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Ramasari, Risti Dwi, Intan Nurina und Reza Uyundoya. „GUGATAN WANPRESTASI TERHADAP TUNGGAKAN PEMBAYARAN BARANG FARMASI KEPADA PERUSAHAAB DISTRIBUTOR FARMASI (Studi Putusan Nomor 15/Pdt.Gs/2022/PN.Tjk)“. JURNAL RECTUM: Tinjauan Yuridis Penanganan Tindak Pidana 5, Nr. 1 (28.02.2023): 1164. http://dx.doi.org/10.46930/jurnalrectum.v5i1.2936.
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Default comes from the Dutch language "wanprestastie", which means non-fulfillment of achievements or obligations that have been assigned to certain parties in an engagement, both agreements born of an agreement or agreements arising from a law. According to the Legal Dictionary, default means negligence, negligence, default, not fulfilling its obligations in the agreement. Legal Consequences of Default Against Arrears in Payment of Pharmaceutical Goods to Pharmaceutical Distributor Companies in Decision Number 15/Pdt.Gs/2022/ PN. Tjk is that Muhamad Sutedjo must pay his payment obligations to the Plaintiff Rp. 113,424,307.50 (one hundred thirteen million four hundred twenty four thousand three hundred seven rupiah and fifty cents). And plus paying interest of 6% (six percent) per year from IDR 113,424,307.50 (one hundred thirteen million four hundred twenty four thousand three hundred seven rupiah fifty cents) starting from June 14, 2022 (due date of subpoena second from the Plaintiff) until this decision was read out and the Basis for consideration of the Judge in imposing a decision on default in the arrears of payment for pharmaceutical goods to a Pharmaceutical Distributor Company in Decision Number 15/Pdt.Gs/2022/PN.Tjk is based on the provisions in Article 1320 KUH Civil requirements for the validity of an agreement, Article 1925 of the Civil Code Jo Article 163 HIR/283 RBg because the Defendant did not dispute, Supreme Court Jurisprudence Number 063 K/PDT/1987 concerning Addition of interest of 6% of the principal amount of the loan and Article 18 paragraph (1) Perma Number 4 of 2019 concerning Amendments to Perma Number 2 of 2015 concerning Procedures for Settlement of Simple Claims.
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Aggerholm, K., und P. Illum. „Surgical treatment of Zenker's diverticulum“. Journal of Laryngology & Otology 104, Nr. 4 (April 1990): 312–14. http://dx.doi.org/10.1017/s0022215100112575.
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AbstractOne-hundred-and-fifty patients with Zenker's diverticulum were reviewed; twelve patients received no treatment; 26 patients were treated endoscopically by dilatation, five of these had a diverticulectomy performed at a later stage.One-hundred-and-ten patients had a diverticulectomy performed (a total of 115 primary operations were performed). Eighteen of the patients operated upon had a recurrence and six underwent re-operation.Local complications occurred in 24 patients. Seven patients had a fistula and two had mediastinitis. Ten patients had recurrent nerve palsy, of which five were permanent. Thirteen patients had other complications, usually infection. One death occurred.Post-operative prophylactic treatment with antibiotics was found to significantly reduce the number of local infectious complications and a correlation was found between the occurrence of local, infectious complications and later recurrence of the pouch.
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O.C. Aniekwu, Bernard. „THE ROLE OF HEALTH OUTCOMES ON C, ALBICANS, AND T, VAGINALISPREVALENCE AMONG PREGNANT WOMEN IN SOUTH-EAST NIGERIA“. International Journal of Advanced Research 9, Nr. 4 (30.04.2021): 553–57. http://dx.doi.org/10.21474/ijar01/12730.
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The purpose of the current study was to investigate the role of diabetes, hypertension, prolonged use of antibiotics and use of contraceptives on pregnant women with C. albicans and T. vaginalis infections. Three hundred and thirty-six vaginal specimens were collected from pregnant women through their consulting physicians in the selected health institutions within the study parameter. The test result revealed that only one hundred and thirteen of the total vaginal specimens tested positive for C. albicans, while seventeen tested positive for T. vaginalis. However, data from the questionnaire relating to health outcomes revealed that mostly the reported health positions were from the participants diagnosed with candidiasis. Only a few with trichomoniasis reported any of the health outcomes. The study concluded that the health conditions studied were correlated with the prevalence of infections among pregnant women in Nigerias South-East.
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Laituri, Carrie, Andre Teixeira, Matthew W. Lube, Aaron Seims und Jeremy Cravens. „Trauma Laparotomy: Evaluating the Necessity of Histological Examination“. American Surgeon 75, Nr. 11 (November 2009): 1124–27. http://dx.doi.org/10.1177/000313480907501120.
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Trauma laparotomy is the most commonly performed procedure in the acute care setting. As current practice, removed specimens are sent for histological examination. A retrospective review of all trauma laparotomies with specimens removed and sent to pathology during a 12-month period was performed in a Level I trauma center. One hundred five procedures of 244 trauma laparotomies yielded specimens sent for examination. Eighty-six patients were male and 19 patients were female with an average age of 34 ± 14 years. Fifty-six per cent of the injuries resulted from penetrating trauma and 44 per cent were from blunt trauma. Gunshot wound and motor vehicle crash were the most common penetrating and blunt injuries, respectively. One hundred thirteen specimens were sent to pathology. Forty-three per cent of the specimens were spleen, 24 per cent small bowel, 16 per cent large bowel, 4 per cent kidney, 2 per cent omentum, 3 per cent appendix, 3 per cent pancreas, and 1 per cent for gallbladder and lung. One hundred twelve of 113 grossly normal specimens had normal pathology. One grossly normal specimen exposed abnormal pathology revealing benign appendiceal mucocele. Therefore, 99.1 per cent of grossly normal specimens sent for histological examination after trauma laparotomy were normal. Based on our review, in select patients routine histological examination of tissues removed for traumatic injury is unnecessary.
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Hu, Cao Yuan, Hai Yan Li, Xiao Ming Huang und Zhi Li. „Analysis of Density of PM2.5 under Diffusion and Attenuation Based on Non-Stationary Two-Dimensional Multi-Box Model“. Advanced Materials Research 955-959 (Juni 2014): 2505–12. http://dx.doi.org/10.4028/www.scientific.net/amr.955-959.2505.
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High density of PM2.5 that has an insignificant contribution to the increasing dusty weather threats the physicaland mental health of approximate six hundred millions Chinese recently. In this paper, we investigate thediffusion and attenuation of PM2.5 and give a prediction of its density in Xi’an city, which is based on nonstationarytwo-dimensional multi-box model, while considering the effect of seasons and wind direction. Asimulation is conducted with data from thirteen random selected stations. Furthermore, by comparing the realmeasured value and numeric value, we evaluate the validity of our proposed model as well as giving the relativeerror.Keywords: Two-Dimensional Multi-Box model, PM2.5, Diffusion, Attenuation.
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Mateen, Abdul, Famya Abdullah, Muhammad Saeed Akhtar, Arif Moin Quraishi, Amir Sattar, Quratul Ain Hashmi, Isharat Shehrood Sanwal, Faryal Jamil, Rida Safdar und Allah Rakha Adil. „Efficacy of low dose sorafenib and capecitabine in the management of hepatocellular cancer.“ Journal of Clinical Oncology 41, Nr. 16_suppl (01.06.2023): e16117-e16117. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16117.
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e16117 Background: Hepatocellular cancer (HCC) is one of the commonest cancers in Pakistan due to endemic hepatitis B and C diseases. Its incidence is continuously rising due to lack of public awareness and lack of routine screening of the affected population. Most of the patients present in advanced stage of the disease excluding option for curative surgical options. These patients are mostly not fit enough to tolerate systemic therapies in full doses. So, we have to adapt ourselves to lower dosage so that it can be tolerated without many untoward side effects. Methods: This study was aimed to assess the efficacy of low dose sorafenib (400 mg daily in two divided doses) and capecitabine (1000 mg daily in two divided doses) in advanced hepatocellular carcinoma. Patients were prescribed this treatment for six months and then response was assessed using computed tomography or ultrasound and alpha fetoprotein (AFP) levels. Progression-free survival (PFS) and overall survival (OS) were also assessed. Results: Total of one-hundred fifty-five patients were enrolled. One hundred thirteen patients completed the treatment for six months and were evaluated for response. A total of 28 (25%) of patients progressed during treatment and were shifted to other treatment options. Nine patients (8%) had complete response, thirty-four (30%) had partial response, forty-two (37%) had stable disease and twenty-eight (25%) had progressive disease. Seventy-four patients (65%) showed significant reduction in AFP levels. A total of 85/113 (75%) patients were available for assessment of PFS and OS. Two-year PFS and OS were 32% and 43% respectively. Mean and median PFS (year) were 1.82 ±0.19 (95% confidence interval 1.48 to 2.17) and 1.27±0.16 (95% confidence interval 0.94 to 1.57) respectively. Mean and median OS (year) were 2.73 ±0.24 (95% confidence interval 2.39 to 3.16) and 2.27±0.13 (confidence interval 2.02 to 2.54) respectively. Twenty-six patients had one or more episode of grade 2 diarrhea, eleven patients developed encephalopathy, thirteen patients developed hand foot syndrome and nineteen patients showed grade 2 thrombocytopenia. Conclusions: Low dose sorafenib and capecitabine is effective in the treatment of advanced HCC with excellent tolerability and minimal toxicity.
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Kiiru, Harrison Wachira, Githae Wanyona, Stephen Diang’a und John Kihoro. „The Influence of Contractors’ Selection Attributes. A Study of Public Construction Projects Performance in Kenya“. East African Journal of Business and Economics 7, Nr. 1 (03.07.2024): 295–312. http://dx.doi.org/10.37284/eajbe.7.1.2017.
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This paper evaluated the influence of contractors’ selection attributes on public construction project performance in Kenya. This research contends that an investigation into contractors’ selection attributes at the tender evaluation stage is important to enhance the likelihood of public construction project success performance. The study used a survey method and administered questionnaires to 263 respondents selected through stratified sampling. One hundred and eighty-nine (189) practitioners and professionals in state agencies returned filed questionnaires representing a 71.86% return rate. The literature review and interview reveal thirteen contractor selection variables and six project performance criteria. SPSS was used to analyse the data set obtained for reliability, normality, correlation, and logit regression test. Logit regression analysis reveals the omnibus test of model coefficients converged (Chi-square=26.116, df=13, p=0.016). The model summary reveals Nagelkerke R^2 of 0.246 indicating a relationship of 24.6% between the thirteen predictor variables and project performance indicators. It was found that contractors quoted tender price (Exp (B) = 1.866), innovation (Exp (B) = 2.808), and occupation health and safety (Exp (B) = 0.358) significantly influence the performance of public construction projects when all other contractor's selection variables are controlled. This indicates that the contractor’s quoted tender price, innovation, and occupation health and safety explain well the success of the public construction project from thea six (performance by budget, time, procuring entity satisfaction, environmental sustainability, quality specifications, and fulfilling public need) project performance indicators
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Asensio-Ramon, Jorge, Joaquín F. Álvarez-Hernández, José M. Aguilar-Parra, Rubén Trigueros, Ana Manzano-León, Juan M. Fernandez-Campoy und Carolina Fernández-Jiménez. „The Influence of the Scout Movement as a Free Time Option on Improving Academic Performance, Self-Esteem and Social Skills in Adolescents“. International Journal of Environmental Research and Public Health 17, Nr. 14 (19.07.2020): 5215. http://dx.doi.org/10.3390/ijerph17145215.
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The word scouting refers to the Scout movement, born more than a hundred years ago, which educates millions of young people between the ages of six and twenty-one in their leisure time. We aimed to study the effects of scouting on the academic results, social skills, and self-esteem of high school youths compared to a non-scout sample. The selected sample consisted of 430 secondary students aged between thirteen and seventeen. Self-esteem and social skills were measured, and the average mark of the total sample was analysed. After the study, it was shown that belonging to the scout movement significantly influences the improvement of academic results in formal education and conflict resolution; however, there are no statistically significant differences in self-esteem and other social skills.
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Auta, Filibus Jamaka. „Re-Engineering Education and Development from the Prevalence of System Architecture of the Social Media Network“. International Letters of Social and Humanistic Sciences 32 (Juni 2014): 1–13. http://dx.doi.org/10.18052/www.scipress.com/ilshs.32.1.
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This paper examines how four systems of re-engineering principles namely, complete operational process system, set-transformation system socio-technical system and technical/workflow environmental analysis re-engineering system, these systems have contributed to life-changing opportunities created by mobile and web-based digital telecommunication systems, the social media networks. The paper also highlighted the structure, functions, and transformation of the society resulting from cell phone design, social media simulation and modelling. They have not only contributed immensely in education and development, especially among the youth. Despite, the regulation policy of government, network providers, a whooping one hundred and sixty-four thousand, six hundred and forty-two subscribers in the year two thousand and thirteen, the number is still growing, are online for education and development. Subscribers are sometimes found on the contradictory side of social practice when they are suppose to confine to practice of environmental learning, distance learning, long-life learning, formal and informal education to avoid danger, restrictions contradictions, that had been the vision mission of the preceding mass media practice which has now exploded to a digital telecommunication broadband of the cell phones/satellite phones, popularly named the social media networks.
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Cmelak, Anthony J., Sigui Li, Meredith A. Goldwasser, Barbara Murphy, Michael Cannon, Harlan Pinto, David I. Rosenthal, Maura Gillison und Arlene A. Forastiere. „Phase II Trial of Chemoradiation for Organ Preservation in Resectable Stage III or IV Squamous Cell Carcinomas of the Larynx or Oropharynx: Results of Eastern Cooperative Oncology Group Study E2399“. Journal of Clinical Oncology 25, Nr. 25 (01.09.2007): 3971–77. http://dx.doi.org/10.1200/jco.2007.10.8951.
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PurposeTaxane-based concurrent chemoradiotherapy (CCR) for head and neck cancers has proven to have a favorable toxicity profile compared with cisplatin and radiation. This phase II multi-institutional trial evaluates taxane-based induction chemotherapy followed by CCR for organ preservation in resectable stage III/IVA and IVB larynx and oropharynx (OP) cancer patients.Patients and MethodsEligibility required resectable stage T2N+, or T3-T4N0-3M0 biopsy-proven squamous carcinoma, age at least 18 years, PS 0 to 2, good organ function, and no prior chemotherapy or radiation. Treatment was induction paclitaxel 175 mg/m2and carboplatin area under the concentration-time curve (AUC) 6 for two cycles every 21 days followed by concurrent paclitaxel 30 mg/m2every 7 days with 70 Gy if no evidence of tumor progression. Weekly erythropoietin alpha 40 kU was used for suboptimal hemoglobin (< 14 gm/dL men, < 13 gm/dL women). The primary end point was organ preservation (freedom from primary site salvage surgery or primary tumor recurrence).ResultsOne hundred five of 111 patients (36 larynx, 69 OP) were eligible. Median follow-up was 36.7 months. Ninety-four percent received full-dose radiotherapy and 91% received at least five cycles of concurrent paclitaxel. No patient progressed while receiving chemotherapy. Organ preservation was 81% at 2 years after completion of therapy (larynx 74%, OP 84%). Thirteen patients required primary-site salvage surgery (seven larynx, six OP), and six of these have progressed and died (three larynx, three OP). Thirteen patients developed distant metastases (seven larynx, six OP; P = .02) and 10 of 36 larynx and 11 of 69 OP patients have died as a result of their disease. Two-year survival is 76% (63% larynx v 83% OP).ConclusionA high organ preservation rate was obtained with this regimen for OP but not for larynx patients. Toxicity was low, and induction chemotherapy did not preclude delivery of concurrent chemoradiotherapy.
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Sweetow, Robert, und Catherine V. Palmer. „Efficacy of Individual Auditory Training in Adults: A Systematic Review of the Evidence“. Journal of the American Academy of Audiology 16, Nr. 07 (Juli 2005): 494–504. http://dx.doi.org/10.3766/jaaa.16.7.9.
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A systematic review of the literature was conducted addressing the following question, "Is there evidence of improvement in communication skills through individual auditory training in an adult hearing-impaired population?" Keywords and authors were used as search terms in eight major indexes, and seven textbooks were reviewed for related references. The level of evidence that was accepted included randomized controlled trials, nonrandomized controlled trials, cohort, and before/after designs with or without control groups. Two hundred thirteen articles were identified during the preliminary search with 171 of these eliminated by review of abstracts because they did not meet the search criteria. Forty-two manuscripts were reviewed, with six meeting the evidence and search criteria. The strengths and weaknesses of these studies are highlighted, and the systematic review question is answered in light of these studies. In addition, elements critical to the future of auditory training research and clinical practice are offered.
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Opirite Boma, PETER-KIO, und ORDU Caroline Nne. „Perception and Determinants of Caregivers Participation in Immunization in Rivers East Senatorial District, Nigeria“. INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT 6, Nr. 1 (02.07.2022): 1–12. http://dx.doi.org/10.56201/ijmepr.v6.no1.2022.pg1.12.
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This study investigated the perception and determinants of caregivers’ participation in immunization in Rivers East Senatorial District, Nigeria. The study adopted the descriptive research design with a population which consisted of three million, nine hundred and thirteen thousand, six hundred and eighty-three (3,913,683) persons in Rivers East Senatorial District. A sample size of 512 was selected using the multistage sampling procedure. Data was collected using a structured questionnaire with a reliability coefficient of 0.75 while analysis was carried out using percentage and chi-square. The result showed that, majority 488(97.6%) of the respondents had positive perception, high level of participation (99.4%). However, no statistically significant relationship was found between participation and other factors such as perception (X2-value = 0.61, df = 1, p>0.05), religion (X2-value = 0.66, df = 2, p>0.05), and age (X2-value = 3.58, df = 4, p>0.05). It was concluded that caregivers in Rivers East senatorial district had positive perception towards immunization and a high level of participation in immunization. It was recommended that, public health practitioners should embark on community based interventions through proper counseling to clear every negative perception about childhood immunization arising from lack of information which influences its participation
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Shumate, Alice M., Jamille Taylor, Elizabeth McFarland, Christina Tan und Mary Anne Duncan. „Medical Response to a Vinyl Chloride Release From a Train Derailment: New Jersey, 2012“. Disaster Medicine and Public Health Preparedness 11, Nr. 5 (06.03.2017): 538–44. http://dx.doi.org/10.1017/dmp.2016.191.
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AbstractObjectiveThe objective of this investigation was to examine the health impact of and medical response to a mass casualty chemical incident caused by a vinyl chloride release.MethodsKey staff at area hospitals were interviewed about communication during the response, the number of patients treated and care required, and lessons learned. Clinical information related to the incident and medical history were abstracted from hospital charts.ResultsHospital interviews identified a desire for more thorough and timely incident-specific information and an under-utilization of regionally available resources. Two hundred fifty-six hospital visits (96.2%) were at the facility closest to the site of the derailment. Of 237 initial visits at which the patient was examined by a physician, 231 patients (97.5%) were treated in the emergency department (ED) and 6 patients (2.5%) were admitted; 5 admitted patients (83.3%) had preexisting medical conditions. Thirteen of 14 asymptomatic ED patients were children under the age of 10 years. One hundred forty-five patients (62.8%) discharged from the ED were diagnosed solely with exposure to vinyl chloride.ConclusionsContinuous emergency response planning might facilitate communication and better distribution of patient surge across hospitals. Individuals with multiple medical conditions and parents and caretakers of children may serve as target groups for risk communication following acute chemical releases. (Disaster Med Public Health Preparedness. 2017;11:538–544)
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Puspitasari, Azzahra Salsabila, und Alikha Novira. „Evaluation of Deconcentration Funds in the Regional Development Planning Agency (Bappeda) Central Java Province“. Assets : Jurnal Ilmiah Ilmu Akuntansi, Keuangan dan Pajak 6, Nr. 2 (31.07.2022): 108–18. http://dx.doi.org/10.30741/assets.v6i2.879.
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Deconcentration funds are one form of the central government to hold an equitable government in each region using the State Revenue and Expenditure Budget (APBN). The implementation of this deconcentration fund is directly supervised by the governor as a representative of the central government which is included in vertical agencies. The research method used in this journal is the CSE-UCLA evaluation model with research approach used using a qualitative approach with documentation, interviews, and observation methods. Most of the data taken are from the results of documentation studies with data analysis techniques, namely data reduction, data presentation, and conclusion. In the use of deconcentration funds in the Central Java Province for the budget year 2021, which is Rp. 1,144,613,000, - (one billion one hundred forty-four million six hundred thirteen thousand rupiah) which among others is used for expenditure on operational goods, expenditure on non-operational goods, expenditure on supplies, service expenditure, and expenditure on domestic business trips. In its implementation, two obstacles occur. The first obstacle is the change in administrative requirements for disbursing deconcentration funds. The second obstacle occurred because of the COVID-19 pandemic, so there were several activities whose implementation was delayed until the situation could be said to be safe to carry out activities.
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Nohwar, Amit Kumar, Vaishali P. Venu und Ravikant Singh. „Role of integrated therapy and nutritional counselling in treating malnourished children in M-East ward Mumbai, India: A Longitudinal Study“. Indian Journal of Community Health 33, Nr. 4 (31.12.2021): 592–96. http://dx.doi.org/10.47203/ijch.2021.v33i04.009.
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Background: Under-nutrition is a big risk factor for increasing the morbidity and mortality burden in the society. Acute malnutrition contributes to almost 61% of diarrheal and 53% of pneumonia deaths. In urban slums like M-East ward, Mumbai, acute malnutrition prevalence ranges from 16% to 59.8%. Objectives: To assess the outcome of weight gain by providing nutritional supplements to the undernourished children along with nutritional counseling. Materials and Methods: RUTF (Ready-to-Use Therapeutic Food) and Hyderabad mix with nutritional counselling to parents of children were used to reduce the undernourishment among the under-five children in slums of this ward. Six hundred and fifty malnourished children and their caregivers were provided nutritional supplement and nutritional counselling over 6 months. Results: There was steady wight gain of enrolled children. Highest weight gain occurred over 13th week of the program. Conclusion: A minimum of thirteen weeks nutritional supplement program including fortnightly counselling is necessary and sufficient for converting undernourished children to normal.1
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Viana, André L. M., Rodrigo Cayô, Cassia C. Avelino, Ana C. Gales, Marília C. Franco und Luciene A. R. Minarini. „Extended-spectrum β-lactamases in Enterobacteriaceae isolated in Brazil carry distinct types of plasmid-mediated quinolone resistance genes“. Journal of Medical Microbiology 62, Nr. 9 (01.09.2013): 1326–31. http://dx.doi.org/10.1099/jmm.0.055970-0.
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One hundred and six nalidixic acid-resistant Enterobacteriaceae isolates from two Brazilian hospitals isolated from June to October 2010 were evaluated to characterize the co-existence of plasmid-mediated quinolone resistant (PMQR) and extended-spectrum β-lactamase (ESBL) determinants. The qnr genetic environment was determined by PCR and sequencing. Conjugation and hybridization experiments determined whether qnr-carrying plasmids were self-transferable. The aac(6′)-Ib-cr and qepA genes were also screened. Thirteen qnr-like genes (12.3 %) were identified, with qnrB1 the most common, followed by qnrS1, qnrB2 and qnrB19. No qnrA, qnrC, qnrD or qepA determinant was detected. All qnr-positive strains possessed chromosomal substitutions in gyrase- and topoisomerase-encoding genes and four harboured a aac(6′)-Ib-cr gene. The co-production of bla CTX-M was observed in ten qnr-positive strains. These results indicate the dissemination of PMQR genes shown in clinical isolates from Brazil, and their co-existence with ESBL genes emphasizes the complexity of plasmid-mediated resistance determinants among Enterobacteriaceae.
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Rakhman, Muhammad Baitur, und Ahmad Suwandi. „Perencanaan Tebal Perkerasan Jalan Sergang – Jembatan Jengkong (No. 243) KM 8 Batu Putih Kabupaten Sumenep“. Ge-STRAM: Jurnal Perencanaan dan Rekayasa Sipil 2, Nr. 2 (30.09.2019): 89. http://dx.doi.org/10.25139/jprs.v2i2.1963.
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The white stone mine in Batu Putih Village is one of the natural resources located in Sumenep Regency, precisely on Sergang Street - Jengkong Bridge No. 243 Km 8. This road is the only access road to the white stone mining. The current condition of the road is damaged and interferes with the distribution process of white stones, so good thick pavement planning is needed. Planning of flexible pavement thickness and the cost of flexible pavement construction on Sergang - Jengkong Bridge No. 243 Km 8 Batu Putih, Sumenep Regency uses quantitative research. The data collection process uses two types of data, the first is primary data which includes LHR data and the second is secondary data which includes literature and literature studies. In this research the data analysis technique uses Microsoft Office Excel which is to calculate the budget plan and Autocad for drawing. For calculation procedures adjusted to SNI -1732-1989. The results of the Average Daily Traffic Survey (LHR) obtained the total number of vehicles passing through by 21164 smp. The road to be planned is 3 Km long and 4 m wide. Calculation of pavement thickness using the laston AC-WC is 2.50 cm thick and will be planned to be 4 cm thick. The planned budget (RAB) for the road planning is Rp. 2,613,171,000.00 (two billion six hundred thirteen million one hundred seventy-one thousand rupiah).
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Arrey, Eliel N., Marcia L. Kerr, Stephen Fletcher, Charles S. Cox und David I. Sandberg. „Linear nondisplaced skull fractures in children: who should be observed or admitted?“ Journal of Neurosurgery: Pediatrics 16, Nr. 6 (Dezember 2015): 703–8. http://dx.doi.org/10.3171/2015.4.peds1545.
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OBJECT In this study the authors reviewed clinical management and outcomes in a large series of children with isolated linear nondisplaced skull fractures (NDSFs). Factors associated with hospitalization of these patients and costs of management were also reviewed. METHODS After institutional review board approval, the authors retrospectively reviewed clinical records and imaging studies for patients between the ages of 0 and 16 years who were evaluated for NDSFs at a single children’s hospital between January 2009 and December 2013. Patients were excluded if the fracture was open or comminuted. Additional exclusion criteria included intracranial hemorrhage, more than 1 skull fracture, or pneumocephalus. RESULTS Three hundred twenty-six patients met inclusion criteria. The median patient age was 19 months (range 2 weeks to 15 years). One hundred ninety-three patients (59%) were male and 133 (41%) were female. One hundred eighty-four patients (56%) were placed under 23-hour observation, 87 (27%) were admitted to the hospital, and 55 patients (17%) were discharged from the emergency department. Two hundred seventy-eight patients (85%) arrived by ambulance, 36 (11%) arrived by car, and 12 (4%) were airlifted by helicopter. Two hundred fifty-seven patients (79%) were transferred from another institution. The mean hospital stay for patients admitted to the hospital was 46 hours (range 7–395 hours). The mean hospital stay for patients placed under 23-hour observation status was 18 hours (range 2–43 hours). The reasons for hospitalization longer than 1 day included Child Protective Services involvement in 24 patients and other injuries in 11 patients. Thirteen percent (n = 45) had altered mental status or loss of consciousness by history. No patient had any neurological deficits on examination, and none required neurosurgical intervention. Less than 16% (n = 50) had subsequent outpatient follow-up. These patients were all neurologically intact at the follow-up visit. CONCLUSIONS Hospitalization is not necessary for many children with NDSFs. Patients with mental status changes, additional injuries, or possible nonaccidental injury may require observation.
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Zaeem, Faisal, Dalia Giedriemiene, Craig Coleman, Eric Crespo, Joseph Radojevic, Steven Zweibel, Jeffrey Kluger und Christopher A. Clyne. „CRT-D Therapy in Patients with Decompensated NYHA Class-Four CHF“. Cardiology Research and Practice 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/319205.
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Background. ACC-HRS Guidelines for Cardiac Resynchronization Therapy ICD implantation (CRT-D) do not include patients with advanced nonambulatory NYHA class-four CHF due to an expectation of limited survival. There is little data available from these large multicenter randomized studies to support or refute this claim.Purpose. We evaluated the outcomes of patients with advanced nonambulatory NYHA class-four CHF who received CRT-D devices as an attempt to improve the clinical status and promote hospital discharge.Methods. Sixteen (of our six hundred and seventy CRT-D patients) were classified as advanced nonambulatory NYHA Class four inotrope/vasodilator/diuretic-dependent patients. These patients were analyzed retrospectively for weaning success to oral medications, hospital discharge, hemodynamic stability, and survival over eighteen months.Results. Thirteen of sixteen patients were discharged to home within two weeks of implantation. The survival to hospital discharge, as well as at six, twelve, and eighteen months was positive (ninety-four percent, seventy-five percent, sixty-nine percent, sixty-nine percent, resp.). The groups showed significant improvements in systolic blood pressure, renal function, left ventricular ejection fraction, and CHF class.Conclusion. CRT-D in advanced nonambulatory NYHA four patients proved feasible and beneficial. These findings suggest that the strategy merits further study.
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Gani, Yoshua Hardjoni, Beny Alam und Winda Lutfiyanti. „Finite and non-finite verbs in political news: Israeli and Palestinians issues“. LADU: Journal of Languages and Education 1, Nr. 1 (30.11.2020): 29–41. http://dx.doi.org/10.56724/ladu.v1i1.15.
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Background: For centuries, newspapers have delivered news to the reading public informing important events of a day. Specifically, the political news nowadays is more relaxed and popular than other sections, not to mention that it is also presented in an interesting and serious manner.
Purpose: This research aims to classify and determine the verbs whether they are finite or non-finite.
Design and methods: The subjects of the research are political news of “The Jakarta Post” newspaper which have taken and collected from two articles published on Monday, January 27th, 2020 and Tuesday, January 28th, 2020, with the focus on news related to “Donald Trump’s issues between Israeli and Palestinians”. The method used in the research is descriptive qualitative methodology. The main theory of this research are Greenbaum and Nelson (2009), Burton-Roberts (2011), and Lobeck and Denham (2014). The steps in analyzing the data include: (1) collecting the data, (2) categorizing the collected data into their own classifications, (3) analyzing the data, (4) determining the data whether they are finite or non-finite verbs, and finally (5) concluding the data.
Results: The results of the research shows that from the total of two hundred and seventy two findings, there are one hundred and twenty-eight data of finite verbs (47%) and one hundred and forty-four data of non-finite verbs which then are divided into thirty-one –to infinitives (12%), twenty-six bare infinitives (10%), twenty-three passive participles (8%), thirty –ing participles (11%), twelve passive participle forms of be (4%), nine progressive participle forms of be (3%), and thirteen perfect participle forms of have (5%).
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Pritchard, Jon, Julia Brown, Elizabeth Shafford, Giorgio Perilongo, Penelope Brock, Claire Dicks-Mireaux, Jean Keeling, Angela Phillips, Anton Vos und Jack Plaschkes. „Cisplatin, Doxorubicin, and Delayed Surgery for Childhood Hepatoblastoma: A Successful Approach—Results of the First Prospective Study of the International Society of Pediatric Oncology“. Journal of Clinical Oncology 18, Nr. 22 (15.11.2000): 3819–28. http://dx.doi.org/10.1200/jco.2000.18.22.3819.
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PURPOSE: Hepatoblastoma (HB) is a rare malignant liver tumor which occurs almost exclusively in childhood. In the 1970s, survival was approximately 20% to 30%. Since the introduction of cisplatin (PLA) and doxorubicin (DO) into the chemotherapy regimens used to treat these patients, the survival rate has improved dramatically. In most recent studies, primary surgery preceded chemotherapy. In this study by the liver group of the International Society of Pediatric Oncology the aim was to improve survival and reduce operative morbidity and mortality by using preoperative chemotherapy. PATIENTS AND METHODS: After biopsy and assessment of pretreatment extent of disease all patients were treated with continuous 24-hour intravenous infusion of PLA 80 mg/m2 followed by DO 60 mg/m2 over 48 hours (PLADO). After four courses of this chemotherapy, patients were reassessed. Where possible, the primary tumor was resected and treatment completed with two more courses of chemotherapy. RESULTS: One hundred fifty-four patients were registered in the study, and 138 received preoperative chemotherapy. One hundred thirteen (82%) showed a partial response with tumor shrinkage and serial decrease of serum alpha-fetoprotein levels. One hundred fifteen patients had delayed surgery, and 106 (including six with liver transplants) had complete resection of primary tumor. Five-year event-free survival was 66%, and overall survival was 75%. CONCLUSION: This study demonstrates that international collaboration on a large scale is feasible. The toxicity of chemotherapy and morbidity of surgery were acceptable and the overall survival gratifyingly high. We now regard PLADO chemotherapy and delayed surgery to be the best available treatment for children with HB. Other treatment programs should be measured against this standard.
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Land, V. J., J. J. Shuster, W. M. Crist, Y. Ravindranath, M. B. Harris, R. A. Krance, D. Pinkel und D. J. Pullen. „Comparison of two schedules of intermediate-dose methotrexate and cytarabine consolidation therapy for childhood B-precursor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.“ Journal of Clinical Oncology 12, Nr. 9 (September 1994): 1939–45. http://dx.doi.org/10.1200/jco.1994.12.9.1939.
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PURPOSE To compare efficacy and toxicity of two schedules of intermediate-dose methotrexate (IDM) and cytarabine (Ara-C) in remission consolidation of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS In 1986, the Pediatric Oncology Group (POG) began a randomized trial to test two schedules of consolidation chemotherapy in children with newly diagnosed B-precursor cell ALL. MTX and Ara-C were given as overlapping 24-hour infusions. The dose and sequence of MTX and Ara-C administration were based on a preclinical model that had demonstrated synergism between these two agents. Two hundred fifteen patients in complete remission were randomized to front-loading consolidation therapy in which six MTX/Ara-C infusions were administered at 3-week intervals from the 7th through the 19th week of therapy. Two hundred thirteen patients in complete remission were randomized to receive standard consolidation therapy in which the six MTX/Ara-C infusions were given every 12 weeks from the 7th through the 67th week of therapy. RESULTS Both regimens produced similar rates of adverse side effects, except for a higher incidence of CNS toxicity in individuals randomized to the front-loading arm (32 of 215 v 12 of 213 patients, P = .002). Leukoencephalopathy occurred in three patients on the front-loading regimen and was permanent in one. By Kaplan-Meier analysis, the probability of continuing in complete remission for 5 years was 79% (SE = 5%) and 85% (SE = 5%) for good-risk patients, and 66% (SE = 6%) and 61% (SE = 7%) for poor-risk patients randomized to front-loading and standard regimens, respectively. CONCLUSION Although differences in complete remission durations were not statistically significant by log-rank analysis (P = .62 for good-risk patients, .89 for poor-risk patients, and .99 overall), the results are comparable to those in previous studies using more toxic agents as components of remission consolidation therapy.
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Scholl, Jan, und Amy Paster. „Locating, Analyzing and Making Available a Century of 4-H Research Studies, 1911-2011“. Journal of Youth Development 6, Nr. 3 (01.09.2011): 63–79. http://dx.doi.org/10.5195/jyd.2011.175.
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For years, 4-H has emphasized the value of being a research-based youth organization in its long term association with the land-grant university system. But, it was the general consensus among state and national leaders that the program had no research base. The main objectives of this study were to: locate and document research studies conducted (between 1911-2010) in order to support or dispel notions about the lack of 4-H research and its focus on cows and cooking, to make information about the research studies available to the larger community of youth program practitioners and researchers and provide a general review of research topics by decade. Three thousand five hundred and fifty six studies were found over a thirteen year period and only one percent of these related to “cows or cooking.” To make the data available to current and future youth professionals and researchers, the information about each study was transferred to an Internet web-site. Finally, a full century of research topics were summarized.
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Lace, John W., Kristen A. Haeberlein und Paul J. Handal. „Multidimensionality of the Langner Symptom Survey and Replication of a Cutoff Score in Emerging Adults“. Psychological Reports 122, Nr. 1 (30.01.2018): 340–59. http://dx.doi.org/10.1177/0033294118755112.
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This study investigated the dimensionality of the Langner Symptom Survey and replicated a recent finding regarding a clinically validated cutoff score in emerging adults. Nine hundred thirteen (631 females and 282 males) students at a private university in the Midwestern United States participated online as part of a larger study and completed the Langner Symptom Survey and a demographic questionnaire. Results from exploratory principal components and confirmatory factor analyses provided support for both a six- and three-factor model of the Langner Symptom Survey, with the three-factor model offering marginally better confirmatory fit indices and greater parsimony of interpretation. A cutoff score of 5 denoting clinically significant psychological distress and need for treatment was supported through analysis of receiver-operating characteristic, sensitivity, specificity, and total classification accuracy based on psychological service utilization, and this result successfully replicated a recently published finding. The Langner Symptom Survey may function as a multidimensional measure of psychological distress and need for treatment in emerging adults that may need a lexical update.
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Andermahr, Jonas, Hans-Joachim Helling, David Maintz, Stefan Mönig, Jürgen Koebke und Klaus Emil Rehm. „The Injury of the Calcaneocuboid Ligaments“. Foot & Ankle International 21, Nr. 5 (Mai 2000): 379–84. http://dx.doi.org/10.1177/107110070002100504.
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The selective rupture of the calcaneocuboid ligament is extremely rare and frequently misdiagnosed. This study tries to clarify the mechanism, classification and treatment of this entity. The necessity of radiographs with varus stress and in certain cases of computer tomography (CT) and magnetic resonance imaging (MRI), beside the routine antero-posterior and lateral views, is emphasized. Thirteen cases out of five-hundred-twenty-one sprain injuries of the ankle are described, classified and the therapy discussed: If on varus stress radiographs, there is a calcaneocuboid angle <10 degrees without a bony flake (type 1) strapping for six weeks is indicated. A calcaneocuboid angle >10 degrees with or without a small bony flake of the ligament insertion (type 2) should primarily be treated with a shoe cast for 6 weeks; if there are persistent symptoms a secondary peroneus brevis tendon graft is recommended. A calcaneocuboid angle >10 degrees with a big flake (type 3) should be treated by open reduction and refixation of the ligament. Complex injuries (type 4) are characterised by cuboid compression fracture and ligament rupture.
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Lau, S. K., S. Kwan, J. Lee und W. I. Wei. „Source of tubercle bacilli in cervical lymph nodes: A prospective study“. Journal of Laryngology & Otology 105, Nr. 7 (Juli 1991): 558–61. http://dx.doi.org/10.1017/s0022215100116603.
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AbstractA prospective study searching for associated mycobacterial infection of the upper aerodigestive tract in patients with cervical tuberculous lymphadenitis (TBLN) was carried out. One hundred and thirteen patients with a clinical suspicion of cervical TBLN were included. All patients had a physical examination of the upper aerodigestive tract. Routine endoscopy and biopsy of the nasopharynx were performed. All of them had surgery to the cervical lymph node. Seventy-five patients had histologically confirmed cervical TBLN. Culture of the lymph node specimen showed Mycobacterium tuberculosis in 68 (90 per cent). In 45 (60 per cent) patients with cervical TBLN the primary foci of infection could not be found. Twenty-nine (39 per cent) had radiographic evidence of active or healed pulmonary tuberculosis. Sputum culture from two patients showed Mycobacterium tuberculosis. Five patients (six per cent) had tuberculous nasopharyngitis. In one of them (one per cent) the tuberculous nasopharyngitis was primary as no other evidence of mycobacterial infection was found. In the present study, mycobacterial infection of other parts of the upper aerodigestive tract was not found.
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Yusuf, Sholesi Olayinka. „Joint Consultation as A Determinant of Job Satisfaction In The Insurance Sector“. Organization and Human Capital Development 1, Nr. 2 (27.10.2022): 91–107. http://dx.doi.org/10.31098/orcadev.v1i2.1069.
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The urge for employees to have a voice in the decision-making process at the workplace has made joint consultation imperative. This study examined joint consultation as a determinant of job satisfaction in the insurance sector. The study adopted the survey research method using Krejie and Morgan's sample size determination formula to select a sample size of eighty-six (86) from a population of one hundred and ten employees. Seventy-three copies of the questionnaire were duly completed, and thirteen were not usable. Two hypotheses were tested using the partial least square structural equation model, SMARTPLS 3.2.2. SPSS version 25. The result revealed that joint consultation has an effect on employee job satisfaction. The P values for the two hypotheses tested are less than 0.05 level of significance. Therefore, for the two hypotheses, the alternative hypotheses were accepted. The study recommended, among others, that organizations should see joint consultation as a means of enhancing job satisfaction. In addition, further studies should be conducted on joint consultation using other indicators of job satisfaction.
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Umer, Syed Muhammad, Shahbaz Shamim, Khalid Mohammed Khan und Rahman Shah Zaib Saleem. „Perplexing Polyphenolics: The Isolations, Syntheses, Reappraisals, and Bioactivities of Flavonoids, Isoflavonoids, and Neoflavonoids from 2016 to 2022“. Life 13, Nr. 3 (09.03.2023): 736. http://dx.doi.org/10.3390/life13030736.
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Flavonoids, isoflavonoids, neoflavonoids, and their various subcategories are polyphenolics–an extensive class of natural products. These compounds are bioactive and display multiple activities, including anticancer, antibacterial, antiviral, antioxidant, and neuroprotective activities. Thus, these compounds can serve as leads for therapeutic agents or targets for complex synthesis; they are coveted and routinely isolated, characterized, biologically evaluated, and synthesized. However, data regarding the compounds’ sources, isolation procedures, structural novelties, bioactivities, and synthetic schemes are often dispersed and complex, a dilemma this review aims to address. To serve as an easily accessible guide for researchers wanting to apprise themselves of the latest advancements in this subfield, this review summarizes seventy-six (76) articles published between 2016 and 2022 that detail the isolation and characterization of two hundred and forty-nine (249) novel compounds, the total and semisyntheses of thirteen (13) compounds, and reappraisals of the structures of twenty (20) previously reported compounds and their bioactivities. This article also discusses new synthetic methods and enzymes capable of producing or modifying flavonoids, isoflavonoids, or neoflavonoids.
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Sivakumar, Sivaranjani, Rajesh Kesavan und Balachandar Kariappa Reddy. „A prospective observational study of role of pedis scoring in predicting complications of diabetic foot in a tertiary centre“. International Surgery Journal 10, Nr. 4 (31.03.2023): 606–13. http://dx.doi.org/10.18203/2349-2902.isj20230963.
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Background: Diabetes mellitus is one of the most common non-communicable diseases affecting major population in the world. Diabetic foot ulcer still remains the most common manifestation of diabetes mellitus requiring hospitalisation and invariably resulting in increased risk of morbidity. Our aim is to know the usefulness of PEDIS scoring in identifying the severity of diabetic foot ulcer and its management. Methods: In this prospective observational study, data of patients with foot ulcer who came to Apollo hospital in Chennai were collected for one year from July 2021 to May 2022. They were followed up for a period of six months. Patients were assessed and classified according to the PEDIS scoring system. All the data were analyzed by IBM SPSS statistics for windows version 25.0 (IBM corp, Armonk, Newyork USA). All p values <0.05 were considered as statistically significant. Results: Out of one seventy-five patients, one hundred and thirteen were categorized as low risk group with a score between 0-7 and sixty-two as high-risk group with a score between 8-12. Majority of the high-risk groups developed complications like non healing ulcer, osteomyelitis, amputation. It is more prevalent among men with age preponderance for elderly. Whereas management of low-risk groups were limited only to conservative management and debridement. Of twenty-one patients with osteomyelitis, thirteen patients underwent amputation. Conclusions: Based on our study, we have come to a conclusion that the PEDIS scoring system actually helps in grading the diabetic foot and its management.
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Lee, Ji Hye, Hae Sook Kim, Hwi-Joong Yoon und Kun Soo Lee. „Significance of Laminar Air Flow Room for the Reverse Isolation in Neutropenic Cancer Patients.“ Blood 108, Nr. 11 (16.11.2006): 5503. http://dx.doi.org/10.1182/blood.v108.11.5503.5503.
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Abstract Infection is one of the most important causes of death in cancer patients. So many physicians make every effort to control the infection, especially in neutropenic cancer patients. The aim of this study is to find out the role of HEPA filter equipped laminar air flow room reverse isolation for the management of chemotherapy induced febrile neutropenic children with cancer. We evaluated febrile neutropenic patients following chemotherapy from January 2003 to April 2006 at the Department of Pediatrics, Kyungpook National University Hospital, Daegu, Korea. They were promptly managed by antibiotics and antifungal agents and if possible, they were isolated in the aseptic room. They were allocated to three groups of standard ward care, isolation after onset of fever and isolation before onset of fever. Profiles of infection, clinical courses and survival rate were compared among three groups. One hundred and nine episodes of febrile neutropenia from thirty eight cancer patients were observed. Twenty nine were boys and nine were girls with their median age were 5.5 years. The diagnoses included acute leukemia (36.8%), malignant lymphoma (15.8%), and other solid tumor (47.4%). Fifty five episodes were included to standard ward care, forty four episodes to isolation after onset of fever and thirteen episodes to isolation before onset of fever. We found out that one in thirteen episodes of isolation before onset of fever (8%) and twenty six in ninety six episodes in other groups (27%) were microbiologically or clinically defined infections. Fifty six episodes recovered and only one died of infectious cause both isolation after and before onset of fever group, especially all recovered in isolation before onset of fever group. Forty eight episodes recovered and four died in general ward care group, but there was no statistical difference among three groups (p=0.93). Age, sexual difference, underlying disease, absolute neutrophil count (ANC), duration of ANC recovery and incidence of disseminated intravascular coagulation were no difference among three groups. In early isolated group, duration of fever and antibiotics medication were significantly shorter (p=0.002, 0.009) and CRP level was lower than other two groups (p=0.04). Reverse isolation in laminar air flow room for neutropenic cancer children before onset of fever affect the durations of fever and antibiotics treatment with beneficial effect.
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Téllez-Zenteno, José F., Gary Hunter, Lizbeth Hernández-Ronquillo und Edrish Haghir. „Neuroinvasive West Nile Virus Disease in Canada. The Saskatchewan Experience“. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 40, Nr. 4 (Juli 2013): 580–84. http://dx.doi.org/10.1017/s0317167100014700.
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Abstract:Background:West Nile virus (WNV) is a virus of the family Flaviviridae. The main route of human infection is through the bite of an infected mosquito. Approximately 90% of WNV infections in humans are asymptomatic, but neurologic manifestations can be severe.Methods:This study reviews the clinical profile of cases with neuroinvasive West Nile infection (NWNI) reported by the Surveillance program of the government of Saskatchewan in the Saskatoon Health Region (SHR). In 2007, 1456 cases of human West Nile cases were reported by the government of Saskatchewan in the whole province. One hundred and thirteen cases had severe symptoms of NWNI (8%), 1172 (80%) cases had mild symptoms of WNI and 171 (12%) had asymptomatic disease. Three hundred and fifty six cases were reported in the SHR, where 57 (16%) fulfilled criteria for NWNI.Results:From the 57 cases, 39 (68%) were females. Nine (16%) patients had a history of recent camping, two (4%) reported outdoor sports and four (8%) reported outdoor activities not otherwise specified. Twenty five patients had headache (43.9%), 25 confusion (42.1%), 23 meningitis (40.4%), 17 encephalitis (29.8%), 14 encephalopathy (24.6%), 11 meningoencephalitis (19.3%), 10 tremor (17.5%), acute flaccid paralysis 10 (17.5%), myoclonus 1 (1.8%), nystagmus 2 (3.5%), diplopia 2 (3.5%), dizziness 2 (3.5%). Three patients died related with comorbidities during admission.Conclusion:During a year of high occurrence of WNI in Saskatchewan, 16% of cases developed NWNI. The recognition of neurological complications associated with WNI is important to improve their referral to tertiary centers.
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Ceresa, Fabrizio, Fabrizio Sansone und Francesco Patanè. „Role of Preoperative Femoral Artery Color Doppler Echocardiography in Minimally Invasive Cardiac Surgery“. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 7, Nr. 6 (November 2012): 441–44. http://dx.doi.org/10.1177/155698451200700612.
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Objective Minimally invasive cardiac surgery (MICS) through a right thoracotomy has been developed in the past decades, leading to a significant improvement of postoperative outcome. The risk for complications during peripheral cannulation should be considered. We report our experience of preoperative evaluation by color Doppler echocardiography for patients scheduled for MICS. Methods Between January 2009 and December 2011, a total of 155 patients were operated on for mitral valve disease or patent foramen ovale. One hundred thirteen patients were approached by MICS through the fourth intercostal space, and arterial cannulation was peripheral (femoral artery). One hundred nineteen patients scheduled for MICS were screened by ultrasound evaluation before the induction of anesthesia, by means of a vascular linear probe. Three parameters were considered: longitudinal axis, transverse axis, and atherosclerotic disease (AD). Results Peripheral arterial cannulation of vessels greater than 7 mm is safe because we experienced no complications in 69 patients. In case of diameters 6.5 to 7 mm, peripheral cannulation should be avoided in case of presence of calcifications; in fact, three patients in our series with AD had vascular injuries; 25 patients without femoral artery AD had no complications. Cannulation was avoided in six patients with widespread AD. In case of diameters less than 6.5 mm, peripheral cannulation was avoided. Conclusions Peripheral cannulation is safe when a careful preoperative evaluation is performed. The diameters of the femoral vessels are predictors of complications in case of absence of other contraindications.
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Al Zubaidy, Riyadh Z., Khedher I. Khedher und Asaad N. A. Darweesh. „Energy Dissipation on the Ogee Spillways by Using Direction Diverting Blocks“. Journal of Engineering 22, Nr. 3 (01.03.2016): 77–88. http://dx.doi.org/10.31026/j.eng.2016.03.06.
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The purpose of this study is to evaluate the hydraulic performance and efficiency of using direction diverting blocks, DDBs, fixed on the surface on an Ogee spillway in reducing the acceleration and dissipating the energy of the incoming supercritical flow. Fifteen types of DDB models were made from wood with a triangulate shape and different sizes were used. Investigation tests on pressure distribution at the DDBs boundaries were curried out to insure there is no negative pressures is developed that cause cavitation. In these tests, thirty six test runs were accomplished by using six types of blocks with the same size but differ in apex angle. Results of these test showed no negative pressures developed at the boundaries of these blocks. A physical model for a part of Mandili Dam spillway system was constructed with a scale ratio of 1:50. Thirteen runs were carried out to obtain the rating curve of the ogee weir of Mandili Dam Model. Four hundred and seventy test runs were carried out to investigate the performance of the DDBs in reducing the energy of the flow. In these test runs, nine types of blocks with different sizes and different apex angles installed with different configurations on the spillway surface. Thirteen configurations of DDBs were tested. The Froude Number and the location of the hydraulic jump were used as indicators for the efficiency of these DDBs. Results indicated that when using the DDBs on a spillway surface, less Froude Number downstream the spillway is obtained and the hydraulic jump occurs at a much shorter distance from the spillway toe compared to same spillway without DDBs. Depending on the DDBs type, configuration, and the applied discharge, the obtained reduction in Froude Number varied between 4.4 to 19.3% and the reduction in the hydraulic jump distance measured from the spillway toe varied between 54% and 76% compared with that of the standard design of Mandili Dam.
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MOQEET, M. ABDUL, und IMRAN AZAM BUTT. „EXCIMER LASER“. Professional Medical Journal 15, Nr. 01 (10.03.2008): 20–25. http://dx.doi.org/10.29309/tpmj/2008.15.01.2691.
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Objectives: To evaluate the efficacy and safety of excimer laserphotorefractive keratectomy for myopia in Pakistani people. Design: Prospective study. Setting: At Al-Shifa Trust EyeHospital Rawalpindi. Period: October, 1995 and Febrauray, 1996. Material & Methods: The study group of thirteenpatients, comprises of 25 eyes, with refractive error ranging from -1.50 to -3.50 D.S (diopters sphere) and less than-1.50 D.C (diopters cylinder).Results: Thirteen eyes (52%) lost to follow up after three months. Only twelve eyes (48%)could be reviewed at six months after photorefractive keratectomy. At one month, eleven eyes (44%) and at threemonths, eight eyes (32%) were hypermetropic within +0.25 to +1.00 diopters of spherical equivalent .At six months onlythree eyes (25%) had hypermetropia within +0.25 to +1.00 diopters spherical equivalent. None of the eyes had anykind of astigmatism more than 1.00 diopter. No over correction of more than +1.00 diopter of spherical equivalent wasobserved in any case. At one month, three months and six months after photo-refractive keratectomy, 88%, 80% and100% eyes had 6/6 visual acuity respectively, without any optical aid. Hundred percent of the eyes showed completehealing of the epithelium on third post operative day. Moderate to severe postoperative pain was experienced by everyone for three days with gradual reduction in intensity. Only one eye (8.33%) had grade 1 haze at six months. Restsof the eyes were clear .No vision threatening complications occurred. Despite the short term follow up, photorefractivekeratectomy appears to be an effective and safe procedure with good predictability for the correction of low myopia.Conclusion: Despite relatively short term follow up of the study; photo refractive keratectomy (PRK) appears to be safeand quite predictable procedure for correction of low myopia.
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Valenzuela-Méndez, Blanca, Francisco Valenzuela-Sánchez, Juan Francisco Rodríguez-Gutiérrez, Rafael Bohollo-de-Austria, Ángel Estella, Pilar Martínez-García, María Ángela González-García und Jordi Rello. „Plasma Levels of Mid-Regional Proadrenomedullin Accurately Identify H1N1pdm09 Influenza Virus Patients with Risk of Intensive Care Admission and Mortality in the Emergency Department“. Journal of Personalized Medicine 12, Nr. 1 (10.01.2022): 84. http://dx.doi.org/10.3390/jpm12010084.
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Early identification of severe viral pneumonia in influenza virus A (H1N1pdm09) patients is extremely important for prompt admission to the ICU. The objective is to evaluate the usefulness of MR-proadrenomedullin (MR-proADM) compared to C reactive protein (CRP), procalcitonin (PCT), and ferritin in the prognosis of influenza A pneumonia. This prospective, observational, multicenter study included one hundred thirteen patients with confirmed influenza virus A (H1N1pdm09) admitted to an Emergency Department and ICUs of six hospitals in Spain. Measurements and Main Results: one-hundred thirteen patients with confirmed influenza virus A (H1N1pdm09) were enrolled. Seventy-five subjects (mortality 29.3%) with severe pneumonia caused by influenza A H1N1pdm09 virus (H1N1vIPN) were compared with 38 controls (CG).The median MR-proADM levels at hospital admission were 1.2 nmol/L (IQR (0.8–2.6) vs. 0.5 nmol/L (IQR 0.2–0.9) in the CG (p = 0.01), and PCT levels were 0.43 μg/L (IQR 0.2–1.2) in the H1N1vIPN group and 0.1 μg/L (IQR 0.1–0.2) in the CG (p < 0.01). CRP levels at admission were 15.5 mg/dL(IQR 9.2–24.9) in H1N1vIPN and 8.6 mg/dL(IQR 3–17.3) in the CG (p < 0.01). Ferritin levels at admission were 558.1 ng/mL(IQR 180–1880) in H1N1vIPN and 167.7 ng/mL(IQR 34.8–292.9) in the CG (p < 0.01). A breakpoint for hospital admission of MR-proADM of 1.1 nmol/L showed a sensitivity of 55% and a specificity of 90% (AUC-ROC0.822). Non-survivors showed higher MR-proADM levels: median of 2.5 nmol/L vs. 0.9 nmol/L among survivors (p < 0.01). PCT, CRP, and ferritin levels also showed significant differences in predicting mortality. The MR-proADM AUC-ROC for mortality was 0.853 (p < 0.01). In a Cox proportional hazards model, MR-proADM levels > 1.2 nmol/L at hospital admission were significant predictive factors for ICU and 90-day mortality (HR: 1.3). Conclusions: the initial MR-proADM, ferritin, CRP, and PCT levels effectively determine adverse outcomes and risk of ICU admission and mortality in patients with influenza virus pneumonia. MR-proADM has the highest potency for survival prediction.
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Ewurum. „Risk Factors of Skin Diseases among School Children in South Eastern Communities in Nigeria“. West Africa Journal of Medicine 39, Nr. 1 (21.06.2022): 76–82. http://dx.doi.org/10.55891/wajm.v39i1.97.
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Background: Skin disorders frequently seen among primary school children are common causes of morbidity. Determining the risk factors of skin diseases, will enhance a better understanding of skin health and prevent skin diseases in school children.
Aim: To determine the common risk factors of skin diseases among primary school children in Umuahia South Local Government Area of Abia State.
Methods: A descriptive cross-sectional study carried out over a 4-month period among pupils of public and private primary schools. Diagnosis of skin diseases was based on clinical findings as well as laboratory investigations where indicated. A pre-tested, self-administered, close ended questionnaire was used to ascertain the risk factors of skin diseases.
Results: Eight hundred and forty-seven (847) and seven hundred and thirteen (713) subjects were recruited from public and private schools respectively. Fifty-six percent of the subjects were males. The mean age of the study participants was 8.74 ± 2.08 years. The overall prevalence of skin diseases was 40.2%. Using a multivariate logistic regression, gender, number of people per room, frequency of bathing per week and source of water were found to be significant risk factors for skin diseases.
Conclusion: Socio-demographic factors and living conditions are significant risk factors of skin diseases. Standard hygienic practices by school children and their parents/ caregivers will help to reduce the high prevalence of skin diseases in our environment.
Authors
O Ewurum 1, C A Ibeneme 2, T O Nnaji 3, A N Ikefuna 4
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Bubenikova, Jana, Leona Vychodilova, Karla Stejskalova, Jan Futas, Jan Oppelt, Petra Cerna, Martin Plasil und Petr Horin. „The Population Diversity of Candidate Genes for Resistance/Susceptibility to Coronavirus Infection in Domestic Cats: An Inter-Breed Comparison“. Pathogens 10, Nr. 6 (21.06.2021): 778. http://dx.doi.org/10.3390/pathogens10060778.
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Feline coronavirus (FCoV) is a complex pathogen causing feline infectious peritonitis (FIP). Host genetics represents a factor contributing to the pathogenesis of the disease. Differential susceptibility of various breeds to FIP was reported with controversial results. The objective of this study was to compare the genetic diversity of different breeds on a panel of candidate genes potentially affecting FCoV infection. One hundred thirteen cats of six breeds were genotyped on a panel of sixteen candidate genes. SNP allelic/haplotype frequencies were calculated; pairwise FST and molecular variance analyses were performed. Principal coordinate (PCoA) and STRUCTURE analyses were used to infer population structure. Interbreed differences in allele frequencies were observed. PCoA analysis performed for all genes of the panel indicated no population substructure. In contrast to the full marker set, PCoA of SNP markers associated with FCoV shedding (NCR1 and SLX4IP) showed three clusters containing only alleles associated with susceptibility to FCoV shedding, homozygotes and heterozygotes for the susceptibility alleles, and all three genotypes, respectively. Each cluster contained cats of multiple breeds. Three clusters of haplotypes were identified by PCoA, two clusters by STRUCTURE. Haplotypes of a single gene (SNX5) differed significantly between the PCoA clusters.
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DURÁN, GIANNA M., und DOUGLAS L. MARSHALL. „Ready-to-Eat Shrimp as an International Vehicle of Antibiotic-Resistant Bacteria†“. Journal of Food Protection 68, Nr. 11 (01.11.2005): 2395–401. http://dx.doi.org/10.4315/0362-028x-68.11.2395.
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The occurrence of antibiotic-resistant bacteria in foods of animal origin is a potential health threat because resistance can be transferred among bacteria, and antibiotic-resistant pathogens may not respond to antibiotic treatments. Thirteen brands of ready-to-eat shrimp representing four countries of origin were obtained from local grocery stores. Total heterotrophic plate counts were determined, and antibiotic-resistant bacteria were isolated. Total heterotrophic colony counts ranged from 3.3 to 5.6 log CFU/g, which was within approved quality limits. A total of 1,564 isolates representing 162 bacterial species were recovered during screening of resistance to 10 antibiotics: ampicillin, ceftriaxone, chloramphenicol, clindamycin, erythromycin, nalidixic acid, streptomycin, tetracycline, trimethoprim, and vancomycin. Six hundred fifty-seven (42%) of the isolates and 131 (81%) of the species had acquired resistance to antibiotics. Numerous resistant human pathogens were isolated, including Escherichia coli, Enterococcus spp., Salmonella, Shigella flexneri, Staphylococcus spp., and Vibrio spp. Nonresistant Yersinia spp. also were isolated. Ready-to-eat shrimp is sold with instructions to thaw the product before serving, which may result in consumer exposure to antibiotic-resistant bacteria. Widespread trade of this product provides an avenue for international dissemination of antibiotic-resistant pathogens.
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Saraswathy Subramaniam, T. S., Mohd Apandi Apandi, Rohani Jahis, Mohd Samsul Samsudin und Zainah Saat. „Viral Aetiology of Acute Flaccid Paralysis Surveillance Cases, before and after Vaccine Policy Change from Oral Polio Vaccine to Inactivated Polio Vaccine“. Journal of Tropical Medicine 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/814908.
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Since 1992, surveillance for acute flaccid paralysis (AFP) cases was introduced in Malaysia along with the establishment of the National Poliovirus Laboratory at the Institute for Medical Research. In 2008, the Ministry of Health, Malaysia, approved a vaccine policy change from oral polio vaccine to inactivated polio vaccine (IPV). Eight states started using IPV in the Expanded Immunization Programme, followed by the remaining states in January 2010. The objective of this study was to determine the viral aetiology of AFP cases below 15 years of age, before and after vaccine policy change from oral polio vaccine to inactivated polio vaccine. One hundred and seventy-nine enteroviruses were isolated from the 3394 stool specimens investigated between 1992 and December 2012. Fifty-six out of 107 virus isolates were polioviruses and the remaining were non-polio enteroviruses. Since 2009 after the sequential introduction of IPV in the childhood immunization programme, no Sabin polioviruses were isolated from AFP cases. In 2012, the laboratory AFP surveillance was supplemented with environmental surveillance with sewage sampling. Thirteen Sabin polioviruses were also isolated from sewage in the same year, but no vaccine-derived poliovirus was detected during this period.
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EASTWOOD, K., B. J. PATERSON, C. LEVI, R. GIVNEY, M. LOEWENTHAL, T. DE MALMANCHE, K. LAI, J. GRANEROD und D. N. DURRHEIM. „Adult encephalitis surveillance: experiences from an Australian prospective sentinel site study“. Epidemiology and Infection 143, Nr. 15 (13.04.2015): 3300–3307. http://dx.doi.org/10.1017/s0950268815000527.
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SUMMARYFew countries routinely collect comprehensive encephalitis data, yet understanding the epidemiology of this condition has value for clinical management, detecting novel and emerging pathogens, and guiding timely public health interventions. When this study was conducted there was no standardized diagnostic algorithm to aid identification of encephalitis or systematic surveillance for adult encephalitis. In July 2012 we tested three pragmatic surveillance options aimed at identifying possible adult encephalitis cases admitted to a major Australian hospital: hospital admissions searches, clinician notifications and laboratory test alerts (CSF herpes simplex virus requests). Eligible cases underwent structured laboratory investigation and a specialist panel arbitrated on the final diagnosis. One hundred and thirteen patients were initially recruited into the 10-month study; 20/113 (18%) met the study case definition, seven were diagnosed with infectious or immune-mediated encephalitis and the remainder were assigned alternative diagnoses. The laboratory alert identified 90% (102/113) of recruited cases including six of the seven cases of confirmed encephalitis suggesting that this may be a practical data source for case ascertainment. The application of a standardized diagnostic algorithm and specialist review by an expert clinical panel aided diagnosis of patients with encephalitis.
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Quené, Robert-Jan W., und Mark S. Strefeler. „691 (PS 5) INHERITANCE OF QUALITATIVE TRAITS IN NEW GUINEA IMPATIENS“. HortScience 28, Nr. 5 (Mai 1993): 550g—551. http://dx.doi.org/10.21273/hortsci.28.5.550g.
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New Guinea impatiens have been growing in popularity as a potted, bedding and hanging basket plant. This growth has been due mainly to the development of new cultivars by commercial breeding programs. However, no one has investigated or reported the inheritance of simple Mendelian traits of economic importance.A study of the genetics of six qualitative traits was undertaken to elucidate inheritance of these traits in New Guinea impatiens. The traits studied were flower color, flower size, leaf color, leaf vein color, leaf variegation and variegation of leaf margins. Thirteen genotypes were used as parents in reciprocal crosses of all possible combinations. Fourteen crosses yield sufficient seed for use in the inheritance studies. Fifty to one hundred progeny were used from each cross. Segregation of the traits of interest were observed in the F1 populations. Inheritance measures were based on the segregation pattern of the F1 progeny.Heritabilities for traits varied widely. Genetic models based on segregation ratios will be presented for each trait. The mode of inheritance and heritabilities revealed from this study will be useful to plant breeders in developing efficient cultivar improvement strategies.
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Tresoldi, Alberto Stefano, Giulia Carosi, Nazarena Betella, Giulia Del Sindaco, Rita Indirli, Emanuele Ferrante, Elisa Sala et al. „Clinically Nonfunctioning Pituitary Incidentalomas: Characteristics and Natural History“. Neuroendocrinology 110, Nr. 7-8 (13.09.2019): 595–603. http://dx.doi.org/10.1159/000503256.
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Introduction: Available data on pituitary incidentalomas mostly derive from small-scale studies, with heterogeneous inclusion criteria and limited follow-up. No paper has focused specifically on clinically nonfunctioning pituitary incidentalomas (CNFPIs). Objective: To describe the characteristics and the natural history of patients diagnosed with CNFPIs. Methods: Retrospective multicenter cohort study evaluating hormonal, imaging, and visual field characteristics at diagnosis and during follow-up of CNFPIs investigated in 2 Pituitary Centers. Results: Three hundred and seventy-one patients were included (50.9% microadenomas, 35.6% males). Men were older and more likely to have a macroadenoma (p < 0.01). Totally, 23.7% of patients presented secondary hormonal deficits (SHDs), related to tumor size (higher in macroadenomas; p < 0.001) and age (higher in older patients; p < 0.001). Hypogonadism was the most frequent SHD (15.6%). Two hundred and ninety-six patients had follow-up data, 29.1% required surgery after first evaluation, and 97 had at least 3 years of follow-up. In total, 15.3% adenomas grew (more macroadenomas), but only in microadenomas patients with longer follow-up showed a higher growth trend. Totally, 5.2% of patients developed new SHDs (micro- vs. macroadenomas p = 1.000), and in 60% of them this was not associated with an increase in tumor size. Thirteen additional patients required surgery during follow-up (1 microadenoma at diagnosis). Conclusions: Macroadenomas and age are risk factors for SHD in CNFPIs, which occur at diagnosis in a quarter of patients. During follow-up, macroadenomas tend to grow more often, but microadenomas display higher growth trend as follow-up increases. Deterioration of pituitary function is not always related to adenoma growth.
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C.N., Eze, und Olayiwola B.M. „Soil Parasites Contamination of Jetties in Rivers State, Nigeria“. African Journal of Biology and Medical Research 7, Nr. 1 (20.02.2024): 47–54. http://dx.doi.org/10.52589/ajbmr-avw8xi5d.
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The present study evaluated the Soil Parasites Contamination of Onne jetty, Abuloma jetty, Andoni jetty and Bonny jetty in Rivers State, Nigeria. A total of 200 soil samples from jetties within 0-2cm deep were collected in clean polythene using trowel. Soil samples were analysed using magnesium sulphate floatation and modified Baermann technique for the presence of soil parasites (protozoans and helminths). Out of the two hundred (200) sampled soil from the four jetties, one hundred and fifty-six 156 (78.0%) soil were contaminated with parasites. Bonny jetty had the highest soil contamination 46 (92%) followed by Abuloma 42 (84.0%), Onne 38 (76.0%), Andoni had the least soil contamination 30 (60.0%). However, there was no significant difference in the four jetties (P>0.05). Abuloma jetty had the highest parasites contamination 426 (39.48%), followed by Bonny jetty 296 (27.43%), Andoni jetty 194 (17.98%) and Onne jetty with the least parasite contamination 163 (15.11%). Thirteen soil parasites were recovered: Ascaris lumbricoides had the highest prevalence of 300 (27.8%), followed by Hookworm 164 (15.2%), Balantidium coli 152 (14.09%), Entamoeba histolytica 140 (12.97%), Entamoeba coli 100 (9.27%), Schistosoma mansoni 66(6.12%), Fasciola spp 56 (5.19%), Schistosoma japonicum 42 (3.89%), Strongyloides stercoralis 22 (2.04%), Isospora spp. 21 (1.95%), Toxocara spp 8 (0.74%), Trichuris trichiura 6 (0.56%) and Taenia spp 2 (0.19) with the least prevalence. There was no significant difference among the soil parasites recovered in the four jetties. The findings also showed that Ascaris lumbricoides had the highest average abundance and means intensity of 1.5 (75±42.77epg), followed by Hookworm with average abundance and intensity of 0.82 (41±24.69epg)), Taenia spp 0.01 (0.5±0.5) with the least abundance and intensity.
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Parpinelli, Wiliam, Paulo Segatto Cella, Vaneila Daniele Lenhardt Savaris, Jomara Broch und Ricardo Vianna Nunes. „Dry brewery residue in broiler chickens feed“. Semina: Ciências Agrárias 39, Nr. 4 (02.08.2018): 1707. http://dx.doi.org/10.5433/1679-0359.2018v39n4p1707.
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The residual from the food industry has the potential to replace the traditional ingredients used in animal feed, and the dry brewery residue (DBR) may be an alternative for this purpose. This study aimed to evaluate the use of DBR in the diets of broiler from 22 to 42 days of age. Five hundred and forty-six male broilers were used, with an initial average weight of 865 ± 8 g. The animals were distributed in a completely randomized design, with six levels of DBR inclusion (0, 2, 4, 6, 8, 10%), seven replicates and thirteen animals per experimental unit (EU). Weight gain (WG), average feed intake (AFI) and feed:gain ratio were evaluated. At 42 days of age, blood samples were collected from two broilers of each EU, and one broiler per EU was slaughtered to investigate the intestinal development. DBR interposed the WG and promoted a linear effect in this variable from 22 to 42 days of age. This effect was not observed for AFI. The inclusion of DBR interfered with the serum cholesterol values, showing a quadratic influence at the maximum response for the inclusion of 4.96%. However, the blood parameters of triglycerides, uric acid, creatinine, aspartate aminotransferase, alanine aminotransferase and total protein remained unchanged, regardless of the level of dietary DBR. No changes in villus height and crypt depth were observed by intestinal morphometric evaluation. The inclusion of 10% DBR can be used in a poultry diet, without any damage to the performance, metabolism and development of the broilers.
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Coubard, Olivier A., Kinga M. Ober, Marie Gaumet, Marika Urbanski, Jean-Noël Amato, Vincent Chapron, Nicolas Weiss, Kiyoka Kinugawa, Karin Weissenborn und Dominique Thabut. „Standardization of the psychometric hepatic encephalopathy score in a French population“. PLOS ONE 16, Nr. 9 (10.09.2021): e0257136. http://dx.doi.org/10.1371/journal.pone.0257136.
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The Psychometric Hepatic Encephalopathy Score (PHES) has previously been standardized in thirteen countries on three continents, confirming its status of gold standard test to detect minimal hepatic encephalopathy (MHE). In the meantime, performance has also been shown to vary with variables such as age, education, and barely sex. The present study aimed at standardizing the PHES in a French population. One hundred and ninety-six French healthy participants completed a French version of the paper-and-pencil PHES, involving five tests and six measures. Importantly, the balance was perfect between all levels of the three controlled factors, which were sex, age (seven decade-levels from 20–29 to 80–89 years), and education (two levels below or above 12 years of education). Raw measures were transformed to fit the normal distribution. ANOVAs on transformed variables showed no effect of sex, but an effect of age on all measures, and of education on five measures. Multiple or simple regressions were completed to build up normograms. Thorough analysis of variability within each test failed to find outliers that may bias the results. Comparison between French and seminal German data showed that they highly fitted though cultural and cognitive style specificities could be observed. This is the first study to standardize the PHES in a French population and to extensively explore the effects of sex, age and education using perfectly balanced samples. Subtle differences between countries of the same continent emphasize the need to build up normative data in each country to get accurate PHES in patients.
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Onana, Jean Michel. „The World Flora Online 2020 project: will Cameroon come up to the expectation?“ Rodriguésia 66, Nr. 4 (2015): 961–72. http://dx.doi.org/10.1590/2175-7860201566403.
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Abstract Biodiverse Cameroon has been highlighted as the top country in tropical Africa for plant species diversity per degree square, with a higher diversity than all other West African countries added together, and including two of the top documented centres of plant diversity in Tropical Africa. Despite its reduced taxonomic capacity, with only six active taxonomists a high level of botanical activity in the country has resulted in accomplishments such as the databasing of the YA Herbarium (over 60,000 records), which has an in-country collection coverage of almost 95% of the known plant species that are recorded for Cameroon. Other accomplishments are the Red Data Book of the Flowering Plants of Cameroon, several local checklists and published volumes of the Flore du Cameroun which covers 37% of the country's species. Currently the checklist of Cameroon records 7,850 taxa at species and infraspecific level. Resources are needed to support and heighten the profile of this small botanical community. Already thanks to strong collaboration between Cameroon and renowned botanical institutes of others countries, in particular France and United Kingdom, one hundred and thirteen plant families have been published and would help this country to complete the recording of its biodiversity towards contributing to the World Flora Online 2020 project.
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JIANG, ZHENFENG, YINGPENG HAN, WEILI TENG, YONGGUANG LI, XUE ZHAO, ZHONGCHEN ZHANG, WEIQUN MAN und WENBIN LI. „Impact of epistasis and QTL×environmental interaction on the mass filling rate during seed development of soybean“. Genetics Research 94, Nr. 2 (April 2012): 63–71. http://dx.doi.org/10.1017/s0016672312000286.
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SummarySeed filling rate of soybean has been shown to be a dynamic process in different developmental stages affected by both genotype and environment. The objective of the present study was to determine additive, epistatic and quantitative trait loci (QTLs)×environment interaction (QE) effects of the QTL underlying a seed filling rate of soybean. One hundred and forty-three recombinant inbred lines (RILs) derived from the cross of Charleston and Dongnong 594 were used with 2 years of field data (2004 and 2005). Eleven QTLs with significantly unconditional and conditional additive (a) effect and/or additive×environment interaction (ae) effect at different filling stages were identified. Of them six QTLs showed positive a effects and four QTLs had negative a effects on the seed filling rate during seed development. aa and aae effects of 12 pairs of QTLs were identified by unconditional mapping from the initial stage to the final stage. Thirteen pairs of QTLs underlying the seed filling rate with aa and aae effects were identified by conditional mapping. QTLs with aa and aae (additive×additive×environment) effects appeared to vary at different filling stages. Our results demonstrated that the mass filling rate in soybean seed were under genetic and environmental control.
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Gonzalez, Edgar R., Lori A. Jones, Joseph P. Ornato, Giselle C. Bleecker und Michael J. Strauss. „Adjunctive Medications in Patients Receiving Thrombolytic Therapy: A Multicenter Prospective Assessment“. Annals of Pharmacotherapy 26, Nr. 11 (November 1992): 1383–84. http://dx.doi.org/10.1177/106002809202601110.
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OBJECTIVE: To describe the use of adjunctive therapies in patients with acute myocardial infarction receiving thrombolytic agents. DESIGN: Data were collected prospectively by the study-site investigator or the emergency department physician caring for the patient. Study participation did not influence thrombolytic regimen selection or the adjunctive therapies ordered. SETTING: Thirteen Virginia hospitals representing a cross-section of hospitals in the state. Eleven are urban medical centers; four have graduate medical education programs. PARTICIPANTS: Patients were included in the study if the decision to administer thrombolytic therapy was made in the emergency department. MAIN OUTCOME MEASURES: Concomitant medications administered during the first six hours after initiation of thrombolytic therapy. RESULTS: Two hundred ten patients (aged 57 ± 14.1 y) were evaluated. Ninety-five percent of these patients were treated with tissue plasminogen activator, 3 percent received anisoylated plasminogen streptokinase activator complex, and 2 percent received streptokinase. Ninety-one percent of the patients also received heparin, the most commonly used adjunctive medication; 77 percent concomitantly received lidocaine; 62 percent received aspirin; and only 19 percent received a beta-blocker. CONCLUSIONS: Our data provide a reference point for future studies to determine factors that influence the selection of adjunctive agents for treating patients with acute myocardial infarction receiving thrombolytics.
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Batajoo, Kabita Hada, Trishna Shrestha, Sneha Pradhananga und Shanta Manandhar. „Perception of rotating interns on emergency medicine posting of undergraduate curriculum and future career“. Journal of Patan Academy of Health Sciences 5, Nr. 1 (29.06.2018): 31–34. http://dx.doi.org/10.3126/jpahs.v5i1.24039.
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Introductions: Competency in basic knowledge and skill of emergency care is the fundamental goal of all the medical graduates irrespective of their specialty. The aim of this study is to understand the view of young doctors regarding the importance of emergency medicine (EM) both during internship and undergraduate MBBS curriculum.
Methods: This was a descriptive cross sectional study conducted at emergency department, KIST Medical College, Lalitpur, Nepal, during 2016 to 2017. Interns were asked to fill up preformed questionnaires to explore the effectiveness of the posting and its necessity to integrate in undergraduate medical education.
Results: All the respondent medical interns accepted emergency medicine posting was fruitful. Ninety-six (62.3%) thought one month Emergency Department (ED) posting as appropriate. All the participants thought EM should be included in the undergraduate curriculum (UG). Majority believed it would be appropriate in third year (42%) and final year (42%). One hundred and thirteen (73.4%) wanted to pursue emergency medicine career however 41 (26.6%) were reluctant.
Conclusions: All the interns surveyed accepted emergency medicine to be fruitful and should be included in the undergraduate curriculum with one month emergency department posting, and two thirds wanted to pursue it as future career.
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Turinelli, Vanessa, Giacomo Rossi und Alessandra Gavazza. „Retrospective study of 613 canine cytologically normal bone marrows associated to altered hemograms: Description, possible interpretation and review of the principal physiological hematopoietic mechanisms“. Open Veterinary Journal 13, Nr. 2 (2023): 233. http://dx.doi.org/10.5455/ovj.2023.v13.i2.12.
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Background: In clinical routine, it can happen that to an abnormal hemogram corresponds an unexpected cytological normal bone marrow examination that can be difficult to interpret and to menage. Aim: This cytologically retrospective study wants to evaluate a consistent number of qualitative and quantitative normal bone marrow exams according to the hematological and clinical-pathological data to judge if this normality is by itself a pathologic state. Methods: Six hundred and thirteen bone marrow samples were examined. The bone marrow cytological examinations were performed using morphological and numerical criteria together with a complete hemogram, after the identification of clinical or hematological alterations such as multiple lymph nodes enlarged, positive leishmania serological result, staging of neoplasia, cytopenia, increased number of cells or suspicion of malignant blood disorders. Results: Of the 613 bone marrow samples evaluated, 85 (14%) were classified as normal or without cytological abnormalities; however only 28 (33%) of those cases has a normal hemogram associated, whereas 55 (65%) has one or more cytopenia and 2 (2%) has increased blood cells count. Conclusion: From this study emerge that cytological bone marrow examinations without any morphological or numerical abnormalities are often associated with altered hematological exams and for this reason they should not be considered normal and should lead to other deepened investigations.