Zeitschriftenartikel: „Stent de déviation de flux“

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Guédon, A., E. Shotar, C. Thepenier, J. Gabrieli, C. Rolla-Bigliani, A. Nouet, V. Degos, N. Sourour und F. Clarençon. „Facteurs prédictifs d’occlusion anévrismale après pose d’un stent à diversion de flux“. Journal of Neuroradiology 45, Nr. 2 (März 2018): 72. http://dx.doi.org/10.1016/j.neurad.2017.12.007.

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Janot, Kevin, Robert Fahed, Aymeric Rouchaud, Kevin Zuber, Géraud Forestier, Charbel Mounayer und Michel Piotin. „Le redressement de l’artère induit par un stent à diversion de flux influence l’occlusion anévrismale“. Journal of Neuroradiology 46, Nr. 2 (März 2019): 69. http://dx.doi.org/10.1016/j.neurad.2019.01.063.

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Pivet, Sebastien, und Omer Eker. „TEMPORARY REMOVAL: REVUE DE LITTÉRATURE DES STENT À DIVERSION DE FLUX ET MODIFICATION DE SURFACE“. Journal of Neuroradiology 51, Nr. 2 (März 2024): 126. http://dx.doi.org/10.1016/j.neurad.2024.01.067.

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Birapadian, Shiivaa Manjare, Seng Fai Tang, Chenshen Lam und Norshamsiah Md Din. „Improvement of optic nerve head perfusion and reversible visual field defect following XEN Gel Stent implant“. Malaysian Journal of Ophthalmology 5, Nr. 1 (06.11.2023): 1–6. http://dx.doi.org/10.35119/myjo.v5i1.274.

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Background: Patients with juvenile onset ocular hypertension (OHT) have high intraocular pressure (IOP) and may develop early glaucomatous disc damage. Case presentation: A 26-year-old woman with family history of glaucoma was diagnosed with OHT at age 18. Her vision was 6/6, with a bilateral cup-to-disc ratio of 0.5, normal visual field (VF), and IOP in the mid-teens on 2 topical antiglaucoma medications. The patient started having IOP spikes (20–48 mmHg) in her left eye despite maximum tolerable medical therapy, associated with intermittent headache and nasal step defect on VF test. XEN Gel Stent was implanted and IOP reduced to 10–14 mmHg without medical therapy. Optical coherence tomography angiography showed improvement in optic nerve head (ONH) perfusion density and flux, while the VF defect disappeared. Conclusion: Improvement in ONH perfusion and reversibility of early glaucomatous VF defect is feasible with prompt XEN Gel Stent implant in juvenile OHT.

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Zhang, J., A. Hopkins, P. J. Barnes, M. Cagnes, Y. Yonekura und Y. Fukui. „The Radio-FIR Correlation in the Milky Way“. Publications of the Astronomical Society of Australia 27, Nr. 3 (2010): 340–46. http://dx.doi.org/10.1071/as08072.

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AbstractWe investigate the scale on which the correlation arises between the 843 MHz radio and the 60 μm far-infrared (FIR) emission from star forming regions in the Milky way. The correlation, which exists on the smallest scales investigated (down to ≈ 4 pc), becomes noticeably tight on fields of size 30′, corresponding to physical scales of ≈ 20–50 pc. The FIR to radio flux ratio on this scale is consi stent with the radio emission being dominated by thermal emission. We also investigate the location dependence of qmean, a parameter measuring the mean FIR to radio flux ratio, of a sample of star forming regions. We show that qmean displays a modest dependence on galactic latitude. If this is interpreted as a dependence on the intensity of star formation activity, the result is consistent with studies of the Large Magellanic Cloud (LMC) and other near by galaxies that show elevated values for q in regions of enhanced star formation.

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Papaxanthos, Jean, Federico Cagnazzo, François Louis Colmiche, Xavier Barreau, Florent Gariel, Jerome Berge, Cyril Dargazanli, Vincent Costalat und Gaultier Marnat. „Ticagrelor versus clopidogrel lors de l'embolisation d'anevrismes intra craniens non rompus par stent a diversion de flux“. Journal of Neuroradiology 49, Nr. 2 (März 2022): 117–18. http://dx.doi.org/10.1016/j.neurad.2022.01.015.

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Perdrix, Jean, Pascal Simon Heiniger und Thierry Fumeaux. „Maladie coronarienne stable et pose de stent : mesurer la réserve de flux coronarien pour mieux sélectionner les patients ?“ Revue Médicale Suisse 8, Nr. 354 (2012): 1797. http://dx.doi.org/10.53738/revmed.2012.8.354.1797.

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Tessier, Guillaume, Romain Bourcier, Benjamin Daumas-Duport und Hubert Desal. „Traitement endovasculaire des anévrysmes larges et géants de la carotide interne: occlusion carotidienne ou stent de diversion de flux ?“ Journal of Neuroradiology 49, Nr. 2 (März 2022): 139–40. http://dx.doi.org/10.1016/j.neurad.2022.01.043.

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Caroff, Jildaz, Anna Luisa Kühn, Katyucia De Macedo Rodrigues, David E. Rex, Robert M. King, Ajay K. Wakhloo, Miklos Marosfoi, Matthew J. Gounis und Ajit S. Puri. „L’angioplastie après la pose d’un stent à diversion de flux est une technique sûre pour améliorer les taux d’occlusion anévrismale“. Journal of Neuroradiology 46, Nr. 2 (März 2019): 68. http://dx.doi.org/10.1016/j.neurad.2019.01.061.

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Labeyrie, Paul-Emile, Benjamin Gory, Udi Sadeh-Gonike, Nazyed Huguet, Rotem Sivan-Hoffmann, Roberto Riva, Patrick Courthéoux und Francis Turjman. „Early angiographic changes of intra-aneurysmal flow after flow-diverter stent treatment are not predictive of therapeutic success“. Interventional Neuroradiology 22, Nr. 6 (20.08.2016): 682–86. http://dx.doi.org/10.1177/1591019916662192.

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Background and purpose Flow-diverter stents (FDS) are new devices for the endovascular treatment of intracranial aneurysms (IAs) promoting progressive aneurysmal thrombosis. To date, the delay of aneurysmal exclusion remains unclear. We evaluated the correlation between angiographic changes in the first 24 hours and 12-month occlusion in aneurysms treated with FDS. Methods We retrospectively analyzed the intra-aneurysmal flow by evaluating the in-flow and out-flow delays on preoperative, immediate postoperative, 24-hour and 12-month follow-up angiography. Dichotomy of in-flow and out-flow within the aneurysm was considered as the time of contrast filling and time of contrast washing relatively to the parent artery. The delay times were compared and correlated with the therapeutic success of FDS at 12 months of follow-up. Results Out of 14 treated IAs, in 13 consecutive patients, n = 10 (71%) aneurysms showed complete occlusion at 12 months. Between immediate postoperative and 24-hour control, 10 aneurysms (71%) demonstrated in-flow modification, with eight increasing, two decreasing and four having no change. There were no statistical differences in therapeutic success in relation to the different flow-related profiles of intra-aneurysmal flux. Out-flow modifications were found in 11 aneurysms (79%) between immediate postoperative and 24-hour control, with five increasing, six decreasing and three having no change. Similar to the in-flow changes, there were no statistical differences in therapeutic success relative to the flow-related profiles. Conclusions Early angiographic changes after FDS placement are very frequent, but are not correlated with the 12-month technical success of flow-diversion techniques.

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Crespy, Alexandre, Gregoire Boulouis, Héloïse Ifergan, Valère Barrot, Fakhreddine Boustia, Richard Bibi, Denis Herbreteau und Kévin Janot. „Efficacité et sécurité d'une double anti- agrégation par kardégic et ticagrelor pour le traitement par stent à diversion de flux des anévrismes de la circulation cérébrale postérieure“. Journal of Neuroradiology 49, Nr. 2 (März 2022): 144–45. http://dx.doi.org/10.1016/j.neurad.2022.01.049.

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Wang, Yun-Ting, Jiajie Chen, Xiang Li, Michihisa Umetani, Yang Chen, Pin-Lan Li und Yang Zhang. „Contribution of transcription factor EB to adipoRon-induced inhibition of arterial smooth muscle cell proliferation and migration“. American Journal of Physiology-Cell Physiology 317, Nr. 5 (01.11.2019): C1034—C1047. http://dx.doi.org/10.1152/ajpcell.00294.2019.

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Abnormal vascular smooth muscle cell (SMC) dedifferentiation with increased proliferation and migration during pathological vascular remodeling is associated with vascular disorders, such as atherosclerosis and in-stent restenosis. AdipoRon, a selective agonist of adiponectin receptor, has been shown to protect against vascular remodeling by preventing SMC dedifferentiation. However, the molecular mechanisms that mediate adipoRon-induced SMC differentiation are not well understood. The present study aimed to elucidate the role of transcription factor EB (TFEB), a master regulator of autophagy, in mediating adipoRon’s effect on SMCs. In cultured arterial SMCs, adipoRon dose-dependently increased TFEB activation, which is accompanied by upregulated transcription of genes involved in autophagy pathway and enhanced autophagic flux. In parallel, adipoRon suppressed serum-induced cell proliferation and caused cell cycle arrest. Moreover, adipoRon inhibited SMC migration as characterized by wound-healing retardation, F-actin reorganization, and matrix metalloproteinase-9 downregulation. These inhibitory effects of adipoRon on proliferation and migration were attenuated by TFEB gene silencing. Mechanistically, activation of TFEB by adipoRon is dependent on intracellular calcium, but it is not associated with changes in AMPK, ERK1/2, Akt, or molecular target of rapamycin complex 1 activation. Using ex vivo aortic explants, we demonstrated that adipoRon inhibited sprouts that had outgrown from aortic rings, whereas lentiviral TFEB shRNA transduction significantly reversed this effect of adipoRon on aortic rings. Taken together, our results indicate that adipoRon activates TFEB signaling that helps maintain the quiescent and differentiated status of arterial SMCs, preventing abnormal SMC dedifferentiation. This study provides novel mechanistic insights into understanding the therapeutic effects of adipoRon on TFEB signaling and pathological vascular remodeling.

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Barrot, Valere, Raoul Kanav Khanna, Sophie Catanese, Richard Bibi und Kevin Janot. „Visual flow: analyse des consequences ophtalmologiques du traitement d'un anevrisme carotidien par un stent a diversion de flux couvrant l'origine de l'artere ophtalmique chez des patients beneficiant d'une double antiagregation par aspirine et ticagrelor“. Journal of Neuroradiology 50, Nr. 2 (März 2023): 104–5. http://dx.doi.org/10.1016/j.neurad.2023.01.011.

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Zbili, Jordan, Quentin Alias, François Eugène, Jean-Yves Gauvrit und Jean-Christophe Ferré. „TEMPORARY REMOVAL: SUIVI D'ANÉVRISMES INTRACRÂNIENS TRAITÉS PAR STENT DE DIVERSION DE FLUX SILK VISTA BABY: COMPARAISON DE L'ARM PAR TEMPS DE VOL (3D-TOF) ET ARM AVEC INJECTION DE PRODUIT DE CONTRASTE (ARM-GADO)“. Journal of Neuroradiology 51, Nr. 2 (März 2024): 93. http://dx.doi.org/10.1016/j.neurad.2024.01.041.

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Desai, Mital, Rachel E. Clough, Nicholas R. Gaddum, Kawal Rhode, Xiang Zhou, Zhong You, Alexander M. Seifalian und George Hamilton. „Abstract 249: Stationary Signal and Flow Velocity Assessment by MRI of a New Nitinol Nanocomposite Polymer Stent-Graft“. Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (Mai 2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a249.

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Objective: To assess MRI compatibility and suitability of a new sutureless stent-graft made from Nitinol bonded to nanocomposite polymer (NP). Methods: 1. Using MRI and Magnevist contrast, isotropic 3D T1-weighted FFE images of NP stent-graft were acquired to observe artefacts and stationary signal attenuation. Average signal magnitude was calculated. Medtronic ValiantTM was used as control. 2. In second stage, steady flow phantom was setup for flow-encoded MRI signal assessment of both stent-grafts. Baseline values were obtained by velocity measurements without stent-graft using identical settings. 2D through-plane phase contrast images were acquired and average velocity and amount of flow (flux) were calculated. Results: On static assessment of NP and ValiantTM stent-grafts no significant image artefacts were seen. The signal inside and outside the ValiantTM stent-graft was 644.2(SD 36.2) and 659.6(SD 85.8) respectively. The signal attenuation for this device was 2.39%. The signal inside and outside the NP stent graft was 1561.7(SD 31.2) and 1595.5(SD 40.8) respectively with comparable signal attenuation of 2.16%. In MRI velocity attenuation study, steady flow phantom was set at mean volume of 105.3 ml and mean velocity of 79.5 cm/sec. Flux measured in ValiantTM stent-graft was 102±2.27 ml/sec with no significant difference to baseline (104±1.98 ml/sec; P=0.892). Similarly flux for NP stent-graft at mean stroke volume 104.4 ml and mean velocity of 92.3 cm/sec showed no difference to baseline (99.8±2.4 vs. 104±0.96 ml/sec; P=0.176). There was no significant difference in flux between Medtronic and NP stent-grafts (102±2.27 vs. 99.8±2.4 ml/sec; P=0.328). Conclusion: NP stent-graft does not display any material-induced artefacts on MRI. On flow assessment, signal attenuation is comparable with the commercial device. These properties are important in developing this stent-graft, compliant, durable, visco-elastic, biocompatible and anti-thrombogenic, for future clinical use.

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Heunis, Christoff M., Bruno Silva, Giulia Sereni, Martijn C. W. Lam, Besma Belakhal, Arold Gaborit, Bryan Wermelink, Bob R. H. Geelkerken und Sarthak Misra. „The Flux One Magnetic Navigation System: A Preliminary Assessment for Stent Implantation“. IEEE Robotics and Automation Letters, 2023, 1–8. http://dx.doi.org/10.1109/lra.2023.3289108.

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Selvarasu, N. K. C., Danesh K. Tafti und Pavlos P. Vlachos. „Hydrodynamic Effects of Compliance Mismatch in Stented Arteries“. Journal of Biomechanical Engineering 133, Nr. 2 (31.01.2011). http://dx.doi.org/10.1115/1.4003319.

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Cardiovascular diseases are the number one cause of death in the world, making the understanding of hemodynamics and development of treatment options imperative. The most common modality for treatment of occlusive coronary artery diseases is the use of stents. Stent design profoundly influences the postprocedural hemodynamic and solid mechanical environment of the stented artery. However, despite their wide acceptance, the incidence of stent late restenosis is still high (Zwart et al., 2010, “Coronary Stent Thrombosis in the Current Era: Challenges and Opportunities for Treatment,” Current Treatment Options in Cardiovascular Medicine, 12(1), pp. 46–57), and it is most prevailing at the proximal and distal ends of the stent. In this work, we focus our investigation on the localized hemodynamic effects of compliance mismatch due to the presence of a stent in an artery. The compliance mismatch in a stented artery is maximized at the proximal and distal ends of the stent. Hence, it is our objective to understand and reveal the mechanism by which changes in compliance contribute to the generation of nonphysiological wall shear stress (WSS). Such adverse hemodynamic conditions could have an effect on the onset of restenosis. Three-dimensional, spatiotemporally resolved computational fluid dynamics simulations of pulsatile flow with fluid-structure interaction were carried out for a simplified coronary artery with physiologically relevant flow parameters. A model with uniform elastic modulus is used as the baseline control case. In order to study the effect of compliance variation on local hemodynamics, this baseline model is compared with models where the elastic modulus was increased by two-, five-, and tenfold in the middle of the vessel. The simulations provided detailed information regarding the recirculation zone dynamics formed during flow reversals. The results suggest that discontinuities in compliance cause critical changes in local hemodynamics, namely, altering the local pressure and velocity gradients. The change in pressure gradient at the discontinuity was as high as 90%. The corresponding changes in WSS and oscillatory shear index calculated were 9% and 15%, respectively. We demonstrate that these changes are attributed to the physical mechanism associating the pressure gradient discontinuities to the production of vorticity (vorticity flux) due to the presence of the stent. The pressure gradient discontinuities and augmented vorticity flux are affecting the wall shear stresses. As a result, this work reveals how compliance variations act to modify the near wall hemodynamics of stented arteries.

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Selvarasu, N. K. C., und Danesh K. Tafti. „Effects of Elastic Modulus Change in Helical Tubes Under the Influence of Dynamic Changes in Curvature and Torsion“. Journal of Biomechanical Engineering 136, Nr. 8 (02.06.2014). http://dx.doi.org/10.1115/1.4027661.

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The incidence of stent late restenosis is high (Zwart et al., 2010, “Coronary Stent Thrombosis in the Current Era: Challenges and Opportunities for Treatment,” Curr. Treat. Options Cardiovasc. Med., 12(1), pp. 46–57) despite the extensive use of stents, and is most prevalent at the proximal and distal ends of the stent. Elastic modulus change in stented coronary arteries subject to the motion of the myocardium is not studied extensively. It is our objective to understand and reveal the mechanism by which changes in elastic modulus and geometry contribute to the generation of nonphysiological wall shear stress (WSS). Such adverse hemodynamic conditions could have an effect on the onset of restenosis. Three-dimensional (3D), spatiotemporally resolved computational fluid dynamics (CFD) simulations of pulsatile flow with moving wall boundaries and fluid structure interaction (FSI) were carried out for a helical artery with physiologically relevant flow parameters. To study the effect of coronary artery (CA) geometry change on stent elastic modulus mismatch, models where the curvature, torsion and both curvature and torsion change were examined. The elastic modulus is increased by a factor of two, five, and ten in the stented section for all three modes of motion. The changes in elastic modulus and arterial geometry cause critical variations in the local pressure and velocity gradients and secondary flow patterns. The pressure gradient change is 47%, with respect to the unstented baseline when the elastic modulus is increased to 10. The corresponding WSS change is 15.4%. We demonstrate that these changes are attributed to the production of vorticity (vorticity flux) caused by the wall movement and elastic modulus discontinuity. The changes in curvature dominate torsion changes in terms of the effects to local hemodynamics. The elastic modulus discontinuities along with the dynamic change in geometry affected the secondary flow patterns and vorticity flux, which in turn affects the WSS.

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Vijayaratnam, P. R. S., T. J. Barber und J. A. Reizes. „The Localized Hemodynamics of Drug-Eluting Stents Are Not Improved by the Presence of Magnetic Struts“. Journal of Biomechanical Engineering 139, Nr. 1 (30.11.2016). http://dx.doi.org/10.1115/1.4035263.

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The feasibility of implementing magnetic struts into drug-eluting stents (DESs) to mitigate the adverse hemodynamics which precipitate stent thrombosis is examined. These adverse hemodynamics include platelet-activating high wall shear stresses (WSS) and endothelial dysfunction-inducing low wall shear stresses. By magnetizing the stent struts, two forces are induced on the surrounding blood: (1) magnetization forces which reorient red blood cells to align with the magnetic field and (2) Lorentz forces which oppose the motion of the conducting fluid. The aim of this study was to investigate whether these forces can be used to locally alter blood flow in a manner that alleviates the thrombogenicity of stented vessels. Two-dimensional steady-state computational fluid dynamics (CFD) simulations were used to numerically model blood flow over a single magnetic drug-eluting stent strut with a square cross section. The effects of magnet orientation and magnetic flux density on the hemodynamics of the stented vessel were elucidated in vessels transporting oxygenated and deoxygenated blood. The simulations are compared in terms of the size of separated flow regions. The results indicate that unrealistically strong magnets would be required to achieve even modest hemodynamic improvements and that the magnetic strut concept is ill-suited to mitigate stent thrombosis.

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Bamahmud, Alaa, Mohamed El-Sherbiny, Roman Jednak, Karl Muchantef, Sharon Abish, David Mitchell, Catherine Vezina und Indra R. Gupta. „Case Report of Renal Calculi in a Child Receiving Imatinib for Acute Lymphoblastic Leukemia“. Canadian Journal of Kidney Health and Disease 10 (Januar 2023). http://dx.doi.org/10.1177/20543581231215849.

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Rationale: Imatinib is used in the treatment of Philadelphia chromosome positive (Ph+) leukemias and has been reported to have a direct effect on bone physiology. Presentation: To report on a child with Ph+ acute lymphoblastic leukemia who presented with bilateral flank pain and gross hematuria. Diagnosis: She was diagnosed with obstructive kidney stones 101 days after commencing daily oral imatinib. Stone analysis revealed the presence of calcium phosphate. Interventions and outcome: The patient passed the stones spontaneously with medical therapy that included the use of thiazide, allopurinol, and potassium citrate, but she required temporary insertion of a double-J stent to relieve an obstruction. Novel findings: Imatinib inhibits receptor tyrosine kinases and stimulates the flux of calcium from the extracellular fluid into bone, resulting in hypocalcemia with a compensatory rise in parathyroid hormone that may result in phosphaturia and the formation of calcium phosphate stones. Given that kidney stones are rare events in children, we believe that monitoring for kidney stone formation needs to be performed in children receiving imatinib.

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Sarifuddin und Prashanta Kumar Mandal. „Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy“. Scientific Reports 14, Nr. 1 (22.02.2024). http://dx.doi.org/10.1038/s41598-024-54756-9.

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AbstractDrug-coated balloon (DCB) angioplasty is one of the potential approaches to alleviating in-stent restenosis and treating peripheral artery disease. An in-silico model has been developed for sirolimus drug eluted from an inflated balloon in a patient-specific arterial cross-section consisting of fibrous tissue, fibrofatty tissue, dense calcium, necrotic core, and healthy tissue. The convection-diffusion-reaction equation represents the transport of drug, while drug binding, both specific and non-specific, can be modelled as a reaction process. The Brinkman equations describe the interstitial flow in porous tissue. An image processing technique is leveraged for reconstructing the computational domain. The Marker and Cell, and Immersed Boundary Methods are used to solve the set of governing equations. The no-flux interface condition and convection do amplify the tissue content, and the regions of dense calcium and necrotic core limited to or extremely close to the interface pose a clinical threat to DCB therapy. Simulations predict the effects of the positioning and clustering of plaque components in the domain. This study demands extensive intravascular ultrasound-derived virtual histology (VH-IVUS) imaging to understand the plaque morphology and determine the relative positions of different plaque compositions about the lumen-tissue interface, which have a significant impact on arterial pharmacokinetics.

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