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Auswahl der wissenschaftlichen Literatur zum Thema „Sensory organs precursors“
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Zeitschriftenartikel zum Thema "Sensory organs precursors"
Giangrande, A. „Proneural genes influence gliogenesis in Drosophila“. Development 121, Nr. 2 (01.02.1995): 429–38. http://dx.doi.org/10.1242/dev.121.2.429.
Der volle Inhalt der QuelleVan De Bor, V., R. Walther und A. Giangrande. „Some fly sensory organs are gliogenic and require glide/gcm in a precursor that divides symmetrically and produces glial cells“. Development 127, Nr. 17 (01.09.2000): 3735–43. http://dx.doi.org/10.1242/dev.127.17.3735.
Der volle Inhalt der QuelleHartenstein, V., und J. W. Posakony. „Development of adult sensilla on the wing and notum of Drosophila melanogaster“. Development 107, Nr. 2 (01.10.1989): 389–405. http://dx.doi.org/10.1242/dev.107.2.389.
Der volle Inhalt der QuelleReddy, G. V., und V. Rodrigues. „Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch“. Development 126, Nr. 10 (15.05.1999): 2083–92. http://dx.doi.org/10.1242/dev.126.10.2083.
Der volle Inhalt der QuelleVervoort, M., D. J. Merritt, A. Ghysen und C. Dambly-Chaudiere. „Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos“. Development 124, Nr. 14 (15.07.1997): 2819–28. http://dx.doi.org/10.1242/dev.124.14.2819.
Der volle Inhalt der QuelleOkabe, M., und H. Okano. „Two-step induction of chordotonal organ precursors in Drosophila embryogenesis“. Development 124, Nr. 5 (01.03.1997): 1045–53. http://dx.doi.org/10.1242/dev.124.5.1045.
Der volle Inhalt der QuelleBlochlinger, K., L. Y. Jan und Y. N. Jan. „Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila“. Development 117, Nr. 2 (01.02.1993): 441–50. http://dx.doi.org/10.1242/dev.117.2.441.
Der volle Inhalt der Quellezur Lage, P., und A. P. Jarman. „Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors“. Development 126, Nr. 14 (15.07.1999): 3149–57. http://dx.doi.org/10.1242/dev.126.14.3149.
Der volle Inhalt der QuelleBrugmann, Samantha A., und Sally A. Moody. „Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs“. Biology of the Cell 97, Nr. 5 (Mai 2005): 303–19. http://dx.doi.org/10.1042/bc20040515.
Der volle Inhalt der QuelleBeisel, Kirk W., Yesha Wang-Lundberg, Adel Maklad und Bernd Fritzsch. „Development and evolution of the vestibular sensory apparatus of the mammalian ear“. Journal of Vestibular Research 15, Nr. 5-6 (01.11.2005): 225–41. http://dx.doi.org/10.3233/ves-2005-155-601.
Der volle Inhalt der QuelleDissertationen zum Thema "Sensory organs precursors"
Kim, Jang-Mi. „Quantitative live imaging analysis of proneural factor dynamics during lateral inhibition in Drosophila“. Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS585.pdf.
Der volle Inhalt der QuelleLateral inhibition by Notch is a conserved mechanism that regulates the formation of regular patterns of cell fates1. In many tissues, intercellular Delta-Notch signaling coordinates in time and space binary fate decisions thought to be stochastic. In the context of sensory organ development in Drosophila, it has been proposed that fate symmetry breaking between equipotent cells relies on random fluctuations in the level of Delta/Notch2 (or one of their upstream regulators, e.g. YAP1 in the mouse gut3), with small differences being amplified and stabilized to generate distinct fates. Notch-mediated stochastic fate choices may also be biased by intrinsic, i.e. cell history4, or extrinsic factors. Although lateral inhibition has been extensively studied in many developmental contexts, a detailed in vivo analysis of fate and signaling dynamics is still lacking. Here, we used a quantitative live imaging approach to study the dynamics of sensory organ fate specification in the Drosophila abdomen. The accumulation of the transcription factor Scute (Sc), a key regulator of sensory organ formation in the abdomen, was used as a proxy to monitor proneural competence and SOP fate acquisition in developing pupae expressing GFP-tagged Sc. We generated high spatial and temporal resolution movies and segmented/tracked all nuclei using a custom-made pipeline. This allowed us to quantitatively study Sc dynamics in all cells. Having defined a fate difference index (FDI), we found that symmetry breaking can be detected early, when cells expressed very low and heterogeneous levels of Sc. We also observed rare cases of late fate resolution, e.g. when two cells close to each other accumulate high levels of GFP-Scute before being pulled away from each other. Interestingly, we did not observe a rapid decrease in GFP-Sc levels in non-selected cells right after symmetry breaking. Also, the rate of change of FDI values after symmetry breaking appeared to positively correlate with cell-to-cell heterogeneity in Sc levels. Whether increased heterogeneity is causally linked to symmetry breaking remains to be tested. We next addressed if this stochastic fate decision is biased by birth order (as proposed in the context of the AC/VU decision in worms4) or by the size and geometry of cell-cell contacts (as modeling suggested5). We found that neither appeared to significantly influence Notch-mediated binary fate decisions in the Drosophila abdomen. In conclusion, our live imaging data provide a detailed analysis of proneural dynamics during lateral inhibition in Drosophila
Li-Kroeger, David. „Integration of regional and neural transcription factors controls EGF signaling from sensory organ precursor cells during Drosophila development“. University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337351052.
Der volle Inhalt der QuelleTrylinski, Mateusz. „Interplay between Notch signaling and cytokinesis in the Drosophila sensory organ lineage“. Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS470.
Der volle Inhalt der QuelleNotch signaling regulates fate specification in lineages among Metazoans. Although its functional requirement is established, it remains unclear how Notch activity is coordinated with lineage progression to ensure fate specification between each division round. To address this question, I used the division of the Drosophila sensory organ precursor cell (SOP) as an experimental model. During fly development, SOPs divide asymmetrically and generate a pIIa cell where Notch is activated and a pIIb cell where Notch is turned off. Notch signaling is mediated in an intralineage manner where pIIb serves as a signal source for pIIa. Following SOP division, pIIb divides within two hours, thereby constraining pIIa fate acquisition within this time window. In addition, activation of Notch receptors at cytokinesis was shown to be required to specify the pIIa fate prior pIIb division. However, the molecular basis for the Notch-cytokinesis interplay was not determined. During my thesis, I first developed a strategy based on photobleaching and photoconversion of fluorophore-tagged Notch receptors to determine Notch activation site along the pIIa-pIIb interface. By doing so, I demonstrated that, in contrast with former models, Notch receptors were activated at the lateral side of the pIIa-pIIb interface at cytokinesis. Using live-imaging, I then provided evidence that the actin regulator Arp2/3 was recruited to the lateral pIIa-pIIb contact during SOP division to expand the contact area and to activate Notch receptors via Delta endocytosis. Thereby, Arp2/3 couples cytokinesis to Notch activation following SOP division
Cheng, Kai Feng, und 鄭凱丰. „Transcriptome Analysis of Sensory Organ Precursors Genes and Genetic Interaction Analysis of Arp6-Interacting Proteins in Sensory Organ Development“. Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2ft96r.
Der volle Inhalt der QuelleChu, Mu Tzu, und 朱慕慈. „Analysis of Effects of Notch and Prepattern Genes on Sensory Organ Precursor Patterning“. Thesis, 2010. http://ndltd.ncl.edu.tw/handle/69653361702571548062.
Der volle Inhalt der Quelle長庚大學
生物醫學研究所
98
There are two types of bristles on notum of Drosophila melanogaster, macrochaete and microchaete. As Pat Simpson’s report, three prepattern genes, extramacrochaete(emc), hairy(h), and stripe(sr), can restrict the position of SOP for macrochaete; and the SOPs of microchaetes are randomly singled out from PCs through lateral inhibition by Notch signaling pathway. The computer model showed that SOP is much easier singled out from periphery than center of PC, because N signaling is less activated in peripheral PC cells than in central ones. However, in anti-Achaete-labeled proneural cluster, SOPs inclined to distribute in lane1 and lane2. Losing the function of N made PCs wider and the density of SOPs higher than original, but PC cells in lane3 and lane4 still adopted epithelial fate. It’s been shown that prepattern genes can restrict positions of SOPs for macrochaetes and the microchaetes-disarranged phenotype in prepattern genes mutant can also be observed. Further, I examined the SOPs selection for microchaetes and I found that prepattern genes can regulate the rate of SOPs selection processing and repress the cells in midline region to express achaete and to adopt SOP cell fate. Nevertheless, prepattern genes didn’t seem to affect SOP selection in microchaete development.
Papaluca, Arturo. „Asymmetric cell division intersects with cell geometry : a method to extrapolate and quantify geometrical parameters of sensory organ precursors“. Thèse, 2014. http://hdl.handle.net/1866/12060.
Der volle Inhalt der QuelleAsymmetric cell division (ACD) consists in a cellular division during which specific cell fate determinants are distributed preferentially in one daughter cell, which then differentiate from its sibling. Hence, ACD is important to generate cell diversity and is used to regulate stem cells homeostasis. For proper asymmetric distribution of cell fate determinants, the positioning of the mitotic spindle has to be tightly controlled. Frequently, this induces a cell size asymmetry, since the spindle is then not centered during mitosis, leading to an asymmetric positioning of the cleavage furrow. Although small small GTPases have been shown to act directly on the spindle, the exact mechanism controlling spindle positioning during ACD is not understood. Recent studies suggest that an independent, yet uncharacterized pathway is involved in spindle positioning, which is likely to involve an asymmetric regulation of the actin cytoskeleton. Indeed, actin enables spindle anchoring to the cortex. Hence we hypothesize that asymmetric actin contractions during cytokinesis might displace the mitotic spindle and the cleavage furrow, leading to cell size asymmetry. Interestingly, from our preliminary results we observed that cortical blebbing, which is a read-out of cortical tension/contraction, preferentially occurs on the anterior side of the dividing sensory organ precursor (SOP) cells at telophase. Our preliminary data support the idea that Rho small GTPases might be implicated in regulation of the mitotic spindle hence controlling asymmetric cell division of SOP cells. The experimental settings developed for this thesis, for studying regulation of the mitotic spindle orientation and positioning will serve as proof of concept of how geneticist and biochemist experts could design ways to control such process by different means in cancerous cells. The preliminary results from this project open novel insights on how the Rho small GTPases might be implicated in controlling asymmetric cell division hence their dynamics in vivo of such process during SOP development. Furthermore, the assays and the theoretical model developed in this study can be used as background that could serve to design improved quantitative experimental methods for cell biology synchronizing sub-networks of ACD mechanism.
Buchteile zum Thema "Sensory organs precursors"
Jauffred, Bertrand, und Yohanns Bellaiche. „Analyzing Frizzled Signaling Using Fixed and Live Imaging of the Asymmetric Cell Division of the Drosophila Sensory Organ Precursor Cell“. In Methods in Molecular Biology, 19–25. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-510-7_2.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Sensory organs precursors"
Wahiduzzaman, Mujibur Khan, Saheem Absar, Spencer Harp, Kyle Edwards und Nathan Takas. „Fabrication of Polyacrylonitrile Nanofiber Membranes Functionalized With Metal Organic Framework for CO2 Capturing“. In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-50806.
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