Zeitschriftenartikel: „Skin equivalent“

1

Rowling, P. J. E., M. J. Raxworthy, E. J. Wood, J. N. Kearny und W. J. Cunliffe. „Biological skin equivalent“. Burns 15, Nr. 1 (Februar 1989): 64. http://dx.doi.org/10.1016/0305-4179(89)90076-4.

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2

Maruguchi, Tomoko, Yukiya Maruguchi, Shigehiko Suzuki, Kazuya Matsuda, Ken-Ichi Toda und Nobuhiko Isshiki. „A New Skin Equivalent“. Plastic and Reconstructive Surgery 93, Nr. 3 (März 1994): 537–44. http://dx.doi.org/10.1097/00006534-199403000-00014.

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3

Maruguchi, Tomoko, Yukiya Maruguchi, Shigehiko Suzuki, Kazuya Matsuda, Ken-Ichi Toda und Nobuhiko Isshiki. „A New Skin Equivalent“. Plastic and Reconstructive Surgery 93, Nr. 3 (März 1994): 545–46. http://dx.doi.org/10.1097/00006534-199403000-00015.

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4

Maruguchi, Tomoko, Yukiya Maruguchi, Shigehiko Suzuki, Kazuya Matsuda, Ken-Ichi Toda und Nobuhiko Isshiki. „A New Skin Equivalent“. Plastic and Reconstructive Surgery 93, Nr. 3 (März 1994): 537–44. http://dx.doi.org/10.1097/00006534-199493030-00014.

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5

Maruguchi, Tomoko, Yukiya Maruguchi, Shigehiko Suzuki, Kazuya Matsuda, Ken-Ichi Toda und Nobuhiko Isshiki. „A New Skin Equivalent“. Plastic and Reconstructive Surgery 93, Nr. 3 (März 1994): 545–46. http://dx.doi.org/10.1097/00006534-199493030-00015.

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6

Bouvard, Véronique, Lucie Germain, Pierre Rompré, Brigitte Roy und François A. Auger. „Influence of dermal equivalent maturation on the development of a cultured skin equivalent“. Biochemistry and Cell Biology 70, Nr. 1 (01.01.1992): 34–42. http://dx.doi.org/10.1139/o92-005.

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Histologic and immunofluorescence methods were used to analyse the presence of fibronectin, chondroitin-4-sulphate and chondroitin-6-sulphate, type III and IV collagens, laminin, and keratins to assess the maturation level of cultured dermal and skin equivalents. In a first phase, fibroblasts in monolayer culture were compared with dermal equivalents in which fibroblasts are embedded in a type I collagen gel. Different fluorescent patterns were observed depending on the culture system used. A sequential appearance of macromolecules was noticed in dermal equivalents. Fibronectin was first detected after 4 days of culture, whereas chondroitin-4-sulphate and chondroitin-6-sulphate and type III collagen were present after 7 days. In contrast, all three macromolecules were detected at 24 h of culture in fibroblastic monolayer cultures. In a second phase, the quality of our skin equivalents was evaluated according to the seeding time of epidermal cells upon dermal equivalents (1, 4, or 7 days). A satisfactory stratification was obtained when keratinocytes were seeded after 4 and 7 days of dermal equivalent culture. Laminin and fibronectin were detected at the dermo-epidermal junction, but type IV collagen was absent. Various keratins, as detected by the AE1, AE2, and AE3 antibodies, were present in the epidermal layer. Following keratinocyte confluence, a change in the organization pattern of type III collagen in the dermal fraction of the skin equivalent was also noticed. Our comparative results show that seeding of epidermal cells on a more mature dermal equivalent leads to improved differentiation status of the epidermal layer.Key words: collagen lattice, fibroblast, skin equivalent, dermal equivalent, maturation.

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7

Vu Dinh, T., B. Cabon und J. Chilo. „New skin-effect equivalent circuit“. Electronics Letters 26, Nr. 19 (1990): 1582. http://dx.doi.org/10.1049/el:19901015.

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8

De, Sumit K., Ernane D. Reis und Morris D. Kerstein. „Wound Treatment with Human Skin Equivalent“. Journal of the American Podiatric Medical Association 92, Nr. 1 (01.01.2002): 19–23. http://dx.doi.org/10.7547/87507315-92-1-19.

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Skin grafting provides an effective means of closing chronic wounds. Autografts and allografts are used most often in skin grafting, but Apligraf, a tissue-engineered bilayered human skin equivalent, provides another safe and effective grafting option for treating diabetic, venous, and pressure ulcers. This skin equivalent has an epidermis and dermis similar to human skin, largely due to its derivation from neonatal foreskin. Apligraf is also easily accessible and has shown little immunoreactivity. (J Am Podiatr Med Assoc 92(1): 19-23, 2002)

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9

Rogovaya, O. S., E. S. Chermnykh, E. O. Osidak, E. V. Kiseleva, A. L. Rippa, A. A. Ryabinin, A. K. Beilin, N. G. Gurskaya und E. A. Vorotelyak. „RECONSTRUCTION OF FUNCTIONAL EQUIVALENTS OF THE SKIN USING CELL AND TISSUE TECHNOLOGIES“. http://eng.biomos.ru/conference/articles.htm 1, Nr. 19 (2021): 193–94. http://dx.doi.org/10.37747/2312-640x-2021-19-193-194.

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The work is based on obtaining a living skin equivalent based on a three-dimensional scaffold consisting of type I collagen and other components of the extracellular matrix. The composition of the equivalent includes dermal and epidermal cells, it significantly accelerates and normalizes the healing process of chronic wounds. The living equivalent of the skin is a start for the further development of tissue-engineered constructs-analogs of skin and equivalents of other human tissues: at present, in particular, work is underway to study the stromal fractions of the dermis to control epithelial-mesenchymal interactions in vitro.

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10

English, Kathleen B., naida Stayner, Gerald Krueger und Robert P. Tuckett. „Tactile function in skin-equivalent grafts“. Experimental Neurology 115, Nr. 1 (Januar 1992): 104–8. http://dx.doi.org/10.1016/0014-4886(92)90230-n.

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11

Auger, François A., Carlos A. López Valle, Rina Guignard, Nathalie Tremblay, Bernard Noel, Francine Goulet und Lucie Germain. „Skin equivalent produced with human collagen“. In Vitro Cellular & Developmental Biology - Animal 31, Nr. 6 (Juni 1995): 432–39. http://dx.doi.org/10.1007/bf02634255.

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12

Fransson, J., und H. Hammar. „Epidermal growth in the skin equivalent“. Archives of Dermatological Research 284, Nr. 6 (Dezember 1992): 343–48. http://dx.doi.org/10.1007/bf00372037.

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13

Costello, L., K. Goncalves, A. Simpson, L. Smith, M. Freer, V. Maltman, P. De Los Santos Gomez et al. „095 Bioengineering a complex skin equivalent for skin care applications“. Journal of Investigative Dermatology 141, Nr. 5 (Mai 2021): S17. http://dx.doi.org/10.1016/j.jid.2021.02.113.

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14

Bell, E., M. Rosenberg, P. Kemp, R. Gay, G. D. Green, N. Muthukumaran und C. Nolte. „Recipes for Reconstituting Skin“. Journal of Biomechanical Engineering 113, Nr. 2 (01.05.1991): 113–19. http://dx.doi.org/10.1115/1.2891224.

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Reconstituted Living Skin Equivalent™ (LSE™) is made up of a dermal equivalent (DE) on which keratinocytes are plated where they give rise to a multilayered differentiated epidermis. The dermal equivalent develops through interactions between fibroblasts and collagen fibrils that begin to form after the cell-matrix precursor is cast. The gel that forms as a result of collagen polymerization and fluid trapping is contracted uniformly in all dimensions. By securing it at ends and edges in the mold in which it is cast, the final dimensions, strength and morphology of the forming tissue are altered. The same phenomena are seen in casting tubular tissues for the fabrication of small caliber blood vessel equivalents. The cells of the dermal equivalent are biosynthetically active and enrich the matrix to different degrees with secretory products, depending on how the cells are stimulated and on the presence or absence of an epidermis. Collagen biosynthesis by dermal cells in the DE is sensitive to growth factors, ascorbate concentrations and amino acid pools. Both ascorbate and TGFβ1 increase total collagen biosynthesis at least two-fold by one week after tissue formation. With TGFβ1 present, the capacity of cells in the DE to synthesize collagen increases with time, over a two-week period. If ascorbate (200 μg/ml) is added just after the tissue is cast and daily thereafter, contraction lattice is blocked, and collagen biosynthesis is enhanced relative to contracted controls that had received 200 μg/ml ascorbate once. The increase was nearly an order of magnitude over that of controls and was coordinate with a comparable increase in hyaluronate and sulfated glycosaminoglycan (GAG) production as shown by TCA-precipitable glucosamine in the intercellular matrix of the DE. Both the LSE and the Living Dermal Equivalent™ (LDE™) exhibit complex responses to UV radiation and to various chemicals that are greatly different from responses given by monolayered cells. In general, threshold doses are elevated by one or more orders of magnitude for the tissues as compared with cells in monolayer, with the LSE exhibiting higher thresholds than the DE. The immunogenicity of the human LSE has been tested in vitro. Its cells are shown to be unable to stimulate a response in a mixed lymphocyte reaction (MLR) even after Class II antigens are induced by exposure to cytokines. The basis for the immunologic neutrality of the LSE can be referred to the absence of immune system (IS) cells normally present in skin and to the specific antigenic profiles of nonimmune system (NIS) cells that must be different from those of IS cells and which, even after Class II induction, are not allostimulatory. The generality of immunologic neutrality is an essential consideration in the fabrication of tissue and organ equivalents for grafting. The idea that it can be made a graft property has been formalized in the Neutral Allograft Hypothesis.

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15

Lee, Sung, Il-Hong Bae, Paulo Marinho, Chang Lee und Jongsung Lee. „Reduced humidity induces skin barrier dysfunction and secretion of dipeptidyl peptidase-4 (DPP-4) in a skin-equivalent model“. Archives of Biological Sciences 71, Nr. 4 (2019): 697–702. http://dx.doi.org/10.2298/abs190523052l.

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Seasonal changes can affect the physiological condition of the skin and cause various cutaneous disorders. The skin barrier function tends to worsen during winter when humidity is lower compared to other seasons. To determine the influence of relative humidity (RH) on the function of the skin barrier, we performed biological and histological assays using skin equivalents that were cultured under reduced humidity in an environmental humidity chamber. We found that reduced humidity led to decreased epidermal thickness and disruption of the skin barrier. Reduced humidity induced the decrease of filaggrin, loricrin and damage to tight junction. In addition, dipeptidyl peptidase-4 (DPP4), which has roles in the immunological process, was upregulated in a skin-equivalent model under reduced humidity. These results suggest that reduced humidity affects the skin barrier function and regulates the secretion of DPP4 in a skin-equivalent model.

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16

Thappa, Devinder Mohan, und Munisamy Malathi. „Is beauty equivalent of fair/white skin?“ CosmoDerma 2 (11.04.2022): 30. http://dx.doi.org/10.25259/csdm_36_2022.

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17

Brattsand, M. „Missing factors in human skin equivalent models?“ British Journal of Dermatology 176, Nr. 1 (Januar 2017): 11–12. http://dx.doi.org/10.1111/bjd.15108.

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18

Schechner, Jeffrey S., Saara K. Crane, Feiya Wang, Anya M. Szeglin, George Tellides, Marc I. Lorber, Alfred L. M. Bothwell und Jordan S. Pober. „Engraftment of a vascularized human skin equivalent“. FASEB Journal 17, Nr. 15 (Dezember 2003): 2250–56. http://dx.doi.org/10.1096/fj.03-0257com.

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19

Diekmann, Johanna, Lirija Alili, Okka Scholz, Melanie Giesen, Olaf Holtkötter und Peter Brenneisen. „A three-dimensional skin equivalent reflecting some aspects ofin vivoaged skin“. Experimental Dermatology 25, Nr. 1 (23.11.2015): 56–61. http://dx.doi.org/10.1111/exd.12866.

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20

Ademola, John I., Ernest Bloom, Anne E. Maczulak und Howard I. Maibach. „Skin Penetration and Metabolism: Comparative Evaluation of Skin Equivalent, Cell Culture, and Human Skin“. Journal of Toxicology: Cutaneous and Ocular Toxicology 12, Nr. 2 (Januar 1993): 129–38. http://dx.doi.org/10.3109/15569529309036255.

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21

Roy, S. D., J. Fujiki und J. S. Fleitman. „Permeabilities of Alkyl p-Aminobenzoates through Living Skin Equivalent and Cadaver Skin“. Journal of Pharmaceutical Sciences 82, Nr. 12 (Dezember 1993): 1266–68. http://dx.doi.org/10.1002/jps.2600821217.

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22

Schaller-Ammann, Roland, Sebastian Kreß, Jürgen Feiel, Gerd Schwagerle, Joachim Priedl, Thomas Birngruber, Cornelia Kasper und Dominik Egger. „Advanced Online Monitoring of In Vitro Human 3D Full-Thickness Skin Equivalents“. Pharmaceutics 14, Nr. 7 (08.07.2022): 1436. http://dx.doi.org/10.3390/pharmaceutics14071436.

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Skin equivalents and skin explants are widely used for dermal penetration studies in the pharmacological development of drugs. Environmental parameters, such as the incubation and culture conditions affect cellular responses and thus the relevance of the experimental outcome. However, available systems such as the Franz diffusion chamber, only measure in the receiving culture medium, rather than assessing the actual conditions for cells in the tissue. We developed a sampling design that combines open flow microperfusion (OFM) sampling technology for continuous concentration measurements directly in the tissue with microfluidic biosensors for online monitoring of culture parameters. We tested our design with real-time measurements of oxygen, glucose, lactate, and pH in full-thickness skin equivalent and skin explants. Furthermore, we compared dermal penetration for acyclovir, lidocaine, and diclofenac in skin equivalents and skin explants. We observed differences in oxygen, glucose, and drug concentrations in skin equivalents compared to the respective culture medium and to skin explants.

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23

Altman, MI. „Treatment of venous ulcers with human skin equivalent“. Journal of the American Podiatric Medical Association 87, Nr. 8 (01.08.1997): 392–94. http://dx.doi.org/10.7547/87507315-87-8-392.

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In the author's clinical experience in rating venous ulcers, human skin equivalent has been efficacious, safe, cost-effective, and easy to use. This innovation is likely to become an important therapeutic tool for podiatric physicians who treat venous ulcers. Leg ulcers are a large economic burden to society, both in direct and total costs, including patient time lost from work for labor- and time-intensive therapies. The cost-containing measures of the managed care environment encourage treatment of venous ulcers in an outpatient center. Because human skin equivalent can be applied in such a setting, podiatric physicians will be able to treat venous ulcers routinely without referring patients to more costly settings such as hospitals or surgical centers. Because human skin equivalent is an effective alternative to standard venous ulcer therapies, this agent, which is currently under review by the Food and Drug Administration, should provide a viable treatment that may reduce the total costs associated with venous ulcer care.

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24

Serra, Montserrat, Pilar Brazís, Anna Puigdemont, Dolors Fondevila, Víctor Romano, Celina Torre und Lluís Ferrer. „Development and characterization of a canine skin equivalent“. Experimental Dermatology 16, Nr. 2 (Februar 2007): 135–42. http://dx.doi.org/10.1111/j.1600-0625.2006.00525.x.

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25

de Breij, Anna, Elisabeth M. Haisma, Marion Rietveld, Abdelouahab El Ghalbzouri, Peterhans J. van den Broek, Lenie Dijkshoorn und Peter H. Nibbering. „Three-Dimensional Human Skin Equivalent as a Tool To Study Acinetobacter baumannii Colonization“. Antimicrobial Agents and Chemotherapy 56, Nr. 5 (30.01.2012): 2459–64. http://dx.doi.org/10.1128/aac.05975-11.

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ABSTRACTAcinetobacter baumanniican colonize body surfaces of hospitalized patients. From these sites, invasion into the host and spread to other patients and the hospital environment may occur. The eradication of the organism from the patient's skin is an important infection control strategy during epidemic and endemic episodes. In this study, a three-dimensional (3D), air-exposed human epidermal skin equivalent was exploited to studyAcinetobacterskin colonization. We characterized the adherence ofA. baumanniiATCC 19606TandAcinetobacter juniiRUH2228Tto and biofilm formation on the skin equivalent and the responses to these bacteria. Furthermore, we assessed the ability of the disinfectant chlorhexidine to decolonize the skin equivalents. The results revealed that both strains replicated on the stratum corneum for up to 72 h but did not invade the epidermis.A. baumannii, in contrast toA. junii, formed large biofilms on the stratum corneum. Bacterial colonization did not affect keratinocyte activation, proliferation, or differentiation, nor did it induce a strong inflammatory response. Disinfection with chlorhexidine solution resulted in complete eradication ofA. baumanniifrom the skin, without detrimental effects. This 3D model is a promising tool to study skin colonization and to evaluate the effects of novel disinfectant and antimicrobial strategies.

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Augustin, C., C. Collombel und O. Damour. „Use of dermal equivalent and skin equivalent models for identifying phototoxic compounds in vitro“. Photodermatology, Photoimmunology & Photomedicine 13, Nr. 1-2 (04.02.1997): 27–36. http://dx.doi.org/10.1111/j.1600-0781.1997.tb00105.x.

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27

Cerrato, S., L. Ramió-Lluch, D. Fondevila, D. Rodes, P. Brazis und A. Puigdemont. „Effects of Essential Oils and Polyunsaturated Fatty Acids on Canine Skin Equivalents: Skin Lipid Assessment and Morphological Evaluation“. Journal of Veterinary Medicine 2013 (06.11.2013): 1–9. http://dx.doi.org/10.1155/2013/231526.

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A canine skin equivalent model has been validated for the assessment of a topical formulation effects. Skin equivalents were developed from freshly isolated cutaneous canine fibroblasts and keratinocytes, after enzymatic digestion of skin samples (n=8) from different breeds. Fibroblasts were embedded into a collagen type I matrix, and keratinocytes were seeded onto its surface at air-liquid interface. Skin equivalents were supplemented with essential oils and polyunsaturated fatty acid formulation or with vehicle. Skin equivalents were histopathologically and ultrastructurally studied, and the three main lipid groups (free fatty acids, cholesterol, and ceramides) were analyzed. Results showed that the culture method developed resulted in significant improvements in cell retrieval and confluence. Treated samples presented a thicker epidermis with increased number of viable cell layers, a denser and compact stratum corneum, and a more continuous basal membrane. Regarding lipid profile, treated skin equivalents showed a significant increase in ceramide content (51.7±1.3) when compared to untreated (41.6 ± 1.4) samples. Ultrastructural study evidenced a compact and well-organized stratum corneum in both treated and control skin equivalents. In conclusion, cell viability and ceramides increase, after lipid supplementation, are especially relevant for the treatment of skin barrier disruptions occurring in canine atopic dermatitis.

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Ryu, Y. H., K. M. Jung, S. H. Lee, K. M. Lim und B. H. Kim. „Optimized in vitro skin irritation test using reconstructed human skin equivalent model, Keraskin(“. Toxicology Letters 196 (Juli 2010): S140. http://dx.doi.org/10.1016/j.toxlet.2010.03.487.

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29

Loke, Amanda S. W., B. Jack Longley, Paul F. Lambert und Megan E. Spurgeon. „A Novel In Vitro Culture Model System to Study Merkel Cell Polyomavirus–Associated MCC Using Three-Dimensional Organotypic Raft Equivalents of Human Skin“. Viruses 13, Nr. 1 (19.01.2021): 138. http://dx.doi.org/10.3390/v13010138.

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Merkel cell polyomavirus (MCPyV) is a human polyomavirus causally linked to the development of Merkel cell carcinoma (MCC), an aggressive malignancy that largely arises within the dermis of the skin. In this study, we recapitulate the histopathology of human MCC tumors in vitro using an organotypic (raft) culture system that is traditionally used to recapitulate the dermal and epidermal equivalents of skin in three dimensions (3D). In the optimal culture condition, MCPyV+ MCC cells were embedded in collagen between the epidermal equivalent comprising human keratinocytes and a dermal equivalent containing fibroblasts, resulting in MCC-like lesions arising within the dermal equivalent. The presence and organization of MCC cells within these dermal lesions were characterized through biomarker analyses. Interestingly, co-culture of MCPyV+ MCC together with keratinocytes specifically within the epidermal equivalent of the raft did not reproduce human MCC morphology, nor were any keratinocytes necessary for MCC-like lesions to develop in the dermal equivalent. This 3D tissue culture system provides a novel in vitro platform for studying the role of MCPyV T antigens in MCC oncogenesis, identifying additional factors involved in this process, and for screening potential MCPyV+ MCC therapeutic strategies.

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Liu, Youhua, und Rakesh K. Kapania. „Equivalent Skin Analysis of Wing Structures Using Neural Networks“. AIAA Journal 39, Nr. 7 (Juli 2001): 1390–99. http://dx.doi.org/10.2514/2.1459.

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31

Nelson, D., und R. J. Gay. „EFFECTS OF UV IRRADIATION ON A LIVING SKIN EQUIVALENT“. Photochemistry and Photobiology 57, Nr. 5 (Mai 1993): 830–37. http://dx.doi.org/10.1111/j.1751-1097.1993.tb09219.x.

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32

O'keefe, Edward J., David T. Woodley, Ronald J. Falk, W. Ray Gammon und Robert A. Briggaman. „Production of Fibronectin by Epithelium in a Skin Equivalent“. Journal of Investigative Dermatology 88, Nr. 5 (Mai 1987): 634–39. http://dx.doi.org/10.1111/1523-1747.ep12470246.

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Lacik, Jaroslav, Vladimir Hebelka, Jan Velim, Zbynek Raida und Jan Puskely. „Wideband Skin-Equivalent Phantom for V- and W-Band“. IEEE Antennas and Wireless Propagation Letters 15 (2016): 211–13. http://dx.doi.org/10.1109/lawp.2015.2438441.

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Cerrato, Santiago, Laura Ramió-Lluch, Pilar Brazís, Rosa Maria Rabanal, Dolors Fondevila und Anna Puigdemont. „Development and characterization of an equine skin-equivalent model“. Veterinary Dermatology 25, Nr. 5 (18.07.2014): 475—e77. http://dx.doi.org/10.1111/vde.12134.

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Mori, Nobuhito, Yuya Morimoto und Shoji Takeuchi. „Perfusable and stretchable 3D culture system for skin-equivalent“. Biofabrication 11, Nr. 1 (15.11.2018): 011001. http://dx.doi.org/10.1088/1758-5090/aaed12.

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36

Yang, Lujun, Yuji Shirakata, Masachika Shudou, Xiuju Dai, Sho Tokumaru, Satoshi Hirakawa, Koji Sayama, Junji Hamuro und Koji Hashimoto. „New skin-equivalent model from de-epithelialized amnion membrane“. Cell and Tissue Research 326, Nr. 1 (07.06.2006): 69–77. http://dx.doi.org/10.1007/s00441-006-0208-2.

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37

Black, Annie F., Charbel Bouez, Eric Perrier, Kordula Schlotmann, François Chapuis und Odile Damour. „Optimization and Characterization of an Engineered Human Skin Equivalent“. Tissue Engineering 11, Nr. 5-6 (Mai 2005): 723–33. http://dx.doi.org/10.1089/ten.2005.11.723.

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38

MacLeod, T. M., A. Cambrey, G. Williams, R. Sanders und C. J. Green. „Evaluation of Permacol™ as a cultured skin equivalent“. Burns 34, Nr. 8 (Dezember 2008): 1169–75. http://dx.doi.org/10.1016/j.burns.2008.01.013.

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39

Liu, Youhua, und Rakesh K. Kapania. „Equivalent skin analysis of wing structures using neural networks“. AIAA Journal 39 (Januar 2001): 1390–99. http://dx.doi.org/10.2514/3.14879.

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40

Dubertret, L. „Reconstruction of the Human Skin Equivalent in vitro: A New Tool for Skin Biology“. Skin Pharmacology and Physiology 3, Nr. 2 (1990): 144–48. http://dx.doi.org/10.1159/000210861.

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41

&NA;. „SUCCESSFUL TRANSPLANTATION OF TISSUE-ENGINEERED SKIN EQUIVALENT BASED ON AUTOLOGOUS TRANSFORMATION OF ALLOGRAFT SKIN.“ Transplantation 82, Suppl 2 (Juli 2006): 746. http://dx.doi.org/10.1097/00007890-200607152-02042.

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42

Petrali, J. P., S. B. Oglesby und T. A. Justus. „Morphological effects of sulfur mustard on a human skin equivalent“. Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 78–79. http://dx.doi.org/10.1017/s0424820100084697.

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We have previously reported morphological correlates of sulfur mustard (HD) toxicity in several model systems: the human skin grafted athymic nude mouse; the hairless guinea pig; and human cells in culture. We are now describing HD effects in a human skin equivalent, TESTSKIN®, and comparing these effects with those already reported for animal models and cells in culture. The human skin equivalent (HSE) is used here as an organotypic in vitro model system to bridge the knowledge gap between HD effects in monotypic cells in culture and animal in vivo effects. Additionally, HSE allowed study of HD toxicity which circumvented the concern of using human biopsied tissue.

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Kim, Kyunghee, Hyeju Kim und Gun Yong Sung. „An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip“. International Journal of Molecular Sciences 23, Nr. 4 (14.02.2022): 2116. http://dx.doi.org/10.3390/ijms23042116.

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Currently, the mechanism of progression of atopic dermatitis (AD) is not well understood because there is no physiologically appropriate disease model in terms of disease complexity and multifactoriality. Type 2 inflammation, mediated by interleukin (IL)-4 and IL-13, plays an important role in AD. In this study, full-thickness human skin equivalents consisting of human-derived cells were fabricated from pumpless microfluidic chips and stimulated with IL-4 and IL-13. The morphological properties, gene expression, cytokine secretion and protein expression of the stimulated human skin equivalent (HSE) epidermis were investigated. The results showed epidermal and spongy formations similar to those observed in lesions in AD, and decreased expression of barrier-related filaggrin, loricrin and involucrin genes and proteins induced by IL-4Rα signaling. In addition, we induced the expression of carbonic anhydrase II (CAII), a gene specifically expressed in the epidermis of patients with AD. Thus, AD human skin equivalents can be used to mimic the key pathological features of atopic dermatitis, overcoming the limitations of existing studies that rely solely on mouse models and have been unable to translate their effects to humans. Our results will be useful for future research on the development of therapeutic agents for atopic dermatitis.

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Kim, Jisue, Kyunghee Kim und Gun Yong Sung. „Coenzyme Q10 Efficacy Test for Human Skin Equivalents Using a Pumpless Skin-On-A-Chip System“. International Journal of Molecular Sciences 21, Nr. 22 (11.11.2020): 8475. http://dx.doi.org/10.3390/ijms21228475.

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A human skin equivalent (HSE) composed of the epidermis and dermis is cultured using a pumpless skin-on-a-chip system to supply cultures the desired flow rate using gravity flow without a pump or an external tube connection. Coenzyme Q10 efficacy is tested by adjusting its concentration, as it is known to have anti-aging and antioxidant effects in culture solutions. The relationship between the contraction rate of a full-thickness human skin equivalent and secreted transforming growth factor (TGF) β-1 is analyzed via enzyme-linked immunosorbent assay (ELISA). Following hematoxylin and eosin (H&E) staining, an image of the skin equivalent is analyzed to measure the epidermal layer’s thickness. The cell density and differentiation of the dermis layer are investigated. Gene and protein expression in the dermal and epidermal layers are quantitatively analyzed using quantitative real time polymerase chain reaction (qPCR) and immunohistochemical staining. As the coenzyme Q10 treatment concentration increased, the number of cells per unit area and the thickness of the epidermal layer increased, the expression level of filaggrin increased, and the contraction rate of full-thickness HSE was proportional to the amount of TGF β-1 secreted.

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Trasia, Reqgi First. „Utilization of Human Skin Equivalent in Research of Scabies Pathogenesis“. NUCLEUS 1, Nr. 1 (15.05.2020): 1–7. http://dx.doi.org/10.37010/nuc.v1i1.63.

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Scabies is a tropical disease that requires large-scale control. Research on the pathogenesis of scabies in Indonesia is still rare. Meanwhile, in tropical countries, studies related to the course of scabies have been done quite a lot, one of which is by using a human skin model. The purpose of writing this article is to discuss the use of human skin modeling technology in researching the course of scabies. Research using HSE demonstrated modulation of cytokine secretion, expression of cell adhesion molecules, and gene expression in response to the scabies mite extract molecule.

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Trasia, Reqgi First. „Utilization of Human Skin Equivalent in Research of Scabies Pathogenesis“. NUCLEUS 1, Nr. 1 (15.05.2020): 1–7. http://dx.doi.org/10.37010/nuc.v1i1.63.

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Scabies is a tropical disease that requires large-scale control. Research on the pathogenesis of scabies in Indonesia is still rare. Meanwhile, in tropical countries, studies related to the course of scabies have been done quite a lot, one of which is by using a human skin model. The purpose of writing this article is to discuss the use of human skin modeling technology in researching the course of scabies. Research using HSE demonstrated modulation of cytokine secretion, expression of cell adhesion molecules, and gene expression in response to the scabies mite extract molecule.

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&NA;. „Treatment with daptomycin is equivalent to conventional therapy for complicated skin and skin structure infections“,. Inpharma Weekly &NA;, Nr. 1450 (August 2004): 12. http://dx.doi.org/10.2165/00128413-200414500-00026.

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Bjellerup, Mats. „Novel Method for Training Skin Flap Surgery: Polyurethane Foam Dressing Used as a Skin Equivalent“. Dermatologic Surgery 31, Nr. 9 (21.03.2006): 1107–11. http://dx.doi.org/10.1111/j.1524-4725.2005.31904.

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OBI-TABOT, ELIOT T., XIAO QUAN TIAN, TAI C. CHEN und MICHAEL F. HOLICK. „A HUMAN SKIN EQUIVALENT MODEL THAT MIMICS THE PHOTOPRODUCTION OF VITAMIN D3 IN HUMAN SKIN“. In Vitro Cellular & Developmental Biology - Animal 36, Nr. 3 (2000): 201. http://dx.doi.org/10.1290/1071-2690(2000)036<0201:ahsemt>2.0.co;2.

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OBI-TABOT, ELIOT T., XIAO QUAN TIAN, TAI C. CHEN und MICHAEL F. HOLICK. „A HUMAN SKIN EQUIVALENT MODEL THAT MIMICS THE PHOTOPRODUCTION OF VITAMIN D3 IN HUMAN SKIN“. In Vitro Cellular and Developmental Biology--Animal 36, Nr. 3 (März 2000): 201–4. http://dx.doi.org/10.1290/1071-2690(2000)036<0201:ahsemt>2.3.co;2.

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