors have produced conflicting results and environmental factors remain unknown. Early-onset bipolar disorder (EO-BD) is a clinical entity that is characterized by a strong familial aggregation ; a specific focus on this subtype might facilitate the identification of susceptibility genes. A genome-wide scan in EO-BD has suggested eight regions of linkage (chromosomal regions 2p21, 2q14, 3p14, 5q33, 7q36, 10q23, 16q23 and 20p12). We have demonstrated an association between EO-BD and the SNAP25 gene (located at 20p12 and involved in exocytosis). We have demonstrated an association between BD and the ASMT gene (involved in the synthesis of melatonin). Finally, a genome-wide association study has suggested the involvement of two phosphatidyl-inositol pathway related genes in the susceptibility to EO-BD (PLEKHA5 et PLCXD3). Concerning environmental susceptibility factors, childhood affective traumatic events (mainly emotional abuse) are associated with BD, might influence two core dimensions of BD (affective lability and affect intensity) and might interact with the serotonin transporter genelinked polymorphic region to modulate the age of onset of the disorder. These studies illustrate the relevance of focusing on the early onset subgroup of the disease to identify susceptibility genes, the need to further explore early stressors as environmental factors associated with BD and to investigate the complex relationships between these two kinds of susceptibility factors
Jones, C. A. „A study of stress susceptibility in pigs“. Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372043.
Der volle Inhalt der QuelleThomas, Gladys Ruth. „Susceptibility of Brugia malayi to oxidative and nitrosative stress“. Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267808.
Der volle Inhalt der Quelle鍾慧虹 und Wai-hung Angela Chung. „Cognitive vulnerability, stress, and postpartum depressive symptomatology: a prospective study in HongKong“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37101055.
Der volle Inhalt der QuelleShushan, S. M. „The susceptibility of diffusion bonded joints to stress corrosion cracking“. Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295046.
Der volle Inhalt der QuelleChung, Wai-hung Angela. „Cognitive vulnerability, stress, and postpartum depressive symptomatology a prospective study in Hong Kong /“. Click to view E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37101055.
Der volle Inhalt der QuelleLorho, Nina. „Stress corrosion cracking susceptibility in Alloy 600 with different strain histories“. Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/stress-corrosion-cracking-susceptibility-in-alloy-600-with-different-strain-histories(59eabd1d-b254-48bc-afca-e979f5d4e6c2).html.
Der volle Inhalt der QuelleSivathayalan, Sivapathasundaram. „Fabric, initial state and stress path effects on liquefaction susceptibility of sands“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0017/NQ56623.pdf.
Der volle Inhalt der QuelleAnyanwu, Ezechukwu John. „Low Alloy Steel Susceptibility to Stress Corrosion Cracking in Hydraulic Fracturing Environment“. University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398948610.
Der volle Inhalt der QuelleStrader, Katherine C. „Phase Transformation Behavior and Stress Relief Cracking Susceptibility in Creep Resistant Steels“. The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408973568.
Der volle Inhalt der QuelleRozentals, Emils. „Email load and stress impact on susceptibility to phishing and scam emails“. Thesis, Luleå tekniska universitet, Digitala tjänster och system, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-85403.
Der volle Inhalt der QuellePisu, Davide. „ROLE OF SigE IN M.TUBERCULOSIS DRUG SUSCEPTIBILITY AND PERSISTENCE“. Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424157.
Der volle Inhalt der QuelleM.tuberculosis (Mtb) è uno dei patogeni più importanti che infettano gli essere umani ed è l’agente eziologico della tubercolosi (TB), una malattia che risale a tempi antichi. L’Organizzazione Mondiale della Sanità (OMS) stima che più di un terzo dell’intera popolazione mondiale sia stata infettata da Mtb e che ogni anno circa 1,5 milioni di persone muoiano di tubercolosi. Due dei principali problemi nel controllo di questa malattia sono l’enorme serbatoio di portatori latenti e la lunghezza del trattamento terapeutico. Una spiegazione condivisa relativamente alla necessità di un trattamento terapeutico prolungato è che la totalità o una parte della popolazione batterica, nel corso di un’infezione, entri in uno stato non replicativo, caratterizzato da un certo grado di “dormienza”. Queste cellule quiescenti sono chiamate “persisters”. Questo fenomeno, la cui fisiologia non è ben nota, è molto importante per il trattamento delle infezione, in considerazione del fatto che le cellule dormienti sono tolleranti ad alte concentrazioni di molti farmaci e perciò non vengono da essi uccise. Lo scopo di questo studio è stato pertanto quello di trovare nuovi potenziali bersagli molecolari che possano essere utilizzati per migliorare l’efficacia dei trattamenti terapeutici tradizionali, al fine di sviluppare nuove terapie efficaci contro questa popolazione di cellule persistenti. I fattori sigma (σ) regolano l’espressione genica legandosi all’apoproteina polimerasica e, in futuro, potrebbero essere importanti bersagli molecolari di nuovi approcci terapeutici, in quanto alcuni recenti studi hanno dimostrato come essi potrebbero avere un ruolo chiave nel fenomeno della persistenza di M.tuberculosis. In questo lavoro ci siamo concentrati su uno di questi fattori sigma in particolare, SigE, che era stato descritto in precedenza nel giocare un ruolo di primaria importanza nella risposta ai diversi tipi di stress che Mtb incontra durante un’infezione, come shock termico, stress di superficie e ossidativo. (Manganelli et al., 2001). Utilizzando un mutante di delezione per sigE e, attraverso una serie di indagini molecolari e fenotipiche, siamo stati in grado di dimostrare come SigE rivesta un ruolo cruciale nella risposta ai diversi tipi di stress causati dall’esposizione a differenti classi di farmaci antibatterici. Inoltre, abbiamo osservato una forte riduzione nella produzione di cellule “persister” quando il mutante sigE è stato esposto ad elevate concentrazioni di farmaci antimicrobici. Infine, per verificare se queste caratteristiche fossero condivise tra i fattori sigma, abbiamo testato altri mutanti per differenti fattori sigma. Nonostante siamo stati in grado di dimostrare che anche sigB (la cui espressione è controllata da sigE in condizioni di stress) sia coinvolto nella produzione di cellule persistenti, tuttavia la maggior parte delle caratteristiche molecolari e fenotipiche che abbiamo descritto in questo lavoro sono attribuibili al solo fattore SigE. Per concludere, con questo lavoro siamo stati in grado di dimostrare come SigE possa essere un valido bersaglio molecolare per lo sviluppo di nuove terapie efficaci contro le infezioni causate da M.tuberculosis.
Smith, Vincent Peter. „The cuticular membranes of parasitic nematodes : structure, composition and susceptibility to oxidative stress“. Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267287.
Der volle Inhalt der QuelleStenerud, Gaute. „The Susceptibility to Hydrogen Induced Stress Cracking for Alloy 718 and Alloy 725“. Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for materialteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26331.
Der volle Inhalt der QuelleAraujo, Alessandra M. „STRESS RESPONSES AND PACE OF LIFE PHENOTYPES PREDICT DISEASE SUSCEPTIBILITY AND HOST EPIZOOTIC POTENTIAL“. OpenSIUC, 2015. https://opensiuc.lib.siu.edu/theses/1773.
Der volle Inhalt der QuelleCullen, Alexis Elizabeth. „Increased stress susceptibility and hypothalamic-pituitary-adrenal axis dysfunction : early markers of psychosis vulnerability?“ Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/increased-stress-susceptibility-and-hypothalamicpituitaryadrenal-axis-dysfunction(b602f1f0-1006-4491-a112-83d5156f8e13).html.
Der volle Inhalt der QuelleChen, Jinwei. „The effects of specimen geometry of susceptibility to stress corrosion cracking (SCC) of steels“. Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270796.
Der volle Inhalt der QuelleCoulthard, Jacob, Westley Ongtengco, Jacob Garst, Michelle Chandley, Hui Wang-Heaton und Gregory A. Ordway. „Oxidative Stress Susceptibility of Oligodendrocytes in Major Depressive Disorder is Widespread in the Brain“. Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/47.
Der volle Inhalt der QuelleWodarcyk, John J. „Stress corrosion cracking susceptibility of AISI no. 1018 steel in low SO₂-CO₂-O₂ aqueous environments“. Ohio : Ohio University, 1991. http://www.ohiolink.edu/etd/view.cgi?ohiou1183988473.
Der volle Inhalt der QuelleRoberts, Susan. „The effect of dietary protein source on plasma parameters related to stress and behaviour in pigs varying in their susceptibility to stress /“. Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56819.
Der volle Inhalt der QuelleLeech, Alexandra. „Struggling with susceptibility and stress : an exploration and expansion of vulnerability-stress models of depression and the potential for intervention in late adolescence“. Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608286.
Der volle Inhalt der QuelleSkjönsberg, Åsa. „Hereditary susceptibility to inner ear stress agents studied in heterozygotes of the German waltzing guinea pig /“. Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-817-7/.
Der volle Inhalt der QuelleWodarcyk, John J. Jr. „Stress corrosion cracking susceptibility of AISI No. 1018 steel in low SO 2CO 2O 2aqueous environments“. Ohio University / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1183988473.
Der volle Inhalt der QuelleSherwood, Patrick William. „Biochemical Mechanisms of Resistance and Susceptibility in the Pinus nigra - Diplodia sapinea Pathosystem“. The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408640310.
Der volle Inhalt der QuelleGarry, Michael R. „Differential response and susceptibility to oxidative stress in mouse lung fibroblasts heterozygous for phospholipid hydroperoxide glutathione peroxidase (GPx4) /“. Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8465.
Der volle Inhalt der QuelleBeal, Irina. „Event Sedimentology and Hydrodynamic Hindcasting of Storm Surge Deposits: Hurricane Sandy, New Jersey“. Master's thesis, Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/281770.
Der volle Inhalt der QuelleM.S.
The impact of Hurricane Sandy (October 2012) on the Atlantic Coast of the United States resulted in massive overtopping (aggradation) of coastal barriers, along with localized overwash and breaching. A combination of high-frequency ground-penetrating radar (800 MHz GPR), low-field magnetic susceptibility (MS), and textural and mineralogical analyses was used to reconstruct the sedimentological and hydrodynamic parameters of the storm surge at two New Jersey sites immediately north of hurricane landfall: 1) Mantoloking and 2) Island Beach State Park (IBSP). Mantoloking represents a developed, scour-channelized backdune area with a 30-60 cm thick deposit consisting of 20-23 event horizons. Geophysical images reveal gently landward-dipping reflections. In contrast, IBSP site is a broad (width: 40 m) vegetated dune swale. GPR transects show landward-dipping tangential-oblique reflections as well as a conformable channel cut-and-fill structure (width: 7 m; depth: 1.5 m), producing a 0.7-1.5-m-thick deposit with 24-30 horizons. Within each sand-dominated event horizon, an upward 5-15% increase in mean grain size and 80-100% decrease in MS highlight the importance of hydrodynamic equivalency in lithological segregation within mixed-density fractions. Basal sub-layers enriched in heavy minerals (magnetite, ilmenite, garnet) yield MS of 100-350 μSI, in contrast to <40 μSI in quartz-rich upper sub-layers and pre-storm deposits. Several peaks in MS values correspond to an up to 65% increase in threshold shear stresses associated with individual unidirectional surge flows, with several most-enriched event horizons likely corresponding to waning-stage storm surge peaks recorded by offshore buoys. The sharp contact with the pre-storm surface produces distinct GPR reflections that allow accurate mapping of the thickness and extent of hurricane deposits. Together with potential correlation between lithological anomalies and high amplitude georadar signal return, the approach used in this study has applications to reconstructing event deposits in Quaternary sedimentary records. The new research findings have potential implications for reconstructing surge dynamics of recent hurricane events as well as quantitative hindcasting of hydrodynamic conditions responsible for lithologically diverse intervals in ancient tempestites.
Temple University--Theses
Beal, Irina. „Beal_Calculations.xls“. Master's thesis, Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/281771.
Der volle Inhalt der QuelleM.S.
The impact of Hurricane Sandy (October 2012) on the Atlantic Coast of the United States resulted in massive overtopping (aggradation) of coastal barriers, along with localized overwash and breaching. A combination of high-frequency ground-penetrating radar (800 MHz GPR), low-field magnetic susceptibility (MS), and textural and mineralogical analyses was used to reconstruct the sedimentological and hydrodynamic parameters of the storm surge at two New Jersey sites immediately north of hurricane landfall: 1) Mantoloking and 2) Island Beach State Park (IBSP). Mantoloking represents a developed, scour-channelized backdune area with a 30-60 cm thick deposit consisting of 20-23 event horizons. Geophysical images reveal gently landward-dipping reflections. In contrast, IBSP site is a broad (width: 40 m) vegetated dune swale. GPR transects show landward-dipping tangential-oblique reflections as well as a conformable channel cut-and-fill structure (width: 7 m; depth: 1.5 m), producing a 0.7-1.5-m-thick deposit with 24-30 horizons. Within each sand-dominated event horizon, an upward 5-15% increase in mean grain size and 80-100% decrease in MS highlight the importance of hydrodynamic equivalency in lithological segregation within mixed-density fractions. Basal sub-layers enriched in heavy minerals (magnetite, ilmenite, garnet) yield MS of 100-350 μSI, in contrast to <40 μSI in quartz-rich upper sub-layers and pre-storm deposits. Several peaks in MS values correspond to an up to 65% increase in threshold shear stresses associated with individual unidirectional surge flows, with several most-enriched event horizons likely corresponding to waning-stage storm surge peaks recorded by offshore buoys. The sharp contact with the pre-storm surface produces distinct GPR reflections that allow accurate mapping of the thickness and extent of hurricane deposits. Together with potential correlation between lithological anomalies and high amplitude georadar signal return, the approach used in this study has applications to reconstructing event deposits in Quaternary sedimentary records. The new research findings have potential implications for reconstructing surge dynamics of recent hurricane events as well as quantitative hindcasting of hydrodynamic conditions responsible for lithologically diverse intervals in ancient tempestites.
Temple University--Theses
Beal, Irina. „Beal_CAMSIZERdata.xlsx“. Master's thesis, Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/281772.
Der volle Inhalt der QuelleM.S.
The impact of Hurricane Sandy (October 2012) on the Atlantic Coast of the United States resulted in massive overtopping (aggradation) of coastal barriers, along with localized overwash and breaching. A combination of high-frequency ground-penetrating radar (800 MHz GPR), low-field magnetic susceptibility (MS), and textural and mineralogical analyses was used to reconstruct the sedimentological and hydrodynamic parameters of the storm surge at two New Jersey sites immediately north of hurricane landfall: 1) Mantoloking and 2) Island Beach State Park (IBSP). Mantoloking represents a developed, scour-channelized backdune area with a 30-60 cm thick deposit consisting of 20-23 event horizons. Geophysical images reveal gently landward-dipping reflections. In contrast, IBSP site is a broad (width: 40 m) vegetated dune swale. GPR transects show landward-dipping tangential-oblique reflections as well as a conformable channel cut-and-fill structure (width: 7 m; depth: 1.5 m), producing a 0.7-1.5-m-thick deposit with 24-30 horizons. Within each sand-dominated event horizon, an upward 5-15% increase in mean grain size and 80-100% decrease in MS highlight the importance of hydrodynamic equivalency in lithological segregation within mixed-density fractions. Basal sub-layers enriched in heavy minerals (magnetite, ilmenite, garnet) yield MS of 100-350 μSI, in contrast to <40 μSI in quartz-rich upper sub-layers and pre-storm deposits. Several peaks in MS values correspond to an up to 65% increase in threshold shear stresses associated with individual unidirectional surge flows, with several most-enriched event horizons likely corresponding to waning-stage storm surge peaks recorded by offshore buoys. The sharp contact with the pre-storm surface produces distinct GPR reflections that allow accurate mapping of the thickness and extent of hurricane deposits. Together with potential correlation between lithological anomalies and high amplitude georadar signal return, the approach used in this study has applications to reconstructing event deposits in Quaternary sedimentary records. The new research findings have potential implications for reconstructing surge dynamics of recent hurricane events as well as quantitative hindcasting of hydrodynamic conditions responsible for lithologically diverse intervals in ancient tempestites.
Temple University--Theses
Chen, Yuanneng. „Role of polymorphisms in genes affecting oxidative stress and immune response in susceptibility to alcoholic liver disease“. Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391248.
Der volle Inhalt der QuelleSanchez, Camacho Lizeth J. „"Effect of AC interference on the corrosion cracking susceptibility of low carbon steel under cathodic protection."“. University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1531157966071788.
Der volle Inhalt der QuelleAhmed, Ismaila Idowu. „The influence of material factors, including cold work, on the susceptibility of stainless steels to stress corrosion cracking“. Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-influence-of-material-factors-including-cold-work-on-the-susceptibility-of-stainless-steels-to-stress-corrosion-cracking(19937317-f1b4-4dbc-ab0e-3eab3760f716).html.
Der volle Inhalt der QuelleHartley, Deborah Jean. „Anxiety and depression: An empirical investigation of the Diathesis-Stress Model of psychopathology“. CSUSB ScholarWorks, 1999. https://scholarworks.lib.csusb.edu/etd-project/1849.
Der volle Inhalt der QuelleTaniguchi, Masayuki. „Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice“. Kyoto University, 2018. http://hdl.handle.net/2433/232116.
Der volle Inhalt der QuelleGonzalez, Gabriel. „Alterations in Fatty Acid Amide Hydrolase (Faah) Transcript Levels and Activity Lead to Changes in the Abiotic Stress Susceptibility of Arabidopsis Thaliana“. Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc115085/.
Der volle Inhalt der QuelleCevik, Gul. „Investigation Of The Effect Of Orientation And Heat Treatment On The Stress Corrosion Cracking Susceptibility Of 7050 Aluminum Alloy“. Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12605220/index.pdf.
Der volle Inhalt der QuelleDuff, Jonathon Andrew. „The influence of grain boundary structure in proton irradiated stainless steel on susceptibility to irradiation assisted stress corrosion cracking“. Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496690.
Der volle Inhalt der QuelleDella, Roverys Coseglio Mario Sergio. „Susceptibility of low-temperature plasma nitrided 17-4 PH (H1150D) to sulphide stress cracking (SSC) in typical oilfield environment“. Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8488/.
Der volle Inhalt der QuelleHilton, Bruce A. „Irradiation assisted stress corrosion cracking susceptibility of low fluence stainless steels evaluated by in-flux slow strain rate tests“. Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/42810.
Der volle Inhalt der QuelleSmith, Brian Donald. „The influence of high temperature stress and herbicides on the susceptibility of creeping bentgrass (Agrostis palustris) to Curvularia lunata“. Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/74538.
Der volle Inhalt der QuelleMaster of Science
Rojas-Rudolph, Isolde Gina. „Stress modulation of susceptibility to wound infection : effects on Leukocyte Trafficking and Chemokine Gene Expression during Cutaneous Wound Healing /“. The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486474078047403.
Der volle Inhalt der QuelleTanaka, Kohei. „Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway is Critical for Susceptibility to Repeated Social Defeat Stress in Mice“. Kyoto University, 2012. http://hdl.handle.net/2433/158067.
Der volle Inhalt der QuellePALADINI, MARIA SERENA. „STRESS EXPOSURE ACROSS LIFESPAN SHAPES THE CNS SUSCEPTIBILITY TO FURTHER ADVERSE EVENTS: PRECLINICAL EVIDENCE USING A DOUBLE HIT APPROACH“. Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/694054.
Der volle Inhalt der QuelleMartínez, Membrives Esther. „Susceptibility to experimental autoimmune encephalomyelitis (model of multiple sclerosis) and anxiety in genetically heterogeneous rats“. Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/123299.
Der volle Inhalt der QuelleStress hypothalamic-pituitary-adrenal (HPA) axis responses play a role in both anxiety behaviour and immune system (IS). Enhanced glucocorticoid (GC) levels have shown to play a protective role in experimental autoimmune encephalomyelitis (EAE), a reliable animal model of multiple sclerosis. In this Thesis, we aimed to investigate if a determined anxious profile could correspond to a specific inflammatory susceptibility. In “Study I”, genetically heterogeneous N/Nih-HS rats of both sexes were immunized with myelin oligodendrocyte glycoprotein (MOG) to evaluate EAE. To assess the effect of anxiety on IS, subgroups of rats scoring extreme values of anxiety were examined on their EAE incidence (INC) and severity. Also, anxious behaviour and relative adrenal weight (RAW) of subgroups selected by resistance or susceptibility was studied was compared. Results indicated a possible relationship between high anxiety and EAE-resistance. However, the assumed associations between behavioural anxiety and physiological stress needed to be elucidated. Thus, in “Study II” we studied in male and female DA and PVG inbred rats the possible relationships among HPA axis responses and anxiety. DA and PVG strains are respectively susceptible and resistant to a wide range of experimental autoimmune diseases, EAE among others. In the current study, these strains were characterized by their anxiety/inhibition. We further examined their HPA axis function, by means of (basal and post-stress) corticosterone levels, RAW, and via RT–PCR their expression of mRNA adrenocorticotropin receptor (Melanocortin 2 Receptor, MC2R) on adrenal glands. We also studied the mRNA expression of both CD74 (major histocompatibility complex; MHC-II) and the pro-inflammatory interleukin-6 (IL-6) on paraventricular nucleus of the hypothalamus (PVN), pituitary and adrenal glands. Together, our data show that in EAE, a high anxious profile accompanied by an enhanced HPA axis may involve the repression of inflammatory responses, providing a certain resistance.
Hedborg, Kerstin. „Migraine and Stress : An Internet administered Multimodal Behavioral Treatment Intervention“. Doctoral thesis, Uppsala universitet, Medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158079.
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