Thematische Bibliographien / SncRNA silencing

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  1. Zeitschriftenartikel
  2. Dissertationen

Auswahl der wissenschaftlichen Literatur zum Thema „SncRNA silencing“

Autor: Grafiati
Veröffentlicht am 25. Mai 2024

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Zeitschriftenartikel zum Thema "SncRNA silencing"

1

Carmi, Ofira, Yosef Gotlieb, Yonat Shemer-Avni, and Zvi Bentwich. "The Role of HIV-1-Encoded microRNAs in Viral Replication." Microorganisms 12, no. 3 (2024): 425. http://dx.doi.org/10.3390/microorganisms12030425.

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microRNAs (miRNAs) are small non-coding RNAs (sncRNAs) that play an important role in the life cycle of human viruses. We sought to characterize human immunodeficiency virus 1 (HIV-1)-encoded miRNAs and determine their role in viral replication. Initially, a bioinformatic analysis was used to predict HIV-1-encoded miRNAs. Next, a representative number of these predicted sequences were verified using a miRNA microarray chip, reverse transcription PCR (RT-PCR), and the deep sequencing of RNA extracted from HIV-1-infected cells. Eight HIV-1-encoded sncRNA sequences conforming to the criteria that
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Alsaadi, Mohammed, Muhammad Yasir Khan, Mahmood Hassan Dalhat, et al. "Dysregulation of miRNAs in DLBCL: Causative Factor for Pathogenesis, Diagnosis and Prognosis." Diagnostics 11, no. 10 (2021): 1739. http://dx.doi.org/10.3390/diagnostics11101739.

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MicroRNA is a small non-coding RNA (sncRNA) involved in gene silencing and regulating post-transcriptional gene expression. miRNAs play an essential role in the pathogenesis of numerous diseases, including diabetes, cardiovascular diseases, viral diseases and cancer. Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin’s lymphoma (NHL), arising from different stages of B-cell differentiation whose pathogenesis involves miRNAs. Various viral and non-viral vectors are used as a delivery vehicle for introducing specific miRNA inside the cell. Adenoviruses are linear, double-stranded
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Di Fazio, Arianna, Margarita Schlackow, Sheng Kai Pong, Adele Alagia, and Monika Gullerova. "Dicer dependent tRNA derived small RNAs promote nascent RNA silencing." Nucleic Acids Research 50, no. 3 (2022): 1734–52. http://dx.doi.org/10.1093/nar/gkac022.

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Abstract In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves the cleavage of target messenger RNA (mRNA) or inhibition of translation in the cytoplasm, and transcriptional gene silencing (TGS), which is mediated by the establishment of repressive epigenetic marks at target loci. Transfer RNAs (tRNAs), which are essential for translation, can be processed into small ncRNAs, termed tRNA-derived small RNAs (tsRNAs). The biogenes
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Huang, Songqian, Kazutoshi Yoshitake, and Shuichi Asakawa. "A Review of Discovery Profiling of PIWI-Interacting RNAs and Their Diverse Functions in Metazoans." International Journal of Molecular Sciences 22, no. 20 (2021): 11166. http://dx.doi.org/10.3390/ijms222011166.

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PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs (sncRNAs) that perform crucial biological functions in metazoans and defend against transposable elements (TEs) in germ lines. Recently, ubiquitously expressed piRNAs were discovered in soma and germ lines using small RNA sequencing (sRNA-seq) in humans and animals, providing new insights into the diverse functions of piRNAs. However, the role of piRNAs has not yet been fully elucidated, and sRNA-seq studies continue to reveal different piRNA activities in the genome. In this review, we summarize a set of simplified processes
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Shen, Dong-Fang, Hui-Ping Qi, Wei-Na Zhang, and Wen-Xu Sang. "Resveratrol Promotes Autophagy to Improve neuronal Injury in Parkinson’s Disease by Regulating SNHG1/miR-128-3p/SNCA Axis." Brain Sciences 13, no. 8 (2023): 1124. http://dx.doi.org/10.3390/brainsci13081124.

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Background: Parkinson’s disease (PD) is seriously threatening the health and life quality of the elderly, who have a high incidence and high disability rate. Resveratrol (RES) was reported to play a protective role in PD. However, the functions and potential mechanism of RES in PD remain unclear, which need to be further explored. Methods: Human neuroblastoma cells (SH-SY5Y and SK-N-SH) were subjected to 1-Methyl-4-phenylpyridium (MPP+) induction to construct a cell model of PD. Cell viability was evaluated using CCK-8. The gene expression was evaluated using qRT-PCR and western blot. Lucifera
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Chowdhury, Anisa, and Anto P. Rajkumar. "Systematic review of gene expression studies in people with Lewy body dementia." Acta Neuropsychiatrica 32, no. 6 (2020): 281–92. http://dx.doi.org/10.1017/neu.2020.13.

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AbstractObjectives:Lewy body dementia (LBD) is the second most prevalent neurodegenerative dementia and it causes more morbidity and mortality than Alzheimer’s disease. Several genetic associations of LBD have been reported and their functional implications remain uncertain. Hence, we aimed to do a systematic review of all gene expression studies that investigated people with LBD for improving our understanding of LBD molecular pathology and for facilitating discovery of novel biomarkers and therapeutic targets for LBD.Methods:We systematically reviewed five online databases (PROSPERO protocol
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Ryskalin, Larisa, Rosangela Ferese, Gabriele Morucci, et al. "Occurrence of Total and Proteinase K-Resistant Alpha-Synuclein in Glioblastoma Cells Depends on mTOR Activity." Cancers 14, no. 6 (2022): 1382. http://dx.doi.org/10.3390/cancers14061382.

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Alpha-synuclein (α-syn) is a protein considered to be detrimental in a number of degenerative disorders (synucleinopathies) of which α-syn aggregates are considered a pathological hallmark. The clearance of α-syn strongly depends on autophagy, which can be stimulated by inhibiting the mechanistic target of rapamycin (mTOR). Thus, the overexpression of mTOR and severe autophagy suppression may produce α-syn accumulation, including the proteinase K-resistant protein isoform. Glioblastoma multiforme (GBM) is a lethal brain tumor that features mTOR overexpression and severe autophagy inhibition. C
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Smith, Chase H., Raquel Mejia-Trujillo, Sophie Breton, Brendan J. Pinto, Mark Kirkpatrick, and Justin C. Havird. "Mitonuclear sex determination? Empirical evidence from bivalves." Molecular Biology and Evolution, November 3, 2023. http://dx.doi.org/10.1093/molbev/msad240.

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Abstract Genetic elements encoded in nuclear DNA determine the sex of an individual in many animals. In certain bivalve lineages that possess doubly uniparental inheritance (DUI), mitochondrial DNA (mtDNA) has been hypothesized to contribute to sex determination. In these cases, females transmit a female mtDNA to all offspring, while male mtDNA (M mtDNA) is transmitted only from fathers to sons. Because M mtDNA is inherited in the same way as Y chromosomes, it has been hypothesized that mtDNA may be responsible for sex determination. However, the role of mitochondrial and nuclear genes in sex
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Weigert, Nina, Anna-Lena Schweiger, Jonas Gross, et al. "Detection of a 7SL RNA-derived small non-coding RNA using Molecular Beacons in vitro and in cells." Biological Chemistry, August 28, 2023. http://dx.doi.org/10.1515/hsz-2023-0185.

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Abstract Small non-coding RNAs (sncRNA) are involved in many steps of the gene expression cascade and regulate processing and expression of mRNAs by the formation of ribonucleoprotein complexes (RNP) such as the RNA-induced silencing complex (RISC). By analyzing small RNA Seq data sets, we identified a sncRNA annotated as piR-hsa-1254, which is likely derived from the 3′-end of 7SL RNA2 (RN7SL2), herein referred to as snc7SL RNA. The 7SL RNA is an abundant long non-coding RNA polymerase III transcript and serves as structural component of the cytoplasmic signal recognition particle (SRP). To e
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Huang, Songqian, Shinya Nishiumi, Md Asaduzzaman, et al. "Exosome-derived small non-coding RNAs reveal immune response upon grafting transplantation in Pinctada fucata (Mollusca)." Open Biology 12, no. 5 (2022). http://dx.doi.org/10.1098/rsob.210317.

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Exosomes, a subset of small extracellular vesicles, carry various nucleic acids, proteins, lipids, amino acids and metabolites. They function as a mode of intercellular communication and molecular transfer. Exosome cargo molecules, including small non-coding RNAs (sncRNAs), are involved in the immune response in various organisms. However, the role of exosome-derived sncRNAs in immune responses in molluscs remains unclear. Here, we aimed to reveal the sncRNAs involved in the immune response during grafting transplantation by the pearl oyster Pinctada fucata . Exosomes were successfully extract
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Dissertationen zum Thema "SncRNA silencing"

1

Gospodinova, Dimitrova Dilyana. "Functions of tRNA methyltransferases in the small non-coding RNA pathways and intellectual disability." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS384.

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La 2’-O-methylation (Nm) peut affecter les ARNs de multiples façons et les enzymes qui la déposent sont évolutivement conservées. Leurs mutations sont souvent liées à des cancers et des maladies du cerveau. FTSJ1, une ARNt-methyltransferase (Nm-MTase), associée à la déficience intellectuelle (DI) chez l’Homme et conservée chez la levure, est un excellent exemple. Au cours de mon travail doctoral j’ai démontré la fonction moléculaire de ses homologues prédits de Drosophila (Trm7_32 et Trm7_34) en utilisant la technique de pointe RiboMethSeq, ainsi que le MALDI-TOF. J'ai également découvert de n
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