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1

Alonso, Ariel. Applied Surrogate Endpoint Evaluation Methods with SAS and R. Boca Raton : CRC Press, 2017.: Chapman and Hall/CRC, 2016. http://dx.doi.org/10.1201/9781315372662.

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2

Forrester, Alexander I. J. Surrogate models in engineering design: A practical guide. Chichester, West Sussex, England: J. Wiley, 2008.

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3

Molenberghs, Geert, Marc Buyse, Tomasz Burzykowski, Ariel Alonso und Theophile Bigirumurame. Applied Surrogate Endpoint Evaluation Methods with SAS and R. Taylor & Francis Group, 2016.

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4

Applied Surrogate Endpoint Evaluation Methods with SAS and R. Taylor & Francis Group, 2016.

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5

Applied Surrogate Endpoint Evaluation Methods with SAS and R. Taylor & Francis Group, 2016.

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6

Molenberghs, Geert, Marc Buyse, Tomasz Burzykowski, Ariel Alonso und Theophile Bigirumurame. Applied Surrogate Endpoint Evaluation Methods with SAS and R. Taylor & Francis Group, 2016.

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7

Molenberghs, Geert, Marc Buyse, Tomasz Burzykowski, Ariel Alonso und Theophile Bigirumurame. Applied Surrogate Endpoint Evaluation Methods with SAS and R. Taylor & Francis Group, 2016.

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8

Alonso, Ariel. Applied Surrogate Endpoint Evaluation Methods with SAS and R. Taylor & Francis Group, 2020.

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9

Huffaker, Ray, Marco Bittelli und Rodolfo Rosa. Entropy and Surrogate Testing. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198782933.003.0005.

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Reconstructing real-world system dynamics from time series data on a single variable is challenging because real-world data often exhibit a highly volatile and irregular appearance potentially driven by several diverse factors. NLTS methods help eliminate less likely drivers of dynamic irregularity. We set a benchmark for regular behavior by investigating how linear systems of ODEs are restricted to exponential and periodic dynamics, and illustrating how irregular behavior can arise if regular linear dynamics are corrupted with noise or shift over time (i.e., nonstationarity). We investigate how data can be pre-processed to control for the noise and nonstationarity potentially camouflaging nonlinear deterministic drivers of observed complexity. We can apply signal-detection methods, such as Singular Spectrum Analysis (SSA), to separate signal from noise in the data, and test the signal for nonstationarity potentially corrected with SSA. SSA measures signal strength which provides a useful initial indicator of whether we should continue searching for endogenous nonlinear drivers of complexity. We begin diagnosing deterministic structure in an isolated signal by attempting to reconstructed a shadow attractor. Finally, we use the classic Lorenz equations to illustrate how a deterministic nonlinear system of ODEs with at least three equations can generate observed irregular dynamics endogenously without aid of exogenous shocks or nonstationary dynamics.
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10

(Editor), Michael E. Burczynski, und John C. Rockett (Editor), Hrsg. Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches. CRC, 2005.

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11

E, Burczynski Michael, und Rockett John C, Hrsg. Surrogate tissue analysis: Genomic, proteomic and metabolomic approaches. Boca Raton: Taylor & Francis, 2005.

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12

Surrogate tissue analysis: Genomic, proteomic, and metabolomic approaches. Boca Raton, FL: CRC/Taylor & Francis, 2004.

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13

Burczynski, Michael E., und John C. Rockett. Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches. Taylor & Francis Group, 2005.

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14

Burczynski, Michael E., und John C. Rockett. Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches. Taylor & Francis Group, 2005.

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15

Burczynski, Michael E., und John C. Rockett. Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches. Taylor & Francis Group, 2010.

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16

Warwick, David. Prevention of thrombosis in orthopaedic surgery. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.0006.

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♦ The risk–benefit of thromboprophylaxis in orthopaedic surgery remains unclear♦ Some conditions, such as major trauma, carry a much higher risk than others, such as routine knee replacement♦ Some patients appear to be genetically more predisposed than others♦ In trials of efficacy of thromboembolism, the use of deep vein thrombosis as a surrogate endpoint for death from a pulmonary embolus may not be completely reliable♦ There is a variety of mechanical and chemical methods available, each of which has real and potential advantages as well as real and potential dangers♦ Even the length of time that a patient is at risk after major surgery is unclear♦ Clinicians should adhere to guidelines where possible.
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17

Hall, Peter. Principal component analysis for functional data. Herausgegeben von Frédéric Ferraty und Yves Romain. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780199568444.013.8.

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This article discusses the methodology and theory of principal component analysis (PCA) for functional data. It first provides an overview of PCA in the context of finite-dimensional data and infinite-dimensional data, focusing on functional linear regression, before considering the applications of PCA for functional data analysis, principally in cases of dimension reduction. It then describes adaptive methods for prediction and weighted least squares in functional linear regression. It also examines the role of principal components in the assessment of density for functional data, showing how principal component functions are linked to the amount of probability mass contained in a small ball around a given, fixed function, and how this property can be used to define a simple, easily estimable density surrogate. The article concludes by explaining the use of PCA for estimating log-density.
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18

Haimes, Y. Y., W. A. Hall und H. T. Freedman. Multiobjective Optimization in Water Resources Systems: The Surrogate Worth Trade-Off Method. Elsevier Science & Technology Books, 2011.

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19

Parmelee, John. Meet the Candidate Videos. Greenwood Publishing Group, Inc., 2003. http://dx.doi.org/10.5040/9798400684548.

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Parmelee shows how presidential primary campaign videocassettes serve many functions for candidates on their road to the White House. These videocassettes, which include images and issues often based on polling data and focus groups, are sent out before the primaries to battleground states to establish an initial image of the candidate. A variety of methods are used to explore the videocassettes of the Democratic and Republican presidential candidates—Gary Bauer, Bill Bradley, George W. Bush, Steve Forbes, Al Gore, and John McCain—who released presidential primary meet the candidate videos during the 2000 race. Frame analysis, quantitative content analysis, and in-depth interviews with the producers of these videos were employed to provide answers to Parmelee's main research question: What function do candidate videos serve in presidential primary campaigns? Findings indicate that these videos, which can run from 5 to 20 minutes in length, serve a clear educational function to explain the candidates' stand on key policy issues. The videos—which are mailed to voters, journalists, and potential doners, and shown to Democratic and GOP faithful at party functions—also serve as fundraisers, surrogate speakers, and inoculators. But, while the videos share some common functions, each campaign targets its video to a slightly different audience based on the campaign's overall strategy. Of particular interest to scholars, students, and other researchers involved with American presidential politics and political communications.
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20

Voigt, Marc Alexander. Abstammungsrecht 2. 0: Ein Rechtsvergleichender Reformvorschlag Vor Dem Hintergrund der Methoden der Kuenstlichen Befruchtung. Lang GmbH, Internationaler Verlag der Wissenschaften, Peter, 2015.

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21

Voigt, Marc Alexander. Abstammungsrecht 2. 0: Ein Rechtsvergleichender Reformvorschlag Vor Dem Hintergrund der Methoden der Kuenstlichen Befruchtung. Lang GmbH, Internationaler Verlag der Wissenschaften, Peter, 2015.

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22

Voigt, Marc Alexander. Abstammungsrecht 2. 0: Ein Rechtsvergleichender Reformvorschlag Vor Dem Hintergrund der Methoden der Kuenstlichen Befruchtung. Lang GmbH, Internationaler Verlag der Wissenschaften, Peter, 2015.

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23

Voigt, Marc Alexander. Abstammungsrecht 2. 0: Ein Rechtsvergleichender Reformvorschlag Vor Dem Hintergrund der Methoden der Kuenstlichen Befruchtung. Lang GmbH, Internationaler Verlag der Wissenschaften, Peter, 2015.

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24

Evaluation of Data Needs, Crash Surrogates, and Analysis Methods to Address Lane Departure Research Questions Using Naturalistic Driving Study Data. Washington, D.C.: Transportation Research Board, 2011. http://dx.doi.org/10.17226/22848.

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25

Narouze, Samer N. Cervical Sympathetic Block: Fluoroscopy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0027.

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In those patients with significant sympathetically maintained pain, repeated blocks may provide a therapeutic value and help facilitate physical therapy and rehabilitation. Cervical sympathetic blocks have been traditionally performed by using surface landmarks, however imaging-guided blocks are strongly recommended to avoid potential serious complications. Most preganglionic sympathetic efferents innervating the head, neck, and upper extremity either pass through or synapse at the stellate ganglion. This provides an ideal target for blockade of sympathetic innervation to the head, neck, and upper limbs. The stellate ganglion block can be performed at the C6 and C7 transverse processes. Fluoroscopy is a reliable method for identifying bony surfaces, which facilitates identifying the C6 and C7 transverse processes; however, this is only a surrogate marker, because the location of the cervical sympathetic trunk is defined by the fascial plane of the prevertebral fascia, which cannot be visualized with fluoroscopy.
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26

Staitieh, Bashar S., und Greg S. Martin. Therapeutic goals of fluid resuscitation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0070.

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Optimizing tissue perfusion by administering intravenous fluids presents a special challenge to the intensive care unit (ICU) clinician. Recent studies have drastically altered how we assess a patient’s fluid responsiveness, particularly with regard to upstream surrogates of tissue perfusion. Central venous pressure and pulmonary capillary wedge pressure have been found to be inaccurate markers of fluid responsiveness and have given way to methods such as cardiac output as assessed by echocardiography and the various forms of arterial waveform analysis. These newer techniques, such as stroke volume variation, systolic pressure variation, and pulse pressure variation, have been found to better delineate which patients will respond to a fluid challenge with an increase in cardiac output, and which will not. In addition, traditional methods of assessing the consequences of excessive fluid administration, such as pulmonary oedema and the non-anion gap acidosis of saline administration, have given way to more sophisticated measurements of extravascular lung water, now available at the bedside. Downstream markers of tissue perfusion, such as base deficit, central venous oxygen saturations, and lactic acid, continue to be useful in particular clinical settings, but are all relatively non-specific markers, and are therefore difficult to use as resuscitation targets for ICU patients in general. Finally, recent data on septic shock and ARDS have demonstrated the importance of conservative fluid strategies, while data in surgical populations have emphasized the need for judicious fluid administration and attention to the balance of blood products used in resuscitation efforts.
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27

Cain, Andrew. Jerome's Commentaries on the Pauline Epistles and the Architecture of Exegetical Authority. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192847195.001.0001.

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In the late fourth and early fifth centuries, during a fifty-year stretch sometimes dubbed a Pauline “renaissance” of the western church, six different authors produced over four dozen commentaries in Latin on Paul’s epistles. Among them was Jerome, who commented on four epistles (Galatians, Ephesians, Titus, Philemon) in 386 after recently having relocated to Bethlehem from Rome. His commentaries occupy a time-honored place in the centuries-long tradition of Latin-language commenting on Paul’s writings. They also constitute his first foray into the systematic exposition of whole biblical books (and his only experiment with Pauline interpretation on this scale), and so they provide precious insight into his intellectual development at a critical stage of his early career before he would go on to become the most prolific biblical scholar of Late Antiquity. This monograph provides the first book-length treatment of Jerome’s opus Paulinum in any language. Adopting a cross-disciplinary approach, Cain comprehensively analyzes the commentaries’ most salient aspects—from the inner workings of Jerome’s philological method and engagement with his Greek exegetical sources, to his recruitment of Paul as an anachronistic surrogate for his own theological and ascetic special interests. One of the overarching concerns of this book is to explore and to answer, from multiple vantage points, a question that was absolutely fundamental to Jerome in his fourth-century context: what are the sophisticated mechanisms by which he legitimized himself as a Pauline commentator, not only on his own terms but also vis-à-vis contemporary western commentators?
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