Zeitschriftenartikel zum Thema „Small inhibitory compounds“
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Alvarez-Gonzalez, Juan Antonio, Robert Maul, Rahul M. Kohli und Patricia J. Gearhart. „Small molecule inhibitors of Activation-Induced Deaminase“. Journal of Immunology 200, Nr. 1_Supplement (01.05.2018): 48.18. http://dx.doi.org/10.4049/jimmunol.200.supp.48.18.
Der volle Inhalt der QuelleYan, Hua, Tomoko Chiba Mizutani, Nobuhiko Nomura, Tadakazu Takakura, Yoshihiro Kitamura, Hideka Miura, Masako Nishizawa, Masashi Tatsumi, Naoki Yamamoto und Wataru Sugiura. „A Novel Small Molecular Weight Compound with a Carbazole Structure That Demonstrates Potent Human Immunodeficiency Virus Type-1 Integrase Inhibitory Activity“. Antiviral Chemistry and Chemotherapy 16, Nr. 6 (Dezember 2005): 363–73. http://dx.doi.org/10.1177/095632020501600603.
Der volle Inhalt der QuelleAsai, Takashi, Tsutomu Takeuchi, Jeff Diffenderfer und L. David Sibley. „Identification of Small-Molecule Inhibitors of Nucleoside Triphosphate Hydrolase in Toxoplasma gondii“. Antimicrobial Agents and Chemotherapy 46, Nr. 8 (August 2002): 2393–99. http://dx.doi.org/10.1128/aac.46.8.2393-2399.2002.
Der volle Inhalt der QuellePatkar, Chinmay G., Martha Larsen, Michael Owston, Janet L. Smith und Richard J. Kuhn. „Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay“. Antimicrobial Agents and Chemotherapy 53, Nr. 10 (03.08.2009): 4103–14. http://dx.doi.org/10.1128/aac.00074-09.
Der volle Inhalt der QuelleHan, Chun, Jiahong Ren, Feng Su, Xiaoqin Hu, Mengyao Li, Zhijun Wang und Lintao Wu. „Hybrids of Quinoline and Anilinopyrimidine: Novel EGFRT790M Inhibitors with Antiproliferative Activity against Non-Small Cell Lung Cancer Cell Lines“. Anti-Cancer Agents in Medicinal Chemistry 20, Nr. 6 (14.06.2020): 724–33. http://dx.doi.org/10.2174/1871520620666200302113206.
Der volle Inhalt der QuelleAbramić, Marija, und Dejan Agić. „Survey of Dipeptidyl Peptidase III Inhibitors: From Small Molecules of Microbial or Synthetic Origin to Aprotinin“. Molecules 27, Nr. 9 (07.05.2022): 3006. http://dx.doi.org/10.3390/molecules27093006.
Der volle Inhalt der QuelleNoueiry, Amine O., Paul D. Olivo, Urszula Slomczynska, Yi Zhou, Ben Buscher, Brian Geiss, Michael Engle et al. „Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection“. Journal of Virology 81, Nr. 21 (22.08.2007): 11992–2004. http://dx.doi.org/10.1128/jvi.01358-07.
Der volle Inhalt der QuelleLefas, Georgia, und George Chaconas. „High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete“. Antimicrobial Agents and Chemotherapy 53, Nr. 10 (13.07.2009): 4441–49. http://dx.doi.org/10.1128/aac.00529-09.
Der volle Inhalt der QuelleErcan-Fang, Nacide, Miriam R. Taylor, Judith L. Treadway, Carolyn B. Levy, Paul E. Genereux, E. Michael Gibbs, Virginia L. Rath, Younggil Kwon, Mary C. Gannon und Frank Q. Nuttall. „Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors“. American Journal of Physiology-Endocrinology and Metabolism 289, Nr. 3 (September 2005): E366—E372. http://dx.doi.org/10.1152/ajpendo.00264.2004.
Der volle Inhalt der QuelleYoo, Jihye, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo und Hyun Ae Woo. „Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β“. Molecules 27, Nr. 9 (22.04.2022): 2696. http://dx.doi.org/10.3390/molecules27092696.
Der volle Inhalt der QuelleRamesh, Priyanka, und Shanthi Veerappapillai. „Designing Novel Compounds for the Treatment and Management of RET-Positive Non-Small Cell Lung Cancer—Fragment Based Drug Design Strategy“. Molecules 27, Nr. 5 (28.02.2022): 1590. http://dx.doi.org/10.3390/molecules27051590.
Der volle Inhalt der QuelleGong, Mengdie, Mingyan Tu, Hongxia Sun, Lu Li, Lili Zhu, Honglin Li, Zhenjiang Zhao und Shiliang Li. „Design, Synthesis, and Structure–Activity Relationship Study of Potent MAPK11 Inhibitors“. Molecules 27, Nr. 1 (29.12.2021): 203. http://dx.doi.org/10.3390/molecules27010203.
Der volle Inhalt der QuelleTian, Tao, Guo-Ying Chen, Hao Zhang und Feng-Qing Yang. „Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose“. Molecules 26, Nr. 15 (30.07.2021): 4638. http://dx.doi.org/10.3390/molecules26154638.
Der volle Inhalt der QuelleFlaumenhaft, Robert, Lynn VerPlank, James R. Dilks, Price S. Blair, Albert Mairuhu, Joseph Negri, Jason Burbank et al. „A Chemical Genetic Analysis of Platelet Activation.“ Blood 114, Nr. 22 (20.11.2009): 4009. http://dx.doi.org/10.1182/blood.v114.22.4009.4009.
Der volle Inhalt der QuelleChoi, Ryan, Mowei Zhou, Roger Shek, Jesse W. Wilson, Logan Tillery, Justin K. Craig, Indraneel A. Salukhe et al. „High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity“. PLOS ONE 16, Nr. 4 (22.04.2021): e0250019. http://dx.doi.org/10.1371/journal.pone.0250019.
Der volle Inhalt der QuelleRuseva, Nina, Hristina Sbirkova-Dimitrova, Mariyana Atanasova, Ana Marković, Žaklina Šmelcerović, Andrija Šmelcerović, Adriana Bakalova und Emiliya Cherneva. „Synthesis and DNase I Inhibitory Properties of New Squaramides“. Molecules 28, Nr. 2 (05.01.2023): 538. http://dx.doi.org/10.3390/molecules28020538.
Der volle Inhalt der QuelleHuang, Yuting, Zhaoxing Li, Yuan Ma, Qianqian Wu, Jianping Kong, Lijuan Zhao, Shunxiang Li und Juan Li. „Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism Prediction“. Pharmaceuticals 17, Nr. 3 (01.03.2024): 325. http://dx.doi.org/10.3390/ph17030325.
Der volle Inhalt der QuelleSato, Yoshiaki, Ikuo Kashiwakura, Masaru Yamaguchi, Hironori Yoshino, Takeshi Tanaka, Ken Ikeda, Zhengmao Ye, Hirotsugu Komatsu, Takao Matsuzaki und Masato Hosoda. „Discovery of a Novel Small-molecule Interleukin-6 Inhibitor Through Virtual Screening Using Artificial Intelligence“. Medicinal Chemistry 18, Nr. 6 (Juli 2022): 694–700. http://dx.doi.org/10.2174/1573406418666211116144243.
Der volle Inhalt der QuellePaiboonrungruang, chorlada. „Abstract 6237: Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia“. Cancer Research 83, Nr. 7_Supplement (04.04.2023): 6237. http://dx.doi.org/10.1158/1538-7445.am2023-6237.
Der volle Inhalt der QuelleJiang, Suping, Sean T. Prigge, Lan Wei, Yu-e. Gao, Thomas H. Hudson, Lucia Gerena, John B. Dame und Dennis E. Kyle. „New Class of Small Nonpeptidyl Compounds BlocksPlasmodium falciparum Development In Vitro by Inhibiting Plasmepsins“. Antimicrobial Agents and Chemotherapy 45, Nr. 9 (01.09.2001): 2577–84. http://dx.doi.org/10.1128/aac.45.9.2577-2584.2001.
Der volle Inhalt der QuelleMoi, Davide, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran und Valentina Onnis. „Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity“. Molecules 27, Nr. 17 (23.08.2022): 5370. http://dx.doi.org/10.3390/molecules27175370.
Der volle Inhalt der QuelleAl-Sanea, Mohammad M. „Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold“. PeerJ 8 (13.03.2020): e8649. http://dx.doi.org/10.7717/peerj.8649.
Der volle Inhalt der QuelleGao, Yinghong, Stephen P. Davies, Martin Augustin, Anna Woodward, Umesh A. Patel, Robert Kovelman und Kevin J. Harvey. „A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery“. Biochemical Journal 451, Nr. 2 (28.03.2013): 313–28. http://dx.doi.org/10.1042/bj20121418.
Der volle Inhalt der QuelleCruz-Migoni, Abimael, Peter Canning, Camilo E. Quevedo, Carole J. R. Bataille, Nicolas Bery, Ami Miller, Angela J. Russell, Simon E. V. Phillips, Stephen B. Carr und Terence H. Rabbitts. „Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds“. Proceedings of the National Academy of Sciences 116, Nr. 7 (25.01.2019): 2545–50. http://dx.doi.org/10.1073/pnas.1811360116.
Der volle Inhalt der QuelleRamshini, Hassan, Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi und Fabrizio Chiti. „Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation“. International Journal of Molecular Sciences 20, Nr. 22 (07.11.2019): 5558. http://dx.doi.org/10.3390/ijms20225558.
Der volle Inhalt der QuelleMinhas, Richa, und Yogita Bansal. „iNOS inhibitors: Benzimidazole-coumarin derivatives to combat inflammation“. European Journal of Chemistry 13, Nr. 3 (30.09.2022): 307–18. http://dx.doi.org/10.5155/eurjchem.13.3.307-318.2282.
Der volle Inhalt der QuelleChattopadhyay, Shrikanta, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Leigh Carmody et al. „Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma“. Blood 120, Nr. 21 (16.11.2012): 571. http://dx.doi.org/10.1182/blood.v120.21.571.571.
Der volle Inhalt der QuelleAdachi, Ryutaro, Tsuyoshi Ishii, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto und Tomohiro Kawamoto. „Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry“. SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, Nr. 4 (08.10.2016): 360–65. http://dx.doi.org/10.1177/1087057116673181.
Der volle Inhalt der QuelleMavridis, Evangelos, Eleftherios Bermperoglou, Eleni Pontiki und Dimitra Hadjipavlou-Litina. „5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules“. Molecules 25, Nr. 14 (11.07.2020): 3173. http://dx.doi.org/10.3390/molecules25143173.
Der volle Inhalt der QuelleTrenholme, Katharine, Linda Marek, Sandra Duffy, Gabriele Pradel, Gillian Fisher, Finn K. Hansen, Tina S. Skinner-Adams et al. „Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules“. Antimicrobial Agents and Chemotherapy 58, Nr. 7 (14.04.2014): 3666–78. http://dx.doi.org/10.1128/aac.02721-13.
Der volle Inhalt der QuelleZhao, Hongchuan, Pu Sun, Wei Guo, Yi Wang, Ao Zhang, Linghua Meng und Chunyong Ding. „Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product“. Molecules 24, Nr. 6 (18.03.2019): 1059. http://dx.doi.org/10.3390/molecules24061059.
Der volle Inhalt der QuelleFurbish, Amelia B., Ahmed S. Alford, Pieter Burger, Yuri K. Peterson, Tracy Murray-Stewart, Robert A. Casero und Patrick M. Woster. „Identification and Characterization of Novel Small-Molecule SMOX Inhibitors“. Medical Sciences 10, Nr. 3 (30.08.2022): 47. http://dx.doi.org/10.3390/medsci10030047.
Der volle Inhalt der QuelleVENÄLÄINEN, Jarkko I., Risto O. JUVONEN, J. Arturo GARCIA-HORSMAN, Erik A. A. WALLÉN, Johannes A. M. CHRISTIAANS, Elina M. JARHO, Jukka GYNTHER und Pekka T. MÄNNISTÖ. „Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site“. Biochemical Journal 382, Nr. 3 (07.09.2004): 1003–8. http://dx.doi.org/10.1042/bj20040992.
Der volle Inhalt der QuelleKollár, Levente, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry et al. „Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads“. Cells 10, Nr. 12 (06.12.2021): 3431. http://dx.doi.org/10.3390/cells10123431.
Der volle Inhalt der QuelleNordio, Giulia, Francesco Piazzola, Giorgio Cozza, Monica Rossetto, Manuela Cervelli, Anna Minarini, Filippo Basagni et al. „From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs“. Molecules 28, Nr. 17 (29.08.2023): 6329. http://dx.doi.org/10.3390/molecules28176329.
Der volle Inhalt der QuelleMoon, Sungho, Seon Yeon Cho, Minhye Kim, Soojeong Beak, Jinhyuk Kim, Yongchan Kim, Sungil Park et al. „Abstract B142: Discovery of novel and potent TEAD inhibitors, orally available small molecules with anti-tumor activity in hippo pathway- dysregulated cancers“. Molecular Cancer Therapeutics 22, Nr. 12_Supplement (01.12.2023): B142. http://dx.doi.org/10.1158/1535-7163.targ-23-b142.
Der volle Inhalt der QuelleRusina, Polina, Erik Gandalipov, Yana Abdusheva, Maria Panova, Alexandra Burdenkova, Vasiliy Chaliy, Maria Brachs et al. „Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases“. Cancers 15, Nr. 15 (25.07.2023): 3766. http://dx.doi.org/10.3390/cancers15153766.
Der volle Inhalt der QuelleFrancini, Cinzia, Francesca Musumeci, Anna Fallacara, Lorenzo Botta, Alessio Molinari, Roberto Artusi, Laura Mennuni, Adriano Angelucci und Silvia Schenone. „Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors“. Molecules 23, Nr. 9 (17.09.2018): 2369. http://dx.doi.org/10.3390/molecules23092369.
Der volle Inhalt der QuelleKulkarni, Amol A., Ayyiliath M. Sajith, Changwen Zhang, Jiukuan Hao und J. Phillip Bowen. „Small molecule prevents inflammation in microglia by targeting the NLRP3 inflammasome“. Journal of Immunology 204, Nr. 1_Supplement (01.05.2020): 160.15. http://dx.doi.org/10.4049/jimmunol.204.supp.160.15.
Der volle Inhalt der QuelleRampogu, Shailima, Ayoung Baek, Chanin Park, Shraddha Parate, Saravanan Parameswaran, Yohan Park, Baji Shaik, Ju Hyun Kim, Seok Ju Park und Keun Woo Lee. „Discovery of Small Molecules that Target Vascular Endothelial Growth Factor Receptor-2 Signalling Pathway Employing Molecular Modelling Studies“. Cells 8, Nr. 3 (21.03.2019): 269. http://dx.doi.org/10.3390/cells8030269.
Der volle Inhalt der QuelleGising, Johan, Saman Honarnejad, Maaike Bras, Gemma L. Baillie, Stuart P. McElroy, Philip S. Jones, Angus Morrison, Julia Beveridge, Mathias Hallberg und Mats Larhed. „The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds“. International Journal of Molecular Sciences 25, Nr. 7 (06.04.2024): 4084. http://dx.doi.org/10.3390/ijms25074084.
Der volle Inhalt der QuelleCurreli, Francesca, Shahad Ahmed, Sofia M. B. Victor, Aleksandra Drelich, Siva S. Panda, Andrea Altieri, Alexander V. Kurkin, Chien-Te K. Tseng, Christopher D. Hillyer und Asim K. Debnath. „Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays“. Viruses 14, Nr. 1 (31.12.2021): 69. http://dx.doi.org/10.3390/v14010069.
Der volle Inhalt der QuelleElsawi, Ahmed E., Mai I. Shahin, Hager A. Elbendary, Tarfah Al-Warhi, Fatma E. Hassan und Wagdy M. Eldehna. „1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking“. Pharmaceuticals 17, Nr. 1 (08.01.2024): 81. http://dx.doi.org/10.3390/ph17010081.
Der volle Inhalt der QuellePorubin, Diana. „Inhibition of in Vitro Nitrosation of Nornicotine“. Chemistry Journal of Moldova 2, Nr. 1 (Dezember 2007): 78–82. http://dx.doi.org/10.19261/cjm.2007.02(1).11.
Der volle Inhalt der QuelleMontanari, Floriane, Anna Cseke, Katrin Wlcek und Gerhard F. Ecker. „Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors“. SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, Nr. 1 (11.07.2016): 86–93. http://dx.doi.org/10.1177/1087057116657513.
Der volle Inhalt der QuelleZhang, Hao, Feng-Qing Yang und Jian-Li Gao. „A Simple and Portable Personal Glucose Meter Method Combined with Molecular Docking for Screening of Lipase Inhibitors“. Evidence-Based Complementary and Alternative Medicine 2022 (22.09.2022): 1–9. http://dx.doi.org/10.1155/2022/4430050.
Der volle Inhalt der QuelleAlkhashrom, Sewar, Jintawee Kicuntod, Sigrun Häge, Johannes Schweininger, Yves A. Muller, Peter Lischka, Manfred Marschall und Jutta Eichler. „Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors“. Viruses 13, Nr. 3 (12.03.2021): 471. http://dx.doi.org/10.3390/v13030471.
Der volle Inhalt der QuelleYang, Cheng-Wei, Yung-Ning Yang, Po-Huang Liang, Chi-Min Chen, Wei-Liang Chen, Hwan-You Chang, Yu-Sheng Chao und Shiow-Ju Lee. „Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus“. Antimicrobial Agents and Chemotherapy 51, Nr. 11 (20.08.2007): 3924–31. http://dx.doi.org/10.1128/aac.00408-07.
Der volle Inhalt der QuelleLiargkova, Thalia, Nikolaos Eleftheriadis, Frank Dekker, Efstathia Voulgari, Constantinos Avgoustakis, Marina Sagnou, Barbara Mavroidi, Maria Pelecanou und Dimitra Hadjipavlou-Litina. „Small Multitarget Molecules Incorporating the Enone Moiety“. Molecules 24, Nr. 1 (07.01.2019): 199. http://dx.doi.org/10.3390/molecules24010199.
Der volle Inhalt der QuelleZhang, Yan, und Niefang Yu. „Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors“. Letters in Drug Design & Discovery 17, Nr. 11 (23.10.2020): 1330–41. http://dx.doi.org/10.2174/1570180817999200608140628.
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