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Thematische Bibliographien / Streptozotocin model

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Auswahl der wissenschaftlichen Literatur zum Thema „Streptozotocin model“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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Zeitschriftenartikel zum Thema "Streptozotocin model"

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Hady, Keita. "LIPOPEROXIDATION AND VASCULAR REACTIVITY RESPONSE IN RAT MODELS OF STREPTOZOTOCININDUCED DIABETES MELLITUS." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1102–9. https://doi.org/10.5281/zenodo.163852.

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The murine model of streptozotocin-induced diabetes mellitus has been widely used for many authors. However, there are meaningful discrepancies about the functional alterations reported; especially regarding vascular response. Objective: The objective of the present study was to examine how the prolonged effects of diabetes mellitus induced by administering streptozotocin affects vascular reactivity, lipoperoxidation and endothelial function in aortic rings and if the administration of nicotinamide will partially protect those adverse outcomes. Performing parallel studies could contribute in p

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Miao, Ming San, Bo Lin Cheng, and Na Jiang. "Effect of Sophora Japonica Total Flavonoids on Mouse Models of Hyperglycemia and Diabetes Model." Applied Mechanics and Materials 664 (October 2014): 397–401. http://dx.doi.org/10.4028/www.scientific.net/amm.664.397.

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Objective: To investigate the effects of Sophora japonica total flavonoids hyperglycemia and diabetes in mice models. Methods: intraperitoneal injection of epinephrine, intravenous injection of freshly prepared alloxan or intravenous injection of streptozotocin, alloxan build adrenaline or hyperglycemia model streptozotocin diabetic model. Glucose values were selected for each experiment> 11.1mmol / L, with a significantly more drinking, eating, and more urinary symptoms in mice 60, according to blood glucose levels were randomly divided into six groups, namely large, medium and small dos

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Skaletskaya, G. N., N. N. Skaletskiy, E. A. Volkova, and V. I. Sevastyanov. "Streptozotocin model of stable diabetes mellitus." Russian Journal of Transplantology and Artificial Organs 20, no. 4 (2019): 83–88. http://dx.doi.org/10.15825/1995-1191-2018-4-83-88.

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Aim:to create a model of stable experimental diabetes mellitus (DM) in laboratory rats using streptozotocin (STZ).Materials and methods.The dynamics of changes in glycemia and survival in 60 Wistar rats was determined. STZ at a dosage of 70 mg/kg was administered to these rats in two ways: once and fractionally (within 5 days).Results.After a single injection of the STZ, 6 out of 30 rats (20%) died, in 7 cases (23.3%) a spontaneous reversion of the diabetic status occurred and in 17 animals (56.6%) the DM remained stable throughout the observation period (8 weeks). After the fractional adminis

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Pratiwi, Egi Claudia, Elsa Trinovita, and Agnes Immanuela Toemon. "Literatur Review: Hubungan Model Hewan Coba (Faktor Jenis Kelamin dan Hormon) pada Sensitivitas Induksi Streptozotocin sebagai Agen Diabetogenik." Jurnal Surya Medika 7, no. 2 (2022): 132–41. http://dx.doi.org/10.33084/jsm.v7i2.2646.

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Diabetes mellitus (DM) is a metabolic disease that global concern and characterized by hyperglycemia. Tests for antidiabetic agents, either discovering new drugs or antidiabetic components, have been developed using experimental animals induced with the diabetogenic agent streptozotocin. The side effects of streptozotocin were reported lower than alloxan. The sensitivity of streptozotocin induction can be relied on by several factors such as sex and hormones—the difference in results in several studies regarding the relationship between streptozotocin induction sensitivity with gender. The res

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Rahman, Nurdin, I. Made Tangkas, Sri Muliyani Sabang, Bohari Bohari, and Rukman Abdullah. "The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 849–53. http://dx.doi.org/10.3889/oamjms.2021.7065.

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Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% suc

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Fajarwati, Indah, Dedy Duryadi Solihin, Tutik Wresdiyati, and Irmanida Batubara. "Administration of alloxan and streptozotocin in Sprague Dawley rats and the challenges in producing diabetes model." IOP Conference Series: Earth and Environmental Science 1174, no. 1 (2023): 012035. http://dx.doi.org/10.1088/1755-1315/1174/1/012035.

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Abstract Alloxan and streptozotocin are the most prominent diabetogenic agents in diabetes research. However, most published reports do not represent the practical importance of their application. The present study evaluated alloxan and streptozotocin with various doses to determine the optimal diabetic model in Sprague Dawley rats. This study also identified the challenges in inducing diabetes using both agents. Every dose of alloxan (120, 150, 180 mg/kg) and streptozotocin (40, 50, 60 mg/kg) was administered through intraperitoneal injection. The results showed that alloxan-induced rats prod

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Malaisse, Willy J., Marie-Hélène Giroix, Dagmar Zähner, Greta Marynissen, Abdullah Sener, and Bernard Portha. "Neonatal streptozotocin injection: A model of glucotoxicity?" Metabolism 40, no. 10 (1991): 1101–5. http://dx.doi.org/10.1016/0026-0495(91)90137-l.

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Mahata, Liganda Endo, Hirowati Ali, and Arina Widya Murni. "Effect of Streptozotocin on Liver Histology Damage in Rats Model of Gestational Diabetes Mellitus." International Journal of Research and Review 8, no. 9 (2021): 18–22. http://dx.doi.org/10.52403/ijrr.20210904.

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Background: Gestational Diabetes Mellitus (GDM) is a disorder of carbohydrate metabolism that causes hyperglycemia, insulin resistance and failure of organs especially the liver. There is great interest in understanding the pathophysiology and treatment of GDM. Due to ethical issues involving human studies, it is necessary to use animal models to understand pathophysiology and potential treatment for GDM. Streptozotocin-induced diabetes mellitus in pregnant rats was commonly used by several author. Aims: The aim of this study is to investigate the effect of streptozotocin (STZ) on liver histol

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Vastyanov, R. S., and O. V. Chekhlova. "Pathophysiological model of indirect revascularization in rats with microangiopathy of limbs caused by experimental streptozocin diabetes." Reports of Morphology 25, no. 4 (2019): 24–29. http://dx.doi.org/10.31393/morphology-journal-2019-25(4)-04.

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Despite the large number of publications, the model of experimental diabetes after the introduction of streptozotocin remains a subject of lively scientific debate. The purpose of this study was to develop a pathophysiological model of indirect revascularization in rats with microangiopathy of limbs caused by experimental streptozotocin diabetes. Experimental studies were carried out in a chronic experiment on 100 sexually mature Wistar rats weighing 180-250 g. The streptozotocin diabetes model used. After culling animals from increased resistance to pancreatotropic toxicity by the criterion o

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Ermakova, P. S., L. A. Lugovaya, E. A. Vasilchikova, et al. "Model of the formation of streptozotocin-induced diabetes in Wiesenau pigs with assessment of its effectiveness and stability." Diabetes mellitus 28, no. 2 (2025): 111–23. https://doi.org/10.14341/dm13168.

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BACKGROUND: Research aimed at creating and validating models of diabetes plays an important role in the development of new treatments for this disease. Large animal models may bridge the gap between basic research and clinical trials of new technologies for the treatment of insulin deficiency. At the moment, the most popular model is streptozotocin-induced diabetes. However, different species and breeds of animals respond differently to streptozotocin. Thus, although models already exist in different breeds of pigs, verification of the Wiesenau pig model of streptozotocin-induced diabetes is a

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Dissertationen zum Thema "Streptozotocin model"

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Грицюк, Мар'яна Іванівна, and Діана Ігорівна Навчук. "Streptozotocin model of diabetes mellitus." Thesis, Хист. Всеукраїнський медичний журнал молодих вчених. - Чернівці: БДМУ, Чернівці 2014, випуск 16., 2014, 2014. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/8659.

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Shamsaldeen, Yousif. "Endothelial TRPV4 dysfunction in a streptozotocin-diabetic Rat Model." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17622.

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Diabetes mellitus is a complex disease characterised by chronic hyperglycaemia due to compromised insulin synthesis and secretion, or decreased tissue sensitivity to insulin, if not all three conditions. Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasodilation is impaired. The aim of this study was to examine the involvement of TRPV4 in diabetes endothelial dysfunction. Male Charles River Wistar rats (350-450 g) were injected with 65mg/kg streptozotocin (STZ) intraperitoneally. STZ-injected rats were compared with naïve rats (not injected with S

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Bahremand, Saeid. "Blood Glucose Management Streptozotocin-Induced Diabetic Rats by Artificial Neural Network Based Model Predictive Control." Thesis, Southern Illinois University at Edwardsville, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10249804.

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<p> Diabetes is a group of metabolic diseases where the body’s pancreas does not produce enough insulin or does not properly respond to insulin produced, resulting in high blood sugar levels over a prolonged period. There are several different types of diabetes, but the most common forms are type 1 and type 2 diabetes. Type 1 diabetes Mellitus (T1DM) can occur at any age, but is most commonly diagnosed from infancy to late 30s. If a person is diagnosed with type 1 diabetes, their pancreas produces little to no insulin, and the body’s immune system destroys the insulin-producing cel

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Kekatpure, Avantika. "Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase." Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/737.

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Objectives: To date little is known of the interaction between diabetes and sex hormones in the vasculature. A number of studies suggest that premenopausal diabetic women loose their gender based cardiovascular protection. However, there is insufficient evidence to explain the mechanism underlying the loss of this gender based cardioprotection in premenopausal diabetic women. The objectives of this study were to investigate whether there is a gender difference in the aortic endothelial function in · streptozotocin (STZ, 58 mg/kg, iv)-induced diabetic rats, and the potential role of superoxide

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Thomas, Adam J. "Characterization of cAMP-Specific Phosphodiesterase-4 (R)-[11C]Rolipram Small Animal Positron Emission Tomography and Application in a Streptozotocin-Induced Model of Hyperglycemia." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19877.

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Elevated sympathetic nervous system (SNS) tone contributes to excess cardiac mortality associated with type 2 diabetes mellitus (T2DM). Chronic SNS stimulation has detrimental effects to the heart, in particular, with its cell signaling abilities. (R)-[11C]Rolipram small animal positron emission tomography (PET), an noninvasive nuclear imaging modality, was used to assess phosphodiesterase-4 (PDE4) alterations in a high fat diet (HFD), streptozotocin (STZ) induced model of hyperglycemia in rats. Prior to investigation in the animal model, characterization of (R)-[11C]rolipram small animal PET

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Ayeleso, Ademola Olabode. "Influence of two plant products (red palm oil and rooibos) on streptozotocin-induced hyperglycaemia and its implications on antioxidant status and other biochemical parameters in an animal model." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/1517.

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Thesis submitted in fulfilment of the requirements for the Doctor of Technology: Biomedical Technology In the Faculty of Health and Wellness At the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY, 2012<br>Diabetes mellitus is a major health problem not only in urban, but also in the rural areas and is diagnosed by the presence of high glucose levels in the blood. Oxidative stress is known to be actively involved in the onset and progression of diabetes and its complications. Antioxidants have important roles in biological systems by scavenging free radicals which may result in oxidative damage of biol

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Sakai, Takeru. "Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet." Kyoto University, 2015. http://hdl.handle.net/2433/195969.

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Kusakabe, Toru. "Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet." Kyoto University, 2009. http://hdl.handle.net/2433/124316.

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Haley, James M. "Ex Vivo Evaluation of Myocardial Beta-Adrenergic Receptors in High-Fat Fed STZ and ZDF Models of Diabetes Using [3H]-CGP12177." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30363.

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Diabetes mellitus (DM) and hyperglycemia contribute to sympathetic nervous system (SNS) activation and cardiovascular dysfunction. SNS activation and increased norepinephrine levels downregulate cardiac β-adrenergic receptors (β-AR). The ADMIRE-HF trial identified reduced cardiac SNS innervation as an independent prognostic marker in heart failure. The β-AR antagonist [3H]-CGP12177 was used to quantify cardiac β-AR in ex vivo biodistribution studies in streptozotocin (STZ)-treated rats after 8 weeks of sustained hyperglycemia, and in the Zucker Diabetic Fatty (ZDF) rat model of type-2 diabetes

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Wong, Ching-keung, and 黃靜強. "The effects of streptozotocin-diabetes on adrenomedullin gene expression and peptide levels in the gastrointestinal system of therat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45011503.

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Bücher zum Thema "Streptozotocin model"

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Klinkhammer, Christiane. Untersuchungen zum Mechanismus der immunologischen Reaktionen im Niedrigdosis-Streptozotocin-Modell der Maus: T-zellspezifische Reaktionen gegen Streptozotocin. 1987.

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Hibbe, Thomas. Immuntherapeutische Effekte von gamma-Interferon, Interleukin-2, Lipopolysacchariden, Cyclophosphamid und Thiamazol im Niedrigdosis-Streptozotocin-Modell und in der NOD-Maus. 1988.

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Runck, Manfred. Auswirkungen der Cyclosporin-A-Vorbehandlung beim Streptozotozin-induzierten Diabetes-Modell (Like/Rossini) der Maus: Eine quantitative Untersuchung der Langerhans'schen Inseln. 1989.

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Reinecke, Friedrich Alexander. Das renale Kallikrein-Kinn-System bei diabetischer Nephropathie und seine Beeinflussung durch den ACE-Hemmer Ramipril am Modell des Streptozotocin-induzierten Diabetes Mellitus der Ratte. 2003.

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Buchteile zum Thema "Streptozotocin model"

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Müller, Dorothea, Konstanze Plaschke, and Siegfried Hoyer. "Intracerebroventricular Injection of Streptozotocin — An Animal Model for Sporadic Alzheimer’s Disease?" In Alzheimer’s and Parkinson’s Diseases. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4757-9145-7_58.

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Motiño, Omar, Sijing Li, Flavia Lambertucci, et al. "A Mouse Model of Hepatocellular Carcinoma Induced by Streptozotocin and High-Fat Diet." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3694-7_5.

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Labak, M., T. Foniok, D. Kirk, et al. "Metabolic Changes in Rat Brain Following Intracerebroventricular Injections of Streptozotocin: A Model of Sporadic Alzheimer’s Disease." In Brain Edema XIV. Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-98811-4_32.

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Rungger-Brändle, Elisabeth, and André A. Dosso. "Streptozotocin-Induced Diabetes — A Rat Model to Study Involvement of Retinal Cell Types in the Onset of Diabetic Retinopathy." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0067-4_25.

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King, Aileen J. F., Elisabet Estil·les, and Eduard Montanya. "Use of Streptozotocin in Rodent Models of Islet Transplantation." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0385-7_10.

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Meister, R., and K. Paul. "Investigations of Glucose Tolerance Following Pancreatic Transplantation in Rats with Streptozotocin-Induced Diabetes." In Microsurgical Models in Rats for Transplantation Research. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-61657-0_31.

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Rodrigues Letícia, Biasibetti Regina, Swarowsky Alessandra, et al. "Hippocampal Alterations in Rats Submitted to Streptozotocin-Induced Dementia Model: Neuroprotection with Aminoguanidine." In Advances in Alzheimer’s Disease. IOS Press, 2011. https://doi.org/10.3233/978-1-60750-733-8-215.

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Although the exact cause of Alzheimer's disease remains elusive, many possible risk factors and pathological alterations have been used in the elaboration of in vitro and in vivo models of this disease in rodents, including intracerebral (ICV) infusion of streptozotocin (STZ). Using this model, we evaluated spatial cognitive deficit and neurochemical hippocampal alterations, particularly astroglial protein markers such as glial fibrillary acidic protein (GFAP) and S100B, glutathione content, NO production and cerebrospinal fluid (CSF) S100B; in addition, prevention of these alterations by amin

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Kelliny, Sally, Isaac Deng, Xin-Fu Zhou, and Larisa Bobrovskaya. "Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice." In Handbook of Animal Models in Neurological Disorders. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-89833-1.00026-4.

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Kawaharada, Ritsuko, and Akio Nakamura. "Future Risks for Children Born to Mothers with Gestational Diabetes: Elucidation Using the Cell Model Approach." In Gestational Diabetes Mellitus - New Developments [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100117.

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A number of studies have shown that foetal nutritional status significantly impacts an unborn child’s long-term health. The developmental origins of health and disease (DOHaD) hypothesis proposes that if a child is undernourished in the foetal period, the child will develop diabetes and hypertension in the future if adequate nutrition is given after birth. Moreover, hyperglycaemia (e.g. gestational diabetes mellitus [GDM]) experienced during foetal life can reportedly cause various complications in children. As diabetes is increasing worldwide, so is GDM, and many studies have been conducted u

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"Intracerebroventricular-Streptozotocin Induced Insulin Resistant In Vivo Model of Sporadic Alzheimer's Disease: Pathophysiological Aspects and Potential Therapeutic Targets." In Animal Models for Neurological Disorders, edited by Ansab Akhtar and Sangeeta Pilkhwal Sah. BENTHAM SCIENCE PUBLISHERS, 2021. http://dx.doi.org/10.2174/9789815039689121010013.

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Konferenzberichte zum Thema "Streptozotocin model"

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Hendrawan, Thressia, Nurul Paramita, Dewi Irawati, and Ani Retno Prijanti. "Diabetes Sprague-Dawley Model Induced With Fat Diet And Streptozotocin." In Surabaya International Physiology Seminar. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007337902920293.

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Yuan, Hongping, Dongxu Zhao, and Boyin Zhang. "Minocycline Attenuates Kidney Injury in a Rat Model Of Streptozotocin-Induced Diabetic Nephropathy." In International Conference on Biomedical and Biological Engineering. Atlantis Press, 2016. http://dx.doi.org/10.2991/bbe-16.2016.41.

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Johnson, Kennita A., A. Gloria Nyankima, Paul A. Dayton, and Emily Chang. "Characterizing volumes of kidney segments in Streptozotocin induced diabetic rat model utilizing 4D contrast-enhanced ultrasound." In 2016 IEEE International Ultrasonics Symposium (IUS). IEEE, 2016. http://dx.doi.org/10.1109/ultsym.2016.7728850.

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Zangerolamo, Lucas, Helena Sampaio, Gabriela Soares, et al. "The bile acid TUDCA reduces hypothalamic inflammation and food intake in streptozotocin-induced Alzheimer’s mice model." In Congresso de Iniciação Científica UNICAMP. Universidade Estadual de Campinas, 2019. http://dx.doi.org/10.20396/revpibic2720192769.

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Indrayoni, Putu, I. Ananta, and Anak Padmiswari. "Model Aren Vinegar (Arenga pinnata Merr.) Phytochemical Analysis and Hypoglycemic Effects in Streptozotocin-Niacinamide-Induced Rats." In The Bali Biennial International Conference on Health Sciences. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0011939200003576.

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Anapali, Merve. "Resveratrol and Vitamin D ameliorate liver fibrosis and apoptosis in fructose-fed diet and streptozotocin induced T2DM model." In European Microscopy Congress 2020. Royal Microscopical Society, 2021. http://dx.doi.org/10.22443/rms.emc2020.1144.

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Hashimova, Ulduz, Leyla Gadirova, and Venera Khairova. "STUDY OF THE ACTIVITY OF SOME GLUTAMATE ENZYMES IN THE BRAIN USING THE MODEL OF STREPTOZOTOCIN-INDUCED NEURODEGENERATION." In XVIII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2022. http://dx.doi.org/10.29003/m2716.sudak.ns2022-18/97.

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Kerrigan, L., K. Edgar, A. Russell-Hallinan, D. Grieve, and C. Watson. "26 Using combination of high-fat diet and high-dose streptozotocin to develop an in vivo model of diabetic cardiomyopathy." In Irish Cardiac Society Annual Scientific Meeting & AGM, Thursday October 17th – Saturday October 19th 2019, Galway, Ireland. BMJ Publishing Group Ltd and British Cardiovascular Society, 2019. http://dx.doi.org/10.1136/heartjnl-2019-ics.26.

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Akarca Dizakar, Saadet Özen. "The effects of sunitinib on immunoreactivities of vimentin, E-cadherin and S100 in kidneys of the experimental Streptozotocin -induced mouse model." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-235.

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Michel, Martin, Aqsa Ashfaq, Myriam Meineck, Julia Weinmann-Menke, Ebru Arioglu-Inan, and Andrea Pautz. "No Evidence for Beneficial Empagliflozin Effects in the Kidney of Female Rats in a Streptozotocin-induced Model of Type 1 Diabetes." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.003.933440.

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Berichte der Organisationen zum Thema "Streptozotocin model"

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Cook, Alonzo D. Realistic Murine Model for Streptozotocin-induced Diabetic Peripheral Neuropathy. Science Repository OÜ, 2018. http://dx.doi.org/10.31487/j.rgm.2018.02.006.

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