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1
Krejčík, Jan. „Funkce Sinumeriku Operate při programování CNC obráběcích strojů“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-444266.
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The diploma thesis is focused on possibilities of spline approximation and interpolation of CAD imported by CAD Reader to control system. First chapter describes mathematical meaning of curves, the second chapter shows possibilities of approximation and interpolation in control system Sinumerik 840D and the third chapter applies these possibilities on practical example.
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Škvarenina, Ľubomír. „Interpolace signálů pomocí NURBS křivek“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220618.
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Diploma thesis deals with image interpolation. The aim of this work is to study theoretically and then describe the nature of the various methods of image interpolation and some of them implemented in the program MATLAB. The introductory part of this work theoretically closer to important terms that are closely related to this topic of digital image processing sufficient to understand the principle. In the following of the thesis will be discussed all of today's commonly used method of image interpolation. Will hear all about the method of image interpolation using nearest neightbor interpolation and image help of polynimals such as (bi)linear, (bi)quadratic and (bi)kubic method. Then work theoretically analyzes the theory of individual species curves and splines. More specifically, coming to their most frequently used variants of B-spline curves and ther generalizations called NURBS, with addressing the problem of interpolating these curves. The final chapter consists of the results achieved in the program MATLAB.
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Ondroušková, Jana. „Modelování NURBS křivek a ploch v projektivním prostoru“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2009. http://www.nusl.cz/ntk/nusl-228872.
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In the first part I discuss ancestors of NURBS curves and surfaces, rather Ferguson, Beziere, Coons and B-spline curves and surfaces and furthermore B-spline functions. In the second part I devote to NURBS curves and surfaces, their description as a linear combination of B-spline functions in the projective space. I specify conical arcs more detailed, their submit in the projective space and NURBS surfasec given as tensor product of NURBS curves. Last part is devote to describtion programs for modeling conicals and NURBS surface.
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Novák, Jiří. „Metody FFD“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318794.
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The diploma thesis deals with the topic of free-form deformations. The main goal of this work were elaboration of theoretical knowledge about this issue and the programming of selected methods od free-form deformations. The first part describes the required spline theory, matrix calculus and free-form deformations. The resulting version shows three programs. The first program compares the selected free-form deformation methods to the example of the 4x4 control point grid. The second program serves as a generalization for the general case of grid of control points. The last program is based on direct manipulation of arbitrary surface point and following recomputation of the control points to obtain demanded shape.
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Franěk, Pavel. „Analýza variability srdečního rytmu pomocí rekurentního diagramu“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220048.
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The aim of this thesis is to describe the variability of cardiac rhythm and familiarity with the methods of the analysis, ie by monitoring changes in heart rhythm electrogram signal recording and using the methods in the time domain using recurrent diagram. The work describes the quantification of the methods and possibilities of quantifiers in the evaluation of heart rate variability analysis. It also describes the clinical significance of heart rate variability and diagnostic capabilities changes of heart rate variability caused by ischemic heart disease. The practical part describes how to create applications in Matlab to calculate the quantifiers analysis of heart rate variability in the time domain using recurrent diagram. The calculation was made of the positions R wave elektrogram signal isolated rabbit hearts. The calculated values of quantifiers both methods were statistically evaluated and discussed.
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Tomek, Peter. „Approximation of Terrain Data Utilizing Splines“. Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236488.
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Pro optimalizaci letových trajektorií ve velmi malé nadmorské výšce, terenní vlastnosti musí být zahrnuty velice přesne. Proto rychlá a efektivní evaluace terenních dat je velice důležitá vzhledem nato, že čas potrebný pro optimalizaci musí být co nejkratší. Navyše, na optimalizaci letové trajektorie se využívájí metody založené na výpočtu gradientu. Proto musí být aproximační funkce terenních dat spojitá do určitého stupne derivace. Velice nádejná metoda na aproximaci terenních dat je aplikace víceroměrných simplex polynomů. Cílem této práce je implementovat funkci, která vyhodnotí dané terenní data na určitých bodech spolu s gradientem pomocí vícerozměrných splajnů. Program by měl vyčíslit více bodů najednou a měl by pracovat v $n$-dimensionálním prostoru.
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Belazi, Hadi S. „Sedimentology of Middle-Upper Eocene formations, Nafoora-Augila field, Libya (SPLAJ)“. Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/8580.
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8
Moore, Matthew Richard. „New mathematical models for splash dynamics“. Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c94ff7f2-296a-4f13-b04b-e9696eda9047.
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In this thesis, we derive, extend and generalise various aspects of impact theory and splash dynamics. Our methods throughout will involve isolating small parameters in our models, which we can utilise using the language of matched asymptotics. In Chapter 1 we briefly motivate the field of impact theory and outline the structure of the thesis. In Chapter 2, we give a detailed review of classical small-deadrise water entry, Wagner theory, in both two and three dimensions, highlighting the key results that we will use in our extensions of the theory. We study oblique water entry in Chapter 3, in which we use a novel transformation to relate an oblique impact with its normal-impact counterpart. This allows us to derive a wide range of solutions to both two- and three-dimensional oblique impacts, as well as discuss the limitations and breakdown of Wagner theory. We return to vertical water-entry in Chapter 4, but introduce the air layer trapped between the impacting body and the liquid it is entering. We extend the classical theory to include this air layer and in the limit in which the density ratio between the air and liquid is sufficiently small, we derive the first-order correction to the Wagner solution due to the presence of the surrounding air. The model is presented in both two dimensions and axisymmetric geometries. In Chapter 5 we move away from Wagner theory and systematically derive a series of splash jet models in order to find possible mechanisms for phenomena seen in droplet impact and droplet spreading experiments. Our canonical model is a thin jet of liquid shot over a substrate with a thin air layer trapped between the jet and the substrate. We consider a variety of parameter regimes and investigate the stability of the jet in each regime. We then use this model as part of a growing-jet problem, in which we attempt to include effects due to the jet tip. In the final chapter we summarise the main results of the thesis and outline directions for future work.
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Netzloff, Heather Marie. „Drama in Dynamics Boom, Splash, and Speed“. Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/835377-gqvCD8/webviewable/.
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19 Dec 2004.Published through the Information Bridge: DOE Scientific and Technical Information. "IS-T 1930" Heather Marie Netzloff. 12/19/2004. Report is also available in paper and microfiche from NTIS.
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Almeida, Mônica de. „Réinventions du "Spleen de Paris" : traduire Baudelaire“. Paris 8, 2006. http://www.theses.fr/2006PA082698.
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Le poème en prose est considéré comme une notion problématique dans les études sur le langage et malgré plusieurs tentatives pour définir cette écriture, elle représente encore une exception dans l’univers littéraire. Dans Le Spleen de Paris, Baudelaire fait allusion à ses poèmes comme des « accidents », comme un ouvrage « qui n’a ni queue ni tête, puisque tout, au contraire, y est à la fois tête et queue, alternativement et réciproquement ». L’objectif de ce travail est de discuter des aspects concernant le mode de fonctionnement et la singularité des Petits poèmes en prose de Baudelaire, à partir des traductions de ce recueil, surtout en langue portugaise (Brésil), mais aussi en prenant en compte des fragments des versions en anglais et en espagnol. Ces réinventions constituent des projets littéraires autonomes, orientés par des conceptions de langage distincts et en ce sens, chaque réécriture fournit des éléments pour réfléchir sur les différentes stratégies et théories de la traductionThe prose poem is considered as a problematic notion in language studies and despite many attempts to find a definition to this writing, it still remains an irregularity in the universe of literature. In Paris Spleen Baudelaire refers to his poems as an “accident”, as a work “that has neither head nor tail, since everything, on the contrary, is both head and tail, alternatively and reciprocally”. The goal of this research is to discuss some aspects concerning the principles of composition and the peculiarity of the Small Prose Poems, based on the translations of this work in Portuguese (Brazil), and also taking into account fragments of versions in English and in Spanish. These reinventions frame independent literary projects and they are oriented by distinct conceptions of language. In this way, each rewriting presents elements to think on different strategies and theories of Translation
11
Burn, Sally. „Origin and morphogenesis of the murine spleen“. Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/23965.
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This thesis establishes methods to investigate early spleen development in the mouse embryo. An expression analysis of early Nkx2.5 expression is reported, along with the finding that Nkx2.5 may be the earliest marker of splenic precursors in the mouse. Expression of Nkx2.5 is also shown for the first time to overlap considerably with that of Nkx3.2 – a major gut development gene upstream of Nkx2.5. An in silico analysis of the evolutionary conserved regions upstream of Nkx2.5 is presented along with the establishment and analysis of stable transgenic reporter lines expressing LacZ under the control of an Nkx2.5 gut regulatory sequence (NGRS). NGRS confers spleen, posterior stomach, and pyloric sphincter expression, with very little of the cardiac expression associated with endogenous Nkx2.5. This enhancer is thus ideal for gut studies, providing a tool for directing gut-specific expression and genetic manipulations. NGRS was also found not to require Nkx3.2 for its activity. Finally, NGRS is demonstrated to have the potential to mark abnormal spleen development, in a previously unreported splenic mutant: the Rwhs mutant. Potential uses for NGRS are explored. An approach was taken to mark and follow spleen development, using NGRS-LacZ in an organ culture system. Data generated from these experiments shed some light on how the E11.5 spleen develops, providing evidence for migration of splenic precursors along the stomach, and suggesting that an inhibitory “anchor” effect is normally exerted by the posterior spleno-pancreatic mesenchyme, disruption of which permits precocious spleen development. Finally, an analysis of the role of Wnt signalling in development of the spleno-pancreatic region is presented. Wnt signalling is active in the developing spleen at E11.5, E12.5 and E14.5. A number of Wnt and Frz genes are expressed in the E14.5 spleen.
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Edmond, A. M. „The spleen in sickle cell disease in childhood“. Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598759.
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Sasaki, Minoru. „Contextualisation poético-politique du spleen moderne chez Baudelaire“. 名古屋大学教養教育院, 2012. http://hdl.handle.net/2237/21051.
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Paula, Daniel Rameh de. „Le spleen de Paris : uma estética do confronto“. reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/31318.
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Dissertação (mestrado)—Universidade de Brasília, Instituto de Letras, Departamento de Teoria Literária e Literaturas, Programa de Pós-Graduação em Literatura, 2017.Submitted by Raquel Almeida (raquel.df13@gmail.com) on 2018-02-22T19:08:26Z No. of bitstreams: 1 2017_DanielRamehdePaula.pdf: 1100981 bytes, checksum: d7c0958ce3e774e645cdc02a435bbc9f (MD5)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
O objetivo deste trabalho é refletir acerca do tema do confronto em Le Spleen de Paris – Petits poèmes en prose, de Charles Baudelaire, um dos inauguradores da lírica moderna. Serão abordados, em especial, três aspectos da ideia de confronto na obra referida: o confronto estético; o confronto com o outro; e o confronto consigo mesmo. Considerando-se que o spleen figura em um dos títulos imaginados por Baudelaire para nomear a coletânea de poemas em questão, é de se supor que esse sentimento contribua para a tendência do sujeito poético da obra a estabelecer relações marcadamente conflituosas. Assim, em síntese, o problema sobre o qual se intenciona debruçar-se neste trabalho pode ser proposto do seguinte modo: em que medida a disseminação do tema do confronto em Le Spleen de Paris pode ser relacionada ao sentimento do spleen? Ao longo desse percurso, tendo como principais referenciais teóricos as teses de Antoine Compagnon, Hugo Friedrich e Walter Benjamin, será necessário evocar características fulcrais da modernidade e refletir acerca da noção de spleen, conceitos que se relacionam entre si e também com o modo como o confronto se espalha na obra em questão.
Ce travail a pour but de réfléchir à propos du sujet de l’affrontement dans Le Spleen de Paris – Petits poèmes en prose, de Charles Baudelaire, l’un des inventeurs de la poésie moderne. De manière plus spécifique, trois aspects de l’idée d’affrontement seront analysés dans l’oeuvre mentionnée: l’affrontement esthétique; l’affrontement à l’autre; l’affrontement à soi-même. En considérant que le spleen figure sur l’un des titres imaginés par Baudelaire pour nommer son recueil de poèmes, on peut supposer que ce sentiment participe à la tendance du je poétique à établir des relations assez turbulentes. En somme, la problématique sur laquelle nous nous proposons de nous concentrer peut être formulée de la manière suivante: dans quelle mesure la dissémination de l’affrontement dans Le Spleen de Paris se lie-t-elle au sentiment du spleen? Au long du parcours, en prenant pour référence théorique surtout les idées d’Antoine Compagnon, Hugo Friedrich et Walter Benjamin, il sera nécessaire d’évoquer des caractéristiques centrales de la modernité et réfléchir à propos de la notion de spleen - des concepts qui se lient l’un à l’autre et aussi à la manière dont l’affrontement se répand dans l’oeuvre ci-analysée.
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Desanti, Guillaume. „Hematopoietic and structuring process of the fetal spleen“. Paris 7, 2007. http://www.theses.fr/2007PA077093.
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Chez la souris, l'ébauche de la rate foetale apparaît à jour embryonnaire 12,5 et contient des progéniteurs myéloides et érythrocytaires. À ce stade, la circulation sanguine est déjà établie et participe à la diversification du « pool » de cellules hématopoïétiques. Au cours de la vie foetale, les cellules hématopoïétiques de la rate prolifèrent et se différencient. Jusqu'à présent, le développement de la rate, son rôle sur la constitution du système hématopoïétique et les mécanismes qui participent à sa structuration ont été peu étudiés. Au cours de ma thèse, j'ai isolé les cellules stromales CD34 et CD34+ de la rate foetale qui pourraient contribuer activement au recrutement des cellules hématopoiétiques. J'ai étudié le contenu hématopoiétique de la rate foetale à différents stades de développement. J'ai caractérisé par des essais in vitro et in vivo une population CD4'nt qui se compose de progéniteurs T, NK, B et myéloides. Ces progéniteurs se différencieraient in situ et participeraient à l'activité hématopoiétique de la rate foetale. J'ai séparé ces progéniteurs en fonction de leur expression du récepteur Flt3 et du transgène RAG2-GFP et j'ai démontré que certains d'entre eux sont capables de se différencier en cellules inductrices des tissus lymphoïdes (ITL). Les ITL jouent un rôle majeur dans la génération des organes lymphoïdes. Afin d'évaluer la fonction des ITL dans la rate foetale, j'ai étudié leur positionnement et montré leur regroupement autour des vaisseaux sanguins. Grâce à un modèle de greffes spléniques, j'ai mis en évidence que les cellules B et les ITL occupent les mêmes régions. Ces résultats suggèrent que la position des futurs follicules lymphoïdes spléniques sont pré-établis par la régionalisation des ITL dans la rate foetale. Afin de déterminer les propriétés hématopoïétiques de l'environnement de la rate foetale, j'ai participé à l'établissement de 10 lignées de cellules stromales de rate foetales et étudié leurs capacités à soutenir la différenciation lymphoïde et myéloïde. Toutes ces lignées soutiennent l'engagement et la différentiation myéloïdes mais n'ont pas la même capacité à soutenir le développement lymphoïde. Cette diversité serait caractéristique de différentes niches de cellules stromales qui composent la rate foetale. Ces niches représenteraient des structures précoces des pulpes rouge et blancheMouse splenic anlagen appears at embryonic day 12. 5 (E12. 5) and contains erythroid and myeloid progenitors. At this stage, blood circulation is established and contributes to the hematopoietic pool diversification. During fetal life, the hematopoietic cells of the spleen proliferate and differentiate. Few studies have described the development of the spleen, the mechanisms that mediate the apparition of its structure and its role in the hematopoietic System constitution. During my thesis, I have isolated the fetal spleen CD34" and CD34+ stromal cell subsets that could actively contribute to the recruitment of hematopoietic cells. I have studied the fetal spleen hematopoietic content at different stages of development. I have characterized by in vitro and in vivo assays a CD4'm population that is composed of T, NK, B and myeloid progenitors. These progenitors could differentiate in situ and participate to the hematopoietic activity of the fetal spleen. I have further isolated these progenitors by considering their expression of Flt3 and RAG2-GFP transgene and demonstrated that some are able to give rise to the lymphoid tissue inducer (LTi) cells. These LTi cells play a major role in the lymphoid organ generation. To evaluate the LTi cell function in the fetal spleen, I have assessed their localization and shown their gathering around the blood vessels. Using spleen graft strategy, I have shown that LTi cells co-localize with B lymphocytes. These results suggest that the position of the future splenic lymphoid follicles is pre-established by LTi cells regionalization in the fetal spleen. To study the hematopoietic capacities of the fetal spleen environment, I have participated to the establishment of ten different fetal spleen stromal cell lines (FeSS) and determine their capacities to support the myeloid and lymphoid differentiation. All the FeSS promote the myeloid commitment and differentiation despite their heterogeneous ability to support the lymphoid development. This diversity could be related to the different niches of stromal cells that compose the fetal spleen. These different niches could be representative of the early red or white pulp structures
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Ouakaoui, Malek. „Esthétique du spleen dans le cinéma de l'immigration“. Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAL026.
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Plus que jamais l’immigration est un sujet d’actualité. Elle fait systématiquement l’objet des campagnes électorales des pays d’accueil et révèle en filigrane un malaise grandissant dans les pays de départ. Ce malaise qui est surtout apparu après la décolonisation témoigne de la difficulté pour la plupart des pays du Sud d’accéder à une réelle souveraineté. La jeunesse de ces pays-là ressent alors un sentiment de déception et de mélancolie comparable au spleen vécu par les Romantiques français dans la période postrévolutionnaire. Le voyage vers un ailleurs fantasmé devient alors un moyen de dépassement et parfois même de survie. Mais tandis qu’au XIXe siècle, c’était l’Orient qui paraissait fascinant, notamment en littérature dite orientaliste, aujourd’hui la tendance semble s’être inversée pour donner lieu à un occidentalisme cinématographique.L’immigration suppose un départ : l’émigration ; une installation : l’immigration à proprement parlé ; et parfois même un retour : la « remigration ». Chacun de ces aspect comporte des problématiques particulières sous-jacentes et pas nécessairement en rapport les unes avec les autres. Elles sont largement traitées en études sociologiques, politiques ou même économiques. Mais ces études n’ont pas vocation à nous introduire dans la pensée intérieure de ceux qui vivent les situations. Car l’Histoire à elle seule ne suffit pas à rendre compte des événements, il lui faut aussi les mémoires, et il y a souvent une différence importante entre ceux qui racontent cette Histoire – les migrations en sont un thème majeur – et ceux qui la vivent. Le cinéma, comme la littérature ont cette spécificité de faire ressentir au lecteur ou au spectateur des situations, des sentiments, des émotions. À travers une expérience esthétique, nous sommes plus à même de comprendre les problèmes, et à défaut de pouvoir les résoudre, d’en avoir au moins conscience, comme en psychanalyseToday, more than ever, immigration is one of the most debated issues. It is systematically the subject of the electoral campaigns of the host countries and reveals a growing unease in the countries of origin of the immigrants. This uneasiness, which has especially emerged after decolonization, shows how difficult it is for most countries of the South to gain real sovereignty. The youth of these countries then feel a sense of disappointment and melancholy comparable to the spleen experienced by the French Romantics in the post-revolutionary period. The journey to a fantasy elsewhere then becomes a way both to escape and survive this world. In the nineteenth century, it was the Orient that seemed fascinating, especially in the so-called orientalist literature. Today, however, the trend seems to have reversed to give rise to cinematographic Occidentalism.Immigration presupposes a departure: emigration, settling or settlement: immigration proper; and sometimes even a return: "remigration". Each of these aspects has particular underlying issues and are not necessarily related to each other. They are widely investigated in sociological, political or even economic studies. But these studies are not intended to introduce us to the inner thinking of those who live these situations. Because History alone is not enough to account for events, it also needs memories, and there is often a significant difference between those who tell this History - migration is a major theme - and those who live it. Cinema and literature have this specificity of making the reader or the spectator feel the situations, the feelings and the emotions. Through an aesthetic experience, we are much abler to understand the problems. Though we may fail to fully solve these problems, we can at least be aware of them, as is the case in psychoanalysis
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Steward, Scott D. „The Effect of Salt Splash on Nylon 6,6“. Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/35635.
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One of the most common environmental exposures that nylon undergoes, when used for automotive applications, is that of salt splash, which commonly occurs during winter driving. This study looks at the effect of various salts (NaCl, KCl, CaCl2) on the thermal and mechanical properties of nylon when exposed to one and four molar aqueous salt solutions. It was found that the diffusion of salt solutions into nylon 6,6 occurred in a pseudo-Fickian manner. Also, it was found that the presence of salt had an effect on the rate of decrease of yield stress with increasing exposure time. The presence of residual salt was found to accelerated deterioration of nylon 6,6, possibly via hydrolysis. In addition, it was found that residual salt was left after water was removed from the system and that this salt was removable.Master of Science
18
McAdoo, Stephen. „The role of spleen tyrosine kinase in glomerulonephritis“. Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/40926.
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Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that has an important role in immunoreceptor signalling, including for the B cell receptor and activatory Fc receptors. SYK inhibition has shown efficacy in animal models of non-renal autoimmune disease. The role of SYK in experimental and clinical renal disease, however, is not well defined. I have studied the effects of SYK inhibition using a specific small molecule inhibitor (R788; fostamatinib) in two distinct experimental models of glomerulonephritis in the rat. In experimental autoimmune glomerulonephritis (EAG; a model of anti-glomerular basement membrane disease), I have shown that SYK inhibition with fostamatinib both prevents and treats established disease. Significant attenuation of humoral autoimmune responses was observed, and ELISpot and flow cytometric analysis suggests that this was due to a direct inhibitory effect on B cell activity, rather than overall B cell survival. In addition, SYK inhibition appeared to inhibit antibody-dependent, Fc receptor-mediated pro-inflammatory responses, particularly within glomerular macrophages, in EAG. In experimental autoimmune vasculitis (EAV; a model of anti-neutrophil cytoplasm antibody [ANCA] associated vasculitis), SYK inhibition was an effective treatment for life-threatening manifestations of disease, including glomerulonephritis and lung haemorrhage. I have also examined the pattern of SYK expression by immunohistochemistry in clinical renal biopsy specimens from approximately 100 patients with a spectrum of glomerular pathologies. I found that SYK is expressed and activated in proliferative types of glomerulonephritis, and that expression levels correlate with disease activity in anti-GBM disease, ANCA-associated vasculitis, lupus nephritis and IgA nephropathy. These data suggest that SYK is important in the pathogenesis of proliferative glomerulonephritis. SYK inhibition is an effective treatment strategy for the organ-threatening manifestations of disease in two experimental models, and SYK inhibition therefore warrants further investigation in human renal disease.
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Etturki, S. M. „Management development and organisational effectiveness in developing countries with special reference to Libya (SPLAJ)“. Thesis, Cardiff University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373122.
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Szabados, Luke. „Splat! Fragmented Space in Experimental Cinema“. Ohio University Honors Tutorial College / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1461940887.
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Goldbaum, Dina. „Micromechanical testing of cold sprayed Ti splats and coatings“. Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110400.
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Cold spray is a thermo-mechanical process where powder deposition is achieved through particle acceleration to supersonic velocities using a preheated and pressurized gas and a deLeval nozzle. The operating temperatures are typically below the melting point of most metals, which limits the material oxidation and phase transformations. Thick, dense coatings can be produced at fast deposition rates (20 g/min), making cold spray a candidate for near net shape production and part repair technology for aerospace applications. However, the cold-spray process is not as well documented as thermal spray techniques and the lack of the reliable experimental data limits the use of the cold spray, especially in load bearing applications.The present study explored the mechanical and microstructural properties of the cold spray titanium splats and coatings with novel micro-mechanical testing techniques coupled with high resolution microscopy. Electron channelling contrast imaging and nanoindentation mapping were used to examine the evolution of the microstructure and hardness of individual cold spray splats. The grain refinement and recrystallization were observed at particle interfaces which contributed to the strain hardening of the material. Splats deposited above critical velocity (700 - 900 m/s) exhibited nanometer scale grains with average grain diameters in the range of 50 to 200 nm at the splat/substrate interface with regions of metallurgical bonding. A modified ball bond shear test was implemented to measure the adhesion strength of individual cold spray splats. Deposition conditions under which the adhesion strength of splats reached the theoretical shear strength of titanium were identified. Coatings, produced at the same deposition conditions as strongly bonded splats, showed strong particle cohesion strength and low coating porosity. The coating porosity and poor particle cohesion strength affected the microindentation hardness measurements and tensile properties of the titanium coating. A new multi-scale indentation method was developed, where the comparison between the nanoindentation and microindentation and the definition of a "hardness loss parameter" was used to quantify the effect of the coating defects on hardness measurements. Titanium coatings that demonstrated hardness loss parameter approaching that of the bulk titanium were also coatings that demonstrated tensile properties, measured with microtensile testing technique, of fully dense material. The splat adhesion and multi-scale indentation testing techniques developed in the present research were shown to provide new methods that can be used towards optimization of the cold spray process for deposition of titanium coatings with properties of commercially manufactured material.La projection à froid est un processus thermomécanique où la déposition du revêtement est accomplie en accélérant les particules de la poudre, avec un gaz préchauffé et en pression, vers da vitesse supersonique. La température opérationnelle est, d'habitude, plus petite que le point de fusion de la plupart des métaux, ce qui limite l'oxydation et la transformation de phase. Des revêtements épais et denses peuvent être produits avec un taux de déposition rapide (20 g/min) permettant l'utilisation de la projection à froid pour la réparation des pièces et la formation des pièces proche de la forme finale pour les applications aérospatiales. Néanmoins, le processus de la projection à froid n'est pas aussi bien documenté que la projection thermique et manque de données expérimentales fiables, ce qui empêche l'application de la projection à froid aux pièces de portance. Le travail accomplis dans cette thèse est basé sur l'exploration des propriétés mécaniques et microstructurales des trempes et des revêtements par projection à froid de titane avec les nouvelles techniques micromécaniques et à l'aide de la microscopie à haute résolution. L'imagerie de contraste par canalisation et la cartographie par nanoindentation ont été utilisées pour examiner l'évolution de la microstructure et la dureté des trempes du titane. La diminution de taille des grains et la recristallisation des grains ont été observés à l'interface des particules ce qui a contribué à la hausse de dureté dans cette région. Les trempes, qui ont été déposées à une vitesse plus hautes que la vélocité critique (700 - 900 m/s), avaient des grains à l'échelle nanométrique (de 50 à 200 nm) à l'interface de trempe/substrat et présentaient des liaisons métallurgiques. Une nouvelle technique de balle au cisaillement modifié a été utilisée pour mesurer la force d'adhérence de ces trempes. Les conditions de la projection à froid, pour lesquelles les trempes ont démontré la force d'adhésion s'approchant de la force de cisaillement théorique du titane, ont était identifiées. Les revêtements, déposés aux mêmes conditions que les trempes démontrant une adhérence supérieure, ont présenté une forte cohésion des particules et une porosité du revêtement réduite. La porosité et la force de cohésion des particules avaient un effet sur les mesures de dureté et les propriétés de traction des revêtements. Une nouvelle méthode d'indentation multi-échelle a était développée dans laquelle la comparaison entre les mesures faites par nanoindentation et microindentation, définît comme le paramètre de perte de dureté, a été utilisé pour quantifier l'effet des défauts sur la mesure de dureté du revêtement. Les revêtements de titane qui avait un paramètre de perte de dureté s'approchant de celui du titane massif, ont démontré également les propriétés de traction du titane massif. Les techniques micromécaniques développées dans cette thèse, présente les nouvelles méthodes qui peuvent être utilisées envers l'optimisation du processus de projection à froid et le dépôt des revêtements de titane ayant des propriétés mécaniques de matériaux commerciaux.
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Rivers, Roger Troy. „Experimental Testing of CFRP Splays Bonded to Uniaxial Fabric“. Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321612.
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The use of fiber reinforced polymers (FRP's) for structural repair or retrofit has increased significantly in the last decade, with adoption for civil infrastructure occurring only in the last 20 years. These products are most often used to increase the capacity of damaged or deteriorated structures. Much research has been performed in the arena of testing of various FRP's bonded to both concrete and masonry substrates, the majority of which focusing on three areas; flexural strengthening, in-plane shear strengthening, and mechanical anchoring. Anchorage is commonly the limiting factor in the application of FRP's, due to the inability of the edge of the polymer matrix to reliably extend beyond a point of zero-interfacial stress. Where interfacial stresses exist and the FRP is terminated localized disbondment often occurs, these localized failures then propagate across the entire bond of the structural system. Various mechanical termination details have been tested to mitigate the potential failure modes near the ends of the fabric. There, however, has been very limited research performed on the behavior of dowels which are installed parallel to the FRP fabric and splayed onto the FRP fabric matrix. In this research the mechanical properties of carbon fiber reinforced polymer (CFRP) dowels with a parallel orientation to uniaxial carbon fabric are experimentally tested to determine the tensile capacity of "dowel to splay" CFRP connections and to discover any dominant failure modes.
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Blenkinsopp, Christopher Edwin. „Air entrainment, splash and energy dissipation in breaking waves“. Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435725.
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Brownback, Paul (Paul Eldon). „Effects of Gold Sodium Thiomalate on Murine Spleen Cells“. Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc500436/.
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The effects of gold sodium thiomalate (GST) on murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Addition of GST to intact spleen cells resulted in a decreased blastogenic response to the T cell mitogen, concanavalin A (Con A). Thymidine uptake of spleen cells depleted of macrophages and cultured with Con A and GST demonstrated biphasic effects. At 2.5 pg Con A/ml, blastogenesis of macrophage depleted spleen cells was inhibited to a lesser degree than intact spleen cells; whereas, at 0.5 pg Con A/ml, the macrophage depleted spleen cells were inhibited to a greater degree than the intact spleen cells. Addition of GST at intervals ranging from 0 to 48 hours indicated that inhibition occurred within 36 hours following mitogen stimulation. These results suggest that GST inhibits early events of lymphocyte activation by direct interaction with lymphocytes.
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You, Yuying. „Cross-talk between marginal zone B cells and marginal zone macrophages“. Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010p/you.pdf.
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Chambers, Andria. „Generation of Macrophage Chemotactic Factors by sPLA2“. VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1757.
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Removal of apoptotic cells by macrophages is required in order to prevent autoimmune responses. Previous studies have reported that group IIA secretory phospholipase A2 (sPLA2) preferentially binds to apoptotic cells and induces a chemotactic factor which promotes the migration of macrophages to apoptotic cells. Based on these observations, we hypothesized that the pool of sPLA2 trapped on apoptotic cells produces chemoattractant lipids that recruit macrophages to phagocytose the apoptotic cells. To test this hypothesis, Jurkat cells were cultured under normal conditions and induced to undergo early apoptosis through treatment with D,L-threo-dihydrosphingosine. Live and early apoptotic cells were incubated with catalytically active sPLA2 and then cell-associated catalytic activity was assessed. In contrast to previous reports, we observed no difference in the ability of live or early apoptotic cells to trap group IIA sPLA2 on their surfaces. However, transmigration assays involving THP-1 monocytes confirmed that the cell-bound pool of sPLA2 generates chemoattractants when bound to the surfaces of live cells. Surprisingly, sPLA2 does not have to be catalytically active to attract THP-1 monocytes. The treatment of live Jurkat cells with heparinase showed a marked reduction in the ability of sPLA2 to bind to live cells and exert catalytic activity, suggesting heparan sulfate proteoglycans are possibly receptors for sPLA2. Future experiments are being planned to identify sPLA2 receptor(s) on THP-1 monocytes.
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Seifert, Hilary. „The Inflammatory Response Initiated by the Spleen to Ischemic Stroke“. Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4767.
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The peripheral immune system plays a role in delayed neural injury after stroke. This response originates from the spleen as splenectomy prior to middle cerebral artery occlusion (MCAO) in rats significantly reduces infarct volume in the brain. This research is based on the hypothesis that inhibiting the splenic response will reduce neurodegeneration after stroke. Studies in animals have implicated lymphocytes as the immune cell type that is detrimental following MCAO. Interferon gamma (IFNγ) has been identified as a pro-inflammatory cytokine that is also detrimental following stroke. IFNγ is important because it activates microglia and macrophages in a pro-inflammatory nature that increases neural injury following stroke. Therefore IFNγ was examined in the brain and the spleen following MCAO. IFNγ protein was elevated at 24 h in the spleen and at 72 h in the brain post MCAO. Microglia/macrophages become maximally activated at 72 h in the brain after MCAO. Splenectomy decreases the levels of IFNγ in the brain following MCAO. Systemic administration of IFNγ reversed the protective effects of splenectomy.
The cellular response to MCAO was examined next because of the difference in time between the spike in IFNγ in the spleen and the delayed increase in the brain. The cellular response from the spleen was studied by labeling splenocytes five days prior to MCAO with a fluorescein dye. Tissues were examined 48 and 96 h post MCAO or sham MCAO for fluorescence. These cells were released from the spleen into circulation at 48 h post MCAO and migrated to the brain where the cells produced IFNγ at 96 h post MCAO.
IFNγ appears to play a role in the splenic response to stroke. One protein that is up regulated by cells that have been activated by IFNγ, interferon-inducible protein 10 (IP-10) is part of the inflammatory cycle driven by IFNγ. IP-10 recruits more IFNγ producing T helper (Th) cells to the site of injury. IP-10 has the unique ability to attract Th1 cells, the pro-inflammatory Th cells, and inhibit Th2 cells, the anti-inflammatory Th cells. This leads to more IFNγ production as IFNγ is the signature cytokine of a Th1 response. IP-10 is significantly increased in the brain at 72 h post MCAO, similar to IFNγ expression. In the spleen IP-10 increased at 24 h and remained elevated out to 96 h following MCAO. IFNγ signaling was inhibited by utilizing an IFNγ neutralizing antibody administered beginning 24 h post MCAO. The IFNγ antibody treated group had decreased infarct volumes, IP-10 levels in the brain, and appeared to have decreased T cells in the ipsilateral hemisphere at 96 h post MCAO.
Following ischemic stroke splenocytes are released into circulation and migrate to the brain. They release IFNγ to activate microglia/macrophages in a proinflammatory phenotype causing an increase in IP-10 levels. IP-10 then potentiates the Th1 driven inflammation which inhibits the Th2 response. The elevated levels of IFNγ increase neural injury following MCAO. Blocking IFNγ selectively blocks the inflammatory facet of the immune response to reduce stroke induced neurodegeneration. This leaves the other immune responses intact and able to contribute to tissue repair, regeneration, and able to respond to infections. Selectively inhibiting IFNγ signaling is a promising stroke therapeutic.
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Vines, David John. „The purification and characterisation of tripeptidyl peptidase-1 from spleen“. Thesis, St George's, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265248.
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MacDonald, Oliver Charles. „Splash on leaves and the dispersal of spore carrying droplets“. Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47549.
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Watkins, Alan James. „Molecular characterization of splenic marginal zone lymphoma“. Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609484.
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Exeter, H. J. „The genetic architecture of secretory PLA2 (sPLA2) genes and their impact on sPLA2 activity/mass and association with CHD risk“. Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1380418/.
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Secretory phospholipase A2 group (sPLA2) enzymes hydrolyze the sn-2 ester bond of phospholipids, producing lysophospholipids and free fatty acids. SPLA2s have been identified as biomarkers of atherosclerosis in observational and animal studies. The aim of this study was to identify functional variants in PLA2G2A and, to a lesser extent, PLA2G5 and PLA2G10 (sPLA2 encoding genes). These variants could then serve as tools to examine their contribution to sPLA2-activity, since this is a composite measure of sPLA2-IIA,-V and –X, and associations with CHD risk/CHD traits. Two PLA2G2A SNPs were identified as being associated with sPLA2-IIA mass/sPLA2 activity. Luciferase assays, EMSA and RNA expression were used to examine their allelic differences. Rs3767221G showed ∼55% lower luciferase activity compared to rs3767221T (p = 1.22×10-35), and stronger EMSA binding of a nuclear protein compared to the T-allele. For rs11573156 C >G there were no luciferase or EMSA allelic differences. For rs11573156 there was no differential allelic lymphocyte cDNA expression for exons 5-6, but G-allele carriers (n = 7) showed a trend to lower exon 1-2 expression versus CC individuals. In the ASAP study (n = 223), a SNP acting as a proxy for rs11573156 (r2 = 0.91) on the expression array showed allelic difference of ∼25% in liver expression of total PLA2G2A (1.67×10-17). However, exon 2 specific expression was greatly reduced (4.5×10-5) compared to exons 3-6 (10-10 to 10-20), implying allele-specific exon 2 skipping as the functional basis of rs11573156 association. Rs11573156 was used as a genetic tool in a large Mendelian randomisation (MR) collaboration to establish the causality of sPLA2-IIA for CHD. While the sPLA2-IIA mass was strongly associated with CHD events, rs11573156 was not associated with outcome. Similar approaches were taken for studying PLA2G5 and PLA2G10, using eQTL data and smaller meta-analyses. Both PLA2G2A SNPs are functional. Using rs11573156 as a genetic instrument, MR suggested that sPLA2-IIA is not causally associated with CHD. Based on initial meta-analyses, neither PLA2G5 nor PLA2G10 appeared to be associated significantly with sPLA2 activity in cardiovascular related tissues. This conclusion is consistent with the outcome of the recent Phase III trial for the sPLA2 inhibitor varespladib, which was terminated due to lack of efficacy since the drug was shown to be having no significant effect on the reduction of secondary cardiovascular events.
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Luu, Li-Hua. „Impact de gouttes de fluides à seuil : rhéologie, splash et cratères“. Phd thesis, Université de Provence - Aix-Marseille I, 2011. http://tel.archives-ouvertes.fr/tel-00580981.
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Cette thèse présente une étude expérimentale de l'impact de gouttes de fluides à seuil. Au-delà des applications (impression à jet d'encre solide, modélisation d'impact solide à grandes vitesses), cette étude permet de sonder le rôle de l'élasticité sur le comportement à temps court de ces fluides complexes. D'abord, nous nous sommes intéressés aux impacts sur une surface rigide. L'utilisation de fluides à seuil modèles (solutions concentrées d'argiles, micro-gel de Carbopol) et de surfaces d'impact variées (partiellement mouillante ou super-hydrophobe), révèle une grande variété de comportements, allant de l'étalement viscoplastique irréversible jusqu'à des déformations élastiques géantes. Un modèle minimal d'étalement inertiel, incluant une rhéologie élasto/viscoplastique, permet de décrire dans un cadre unique les principaux régimes observés. Au cours de cette étude, nous avons mis en évidence un phénomène spécifique avec le Carbopol : pour des grandes vitesses d'impact, on observe un étalement beaucoup plus grand sur des surfaces rugueuses hydrophobes que sur des surfaces lisses. Cette réduction apparente du frottement basal est discutée en termes de longueur de glissement et d'instabilité de " splash ". Enfin, nous avons étudié l'impact d'une goutte de fluide sur un sol constitué du même fluide, en utilisant un fluide à seuil transparent (Carbopol). La combinaison de lois d'échelle, d'expériences en " micro-gravité " et de mesures locales du champ de déformation montre que la dynamique du cratère transitoire est dominée par l'élasticité, même au-delà du seuil d'écoulement. Ces résultats pourraient avoir des implications dans le contexte des impacts de météorites en astrophysique.
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Wardemann, Hedda. „B-cell development and function in the absence of the spleen“. [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963774301.
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Hicks, Julie Ann. „MicroRNAs in the spleen and liver of the developing chick embryo“. NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-03252007-215944/.
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MicroRNAs are small (~19-24nt) non-coding RNAs that are involved in the regulation of gene expression. They are mainly expressed in development and many are expressed in a temporal as well as, a spatial manner. It is thought they may regulate up to 30% of all genes. Pyrosequencing using 454 Life Science technology is becoming the preferred method for microRNA profiling ad sequencing compared to the previous method of cloning and using traditional sequencing techniques. Use of 454 Life Sciences technology allows for a greater coverage of microRNAs and increases the chances of sequence low abundance microRNAs. In the current project we created four small RNA libraries from embryonic chick tissues, the spleen and liver at developmental time points E15 and E20. These libraries were then sequenced using 454 Life Sciences pyrosequencing. A total of 92,919 sequence reads were obtained, representing a total of 52,001 known chicken microRNAs. Of these 92,919 reads, 52,001 represented miRNAs matching the miRBase G. gallus database, and 3,472 were not found in the G. gallus database but were homologues of miRBase miRNAs from other species. Of these homologous reads 391 represented potential novel miRNAs. Other small RNAs, such as tRNA and rRNA, represented 24,672 of the reads, and 12,383 reads represented other types of sequences, such as degraded mRNA. More than one hundred different known miRNAs were identified in this study, and many were expressed in all four libraries. Common miRNAs that yielded multiple reads from all four libraries included miR-125b and miR-21, which are involved in general processes of cellular proliferation. Overall, the spleen libraries had a larger array of miRNAs than the liver libraries. Much of spleen development occurs during the later stages of embryonic development, so we can reasonably expect that many gene expression changes occur during these stages. As a result of this study, we identified nine potential novel chicken miRNAs. These novel miRNAs appear to be tissue-specific. The potential novel miRNAs appeared to be expressed at lower levels than some of the known miRNAs, which could indicate that most of the highly-expressed chicken miRNAs have already been identified, whereas, for the most part, the miRNAs expressed at low levels remain to be discovered.
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Chan, Paula Elizabeth. „Making a Splash: Eliminating Water Phobia and Increasing Confident Water Skills“. Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3038.
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The purpose of this study was to utilize a multi-component intervention to increase confident water skills for three typically developing children, and to evaluate whether fearful behaviors decreased as the intervention progressed. The intervention, comprised of goal setting, self-monitoring, behavioral skills training and positive reinforcement, was used in community pools to teach basic water skills. Results suggest the intervention was successful in increasing confident water skills, while intervals with positive affect and fearful behaviors demonstrated variability.
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Wild, Corinne. „Involvement of the ephrin-B2 ligand in spleen development and function /“. [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000277025.
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Murtaza, Ghulam, Muhammad Khalid, Majd Kanaa und Jack Stanley Goldstein. „Pancreatic Pseudocyst Complicated by Hemorrhage into the Peritoneal Cavity and Spleen“. Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/214.
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Pancreatic pseudocysts are a complication of acute or chronic pancreatitis or result from blunt trauma to the pancreas. It is a localized fluid collection around the pancreas surrounded by a wall of fibrous tissue or inflammation. We present a case of a 56-years old male who presented with abdominal pain and sepsis due to spontaneous rupture of the hemorrhagic pancreatic cyst into the peritoneal cavity and spleen.
56-years old male with medical history of gastroesophageal reflux disease presented with epigastric and left upper quadrant intermittent abdominal pain. Patient denied fever, chills, nausea, and vomiting, family history of pancreatic cancer, anticoagulation use, gallstones, alcohol intake and prior history of pancreatitis. On admission, vitals were B.P 137/82, Pulse 102, RR 16, O2 saturation 92% on room air. Physical exam was significant for left upper quadrant and epigastric tenderness. Labs were lipase 230, amylase 112, lactate 0.7, wbc 7.0, hemoglobin of 15.2 and triglyceride levels were 189mg/dl. Computed tomography (CT) abdomen showed acute pancreatitis and a 4.5 x 4.4 x 2.8 cm cystic lesion between the tail of the pancreas and splenic hilum. Ultrasound of the abdomen showed normal gallbladder with no evidence of biliary ductal dilatation. Magnetic resonance cholangiopancreatography (MRCP) abdomen showed 4.3 cm walled off, possibly hemorrhagic fluid collection, between the spleen and the pancreas. Patient had normal CA-19 level. Patient was evaluated by general surgery who recommended conservative management with repeat CT in 6 weeks with possible pancreatectomy and removal of mass if not resolved. Patient was readmitted 3 days after discharge with worsening abdominal pain and sepsis. Physical exam was significant for epigastric and left upper quadrant tenderness without guarding or rebound. Labs showed lactate 3.4, wbc 11.3, hgb 12.1 and lipase 600. Repeat CT scan showed rupture of the hemorrhagic pancreatic cyst with possible extravasation and enlarged spleen with perisplenic and subcapsular blood represent splenic infarcts. Repeat MRCP confirmed CT findings. Patient was planned for splenectomy and distal pancreatectomy.
Most pancreatic pseudocysts resolve spontaneously [1]. Bleeding, infection, rupture, pseudoaneurysm, splenic and biliary complications and portal hypertension are some of the complications if left untreated. Hemorrhage into the pancreatic pseudocyst is a rare complication with a reported incidence of 10-30% with a high mortality rate (40%). Bleeding most commonly involves splenic artery (30–50%), followed by the gastroduodenal artery (17%) and pancreaticoduodenal arteries (11%) [2]. Diagnosis is made by ultrasound, CT scan, MRI or ERCP. Treatment involves either percutaneous drainage, or endoscopic or surgical approach. Spontaneous rupture into the peritoneal cavity is a rare life threatening complication requiring immediate surgical intervention. This case highlights the early recognition of complications of ruptured pancreatic pseudocyst to prevent fatal consequences.
References:
1: Lerch MM, Stier A, Wahnschaffe U, Mayerle J: Pancreatic Pseudocysts: Observation, Endoscopic Drainage, or Resection. Deutsches Ärzteblatt International 2009, 106:614-621.10.3238/arztebl.2009.0614.
2: Novacic K1, Vidjak V, Suknaic S, Skopljanac A: Embolization of a large pancreatic pseudoaneurysm converted from pseudocyst (hemorrhagic pseudocyst). JOP 2008, 9:317-21. joplink.net/prev/200805/13.html
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Alshabanah, Othman A. „Polyamine and acetylpolyamine levels during phenylhydrazine-induced erythropoiesis in mouse spleen“. Scholarly Commons, 1988. https://scholarlycommons.pacific.edu/uop_etds/3406.
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The phenylhydrazine-induced erythropoietic mouse spleen is used as a model system to demonstrate the relationship between tissue growth and polyamine metabolism. Phenylhydrazine produced significant changes in spleen weights, hematocrits and reticulocyte counts in Swiss-Webster mice. The average spleen weight went up from a control of 155 mg to 875 mg at 96 hours after phenylhydrazine administration, while a 49% reduction in the value of hematocrit was observed at 72 hours. Reticulocyte counts in peripheral blood went from 0.8 to 58% at 168 hours after treatment with phenylhydrazine. Phenylhydrazine at a dose of 40 mg/kg produced significant increases in the levels of putrescine, spermidine and spermine with maxima reached within 72 hours. The levels of N$\sp1$-acetylspermidine reached a maximum of 2.7-fold compared to control at 96 hours. When the dose of phenylhydrazine was increased to 120 mg/kg, peak levels of acetylated polyamines were reached within 96 hours at which time N$\sp1$-acetylspermidine levels rose to 2.9-fold and N$\sp8$-acetylspermidine levels went from not detectable to detectable levels. the levels of putrescine, spermidine and spermine reached maxima at 96 hours of 289, 1248 and 934 nmoles/g, respectively. DL-$\alpha$-difluoromethylornithine hydrochloride monohydrate (DFMO) inhibited the increases in putrescine levels and potentiated the increases in spermine levels induced by phenylhydrazine, while 7-(N-(3-aminopropyl)amino) heptan-2-one.2HCl (APAH) induced significant increases in the levels of N$\sp8$-acetylspermidine. APAH potentiated the increases in spleen weights induced by phenylhydrazine.
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Fross, Bradley K. „Splash-2 shared-memory architecture for supporting high level language compilers“. Thesis, Virginia Tech, 1995. http://hdl.handle.net/10919/42064.
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Modem computer technology has been evolving for nearly fifty years, and has seen many architectural innovations along the way. One of the latest technologies to come about is the reconfigurable processor-based custom computing machine (CCM). CCMs use field programmable gate arrays (FPGAs) as their processing cores, giving them the flexibility of software systems with performance comparable to that of dedicated custom hardware. Hardware description languages are currently used to program CCMs. However, research is being performed to investigate the use of high-level languages (HLLs), such as the C programming language, to create CCM programs. Many aspects of CCM architectures, such as local memory systems, are not conducive to HLL compiler usage. This thesis proposes and evaluates the use of a shared-memory architecture on a Splash-2 CCM to promote the development and usage of HLL compilers for CCM systems.
Master of Science
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Lodin, Angelica. „Initiation of spleen contraction resulting in natural blood boosting in humans“. Doctoral thesis, Mittuniversitetet, Avdelningen för hälsovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-25518.
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The spleen has been shown to contract in apneic situations in humans as well as in other diving mammals, expelling its stored red blood cell content into circulation. This natural blood boosting may increase the circulating hemoglobin concentration (Hb) by up to 10%, which would enhance the oxygen carrying capacity and likely increase performance. However, the triggers of this response in humans have not been fully clarified. Study I was therefore focused on the effect of hypoxia as a trigger of spleen contraction. It was found that 20 min of normobaric hypoxic breathing evoked a substantial reduction in spleen volume showing that hypoxia is an important trigger for spleen contraction. Knowing the role of hypoxia, Study II compared two different hypoxic situations – a 2 min apnea and 20 min normobaric hypoxic breathing – which resulted in the same level of arterial hemoglobin desaturation. Apnea evoked a twice as great spleen volume reduction, implying that variables other than hypoxia were likely involved in triggering spleen contraction. This may be hypercapnia which is present during apnea but not during normobaric hypoxic breathing. Study III therefore investigated the effects of breathing gas mixtures containing different proportions of CO2 prior to maximal apneas. Pre-breathing mixtures with higher percentages of CO2 resulted in greater spleen contraction, thus demonstrating hypercapnia's likely role as a trigger in addition to hypoxia. Study IV explored whether an all-or-nothing threshold stimulus for triggering spleen contraction existed, or if contraction was graded in relation to the magnitude of triggering stimuli. Exercise was therefore performed in an already hypoxic state during normobaria. Rest in hypoxia produced a moderate spleen volume reduction, with an enhanced spleen contraction resulting after hypoxic exercise, with a concomitant increase in Hb. This implies that spleen contraction is a graded response related to the magnitude of the stimuli. This could be beneficial in environments with varying oxygen content or work loads. Study V examined the possibility that spleen contraction is part of the acclimatization to altitude, during an expedition to summit Mt Everest. The long-term high altitude exposure, combined with physical work on the mountain, had no effects on resting spleen volume but resulted in a stronger spleen contraction, when provoked by apnea or exercise. This indicates that acclimatization to altitude may enhance the contractile capacity of the spleen, which may be beneficial for the climber. From these studies I concluded that hypoxia is an important trigger for spleen contraction but that hypercapnia also contributes in apneic situations. The spleen contraction likely provides a graded expulsion of erythrocytes in response to these stimuli, causing a temporary increase in gas storage capacity that may facilitate activities such as freediving and climbing. The storage of erythrocytes during rest serves to reduce blood viscosity, which would also be beneficial for the climber or diver. The human spleen contraction appears to become stronger with acclimatization, with beneficial effects at altitude. Such an upgraded response could be beneficial both in sports and diseases involving hypoxia.
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Luu, Li-hua. „Impact de gouttes de fluides à seuil : rhéologie, splash et cratères“. Thesis, Aix-Marseille 1, 2011. http://www.theses.fr/2011AIX10023/document.
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Cette thèse présente une étude expérimentale de l'impact de gouttes de fluides à seuil. Au-delà des applications (impression à jet d’encre solide, modélisation d’impact solide à grandes vitesses), cette étude permet de sonder le rôle de l'élasticité sur le comportement à temps court de ces fluides complexes. D'abord, nous nous sommes intéressés aux impacts sur une surface rigide. L'utilisation de fluides à seuil modèles (solutions concentrées d’argiles, micro-gel de Carbopol) et de surfaces d'impact variées (partiellement mouillante ou super-hydrophobe), révèle une grande variété de comportements, allant de l'étalement viscoplastique irréversible jusqu'à des déformations élastiques géantes. Un modèle minimal d'étalement inertiel, incluant une rhéologie élasto/viscoplastique, permet de décrire dans un cadre unique les principaux régimes observés. Au cours de cette étude, nous avons mis en évidence un phénomène spécifique avec le Carbopol : pour des grandes vitesses d'impact, on observe un étalement beaucoup plus grand sur des surfaces rugueuses hydrophobes que sur des surfaces lisses. Cette réduction apparente du frottement basal est discutée en termes de longueur de glissement et d'instabilité de « splash ». Enfin, nous avons étudié l’impact d'une goutte de fluide sur un sol constitué du même fluide, en utilisant un fluide à seuil transparent (Carbopol). La combinaison de lois d'échelle, d’expériences en « micro-gravité » et de mesures locales du champ de déformation montre que la dynamique du cratère transitoire est dominée par l’élasticité, même au-delà du seuil d’écoulement. Ces résultats pourraient avoir des implications dans le contexte des impacts de météorites en astrophysiqueThis thesis presents an experimental study on the drop impact of yield-stress fluids. Beyond applications (solid ink-jet printing, lab modelling of high-speed collision of solids), this study offers a mean to probe the role of the elasticity on the short-time behaviour of these complex fluids. We have first studied drop impacts on solid rigid surfaces. Using different model yield-stress fluids (clay suspensions, Carbopol micro-gel) and impacted surfaces (partially wettable, super-hydrophobic), we have observed a rich variety of behaviours ranging from irreversible viscoplastic coating to giant elastic spreading and recoil. A minimal model of inertial spreading, including an elasto/viscoplastic rheology, allows explaining in a single framework the different regimes and scaling laws. In this study, we identified a specific phenomenon with Carbopol: for large impact velocities, the drop spreads much more on rough hydrophobic surfaces than on smooth surfaces. This apparent reduction of the basal friction is discussed in terms of slip length and splash instability. Endly, we investigated the impact of a drop onto a pool of the same fluid, using a transparent yield-stress fluid (Carbopol). The combination of scaling laws, micro-gravity experiments and local deformation measurements shows that the transient crater is dominated by elasticity, even beyond the flow threshold. These results could have implications for impact cratering in Planetary Sciences
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Sayed, Hassan Adelyar. „The Complexity of Splay Trees and Skip Lists“. Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6858_1263424080.
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Our main results are that splay trees are faster for sorted insertion, where AVL trees are faster for random insertion. For searching, skip lists are faster than single class top-down splay trees, but two-class and multi-class top-down splay trees can behave better than skip lists.
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Nesky, Amy Lynn. „Stability of Splay States in Coupled Oscillator Networks“. Thesis, Boston College, 2013. http://hdl.handle.net/2345/3022.
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Thesis advisor: Renato MirolloThere are countless occurrences of oscillating systems in nature. Climate cycles and planetary orbits are a few that humans experience daily. Man has also incorporated, to his benefit, oscillation into his craft; the grandfather clock, for example, can keep track of time with astounding accuracy using the period of a long pendulum. Such systems can range in complexity in a number of ways. The governing equation for a given oscillator could be as simple as a sine curve, or its motion could appear so erratic that oscillatory motion is undetectable to viewers. The number of oscillators in a system can also vary, and oscillators can be coupled; that is, oscillators can be affected by the motion of neighboring oscillators. It is this last case we wish to study. We will briefly look at the case of finitely many oscillators and then move to analyzing a model consisting of infinitely many identical oscillators. Synchrony is the simplest collective behavior. We will study a more complicated pattern called splay states in which oscillators are equally staggered in phase, i.e. phase locked such that the system will return to this pattern if it is disturbed by an arbitrarily small amount. Mathematically, this requires us to find attracting fixed points in the system. We will approximate the local behavior of our model by linearizing the system near its fixed points. We will then apply our findings to a few specific cases of such models including: uniform density, linear distribution, alpha-function pulses, and integrate-and-fire
Thesis (BS) — Boston College, 2013
Submitted to: Boston College. College of Arts and Sciences
Discipline: College Honors Program
Discipline: Mathematics
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Esposito, Christopher. „Differential Sedimentation In A Mississippi River Crevasse Splay“. ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/1308.
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In this study the patterns of sediment transport and deposition in the channels and receiving basin of a crevasse splay in the modern Mississippi River delta are examined, with emphasis on the development of a distributary mouth bar. Simultaneous hydroacoustic and optical measurements on the mouth bar show that the bar conforms to the progradational stage of an existing conceptual model of mouth bar development. This is confirmed by cores dated using Beryllium-7, which provides a record of the deposition on the bar over a 90-day period. Stratigraphic data from cores obtained on the bar are used to extend the conceptual model to account for variable riverine inputs. A numerical model, developed and validated using field data is capable of representing the fundamental sedimentary processes responsible for mouth bar progradation. These results will be of interest to coastal geologists, engineers and coastal managers alike.
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Rouault, Morgane. „Diversité moléculaire et fonctionnelle des phospholipases A2 sécrétées : clonage d'une nouvelle SPLA2 de mammifères : étude des propriétés moléculaires des SPLA2 de mammifères : étude des relations structure-fonction de la SPLA2 de venin OS2“. Nice, 2004. http://www.theses.fr/2004NICE4119.
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Les phospholipases A2 (PLA2) constituent aujourd’hui une superfamille de protéines intracellulaires et sécrétées avec plus de vingt membres chez les mammifères. Les PLA2 catalysent l’hydrolyse des phospholipides pour libérer un acide gras et un lysophospholipide. Aujourd’hui, douze sPLA2 ont été clonées chez les mammifères. Bien que beaucoup des fonctions des sPLA2 de mammifères restent encore à caractériser, celles-ci sont impliquées dans la libération de médiateurs lipidiques, mais aussi dans l’inflammation, les pathologies associées et le cancer. Cette variété d’affets biologiques est vraisemblablement due à l’activité enzymatique des sPLA2, mais aussi à la présence de récepteurs et de protéines de liaison capables de lier les sPLA2. Cette thèse a tout d’abord permis le clonage d’une nouvelle sPLA2 de mammifères appelée XIIB et mutée au centre actif. Elle constitue la première sPLA2 de mammifères catalytiquement inactive et exprimée dans différents tissus. L’expression recombinante des sPLA2 de souris a permis de déterminer leurs propriétés enzymatiques et de liaison sur le récepteur M. Ces sPLA possèdent des activités spécifiques variant de plus de mille fois selon le substrat. De plus, 5 sPLA2 de souris des groupes I/II/V/X sont des ligands du récepteur M. Les sPLA2 apparaissent donc come des protéines bifonctionnelles à la fois enzymes et ligands. Enfin, nous avons entrepris une étude des relations structure-fonction avec la sPLA2 de venin OS2. Nous avons mis en évidence que la région d’OS2 incluant l’hélice N-terminale et la boucle de liaison du CA2+ est cruciale pour l’activité enzymatique, la liaison aux récepteurs et les effets biologiquesPhospholipases A2 are enzymes that catalyze the hydrolysis of glycerophopholipids at the sn-2 position to release free fatty acids and lysophospholipids. Over the past few years, it has been realized that PAL2 constitute in mammals a superfamily of enzymes comprising extracellular and intracellular proteins. Today, 12 sPLA2 have been cloned in mammals. Despite the fact that sPLA2 functions have not yet been elucidated, it seems like they are implicated in lipid mediators release and also in inflammatory diseases and cancer. This variety of biological functions is probably due to enzymatic activity but also to binding of sPLA2 on receptors. In the present work, we first cloned a new mammalian sPLA2 called XIIB and devoid of enzymatic activity. This new protein is the first mammalian sPLA2 lacking enzymatic activity and expressed in several tissues. Then, by using the recombinant form of all mammalian sPLA2, we determined the enzymatic and binding properties of these proteins. These studies show us that despite the fact that these enzymes are members of the same family, they display very different enzymatic properties, and 5 of them could be endogenous ligands for the M-type receptor; In a third work, we performed a structure-function relationships study of the venom sPLA2 OS2 and found that a unique region of the enzyme comprising the N-terminal helix and the calcium binding loop is involved in enzymatic activity, binding to receptors and biological effects of OS2
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Davis, Leena. „Architecture of Deep-Marine Interchannel Deposits: Isaac Formation, Windermere Supergroup (Neoproterozoic), Southern Canadian Cordillera“. Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19756.
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The Windermere turbidite system, exposed in the southern Canadian Cordillera, east-central British Columbia, is a continental scale, passive margin, submarine fan system, part of which is well exposed in the Castle Creek study area. Here millimetre- to decametre-scale sedimentological and stratigraphic observations identified five facies in interchannel strata: very thin- to medium-bedded turbidite (F1), thick-bedded turbidite (F2) coarse-tail graded structureless sandstone (F3), mudstone clast breccia (F4) and carbonaceous mudstone (F5) and four architectural elements: channel (AE1), distal levee (AE2), overbank splays (AE3) and crevasse splays (AE4). These elements are assembled into a predictive depositional model that describes the initiation and evolution of sandy splay elements developed in distal levee strata of deep-marine slope channels. These data can be used in hydrocarbon exploration to identify and differentiate splay deposits in core and on seismic, and thereby improve the accuracy of subsurface reservoir models.
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Richardson, Matt X. „Hematological changes arising from spleen contraction during apnea and altitude in humans“. Doctoral thesis, Mittuniversitetet, Institutionen för naturvetenskap, teknik och matematik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-7786.
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KONDO, TATSUHEI, HIDEO KAMEI, FUMIHIRO KOBAYASHI, TAKAO YUKAWA, KEISUKE TERABE, YASUHISA HASEGAWA, YOHICHI ITOH und TAKASHI KOJIMA. „Colony-Stimulating Activity in Cultures of Human Spleen and Bone Marrow Cells“. Nagoya University School of Medicine, 1986. http://hdl.handle.net/2237/17486.
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IWATA, HISASHI, MASARU OHASHI und HIROSHI SHIGENO. „Glycosaminoglycan in Liver and Spleen of Casein-Induced Experimental Amyloidosis of Mice“. Nagoya University School of Medicine, 1985. http://hdl.handle.net/2237/17484.
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Atmadi, Alexander. „Cutting fluid aerosol from splash in turning : analysis for environmentally conscious machining“. Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/19603.
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