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1
Yoseph Y. F, Deograsias. „Analisis Minat Beli Toko Kelontong Di Kecamatan Wonokromo, Surabaya Dengan Pendekatan Store Atmosphere“. BIP's : JURNAL BISNIS PERSPEKTIF 11, Nr. 2 (17.01.2020): 144–53. http://dx.doi.org/10.37477/bip.v11i2.138.
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The grocery store industry is still facing a form of economic business that hasgood prospects, even in a crisis. However, in the same period many took thegrocery that went bankrupt, because they were no longer able to maintain sales.There needs to be a fundamental change in the grocery store in order, but thegrocery store is starting to rise from behind. As Indonesian people, are we ready to help by diverting shopping at grocery stores. By agreeing to Store Atmosphere,it is expected that willingness to buy from grocery stores will increase.
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Yoseph Y. F., Deograsias. „Analisis Minat Beli Toko Kelontong Di Kecamatan Wonokromo, Surabaya Dengan Pendekatan Store Atmosphere“. BIP's JURNAL BISNIS PERSPEKTIF 11, Nr. 2 (31.07.2019): 144–53. http://dx.doi.org/10.37477/bip.v11i2.20.
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The grocery store industry is still facing a form of economic business that hasgood prospects, even in a crisis. However, in the same period many took thegrocery that went bankrupt, because they were no longer able to maintain sales.There needs to be a fundamental change in the grocery store in order, but thegrocery store is starting to rise from behind. As Indonesian people, are we ready to help by diverting shopping at grocery stores. By agreeing to Store Atmosphere,it is expected that willingness to buy from grocery stores will increase.
3
Weidema, A. Frederik, S. Jeffrey Dixon und Stephen M. Sims. „Activation of P2Y but not P2X4 nucleotide receptors causes elevation of [Ca2+]i in mammalian osteoclasts“. American Journal of Physiology-Cell Physiology 280, Nr. 6 (01.06.2001): C1531—C1539. http://dx.doi.org/10.1152/ajpcell.2001.280.6.c1531.
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Extracellular nucleotides cause elevation of cytosolic free Ca2+ concentration ([Ca2+]i) in osteoclasts, although the sources of Ca2+ are uncertain. Activation of P2Y receptors causes Ca2+ release from stores, whereas P2X receptors are ligand-gated channels that mediate Ca2+ influx in some cell types. To examine the sources of Ca2+, we studied osteoclasts from rat and rabbit using fura 2 fluorescence and patch clamp. Nucleotide-induced rise of [Ca2+]ipersisted on removal of extracellular Ca2+(Ca[Formula: see text]), indicating involvement of stores. Inhibition of phospholipase C (PLC) with U-73122 or inhibition of endoplasmic reticulum Ca2+-ATPase with cyclopiazonic acid or thapsigargin abolished the rise of [Ca2+]i. After store depletion in the absence of Ca[Formula: see text], addition of Ca[Formula: see text] led to a rise of [Ca2+]i consistent with store-operated Ca2+ influx. Store-operated Ca2+ influx was greater at negative potentials and was blocked by La3+. In patch-clamp studies where PLC was blocked, ATP induced inward current indicating activation of P2X4 nucleotide receptors, but with no rise of [Ca2+]i. We conclude that nucleotide-induced elevation of [Ca2+]i in osteoclasts arises primarily through activation of P2Y nucleotide receptors, leading to release of Ca2+ from intracellular stores.
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Golovina, Vera A., Oleksandr Platoshyn, Colleen L. Bailey, Jian Wang, Alisa Limsuwan, Michele Sweeney, Lewis J. Rubin und Jason X. J. Yuan. „Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation“. American Journal of Physiology-Heart and Circulatory Physiology 280, Nr. 2 (01.02.2001): H746—H755. http://dx.doi.org/10.1152/ajpheart.2001.280.2.h746.
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A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) due to Ca2+ release from intracellular Ca2+ stores and Ca2+ influx through plasmalemmal Ca2+ channels plays a critical role in mitogen-mediated cell growth. Depletion of intracellular Ca2+ stores triggers capacitative Ca2+ entry (CCE), a mechanism involved in maintaining Ca2+ influx and refilling intracellular Ca2+ stores. Transient receptor potential ( TRP) genes have been demonstrated to encode the store-operated Ca2+ channels that are activated by Ca2+ store depletion. In this study, we examined whether CCE, activity of store-operated Ca2+ channels, and human TRP1 ( hTRP1) expression are essential in human pulmonary arterial smooth muscle cell (PASMC) proliferation. Chelation of extracellular Ca2+ and depletion of intracellularly stored Ca2+ inhibited PASMC growth in media containing serum and growth factors. Resting [Ca2+]cyt as well as the increases in [Ca2+]cyt due to Ca2+ release and CCE were all significantly greater in proliferating PASMC than in growth-arrested cells. Consistently, whole cell inward currents activated by depletion of intracellular Ca2+ stores and the mRNA level of hTRP1 were much greater in proliferating PASMC than in growth-arrested cells. These results suggest that elevated [Ca2+]cyt and intracellularly stored [Ca2+] play an important role in pulmonary vascular smooth muscle cell growth. CCE, potentially via hTRP1-encoded Ca2+-permeable channels, may be an important mechanism required to maintain the elevated [Ca2+]cyt and stored [Ca2+] in human PASMC during proliferation.
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McDaniel, Sharon S., Oleksandr Platoshyn, Jian Wang, Ying Yu, Michele Sweeney, Stefanie Krick, Lewis J. Rubin und Jason X. J. Yuan. „Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction“. American Journal of Physiology-Lung Cellular and Molecular Physiology 280, Nr. 5 (01.05.2001): L870—L880. http://dx.doi.org/10.1152/ajplung.2001.280.5.l870.
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Agonist-induced increases in cytosolic Ca2+ concentration ([Ca2+]cyt) in pulmonary artery (PA) smooth muscle cells (SMCs) consist of a transient Ca2+ release from intracellular stores followed by a sustained Ca2+ influx. Depletion of intracellular Ca2+ stores triggers capacitative Ca2+ entry (CCE), which contributes to the sustained increase in [Ca2+]cyt and the refilling of Ca2+ into the stores. In isolated PAs superfused with Ca2+-free solution, phenylephrine induced a transient contraction, apparently by a rise in [Ca2+]cyt due to Ca2+ release from the intracellular stores. The transient contraction lasted for 3–4 min until the Ca2+ store was depleted. Restoration of extracellular Ca2+ in the presence of phentolamine produced a contraction potentially due to a rise in [Ca2+]cyt via CCE. The store-operated Ca2+ channel blocker Ni2+ reduced the store depletion-activated Ca2+ currents, decreased CCE, and inhibited the CCE-mediated contraction. In single PASMCs, we identified, using RT-PCR, five transient receptor potential gene transcripts. These results suggest that CCE, potentially through transient receptor potential-encoded Ca2+ channels, plays an important role in agonist-mediated PA contraction.
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Ng, Lih Chyuan, Barry D. Kyle, Alison R. Lennox, Xiao-Ming Shen, William J. Hatton und Joseph R. Hume. „Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells“. American Journal of Physiology-Cell Physiology 294, Nr. 1 (Januar 2008): C313—C323. http://dx.doi.org/10.1152/ajpcell.00258.2007.
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Previous studies have shown that, in acutely dispersed canine pulmonary artery smooth muscle cells (PASMCs), depletion of both functionally independent inositol 1,4,5-trisphosphate (IP3)- and ryanodine-sensitive Ca2+ stores activates capacitative Ca2+ entry (CCE). The present study aimed to determine if cell culture modifies intracellular Ca2+ stores and alters Ca2+ entry pathways caused by store depletion and hypoxia in canine PASMCs. Intracellular Ca2+ concentration ([Ca2+]i) was measured in fura 2-loaded cells. Mn2+ quench of fura 2 signal was performed to study divalent cation entry, and the effects of hypoxia were examined under oxygen tension of 15–18 mmHg. In acutely isolated PASMCs, depletion of IP3-sensitive Ca2+ stores with cyclopiazonic acid (CPA) did not affect initial caffeine-induced intracellular Ca2+ transients but abolished 5-HT-induced Ca2+ transients. In contrast, CPA significantly reduced caffeine- and 5-HT-induced Ca2+ transients in cultured PASMCs. In cultured PASMCs, store depletion or hypoxia caused a transient followed by a sustained rise in [Ca2+]i. The transient rise in [Ca2+]i was partially inhibited by nifedipine, whereas the nifedipine-insensitive transient rise in [Ca2+]i was inhibited by KB-R7943, a selective inhibitor of reverse mode Na+/Ca2+ exchanger (NCX). The nifedipine-insensitive sustained rise in [Ca2+]i was inhibited by SKF-96365, Ni2+, La3+, and Gd3+. In addition, store depletion or hypoxia increased the rate of Mn2+ quench of fura 2 fluorescence that was also inhibited by these blockers, exhibiting pharmacological properties characteristic of CCE. We conclude that cell culture of canine PASMCs reorganizes IP3 and ryanodine receptors into a common intracellular Ca2+ compartment, and depletion of this store or hypoxia activates voltage-operated Ca2+ entry, reverse mode NCX, and CCE.
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Sjaastad, M. D., R. S. Lewis und W. J. Nelson. „Mechanisms of integrin-mediated calcium signaling in MDCK cells: regulation of adhesion by IP3- and store-independent calcium influx.“ Molecular Biology of the Cell 7, Nr. 7 (Juli 1996): 1025–41. http://dx.doi.org/10.1091/mbc.7.7.1025.
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Peptides containing Arg-Gly-Asp (RGD) immobilized on beads bind to integrins and trigger biphasic, transient increases in intracellular free Ca2+ ([Ca2+]i) in Madin-Darby canine kidney epithelial cells. The [Ca2+]i increase participates in feedback regulation of integrin-mediated adhesion in these cells. We examined influx pathways and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ store release as possible sources of the [Ca2+]i rise. The RGD-induced [Ca2+]i response requires external Ca2+ (threshold approximately 150 microM), and its magnitude is proportional to extracellular calcium. RGD-induced transients were attenuated by Ca2+ channel inhibitors (Ni2+ and carboxy-amidotriazole) or by plasma membrane depolarization, indicating that Ca2+ influx contributes to the response. Loading cells with heparin reduced the size of RGD-induced [Ca2+]i transients, indicating that IP3-mediated release of Ca2+ from stores may also contribute to the RGD response. Depletion of Ca2+ stores with thapsigargin activated Ni(2+)-sensitive Ca2+ influx that might also be expected to occur after IP3-mediated depletion of stored Ca2-. However, RGD elicited a Ni(2+)-sensitive Ca2+ influx even after pretreatment with thapsigargin, indicating that Ca2+ influx is controlled by a mechanism independent of IP3-mediated store depletion. We conclude that RGD-induced [Ca2+]i transients in Madin-Darby canine kidney cells result primarily from the combination of two distinct mechanisms: 1) IP3-mediated release of intracellular stores, and 2) activation of a Ca2+ influx pathway regulated independently of IP3 and Ca2+ store release. Because Ni2+ and carboxy-amidotriazole inhibited adhesion, whereas store depletion with thapsigargin had little effect, we suggest that the Ca2+ influx mechanism is most important for feedback regulation of integrin-mediated adhesion by increased [Ca2+]i.
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Anis Farras Sina und Sigit Pramono Hadi. „Pengaruh Promosi Di Instagram Terhadap Keputusan Pembelian Konsumen Sepatu Di Masa Pandemi Covid 19“. Jurnal Publikasi Teknik Informatika 2, Nr. 3 (30.09.2023): 28–36. http://dx.doi.org/10.55606/jupti.v2i3.2219.
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The purpose of this study was to determine whether there is a promotion effect on consumer decisions to buy shoe products at Rise and Risk online stores during the Covid 19 pandemic. The background of this research is considering that this pandemic is quite detrimental to business people and promotion through social media is the main thing to determine its effect on purchasing decisions. In this study, researchers used quantitative methods, namely research methods conducted by selecting samples through the purposive sampling technique. Data collection techniques in this study also went through a process, namely the distribution of questionnaires to respondents who were the subjects of this study. Respondents in this study were Instagram followers of the online store Rise and Risk, a sample of 100 respondents was taken. The data processing used in this research is using SPSS. The results obtained indicate that promotion has an influence on consumer purchasing decisions to buy shoe products at the Rise and Risk online store. The results of this study are to contribute in the field of communication, especially business communication.
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Howard, Vicki. „“The Biggest Small-Town Store in America”: Independent Retailers and the Rise of Consumer Culture“. Enterprise and Society 9, Nr. 03 (September 2008): 457–86. http://dx.doi.org/10.1017/s1467222700007278.
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The case study of Bresee's Department Store in Oneonta, New York, suggests that small-town department stores were not necessarily fully “modern” by the early twentieth century. This article demonstrates how modern, big-store, business methods came later and documents how earlier modes of trade, such as credit and bartering, persisted into the early twentieth century, even in non-rural, northern contexts. Preliminary findings suggest that eliminating the urban bias in much historiography by including small-town retailing practices may lead to a later periodization of American consumer society.
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Pandey, Shivendra, Arpita Khare und Preshth Bhardwaj. „Antecedents to local store loyalty: influence of culture, cosmopolitanism and price“. International Journal of Retail & Distribution Management 43, Nr. 1 (12.01.2015): 5–25. http://dx.doi.org/10.1108/ijrdm-08-2013-0156.
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Purpose – Cosmopolitanism is on the rise in India and traditionally shoppers have been known to patronize local stores. There is a need therefore to see the effect of cosmopolitanism and culture in context of loyalty towards local stores. Grocery items constitute major portion of purchase from local stores, therefore, pricing was also considered as a variable affecting store loyalty. The paper aims to discuss this issue. Design/methodology/approach – The paper used conclusive approach using a structured questionnaire for survey. The sample consisted of 710 respondents. There was almost an equal representation of both genders and also of metropolitan and non-metropolitan consumers. Findings – Culture and price affected local store loyalty directly. Cosmopolitanism was not found to have direct effect on loyalty. Within cultural dimensions, masculinity emerged as the most dominating trait. Minor modifications in cultural scale and major modifications in local store loyalty and cosmopolitanism are also suggested. Research limitations/implications – The study focuses only on three factors: price, culture, and cosmopolitanism. It does not examine influence of variables like personal values, lifestyle, and personality on local store loyalty behaviour. The research did not examine relationship between nature and type of product purchase decisions and its impact on store choice. Practical implications – Local stores need not be unduly worried with the incoming of organized players. The organized players should try to be cheaper and learn some tactics of local stores like customization, etc. There is a case for allowing FDI in multi-brand retail. Originality/value – Cosmopolitanism not affecting the local store loyalty directly is the original contribution of the paper. The finding casts doubts on the growth strategy of organized retailers who are opening new stores with the thinking that cosmopolitan consumer will shop from them instead of local retailers.
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Lestari, Istikomah Indah, Aris Sudianto und Muhamad Sadali. „Penerapan Aplikasi Penjualan E-Sembako Berbasis Android Pada Toko Rafa Untuk Meningkatkan Omset Pendapatan“. Infotek : Jurnal Informatika dan Teknologi 5, Nr. 1 (31.01.2022): 1–10. http://dx.doi.org/10.29408/jit.v5i1.4381.
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The rise of based business activities electronic certainly has a big impact on people's lives, especially the trade sector as experienced by Rafa store, especially at this time the world is being hit by a disaster, namely the COVID-19 pandemic which requires people to stay at home and limit activities outside the home. This is the backgroundof the author to create an application that can facilitate the community, especially housewives in meeting their household needs. This study aims to find out how the effectiveness of based applications electronic in increasing revenue at Rafa sawing stores. The method used in this study is to make direct observations to the rafa shop and conduct interviews with shop owners. By observing the researchers can find out the condition of the store both in terms of product availability and in terms of service By conducting interviews, researchers can find out the ins and outs of the store in terms of finances, availability of goods and service conditions applied by Rafa Stores at this time. For this reason, researchers are determined to apply the concept electronic to this Rafa store by building sales system E-grocery an Android based at the Rafa Sawing store.
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Chang, H.-T., C.-S. Liu, C.-T. Chou, C.-H. Hsieh, C.-H. Chang, W.-C. Chen, S.-I. Liu et al. „Econazole induces increases in free intracellular Ca2+ concentrations in human osteosarcoma cells“. Human & Experimental Toxicology 24, Nr. 9 (September 2005): 453–58. http://dx.doi.org/10.1191/0960327105ht558oa.
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Econazole is an antifungal drug with different in vitro effects. However, econazole's effect on osteoblast like cells is unknown. In human MG63 osteosarcoma cells, the effect of econazole on intracellular Ca2+ concentrations ([Ca2+]i) was explored by using fura-2. At a concentration of 0.1 μM, econazole started to cause a rise in [Ca2+]i in a concentration-dependent manner. Econazole-induced [Ca2+]i rise was reduced by 74% by removal of extracellular Ca2+. The econazole-induced Ca2+ influx was mediated via a nimodipine-sensitive pathway. In Ca2+ free medium, thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+ ATPase, caused a [Ca2+]i rise, after which the increasing effect of econazole on [Ca2+]i was abolished. Pretreatment of cells with econazole to deplete Ca2+ stores totally prevented thapsigargin from releasing Ca2+. U73122, an inhibitor of phospholipase C, abolished histamine (an inositol 1,4,5-trisphosphate dependent Ca2+ mobilizer)-induced, but not econazoleinduced, [Ca2+]i rise. Econazole inhibited 76% of thapsigargin-induced store-operated Ca2+ entry. These findings suggest that in MG63 osteosarcoma cells, econazole increases [Ca2+]i by stimulating Ca2+ influx and Ca2+ release from the endoplasmic reticulum via a phospholipase C-independent manner. In contrast, econazole acts as a potent blocker of store-operated Ca2+ entry.
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Bennett, Brian D., Ulises Alvarez und Keith A. Hruska. „Receptor-Operated Osteoclast Calcium Sensing*“. Endocrinology 142, Nr. 5 (01.05.2001): 1968–74. http://dx.doi.org/10.1210/endo.142.5.8125.
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Abstract Osteoclasts “sense” elevated extracellular calcium, which leads to cytoskeletal changes that may be linked to phospholipase C (PLC) activation and the associated rise in intracellular calcium ([Ca2+]i). Since PLC is linked to transient receptor potential channels (trp), we hypothesized that receptor activated calcium influx due to this channel type would be activated by osteoclasts sensing [Ca2+]e. We found that high [Ca2+]e induced similar intracellular Ca2+ rises in chicken osteoclasts with or without intracellular Ca2+ store depletion by either TPEN or thapsigargin, thus defining store-insensitive Ca2+ influx. This store-insensitive calcium sensing component was blocked by the PLC antagonist U73122. Also, the calcium channel inhibitor SKF 96365, a blocker of store-independent trp-like channels, was effective in inhibiting calcium sensing in the presence of thapsigargin. Thus, a store-independent component of calcium sensing was associated with ion channels linked to PLC. Since receptor activated transient receptor potential (trp) family cation channels open in a PLC-dependent and store-independent manner, we suggest that receptor operated channels are activated in osteoclasts stimulated by high extracellular Ca2+.
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HALLER, Thomas, Harald VÖLKL, Peter DEETJEN und Paul DIETL. „The lysosomal Ca2+ pool in MDCK cells can be released by ins(1,4,5)P3-dependent hormones or thapsigargin but does not activate store-operated Ca2+ entry“. Biochemical Journal 319, Nr. 3 (01.11.1996): 909–12. http://dx.doi.org/10.1042/bj3190909.
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In several cell types, Ca2+ release from intracellular Ca2+ stores by Ins(1,4,5)P3 elicits Ca2+ influx from the extracellular space into the cytoplasm, termed store-operated Ca2+ entry (SOCE). In MDCK cells, the Ins(1,4,5)P3-sensitive Ca2+ store giving rise to SOCE essentially overlaps with the thapsigargin (TG)-sensitive store. Recent evidence suggests that in MDCK cells lysosomes form a Ca2+ pool that is functionally coupled with the Ins(1,4,5)P3-sensitive Ca2+ store: Ca2+ can be selectively released from lysosomes by glycyl-L-phenylalanine naphthylamide, an agent inducing lysosomal swelling with subsequent and reversible permeabilization of the vesicular membranes. This compartment is also depleted by Ins(1,4,5)P3-dependent agonists or TG, indicating that it is part of a larger, Ins(1,4,5)P3-sensitive Ca2+ pool. Here we show that whereas SOCE is triggered by Ca2+ release from the entire Ins(1,4,5)P3-sensitive Ca2+ pool, selective Ca2+ release from lysosomes alone is unable to trigger SOCE. This finding is consistent with measurements of the store-operated cation current, a direct parameter for store-operated Ca2+ and Na+ entry into MDCK cells. Hence it is proposed that the Ins(1,4,5)P3-sensitive Ca2+ pool is composed of different intracellular compartments that do not uniformly stimulate Ca2+ entry into the cell.
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Chien, Jau-Min, Chiang-Ting Chou, Chih-Chuan Pan, Chun-Chi Kuo, Jeng-Yu Tsai, Wei-Chuan Liao, Daih-Huang Kuo et al. „The mechanism of sertraline-induced [Ca2+]i rise in human OC2 oral cancer cells“. Human & Experimental Toxicology 30, Nr. 10 (19.01.2011): 1635–43. http://dx.doi.org/10.1177/0960327110396523.
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Effect of sertraline, an antidepressant, on cytosolic free Ca2+ levels ([Ca2+]i) in human cancer cells is unclear. This study examined if sertraline altered basal [Ca2+]i levels in suspended OC2 human oral cancer by using fura-2 as a Ca2+-sensitive fluorescent probe. At concentrations of 10−100 μM, sertraline induced a [Ca2+]i rise in a concentration-dependent fashion. The Ca2+ signal was reduced partly by removing extracellular Ca2+ indicating that Ca2+ entry and release both contributed to the [Ca2+]i rise. Sertraline induced Mn2+ influx, leading to quench of fura-2 fluorescence suggesting Ca2+ influx. This Ca2+ influx was inhibited by suppression of phospholipase A2, inhibition of store-operated Ca2+ channels or by modulation of protein kinase C activity. In Ca2+-free medium, pretreatment with the endoplasmic reticulum Ca2+ pump inhibitor thapsigargin or 2,5-di-(t-butyl)-1,4-hydroquinone (BHQ) nearly abolished sertraline-induced Ca2+ release. Conversely, pretreatment with sertraline greatly reduced the inhibitor-induced [Ca2+]i rise, suggesting that sertraline released Ca2+ from the endoplasmic reticulum. Inhibition of phospholipase C did not change sertraline-induced [Ca2+]i rise. Together, in human oral cancer cells, sertraline induced [Ca2+]i rises by causing phospholipase C-independent Ca2+ release from the endoplasmic reticulum and Ca2+ influx via store-operated Ca2+ channels.
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Shen, Ai-Yu, Mei-Han Huang, Trey-Shy Wang, Hui-Ming Wu, Ya-Fei Kang und Chi-Lan Chen. „Thymol-evoked Ca2+ Mobilization and Ion Currents in Pituitary GH3 Cells“. Natural Product Communications 4, Nr. 6 (Juni 2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400601.
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In this study, an attempt was made to elucidate the effects of thymol, a monocyclic phenolic compound, on Ca2+ mobilization and ion currents in pituitary GH3 cells with the aid of fura-2 fluorimetry and the whole-cell voltage-clamp technique. Thymol increased intracellular Ca2+ concentrations ([Ca2+]i) in GH3 cells loaded with Ca2+-sensitive dye fura-2. Removing extracellular Ca2+ reduced the thymol-induced [Ca2+]i rise. In Ca2+-free solution, thymol-evoked [Ca2+]i rise was unchanged by depleting the Ca2+ store with thapsigargin (1 μM), while the thapsigargin-induced [Ca2+]i rise was reduced by pretreatment with thymol. These results imply that the Ca2+ stores depleted by thymol comprise thapsigargin-sensitive and thapsigargin-insensitive pools. In addition, after depletion of the internal Ca2+ store with 100 μM thymol in Ca2+-free solution, a subsequent application of Ca2+ greatly induced a [Ca2+]i increase. The results indicate that, similar to thapsigargin, 100 μM thymol may activate the capacitative calcium entry (CCE) channel. However, thymol (100 μM) had a slight depressant action in L-type calcium current ( ICaL). The stimulatory actions of thymol on Ca2+ signaling may partly be responsible for the underlying cellular mechanisms through which it affects neuroendocrine functions.
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Zhang, Shen, Jason X. J. Yuan, Kim E. Barrett und Hui Dong. „Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells“. American Journal of Physiology-Cell Physiology 288, Nr. 2 (Februar 2005): C245—C252. http://dx.doi.org/10.1152/ajpcell.00411.2004.
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A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMC) is an important stimulus for cell contraction, migration, and proliferation. Depletion of intracellular Ca2+ stores opens store-operated Ca2+ channels (SOC) and causes Ca2+ entry. Transient receptor potential (TRP) cation channels that are permeable to Na+ and Ca2+ are believed to form functional SOC. Because sarcolemmal Na+/Ca2+ exchanger has also been implicated in regulating [Ca2+]cyt, this study was designed to test the hypothesis that the Na+/Ca2+ exchanger (NCX) in cultured human PASMC is functionally involved in regulating [Ca2+]cyt by contributing to store depletion-mediated Ca2+ entry. RT-PCR and Western blot analyses revealed mRNA and protein expression for NCX1 and NCKX3 in cultured human PASMC. Removal of extracellular Na+, which switches the Na+/Ca2+ exchanger from the forward (Ca2+ exit) to reverse (Ca2+ entry) mode, significantly increased [Ca2+]cyt, whereas inhibition of the Na+/Ca2+ exchanger with KB-R7943 (10 μM) markedly attenuated the increase in [Ca2+]cyt via the reverse mode of Na+/Ca2+ exchange. Store depletion also induced a rise in [Ca2+]cyt via the reverse mode of Na+/Ca2+ exchange. Removal of extracellular Na+ or inhibition of the Na+/Ca2+ exchanger with KB-R7943 attenuated the store depletion-mediated Ca2+ entry. Furthermore, treatment of human PASMC with KB-R7943 also inhibited cell proliferation in the presence of serum and growth factors. These results suggest that NCX is functionally expressed in cultured human PASMC, that Ca2+ entry via the reverse mode of Na+/Ca2+ exchange contributes to store depletion-mediated increase in [Ca2+]cyt, and that blockade of the Na+/Ca2+ exchanger in its reverse mode may serve as a potential therapeutic approach for treatment of pulmonary hypertension.
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Coibion, Olivier, Yuriy Gorodnichenko und Dmitri Koustas. „Consumption Inequality and the Frequency of Purchases“. American Economic Journal: Macroeconomics 13, Nr. 4 (01.10.2021): 449–82. http://dx.doi.org/10.1257/mac.20190115.
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We document a decline in the frequency of shopping trips in the United States since 1980 and consider its implications for the measurement of consumption inequality. A decline in shopping frequency as households stock up on storable goods (i.e., inventory behavior) will lead to a rise in expenditure inequality when the latter is measured at high frequency, even when underlying consumption inequality is unchanged. We find that most of the recently documented rise in expenditure inequality in the United States since the 1980s can be accounted for by this phenomenon. Using detailed micro data on spending, which we link to data on club/warehouse store openings, we directly attribute much of the reduced frequency of shopping trips to the rise in club/warehouse stores. (JEL D12, D31, D63, D91, E21)
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Sage, S. O., E. Pintado, M. P. Mahaut-Smith und J. E. Merritt. „Rapid kinetics of agonist-evoked changes in cytosolic free Ca2+ concentration in fura-2-loaded human neutrophils“. Biochemical Journal 265, Nr. 3 (01.02.1990): 915–18. http://dx.doi.org/10.1042/bj2650915.
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The initial kinetics of agonist-evoked rises in the cytosolic Ca2+ concentration [Ca2+]i were investigated in fura-2-loaded human neutrophils by stopped-flow fluorimetry. The rises in [Ca2+]i evoked by chemotactic peptide (fMet-Leu-Phe), platelet-activating factor and ADP all lagged behind agonist addition by 1-1.3 s. Lag times were not significantly different in the presence and in the absence of external Ca2+. Stimulation of the cells in the presence of extracellular Mn2+ resulted in a quench of fluorescence with a similar lag time to [Ca2+]i rise. The delay in onset of the rise in [Ca2+]i evoked by fMet-Leu-Phe was dependent on concentration, becoming longer at lower concentrations of agonist. These results indicate that both the agonist-evoked discharge of the intracellular Ca2+ stores and the generation of bivalent-cation influx lag behind agonist-receptor binding in neutrophils. Both pathways thus appear to be mediated by indirect mechanisms, rather than by a directly coupled process such as a receptor-operated channel. The temporal coincidence of the onset of store discharge with the commencement of bivalent-cation influx suggests that the two events may be causally linked.
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Wadman, Meredith. „Plan to alter access to health data draws ire“. Science 384, Nr. 6697 (17.05.2024): 726. http://dx.doi.org/10.1126/science.adq4553.
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Dickenson, J. M., und S. J. Hill. „Histamine H1-receptor-mediated calcium influx in DDT1MF-2 cells“. Biochemical Journal 284, Nr. 2 (01.06.1992): 425–31. http://dx.doi.org/10.1042/bj2840425.
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Undifferentiated monolayers of the hamster vas deferens smooth-muscle cell line, DDT1MF-2, were grown on glass coverslips and loaded with the Ca(2+)-sensitive fluorescent dye fura-2. Stimulation with histamine produced a rapid and maintained increase in intracellular free Ca2+ ([Ca2+]i), with an EC50 of 7.0 +/- 0.7 microM. The initial rise in [Ca2+]i can be attributed to Ca2+ release from intracellular stores, whereas the maintained or plateau phase is due to influx of extracellular Ca2+. The Ca2+ influx associated with the plateau phase required the continued presence of histamine on the receptor, since the H1-antagonist mepyramine (10 microM) attenuated the rise in [Ca2+]i observed when extracellular Ca2+ was re-applied after the cells had been stimulated with histamine, in experiments performed in nominally Ca(2+)-free buffer. Pretreatment with the inorganic Ca(2+)-channel blockers Ni2+ (1 mM) and Co2+ (1 mM) inhibited the influx component, whereas the organic voltage-operated Ca(2+)-channel antagonists nifedipine (10 microM) and PN-200-110 (10 microM) had no effect. These data suggest that histamine stimulates Ca2+ influx through an H1-receptor-activated Ca2+ channel. Experiments with Mn2+ indicated that the receptor-mediated Ca(2+)-influx pathway(s) is impermeable to Mn2+. Furthermore, the refilling of Ca2+ stores can occur independently of H1-receptor-mediated influx, since store refilling can be demonstrated even when the receptor-mediated Ca2+ entry is blocked by mepyramine. In conclusion, H1-receptor activation in the smooth-muscle cell line DDT1MF-2 stimulates both release of Ca2+ from intracellular stores [inositol 1,4,5-triphosphate (InsP3)-mediated] and Ca2+ influx through a receptor-activated Ca2+ channel. The subsequent refilling of the InsP3-sensitive intracellular Ca2+ store is independent of histamine H1-receptor stimulation (mepyramine-insensitive) and occurs without an observable rise in cytosolic free Ca2+.
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Arnon, Assaf, John M. Hamlyn und Mordecai P. Blaustein. „Na+ entry via store-operated channels modulates Ca2+signaling in arterial myocytes“. American Journal of Physiology-Cell Physiology 278, Nr. 1 (01.01.2000): C163—C173. http://dx.doi.org/10.1152/ajpcell.2000.278.1.c163.
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In many nonexcitable cells, hormones and neurotransmitters activate Na+ influx and mobilize Ca2+ from intracellular stores. The stores are replenished by Ca2+influx via “store-operated” Ca2+ channels (SOC). The main routes of Na+ entry in these cells are unresolved, and no role for Na+ in signaling has been recognized. We demonstrate that the SOC are a major Na+ entry route in arterial myocytes. Unloading of the Ca2+stores with cyclopiazonic acid (a sarcoplasmic reticulum Ca2+ pump inhibitor) and caffeine induces a large external Na+-dependent rise in the cytosolic Na+ concentration. One component of this rise in cytosolic Na+ concentration is likely due to Na+/Ca2+exchange; it depends on elevation of cytosolic Ca2+ and is insensitive to 10 mM Mg2+ and 10 μM La3+. Another component is inhibited by Mg2+ and La3+, blockers of SOC; this component persists in cells preloaded with 1,2-bis(2-aminophenoxy)ethane- N, N, N′, N′-tetraacetic acid to buffer Ca2+ transients and prevent Na+/Ca2+exchange-mediated Na+ entry. This Na+ entry apparently is mediated by SOC. The Na+ entry influences Na+ pump activity and Na+/Ca2+exchange and has unexpectedly large effects on cell-wide Ca2+ signaling. The SOC pathway may be a general mechanism by which Na+ participates in signaling in many types of cells.
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Fang, Yi-Chien, Daih-Huang Kuo, Pochuen Shieh, Fu-An Chen, Chun-Chi Kuo und Chung-Ren Jan. „Effect of m-3M3FBS on Ca2+ movement in Madin-Darby canine renal tubular cells“. Human & Experimental Toxicology 28, Nr. 10 (21.09.2009): 655–63. http://dx.doi.org/10.1177/0960327109106972.
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The effect of 2,4,6-trimethyl-N-(meta-3-trifluoromethyl-phenyl)-benzenesulfonamide (m-3M3FBS), a presumed phospholipase C (PLC) activator, on cytosolic free Ca2+ concentrations ([Ca 2+]i) in Madin-Darby canine kidney (MDCK) cells is unclear. This study explored whether m-3M3FBS changed basal [Ca2+]i levels in suspended MDCK cells using fura-2 as a Ca2+-sensitive fluorescent dye. M-3M3FBS at concentrations between 0.1 and 20 μM increased [Ca2+]i in a concentration-dependent manner. The Ca2+ signal was decreased by removing extracellular Ca2+. M-3M3FBS-induced Ca2+ influx was inhibited by the store-operated Ca2+ channel blockers nifedipine, econazole, and SK&F96365, and by the phospholipase A2 inhibitor aristolochic acid. In Ca2+-free medium, 20-μM m-3M3FBS pretreatment abolished the [Ca2+]i rise induced by the endoplasmic reticulum Ca2+ pump inhibitors thapsigargin (TG) and cyclopiazonic acid (CPA). Conversely, pretreatment with TG or CPA partly reduced m-3M3FBS-induced [Ca2+]i rise. The inhibition of PLC with U73122 did not alter m-3M3FBS-induced [Ca2+]i rise. Collectively, in MDCK cells, m-3M3FBS induced [Ca2+]i rises by causing PLC-independent Ca2+ release from the endoplasmic reticulum and Ca2+ influx via store-operated Ca2+ channels and other unidentified Ca2+ channels.
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Rosanoff, Andrea, und Diriba B. Kumssa. „Impact of rising body weight and cereal grain food processing on human magnesium nutrition“. Plant and Soil 457, Nr. 1-2 (14.03.2020): 5–23. http://dx.doi.org/10.1007/s11104-020-04483-7.
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Abstract Aim The World Health Organisation (WHO) magnesium (Mg) estimated average requirement (EAR) is not adjusted for rise in human body weight (BW) and neglects body Mg stores depletion. Cereal grain food processing results in Mg loss and reduces dietary Mg intake which mainly originates from cereals. Here we reassess human dietary Mg deficiency risk considering actual human BWs and modern levels of cereal grain food processing. Methods Human Mg requirement was adjusted for rising BW plus low and high estimates to prevent body Mg store depletion. Magnesium supply was recalculated for cereal grain (maize, millet, rice, oats, sorghum, and wheat) food processing of none, 25%, 50%, 75% and 100%. Resulting Mg deficiency risks in 1992 and 2011 were calculated at national, regional, continental and global scales using the EAR cut-point method. Results Globally, human Mg requirement increased by 4–118% under the three Mg requirement scenarios compared to the WHO EARs set in 1998. However, dietary Mg supply declined with increased cereal grain food processing. At 100% cereal grain processing, dietary Mg supply was reduced by 56% in 1992 and 51% in 2011. Global human Mg deficiency risk reached 62% in 2011 with 100% cereal grain processing and largest EAR set to prevent depletion of body Mg stores and corrected for BW rises. Conclusion Global dietary Mg Supply adequately meets human Mg requirement given the global obesity epidemic. But, Mg intakes preventing body Mg store depletion plus high Mg losses due to cereal grain food processing start to show noteworthy risks of potential Mg deficit in populations consuming diets with >50% cereal grain food processing. These findings have ramifications for the global spread of the major chronic, non-communicable diseases associated with nutritional Mg deficiencies such as cardiovascular diseases and type 2 diabetes.
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Hulme, Alison. „The rise and rise of the pound store: functionality and freedom under austerity“. History of Retailing and Consumption 2, Nr. 3 (September 2016): 165–70. http://dx.doi.org/10.1080/2373518x.2016.1227922.
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Klassen, Henry C. „T. C. Power & Bro.: The Rise of a Small Western Department Store, 1870–1902“. Business History Review 66, Nr. 4 (1992): 671–722. http://dx.doi.org/10.2307/3116844.
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When studying retailing and its role in developing the American mass market, historians traditionally have focused their attention on large department stores. An analysis of the influence of small department stores in the growth of underdeveloped sections of the American West provides a different emphasis. The following article traces the history of T. C. Power & Bro.—a small, family-run department store in Montana—before the early 1900s. The article demonstrates that the firm's service was tailored to the economic and social needs of urban and rural settlers on the western frontier, helping to create a consumer society in the West.
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Lawrence, Jeanne Catherine. „Geographical space, social space, and the realm of the department store“. Urban History 19, Nr. 1 (April 1992): 64–83. http://dx.doi.org/10.1017/s0963926800009639.
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Over the past decade a number of scholars have examined the rise of the mass production and distribution of goods, and the concurrent emergence of a nineteenth- and twentieth-century consumer society or ‘culture of consumption’. This body of work has featured the department store prominently in several roles: as a venue for the distribution of consumer goods; as a material fantasyland in which women were encouraged to play out their dreams of conspicuous consumption; and as a place of white-collar employment for working-class clerks. Whatever their focus, these accounts generally view all department stores as homogeneous middle-class institutions, located in a similarly consistent ‘downtown’ in any (and all) large American and European cities. There are serious flaws in such a portrayal. Very real distinctions between department stores in a given city and the social implications of these differences in terms of social status and class are not addressed. Further, the contribution of the built environment and urban topography to the shaping of these status and class distinctions and, ultimately, women's shopping experience, is likewise overlooked. This article examines a set of surveys and marketing reports prepared in 1932 for the Higbee Company of Cleveland, Ohio, in order to situate more precisely one department store within its urban context. These sources document the relationship of the Higbee Company to the city's other department stores and in so doing reveal some of the ways in which stratification between and among classes was interpreted in terms of geographical and social space. Examination of the hierarchy of stores that existed in what was at the time the nation's sixth largest city provides a corrective to the image of the department store as a homogeneous democratic phenomenon, and thus provides an invaluable basis for a reinterpretation of the department store as an urban institution in early twentieth- century America.
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Eagle, John A., und Joy L. Santink. „Timothy Eaton and the Rise of His Department Store.“ American Historical Review 96, Nr. 5 (Dezember 1991): 1643. http://dx.doi.org/10.2307/2165478.
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Bohmer, Richard. „The Rise of In-Store Clinics — Threat or Opportunity?“ New England Journal of Medicine 356, Nr. 8 (22.02.2007): 765–68. http://dx.doi.org/10.1056/nejmp068289.
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Sweeney, Michele, Sharon S. McDaniel, Oleksandr Platoshyn, Shen Zhang, Ying Yu, Bethany R. Lapp, Ying Zhao, Patricia A. Thistlethwaite und Jason X. J. Yuan. „Role of capacitative Ca2+ entry in bronchial contraction and remodeling“. Journal of Applied Physiology 92, Nr. 4 (01.04.2002): 1594–602. http://dx.doi.org/10.1152/japplphysiol.00722.2001.
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Asthma is characterized by airway inflammation, bronchial hyperresponsiveness, and airway obstruction by bronchospasm and bronchial wall thickening due to smooth muscle hypertrophy. A rise in cytosolic free Ca2+ concentration ([Ca2+]cyt) may serve as a shared signal transduction element that causes bronchial constriction and bronchial wall thickening in asthma. In this study, we examined whether capacitative Ca2+ entry (CCE) induced by depletion of intracellular Ca2+ stores was involved in agonist-mediated bronchial constriction and bronchial smooth muscle cell (BSMC) proliferation. In isolated bronchial rings, acetylcholine (ACh) induced a transient contraction in the absence of extracellular Ca2+ because of Ca2+ release from intracellular Ca2+ stores. Restoration of extracellular Ca2+in the presence of atropine, an M-receptor blocker, induced a further contraction that was apparently caused by a rise in [Ca2+]cyt due to CCE. In single BSMC, amplitudes of the store depletion-activated currents ( I SOC) and CCE were both enhanced when the cells proliferate, whereas chelation of extracellular Ca2+ with EGTA significantly inhibited the cell growth in the presence of serum. Furthermore, the mRNA expression of TRPC1, a transient receptor potential channel gene, was much greater in proliferating BSMC than in growth-arrested cells. Blockade of the store-operated Ca2+channels by Ni2+ decreased I SOC and CCE and markedly attenuated BSMC proliferation. These results suggest that upregulated TRPC1 expression, increased I SOC, enhanced CCE, and elevated [Ca2+]cyt may play important roles in mediating bronchial constriction and BSMC proliferation.
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Sage, S. O., R. Reast und T. J. Rink. „ADP evokes biphasic Ca2+ influx in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store“. Biochemical Journal 265, Nr. 3 (01.02.1990): 675–80. http://dx.doi.org/10.1042/bj2650675.
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Stopped-flow fluorimetric studies at 37 degrees C have shown that ADP, at optimal concentrations, can evoke Ca2+ or Mn2+ influx in fura-2-loaded human platelets without measurable delay. In contrast, the release of Ca2+ from intracellular stores is delayed in onset by about 200 ms. By working at a lower temperature, 17 degrees C, we have now shown that the rise in cytosolic calcium concentration ([Ca2+]i) evoked by ADP in the presence of external Ca2+ is biphasic. The use of Mn2+ as a tracer for bivalent-cation entry indicates that both phases of the ADP-evoked response are associated with influx. The fast phase of the ADP-evoked rise in [Ca2+]i, which occurs without measurable delay at both 17 degrees C and 37 degrees C, is consistent with Ca2+ entry mediated by receptor-operated channels in the plasma membrane. The delayed phase, indicated by Mn2+ quench, is coincident with the discharge of the intracellular Ca2+ stores. Forskolin did not inhibit the fast phases of ADP-evoked rise in [Ca2+]i or Mn2+ quench, but completely abolished ADP-evoked discharge of the intracellular stores, the delayed phase of the rise in [Ca2+]i observed in the presence of external Ca2+ and the second phase of Mn2+ quench. The timing of the delayed event appears to be modulated by [Ca2+]i: the delayed phase of Mn2+ quench coincides with discharge of the intracellular stores in the absence of added Ca2+, but with the second phase of the ADP-evoked rise in [Ca2+]i in the presence of extracellular Ca2+. Similarly, blockade of the early phase of Ca2+ entry by SK&F 96365 further delays the second phase. It is suggested that a pathway for Ca2+ entry which is regulated by the intracellular Ca2+ store exists in platelets. This pathway operates alongside, and appears to be modulated by the activity of other routes for Ca2+ entry into the cytosol.
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Morgan, A. J., und R. Jacob. „Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane“. Biochemical Journal 300, Nr. 3 (15.06.1994): 665–72. http://dx.doi.org/10.1042/bj3000665.
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In fura-2-loaded ECV304 cells ionomycin elicited a saturable biphasic change in intracellular Ca2+ concentration ([Ca2+]i), where the initial phase represented mobilization of intracellular stores and the sustained component represented Ca2+ influx. To examine whether ionomycin could stimulate influx via a store-dependent mechanism. Mn2+ entry was monitored by the quenching of fura-2 fluorescence: influx was enhanced even after ionomycin wash-out, provided that internal stores were not refilled with Ca2+. Moreover, the maximal rate of histamine-stimulated Mn2+ entry was unaffected by ionomycin, suggesting a common route of entry. The Ca(2+)-entry blocker SK&F 96365 inhibited both the ionomycin-induced Mn2+ entry and the sustained [Ca2+]i response to the ionophore (leaving the initial peak [Ca2+]i response unaffected). In other experiments, although addition of ionomycin further increased the plateau phase induced by 100 microM histamine, the increase was completely abolished by pretreatment with the store Ca(2+)-ATPase inhibitor cyclopiazonic acid (CPA). Furthermore, in store-depleted cells, re-addition of 1 mM extracellular Ca2+ (in the presence of CPA plus histamine) led to a rapid rise in [Ca2+]i, dependent on Ca2+ influx, with kinetics that were not enhanced by ionomycin. These data suggest that ionomycin acts primarily at the level of the internal Ca2+ stores, so that, at the concentrations used here (< or = 1 microM), it increases Ca2+ (and Mn2+) influx via activation of endogenous entry pathways and not by plasmalemmal translocation.
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López, José J., Cristina Camello-Almaraz, José A. Pariente, Ginés M. Salido und Juan A. Rosado. „Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets“. Biochemical Journal 390, Nr. 1 (09.08.2005): 243–52. http://dx.doi.org/10.1042/bj20050168.
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Most physiological agonists increase cytosolic free [Ca2+]c (cytosolic free Ca2+ concentration) to regulate a variety of cellular processes. How different stimuli evoke distinct spatiotemporal Ca2+ responses remains unclear, and the presence of separate intracellular Ca2+ stores might be of great functional relevance. Ca2+ accumulation into intracellular compartments mainly depends on the activity of Ca2+- and H+-ATPases. Platelets present two separate Ca2+ stores differentiated by the distinct sensitivity to thapsigargin and TBHQ [2,5-di-(t-butyl)-1,4-hydroquinone]. Although one store has long been identified as the dense tubular system, the nature of the TBHQ-sensitive store remains uncertain. Treatment of platelets with GPN (glycylphenylalanine-2-naphthylamide) impaired Ca2+ release by TBHQ and reduced that evoked by thrombin. In contrast, GPN did not modify Ca2+ mobilization stimulated by ADP or AVP ([arginine]vasopressin). Treatment with nigericin, a proton carrier, and bafilomycin A1, an inhibitor of the vacuolar H+-ATPase, to dissipate the proton gradient into acidic organelles induces a transient increase in [Ca2+]c that was abolished by previous treatment with the SERCA (sarcoplasmic/endoplasmic-reticulum Ca2+-ATPase) 3 inhibitor TBHQ. Depleted acidic stores after nigericin or bafilomycin A1 were refilled by SERCA 3. Thrombin, but not ADP or AVP, reduces the rise in [Ca2+]c evoked by nigericin and bafilomycin A1. Our results indicate that the TBHQ-sensitive store in human platelets is an acidic organelle whose Ca2+ accumulation is regulated by both Ca2+- and vacuolar H+-ATPases.
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Kushidayati, Lina. „Quran Apps in Playstore: The Problem of Authentication and Religious Authority“. FIKRAH 7, Nr. 1 (24.06.2019): 155. http://dx.doi.org/10.21043/fikrah.v7i1.4801.
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This article discuss about an application at Google Play Store that appears along with the rise of smartphone usage. It's also take effect to Muslims live style and religious practice, for example in reading Quran. There are many Quran applications are available on the Play store, its raises questions on religious authorities because anyone can upload an Android-based Quran application on the Play store. A descriptive qualitative approach use to analyze Qur’an apps in Google Play store. The apps are chosen based on the numbers of download and comments from the users. The results show that the growth of digital Quran applications raises new styles of worship such as reading the Quran on smarthphone application.
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Kairupan, Natasha Helena, Susanne Dida und Heru Ryanto Budiana. „CORPORATE REBRANDING OF GRAMEDIA STORE (CORPORATE REBRANDING DI GRAMEDIA STORE)“. EDUTECH 15, Nr. 3 (18.01.2017): 265. http://dx.doi.org/10.17509/edutech.v15i3.4872.
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Abstract. The purposes of this research are to determine the stages of analysis, planning, and evaluation of corporate rebranding process of Gramedia Book Store to be Gramedia Store to rise stakeholder’s awareness. The method used is descriptive qualitative with positivism paradigm. The technique of collecting data through in-depth interview, observation, and literature study. The result of this research showed the analysis stage by analyzing the market through insights and foresights, brand audit through SWOT analysis, and identifying opportunities. The planning stage is by determine the purpose of the planning process and then determine the target audience, consist of external and internal customer. The planning of external customer by renaming and change of corporate identity, and marketing planning using communication channel (above the line and below the line). The planning of internal customer by Brand Induction, training, inspiration briefing at store, and innovation competition. The evaluation of rebranding process of Gramedia Store is having a focus group discussion with customer, media monitoring, and presentation to BOD.Keywords : Process, Corporate Rebranding, Stakeholder Awareness, Corporate Identity, Gramedia StoreAbstrak.Tujuan penelitian ini adalah untuk mengetahui bagaimana tahapan analisis, perencanaan, dan evaluasi proses corporate rebranding Gramedia Book Store menjadi Gramedia Store untuk meningkatkan stakeholder awareness. Pendekatan yang digunakan adalah kualitatif dengan paradigma positivisme dan jenis studi deksriptif. Teknik pengumpulan data yang dilakukan melalui wawancara mendalam, observasi, dan studi pustaka. Berdasarkan hasil penelitian, tahapan analisis dilakukan dengan menganalisis pasar melalui insights dan foresights, audit merek dengan analisis SWOT, dan mengidentifikasi peluang. Dalam tahapan perencanaan dengan menentukan tujuan kemudian menentukan target audiens, yaitu eksternal dan internal. Perencanaan kepada external customer dilakukan dengan perubahan nama dan identitas perusahaan, melakukan perencanaan publikasi dan pemasaran menggunakan saluran komunikasi baik above the line dan below the line. Perencanaan kepada internal customer dilakukan dengan mengadakan brand induction, training, briefing inspirasi, dan lomba inovasi. Evaluasi dalam proses rebranding Gramedia Store dilakukan dengan focus group discussion dengan customer, media monitoring, dan presentasi ke BOD.Kata kunci : Proses, Corporate Rebranding, Stakeholder Awareness, Identitas Perusahaan, Gramedia Store
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Poel, Dirk Van den, und Joseph Leunis. „Perceived risk and rise reduction strategies in mail-order versus retail store buying“. International Review of Retail, Distribution and Consumer Research 6, Nr. 4 (Oktober 1996): 351–71. http://dx.doi.org/10.1080/09593969600000039.
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Hernández-Cruz, Arturo, Ariel L. Escobar und Nicolás Jiménez. „Ca2+-induced Ca2+ Release Phenomena in Mammalian Sympathetic Neurons Are Critically Dependent on the Rate of Rise of Trigger Ca2+“. Journal of General Physiology 109, Nr. 2 (01.02.1997): 147–67. http://dx.doi.org/10.1085/jgp.109.2.147.
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The role of ryanodine-sensitive intracellular Ca2+ stores present in nonmuscular cells is not yet completely understood. Here we examine the physiological parameters determining the dynamics of caffeine-induced Ca2+ release in individual fura-2–loaded sympathetic neurons. Two ryanodine-sensitive release components were distinguished: an early, transient release (TR) and a delayed, persistent release (PR). The TR component shows refractoriness, depends on the filling status of the store, and requires caffeine concentrations ≥10 mM. Furthermore, it is selectively suppressed by tetracaine and intracellular BAPTA, which interfere with Ca2+-mediated feedback loops, suggesting that it constitutes a Ca2+-induced Ca2+-release phenomenon. The dynamics of release is markedly affected when Sr2+ substitutes for Ca2+, indicating that Sr2+ release may operate with lower feedback gain than Ca2+ release. Our data indicate that when the initial release occurs at an adequately fast rate, Ca2+ triggers further release, producing a regenerative response, which is interrupted by depletion of releasable Ca2+ and Ca2+-dependent inactivation. A compartmentalized linear diffusion model can reproduce caffeine responses: When the Ca2+ reservoir is full, the rapid initial Ca2+ rise determines a faster occupation of the ryanodine receptor Ca2+ activation site giving rise to a regenerative release. With the store only partially loaded, the slower initial Ca2+ rise allows the inactivating site of the release channel to become occupied nearly as quickly as the activating site, thereby suppressing the initial fast release. The PR component is less dependent on the store's Ca2+ content. This study suggests that transmembrane Ca2+ influx in rat sympathetic neurons does not evoke widespread amplification by CICR because of its inability to raise [Ca2+] near the Ca2+ release channels sufficiently fast to overcome their Ca2+-dependent inactivation. Conversely, caffeine-induced Ca2+ release can undergo considerable amplification especially when Ca2+ stores are full. We propose that the primary function of ryanodine-sensitive stores in neurons and perhaps in other nonmuscular cells, is to emphasize subcellular Ca2+ gradients resulting from agonist-induced intracellular release. The amplification gain is dependent both on the agonist concentration and on the filling status of intracellular Ca2+ stores.
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O'Sullivan, A. J., und R. D. Burgoyne. „A comparison of bradykinin, angiotensin II and muscarinic stimulation of cultured bovine adrenal chromaffin cells“. Bioscience Reports 9, Nr. 2 (01.04.1989): 243–52. http://dx.doi.org/10.1007/bf01116001.
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Bradykinin, angiotensin II and a mascarnic agonist, acetyl-B-methacholine (methacholine) were all found to elict catecholamine release from cultured bovine adrenal chromaffin cells. Bradykinin was the most potent of these secretagogues and methacholine the weakest, with angiotenin II intermediate in efficacy. All three secretagogues were much less effective than nicotinic stimulation. The three secretagogues all produced a rise in cytoplasmic free calcium concentration ([Ca2+]i), measured with the fluorescent indicator fura2, which was partially independent of external calcium. In the case of bradykinin the full rise in ([Ca2+]i) may involve a component of calcium entry in addition to release of calcium from an internal store. Secretion was also found to be partially independent of external calcium. The different efficacies of the three secretagogues in elicting secretion were correlated with the rise in ([Ca2+]i) produced. The differeing efficacies of the three secretagogues may be due to the extent of release of calcium from an intracellular store which itself is less effective in eliciting secretion than a rise in [Ca2+]i following calcium entry due to nicotine. Bradykinin also stimulates calcium entry, and this may increase the efficacy of the initial rise in [Ca2+]i. Treatment with pertussis toxin resulted in an enhancement of secretion in response to all of the secretagogues.
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Dastidar, Urshita Ghosh, Suhas Suresh Ambekar, Manoj Hudnurkar und Abhay D. Lidbe. „Experiential Retailing Leveraged by Data Analytics“. International Journal of Business Intelligence Research 12, Nr. 1 (Januar 2021): 98–113. http://dx.doi.org/10.4018/ijbir.20210101.oa6.
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The purpose of the study is to establish how in retail industry consumer data can be leveraged and analysed to provide customers an enhance shopping experience. Popular machine learning algorithms related to text mining aids in parsing the natural language and helps to understand the brand image and what the brand currently is lacking. In the last decade, although ecommerce brought a revolution in retail industry, shopping trends show that consumers spend more in offline store than online. The rise of omni-channel retailing and data-driven decision-making are shifting retailer focus to providing enhanced in-store customer experiences. Retailers are trying to find ways to stand out in the highly competitive environment. The solution to this problem is providing retailtainment. This study helps to understand how the available customer data is to be analysed to create unique experiences and enable experience-based stores. The results of this study will help a retail company understand how omnichannel play an important role creating customer engagement strategies.
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Paeizi, Alireza, und Ahmad Makui. „An integer linear programming approach for a location-allocation problem in online stores industry: A real world case study“. Journal of Future Sustainability 4, Nr. 2 (2024): 77–84. http://dx.doi.org/10.5267/j.jfs.2024.5.002.
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As the population grows and demand increases, cities have seen a rise in the number of chain stores. To remain competitive, these companies must reduce costs and attract more customers. A key factor in achieving this is the strategic placement of store branches, which reduces the distance between stores and customers, instilling trust and increasing their appeal while also cutting costs by reducing the need for employees to navigate longer distances. In this study, an integer linear programming model is presented with the goal of dividing a zone in Ahvaz city into several scenarios to determine the optimal number of stores while maintaining control over the distance between active stores. This research is the first to include this specific limitation in the mathematical model of the problem. The results of the study demonstrate a significant reduction in the distance between customers and stores.
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Mohr, F. C., und C. Fewtrell. „The effect of mitochondrial inhibitors on calcium homeostasis in tumor mast cells“. American Journal of Physiology-Cell Physiology 258, Nr. 2 (01.02.1990): C217—C226. http://dx.doi.org/10.1152/ajpcell.1990.258.2.c217.
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The depletion of intracellular ATP by mitochondrial inhibitors in a glucose-free saline solution inhibited antigen-stimulated 45Ca uptake, the rise in cytoplasmic calcium, measured by fura-2, and secretion in rat basophilic leukemia cells. Lowering the intracellular ATP concentration also released calcium from an intracellular store and made further 45Ca efflux from the cells unresponsive to subsequent antigen stimulation. Antigen-stimulated 45Ca efflux could be restored by the addition of glucose. The ATP-sensitive calcium store appeared to be the same store that releases calcium in response to antigen. In contrast, intracellular ATP was not lowered, and antigen-stimulated secretion was unaffected by mitochondrial inhibitors, provided that glucose was present in the bathing solution. Similarly, antigen-stimulated 45Ca uptake, 45Ca efflux, and the rise in free ionized calcium were unaffected by individual mitochondrial inhibitors in the presence of glucose. However, when the respiratory chain inhibitor antimycin A was used in combination with the ATP synthetase inhibitor oligomycin in the presence of glucose, antigen-stimulated 45Ca uptake was inhibited, whereas the rise in free ionized calcium and secretion were unaffected. Also, antigen-induced depolarization (an indirect measurement of Ca2+ influx across the plasma membrane) was not affected. The inhibition of antigen-stimulated 45Ca uptake could, however, be overcome if a high concentration of the Ca2+ buffer quin2 was present in the cells to buffer the incoming 45Ca. These results suggest that in fully functional rat basophilic leukemia cells the majority of the calcium entering in response to antigen stimulation is initially buffered by a calcium store sensitive to antimycin A and oligomycin, presumably the mitochondria.
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Latha, A., und M. Kirupa Priyadarsini. „The rise and fall of the mooc's -What's in store?“ JIMS8M The Journal of Indian Management & Strategy 28, Nr. 1 (2023): 58–62. http://dx.doi.org/10.5958/0973-9343.2023.00008.x.
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Chakraborty, Sumita, und Gaiti Hasan. „IP3R, store-operated Ca2+ entry and neuronal Ca2+ homoeostasis in Drosophila“. Biochemical Society Transactions 40, Nr. 1 (19.01.2012): 279–81. http://dx.doi.org/10.1042/bst20110618.
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The IP3R (inositol 1,4,5-trisphosphate receptor) releases Ca2+ from the ER (endoplasmic reticulum) store upon binding to its ligand InsP3, which is thought to be generated by activation of certain membrane-bound G-protein-coupled receptors in Drosophila. Depletion of Ca2+ in the ER store also activates SOCE (store-operated Ca2+ entry) from the extracellular milieu across the plasma membrane, leading to a second rise in cytosolic Ca2+, which is then pumped back into the ER. The role of the IP3R and SOCE in mediating Ca2+ homoeostasis in neurons, their requirement in neuronal function and effect on neuronal physiology and as a consequence behaviour, are reviewed in the present article.
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Wang, Xin, Xiaolin Zhu, Yunhang Wang und Long Lu. „Design of Payment System for Unmanned Convenience Store“. Frontiers in Science and Engineering 2, Nr. 7 (03.08.2022): 8–16. http://dx.doi.org/10.54691/fse.v2i7.1400.
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The unattended convenience store system for customers to pay and pick up goods by self-service has disclosed a project to add e-commerce concept to the retail industry. The rise of the Internet has made e-commerce develop rapidly, and the development of network payment and cloud service has escorted e-commerce.But so far, e-commerce is difficult to be applied in the retail field because of people's shopping habits.This project comprehensively considers various factors, uses mechanical and electrical equipment automation, comprehensive deployment of cloud server, and key generation and verification to realize e-commerce concept in retail field.
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Lloyd Mills, C., M. B. Hallett, M. A. McPherson und R. L. Dormer. „β-adrenergic mobilization of Ca2+ from an intracellular store in rat submandibular acini“. Biochemical Journal 293, Nr. 3 (01.08.1993): 691–95. http://dx.doi.org/10.1042/bj2930691.
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Increases in cytoplasmic free Ca2+ concentration in rat submandibular acini were observed in response to isoprenaline (10 microM), noradrenaline (10 microM) and carbamoylcholine (10 microM). Noradrenaline and carbamoylcholine responses were decreased to 27% and 33% respectively in the absence of extracellular Ca2+, suggesting a major requirement for Ca2+ entry. beta-Adrenergic stimulation elicited a small (35-40 nM) free Ca2+ rise, approx. 75% of which was mobilized from an intracellular store. Results suggest that this Ca2+ rise is a key event in the physiological triggering of mucin secretion by exocytosis.
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Childs, Michelle, Tiffany Blanchflower, Songyee Hur und Delisia Matthews. „Non-traditional marketplaces in the retail apocalypse: investigating consumers' buying behaviours“. International Journal of Retail & Distribution Management 48, Nr. 3 (23.02.2020): 262–86. http://dx.doi.org/10.1108/ijrdm-03-2019-0079.
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PurposeRevolutionary changes are happening in retail, and the term “retail apocalypse” reflects these dramatic changes. As a growing number of traditional brick-and-motor retailers are closing, the aim of this study is to understand and test the dimensions of specific store and consumer factors that are driving this shift towards non-traditional retail marketplaces (e.g. pop-up stores, fashion trucks), factors that drive consumer loyalty (i.e. re-patronage intentions) and the mediating role of shopping enjoyment in this context.Design/methodology/approachThis study used a consumer panel (n = 237) of previous shoppers of non-traditional retailers. Utilising exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), this study identifies possible store and consumer factors that are associated with consumers' patronage of non-traditional retailers. Based on results, we propose a model for non-traditional retail shopping behaviour.FindingsEFA revealed that quality of personal experience and consumer curiosity were dominant factors explaining variance. Key findings revealed that in-store factors (in-store ambiance, quality and value of products) and consumer factors (consumer curiosity, quality consciousness) influence consumers' re-patronage intentions. This highlights the importance of maintaining quality elements in shopping experiences. Shopping enjoyment was found to mediate relationships, indicating that while not all factors directly impact loyalty, it can be enhanced through pleasurable shopping experiences.Practical implicationsOur findings help retailers understand which factors are driving this dramatic change in consumer behaviour so they may develop better strategies to attract and retain customers. Retailers need to highlight product quality and in-store atmosphere and spark consumers' quality consciousness and curiosity to enhance consumer loyalty.Originality/valueDespite the rise in popularity, this is the first study to investigate non-traditional retailers comprehensively.
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Bahroni, Imam, und Hanief Karsa Manggala. „PENGARUH BRAND IMAGE TERHADAP PURCHASE INTENTION MELALUI E-TRUST (STUDI PADA CALON KONSUMEN ONLINE STORE HOODIEKU)“. ECOBISMA (JURNAL EKONOMI, BISNIS DAN MANAJEMEN) 10, Nr. 2 (03.07.2023): 146–56. http://dx.doi.org/10.36987/ecobi.v10i2.4528.
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In this day and age you can find many shops selling their products through internet media, one of the many products that are sold online is clothing or fashion products. Along with the rise of online stores circulating on the internet, potential consumers must be more confident in choosing products fashion, not all brands and online stores have a good reputation and are trusted, therefore to avoid a series of risks that can occur in online transactions, consumers will tend to seek as much information as possible about the brands and online stores they will choose before making a purchase. This study aims to determine the effect of Brand Image on Purchase Intentions through the online store of potential E-Trust Hoodieku customers. This research is a quantitative research using a descriptive and explanatory research design. The population taken in this study was the Instagram Official Store Hoodieku followers. The samples taken in this study were 205 respondents. The analysis technique uses descriptive statistical analysis and Partial Least Square (PLS) analysis. The results of the PLS test show that: (1) There is a positive and significant direct effect of Brand Image on E-Trust; (2) There is a positive and significant direct effect of E-Trust on Purchase Intentions; (3) There is a positive and significant indirect effect of Brand Image on Purchase Intention through E-Trust as a mediating variable.
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Ham, Sunny, Kai-Sean Lee, Bonhak Koo, Seoyoung Kim, Hyeyoung Moon und Heesup Han. „The rise of the grocerant: Patrons’ in-store dining experiences and consumption behaviors at grocery retail stores“. Journal of Retailing and Consumer Services 62 (September 2021): 102614. http://dx.doi.org/10.1016/j.jretconser.2021.102614.
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Marchetti, Carla. „Calcium signaling in prostate cancer cells of increasing malignancy“. Biomolecular Concepts 13, Nr. 1 (01.01.2022): 156–63. http://dx.doi.org/10.1515/bmc-2022-0012.
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Abstract Calcium signaling controls a large variety of cell functions, including proliferation and apoptosis, and plays a major role in neoplastic transformation. Prostate cancer (PCa) is one of the most common malignancies in men. The transition to castration-resistant prostate cancer (CRPC), a lethal form that is still lacking an effective cure, could be influenced by fine tuning intracellular calcium ([Ca2+]i) homeostasis. This study investigates [Ca2+]i dynamics in metastatic PCa cell lines that mimic the progression of PCa to CRPC: (i) well differentiated LNCaP cells that require androgen for survival, and (ii) poorly differentiated, highly aggressive androgen-insensitive prostate cancer (AIPC) PC3 and DU145 cells. In AIPC cells, ATP induces a fast rise in [Ca2+]i, due to release from intracellular stores and sensitive to phospholipase C inhibitors, while LNCaP cells do not respond to ATP challenge. Moreover, AIPC cells showed a reduced capacity to store Ca2+ in thapsigargin-sensitive stores and limited store-operated calcium entry, with respect to androgen-dependent LNCaP cells. Finally, green tea extract causes [Ca2+]i elevation and inhibits proliferation in PC3 and DU145 cells, but is ineffective in LNCaP cells. The consequences of these differences are discussed and interpreted in this study with reference to previously proposed models for Ca2+ dependence of prostate carcinogenesis.
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Oh, Jinseok, und Howard Kahm. „Selling Smiles: Emotional Labor and Labor-Management Relations in 1930s Colonial Korean Department Stores“. Journal of Korean Studies 23, Nr. 1 (01.03.2018): 3–24. http://dx.doi.org/10.1215/21581665-4339044.
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Abstract Department stores were the most luxurious retail institutions in colonial Korea in terms of their architecture, interior design, and product offerings. While Korean department stores closely resembled their Western and Japanese counterparts in form and function, the Korean department stores were unique for their position in developing retail practices and policies within a colonial context. Specifically, department stores hired young female workers to provide emotional labor to both customers and managers, which illustrated the transition from precapitalist to capitalist modes of emotional labor. Furthermore, the creation of a corporate culture and employee training programs that demanded a specific type of emotional labor resulted in various reactions from the employees, including complaints, criminal acts and violence, and the rise of class and political consciousness. Consequently, the evolution of labor-management relations in 1930s Korean department stores offers a gendered perspective on the economic and cultural aspects of Japanese control over life on the Korean peninsula, particularly through the bottom-up view of female department store workers.