Auswahl der wissenschaftlichen Literatur zum Thema „Signature métabolomique“
Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an
Inhaltsverzeichnis
Machen Sie sich mit den Listen der aktuellen Artikel, Bücher, Dissertationen, Berichten und anderer wissenschaftlichen Quellen zum Thema "Signature métabolomique" bekannt.
Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.
Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.
Zeitschriftenartikel zum Thema "Signature métabolomique"
Massy, E., C. Confavreux, J. Ramos, A. Villani und K. Chikh. „Signature métabolomique des patients psoriasiques avec onycholyse : étude PSUPSO“. Revue du Rhumatisme 87 (Dezember 2020): A192. http://dx.doi.org/10.1016/j.rhum.2020.10.333.
Der volle Inhalt der QuelleMartin, J. C., und B. Delplanque. „O05 Une matière grasse laitière technologiquement transformée diminue la sévérité de l’athérosclérose chez le hamster et induit une signature métabolomique spécifique“. Cahiers de Nutrition et de Diététique 46 (Dezember 2011): S23. http://dx.doi.org/10.1016/s0007-9960(11)70026-8.
Der volle Inhalt der QuelleMartin, J. C., und B. Delplanque. „O05 Une matière grasse laitière technologiquement transformée diminue la sévérité de l’athérosclérose chez le hamster et induit une signature métabolomique spécifique“. Nutrition Clinique et Métabolisme 25 (Dezember 2011): S23. http://dx.doi.org/10.1016/s0985-0562(11)70009-7.
Der volle Inhalt der QuellePiedrafita, A., S. Balayssac, A. Casemayou, J. S. Saulnier-Blache, B. Breuil, D. Chauveau, S. Decramer, M. Malet-Martino, J. P. Schanstra und S. Faguer. „Inhibition d’HNF1B dans les cellules tubulaires rénales et métabolomique : une signature proche de l’hypoxie et un nouveau rôle potentiel dans la biosynthèse des phospholipides“. Néphrologie & Thérapeutique 17, Nr. 5 (September 2021): 285. http://dx.doi.org/10.1016/j.nephro.2021.07.305.
Der volle Inhalt der QuelleLécuyer, L., C. Dalle, B. Lyan, M. Petera, M. Lagree, A. Rossary, A. Demidem et al. „Signatures métabolomiques par spectrométrie de masse et risque de cancer du sein“. Nutrition Clinique et Métabolisme 32, Nr. 4 (November 2018): 325–26. http://dx.doi.org/10.1016/j.nupar.2018.09.197.
Der volle Inhalt der QuelleLécuyer, L., C. Dalle, P. Micheau, M. Pétéra, D. Centeno, B. Lyan, C. Morand et al. „Signatures métabolomiques associés à des profils alimentaires spécifiques dans la cohorte SU.VI.MAX“. Nutrition Clinique et Métabolisme 33, Nr. 1 (März 2019): 107–8. http://dx.doi.org/10.1016/j.nupar.2019.01.427.
Der volle Inhalt der Quelle„Brèves: Signature métabolomique de la metformine“. Médecine des Maladies Métaboliques 12, Nr. 5 (September 2018): 454. http://dx.doi.org/10.1016/s1957-2557(18)30126-3.
Der volle Inhalt der QuelleDissertationen zum Thema "Signature métabolomique"
Bailleux, Caroline. „Métabolomique du cancer du sein localisé à haut risque de récidive“. Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://www.theses.fr/2023COAZ6017.
Der volle Inhalt der QuelleBreast cancer is a heterogeneous disease with multiple histological, biological, and molecular subtypes. Several fundamental studies have highlighted the activation of specific metabolic pathways in aggressive breast cancers. The aim of this thesis was to identify a signature or markers of the metabolome in localized breast cancer at high risk of recurrence.Our initial studies were based on the retrospective inclusion of 52 patients with localized breast cancer treated at the Antoine Lacassagne Center in Nice. We also analyzed diagnostic biopsies from a cohort of 49 patients treated with neo-adjuvant chemotherapy at the Georges-François Leclerc Center in Dijon for locally advanced breast cancer. After extraction, separation, and concentration of metabolites from diagnostic biopsies and resected tumors, we performed metabolomic profiling using LC-MS/MS to identify and quantify metabolites relatively, followed by biological and statistical analysis.First, we compared the performance of 5 unsupervised machine learning methods (PCA k-means, sparse k-means, spectral clustering, SIMLR, and k-sparse) to identify groups of breast cancer patients. This analysis was only performed on the cohort from Nice.In Article 1, the clusters obtained using the 5 unsupervised machine learning methods were compared. The five methods identified three groups of patients, distinguished by their supposed prognosis (favorable group 1, intermediate group 2, unfavorable group 3), with different clinical and biological profiles. The SIMLR and K-sparse methods were the most effective in terms of clustering. The most discriminating metabolic pathways were glycolysis, glutaminolysis, and amino acid metabolism. The simulated "in-silico" survival analysis (PREDICT tool) revealed a significant difference between the 3 groups for 5-year and 10-year specific survival.In Article 2, survival analyses were performed based on actual patient survival data. Each patient was assigned to his prognostic group established by the 5 unsupervised machine learning methods. Groups 1 and 2 were combined and compared to group 3. The median follow-up was extended to 85.8 months. Bootstrap optimization was applied. The PCA k-means, K-sparse, and Spectral clustering methods achieved the best results for predicting 2-year progression-free survival. The PCA k-means method had the best performance. However, CSS and OS analyses revealed discrepancies between the 5 unsupervised machine learning methods.Simultaneously, a supervised analysis comparing high-grade tumors to low/intermediate grade tumors was conducted to determine the metabolites involved in tumor aggressiveness (Article 3). The Nice cohort was used as a training cohort, while the Dijon cohort was used for external validation. The metabolomic signature was composed of 12 metabolites. The AUCs for the training and validation cohorts were greater than 0.88. Thus, the model could distinguish high-grade tumors from low/intermediate grade tumors with a probability of nearly 90%. We identified several biomarkers of tumor aggressiveness, such as N1, N12 diacetylspermine and tryptophan catabolites (kynurenine and serotonin), which are involved in inhibiting the immune response.These studies open up new perspectives on the underlying biological mechanisms of tumor aggressiveness. Furthermore, the identified biomarkers will allow the development of new strategies. However, analyses on larger populations are necessary
Chevrier, Geneviève, und Geneviève Chevrier. „Effets physiologiques et signature métabolomique de peptides de saumon et d'acides gras oméga-3 dans un modèle murin du syndrome métabolique“. Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/37193.
Der volle Inhalt der QuelleL’objectif principal des études présentées dans cette thèse était d’étudier les effets physiologiques et mécanistiques d’une fraction de peptides de saumon (SPF) de faible poids moléculaire (molecular weight, MW) combinée ou non avec une huile riche en oméga-3 (fish oil, FO), dans un contexte d’obésité induite par une diète riche en gras et en sucre (high-fat and sucrose diet, HFS). Le modèle de souris utilisé en était un du syndrome métabolique (metabolic syndrome, MetS), la souris LDL-/-/ApoB100/100. Dans l’étude de 3 mois (JN, 2015), nous avons montré que les souris nourries avec le SPF ou à la combinaison (SPF+FO) étaient plus tolérantes au glucose. Elles présentaient également des améliorations de plusieurs conditions généralement associées avec le MetS, soit un meilleur profil lipidique, une diminution de l’inflammation du tissu adipeux épidydimaire et une amélioration de la voie de signalisation de l’insuline hépatique. Ces effets étaient associés à une légère diminution du poids corporel, du poids du foie et de l’efficience alimentaire. Les effets observés in vivo du SPF ont ensuite été validés dans 3 lignées cellulaires. Deuxièmement, nous avons voulu valider les effets du SPF au niveau de la tolérance au glucose après 3 mois de diète. Puis, nous avons exploré les mécanismes derrière les effets bénéfiques du SPF et du FO en analysant le métabolome plasmatique des acylcarnitines (AC) et l’expression de gènes hépatiques. Les niveaux d’adiponectine ainsi que l’expression de plusieurs gènes impliqués dans l’homéostasie du glucose, des lipides, dans l’inflammation et dans la β-oxydation mitochondriale et peroxisomale étaient modulés par le SPF et le FO. Le profil en AC a démontré plusieurs changements causés par le SPF et le FO autant au niveau des AC à courte chaîne qu’à moyenne et longue chaîne. Troisièmement, nous avons une fois de plus validé les effets du SPF au niveau de la tolérance au glucose, mais sur une période de 6 mois. Nous nous sommes concentrés sur le profil métabolomique des acides aminés (AA) plasmatiques et avons tenté de comprendre les changements importants survenus après 6 mois de diète en faisant l’analyse par immunobavardage des protéines et enzymes régulant le catabolisme des acides aminés à chaîne ramifiée (branched-chain amino acids, BCAA). L’utilisation du plasma obtenu au sacrifice à l’état de jeûne et post prandial de notre cohorte de souris nourries pendant 3 mois nous a permis d’évaluer l’association entre la signature métabolomique des AA et les effets physiologiques du SPF. Ces études démontrent le potentiel du SPF jumelé ou non avec le FO dans la prévention de complications reliées à l’obésité, comme l’intolérance au glucose, l’inflammation de bas degré et la dyslipidémie.
The main objective of this thesis was to evaluate the metabolic and mechanistic effects of a low-molecular-weight salmon peptide fraction (SPF) combined or not with omega-3-rich fish oil (FO) in the context of diet-induced obesity (DIO) in a murine model of the metabolic syndrome (MetS), the LDL-/-/ApoB100/100 mouse. In the first study, we have shown that mice fed the SPF alone or in combination with FO (SPF+FO) were more glucose tolerant and had marked improvements in their plasma lipid profile, adipose tissue inflammation and hepatic insulin signaling pathway. These effects were associated with a small reduction in body weight, liver weight and energy efficiency. These in vivo effects were then validated in 3 cell lines. Secondly, we validated once again the beneficial impact of SPF on glucose tolerance after 3 months of diet. We aimed to explore its mechanisms of action by doing an extensive assessment of the acylcarnitine (AC) plasma metabolome and the hepatic gene expression of the mice. We found that adiponectin levels and many hepatic genes involved in inflammation, in glucose and lipid homeostasis and in mitochondrial and peroxisomal β-oxidation were altered with SPF and FO. The AC profile was modified upon dietary treatment with FO and SPF, with significant changes in short-, medium- and long-chain AC. Thirdly, we validated the beneficial effects of SPF on glucose tolerance over a 6- month period, and decided to concentrate on the metabolomic profile of plasma amino acids (AA). We aimed to understand the important alterations that occured after 6-months on diet in the SPF-fed animals. Then we also looked at changes in the proteins and enzymes regulating branched-chain amino acids (BCAA) catabolism in liver, skeletal muscle and epidydimal adipose tissue by Western blotting. The metabolomic analyses of plasma obtained after 3 months of diet in our other cohort of mice gave us the opportunity to evaluate the association between the AA signature and the physiological effects of SPF. These studies show the potential of SPF combined or not with FO as a nutraceutical for the prevention of obesity-related complications, such as glucose intolerance, low-grade inflammation and dyslipidemia.
The main objective of this thesis was to evaluate the metabolic and mechanistic effects of a low-molecular-weight salmon peptide fraction (SPF) combined or not with omega-3-rich fish oil (FO) in the context of diet-induced obesity (DIO) in a murine model of the metabolic syndrome (MetS), the LDL-/-/ApoB100/100 mouse. In the first study, we have shown that mice fed the SPF alone or in combination with FO (SPF+FO) were more glucose tolerant and had marked improvements in their plasma lipid profile, adipose tissue inflammation and hepatic insulin signaling pathway. These effects were associated with a small reduction in body weight, liver weight and energy efficiency. These in vivo effects were then validated in 3 cell lines. Secondly, we validated once again the beneficial impact of SPF on glucose tolerance after 3 months of diet. We aimed to explore its mechanisms of action by doing an extensive assessment of the acylcarnitine (AC) plasma metabolome and the hepatic gene expression of the mice. We found that adiponectin levels and many hepatic genes involved in inflammation, in glucose and lipid homeostasis and in mitochondrial and peroxisomal β-oxidation were altered with SPF and FO. The AC profile was modified upon dietary treatment with FO and SPF, with significant changes in short-, medium- and long-chain AC. Thirdly, we validated the beneficial effects of SPF on glucose tolerance over a 6- month period, and decided to concentrate on the metabolomic profile of plasma amino acids (AA). We aimed to understand the important alterations that occured after 6-months on diet in the SPF-fed animals. Then we also looked at changes in the proteins and enzymes regulating branched-chain amino acids (BCAA) catabolism in liver, skeletal muscle and epidydimal adipose tissue by Western blotting. The metabolomic analyses of plasma obtained after 3 months of diet in our other cohort of mice gave us the opportunity to evaluate the association between the AA signature and the physiological effects of SPF. These studies show the potential of SPF combined or not with FO as a nutraceutical for the prevention of obesity-related complications, such as glucose intolerance, low-grade inflammation and dyslipidemia.
Chao, de la Barca Juan Manuel. „Approche métabolomique des maladies dégénératives de la rétine et du nerf optique. : neuropathie optique héréditaire de Leber, athropie optique dominante et préconditionnement rétinien induit par la lumière The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress Metabolic signature of remote ischemic preconditioning involving a cocktail of amino acids and biogenic amines“. Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0069.
Der volle Inhalt der QuelleWe have conducted a mass spectrometry targeted metabolomics approach, enabling us to quantify 188 metabolites including lipids and more polar molecules. Three condition related to the retina and the optic nerve have been studied: Leber hereditary optic neuropathy (LHON), dominant optic atrophy (DOA) due to OPA1 haploinsufficiency and retina light-induced preconditioning (RLIP). The main results we obtained are: LHON project: Concentrations of the whole pool of amino acid and some sphingomyelins (SM) were diminished whereas those of ten phosphatidylcholines (PC)were increased in fibroblasts carrying a LHON mutation. Fibroblasts from LHON-affected patients showed pharmacologically reversible endoplasmic reticulum stress. DOA project: Variations in the concentration of some lipids, glutamate and polar neuroprotective metabolites suggested pre-symptomatic alterations of the myelin sheath along with axonal metabolic dysfunction of the optic nerve in Opa1 +/-mice. A sexual dimorphism was also observed in the metabolome of the optic nerve. RLIP project: Preconditioning light seemed to elicit acute proteolysis and decreased NO production in the retina. Light stress was also related with lipid remodeling in the retina. A sexual dimorphism was also observed in the retina of control rats. Taken as a whole, our results show that the metabolomics approach is adapted and relevant for the study of the physiopathology of ocular diseases
Sakiou, Sofia. „Caractérisation, traçabilité et contrôle qualité des huiles essentielles de lavandes et de lavandins : Apports des signatures chromatographiques et spectroscopiques“. Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4369/document.
Der volle Inhalt der QuelleLavender and lavandin essential oils (EOs) belong to the heritage of the Mediterranean region. Like any natural or synthetic product with an added value, these EOs must be controlled to justify the quality of the product. This quality control requires the establishment of a reliable analytical methodology. In this study, a new approach using spectroscopic and chromatographic techniques for data processing associated to chemometric tools allows to discriminate lavender and lavandin EOs. This discrimination is carried out thanks to their spectroscopic or chromatographic fingerprints. The interest to use the chiral chromatography combined with polarimetric detection and of acquired chiroptical signature was also studied. This methodology has allowed us to identify metabolomic markers which are paramount to characterize the varieties. The results show that it is possible to discriminate the lavender and lavandin EOs according to their varieties with good accuracy on all of the techniques used
Sakiou, Sofia. „Caractérisation, traçabilité et contrôle qualité des huiles essentielles de lavandes et de lavandins : Apports des signatures chromatographiques et spectroscopiques“. Electronic Thesis or Diss., Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4369.
Der volle Inhalt der QuelleLavender and lavandin essential oils (EOs) belong to the heritage of the Mediterranean region. Like any natural or synthetic product with an added value, these EOs must be controlled to justify the quality of the product. This quality control requires the establishment of a reliable analytical methodology. In this study, a new approach using spectroscopic and chromatographic techniques for data processing associated to chemometric tools allows to discriminate lavender and lavandin EOs. This discrimination is carried out thanks to their spectroscopic or chromatographic fingerprints. The interest to use the chiral chromatography combined with polarimetric detection and of acquired chiroptical signature was also studied. This methodology has allowed us to identify metabolomic markers which are paramount to characterize the varieties. The results show that it is possible to discriminate the lavender and lavandin EOs according to their varieties with good accuracy on all of the techniques used
Bakhta, Oussama. „Métabolites circulants induits par le conditionnement ischémique à distance et mécanismes cardioprotecteurs de la colchicine à la phase aigue de l'infarctus du myocarde Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines Cardioprotective role of colchicine against inflammatory injury in a rat 2 model of acute myocardial infarction“. Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0089.
Der volle Inhalt der QuelleThe introduction of early reperfusion in the acute phase of myocardial infarction has improved the prognosis of patients. However, it induces irreversible damages called ischemia-reperfusion (I / R) injury followed by myocardial metabolic and inflammatory disorders. Remote ischemic conditioning (RIC) on the one hand and pharmacological approaches on the other hand, constitute a hope in the prevention of reperfusion injury against which we do not have validated treatment in humans.The aim of this thesis was to explore cardioprotection strategies in the acute phase of myocardial infarction. Using a metabolomics approach, we identified kynurenine and glycine as RIC-associated metabolites in rat plasmas and confirmed in a cohort of patients. We have also validated in vivo the beneficial effect of kynurenine and glycine in a model of myocardial infarction. We then studied the modulation of the kynurenine pathway in RIC-induced cardioprotection. We observed an activation of the NAD + synthesis pathway associated with deacetylation of hepatic mitochondrial proteins. In a last work carried out in vivo and in vitro, we studied the cardioprotective role of colchicine in I / R and analyzed its immunomodulatory effect and activation of survival pathways
Lecuyer, Lucie. „Signatures métabolomiques associées au risque à long terme de cancers du sein et de la prostate et à l’alimentation dans la cohorte SU.VI.MAX : Nouveaux horizons ouverts par la métabolomique appliquée à l’épidémiologie nutritionnelle“. Thesis, Paris 13, 2019. http://www.theses.fr/2019PA131023.
Der volle Inhalt der QuelleBreast and prostate cancers are among the cancers with the highest incidence worldwide and notably in Western countries. The main current challenges lie in the improvement of understanding of nutrition/health relationships and in the identification of individuals at higher risk long before the development of overt cancer to set up prevention actions. A variety of factors exert an impact on the onset and progression of cancer. Among these, nutrition appears as a key factor, in that it can be modified and acted upon through interventions. It is therefore crucial to assess its contribution. For this purpose,detailed and accurate assessment of nutritional intake is essential. Metabolomics, allowing the identification of endogenous, exogenous and microbial biomarkers, opens new perspectives in nutritional epidemiology. So far, few have studies investigated the impact of overall diet on metabolism and risk of breast and prostate cancer through metabolomic profiling. As part of this thesis, we conducted nested case-controls and cross-sectional studies within the SU.VI.MAX cohort to highlight plasma signatures of breast and prostate cancer risks and of overall diet. Plasma samples were collected at baseline and were analysed using two complementary methods : mass spectrometry coupled with liquid chromatography and proton nuclear magnetic resonance. Participants dietary habits were estimated using repeated 24h dietary records and socio-demographic and lifestyle data were collected from self-administered questionnaires.These investigations highlighted endogenous and microbial metabolites associated with overall diet as well as candidate biomarkers of specific dietary exposures. We also identified endogenous, exogenous and microbial metabolites associated with breast and prostate cancers risk suggesting a metabolic disruption up to 13 years before cancer diagnostic. Furthermore, diet appears to be implicated in the variation in plasma levels of some metabolites discriminating individuals at higher risk of developing breast or prostate cancers. These results need to be replicated in future independent observational and interventional studies. In the future, the identification of robust metabolic signatures of breast and prostate cancers risk, of the impact of diet on metabolism and carcinogenesis, and food intake would contribute to better understand health and environment relationships, to better estimate nutritional exposure or even to contribute to the set-up of new public health recommendations in order to reduce the incidence of these pathologies
Moro, Joanna. „Impact de la déficience en acides aminés indispensables sur le métabolisme protéique et énergétique, et identification de signatures métaboliques“. Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASB001.
Der volle Inhalt der QuelleThe availability of protein sources for human nutri-tion is a major concern due to global demographics, economics and nutritional transitions. Protein intakes must cover the need for nine indispensable amino acids (IAA). It is important that this need is met in order to avoid situations of protein and energy me-tabolism imbalance. Various studies have been de-veloped to determine this need: nitrogen balance, the factorial method, and methods using stable iso-topes. However, these methods are difficult and invasive, and the obtained values of needs present significant differences. It is therefore necessary to develop more precise and non-invasive approaches, such as metabolomics, as recommended by the FAO.The objectives of this thesis are to assess the impact of protein and IAA (lysine and threonine) deficiency on protein and energy metabolism and to identify markers of deficiency for these two amino acids in the growing rat. Severe levels of deficiency (85%; 75%) in protein and lysine and threonine decrease weight and lean mass and increase food intake. These effects are associated with a decrease in protein synthesis and an increase in energy metabolism in low protein diets. These effects seems to be mediated by FGF21. Analyses of metabolomics in urine show that variations in pipecolate and taurine indicate lysine and threonine deficiencies, respectively