Thematische Bibliographien / Stimulations gamma

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Auswahl der wissenschaftlichen Literatur zum Thema „Stimulations gamma“

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Veröffentlicht am 22. Februar 2025

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Zeitschriftenartikel zum Thema "Stimulations gamma"

Zhang, Jianing, Yanhuan Huang, Fuqiang Ye, Bibo Yang, Zengyong Li und Xiaoling Hu. „Evaluation of Post-Stroke Impairment in Fine Tactile Sensation by Electroencephalography (EEG)-Based Machine Learning“. Applied Sciences 12, Nr. 9 (09.05.2022): 4796. http://dx.doi.org/10.3390/app12094796.

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Electroencephalography (EEG)-based measurements of fine tactile sensation produce large amounts of data, with high costs for manual evaluation. In this study, an EEG-based machine-learning (ML) model with support vector machine (SVM) was established to automatically evaluate post-stroke impairments in fine tactile sensation. Stroke survivors (n = 12, stroke group) and unimpaired participants (n = 15, control group) received stimulations with cotton, nylon, and wool fabrics to the different upper limbs of a stroke participant and the dominant side of the control. The average and maximal values of relative spectral power (RSP) of EEG in the stimulations were used as the inputs to the SVM-ML model, which was first optimized for classification accuracies for different limb sides through hyperparameter selection (γ, C) in radial basis function (RBF) kernel and cross-validation during cotton stimulation. Model generalization was investigated by comparing accuracies during stimulations with different fabrics to different limbs. The highest accuracies were achieved with (γ = 21, C = 23) for the RBF kernel (76.8%) and six-fold cross-validation (75.4%), respectively, in the gamma band for cotton stimulation; these were selected as optimal parameters for the SVM-ML model. In model generalization, significant differences in the post-stroke fabric stimulation accuracies were shifted to higher (beta/gamma) bands. The EEG-based SVM-ML model generated results similar to manual evaluation of cortical responses to fabric stimulations; this may aid automatic assessments of post-stroke fine tactile sensations.

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Suzuki, M., T. Asplund, H. Yamashita, C. H. Heldin und P. Heldin. „Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-β1 involves activation of protein kinase C“. Biochemical Journal 307, Nr. 3 (01.05.1995): 817–21. http://dx.doi.org/10.1042/bj3070817.

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The intracellular signal transduction pathways that mediate the stimulatory effects of platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-beta on hyaluronan biosynthesis in human fibroblasts were investigated. The stimulatory effects of both PDGF-BB and TGF-beta 1 were dependent on protein kinase C (PKC), since the PKC inhibitor calphostin C inhibited the stimulation by the growth factors. Direct activation of PKC by phorbol 12-myristate 13-acetate (PMA) also stimulated hyaluronan production, and the combination of either PDGF-BB or TGF-beta 1 and PMA gave an increased effect. One possible mechanism for activation of PKC is via induction of phospholipase C (PLC) activity; U-17322, an inhibitor of PLC-gamma, was found to inhibit partially PDGF-BB-stimulated hyaluronan synthesis. PDGF-BB is known to activate PLC-gamma through tyrosine phosphorylation; however, a PDGF beta-receptor mutant unable to interact with and activate PLC-gamma was still able to mediate induction of hyaluronan biosynthesis, indicating that PDGF-mediated stimulation is not entirely dependent on PLC-gamma. The stimulations by PDGF-BB and TGF-beta 1 were partly dependent on protein synthesis, since parts of the effects were inhibited by cycloheximide; in contrast, the effects mediated by PMA were not. Our results indicate that PKC is involved in the transduction of the effects of growth factors on hyaluronan biosynthesis, and that the effects involve direct or indirect activation of existing hyaluronan synthetase molecules, as well as induction of new enzyme molecules.

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Hui, C. S., und W. Chen. „Effects of conditioning depolarization and repetitive stimulation on Q beta and Q gamma charge components in frog cut twitch fibers.“ Journal of General Physiology 99, Nr. 6 (01.06.1992): 1017–43. http://dx.doi.org/10.1085/jgp.99.6.1017.

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Charge movement was measured in frog cut twitch fibers with the double Vaseline-gap technique. Steady-state inactivation of charge movement was studied by changing the holding potential from -90 mV to a level ranging from -70 to -30 mV. Q beta and Q gamma at each holding potential were separated by fitting the Q-V plot with a sum of two Boltzmann distribution functions. At -70 mV Q beta and Q gamma were inactivated to 54.0% (SEM 2.2) and 82.7% (SEM 3.0) of the amounts at -90 mV. At holding potentials greater than or equal to -60 mV, more Q gamma was inactivated than Q beta, and at -30 mV Q gamma was completely inactivated but Q beta was not. There was no holding potential at which Q beta was unaffected and Q gamma was completely inactivated. The differences between the residual fractions of Q beta and Q gamma are significant at all holding potentials (P less than 0.001-0.05). The plot of the residual fraction of Q beta or Q gamma versus holding potential can be fitted well by an inverted sigmoidal curve that is a mirror image of the activation curve of the respective charge component. The pair of curves for Q gamma correlates well with those for tension generation or Ca release obtained by other investigators. The time courses of the inactivation of Q beta and Q gamma were studied by obtaining several Q-V plots with conditioning depolarizations lasting 1-20 s and separating each Q-V plot into Q beta and Q gamma components by fitting with a sum of two Boltzmann distribution functions. The inactivation time constant of Q beta was found to be 5-10 times as large as that of Q gamma. During repetitive stimulation, prominent I gamma humps could be observed in TEST-minus-CONTROL current traces and normal Q gamma components could be separated from the Q-V plots, whether 20 or 50 mM EGTA was present in the internal solution, whether 2 or 10 stimulations were used, and whether the stimuli were separated by 400 ms or 6 s. Repetitive stimulation slowed the kinetics of the I gamma hump and could shift the Q-V curve slightly in the depolarizing direction in some cases, resulting in an apparent suppression of charge at the potentials that fall on the steep part of the Q-V curve.

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Chen, Qi, Yue Dong und Yan Gai. „Tactile Location Perception Encoded by Gamma-Band Power“. Bioengineering 11, Nr. 4 (15.04.2024): 377. http://dx.doi.org/10.3390/bioengineering11040377.

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Background: The perception of tactile-stimulation locations is an important function of the human somatosensory system during body movements and its interactions with the surroundings. Previous psychophysical and neurophysiological studies have focused on spatial location perception of the upper body. In this study, we recorded single-trial electroencephalography (EEG) responses evoked by four vibrotactile stimulators placed on the buttocks and thighs while the human subject was sitting in a chair with a cushion. Methods: Briefly, 14 human subjects were instructed to sit in a chair for a duration of 1 h or 1 h and 45 min. Two types of cushions were tested with each subject: a foam cushion and an air-cell-based cushion dedicated for wheelchair users to alleviate tissue stress. Vibrotactile stimulations were applied to the sitting interface at the beginning and end of the sitting period. Somatosensory-evoked potentials were obtained using a 32-channel EEG. An artificial neural net was used to predict the tactile locations based on the evoked EEG power. Results: We found that single-trial beta (13–30 Hz) and gamma (30–50 Hz) waves can best predict the tactor locations with an accuracy of up to 65%. Female subjects showed the highest performances, while males’ sensitivity tended to degrade after the sitting period. A three-way ANOVA analysis indicated that the air-cell cushion maintained location sensitivity better than the foam cushion. Conclusion: Our finding shows that tactile location information is encoded in EEG responses and provides insights on the fundamental mechanisms of the tactile system, as well as applications in brain–computer interfaces that rely on tactile stimulation.

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İMDAT, Nuray Nükhet, Özlem Tuğçe ÇİLİNGİR-KAYA, Zehra Nur TURGAN ÂŞIK, Tuğba KARAMAHMUTOĞLU, Medine GÜLÇEBİ İDRİZ OĞLU, Dilek AKAKIN, Filiz ONAT und Serap ŞİRVANCI. „Electron microscopic GABA evaluation in hippocampal mossy terminals of genetic absence epilepsy rats receiving kindling stimulations“. Clinical and Experimental Health Sciences 12, Nr. 4 (30.12.2022): 981–87. http://dx.doi.org/10.33808/clinexphealthsci.1030132.

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Objective: The hypotheses related to the fact of epileptic mechanisms are mainly based on excitation-inhibition imbalance in central nervous system. GAERS (Genetic Absence Epilepsy Rats from Strasbourg) is a well-known animal model of absence epilepsy, and frequently used in experimental studies. In the present study, we aimed to examine possible morphological and gamma-aminobutyric acid (GABA) density changes in GAERS hippocampus after electrical kindling stimulations. Methods: All control and test group rats received 6 kindling stimulations. Rats were decapitated 1 h after the last stimulation. Ultrastructural GABA immunocytochemistry was used to evaluate GABA density quantitatively in mossy terminals of hippocampal CA3 region. Results: GABA levels were less in kindling groups compared to their controls, and in GAERS groups compared to Wistar groups; mitochondrial and dendritic spine area ratios were greater in GAERS groups compared to Wistar groups, although all these evaluations were statistically nonsignificant. Depletion of synaptic vesicles was evident in the mossy terminals of kindling groups. Conclusion: The reason of decreased levels of GABA found in the present study might be that GABA has been released from the synaptic pool rapidly at an early time period after the last stimulation, for compansation mechanisms. Depletion of synaptic vesicles observed in kindling groups shows that even 6 kindling stimulations have an impact of changing hippocampal morphology in trisynaptic cycle. The increased mitochondrial area in GAERS might be related to the increased mitochondrial activity. The increased dendritic spine area might be related to the increased performance of learning in GAERS. Our findings indicating that absence epilepsy and temporal lobe epilepsy have different mechanisms of epileptogenesis might be a basis for further experimental studies

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Schoisswohl, Stefan, Berthold Langguth, Tobias Hebel, Mohamed A. Abdelnaim, Gregor Volberg und Martin Schecklmann. „Heading for Personalized rTMS in Tinnitus: Reliability of Individualized Stimulation Protocols in Behavioral and Electrophysiological Responses“. Journal of Personalized Medicine 11, Nr. 6 (09.06.2021): 536. http://dx.doi.org/10.3390/jpm11060536.

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Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation tool potentially modulating pathological brain activity. Its clinical effectiveness is hampered by varying results and characterized by inter-individual variability in treatment responses. RTMS individualization might constitute a useful strategy to overcome this variability. A precondition for this approach would be that repeatedly applied protocols result in reliable effects. The condition tinnitus provides the advantage of immediate behavioral consequences (tinnitus loudness changes) after interventions and thus offers an excellent model to exemplify TMS personalization. Objective: The aim was to investigate the test–retest reliability of short rTMS stimulations in modifying tinnitus loudness and oscillatory brain activity as well as to examine the feasibility of rTMS individualization in tinnitus. Methods: Three short verum (1, 10, 20 Hz; 200 pulses) and one sham (0.1 Hz; 20 pulses) rTMS protocol were administered on two different days in 22 tinnitus patients. Before and after each protocol, oscillatory brain activity was recorded with electroencephalography (EEG), together with behavioral tinnitus loudness ratings. RTMS individualization was executed on the basis of behavioral and electrophysiological responses. Stimulation responders were identified via consistent sham-superior increases in tinnitus loudness (behavioral responders) and alpha power increases or gamma power decreases (alpha responders/gamma responders) in accordance with the prevalent neurophysiological models for tinnitus. Results: It was feasible to identify individualized rTMS protocols featuring reliable tinnitus loudness changes (55% behavioral responder), alpha increases (91% alpha responder) and gamma decreases (100% gamma responder), respectively. Alpha responses primary occurred over parieto-occipital areas, whereas gamma responses mainly appeared over frontal regions. On the contrary, test–retest correlation analyses per protocol at a group level were not significant neither for behavioral nor for electrophysiological effects. No associations between behavioral and EEG responses were found. Conclusion: RTMS individualization via behavioral and electrophysiological data in tinnitus can be considered as a feasible approach to overcome low reliability at the group level. The present results open the discussion favoring personalization utilizing neurophysiological markers rather than behavioral responses. These insights are not only useful for the rTMS treatment of tinnitus but also for neuromodulation interventions in other pathologies, as our results suggest that the individualization of stimulation protocols is feasible despite absent group-level reliability.

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Hwang, Eun Jung, und Richard A. Andersen. „Effects of visual stimulation on LFPs, spikes, and LFP-spike relations in PRR“. Journal of Neurophysiology 105, Nr. 4 (April 2011): 1850–60. http://dx.doi.org/10.1152/jn.00802.2010.

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Local field potentials (LFPs) have shown diverse relations to the spikes across different brain areas and stimulus features, suggesting that LFP-spike relationships are highly specific to the underlying connectivity of a local network. If so, the LFP-spike relationship may vary even within one brain area under the same task condition if neurons have heterogeneous connectivity with the active input sources during the task. Here, we tested this hypothesis in the parietal reach region (PRR), which includes two distinct classes of motor goal planning neurons with different connectivity to the visual input, i.e., visuomotor neurons receive stronger visual input than motor neurons. We predicted that the visual stimulation would render both the spike response and the LFP-spike relationship different between the two neuronal subpopulations. Thus we examined how visual stimulations affect spikes, LFPs, and LFP-spike relationships in PRR by comparing their planning (delay) period activity between two conditions: with or without a visual stimulus at the reach target. Neurons were classified as visuomotor if the visual stimulation increased their firing rate, or as motor otherwise. We found that the visual stimulation increased LFP power in gamma bands >40 Hz for both classes. Moreover, confirming our prediction, the correlation between the LFP gamma power and the firing rate became higher for the visuomotor than motor neurons in the presence of visual stimulation. We conclude that LFPs vary with the stimulation condition and that the LFP-spike relationship depends on a given neuron's connectivity to the dominant input sources in a particular stimulation condition.

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Sudha Kumari, Lekshmy, und Abbas Z. Kouzani. „A Miniaturized Closed-Loop Optogenetic Brain Stimulation Device“. Electronics 11, Nr. 10 (17.05.2022): 1591. http://dx.doi.org/10.3390/electronics11101591.

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This paper presents a tetherless and miniaturized closed-loop optogenetic brain stimulation device, designed as a back mountable device for laboratory mice. The device has the ability to sense the biomarkers corresponding to major depressive disorder (MDD) from local field potential (LFP), and produces a feedback signal to control the closed-loop operation after on-device processing of the sensed signals. MDD is a chronic neurological disorder and there are still many unanswered questions about the underlying neurological mechanisms behind its occurrence. Along with other brain stimulation paradigms, optogenetics has recently proved effective in the study of MDD. Most of these experiments have used tethered and connected devices. However, the use of tethered devices in optogenetic brain stimulation experiments has the drawback of hindering the free movement of the laboratory animal subjects undergoing stimulation. To address this issue, the proposed device is small, light-weight, untethered, and back-mountable. The device consists of: (i) an optrode which houses an electrode for collecting neural signals, an optical source for delivering light stimulations, and a temperature sensor for monitoring the temperature increase at the stimulation site, (ii) a neural sensor for acquisition and pre-processing of the neural signals to obtain LFP signals in the frequency range of 4 to 200 Hz, as electrophysiological biomarkers of MDD (iii) a classifier for classification of the signal into four classes: normal, abnormal alpha, abnormal theta, and abnormal gamma oscillations, (iv) a control algorithm to select stimulation parameters based on the input class, and (v) a stimulator for generating light stimulations. The design, implementation, and evaluation of the device are presented, and the results are discussed. The neural sensor and the stimulator are circular in shape with a radius of 8 mm. Pre-recorded neural signals from the mouse hippocampus are used for the evaluation of the device.

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Farrar, WL, und A. Harel-Bellan. „Myeloid growth factor(s) regulation of ornithine decarboxylase: effects of antiproliferative signals interferon-gamma and cAMP“. Blood 73, Nr. 6 (01.05.1989): 1468–75. http://dx.doi.org/10.1182/blood.v73.6.1468.1468.

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Abstract Colony-stimulating factors (CSFs) stimulate the activation and steady- state mRNA accumulation of an important regulatory enzyme for macromolecular synthesis, ornithine decarboxylase (ODC). Cloned murine CSF-dependent cell lines exhibited a rapid activation of ODC enzyme activity, detectable within ten minutes of stimulations with either interleukin-3 (IL-3), GM-CSF, or G-CSF. This early phase of enzyme activation did not require early protein or mRNA synthesis. The subsequent protracted rise in ODC activity occurring four to six hours after CSF treatment was dependent on increases in steady-state ODC mRNA accumulation and de novo protein synthesis. CSF, therefore, modulates both posttranslational activation of preexisting ODC and stabilization and accumulation of ODC mRNA. Antiproliferative signals, such as cAMP or interferon-gamma (IFN-gamma), effectively inhibited the CSF-directed increase in steady-state ODC mRNA. Cotreatment of the murine NSF 60.8 cell line with IFN-gamma and GM-CSF decreased steady-state ODC mRNA greater than 80% as compared with GM-CSF-treated cells alone. IFN treatment did not cause any appreciable destabilization of mature ODC mRNA, suggesting that its major effect may be at the level of ODC mRNA transcription or posttranscriptional processing. These data indicate that the ODC gene-protein system is an important molecular locus of the effects of myeloid proliferative and antiproliferation signals.

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Colony-stimulating factors (CSFs) stimulate the activation and steady- state mRNA accumulation of an important regulatory enzyme for macromolecular synthesis, ornithine decarboxylase (ODC). Cloned murine CSF-dependent cell lines exhibited a rapid activation of ODC enzyme activity, detectable within ten minutes of stimulations with either interleukin-3 (IL-3), GM-CSF, or G-CSF. This early phase of enzyme activation did not require early protein or mRNA synthesis. The subsequent protracted rise in ODC activity occurring four to six hours after CSF treatment was dependent on increases in steady-state ODC mRNA accumulation and de novo protein synthesis. CSF, therefore, modulates both posttranslational activation of preexisting ODC and stabilization and accumulation of ODC mRNA. Antiproliferative signals, such as cAMP or interferon-gamma (IFN-gamma), effectively inhibited the CSF-directed increase in steady-state ODC mRNA. Cotreatment of the murine NSF 60.8 cell line with IFN-gamma and GM-CSF decreased steady-state ODC mRNA greater than 80% as compared with GM-CSF-treated cells alone. IFN treatment did not cause any appreciable destabilization of mature ODC mRNA, suggesting that its major effect may be at the level of ODC mRNA transcription or posttranscriptional processing. These data indicate that the ODC gene-protein system is an important molecular locus of the effects of myeloid proliferative and antiproliferation signals.

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Dissertationen zum Thema "Stimulations gamma"

Kaminska, Anna. „Réponses corticales aux stimulations sensorielles étudiées par électroencéphalographie chez le nouveau-né de 30 semaines d'âge gestationnel jusqu'au terme“. Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB110.

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Les populations neuronales ont la capacité de s’organiser en réseaux qui produisent spontanément différents patterns d’activité électrique coordonnée. Au travers de leur activité synchrone, les réseaux immatures combinent les informations génétiques et les influences environnementales et contrôlent plusieurs processus neuro-développementaux dont la plasticité synaptique. Pendant le développement prénatal et post-natal précoce, ces activités électriques synchrones peuvent être générées au sein des cortex sensoriels eux-mêmes, des structures sous-corticales ou être évoquées par l’activité des organes sensoriels, elle-même spontanée ou provoquée par les stimuli sensoriels. Dans des travaux antérieurs, nous avons montré qu’un pattern EEG typique du prématuré, le « Delta-brush » (DB), qui associe une onde lente et des oscillations rapides, pouvait être évoqué dans les cortex primaires sensori-moteur, visuel et auditif par les mouvements spontanés et par les stimuli sensoriels correspondants. L’objectif de la présente étude, dédiée aux réponses corticales aux stimuli auditifs (click), était de préciser les caractéristiques spatio-temporelles des DBs évoqués ainsi que leur rapport avec des potentiels évoqués auditifs corticaux. Pour cela, les enregistrements EEG ont été réalisés en haute résolution (32 électrodes) chez 30 nouveau-nés prématurés de 30 à 38 semaines d’âge gestationnel sans risque neurologique et la position des électrodes a été recalée sur des IRM 3D acquises chez d’autres prématurés représentatifs des âges étudiés. L’analyse de population a montré une augmentation significative de la puissance spectrale après le stimulus dans toutes les bandes de fréquence allant du delta à gamma et située au niveau de la partie moyenne et postérieure du lobe temporal. Ces réponses du cortex temporal avaient une prédominance droite, étaient plus amples dans le sommeil calme et diminuaient en puissance avec l’âge. Le moyennage des réponses EEG a révélé que la composante lente du DB était une onde lente négative de grande amplitude qui culminait dans les régions temporales moyenne et postérieure à environ 550 et 700 ms respectivement. L’analyse temps-fréquence a confirmé la présence d’oscillations rapides dont les oscillations gamma, à partir du pic de l’onde lente et cohabitant avec cette dernière durant environ 700 ms. Ces résultats suggèrent que le DB évoqué par les stimuli auditifs correspond en fait à la composante lente tardive du potentiel évoqué auditif cortical du prématuré et qu’il regroupe des oscillations dans toutes les bandes de fréquence, gamma y compris, fréquence identifiée ici pour la première fois en réponse à un stimulus sensoriel chez le prématuré humain. Nous avons obtenu des résultats préliminaires similaires aussi dans une autre modalité sensorielle ; l’activité oscillatoire du DB évoqué contribue donc probablement à la maturation des cartes corticales et représente un biomarqueur potentiel du fonctionnement normal des cortex sensoriels chez le prématuré
At the early developmental stages, during the third trimester of gestation in humans and the first post-natal weeks in rodents, sensory neocortical areas reveal similar patterns of spontaneous correlated neuronal activity. In vitro and in vivo experiments indicate that these spontaneous activities are generated from neuronal networks in the cerebral cortex, in subcortical structures or in the sensory periphery (retina, limb jerks, whiskers). Spontaneous, periphery-driven and also sensory evoked activity is relayed to the developing cerebral cortex via the thalamus and the neocortical subplate, which amplifies the afferent sensory input. The patterns of sensory evoked activity were extensively studied in rodents, but in humans their spatiotemporal dynamics still remain elusive. In humans this developmental process happens during the second half of gestation: the major growing afferents from the thalamus spread within the transient subplate zone, relocate in the cortical plate, and form functional synapses with both transient and permanent neuronal populations. Characteristic immature activity patterns of “delta-brushes” (DBs) have been reported in the preterm temporal cortex following auditory stimuli. However, the spatiotemporal dynamics of these auditory-evoked DBs remain elusive. Here, we explored the electrophysiological responses evoked by click stimuli using 32-electrode EEG recordings in thirty premature infants from 30 to 38 postmenstrual weeks (PMW) of age. Electrodes position was digitalized and registered to 3D reconstructions of preterm heads and brains computed from MRI images of other age-matched groups. Population power spectrum analysis within the 2 seconds after stimulation revealed significant increase in all frequency bands from delta to gamma, located on the middle and posterior temporal regions with a right predominance and higher power increase in the quiet sleep. Time-frequency wavelet analysis also showed fast oscillations including gamma that begin at the peak of the delta waves and co-occur with it during a period of around 700 ms. Power of auditory evoked responses significantly decreased from 30 to 38 WPM in delta to alpha bands. These are the first report of gamma oscillations in preterm sensory evoked responses. Furthermore, average cortical auditory evoked potentials (CAEP) (processed with a mean reference and a 0.16 Hz high-pass filter) revealed high amplitude delta negative waves peaking successively from the middle to posterior temporal regions at around 550 and 700 ms. Altogether these results suggest that the auditory-evoked DBs in premature infants are a slow late component of the CAEP covering temporal regions and grouping fast oscillations notably gamma oscillations

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Aguilera, Matthieu. „The light at the end of the tunnel : study of early-stage brain dynamics alterations in Alzheimer’s disease and beneficial effects of light stimulation in the AppNL-F/MAPT mouse model“. Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ066.

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La maladie d’Alzheimer (MA), première cause de démence dans le monde, reste un défi majeur en raison de son diagnostic tardif et de l’absence de traitements efficaces. Alors que le diagnostic actuel repose sur la détection à travers des méthodes invasives de marqueurs pathologiques classiques tels que les plaques amyloïdes après l'apparition des symptômes cognitifs, de nombreuses études suggèrent que les changements pathologiques débutent des décennies avant ces manifestations cliniques. Le bon fonctionnement cérébral dépend d’une activité dynamique complexe, permettant des transitions flexibles entre différents réseaux fonctionnels. Ces dynamiques cérébrales, observables par EEG ou IRM fonctionnel, sont altérées dans plusieurs troubles neurologiques, dont la MA. Compte tenu de l’importance de la dynamique cérébrale pour les fonctions cognitives, une approche thérapeutique récente, appelée GENUS, utilise des stimulations sensorielles à 40 Hz pour moduler les oscillations neuronales. Cette approche a des effets prometteurs dans la MA malgré des mécanismes encore mal connus. En utilisant des enregistrements EEG haute densité dans un modèle préclinique de la MA, nous avons démontré des altérations de la dynamique cérébrale avant la formation des plaques amyloïdes, avec une fluidité réduite durant l’éveil associée à des déficits cognitifs subtils. Deux semaines de GENUS ont permis de restaurer à la fois les performances mnésiques et la dynamique cérébrale avant la formation des plaques amyloïdes, suggérant des bénéfices au-delà des effets du GENUS précédemment rapportés sur la pathologie amyloïde. Ce travail de thèse propose ainsi un outil de diagnostic précoce prometteur basé sur des mesures EEG non invasives, et démontre l’efficacité d’une intervention thérapeutique simple, facilement applicable en clinique, offrant de nouvelles perspectives pour la détection et le traitement précoces de la MA
Alzheimer's disease (AD), the leading cause of dementia worldwide, remains a major healthcare challenge due to late diagnosis and lack of effective treatments. While current diagnosis relies on invasive detection of classic amyloid and tau pathological hallmarks after cognitive symptoms appear, mounting evidence suggests that pathological changes begin decades before these clinical manifestations. Proper brain function depends on complex dynamic activity, allowing flexible transitions between different functional networks. These brain dynamics, assessable through EEG or functional MRI, are altered in various neurological conditions, including AD. Given their importance in cognitive function, a recent therapeutic approach called GENUS uses 40Hz sensory stimulation to modulate neural oscillations, showing promising effects in AD despite debated mechanisms. Using high-density EEG recordings in a preclinical AD mouse model, we demonstrated altered brain dynamics before amyloid plaque formation, showing reduced fluidity during wakefulness concurrent with subtle cognitive deficits. Two weeks of visual GENUS restored both memory performance and brain dynamics before amyloid plaque formation, suggesting benefits beyond previously reported effects on amyloid pathology. This thesis work presents both a promising early diagnostic tool based on non-invasive EEG measurements and demonstrates the efficacy of a simple therapeutic intervention readily implementable in clinical settings, offering new perspectives for early AD detection and treatment

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Martorell, Anthony J. Ph D. (Anthony James) Massachusetts Institute of Technology. „Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition“. Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/132749.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, June, 2019
Cataloged from the PDF version of thesis. Page 123 blank.
Includes bibliographical references (pages 115-122).
Changes in gamma activity (30-90 Hz) have been observed in humans and animal-models of Alzheimer's disease (AD). Examining the relationship between gamma oscillations and disease pathology is a significant problem in neuroscience. Recent work using a non-invasive light flicker at 40 Hz, termed Gamma ENtrainment Using Sensory stimulus, or 'GENUS', was shown to impact pathology in the visual cortex of AD-mouse models. However, it is not known whether other sensory modalities at 40 Hz can change pathology in higher order brain regions, or affect cognition, in AD-like animal models. In this thesis, I combine in vivo electrophysiology, biochemical and imaging techniques, and behavioral assays to understand the effects of multi-sensory gamma stimulation in AD-like animals. I first show that auditory tone stimulation at 40 Hz (auditory GENUS) can drive gamma frequency neural activity in auditory cortex (AC) and hippocampal CA1. I then demonstrate that seven days of auditory GENUS results in improved spatial and recognition memory and reduced amyloid load in AC and hippocampus of 5XFAD mice. These changes in activation responses were evident in microglia, astrocytes, and vasculature. Additionally, auditory GENUS reduced phosphorylated tau in the tau P301S model. Finally, I demonstrate that combined auditory and visual GENUS, but not either alone, decreases amyloid and produces a microglial-clustering response in the medial prefrontal cortex. Whole brain analysis using SHIELD processing revealed widespread reduction of amyloid plaques throughout neocortex after multi-sensory GENUS. These findings suggest that GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function.
by Anthony J. Martorell.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences

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Peng, Peijing. „Interaction of alpha-gamma-MSH analogues with MC1, MC3 and MC4 melanocortin receptors“. Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338413.

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Weigt, Henning. „Induktion einer TH1-Reaktion nach Stimulation von dendritischen Zellen mit MALP-2 und IFN-[gamma] [IFN-gamma] in einem In-vitro-Allergiemodell“. [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=96929235X.

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Goodwin, David G. „Age and Sex Related Behavioral Changes in Mice Congenitally Infected with Toxoplasma gondii: Role of dopamine and other neurotransmitters in the genesis of behavioral changes due to congenital infection and attempted amelioration with interferon gamma“. Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/28412.

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Evidence suggests that the neurotropic parasite Toxoplasma gondii may play a role in the development of cognitive impairments. My hypothesis was that congenital exposure to T. gondii would lead to detectable age and sex related differences in behavior and neurotransmitter levels in mice. The neurotransmitter dopamine and commonly used anti-schizophrenic agents were evaluated against T. gondii in human fibroblast cells. Dopamine caused a significant increase in tachyzoite numbers at 250 nM but not 100 nM and the drugs valproic acid, fluphenazine, thioridazine and trifluoperazine inhibited T. gondii development. The effects T. gondii infection had on behavior were examined using a congenital mouse model. Previous work demonstrated maternal immune stimulation (MIS) with interferon gamma (INF-g) resulted in decreased fetal mortality from congenital T. gondii infections; therefore I examined the effects of INF- g treatment of mothers to determine if protection from the behavioral effects of T. gondii occurred in their offspring. No differences in concentrations of neurotransmitters in the brains of congenitally infected mice were observed. I found that mice infected with T. gondii developed adult onset behavior impairments with decreased rate of learning, increased activity and decreased memory, indicating cognitive impairment for male mice and not female mice. My findings support the evidence T. gondii is a factor in the development of cognitive impairments. My results for T. gondii exposed male mice are consistent with the convention that males have more cognitive impairments in the prodromal stage of schizophrenia. MIS with IFN-g had a minimal effect on behavior post sexual maturity but had a greater effect on pre sexual maturity female mice which exhibited difficulties with spatial memory, coordination and the ability to process stimuli. The results indicate the behavior alterations from IFN- g are transient. When MIS is given prior to congenital infection with T. gondii, we detected no behavior deficits in any group of mice, including male mice post sexual maturity. Based on the results of my study, I must reject the hypothesis that neurotransmitter levels are influenced by congenital toxoplasmosis and accept the hypothesis that congenital T. gondii infection caused cognitive impairments in male mice post sexual maturity.
Ph. D.

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Anderson, Paul Michael. „Oscillations dans la bande de fréquence gamma dans des modèles de rongeurs pour la schizophrénie“. Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ025/document.

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La schizophrénie est un trouble mental débilitant qui se caractérise par des perturbations de la pensée, des émotions et de la cognition. Ces processus d’intégration fonctionnelle sont généralement associés à des oscillations bioélectriques cérébrales synchrones dans la bande de fréquence gamma (30-80 Hz), lesquelles sont aussi altérées chez des patients souffrant de schizophrénie. Ce travail de thèse vise à développer des méthodes et des outils pour étudier les mécanismes neuronaux sous-tendant les altérations de ces oscillations physiopathologiques. Pour ce faire, nous avons développé des modèles de rongeurs de laboratoire pour la schizophrénie. Nous avons démontré que des modifications génétiques ou pharmacologiques conduisent à des perturbations des oscillations gamma et que des médicaments antipsychotiques peuvent les moduler
Schizophrenia is a debilitating mental disorder that is characterised by a breakdown in normal thought processes, blunted emotional responses and a variety of cognitive difficulties. Gamma frequency (30 – 80 Hz) oscillations are associated with many processes that are disrupted in people with schizophrenia memory, perception and attention. This thesis aimed to develop methods and tools to investigate the basic mechanisms that underlie the alterations in gamma frequency brain activity that are observed in patients suffering from schizophrenia. To do this we developed a variety of experimental animal models for schizophrenia. We successfully demonstrated that both genetic and pharmacological changes lead to alterations in gamma oscillations and that antipsychotic medications can modulate them

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Cherouali, Toufik. „Caractérisation et implantation de la stimulation mécanique de la boucle neuromusculaire gamma sur une machine isocinétique“. Reims, 2004. http://theses.univ-reims.fr/exl-doc/GED00000049.pdf.

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Ce travail porte sur le développement d'une nouvelle méthode d'aide au renforcement musculaire et de son implantation sur une machine d'entraînement et de rééducation. A travers l'étude des boucles de régulation du muscle, nous avons montré qu'il est possible d'exciter volontairement la boucle neuromusculaire gamma en provoquant mécaniquement des étirements du muscle pendant sa contraction. La caractérisation des paramètres nécessaires à sa mise en œuvre pratique a été abordé à travers un modèle de simulation du muscle. Une spécification de tout les entraînements de la machine a été ensuite proposée pour intégrer la stimulation mécanique. Dans ce cadre un schéma de commande reposant sur une boucle de vitesse et sur un contrôleur en force a été proposé afin d'intégrer les profils de force de la stimulation. Une phase de validation expérimentale a permit d'illustrer une séance complète d'entraînement, de sa création à l'analyse des résultats et de valider les lois de commandes implantées
This work describes the characterization, implementation, and evaluation of mechanical stimulation with a view to enhancing muscular force by exploiting the effect of the neuromuscular gamma loop (NGL). After a study of the characteristics of muscle, a functional regulation diagram is proposed. Then, the specification and characterization of stimulation patterns allowed to identify the parameters required for the implementation on an isokinetic machine. After an adaptation of the control system of the machine, we have proposed a generic force based control scheme for Isokinetic machines. This controller carries out small movements used to stretch muscle, and this repeated stretching invokes the NGL during exercise. Some experimental results illustrate the efficiency of the proposed controllers and provide interesting results that can be easily exploited by the domain specialists to develop suitable training protocols using mechanical stimulation

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Schmidt, Oliver. „The effects of macrophage-stimulating protein and gamma synuclein on the development of brainstem motor systems“. Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/30728.

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Here, the effects of macrophage-stimulating protein (MSP) and γ-synuclein on two systems in the developing brainstem involved in controlling movement have been studied: a) the cranial motoneurons and b) the dopaminergic neurons of the substantia nigra and the ventral tegmental area. MSP exerts a variety of biological actions on many cell types, but has no known functions in the brain. To investigate whether MSP is also capable of acting as a neurotrophic factor, hypoglossal motoneurons were purified from the embryonic chicken hindbrain because these neurons are known to express the MSP receptor tyrosine kinase RON. The study shows that MSP promotes the in vitro survival of these neurons during the period of naturally occurring neuronal cell death and enhances the growth of neurites from these neurons. Furthermore, MSP mRNA was detected in the developing tongue which is the target tissue for hypoglossal neurons. These studies demonstrate that MSP is a neurotrophic factor for a distinct population of developing motoneurons. γ-synuclein is a recently discovered member of the synuclein family. Another member of this family, α-synuclein has been implicated in the pathogenesis of Parkinson’s disease. However, little is known about the function of γ-synuclein and it has not yet been directly implicated in the genesis of neurodegenerative conditions. Here, brainstems of transgenic mice lacking γ-synuclein have been analysed by means of immunohistochemical and histological techniques. The data obtained shows that γ-synuclein is expressed in the murine substantia nigra and in most cranial motor nuclei and that the localization of the protein undergoes a shift during development from a cytosomal to an axonal and synaptic localization. Mice lacking γ-synuclein have a deficit of neurons in these structures. In the context of recent studies which have revealed in vivo and in vitro interactions between the synucleins, this data suggests that a fine balance between α- and γ-synuclein seems critical to prevent the demise of certain neurons during the period of naturally occurring cell death. It also indicates that γ-synuclein may play a role in the pathogenesis of Parkinson’s disease.

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DeSantis, Dylan David. „CH3NH3PbBr3-xClx Device Characteristics for Gamma Spectroscopy with Simulations of Real Time Pulse Height Analysis“. The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1501878848404021.

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Bücher zum Thema "Stimulations gamma"

Enk, Alexander. Untersuchung über die Produktion von Interferon-[gamma] durch epidermale Langerhans-Zellen nach Stimulation. 1989.

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Wolters, Alexander, Ulf Ziemann und Reiner Benecke. The cortical silent period. Herausgegeben von Charles M. Epstein, Eric M. Wassermann und Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0010.

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The cortical silent period (cSP) refers to an interruption of voluntary muscle contraction by transcranial stimulation of the contralateral motor cortex. This article summarizes the physiology of cSP and gives guidelines as to how the cSP should be recorded and analysed, and refers to useful clinical applications. It describes the mechanisms at the spinal and supraspinal level can account for the cSP. It is currently thought that the cSP is mediated by gamma-aminobutyric acid receptors. cSP measurements are easy to obtain but require a standardized protocol to allow useful interpretation. Conditioning electrical stimulation of cutaneous nerves shortens the cSP. A conditioning transcranial magnetic stimulation pulse also affects cSP duration. The cSP duration is influenced by pathological conditions. cSP is an attractive probe to assess motor cortical inhibition in health and disease.

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Stamatelopoulou, Sophia-Isidora. [beta]-Adrenerge Stimulation der [gamma]-³²P-Azidoanilido-GTP Bindung an Gs und Gi/Go Proteine in menschlichen Herzmembranen. 2001.

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Müller, Sabine. Ethical challenges of modern psychiatric neurosurgery. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198786832.003.0013.

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Psychiatric neurosurgery is defined as neurosurgery for treating psychiatric disorders that do not have identified structural brain anomalies. Early psychiatric neurosurgery procedures such as lobotomy became discredited in the 1970s because of severe complications. After a nearly 30-year hiatus until the late 1990s, psychiatric neurosurgery experienced a revival. Today, modern psychiatric neurosurgery is more precise and safer than its historical predecessors. Deep brain stimulation has become an established treatment for treatment-refractory Parkinson’s disease, and has been tested in several hundreds of patients with different psychiatric disorders. Reports about its successful application have also stimulated the development and application of ablative psychiatric neurosurgery such as thermal or radiofrequency ablation, as well as Gamma Knife® radiosurgery and magnetic resonance-guided focused ultrasound. This chapter analyzes the pros and cons of a range of different existing and emerging psychiatric neurosurgical procedures and evaluates them ethically.

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Buchteile zum Thema "Stimulations gamma"

Geras'kin, Stanislav, Roman Churyukin, Polina Volkova und Sofiya Bitarishvili. „Using ionizing radiation for improving the development and yield of agricultural crops.“ In Mutation breeding, genetic diversity and crop adaptation to climate change, 424–32. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0043.

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Abstract The response of barley seedlings was studied after gamma irradiation of seeds with doses in the range of 2-50 Gy. It was shown that stimulation of plant growth occurred in the dose range of 16-20 Gy. The influences of the dose rate, the quality of seeds and their moisture on the manifestation of radiation effects were investigated. We studied, under controlled conditions, the activities of metabolic and antioxidant enzymes and observed an increase in their activity in the range of doses that cause stimulation of seedling growth. We showed that changes in the balance among different classes of phytohormones were probably involved in the acceleration of plant growth after irradiation of seeds using stimulating doses. Gamma irradiation of barley seeds significantly influenced the development of plants during the growing season. After irradiation with stimulating doses, we observed a reduction in the duration of the initial stages of ontogenesis; the phase of full ripeness occurred 5-7 days earlier than in the controls. The manifestation of the effect of irradiation depended on the conditions in which the plants developed. During the growing season of 2014, which was a dry year, plants originating from the irradiated seeds showed an increase in the number of productive stems, which led to an increase in yield by 34-38%; during the optimal 2015 season, an increase in the number of grains per spike caused an increase in yield by 8-29%. Therefore, our field study has shown that at least some hormetic effects can occur in the field. Irradiation of seeds can increase field germination, stimulate the growth and development of plants and increase their resistance to unfavourable environmental conditions. A more complete understanding of the underlying mechanisms of hormesis is needed to exploit its potential benefits in crop production.

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Scheepstra, K. A., E. Otten, M. Hulliger und R. W. Banks. „Modelling of Chaotic and Regular Ia Afferent Discharge During Fusimotor Stimulation“. In Alpha and Gamma Motor Systems, 325–27. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_69.

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Ingram, D. A., und D. N. Rushton. „The Site of Facilitation During Transcranial Double Pulse Magnetic Brain Stimulation in Man“. In Alpha and Gamma Motor Systems, 390–93. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_82.

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Banks, D. „Modulation of the Jaw-Opening Reflex Evoked by Tooth-Pulp Stimulation in the Cat“. In Alpha and Gamma Motor Systems, 412–14. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_89.

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Conway, B. A., D. T. Scott und J. S. Riddell. „The Effects of Plantar Nerve Stimulation on Long Latency Flexion Reflexes in the Acute Spinal Cat“. In Alpha and Gamma Motor Systems, 593–95. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_129.

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Boniface, S. J., K. R. Mills und M. Schubert. „Suppression of Single Spinal Motoneurones by Transcranial Magnetic Stimulation: Studies in Healthy Subjects, Multiple Sclerosis and Stroke“. In Alpha and Gamma Motor Systems, 516–18. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_111.

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Dickson, M., und M. H. Gladden. „Excitatory and Inhibitory Effects of Midbrain Stimulation on γS- and γD-Motoneurones of a Cat Hindlimb Muscle“. In Alpha and Gamma Motor Systems, 162–64. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_33.

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Mazzocchio, R., J. C. Rothwell und A. Rossi. „Depression of Recurrent Inhibition of the Soleus and Wrist Flexor Motor Nuclei by Magnetic Brain Stimulation in Humans“. In Alpha and Gamma Motor Systems, 514–15. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_110.

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Davey, N. J., P. H. Ellaway, D. W. Maskill und N. P. Anissimova. „The Basis of Variability in Magnitude of the Response of Muscles to Transcranial Magnetic Stimulation of the Motor Cortex in Man“. In Alpha and Gamma Motor Systems, 387–89. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_81.

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Simon, M., und J. Hunyadi. „Expression von OKM5 Antigen an humanen Keratinozyten in vitro nach Stimulation mit Gamma-Interferon“. In Dermatologie und Rheuma, 533–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72668-2_58.

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Konferenzberichte zum Thema "Stimulations gamma"

Lei, Xiyuan, Jiayang Xu, Anqi Wang, Nantu Hu, Shanbao Tong und Xiaoli Guo. „Gamma-band inter-brain synchrony during shared emotional stimulation in romantic relationship“. In 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 1–4. IEEE, 2024. https://doi.org/10.1109/embc53108.2024.10782266.

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Jiang, Yuxin, Pingxuan Shen, Yihao Yang, Ruiren Wu, Hongli Ma, Xiaoyu Tian, Zifan Luo, Wei Feng und Cong Wang. „A Device and Smartphone Application of Visual-Auditory Stimulation: Regulating Gamma Neural Oscillations for Motor Function Recovery After Stroke“. In 2024 17th International Convention on Rehabilitation Engineering and Assistive Technology (i-CREATe), 1–5. IEEE, 2024. https://doi.org/10.1109/i-create62067.2024.10776554.

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Yi, Ziwen, und Weijia Wang. „Brain entrainment by audio-visual gamma frequency stimulations“. In ICBBS 2022: 2022 11th International Conference on Bioinformatics and Biomedical Science. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3571532.3571551.

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Rivlin, L. A. „Inducing of Gamma-ray Emission without Overconcentration of Excited Oscillators by High Optical Field“. In High Resolution Fourier Transform Spectroscopy. Washington, D.C.: Optica Publishing Group, 1994. http://dx.doi.org/10.1364/hrfts.1994.mc3.

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Two separate self-consistent scenarios inherent in achieving induced emission of gamma-rays will be discussed. (A) The stimulation of annihilation of parapositronium atoms in colliding particle and photon beams by external infra-red radiation. It is known, that soft-photon stimulation of two-photon annihilation requires and inadmissible high particle energy (approx. 50 GeV). The new scenario consists of two positronium beams and two infrared photon beams moving in opposite directions and includes three steps : 1) exciting ls-2p transitions of moving relativistic positronium atoms (approx. 80 MeV) by an infrared beam (approx. 80 micrometer) propagating in the opposite direction ; 2) lasing in the beam of these excited atoms, the inversion being achieved as a result of lower-state cleansing due to spontaneous annihilation; and 3) stimulating the annihilation in the opposite positronium beam by Doppler shifted photons from the moving atomic laser realized in the previous step.

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Griffiths, Benjamin J., Daniel Weinert, Ole Jensen und Tobias Staudigl. „Gamma-band sensory stimulation enhances episodic memory retrieval“. In 2023 Conference on Cognitive Computational Neuroscience. Oxford, United Kingdom: Cognitive Computational Neuroscience, 2023. http://dx.doi.org/10.32470/ccn.2023.1321-0.

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Varner, Jerald L., und John W. Rohrbaugh. „Evoked EEG gamma band response at slow rates of stimulation“. In 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.5761542.

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Varner und Rohrbaugh. „Evoked Eeg Gamma Band Response At Slow Rates Of Stimulation“. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.592757.

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Pathak, Yagna, Oludamilola Salami, Sylvain Baillet, Zhimin Li und Christopher R. Butson. „Gamma power correlates with clinical response to repetitive transcranial magnetic stimulation (rTMS) for depression“. In 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2013. http://dx.doi.org/10.1109/ner.2013.6696043.

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Kunanbayev, Kassymzhomart, Jeongwon Lee und Dae-Shik Kim. „ROI-to-ROI fMRI Brain Functional Connectivity Analysis of Flickering Light Stimulation for Entraining Gamma Waves“. In 2023 Conference on Cognitive Computational Neuroscience. Oxford, United Kingdom: Cognitive Computational Neuroscience, 2023. http://dx.doi.org/10.32470/ccn.2023.1181-0.

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Martín, Lucía Inés, Denis Andre Marchal, Claudio Hugo Naides und Silvia Patricia Barredo. „Multi-Resolution Graph-Based Analysis for Fissility Evaluation in the Vaca Muerta Formation (Neuquén Basin, Argentina).“ In SPE Argentina Exploration and Production of Unconventional Resources Symposium. SPE, 2023. http://dx.doi.org/10.2118/212435-ms.

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Abstract Fine-grained rocks exposed at outcrops can remain massive or may split along relatively smooth surfaces parallel to the bedding when the rock is fissile. Fissility is an intrinsic structural characteristic of the rock revealed by weathering through the opening along weakness planes. Those weakness (or fissility) planes depend on numerous factors such as mineralogical composition, rock fabric, diagenetic processes and organic matter content and can exert an influence in the hydraulic stimulation of unconventional plays such as Vaca Muerta Formation. The fissility analysis performed on four cores encompassing more than 300 meters of the Vaca Muerta Formation results in a 4-class index, designated DAD (Drying Alcohol Discontinuities), that represent different fissility intensities. This information is related to the well log response of the cored rocks through a supervised classification using the MRGC (Multi-Resolution Graph-based Clustering) algorithm. This methodology allows considering multiple fissility controls simultaneously: gamma ray and photoelectric factor logs represent the mineralogical composition; sonic log as a proxy of geomechanical behavior; and the shallowest resistivity, representative of the texture of the rock. This classification reproduces potential fissility classes with a reasonable match on the four cores. To improve the accuracy of the resulting model, a high-resolution gamma ray curve is calculated from the processing of the microresistivity image. A second model is built replacing the raw gamma ray log with the HR-GR with an outstanding improvement, especially in the case of high fissility rock classes. Finally, the analysis is complemented with rock mechanics measurements coming from laboratory test to establish the effect of fissility on the geomechanical behavior of the rock.

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Berichte der Organisationen zum Thema "Stimulations gamma"

Shi, Y. E. Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma. Fort Belvoir, VA: Defense Technical Information Center, Juni 2005. http://dx.doi.org/10.21236/ada455854.

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Shi, Yuenian. Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Gamma Synuclein. Fort Belvoir, VA: Defense Technical Information Center, Juni 2009. http://dx.doi.org/10.21236/ada518447.

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Marleau, Peter, Aaron Nowack, Shaun Clarke, Mateusz Monterial, Marc Paff und Sara Pozzi. Gamma/neutron time-correlation for special nuclear material characterization %3CU%2B2013%3E active stimulation of highly enriched uranium. Office of Scientific and Technical Information (OSTI), September 2013. http://dx.doi.org/10.2172/1096490.

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