Zeitschriftenartikel zum Thema „Somatic gain of mutation STAT3“
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Koskela, Hanna, Samuli Eldfors, Henrikki Almusa, Emma Andersson, Pekka Ellonen, Henrik Edgren, Pirjo Koistinen et al. „Recurrent Missense Mutations in the STAT3 Gene in LGL Leukemia Provide Insights to Pathogenetic Mechanisms and Suggest Potential Diagnostic and Therapeutic Applications“. Blood 118, Nr. 21 (18.11.2011): 936. http://dx.doi.org/10.1182/blood.v118.21.936.936.
Der volle Inhalt der QuelleChomczynski, Peter W., Michael J. Clemente, Srinivasa Reddy Sanikommu, Alek d. Nielsen, Cassandra M. Hirsch, Hanna Rajala, Mikkael A. Sekeres et al. „Next-Generation Sequencing Analysis of Clonal Hierarchy and Dynamics in T-Large Granular Lymphocyte Leukemia Suggests Emergence of STAT3 Clones within Pre-Existing Dominant T-Cell Repertoire Responses Otherwise Silenced in Normal Individuals“. Blood 128, Nr. 22 (02.12.2016): 2731. http://dx.doi.org/10.1182/blood.v128.22.2731.2731.
Der volle Inhalt der QuelleLesmana, Harry, Marcela Popescu, Sara Lewis, Sushree Sangita Sahoo, Charnise Goodings-Harris, Mihaela Onciu, John Kim Choi, Clifford Takemoto, Kim E. Nichols und Marcin Wlodarski. „Germline Gain-of-Function JAK3 Mutation in Familial Chronic Lymphoproliferative Disorder of NK Cells“. Blood 136, Supplement 1 (05.11.2020): 9–10. http://dx.doi.org/10.1182/blood-2020-142078.
Der volle Inhalt der QuelleRajala, Hanna L. M., Thomas Olson, Sonja Lagström, Pekka Ellonen, Syed Arshi Uz Zaman, Emma I. Andersson, Michael J. Clemente et al. „Multiple STAT3 Mutations In Different Lymphocyte Clones Of Large Granular Lymphocytic Leukemia Patients“. Blood 122, Nr. 21 (15.11.2013): 2559. http://dx.doi.org/10.1182/blood.v122.21.2559.2559.
Der volle Inhalt der QuelleNabhani, Schafiq, Hagit Miskin, Cyrill Schipp, Dan Harlev, Shoshana Revel-Vilk, Michael Gombert, Sebastian Ginzel, Arndt Borkhardt, Polina Stepensky und Ute Fischer. „Activating Mutation of STAT3 Protects Lymphocytes from Apoptosis and Leads to a Clinical Phenotype Resembling the Autoimmune Lymphoproliferative Syndrome“. Blood 126, Nr. 23 (03.12.2015): 2218. http://dx.doi.org/10.1182/blood.v126.23.2218.2218.
Der volle Inhalt der QuelleWang, T. Tiffany, Jun Yang, Shubha Dighe, Matthew W. Schmachtenberg, Nathan T. Leigh, Emily Farber, Suna Onengut-Gumuscu et al. „Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation“. Cancers 12, Nr. 1 (03.01.2020): 126. http://dx.doi.org/10.3390/cancers12010126.
Der volle Inhalt der QuelleKim, Daehong, Mikko Myllymäki, Matti Kankainen, Timo Jarvinen, Giljun Park, Roberta Bruhn, Edward L. Murphy und Satu Mustjoki. „Somatic STAT3 Mutations in CD8+ T Cells of HTLV-2 Positive Blood Donors“. Blood 138, Supplement 1 (05.11.2021): 3133. http://dx.doi.org/10.1182/blood-2021-146326.
Der volle Inhalt der QuelleKunter, Ghada M., Fulu Liu, Maxwell Krem und Daniel Link. „G-CSF Receptor Mutations Found in Patients with Severe Congenital Neutropenia Confer a Strong Competitive Growth Advantage at the Hematopoietic Stem Cell Level That Is Mediated by STAT5 Activation.“ Blood 108, Nr. 11 (16.11.2006): 632. http://dx.doi.org/10.1182/blood.v108.11.632.632.
Der volle Inhalt der QuelleMailloux, Adam W., Jeff Painter, Eric Padron, Thomas P. Loughran und Pearlie K. Epling-Burnette. „Common γ Chain (γc) Cytokine Hypersensitivity Leads To T-Cell Homeostatic Deregulation Independent Of STAT3 Mutation In Large Granular Lymphocyte Leukemia“. Blood 122, Nr. 21 (15.11.2013): 1628. http://dx.doi.org/10.1182/blood.v122.21.1628.1628.
Der volle Inhalt der QuellePastore, Friederike, Aishwarya Krishnan, Henrik M. Hammarén, Olli Silvennoinen, Benedict Yan und Ross L. Levine. „JAK2S523L, a novel gain-of-function mutation in a critical autoregulatory residue in JAK2V617F− MPNs“. Blood Advances 4, Nr. 18 (21.09.2020): 4554–59. http://dx.doi.org/10.1182/bloodadvances.2019001283.
Der volle Inhalt der QuelleMasle-Farquhar, Etienne, Kathryn Payne, Mandeep Singh, Geetha Rao, Ghamdan Al-Eryani, Christopher Jara, Katherine Jackson et al. „The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells“. Journal of Immunology 204, Nr. 1_Supplement (01.05.2020): 142.35. http://dx.doi.org/10.4049/jimmunol.204.supp.142.35.
Der volle Inhalt der QuelleMilosevic Feenstra, Jelena D., Harini Nivarthi, Heinz Gisslinger, Emilie Leroy, Elisa Rumi, Ilyas Chachoua, Klaudia Bagienski et al. „Whole Exome Sequencing Identifies Novel MPL and JAK2 M utations in Triple Negative Myeloproliferative Neoplasms“. Blood 126, Nr. 23 (03.12.2015): 606. http://dx.doi.org/10.1182/blood.v126.23.606.606.
Der volle Inhalt der QuelleLukes, Julius, Eliska Potuckova, Julia Starkova, Jan Stary, Jan Zuna, Jan Trka und Marketa Zaliova. „Chromosome 21 Gain Is Dispensable for Transient Myeloproliferative Disorder (TMD) Development“. Blood 132, Supplement 1 (29.11.2018): 2764. http://dx.doi.org/10.1182/blood-2018-99-112078.
Der volle Inhalt der QuelleViganò, Elena, Gerben Duns, Daisuke Ennishi, Randy D. Gascoyne, Ryan D. Morin, David W. Scott und Christian Steidl. „Recurrent IL4R Somatic Mutations in Diffuse Large B-Cell Lymphoma Lead to an Altered Gene Expression Profile and Changes in Tumor Microenvironment Composition“. Blood 132, Supplement 1 (29.11.2018): 669. http://dx.doi.org/10.1182/blood-2018-99-110473.
Der volle Inhalt der QuelleGerbaulet, Alexander, Claudia Wickenhauser, Julia Scholten, Katrin Peschke, Sebastian Drube, Hans-Peter Horny, Thomas Kamradt et al. „Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit“. Blood 117, Nr. 6 (10.02.2011): 2012–21. http://dx.doi.org/10.1182/blood-2008-11-189605.
Der volle Inhalt der QuelleManshouri, Taghi, Zeev Estrov, Alfonso Quintas-Cardama, Jorge Cortes, Francis Giles, David Harris, Waldemar Priebe, Hagop Kantarjian und Srdan Verstovsek. „WP1066 Inhibits Growth of Human Cells Carrying the JAK2 V617F Mutation.“ Blood 108, Nr. 11 (16.11.2006): 4885. http://dx.doi.org/10.1182/blood.v108.11.4885.4885.
Der volle Inhalt der QuelleGeorgescu, Maria-Magdalena. „TAMI-32. TEMPOROSPATIAL INVASION AND GENETIC EVOLUTION FROM INFRATENTORIAL TO SUPRATENTORIAL COMPARTMENT IN DIFFUSE MIDLINE GLIOMA“. Neuro-Oncology 22, Supplement_2 (November 2020): ii220. http://dx.doi.org/10.1093/neuonc/noaa215.920.
Der volle Inhalt der QuelleLee, Jeong Seok, Yohan An, Christopher J. Yoon, Jeong Yeon Kim, Kyung Hwan Kim, Alexandra F. Freeman, Jae-Joon Yim et al. „Germline gain-of-function mutation of STAT1 rescued by somatic mosaicism in immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like disorder“. Journal of Allergy and Clinical Immunology 145, Nr. 3 (März 2020): 1017–21. http://dx.doi.org/10.1016/j.jaci.2019.11.028.
Der volle Inhalt der QuelleMikulasova, Aneta, Brian A. Walker, Christopher P. Wardell, Eileen M. Boyle, Alexander Murison, Zuzana Kufova, Ludek Pour, Petr Kuglik, Roman Hajek und Gareth J. Morgan. „Somatic Mutation Spectrum in Monoclonal Gammopathy of Undetermined Significance Compared to Multiple Myeloma“. Blood 124, Nr. 21 (06.12.2014): 3346. http://dx.doi.org/10.1182/blood.v124.21.3346.3346.
Der volle Inhalt der QuelleNagata, Yasunobu, Terukazu Enami, Kenji Kontani, Keisuke Kataoka, Mamiko Sakata-Yanagimoto, Akira Kitanaka, Aiko Sato et al. „Novel Biological Effects and Distinct Patterns of Rhoa Mutations in Adult T-Cell Leukemia/Lymphoma and Angioimmunoblastic T Cell Lymphoma“. Blood 124, Nr. 21 (06.12.2014): 2215. http://dx.doi.org/10.1182/blood.v124.21.2215.2215.
Der volle Inhalt der QuelleNothiger, R., M. Jonglez, M. Leuthold, P. Meier-Gerschwiler und T. Weber. „Sex determination in the germ line of Drosophila depends on genetic signals and inductive somatic factors“. Development 107, Nr. 3 (01.11.1989): 505–18. http://dx.doi.org/10.1242/dev.107.3.505.
Der volle Inhalt der QuelleNiemöller, Christoph, Sabine Bleul, Nadja Blagitko-Dorfs, Christine Greil, Kenichi Yoshida, Rainer Claus, Dietmar Pfeifer, Seishi Ogawa, Michael Lübbert und Heiko Becker. „Single Cell Genotyping of Inv(16) AML in CBL Mutated Clonal Hematopoiesis Characterizes Clonal Architecture and Evolution of Exome Sequencing-Identified Mutations in the Protein Tyrosine Phosphatase Ptprt and Other Genes“. Blood 126, Nr. 23 (03.12.2015): 3834. http://dx.doi.org/10.1182/blood.v126.23.3834.3834.
Der volle Inhalt der QuelleSingh, Manu, Raymond Louie, Claire Milthopre, Thiruni Adikari, Melinda Hardy, Megan Faulks, Matt Field et al. „Multi-omic profiling in coeliac disease reveals somatic driver mutations in rogue T cell clones“. Journal of Immunology 210, Nr. 1_Supplement (01.05.2023): 234.12. http://dx.doi.org/10.4049/jimmunol.210.supp.234.12.
Der volle Inhalt der QuelleMaterna-Kiryluk, Anna, Agnieszka Pollak, Karol Gawalski, Aleksandra Szczawinska-Poplonyk, Zuzanna Rydzynska, Anna Sosnowska, Bożena Cukrowska et al. „Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy“. Human Molecular Genetics 30, Nr. 3-4 (30.01.2021): 226–33. http://dx.doi.org/10.1093/hmg/ddab035.
Der volle Inhalt der QuelleMakishima, Kenichi, Kashima Yukie, Yuta Kuze, Sakurako Suma, Yoshiaki Abe, Yasuhito Suehara, Tatsuhiro Sakamoto et al. „Investigation of Clonal Hematopoiesis in New Japanese Cohort“. Blood 142, Supplement 1 (28.11.2023): 5608. http://dx.doi.org/10.1182/blood-2023-181324.
Der volle Inhalt der QuelleAl-Dewik, Nader I., Bruno Cassinat, Jean-Jacques Kiladjian, Alexander Knuth und Mohamed A. Yassin. „Targeted Exome Sequencing Identifies Novel Mutations in Familial Myeloproliferative Neoplasms Patients in the State of Qatar“. Blood 124, Nr. 21 (06.12.2014): 5570. http://dx.doi.org/10.1182/blood.v124.21.5570.5570.
Der volle Inhalt der QuelleStockklausner, Clemens, Christin Maria Duffert, Ziwei Zhou, Anne Christine Klotter, Isabelle Nadine Kuhlee und Andreas E. Kulozik. „Mpl Gain-of-Function Mutations Can be Classified By Differential Subcellular Processing, Molecular Mechanisms, Mode of Inheritance and Clinical Impact“. Blood 126, Nr. 23 (03.12.2015): 1634. http://dx.doi.org/10.1182/blood.v126.23.1634.1634.
Der volle Inhalt der QuelleSanders, Mathijs A., Annelieke Zeilemakers, Jasper Koenders, Remco Hoogenboezem, François Kavelaars, Rob Henderson, Bob Lowenberg und Peter J. M. Valk. „The Gene Encoding Nuclear Erythroid Factor 2 (NFE2) Is Recurrently Mutated in Acute Myeloid Leukemia“. Blood 120, Nr. 21 (16.11.2012): 1392. http://dx.doi.org/10.1182/blood.v120.21.1392.1392.
Der volle Inhalt der QuellePrzychodzen, Bartlomiej, und Sandra Paulina Smieszek. „Preclinical evaluation of JAK2 specific investigational oligonucleotide for the treatment of MDS/PV.“ JCO Global Oncology 9, Supplement_1 (August 2023): 122. http://dx.doi.org/10.1200/go.2023.9.supplement_1.122.
Der volle Inhalt der QuelleCoppe, Alessandro, Emma I. Andersson, Andrea Binatti, Vanessa R. Gasparini, Sabrina Bortoluzzi, Michael J. Clemente, Marco Herling, Jaroslaw P. Maciejewski, Satu Mustjoki und Stefania Bortoluzzi. „Subset-Specific Recurrence of Mutations and Identification of Functional Modules Provides New Clues about the Pathogenesis of Large Granular Lymphocyte Leukemia“. Blood 128, Nr. 22 (02.12.2016): 4117. http://dx.doi.org/10.1182/blood.v128.22.4117.4117.
Der volle Inhalt der QuelleTakeda, Yusuke, Chiaki Nakaseko, Hiroaki Tanaka, Masahiro Takeuchi, Makiko Yui, Atsunori Saraya, Satoru Miyagi et al. „Direct Activation of STAT5 by TEL-Lyn Fusion Protein Promotes Induction of Myeloproliferative Neoplasms with Myelofibrosis“. Blood 116, Nr. 21 (19.11.2010): 4114. http://dx.doi.org/10.1182/blood.v116.21.4114.4114.
Der volle Inhalt der QuelleMambet, Cristina, Jean-Philippe Defour, Olga Babosova, Emilie Leroy, Laura Necula, Oana Stanca, Aurelia Tatic et al. „JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils“. Blood 132, Supplement 1 (29.11.2018): 3066. http://dx.doi.org/10.1182/blood-2018-99-117019.
Der volle Inhalt der QuellePrzychodzen, Bart, Sandra P. Smieszek, Christos M. Polymeropoulos, Mihael Polymeropoulos und Gunther Birznieks. „Preclinical Evaluation of JAK2 Specific Investigational Oligonucleotide for the Treatment of MPNs“. Blood 142, Supplement 1 (28.11.2023): 7138. http://dx.doi.org/10.1182/blood-2023-183035.
Der volle Inhalt der QuelleLukes, Julius, Petr Danek, Oriol Alejo, Eliska Potuckova, Ondrej Gahura, Dirk Heckl, Julia Starkova et al. „Characterization of a Novel JAK1 Pseudokinase Mutation in the First Case of Trisomy 21-Independent GATA1-Mutated Transient Abnormal Myelopoiesis“. Blood 134, Supplement_1 (13.11.2019): 4208. http://dx.doi.org/10.1182/blood-2019-122168.
Der volle Inhalt der QuelleHartert, Keenan, Saber Tadros, Alyssa Bouska, Dalia Moore, Christine Pak, Tayla Heavican, Chih Long Liu et al. „DNA Copy Number Gains of TCF4 (E2-2) Are Associated with Poor Outcome in Diffuse Large B-Cell Lymphoma“. Blood 128, Nr. 22 (02.12.2016): 2686. http://dx.doi.org/10.1182/blood.v128.22.2686.2686.
Der volle Inhalt der QuelleChapuy, Bjoern, Chip Stewart, Andrew Dunford, Jaegil Kim, Kirsty Wienand, Atanas Kamburov, Gabriel Kenneth Griffin et al. „Comprehensive Genomic Analysis of Primary Mediastinal B-Cell Lymphoma“. Blood 132, Supplement 1 (29.11.2018): 1564. http://dx.doi.org/10.1182/blood-2018-99-118135.
Der volle Inhalt der QuellePapayannidis, Cristina, Anna Ferrari, Stefania Paolini, Carmen Baldazzi, Chiara Sartor, Abbenante maria Chiara, Giovanni Marconi et al. „Very Poor Outcome and Chemoresistance of Acute Myeloid Leukemia Patients with TP53 Mutations: Correlation with Complex Karyotype and Clinical Outcome“. Blood 124, Nr. 21 (06.12.2014): 484. http://dx.doi.org/10.1182/blood.v124.21.484.484.
Der volle Inhalt der QuelleGopisetty, Apurva, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall et al. „Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing“. Cancer Research 83, Nr. 7_Supplement (04.04.2023): 234. http://dx.doi.org/10.1158/1538-7445.am2023-234.
Der volle Inhalt der QuelleCasolari, Debora A., Diana G. Iarossi, Carolyn M. Butcher, Sarah C. Bray, Wendy T. Parker, Chris N. Hahn, Susan Branford et al. „Aberrant Activation of Epidermal Growth Factor Receptor in MPN May Respond to the Kinase Inhibitor Gefitinib“. Blood 124, Nr. 21 (06.12.2014): 1882. http://dx.doi.org/10.1182/blood.v124.21.1882.1882.
Der volle Inhalt der QuellePalomero, Teresa, Lucile Couronne, Hossein Khiabanian, Mi-Yeon Kim, Alberto Ambesi, Zachary Carpenter, Francesco Abate et al. „Recurrent Rhoa Mutations In Peripheral T-Cell Lymphoma“. Blood 122, Nr. 21 (15.11.2013): 846. http://dx.doi.org/10.1182/blood.v122.21.846.846.
Der volle Inhalt der QuelleYen, Katharine, Fang Wang, Jeremy Travins, Yue Chen, Hua Yang, Kim Straley, Sung Choe et al. „AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model“. Blood 122, Nr. 21 (15.11.2013): 240. http://dx.doi.org/10.1182/blood.v122.21.240.240.
Der volle Inhalt der QuelleBiancon, Giulia, Poorval Joshi, Torben Hunck, Yimeng Gao, Valentina Botti, Ashley Qin, Mukhtar Sadykov et al. „U2AF1 Driver Mutations in Hematopoietic Disorders Alter but Do Not Abrogate RNA Binding and Enlighten Structural Dependencies of the U2AF-RNA Complex“. Blood 134, Supplement_1 (13.11.2019): 1230. http://dx.doi.org/10.1182/blood-2019-130759.
Der volle Inhalt der QuelleAndersson, Emma I., Samuli Eldfors, Hanna L. M. Koskela, Pekka Ellonen, Thomas Olson, Andres Jerez, Michael J. Clemente et al. „Somatic PTPRT and ANGPT2 Mutations in Large Granulocyte Leukemia“. Blood 120, Nr. 21 (16.11.2012): 1302. http://dx.doi.org/10.1182/blood.v120.21.1302.1302.
Der volle Inhalt der QuelleSoekojo, Cinnie Yentia, Tae-Hoon Chung, Muhammad Shaheryar Furqan und Wee-Joo Chng. „Identifying the Genomic Profile of Functional High-Risk Multiple Myeloma Patients“. Blood 136, Supplement 1 (05.11.2020): 51–52. http://dx.doi.org/10.1182/blood-2020-136553.
Der volle Inhalt der QuelleWillekens, Christophe, Lucie Laplane, Tracy Dagher, Camélia Benlabiod, Catherine Lacout, Philippe Rameau, Cyril Catelain et al. „SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes“. Blood 138, Supplement 1 (05.11.2021): 2544. http://dx.doi.org/10.1182/blood-2021-149757.
Der volle Inhalt der QuelleSong, Jihyun, und Josef T. Prchal. „Ropeginterferon Alfa-2b Blunts Hyperactive JAK2 Activity in Polycythemia Vera and Essential Thrombocythemia“. Blood 142, Supplement 1 (28.11.2023): 3162. http://dx.doi.org/10.1182/blood-2023-190172.
Der volle Inhalt der QuelleMagee, Jeffrey A., Shaina Porter und Andrew Cluster. „FLT3-ITD Has Developmental Context Specific Effects on Hematopoiesis and Myeloid Leukemogenesis“. Blood 126, Nr. 23 (03.12.2015): 843. http://dx.doi.org/10.1182/blood.v126.23.843.843.
Der volle Inhalt der QuelleCline, Thomas W. „A FEMALE-SPECIFIC LETHAL LESION IN AN X-LINKED POSITIVE REGULATOR OF THE DROSOPHILA SEX DETERMINATION GENE, SEX-LETHAL“. Genetics 113, Nr. 3 (01.07.1986): 641–63. http://dx.doi.org/10.1093/genetics/113.3.641.
Der volle Inhalt der QuelleWang, Linghua, Sabina Swierczek, Kimberly Hickman, Soo-Jin Kim, David A. Wheeler und Josef Prchal. „Molecular Characterization Of Polycythemia Vera Based On The Relationship Of JAK2V617F and 9pUPD“. Blood 122, Nr. 21 (15.11.2013): 1607. http://dx.doi.org/10.1182/blood.v122.21.1607.1607.
Der volle Inhalt der QuelleMorgan, Elizabeth A., Mark N. Lee, Daniel J. DeAngelo, David P. Steensma, Richard M. Stone, Frank C. Kuo, Jon C. Aster, Christopher J. Gibson und R. Coleman Lindsley. „Systematic STAT3 Mutation Testing Identifies Patients with Unsuspected T-Cell Large Granular Lymphocytic Leukemia“. Blood 128, Nr. 22 (02.12.2016): 919. http://dx.doi.org/10.1182/blood.v128.22.919.919.
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