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Lemoine, Anaïs. „Étude longitudinale et multiomique à la recherche de biomarqueurs fécaux ou salivaires associés au Syndrome d'Entérocolite Induite par les Protéines Alimentaires (SEIPA) chez l'enfant“. Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS128.pdf.
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Contexte : Le SEIPA est une allergie alimentaire non IgE-médiée particulière, répondant à des critères diagnostiques précis. Le traitement est l'éviction des aliments en cause. Il n'existe pas de biomarqueur sérique confirmant le diagnostic, ou prédisant l'acquisition de la tolérance. Seul le test de provocation par voie orale (TPO) permet d'évaluer régulièrement la tolérance à l'allergène en cause. L'évolution est le plus souvent favorable chez l'enfant vers l'âge scolaire. Cependant, la sévérité des symptômes et l'absence d'IgE spécifiques justifient une recherche sur le SEIPA pour mieux comprendre la physiopathologie. Hypothèses : Le SEIPA serait associé à une dysbiose digestive, une dysimmunité locale au niveau digestif, une inflammation intestinale chronique, et une augmentation de la perméabilité intestinale. L'inflammation et la perméabilité seraient majorées lors d'une réaction allergique aiguë. Après acquisition de la tolérance, tous ces paramètres reviendraient à la normale. Objectifs : Décrire de manière longitudinale les microbiotes fécaux et salivaires des patients pédiatriques avec un SEIPA, pendant l'allergie et après la tolérance, ainsi que des biomarqueurs d'intérêt évaluant l'inflammation, la perméabilité et la dysimmunité digestive, comparativement à une cohorte de référence. Matériels et méthodes : Des prélèvements fécaux et salivaires ont été collectés chez les enfants avec un SEIPA suivi dans plusieurs hôpitaux de l'AP-HP, après le diagnostic sous régime d'éviction, et après acquisition de la tolérance, ainsi que chez des témoins appariés aux mêmes âges (ratio 1:1). Des prélèvements de selles supplémentaires ont également été récoltés avant et après les TPO. La composition du microbiote a été analysée par séquençage du gène de l'ARN r16s (V3-V4). La fonction du microbiote fécal a été estimée par dosage des acides gras à chaine courte (AGCC) (chromatographie en phase gazeuse). La calprotectine fécale, la neurotoxine dérivée des éosinophiles (EDN), les IgA sécrétoires fécales, et la zonuline fécale ont évalué l'inflammation, l'immunité et la perméabilité intestinale (ELISA).Résultats principaux : De décembre 2019 à mai 2023, 38 patients ont été inclus (âge moyen : 1,3 ans). A l'inclusion, les patients allergiques avaient une dysbiose fécale et salivaire, s'exprimant par une diminution de l'alpha-diversité, une béta-diversité différente, plusieurs genres bactériens différents, et une augmentation de l'abondance relative de l'acétate par rapport aux témoins appariés. Les patients allergiques n'avaient pas d'inflammation intestinale sous régime d'éviction (calprotectine, EDN), mais seulement de manière aiguë et transitoire après une réaction allergique. Les taux d'IgA sécrétoires fécales étaient plus élevés chez les patients allergiques que chez les témoins ou chez les patients tolérants. La zonuline était similaire entre les patients et les témoins. Après acquisition de la tolérance, chez les 22 patients devenus tolérants, les microbiotes fécal et salivaire se sont rapprochés partiellement de ceux des témoins. Les AGCC et les IgA sécrétoires se sont normalisés (augmentation de l'abondance relative du butyrate, baisse du taux d'IgA). Conclusions : D'après les résultats de cette cohorte, et selon les données antérieures de la littérature scientifique, les enfants avec un SEIPA ont une dysbiose intestinale avant le début de l'allergie, une dysbiose intestinale et salivaire pendant l'allergie jusqu'à l'acquisition de la tolérance, puis un retour du microbiote proche de celui d'enfants sains. La réponse immunitaire adaptative locale est exagérée au cours de la pathologie, avec une augmentation des IgA sécrétoires fécales chez les individus allergiques par rapport aux témoins, et une normalisation après la tolérance. Le rôle exact de ces IgA n'est pas clairement identifiéBackground: FPIES is a non-IgE-mediated food allergy, meeting precise diagnostic criteria. Treatment involves avoiding the offending food. There is no serum biomarker confirming the diagnosis or predicting the development of tolerance. Only the oral food challenge (OFC) regularly assesses allergenic tolerance. In most cases, children acquire spontaneous tolerance at school age. However, the severity of symptoms and the absence of specific IgE justify research into FPIES to gain a better understanding of the pathophysiology.Hypothesis: FPIES is associated with digestive dysbiosis, local digestive dysimmunity, chronic intestinal inflammation and increased intestinal permeability. Inflammation and permeability are exacerbated during an acute allergic reaction. Once tolerance is acquired, all these parameters return to normal. Objectives: To provide a longitudinal description of the faecal and salivary microbiota of paediatric patients with SEIPA, at the times of allergy and tolerance, as well as biomarkers of interest assessing inflammation, permeability and digestive dysimmunity, compared with a reference cohort. Materials and methods: Faecal and salivary samples were collected from children with FPIES followed in several AP-HP hospitals, after diagnosis on an elimination diet, and after acquiring tolerance, as well as from matched controls at the same ages (1:1 ratio). Additional stool samples were also collected before and after OFC. The composition of the microbiota was analysed by r16s RNA gene sequencing (V3-V4). The function of the faecal microbiota was estimated by measuring short-chain fatty acids (SCFA) (gas chromatography). Faecal calprotectin, eosinophil-derived neurotoxin (EDN), faecal secretory IgA, and faecal zonulin assessed inflammation, immunity and intestinal permeability (ELISA).Main results: From December 2019 to May 2023, 38 patients were included (mean age: 1.3 years). At inclusion, allergic patients had faecal and salivary dysbiosis, expressed as decreased alpha-diversity, different beta-diversity, several different bacterial genera, and increased relative abundance of acetate compared with matched controls. Allergic patients did not have intestinal inflammation on elimination diet (calprotectin, EDN), but only acutely and transiently after an allergic reaction. Levels of faecal secretory IgA were higher in allergic patients than in controls or tolerant patients. Zonulin was similar between patients and controls. After acquiring tolerance, in the 22 patients becoming tolerant, faecal and salivary microbiota partially approximated those of controls. Secretory AGCC and IgA levels normalised (increase in relative butyrate, decrease in IgA). Conclusions: According to the results of this cohort, and to previous data in the scientific literature, children with FPIES have a gut dysbiosis before the onset of allergy, gut and salivary dysbiosis during allergy until the acquisition of tolerance, and then a return of a microbiota close to that of healthy children. The local adaptive immune response is exaggerated during the disease, with an increase in faecal secretory IgA in allergic individuals compared with controls, and normalisation after tolerance. The exact role of this IgA is not clearly identified
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Figueiredo, Nara Grossi Vieira de. „Humberto Serpa: Arquitetura“. Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/16/16133/tde-02072013-183656/.
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Humberto Serpa (n. em 1943) formou-se em arquitetura no ano de 1966 e em urbanismo em 1967 pela Escola de Arquitetura da Universidade Federal de Minas Gerais (EAUFMG). Apesar do reconhecimento unânime de seus pares, arquitetos e artistas, é um arquiteto mineiro quase desconhecido para a história da arquitetura brasileira. Esta dissertação busca identificar e qualificar toda a obra realizada por esse profissional entre o final da década de 1960 até meados da década de 1990, a partir de documentação levantada em seu arquivo. É a primeira sistematização de fôlego desenvolvida sobre seu trabalho. Sua trajetória profissional e os projetos arquitetônicos são apresentados em ordem cronológica de forma a favorecer o entendimento de sua produção e de seu percurso no contexto da arquitetura de Minas Gerais na segunda metade do século 20.Humberto Serpa (b. 1943) graduated in architecture in 1966 and urbanism in 1967 by the School of Architecture, Federal University of Minas Gerais (EAUFMG). Despite the unanimous recognition from his peers, architects and artists, he is an architect from Minas Gerais almost unknown in the history of Brazilian architecture. This dissertation seeks to identify and qualify all the work performed by this professional from the late 1960s to mid-1990s, through the documentation of his archives. It is the first in depth attempt of systematization of his work. His career and architectural projects are presented in chronological order so as to facilitate the understanding of its production and its course in the context of the architecture of Minas Gerais in the second half of the 20th century.
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Kůrečková, Jana. „Analýza produktů SEPA“. Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-85196.
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This thesis deals with the analysis of payment instruments, Single European Payments Area and the development and implementation in the Slovakia and Slovenia. The work defines the meaning and objectives of SEPA. This thesis describes the historical development, legal framework and an overview of the participating sectors in SEPA project. The following are the essential characteristics of basic types of SEPA payment instruments, infrastructures and standardization of SEPA. There is outlined a brief history and organizational structure of the SEPA project in the both the countries, further work is devoted to the characteristics and analysis of individual payment instruments SEPA implementation phase.
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Nafti-Malherbe, Catherine. „L'éducation spécialisée entre rélégation et socialisation : approche comparative d'une SEGPA publique et d'une SEGPA privée“. Bordeaux 2, 1999. http://www.theses.fr/1999BOR21029.
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L'objectif de cette recherche était de démontrer que la SEGPA est à la fois un lien de socialisation et en même temps un lieu de relégation consenti par les agents sociaux. Pour cela, il nous a fallu comprendre comment s'est structuré le champ de l'enfance inadaptée. Qui sont les enseignants qui y enseignent ? Quelles sont leurs trajectoires ? Ce champ s'est considérablement modifié depuis vingt ans. Les observations et les entretiens ont permis de mettre au jour les enjeux qui se jouent au quotidien entre les enseignants spécialisés et les autres, entre les enseignants et les élèves, entre les élèves et les élèves. Il s'avère que les mécanismes sociaux l'emportent bien souvent sur le pédagogique, au détriment de tous les acteurs, et ce, en raison du poids historique et institutionnel.
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Hamza, Taha Mohamed. „Doped ZnO nanostructures for Mid Infrared plasmonics“. Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEC051/document.
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L'objectif de ce travail est de réaliser des substrats pour l’effet SEIRA (surface enhanced IR absorption) pour mesurer de faibles volumes de gaz ambiants possédant une signature moléculaire de 3,3 μm à 5,1 μm en exploitant la forte amplification de champ électrique due à la résonance plasmon de surface localisés. A cette fin, nous avons démontré la modulation des résonances de plasmon de surface localisées MIR (LSPR) dans les nanocristaux de ZnO dopés (NCs) dopés à Ga ou Al ainsi que dans des nanofils (NWs) de ZnO dopés Ga (GZO) et dans des nanofils coeur/coquille de ZnO/GZO. En ce qui concerne l’accordabilité de MIR LSPR dans les NC, nous avons modulé la résonance plasmon de surface dans des NC de ZnO dopés Ga et Al, de 3 à 5 μm en faisant varier la teneur en Al et en Ga de 3 à 9 at.%. L’incorporation des dopants s’est révélée homogène jusqu’à 6%. Au-delà (9%), l’incorporation était fortement hétérogène, révélant que la limite de solubilité était atteinte. Les NC présentent une faible activation des impuretés. L'activation était aussi faible que 8%. Les LSPR présentaient également un fort élargissement (largeur-à-mi-hauteur FWHM). Pour accroitre l'activation des dopants, nous avons synthétisés les NC dans des conditions pauvres en O et en passivant les NC synthétisés dans des conditions riches en O (en les isolant dans des matrices telles que Al2O3 et SiO2). Nous avons ainsi augmenté l'activation de 8% à 20% pour les deux stratégies. De plus, l'incorporation des NC dans les matrices a réduit l'élargissement spectral de moitié (de 2200 cm-1 pour les NC déposés à 1100 cm-1 pour les NC noyés en matrice). En correspondance, les effets d’auto-assemblage des nanocristaux sur leur LSPR ont été modélisés par simulation FDTD. Cela a fourni des indications quant aux mécanismes responsable de l’élargissement inhomogènes des LSPR de nanocristaux de GZO. Outre les nanoparticules, nous avons étudié des nanofils ZnO dopés Ga (GZO) et coeur/coquille (ZnO/GZO) synthétisés par CVD d’organométalliques . La première conclusion importante est que le gallium produit un fort effet surfacatnt lors de la croissance MOCVD de GZO. Au lieu de former des nanofils de section hexagonale, l’introduction de Ga modifie nettement l’énergie de surface des faces latérales et conduit à al formation de structures de type « sapins de Noël ». Ce constat est aussi valable pour les coquilles de GZO déposées sur coeur de ZnO. Dans ce cas, les coquilles démouillent et forment des structures hiérarchiques en branches. Concernant les propriétés optiques de ces objets, les mesures de FTIR-photo acoustiques ont démontré une signature d’absorption reliée à la présence de Ga et pouvant être accordée selon la teneur en Ga. Cette absorption reproduit le comportement d’une résonance plasmon de surface. Cette résonance a pu être accordée de 1600 à 1900 cm-1The scope of this thesis is about developing SEIRA (surface enhanced IR absorption) platform to probe low volumes of environmental gases that possess molecular signature from 3.3 μm to 5.1 μm leveraging the high field amplification of localised surface plasmon resonance (LSPR). To realise SEIRA, we demonstrated tuning MIR LSPR in Al or Ga doped ZnO nanocrystals (NCs) as well as in GZO or core-shell (ZnO/GZO) nanowires (NWs). Regarding tuning MIR LSPR in NCs, we demonstrated tunable MIR LSPR in Ga and Al doped ZnO NCs from 3 to 5 μm varying the Al or Ga content from 3 to 9 at.%. The incorporation of dopant was homogeneous up to 6%. At 9% dopant concentration, the incorporation was inhomogeneous, revealing the solubility limit has been reached. However, the NCs exhibited low activation of impurities. The activation was as low as 8%. The LSPR were characterised by large broadening as well. In order to enhance the dopant activation, we synthesized the NCs in O-poor conditions as well as passivated the NCs fabricated in O-rich condictions (by isolating and embedding them in matrices such as Al2O3 and SiO2 matrices). Both strategies improved the dopant activation from 8% up to 20%. Moreover, for assemblies of NCs dispersed in matrices, the broadening (FWHM) of the LSPR was reduced by half (from 2200 cm-1 in as-deposited NCs to 1100 cm-1 in embedded NCs). Correspondingly, the effect of the self-assembly of the nanocrystals on their LSPR was modeled by FDTD simulation and provided hindsight into the mechanisms responsible for the heterogeneous broadening of the LSPR. Finally, we have studied Ga-doped ZnO (GZO) and core-shell (ZnO/GZO) NW synthesized by MOCVD. The first important conclusion is that Ga plays a major surfactant role during the MOCVD growth of GZO. Instead of leading to hexagonal NWs, the introduction of Ga during the synthesis led to faceted “Christmas-tree” like architectures. The same observation held for core-shell ZnO-GZO nanowires; in the latter case, the GZO shell resulted in a dewetting branched architecture. Regarding their optical properties, photo-acoustic FTIR measurements revealed an absorption feature related to the Ga content, likely to be assigned to a plasmonic effect. This resonance could be tuned from 1600 to 1900 cm
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Bachleda, Jozef. „Analýza implementácie projektu SEPA“. Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-198485.
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The goal of this work is to define and analyze european integration within the payment system of the European Union, with the main focus on project SEPA and its payment instruments. In first part it covers the legislative phase, the general characteristics, goals and advantages of the project, institutions responsible for the implementation and coordintation of the project, EU clearing system and standardization of SEPA payment instruments. Analytical part of thesis focus on description and analysis of economical effects of project and individual SEPA payment instruments and their implementation into national payment system of the EU member states. The last part deal with the issue of implementation of SEPA project in Slovakia.
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Roseiro, Maria Luisa de Bivar Weinholtz. „Characterisation and authentication of Serpa cheese“. Thesis, University of Reading, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288738.
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Marton, Gregory A. (Gregory Adam) 1977. „Sepia : semantic parsing for named entities“. Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/28336.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, February 2004.Includes bibliographical references (p. 123-129).
People's names, dates, locations, organizations, and various numeric expressions, collectively called Named Entities, are used to convey specific meanings to humans in the same way that identifiers and constants convey meaning to a computer language interpreter. Natural Language Question Answering can benefit from understanding the meaning of these expressions because answers in a text are often phrased differently from questions and from each other. For example, "9/11" might mean the same as "September 11th" and "Mayor Rudy Giuliani" might be the same person as "Rudolph Giuliani". Sepia, the system presented here, uses a lexicon of lambda expressions and a mildly context-sensitive parser to create a data structure for each named entity. The parser and grammar design are inspired by Combinatory Categorial Grammar. The data structures are designed to capture semantic dependencies using common syntactic forms. Sepia differs from other natural language parsers in that it does not use a pipeline architecture. As yet there is no statistical component in the architecture. To evaluate Sepia, I use examples tp illustrate its qualitative differences from other named entity systems, I measure component performance on Automatic Content Extraction (ACE) competition held-out training data. and I assess end-to-end performance in the Infolab's TREC-12 Question Answering competition entry. Sepia will compete in the ACE Entity Detection and Tracking track at the end of September.
by Gregory A. Marton.
S.M.
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Eusébio, Marina Laidley Gomes Marques. „Mosteiro de Santa Maria de Seiça“. Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2017. http://hdl.handle.net/10400.5/13953.
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Krtoušová, Zuzana. „Příležitosti firmy Sepia na holandském trhu“. Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-3372.
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Teoretická část práce se zabývá strategickou analýzou vnějšího okolí firmy i firmy samotné s ohledem na možnou zahraniční expanzi. Druhý oddíl této části se věnuje formám vstupů na zahraniční trhy. Praktická část je věnovaná belgické firmě Sepia, která poskytuje kompletní služby spojené řízením propagačních materiálů a pořádáním reklamních akcí. Společnost uvažuje o vstupu na holandský trh. Cílem práce je zhodnotit situaci firmy a její příležitosti na holandském trhu, a doporučit eventuální formu vstupu na tento trh.
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Liu, Wing Pui Amy. „Diversity of the genus Seira (Collembola: Entomobryidae: Seirinae) in the Fynbos and Southern Afrotemperate forest“. Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97778.
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Thesis (MSc)--Stellenbosch University, 2015.ENGLISH ABSTRACT: Soil is one of the most complex and understudied terrestrial habitats, and it comprises a wide range of organisms that affect the functioning of terrestrial ecosystems. Despite the importance of these below-ground fauna, our understanding of this diversity remains limited, especially in the Cape Floristic Region (CFR), where higher plants and other more conspicuous invertebrates have been better represented in the literatures. The main aim of this thesis is to provide the first insights into the taxonomic, cryptic and spatial diversity of one of the more diverse Collembola genera, Seira (Collembola: Entomobryidae: Seirinae), in the Fynbos and Southern Afrotemperate forest habitats of the CFR. Collembola constitute an important component of terrestrial biodiversity and are essential for ecosystem functioning. The thesis is divided into two data chapters. The first data chapter examines the mitochondrial barcoding COI (Cytochrome-c oxidase subunit I) gene of 496 Seira specimens from 41 Fynbos and forest sites. Discrete Molecular Operational Taxonomic Units (MOTUs) are identified within Seira. Furthermore, divergence times are estimated and tentatively used to propose historical triggers for the diversification of Seira. Habitat specificity of Seira is assessed through phylogenetic reconstruction using Parsimony and Bayesian analyses based on the nucleotide and amino acid sequences. Genetic divergence indicates that Seira is composed of at least 91 MOTUs, suggesting that morphological taxonomy has vastly under-estimated the richness of this genus by at least four folds. Most of the MOTUs are highly habitat specific and geographically localised. The reconstruction of an evolutionary time frame of these lineages reveals several deep diversifications in the Miocene and a spate of more recent radiations in the Pleistocene and Holocene. Palaeo-environmental fluctuations and vegetation composition shifts are hypothesised as having increased the environmental complexity of the region and this may have influenced the diversification patterns of Seira. In the second data chapter, the spatial variation of Seira diversity is examined and compared between and within two major habitat types, Fynbos and forest, across nine study sites. Abiotic variables were recorded and compared for the investigation of environmental differences among habitat types. The habitat specificity of Seira is assessed, as well as the relative effects of habitat types and study sites on assemblage structure. Species richness of Seira is higher in Fynbos than in forest, and this could be due to the high heterogeneity of niches and resources created by the steep environmental and floristic gradients in the Fynbos habitats. Perhaps one of the most striking results is the high levels of beta diversity exhibited by Seira. The spatial turnover of the Seira assemblage is complete or nearly complete among and within habitat types across study sites within the CFR. Low dispersal abilities and consequently isolated evolutionary histories may account for the strong assemblage differences within the same habitat type of different study sites. However, the substantial differences in assemblage composition between adjacent habitat types in the same site are likely to be the result of the contrasting abiotic conditions exhibited by the Fynbos and forest habitats, as found by this study. Overall, the results of this thesis suggest that Seira species richness is much greater than previously thought. It follows similar diversity patterns to the well-described and hyper-diverse plant communities of the CFR. Here, for both CFR plants and Seira, the spectacular regional diversity displayed is not the result of high alpha diversity, but rather of substantial beta diversity. Because of the high beta diversity and the fact that only two CFR vegetation types were sampled from a limited number of study sites, I predict that the Seira species richness presented here is but the tip of the iceberg.
AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar
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Brauns, Stephanie [Verfasser]. „Die SEPA-Lastschrift / Stephanie Brauns“. Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2015. http://d-nb.info/1106340310/34.
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Costa, Maysa Paula da. „Atividade biológica da seiva e de compostos extraídos da seiva de Hymenaea courbaril sobre leveduras e fungos filamentosos“. Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tede/4874.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Secondary metabolites that have been discovered from the plant kingdom are major sources of innovative therapeutic agents for infectious diseases. Plants have been demonstrated to present important biological activities and are considered as potential clinical application when show compatibility with the human organism. Hymenaea courbaril Linnaeus var. stilbocarpa a tree known as jatoba, presents chemicals products obtained from their leaves, stem, fruit and seeds that are used in folk medicine. Antimicrobial and cytotoxic activity of this plant is little known. An initial screening was performed to evaluate the in vitro susceptibility to sap and compounds of H. courbaril against dermatophytes and Cryptococcus isolates. The sap and the compound fisetin were more active and thus they were used to determine the in vitro susceptibility against eighteen dermatophytes and twenty-six Cryptococcus isolates. The results of in vitro susceptibility assay showed antifungal activity of H. courbaril against all fungi studied. The sap of H. courbaril showed minimal inhibitory concentrations (MIC) ranging between 32-128 μg/mL for dermatophytes and 8-256 μg/mL for complex C. neoformans yeast. The compound of H. courbaril fisetin inhibited the growth of dermatophytes and of Cryptococcus in concentration of 4-128 μg/ml, and of 8 a 128 μg/ml, respectively. In vitro cytotoxicity assays of sap and compound were performed with fibroblast 3T3-A31 by using the technique of absorption of the dye neutral red. Cytotoxicity assays showed that sap and compound have an low toxicity on these cells. The sap and the compound showed IC50 values of 109 μg/mL of 158μg/mL, respectively. The results of this study are relevant and promising because they show that the “fisetin” present a good biological activity for fungi, and is a compound biocompatible with basal cells of mammals. Products with such concentrations of MIC and IC50 can be considered of great value for further pharmacological studies.
As plantas e seus metabólitos secundários são uma grande fonte de inovação de agentes terapêuticos para inúmeras enfermidades, incluindo doenças infecciosas. Plantas de uso popular apresentam atividade biológica em potencial, sendo que devem ser consideradas a importância da aplicação clínica e a compatibilidade com o organismo humano. Hymenaea courbaril Linnaeus var. stilbocarpa uma árvore conhecida como jatobá, possui produtos químicos obtidos de suas folhas, tronco, frutos e sementes que são usadas na medicina popular, no entanto atividade antifúngica e a citotoxicidade desta planta ainda é pouco conhecida. Uma triagem inicial foi realizada para avaliação da suscetibilidade in vitro com a seiva e compostos de H. courbaril sobre isolados de dermatófitos e Cryptococcus. A seiva e o composto fisetina apresentaram-se mais ativos e desta forma foram usados para determinar a suscetibilidade de dezoito isolados de dermatófitos e vinte e seis de Cryptococcus. A seiva de H. courbaril apresentou concentrações inibitórias mínima (CIMs) que variaram de 32 a 128 μg/mL para os dermatófitos e de 8 a 256 μg/mL para as leveduras do complexo C. neoformans. O composto fisetina foi capaz de inibir os dermatófitos em CIMs que variaram de 4 a 128μg/mL e as leveduras do complexo C. neoformans em CIMs que variaram de 8 a 128 μg/mL. A avaliação da citotoxicidade in vitro com fibroblastos 3T3-A31 foi realizada para a seiva e o composto fisetina usando a técnica de absorção do corante vermelho neutro. Por este método foi possível verificar que a seiva de H. courbaril apresentou um IC50 de 109 μg/mL e o composto de 158μg/mL Os resultados encontrados neste estudo são relevantes e promissores, pois mostram que esta planta apresenta uma boa atividade biológica para fungos, além de possuir um composto isolado biocompatível com celulas basais de mamíferos. Produtos com tais concentrações de CIM e IC50 podem ser considerados de grande valor para posteriores estudos farmacológicos.
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Chobotská, Jitka. „Platební styk a postavení SEPA plateb v něm“. Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-206014.
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The masters thesis Payments and position of SEPA payments in payment systems deals with the transition of the national payment system to SEPA payment instruments in the Czech Republic, which is coming into force this year. Banks will have to fulfil requirement of interoperability and will have to be able to proceed payments in XML form. The theoretical part defines payments by the payment form and territorial payments in the first chapter. In the 2nd chapter, the legal framework with focus on new legislation affecting the completion and implementation of the SEPA requirements is described. The following two chapters are devoted to payment systems in the Czech Republic, European Union and telecommunication network SWIFT. The 5th chapter discusses about the SEPA project, with the main emphasis on the definition of SEPA instruments. The practical part is dedicated to analysis of foreign payment fees in selected banks with a focus on individuals.
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O, brien Caitlin. „Effects of prenatal stress on sepia officinalis“. Thesis, Normandie, 2017. http://www.theses.fr/2017NORMC249/document.
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Le stress prénatal est un sujet d'intérêt éthologique croissant en raison de ses effets sur la santé humaine et le bien-être des animaux. Cette thése de doctorat s’intéresse à la seiche Sepia officinalis, un modèle pratique dans lequel la progéniture en développement peut être séparée de leurs mères pour examiner diverses sources potentielles de stress en isolement expérimental. Plusieurs catégories de facteurs de stress ont été appliquées aux embryons et aux juvéniles et la progéniture résultante a été testée dans une série d'épreuves physiologiques et comportementales. L'objectif était de déterminer si différents types de stress prénatal affectent la seiche et, dans l'affirmative, comment ces effets se transmettent. Les données présentées démontrent que les stresseurs appliqués aux femelles reproductrices (stress maternel), ainsi que les stresseurs appliqués directement aux embryons (stress embryonnaire), affectent le comportement postnatal (y compris la structuration corporelle, la latéralisation cérébrale, la prédation et les schémas d'activité) la mémoire et / ou la neurobiologie (y compris les concentrations et le renouvellement de la monoamine, la taille des différents lobes cérébraux et la division cellulaire). Les résultats mettent en évidence la présence de trois voies par lesquelles le stress peut exercer des effets: sur le nombre de descendants produits par la femelle, la transmission de la femelle à sa progéniture et directement sur la progéniture elle-même. Les expériences ont également démontré qu'un facteur de stress complètement artificiel (lumière forte) affectait un éventail plus large de comportements chez la progéniture qu’un stress naturel (odeur de prédateur). Enfin, les données ont montré que l'environnement d'incubation et d’élevage peuvent également affecter la progéniture et méritent donc une attention particulière dans la formulation et l'interprétation des expériences avec cette espèce. Ces découvertes informent à la fois les pratiques de bien-être des seiches et d'autres céphalopodes (par exemple, réduisent la manipulation pour maximiser la reproduction) et élucident et renforcent les principes éthologiques qui s'appliquent au stress animal en général (par exemple la transmission des effets de stress de la mère à la progéniture). Compte tenu des informations fournies ici et dans de nombreuses autres études, la seiche et d'autres céphalopodes devraient continuer à servir de modèles comportementaux en éthologie et en biologie en généralPrenatal stress is a subject of growing ethological interest due to its effects on human health and animal welfare. This Ph.D. thesis utilizes the cuttlefish Sepia officinalis, a convenient model in which developing offspring can be separated from their mothers to examine various potential sources of stress in experimental isolation. Several categories of stressors were applied to cuttlefish and cuttlefish eggs and the resulting offspring were tested in a range of physiological and behavioral tests. The goal was to determine if various types of prenatal stress affect cuttlefish, and if so, how these effects are transmitted. The data presented demonstrate that both stressors applied to reproducing females (maternal stress), as well as stressors applied directly to embryos (embryonic stress), affected post-natal behavior (including body patterning, brain lateralization, predation and activity patterns), learning, memory and/or neurobiology (including monoamine concentrations and turnover, the size of various brain lobes and cell division). The results highlight the presence of three pathways by which stress can exert effects: on the number of offspring produced by the female, transmission from the female to her offspring and directly on the offspring themselves. The experiments also demonstrated that a completely artificial stressor (bright light) affected a wider range of behaviors in offspring than a natural-occurring one (predator odor). Finally, the data showed that incubation and spawning environment can also affect offspring, and thus deserve attention in the formulation and interpretation of experiments with this species. These findings inform both welfare practices for cuttlefish and other cephalopods (e.g. reduce handling to maximize reproduction) as well as elucidating and reinforcing ethological principles that apply to animal stress in general (e.g. the transmission of stress effects from mother to offspring). Given the insight provided here and in numerous other studies, cuttlefish and other cephalopods should continue to serve as behavioral models in ethology and biology in general
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Seppä, Tiina. „Role of nicotinic acetylcholine receptors in cerebral dopaminergic transmission and expression of Fos protein“. Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/seppa/.
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Varela, Ana Rita Carvalho Monteiro. „O turismo como desencadeante da memória e identidade“. Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2017. http://hdl.handle.net/10400.5/14442.
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Ducrot, Thierry, und Thierry Ducrot. „L'autogestion pédagogique en SEGPA, une voie pour l'autodidaxie“. Phd thesis, Université Paris-Est, 2013. http://tel.archives-ouvertes.fr/tel-00954940.
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En 1791, Condorcet place l'autodidaxie au coeur de son projet d'instruction. Il souhaite donner à chaque citoyen, et en particulier à ceux qui n'ont pas la chance de naître dans un milieu aisé, les moyens de s'instruire par soi-même. L'autodidaxie s'inscrit chez Condorcet dans une triple visée : compensatoire, émancipatoire et autonomisante. L'école doit apprendre à apprendre à se former tout au long de la vie. L'autodidaxie nécessite un apprentissage et le maître doit être un accompagnateur de ce processus. Malheureusement, son projet n'aboutit pas.Quelque deux siècles plus tard, l'autodidaxie est remise au goût du jour et invoquée comme nécessité pour s'adapter en permanence à notre société contemporaine où les savoirs sont devenus un enjeu socio-économique important et pour répondre au contexte de crise des institutions éducatives.Cette thèse est le résultat d'une expérience pédagogique menée durant six années, au collège Evire, en Haute-Savoie. Elle se propose d'explorer les effets d'une pédagogie autogestionnaire visant à favoriser une posture autodidacte chez des élèves en grande difficulté et en échec scolaire, orientés au collège en classe de SEGPA. L'autogestion est alors conçue comme un dispositif pédagogique cherchant à concrétiser les orientations de Condorcet. Cette étude de l'autodidaxie en milieu scolaire a permis de mettre en lumière les richesses et les limites d'une telle pédagogie en fonction des dispositifs institués ou instituants et des modalités d'accompagnement.Mots-clés
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Perkins, Kerry. „Cuttlefish (Sepia officinalis) camouflage in varying environmental conditions“. Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68322/.
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Cephalopods first appeared around 500 million years ago. Since then they have developed from the external shelled ammonites, belemnites and nautiloid's to the soft bodied organisms we find today. By becoming soft bodied, protection which would have been provided by the shell was lost and a different approach to predator avoidance was adopted. Modern day cephalopods such as octopus, squid and cuttlefish frequently use camouflage techniques to avoid detection. In addition to countershading, which is an often used camouflage technique by aquatic species, the presence of chromatophores allow a versatile and rapid response in relation to stimuli. Cuttlefish expression of these chromatic responses can be categorised into chromatic components. It is the intensity and combination of the expression which makes them an interesting organism to study, when looking at how the environment influences camouflage decisions. In this thesis, I present six experiments looking at how external environmental factors influence camouflage in Sepia officinalis. The first experimental chapter looks at how 3D objects and proximity play a role in not only camouflage, but behavioural responses. The first set of experiments discuss how factors such as contrast and size of an object may elicit different responses both behaviourally and chromatically. The proximity of the cuttlefish to the object was then investigated to determine if visual input was a possible cause for the differences. Size of the object, proximity and contrast produced a differing response to that of a cuttlefish on a uniform background. The two subsequent chapters look at differing light information and whether cuttlefish treat these differences similar to that of low contrast. Reaction to turbid and low light levels show similar responses in camouflage, suggesting that similar mechanisms are employed when there is reduced light and high scatter information. In respect to luminance versus reflectance, cuttlefish seem to be able to differentiate between a projected and reflected image where they appear to treat projected images like a lower contrast value. The last experimental chapter investigates motion camouflage in respect to predation. Prey and distance had a large effect on behaviour and how camouflage was expressed. Over greater distances behavioural variance reduced. Darkening of the head region and arm waving was also present over a greater distance. Camouflage varied in relation to background with a more uniform background producing reduced expression when moving. Stationary predation therefore elicits a different response than that of motion camouflage in cuttlefish.
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You, Valérie. „Structure de l'hémocyanine de la seiche sepia officinalis“. Tours, 1998. http://www.theses.fr/1998TOUR3805.
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Ducrot, Thierry. „L’autogestion pédagogique en SEGPA, une voie pour l’autodidaxie“. Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST0010/document.
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En 1791, Condorcet place l’autodidaxie au coeur de son projet d’instruction. Il souhaite donner à chaque citoyen, et en particulier à ceux qui n’ont pas la chance de naître dans un milieu aisé, les moyens de s’instruire par soi-même. L’autodidaxie s’inscrit chez Condorcet dans une triple visée : compensatoire, émancipatoire et autonomisante. L’école doit apprendre à apprendre à se former tout au long de la vie. L’autodidaxie nécessite un apprentissage et le maître doit être un accompagnateur de ce processus. Malheureusement, son projet n’aboutit pas.Quelque deux siècles plus tard, l’autodidaxie est remise au goût du jour et invoquée comme nécessité pour s’adapter en permanence à notre société contemporaine où les savoirs sont devenus un enjeu socio-économique important et pour répondre au contexte de crise des institutions éducatives.Cette thèse est le résultat d’une expérience pédagogique menée durant six années, au collège Evire, en Haute-Savoie. Elle se propose d’explorer les effets d’une pédagogie autogestionnaire visant à favoriser une posture autodidacte chez des élèves en grande difficulté et en échec scolaire, orientés au collège en classe de SEGPA. L’autogestion est alors conçue comme un dispositif pédagogique cherchant à concrétiser les orientations de Condorcet. Cette étude de l’autodidaxie en milieu scolaire a permis de mettre en lumière les richesses et les limites d’une telle pédagogie en fonction des dispositifs institués ou instituants et des modalités d’accompagnement.Mots-clésIn 1791, Condorcet set the self-directed learning at the heart of his education project. He wishes to give every citizen, and in particular to those who are not lucky enough to be born in wealthy families, the means to educate by oneself. For Condorcet, self-directed learning has a triple aim: compensatory, emancipatory and empowering. The school must teach to learn how to educate oneself throughout life. Self-directed learning requires a learning process and the schoolmaster has to be a guide to this process. Unfortunately, his project does not succeed.Some two centuries later, the self-directed learning is being brought up to date and cited as a need to constantly adapt to contemporary society in which knowledge has become an important socio-economic issue as well as a need to respond to the crisis of educational institutions.This thesis is the outcome of an educational experiment that has been conducted for six years in Evire middle school, Haute-Savoie. It will explore the effects of self-education to promote self-taught posture among pupils who are struggling and whose counselling is targeted to secondary school SEGPA classes. Self-directed learning is conceived as an educational device embodying the guidance of Condorcet. The study of self-directed learning in schools has helped to highlight the richness and limitations of such a pedagogy depending on established or establishing plans and ways of supporting them
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MAGARELLI, Mario. „Purification, Characterization and Photodegradation studies of modified sepia melanin (Sepia officinalis). Determination of Eumelanin content in fibers from Alpaca (Vicugna pacos)“. Doctoral thesis, Università degli Studi di Camerino, 2011. http://hdl.handle.net/11581/401862.
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Currently melanins are still enigmatic bio-pigments bearing a structure as well as methods of determination not clearly fixed by the international scientific community. In many respects melanins are unique among biopolymers. The other essential biopolymers, that is proteins, nucleic acids and carbohydrates are chemically well characterized and can be determined using well established methodologies. On the other hand, we still do not have a method of accurately determination of melanin. Basically, the classes of mammalian melanins exist in two chemically distinct forms: the brown to black Eumelanin (Eu) and the yellow to reddish-brown Pheomelanin (Pheo). It is believed that melanin has a photoprotective role in animals. Although melanin has been postulated to act as a cellular antioxidant, little is known about the molecular mechanism of melanin photo-protection. An oxidative insult can produce modifications in the physiochemical characteristics of melanin and compromise its photo protective function. Sepia melanin (Sepia officcinalis)represents 98 % of Eumelanin pigment, and is thus used as standard material for the analysis of melanic black. Commercial sepia melanin (very expensive) is purified according to an unknown procedure. In our research, we carried out studies on the extraction and purification of sepia melanin by acid treatment using different concentrations of hydrochloric acid, under mechanic or ultrasonic agitation. This proved effective in producing a high degree purity sepia melanin then fully characterized by Elemental Analysis (EA), Ultraviolet-Visible (UV-VIS) and Infrared (IR) spectroscopy, Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) for metal ion analysis and quantitative studies of Eu polymers for chemical degradation to PTCA and PDCA by High Performance Liquid Chromatography (HPLC). A first modification of sepia melanin using hydrochloric acid afforded the hydrolysis of the sepia melanin while a second modification, obtained adding different salts, resulted in melanin in the salt form. Sepia melanin stability was studied by photodegradation measurements, UV-Vis absorbance spectra of different melanin solutions were measured before and after ultraviolet exposure. The difference spectra reveal that following ultraviolet exposure, a photo-bleaching effect can be observed in this range. The irradiation with ultraviolet radiation induced significant photochemical alterations in the sepia melanin. The obtained results can be used to extrapolate melanin degradation rates in vivo conditions, including the potential limits of its protective effect in humans.
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Gaston, Michelle Renee. „Localization and organization of fin chromatophore motoneurons in the European cuttlefish sepia officinalis /“. view abstract or download file of text, 2004. http://wwwlib.umi.com/cr/uoregon/fullcit?p3153786.
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Thesis (Ph. D.)--University of Oregon, 2004.Typescript. Includes vita and abstract. Includes bibliographical references (leaves 83-91). Also available for download via the World Wide Web; free to University of Oregon users.
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Rahim, Ikram. „SEPA Clients in A Secure Cloud BankingEnvironment“. Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-117350.
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Finance and Economics are one of the most important elements in the development of nations. Dealing with finances and economies banking industry is the solely dominating industry especially during the 20th century. Along with the development of banking industry, information technology was also emerged and started collaboration with this sector. Moreover, banks shifted all their operations over the network; furthermore, networks and telecommunications were enhanced more. They started offering banking services to its clients by using cloud computing (virtualization). After the introduction of Euro by the EU, a project came into existence called Single Euro Payment Area (SEPA). SEPA is an EU project which is an initiative towards the integration and uniform way of payments and bank transfers within the EU region. Our research project is a part of providing web services to clients in a Secure SEPA banking system. Our research focuses on developing SEPA banking web services for clients. We have developed infrastructure for SEPA banking services. Web clients are going to access the main portal by registering themselves. After registration, a client will create bank account. Bank account will have basic credentials of the client including account number and PIN number. Furthermore, account number and PIN number can be used to check account balance; client can perform transactions and convert the respective currency into Euros. All financial transactions should be dealt in Euros; this is one of the main purposes of our SEPA research project. In the second part of our research, some activities have been performed with Point of Interactin(POI) devices. POI device is communicating with the banking system through wireless or GPRS protocols; client will use SEPA smart card. Smart card will be swapped in the POI device; device will detect the smart card data and will interact with the SEPA system. Smart card data contain client’s credentials, such as amount in the bank account, 16 digit card number, and cash in, cash out in the account, card expiry date etc. The final portion, detecting the smart card data, is left for future work.
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Melzner, Frank. „Systemphysiologische Untersuchungen zur Temperaturtoleranz des gemeinen Tintenfischs Sepia officinalis“. [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=983618216.
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Mattiello, Teresa. „Nitric oxide biogenesis, signalling and roles in Sepia officinalis“. Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522306.
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Townsel, Micheal Eugene. „The electron transfer properties of sigma and sepia melanin“. DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1989. http://digitalcommons.auctr.edu/dissertations/1603.
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The melanocytotoxic phenol, p-hydroxyanisole (monomethylether of hydroquinone, MMEH) is a substrate for mushroom tyrosinase. Kinetic and oxygen electrode studies have been performed compari ng the total (anaerobi c and aerobi c) reaction in the formation of the 1, 2-qui none in the presence and absence of synthetic (Sigma) and "biological" (Sepia) melanin samples. These results show evidence of melanin actively transferring electrons to tyrosi nase; thereby acting as a DOPA-l ike cofactor. These results also reveal major differences in the chemical properties of synthetic and biologically extracted melanin in an in vitro system, thus raising important questions about conclusions that are extended to biological systems, using synthetic melanin.
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Rush, Cassidi. „Unknown and Cryptic Diversity in the Adelpha serpa-group“. Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3138.
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The tropics are host to incredible insect diversity. One of the most charismatic groups that exhibit this diversity are the butterflies. Despite the tropical butterfly fauna being heavily researched, there remains much hidden diversity in the form of undescribed life histories and cryptic species. This is especially true among the species rich Nymphalidae, the brush-footed butterflies. Species in the genus Adelpha are known to be “the most trying taxonomically of all nymphalids” DeVries (1987), and as such are fruitful ground for uncovering unknown diversity. About half of the species within Adelpha have undescribed life histories, while A. serpa stands out within the genus in having remarkably wide host breadth, and thus potentially harbors cryptic diversity. Here we describe the life histories of two species of Adelpha from Costa Rica, and use an integrative approach to clarify species level boundaries within the Adelpha serpa-group. We conclude that A. serpa does not show significant evidence of harboring cryptic species, and appears to be a geographically widespread species and a hostplant generalist. Three additional species within the serpa-group show strong evidence of harboring cryptic species, and further research should be done to clarify these species relationships.
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Bassetto, Nayara Zago. „SEPPA - Sistema Especialista para Planta de Produção de Alcool“. [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267571.
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Orientador: Silvio Roberto AndriettaDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: Neste trabalho foi desenvolvido o sistema especialista SEPPA para auxiliar no projeto de construção ou reforma de uma planta industrial para produção de álcool anidro e hidratado fazendo o dimensionamento dos equipamentos, especificando o consumo de energia, o consumo de água e a produção de vapor. Um sistema Especialista é um software que é projetado e desenvolvido para atender a uma aplicação determinada do conhecimento humano. É capaz de emitir uma decisão, apoiado em conhecimento justificado, a partir de uma base de informações, tal qual um especialista de determinada área do conhecimento humano. Uma vez que é gasto um grande tempo para realização dos cálculos de dimensionamento de equipamentos e que pessoas são suscetíveis a erros por diversos fatores, este trabalho será de grande auxílio a todos os profissionais que trabalham dimensionando equipamentos para produção de álcool diminuindo o tempo de cálculo e detalhamentos, garantindo a certeza e precisão em todas as respostas, preservando e reproduzindo o conhecimento do especialista da área em questão. Utilizou para desenvolvimento das telas de interface com o usuário a linguagem de programação Delphi 5.0 e para armazenamento de dados o sistema de banco de dados Interbase 6.0. O Delphi é uma linguagem de programação orientada a objetos, e nos permite trabalhar com a herança em telas proporcionando agilidade no desenvolvimento destas e na implementação de códigos em opções comuns a todos os formulários. O Interbase é um eficiente e seguro banco de dados Cliente/Servidor relacional. A base de conhecimento do sistema foi adquirida através da experiência acumulada de um Engenheiro Químico, este foi construído para processos contínuos e possui algoritmos contendo cálculos de balanço de massa, balanço de energia e equações cinéticas. Através dos testes realizados o software mostrou ser seguro e apto a projetar uma planta industrial, seus resultados foram coerentes com os dados obtidos através dos cálculos e especificações realizadas por meio de um projeto manual utilizando os mesmos parâmetros de entrada
Abstract: In this work it was developed a Expert System an help in the design to built-up or restaur of building or reform industrial plant for the production of anidro and hydrated alcohol defining the size of the equipments, specifying the energy and water consumption and the vapor production. An Expert System is a software projected and developed to attend a determined application and limited of the humans knowledge. It¿s able to emit a decision, supported at justified knowledge, from the base of information, exactly a specialist of a determined area of the human knowledge. The Expert System has its mechanism supported at the heuristic processes. The reasoning process is made the realization of the importance of the facts and comparing it with information contained in the knowledge accumulated about this facts and hypothesis. This reasoning is always based in the previous accumulated knowledge. A specialist with this process is not able to achieve a right decision if the facts that dispose to apply your previous knowledge are not sufficient, and can arrive at a wrong conclusion in function of many reasons. Since is spent a big time to perform the calculations for the dimensionation of equipments and that people are always susceptible at mistakes for many factors, this work will be of a significant help to all the professionals that working dimension at the equipments to the alcohol production diminishing the time of calculations and details, guaranteeing the right answer and the precision so, preserving and reproducing the specialist knowledge of the area in question. It was utilized for the development the Interface and the language of programation Delphi 5.0 and to the storage of data was used the database Interbase 6.0. Delphi is a language of programation oriented to objects, and it permits to work with the inheritance at hardware¿s providing agility in the development of this and the implementation of codes in common options at all the formularies. Interbase is an efficient and safe database Client/ Server. The base of knowledge of system was acquired through the experience accumulated of chemistry engineers in the design of continuous process and has algorithms containing of mass and energy balances as well as thus kinetic equation. Through the tests carried out the software showed be safe and apt to project an industrial plant, its results were coherent with the data obtained through calculus and specifications realized by means of a manual project using the same entrance parameter
Mestrado
Desenvolvimento de Processos Biotecnologicos
Mestre em Engenharia Química
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Galado, Mariana José Borrelfo. „Serpa promove a qualidade de vida dos cuidadores informais!“ Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/23529.
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Este trabalho pretendeu contribuir para a promoção da Qualidade de Vida dos Cuidadores Informais de idosos no domicílio.
Contexto: O fenómeno envelhecimento acentuará os problemas de dependência dos idosos e consequentemente a necessidade de cuidados informais, porém o ato de cuidar pode condicionar a qualidade de vida dos cuidadores informais.
Objetivos: Promover a capacitação e empoderamento dos cuidadores informais de idosos no domicílio, para a promoção do autocuidado e melhoria da Qualidade de Vida.
Metodologia: Recorreu-se à metodologia do planeamento em saúde e como referencial teórico à Teoria de Déficit de Autocuidado de Orem.
Resultados: Após o diagnóstico da situação constatou-se que os cuidadores informais apresentam déficit de autocuidado sendo evidente a necessidade de participação social.
Conclusão: Através de intervenções de promoção da saúde a nível pessoal, de grupos e organizacionais desenvolveram-se ambientes favoráveis à capacitação dos cuidadores informais; ABSTRACT:
"Serpa Promotes the Quality of Life of Informal Caregivers!"
This study aimed to contribute to the promotion of the Quality of Life of Informal Caregivers of the elderly at home.
Context: The phenomenon of aging will accentuate the problems of dependence of the elderly and consequently the need for informal care, but the act of caring can condition the quality of life of informal caregivers.
Objectives: To promote the empowerment of informal caregivers of the elderly at home, to promote self-care and improve Quality of Life.
Methodology: The methodology of health planning was used as a theoretical reference to Orem's Self-Care Deficit Theory.
Results: After the diagnosis of the situation it was verified that informal caregivers present a deficit of self-care, evidencing the need for social participation.
Conclusion: Through health promotion interventions at a personal, group and organizational level, environments favorable to the training of informal caregivers were developed.
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Szajda-Boulanger, Liliane. „Ecriture et rapport à l'écriture des élèves de SEGPA“. Lille 3, 2005. http://www.theses.fr/2005LIL30026.
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La question des difficultés que rencontrent les élèves de SEGPA face à l'écriture reste une préoccupation récurrente de l'enseignement/apprentissage dans le secteur spécialisé. Dans une optique du comprendre pour agir ensuite, la recherche engagée vise à établir un "état des lieux" de l'écriture et du rapport à l'écriture des élèves à partir de textes en réponse à des consignes se rapportant à une écriture sur soi et à une écriture de fiction, un questionnaire sur l'écriture et l'oral des entretiens. Afin de cerner au mieux l'insécurité scripturale des élèves, sont prises en compte dans une analyse croisée, la thématique des écrits, leur organisation textuelle, leur construction énonciative et leur matérialité dans la graphie et son support. Les résultats permettent d'entamer une réflexion concernant quelques propositions didactiques en vue d'une remédiation de l'écriture
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Berge-Cherfaoui, Véronique. „Sepia : système évolutif de perception pour un robot mobile“. Compiègne, 1992. http://www.theses.fr/1992COMPD541.
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Cette thèse décrit l'étude, la réalisation et l'expérimentation de SEPIA, un système évolutif de perception pour un robot mobile autonome. Ce travail tente d'apporter une contribution au problème de l'autonomie d'un robot mobile face aux problèmes de perception dans un environnement a priori non connu et peu structuré. Le principe de SEPIA est d'intégrer l'ensemble des fonctionnalités (contrôle et la planification, la commande et la perception) d'un robot mobile autonome dans une architecture basée sur des concepts développés en intelligence artificielle distribuée (IAD) dans les systèmes multi-agents. Ces concepts prennent en compte la répartition de la fonction de décision dans plusieurs agents dont le but est de coopérer et de collaborer entre eux pour réaliser un objectif donné. Le comportement du système lors de l'exécution d'une mission est la sélection dynamique des capteurs et des traitements en fonction du contexte - à savoir, l'environnement, les objectifs de la mission et les capacités des ressources du robot. Ce comportement se bâtit sur des schémas du type percevoir pour décider d'une action ou encore décider d'une action pour percevoir. L'expérimentation de SEPIA sur le robot mobile du laboratoire pour des missions classiques du type franchir une porte et accoster le poste de travail a permis de valider le caractère évolutif du système. Cette propriété s'applique non seulement à la capacité d'adapter les moyens sensoriels en fonction du contexte, mais aussi à la capacité d'intégrer à plus ou moins long terme, de nouveaux capteurs, de nouveaux traitements et de nouvelles missions.
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Pereira, António José Patinho. „Estudo sobre liderança nas Escolas do Concelho de Serpa“. Master's thesis, Universidade de Évora - Escola Superior de Educação de Beja, 2007. http://hdl.handle.net/10174/16473.
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Baseado no trabalho seminal de Burns (1978) sobre liderança transformacional, Bass (1985) desenvolveu um modelo de liderança transformacional e transacional referido como “full range leadership model”. Os líderes transformacionais articulam uma visão apelativa e uma missão para as suas organizações, através do empowerment dos seus seguidores, encorajam-nos a desenvolver plenamente o seu potencial, possibilitando contributos mais valiosos para a organização. Usando o modelo de Bass, este estudo investigou como os estilos de liderança evidenciados por cinco líderes de escolas do Concelho de Serpa se relacionam com os resultados da liderança (esforço extra, eficácia e satisfação). Os professores avaliaram os seus líderes preenchendo o Questionário Multifatorial de Liderança (Avolio & Bass, 2004). Apesar da existência de algumas limitações neste estudo, como a dependência das perceções dos professores, os resultados mostram que a liderança transformacional apresenta uma correlação positiva com os resultados; a transacional evidencia uma menor correlação, sendo essa correlação negativa para os comportamentos passivos/recusa. Adicionalmente, os líderes avaliaram-se mais positivamente do que os seus professores em todas as escalas do MLQ. Os líderes de género feminino demonstram comportamentos mais transformacionais do que os de género masculino. /ABSTRACT - Based on Burns’s seminal work (1978) on transformational leadership, Bass (1985) developed a model of transformational and transactional leadership referred to as 'full range leadership model Transformational leaders establish an appealing vision and a mission for their organizations, by empowering their followers, encourage them to develop their full potential and thereby contribute more capably to their organization, Using Bass’s model, our study has investigated the relationship between leadership styles in five schools of Serpa County and leadership outcomes (extra effort, effectiveness and satisfaction). The teachers from these schools have evaluated their school leaders by completing the Multifactor Leadership Questionnaire (Avolio & Bass, 2004). Although we are aware of some limitations of our study, such as the reliance on teacher’s perceptions, the results have shown that a transformational leadership style correlates positively with leadership outcomes; and that a transactional leadership shows a less positive one and a negative correlation with the passive/avoidance behaviours. Additionally, leaders have rated themselves more positively in all MLQ scales, than their teachers did. Female leaders have revealed more transformational behaviours than male leaders.
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Lopes, Thiago Vaz. „Avaliação da ação cicatricial da seiva do Croton lechleri“. Universidade Federal de Pelotas, 2014. http://repositorio.ufpel.edu.br:8080/handle/prefix/3064.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
O proposito deste estudo foi avaliar as propriedades curativas da seiva da espécie Croton lechleri. Uma extensa revisão da literatura foi realizada, e as propriedades tóxicas e medicinais conhecidas foram descritas. No entanto, apesar do grande uso pelas comunidades indígenas, não existe uma validação acadêmica dos efeitos dessa planta na cicatrização de feridas. Foram estudados 90 ratos da linhagem Wistar, com a realização de feridas cutâneas abertas no dorso, tratadas diariamente com Croton lechleri na concentração de 0,1 μg para o grupo I, grupo II com C. lechleri a 1 μg e o grupo III (Controle) com pomada não iônica, sendo realizadas avaliações clínicas, morfométricas, bioquímicas e histológicas aos quatro, sete, 14 e 21 dias de tratamento e estudo tensiométrico aos 21 dias. Na avaliação clínica das feridas aos 14 dias de tratamento, o grupo I apresentou maior presença de tecido de granulação, quando comparado ao controle (p<0,05). No estudo morfométrico, observou-se aos quatro dias de tratamento que o grupo II apresentou uma maior média de área (32,6 mm2) e a menor aos sete dias de tratamento (10,5 mm2) comparada aos demais grupos. Histologicamente o grupo II demostrou aos sete dias, um melhor resultado de suas amostras na fase proliferativa. No estudo tensiométrico, o grupo II apresentou a maior média (4,4065 MPa), não sendo observada diferença estatística com os demais (p>0,05). Os resultados levaram as seguintes conclusões: Com ação cicatrizante, C. lechleri a 1 μg acelera o processo cicatricial levando a diminuição da ferida aos sete dias de tratamento e leva a produção de um tecido capaz de suportar uma maior tensão, apresentando resultados satisfatórios como cicatrizante.
The purpose of this study was to assess the healing properties of Croton lechleri sap. An extensive review of current literature was performed, and the known toxic and medicinal properties were described. However, in spite of widespread use by indigenous communities, there is no academic assessment of the plant´s effect on wound healing. In this light, an experiment with 90 Wistar rats was conducted. Two wound were prepared in the back of each rat, and treated with C. lechleri sap at 0.001%, 0.0001%, and non-ionic cream (Groups I, II, and III respectively). The healing process was then assessed through clinical, morphometric, and histological evaluations of the wounds on days four, seven, 14, and 21, and a tensiometric assessment on the last day. Treatment with C. lechleri seems to have hastened the healing process by day 14, when group I had a greater amount of wounds with granulation tissue than group III (P<0.05). In the morphometric study, group II had larger wounds at day four (32.62 mm²), but presented faster healing and, by day 7, had the smallest area (10.5 mm²). Histologically, group II had a greater number of wounds in the proliferative phase by day 7 and in the tesiometric assay (day 21), this group had the greater rupture strength (4.41 MPa), however, this was not statistically different from other groups (P>0.05). These results considered, it seems clear that the C. lechleri sap at 0.001% hastens the healing process, rapidly reducing wound size within seven days of treatment, and producing a scar tissue capable of resisting greater pressure.
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Voisin, Samuel. „L'enseignement de la proportionnalité en segpa : contraintes, spécificités, situations“. Electronic Thesis or Diss., Bordeaux 2, 2013. http://www.theses.fr/2013BOR22087.
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Cette thèse questionne l'enseignement de la proportionnalité à des élèves de 11 à 16 ans relevant de l'adaptation scolaire et de la scolarisation des élèves handicapés. Les travaux de didactique des mathématiques ont montré l'inaboutissement fréquent du projet d'appropriation de la proportionnalité auprès des élèves jusqu'au collège, et tout particulièrement en ASH.Afin de savoir si une adaptation peut se faire sans dénaturer le savoir, nous proposons donc une progression sur l'enseignement de la proportionnalité en classe de Quatrième SEGPA.Nous insistons sur l'importance de l'organisation des savoirs au sein de cette progression et sur la pertinence des contextes et des valeurs des variables didactiques numériques. Les analyses de nos observations se font dans le cadre de l'analyse statistique implicative, de la Théorie des Situations Didactiques ainsi que de la double approche utilisée dans l'analyse des pratiques des enseignants.La mise en œuvre de la progression construite nécessite pour les enseignants des connaissances mathématiques. Afin de réactiver ces connaissances, nous proposons des représentations symboliques qui illustrent les techniques de résolution de problèmes relevant de la proportionnalité simpleThe purpose of this thesis is to investigate the teaching of proportionality to 11 to 16-year old pupils registered in special-needs schools including pupils with more severe learning disabilities.Studies related to the teaching of mathematics have shown that the understanding of proportionality by pupils up to middle school age and more particularly by children with significant learning difficulties is often inappropriate. In order to find out if an adjustment can be made without any impact on the knowledge requirements, we experimented a teaching plan concerning the learning of proportionality by children with special-needs in the context of our study. We insist on the importance of the organization of the different types of knowledge within this teaching plan and also on the relevance of backgrounds and values of numerical didactical parameters. Analysis of our observations is carried out with statistical implicative analysis, Theory of Didactical Situations and with the frame of the double approach used to analyse the practices of teachers.The implementation of such a teaching plan requires, for teachers, mathematical knowledge. In order to reactivate this knowledge, we propose a symbolic scheme for each resolving technique applied to problems involving direct proportionality
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Voisin, Samuel. „L'ENSEIGNEMENT DE LA PROPORTIONNALITÉ EN SEGPA Contraintes, spécificités, situations“. Phd thesis, Université Victor Segalen - Bordeaux II, 2013. http://tel.archives-ouvertes.fr/tel-00939795.
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Cette thèse questionne l'enseignement de la proportionnalité à des élèves de 11 à 16 ans relevant de l'adaptation scolaire et de la scolarisation des élèves handicapés. Les travaux de didactique des mathématiques ont montré l'inaboutissement fréquent du projet d'appropriation de la proportionnalité auprès des élèves jusqu'au collège, et tout particulièrement en ASH. Afin de savoir si une adaptation peut se faire sans dénaturer le savoir, nous proposons donc une progression sur l'enseignement de la proportionnalité en classe de Quatrième SEGPA. Nous insistons sur l'importance de l'organisation des savoirs au sein de cette progression et sur la pertinence des contextes et des valeurs des variables didactiques numériques. Les analyses de nos observations se font dans le cadre de l'analyse statistique implicative, de la Théorie des Situations Didactiques ainsi que de la double approche utilisée dans l'analyse des pratiques des enseignants. La mise en œuvre de la progression construite nécessite pour les enseignants des connaissances mathématiques. Afin de réactiver ces connaissances, nous proposons des représentations symboliques qui illustrent les techniques de résolution de problèmes relevant de la proportionnalité simple.
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Peyrafort, Manon. „Emotion et prise de décision chez la seiche, Sepia“. Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC259.
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En 2013, les céphalopodes sont intégrés dans la directive européenne 2010/63/UE qui impose aux scientifiques de leur fournir des conditions de bien-être en laboratoire. Or, ils ne disposent d’aucun outil d’évaluation. Les réponses émotionnelles des animaux s’avèrent être de bons indicateurs pour évaluer leur bien-être en captivité. Cette thèse vise donc à identifier des indicateurs comportementaux chez la seiche commune. La seiche réalise des changements d’apparence (chromatiques et texturaux), qui s’apparentent dans leur fonctionnement aux expressions faciales des vertébrés. Ces changements s’observent notamment dans un contexte alimentaire, un contexte propice à l’expression d’émotions. Dans un premier temps, les travaux menés décrivent les changements d’apparence des seiches lors de l’attaque d’une proie pour identifier les composants exprimés. Dans un second temps, ces derniers sont évalués dans des contextes de prédation induisant probablement des émotions de valence et d’intensité différentes, ainsi que dans un contexte social compétitif. Les résultats obtenus mettent en évidence 8 composants (1 textural et 7 chromatiques, dont 3 observés pour la première fois) qui sont exprimés différemment d’une seiche à l’autre et d’un contexte à l’autre. Lors de l’attaque d’une proie, les seiches semblent donc réaliser deux stratégies différentes de camouflage (l’une « chromatique » et l’autre « textural ») dirigées vers un prédateur. Ces stratégies semblent révéler un trait de personnalité. Pour les seiches qui utilisent la première stratégie, l’expression de 6 composants chromatiques semblent corrélés à leurs préférences et à leur motivation. Cette thèse conclut que les changements chromatiques intègrent probablement une composante émotionnelle et propose pour la première fois que les seiches ont des états affectifs, mais sans pouvoir l’affirmer avec certitude. A l’avenir, les composants chromatiques pourraient être proposés comme un outil pour l’évaluation du bien-être des seiches, du moins au niveau alimentaireIn 2013, cephalopods were included in European Directive 2010/63/EU, which requires scientists to provide them with welfare conditions in the laboratory. However, they do not have any evaluation tools. The emotional responses of animals are proving to be good indicators for assessing their welfare in captivity. The aim of this thesis is therefore to identify behavioural indicators in common cuttlefish. Cuttlefish change their appearance (chromatically and texturally) which are similar in function to the facial expressions of vertebrates. These changes are particularly observed in a feeding context, a context that is conducive to the expression of emotions. Firstly, the work described the changes in the appearance of cuttlefish when attacking prey to identify the components expressed. Secondly, these components were evaluated in predation contexts, probably inducing emotions of different valence and intensity, as well as in a competitive social context. The results highlight 8 components (1 textural and 7 chromatic, including 3 observed for the first time) that are expressed differently from one cuttlefish to another and from one context to another. When attacking prey, cuttlefish therefore appear to use two different camouflage strategies (one “chromatic” and the other “textural”) directed towards a predator. These strategies seem to reveal a personality trait. For cuttlefish using the first strategy, the expression of 6 chromatic components seems to correlate with their preferences and motivation. This thesis concludes that chromatic changes probably integrate an emotional component and proposes for the first time that cuttlefish have affective states, but without being able to state it with certainty. In the future, chromatic components could be proposed as a tool for evaluating the welfare of cuttlefish, at least at the feeding level
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Khan, Salman. „Security for SEPA Bank Servers inA Cloud Environment“. Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-117039.
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Due to Information Technology (IT) the world has become a global village. We can get information from anywhere on a single click. IT in banking sector connects banks with each other based on their location. Everyone in global world wants a quick response to any query they make. In Eurozone, within each country, banks are centralized and work very well at a national level. Problem arises when they do transactions outside the country, convert money to other currency, charge bank fee, the time it takes to complete the transaction, and much more. Business committee and ordinary person suffer because they want transactions to be completed within few minutes. Research is carried out on how to solve this issue. European Union took initiative to remove barriers, implement one currency system and connect member states. For this purpose EU launched a Single Euro Payments Area (SEPA) system to facilities people and businessman. Our project focuses on development of such infrastructure, where we can provide solution for their problem. After initial study of this area, we found module for secure server in SEPA system. Therefore we configure appropriate servers, setup connections between them for communication with basic security. After implemen tation of secure server’s platform together with other applications, we developed solution of cross-border transactions named SEPA secure banking, which is our area for banking system. We provide secure communications between SEPA servers in a SEPA secure banking system.
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Buskühl, Martin. „Infrarotellipsometrische Untersuchungen zur oberflächenverstärkten Infrarotabsorption (SEIRA, surface enhanced infrared absorption) /“. [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969092148.
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Kelman, Emma Jane. „Visual perception and camouflage of the common cuttlefish sepia officinalis“. Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444357.
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Fiore, Gabriella. „Sepia officinalis ink defence system : biochemical pathways and NO signalling“. Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409864.
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Lança, Domingas R. salgueiro. „Turismo como factor de desenvolvimento: triângulo turístico Beja/Mértola/Serpa“. Master's thesis, Universidade de Évora, 1997. http://hdl.handle.net/10174/13546.
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“Sem resumo feito pelo autor” - A Região Alentejo é um território com forte identidade, onde se manifestam múltiplas marcas culturais, resultado dos cruzamentos de povos e culturas, onde a sua beleza e sua tranquilidade é encontrada na cálida planície, rica de quietude marcada pelas cores do casario e das paisagens, mas condenada ao insucesso intemporal. Uma Região muito diferente, mas igual a muitas que o desenvolvimento nas sociedades marginalizou, resultado de um paradigma de desenvolvimento (Paradigma Funcionalista), que emergiu com a Revolução Industrial e que se arrasta até aos nossos dias, que contribuiu para uma nova forma de pensar, não podendo deixar de ser referenciada. Com este paradigma surge a ideia de que a base económica é a pedra basilar da actividade humana, levando a reduzir o desenvolvimento ao conceito de crescimento económico, o que resulta na utilização excessiva de indicadores económicos como indices de desenvolvimento. O desejo desse crescimento económico vem provocar uma valorização pela quantidade, em relação á qualidade. Esta ideia direccionada pela quantidade conjuntamente com a valorização do crescimento económico, veio trazer à mente de todos que, para fazer desenvolvimento é necessário passar pelo sector industrial e todo um conjunto de novas tecnologias, desvalorizando-se outros sectores de actividade, como o da agricultura e pecuária. Inicia-se a valorização tecnológica, passando a reger os nossos ritmos e gestos e a substituir o ser humano na lista dos factores fundamentais do desenvolvimento. Dá-se então início ao mito do racionalismo, pois a valorização pelo tecnológico, vai marginalizar outras formas de conhecimento e de vida,
como a afectividade, que de certa forma acaba por levar ao individualismo, este como suporte de sucesso, eixo de competitividade e palco de afirmação. Com este novo tipo de produção (produção em série e valorização do quantitativo) é necessário criar novas necessidades e vícios de consumo para dar resposta à quantidade produzida, criando-se nas sociedades o consumismo. Apesar deste consumismo permitir a diversificação de produtos, jogava também com a aspiração à massificação e à homogeneização, dado todos quererem atingir o tal nível de vida. Ao estar-se por detrás da ideia de olhar para os outros à luz dos seus valores e maneiras de estar, exigindo aos outros que sigam e percorram os mesmos passos e formas de desenvolvimento, caminhando-se para a intolerância e etnocentrismo. (Amaro 1993) Todo este conjunto de forma de estar e pensar veio permitir a deslocação das pessoas do mundo rural para a cidade, encarando a vida no campo ou em meio rural como sinal de subdesenvolvimento. Foi o ponto de partida para o Alentejo e outras regiões serem atiradas para as trevas, preteridas em prol de outras, mais litorâneas, mais cosmopolitas, mais politizadas, proporcionando grandes assimetrias regionais. De facto, o conhecido modelo de desenvolvimento beneficiou somente algumas regiões, os chamados pólos urbanos, perspectivados como local privilegiado do desenvolvimento, inverso do meio rural, encarado como um espaço de ineficiência na utilização dos recursos económicos. Este modelo definiu um desenvolvimento encarado como sinónimo de crescimento económico, resultado de políticas de crescimento a nível de produtividade, do trabalho, entre outros, em que assentava no gerar de riquezas fomentadas no sector industrial. É perceptível que o paradigma evidenciado não favorece os dinamismos dos Homens e as potencialidades endógenas em todas as regiões, mas sim de algumas. Assim, levanta-se uma dúvida - Não será este, apenas um modelo de crescimento económico, ao invés de desenvolvimento e ó para algumas regiões?
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Ejaz, Adnan Hafiz. „Secure Administration of SEPA Servers in A Cloud Environment“. Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-108090.
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Cloud Computing is the emerging way of getting benefit from technology. Cheap solutions motivate everyone to put their heads into the wheel at least once to increase their output. Cloud computing provides three difierent levels of services. SaaS, PaaS and IaaS, which are very attractive for consumers. This attraction is also very charming for banking industry, as cloud computing suits this industry in many ways. Banks do not need to spend money on IT resources and can get all within a cloud. However, it is not so easy in adoption, as it seems in words. Many genuine concerns arise about how banks can work in such environment. There are many risks to face (data and credentials security, privacy) which can only be understood after working in such an environment. Our research focuses on development of such an infrastructure where we can test these risks and address their solutions. After the initial study in this area, we found the service model of cloud computing, which suits the best banking industry, is IaaS. Therefore, we configured relevant servers, setup basic frontend and developed a cloud platform with basic authentication and authorization services. After successful implementation of this cloud platform with some other appli- cations, we developed a banking solution named SEPA Secure Banking which is our main research area for banking system. We made our SEPA banking solution operative inside our cloud system to analyze the security risks and concerns a bank can have. We also implemented standard security services as s result of our findings.
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BENJELLOUN, TOUIMI ZINEB. „Caracterisation de sepa, une protease secretee par shigella flexneri“. Paris 7, 1997. http://www.theses.fr/1997PA077093.
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La shigellose est une maladie diarrheique strictement humaine due a l'invasion de l'epithelium intestinal par les bacteries du genre shigella. Cette maladie se caracterise par la destruction de l'epithelium colique due a une inflammation aigue au site d'infection. Les facteurs de virulence de shigella deja identifies sont codes par un plasmide de virulence et sont secretes ; il s'agit des proteines ipaa, b, c et d, requises pour l'entree dans les cellules, et de icsa, implique dans le mouvement intracellulaire de la bacterie. Notre etude a porte sur la caracterisation d'une autre proteine secretee, designee sepa. Le gene codant pour cette proteine a ete localise sur le plasmide de virulence, clone, sequence et inactive. L'attenuation de la destruction tissulaire et de l'inflammation provoquees par le mutant sepa dans le modele d'infection des anses ileales de lapin indique que sepa intervient dans l'expression du pouvoir pathogene de shigella et suggere que sepa puisse etre implique dans l'invasion tissulaire. L'invasion de l'epithelium intestinal par s. Flexneri etant favorisee par la reponse inflammatoire, notamment par le recrutement de polynucleaires neutrophiles au site d'entree, un role pro-inflammatoire de sepa pourrait permettre l'amplification du processus invasif. Sepa est synthetise sous la forme d'un precurseur de 146 kda dont l'extremite n-terminale est impliquee dans le passage de la membrane interne et l'extremite c-terminale dans celui de la membrane externe. La proteine secretee mature de 110 kda presente un motif caracteristique des proteases a serine et possede une activite proteolytique sur des peptides synthetiques. L'absence d'activite proteolytique sur differentes proteines - qui constituent une barriere contre l'invasion de l'epithelium intestinal par la bacterie, participent a la structure de la matrice extracellulaire et a son remodelage, ou prennent part a la reaction inflammatoire - indique que sepa est une protease avec une specificite de substrat tres restreinte. L'analyse structurale de sepa, par comparaison de sequence et proteolyse menagee, met en evidence quatre domaines au sein de la proteine mature et suggere que sepa puisse etre une toxine de type a-b dont le domaine catalytique serait transloque dans le cytoplasme de la cellule cible.
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Ferreira, Aila Soares. „Varia??o temporal e descri??o de novas esp?cies de collembola (arthropoda, hexapoda) em uma ?rea de caatinga do nordeste do Brasil“. Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17353.
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Collembola is one of the most abundant and diverse group of terrestrial arthropods, being at the base of the food chain operating in the decomposition process. They have a wide distribution in the world and can be found in practically all habitats. The knowledge of this distinctive fauna is still deficient in brazilian territory, especially in semi-arid region. The aim of this study was to investigate which climatic variables may act as predictors of species richness, abundance of individuals and compositional structure of the taxocenose of Collembola over 12 months in an area dominated by semi-arid Caatinga vegetation, northeastern Brazil and describe new species of the genus Seira found, more diverse taxon of Collembola in Brazil. Samples were collected in Jo?o C?mara, Rio Grande do Norte. Ten plots of 20 x 20 meters were established and the specimens were collected with collection effort of one hour/people using entomological aspirator. The identification and description of the species was carried out by studying the morphology and chaetotaxy. Was performed a multiple regression analysis between species richness and abundance of individuals with climatic variables. A total of 1231 individuals belonging to 15 species, 12 genera and nine families. The greatest richness and abundance of Collembola were found during the rainy season. The genus Seira was the most abundant. Rainfall explained the temporal variation in species richness and abundance of Collembola in the semi-arid region, which is consistent with the biology of these animals. The populations of Collembola showed grouped distribution. Three new species of Seira were described and illustrated and all show similarities with species already registered in the national territory
Collembola constitui um dos grupos mais abundantes e diversos de artr?podes terrestres, estando na base da cadeia alimentar e atuando no processo de decomposi??o. Possuem ampla distribui??o no mundo e podem ser encontrados em praticamente todos os habitats. O conhecimento desta distinta fauna ainda ? deficiente em territ?rio brasileiro, especialmente no semi?rido. O objetivo desse estudo foi investigar quais as vari?veis clim?ticas podem atuar como preditoras da riqueza de esp?cies, abund?ncia de indiv?duos e da estrutura composicional da taxocenose de Collembola ao longo de 12 meses em uma ?rea semi?rido dominada por vegeta??o de Caatinga, Nordeste brasileiro; e descrever novas esp?cies encontradas do g?nero Seira, t?xon mais diverso de Collembola no Brasil. As coletas foram realizadas em Jo?o C?mara, Rio Grande do Norte. Dez parcelas de 20 x 20 metros foram estabelecidas e os esp?cimes foram coletados com esfor?o de coleta de uma hora por pessoa utilizando um aspirador entomol?gico. A identifica??o e descri??o das esp?cies foram realizadas atrav?s do estudo da morfologia e quetotaxia dos exemplares. Foi realizada uma an?lise de regress?o m?ltipla entre a riqueza de esp?cies e a abund?ncia de indiv?duos com as vari?veis clim?ticas. Foi coletado um total de 1231 indiv?duos, distribu?dos em 15 esp?cies, 12 g?neros e nove fam?lias. As maiores riqueza e abund?ncia de Collembola foram encontradas durante a esta??o chuvosa. O g?nero Seira foi o mais abundante. A precipita??o explicou varia??o temporal da riqueza de esp?cies e abund?ncia de Collembola no semi?rido, o que condiz com a biologia desses animais. As popula??es de Collembola apresentaram distribui??o agrupada. Tr?s esp?cies novas de Seira foram descritas e ilustradas e todas apresentam semelhan?as com esp?cies j? registradas em territ?rio nacional
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Piña, Burgos María Elena. „Análisis jurídico técnico de las vías de evaluación ambiental en Chile (Declaración y estudio de impacto ambiental) y su relación con los principios rectores que las sustentan“. Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/150004.
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Souter, Corioli. „Archaeology of the iron barque Sepia : an investigation of cargo assemblages“. University of Western Australia. Centre for Archaeology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0153.
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The Western Australian Museum houses a large collection of artefacts from late nineteenth century iron sailing vessels, wrecked en route from Britain. The bulk of this collection comprises cargo objects, destined for sale in the Swan River colony. The protection afforded artefacts, due to the integrity of these shipwrecks, presents new research opportunites for identifying particular classes of commodities which were considered either necessary or desirable for colonial consumers. This thesis examines the notion of material consumption as reflected in shipwreck assemblages in Western Australia for the later nineteenth century, prior to Federation. The research is concerned with the notion of cultural continuity from Britain through specific product selection, as demonstrated by the archaeological assemblages of iron barques importing general merchandise into the colony. Focusing on the Sepia (1898), the objectives include an appraisal of shipwreck cargo artefacts and their applicability to questions relating to consumer behaviour. While the primary objective of this study is on the identification of cargo assemblages, it presents an opportunity to study taphonomic processes and provide a method of relating the vessel to its cargo contents in order to answer broader questions about shipping practices, with a particular focus on stowage. This research also critiques shipwreck collections comprised of selectively recovered, unprovenanced artefacts and suggests appropriate methods for using such material.
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Langridge, Keri V. „Defensive coloration and behaviour in juvenile common cuttlefish Sepia officinalis L“. Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441630.
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Culligan, Jay. „A quantitative and qualitative approach to cuttlefish (Sepia officinalis) body patterning“. Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/71107/.
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Cuttlefish are renowned for their ability to quickly alter the colour and texture of their skin, for camouflage and communication. This is due to the presence of thousands of pigment-filled sacs, known as chromatophores, which are distributed across the skin. The chromatophores are innervated by motoneurons, which dilate the chromatophores to create the spots, stripes, and other markings, known as chromatic components. There are 34 recognized chromatic components, and it is an interesting question how cuttlefish coordinate the expression of these components to camouflage and communicate. The digital age has introduced new, powerful algorithms and methods to tease out subtle features in the coloration patterns, by means of image registration, segmentation, and identification, as well as methods for modeling the underlying control systems. These tools offer major new insights into the mechanisms of visual perception. In addition, powerful techniques have recently been developed that have yet to be applied to this complex visual motor control system. These methods have large potential in helping discover what features between the pattern and the environment are necessary to prevent detection. Here I present four laboratory experiments, that for the first time use machine learning models, to investigate cuttlefish pattern formation, implementation, and information. The first two experimental chapters investigate how cuttlefish orchestrate their chromatic components for camouflage patterns, and what strategies they employ on diverse backgrounds. I demonstrate that components are expressed more independently than previously believed, finding that the range of patterns expressed lie on a continuum, allowing us to suggest a revised classification scheme for cuttlefish body patterns. The diversity of patterns seem to imply that a cuttlefish could use its repertoire flexibly to display the maximally cryptic pattern for a given background, however I show that cuttlefish to not in fact select a single (possibly optimal) camouflage pattern, continually alter their appearance on a given background, and that the frequency of change increases in relation to the size of the objects in the environment. My third chapter investigated the language-like properties of cuttlefish communication using human speech recognition models. From our subset of cuttlefish patterns, I discovered cuttlefish utilize a lexicon of 10 patterns, with language-like properties such as: they obeyed Zipf's law, contained around 1.6 bits per display, and interestingly, while 2 patterns were visually similar, they were displayed in separate contexts. By implementing a regression onto the patterns, I introduce a basic dictionary of cuttlefish terms and their meaning. From my investigations into cuttlefish intraspecific signaling, I discovered two previously undocumented patterns, used in agonistic encounters between cuttlefish. My final chapter describes these patterns and the contexts they are displayed.
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ALMEIDA, Carlos Alexandre Barros de. „Transpiração Em Coffea Canephora: Lisimetria, Fluxo de Seiva e Balanço Hídrico“. Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/12325.
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license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)Made available in DSpace on 2015-03-13T12:18:17Z (GMT). No. of bitstreams: 2 TESE Carlos Alexandre Barros de Lima.pdf: 2933765 bytes, checksum: b70f4bb441ca4a5528f604c290019c29 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2012-01-27
O café é um importante produto na agricultura brasileira, ocupa importante posição entre os produtos de exportação, conhecer a transpiração dessa espécie é um fator decisivo na obtenção da alta produtividade. O consumo de água em uma planta de café conilon cultivado em lisímetro foi avaliado. O experimento objetivou estudar a transpiração diária do café e foi realizado no Departamento de Energia Nuclear da UFPE, em Recife – PE, em 2011, por meio de três métodos: a) lisimetria, por análise de variação de massa; b) balanço hídrico, com medidas de umidade do solo realizadas por sensores tipo TDR; e c) fluxo de seiva via método térmico do balanço de calor no caule. Para esse estudo foi realizada a montagem de um lisímetro de pesagem eletrônica, e foram realizadas as calibrações de todos os sensores envolvidos, sendo obtidos importantes resultados dessas. A demanda atmosférica foi determinada com dados obtidos em duas estações meteorológicas, uma situada próximo ao lisímetro, e a outra, distante cerca de um quilômetro, situada no pátio externo do CRCN. Também foi determinado o índice de área foliar (IAF) do cafeeiro. A área foliar variou de 1,39 a 1,87 m2 durante o experimento. O consumo de água medido através do lisímetro variou de 2,61 L a 5,16 L por dia, com média de 3,86 L por dia. Ao comparar-se o consumo de água na planta pelo balanço hídrico verificou-se uma subestimação em alguns dias e superestimação em outros dias de 10% com os resultados obtidos no lisímetro. A transpiração medida pelo fluxo de seiva via método térmico subestimou em 10% as medidas realizadas no lisímetro. Os resultados do estudo indicaram grande precisão na estimativa da transpiração do café conilon.