Auswahl der wissenschaftlichen Literatur zum Thema „Schémas de fractionnement de radiothérapie“
Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an
Inhaltsverzeichnis
Machen Sie sich mit den Listen der aktuellen Artikel, Bücher, Dissertationen, Berichten und anderer wissenschaftlichen Quellen zum Thema "Schémas de fractionnement de radiothérapie" bekannt.
Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.
Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.
Zeitschriftenartikel zum Thema "Schémas de fractionnement de radiothérapie"
Bourgier, C., C. Lemanski, R. Draghici, F. Castan, P. Fenoglietto, F. Bons, M. P. Farcy-Jacquet et al. „Personnalisation de la dose, du volume et du fractionnement de la radiothérapie du sein“. Cancer/Radiothérapie 23, Nr. 6-7 (Oktober 2019): 778–83. http://dx.doi.org/10.1016/j.canrad.2019.06.004.
Der volle Inhalt der QuellePy, J. F., J. Salleron, G. Vogin, F. Courrech, F. Baumard, D. Peiffert, G. Oldrini und J. C. Faivre. „Évaluation de la radiothérapie stéréotaxique seule ou associée à une radiothérapie conformationnelle de fractionnement standard dans le traitement des oligométastases osseuses“. Cancer/Radiothérapie 22, Nr. 6-7 (Oktober 2018): 729. http://dx.doi.org/10.1016/j.canrad.2018.07.094.
Der volle Inhalt der QuelleMontpetit, Crystele, und Savitri Singh-Carlson. „Encourager les autosoins chez les patientes souffrant de réactions cutanées dues à la radiothérapie“. Canadian Oncology Nursing Journal 28, Nr. 3 (2018): 201–11. http://dx.doi.org/10.5737/23688076283201211.
Der volle Inhalt der QuelleGabelle-Flandin, I., V. Beneyton, A. Dusserre, R. Sihanath, C. de Villèle, I. Henry, S. Vassal, A. Tessier, J. Balosso und J. Y. Giraud. „Étude pilote de « boost intégré » avec fractionnement en quatre séances hebdomadaires dans la radiothérapie du sein“. Cancer/Radiothérapie 15, Nr. 6-7 (Oktober 2011): 575. http://dx.doi.org/10.1016/j.canrad.2011.07.041.
Der volle Inhalt der QuelleCoraggio, G., G. Loganadane, S. Husheng, S. Ghith, N. Grellier, M. L. Hervé, N. H. To et al. „Radiothérapie hémostatique dans le cancer de la vessie chez les patients inopérables : quel impact du fractionnement ?“ Cancer/Radiothérapie 22, Nr. 6-7 (Oktober 2018): 721. http://dx.doi.org/10.1016/j.canrad.2018.07.075.
Der volle Inhalt der QuelleMirjolet, C., M. Grapin, C. Richard, E. Limagne, R. Boidot, V. Morgand, F. Ghiringhelli und G. Créhange. „Efficacité de l’association de radiothérapie avec des anti-PD-L1 et anti-TIGIT : une question de fractionnement !“ Cancer/Radiothérapie 23, Nr. 6-7 (Oktober 2019): 796. http://dx.doi.org/10.1016/j.canrad.2019.07.020.
Der volle Inhalt der QuelleBlanchard, P., J. Biau, J. Castelli, Y. Tao, P. Graff und F. Nguyen. „Personnalisation de la dose et du fractionnement de la radiothérapie des cancers de la tête et du cou“. Cancer/Radiothérapie 23, Nr. 6-7 (Oktober 2019): 784–88. http://dx.doi.org/10.1016/j.canrad.2019.07.131.
Der volle Inhalt der QuelleVANDELAC, Louise. „Sexes et technologies de procréation : « mères porteuses » ou la maternité déportée par la langue . . .“ Sociologie et sociétés 19, Nr. 1 (30.09.2002): 97–116. http://dx.doi.org/10.7202/001818ar.
Der volle Inhalt der QuelleGuillerme, F., J. E. Kurtz, J. B. Clavier, S. Guihard, C. Schumacher, H. Nehme-Schuster, M. Ben Abdelghani, C. Brigand und G. Noël. „Comparaison de deux schémas de radiothérapie, classique et hypofractionné, chez les patients âgés atteints d’un cancer du rectum localement évolué“. Cancer/Radiothérapie 15, Nr. 6-7 (Oktober 2011): 601. http://dx.doi.org/10.1016/j.canrad.2011.07.116.
Der volle Inhalt der QuelleDieng, MM, NF Kane Ba, N. Ben Amor, EHA Baldé, A. Dem, PM Gaye und L. Kochbati. „C116: Toxicité cutanée tardive après radiothérapie hypo-fractionnée des cancers du sein post-mastectomie : A propos de 40 cas“. African Journal of Oncology 2, Nr. 1 Supplement (01.03.2022): S48. http://dx.doi.org/10.54266/ajo.2.1s.c116.veof2707.
Der volle Inhalt der QuelleDissertationen zum Thema "Schémas de fractionnement de radiothérapie"
Hami, Abdoul-Azize Rihab. „Simulation des processus radiobiologiques basés sur l'imagerie pour l'évaluation de schémas thérapeutiques individualisés en radiothérapie“. Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0002.
Der volle Inhalt der QuelleRadiotherapy is one of the principal cancer treatments. Despite its intensive use in clinical practice, itseffectiveness depends on several factors. Several studies showed that the tumor response to radiotherapy differ from one patient to another. The response of tumor is influenced by several factors like hypoxia and multiple interactions between the tumor microenvironment and healthy cells. Five major biologic concepts called “5 Rs” resume these interactions. These concepts include reoxygenation, DNA damage-repair, cell cycle redistribution, cellular radiosensitivity and cellular repopulation.The optimal treatment strategy must consider these “5 Rs". In this study, we proposed as a first an approach to oxygenation modeling that can be considered as an optimization process in the absence of data concerning oxygen. We used a multi-scale model to predict the effects of radiotherapy on tumor growth based on information extracted from positron-emission tomography (PET) images. Then, we included to our model the ‘’5 Rs’’ of radiotherapy, to predict the effects of radiation on tumor growth. Finally, we presented a study of the effect of different types of fractionations on tumor response to radiotherapy
Clement-Colmou, Karen. „Impact du fractionnement de la radiothérapie sur le microenvironnement vasculaire tumoral“. Thesis, Nantes, 2018. http://www.theses.fr/2018NANT1029/document.
Der volle Inhalt der QuelleThe tumour blood vessels are immature and dysfunctional, limiting the distribution and efficacy of anticancer drugs. Conventional radiotherapy (2Gy / day) improves their structure, reduces hypoxia and improves the biodistribution of concomitant treatments. However, hypofractionated radiotherapy, using higher doses per fraction, tends to replace conventional schedules. Their consequences on the tumour microenvironment are poorly understood. Our goal was to define the impact of different fractionation schedules on the tumour vascular microenvironment. A fractionation scale, ranging from 2 to 12Gy per fraction, was implemented on two cancer models (prostate and lung). Several phenotypical and functional aspects of the vasculature and anti-tumour efficacy were studied. A radiation-induced vascular maturation was observed, including an increased pericyte coverage and an improved distribution of doxorubicin. In both models, tumour control was better for hypofractionated schedules. Vascular pseudo-normalization was poorly sensitive to fractionation, but hypoxia was improved in a dose-dependent manner. The depth and duration of the improvement was greater in the slow-growing prostate cancer model: hypoxia seemed to depend as much on the kinetics of repopulation of the model as on the quality of the blood supply. Our results highlight the mutual influence of tumour and vascular responses to irradiation. They will be useful to optimize the future delivery schedule of anticancer treatments
Labussière, Marianne. „Impact du fractionnement du traitement sur les propriétés radiosensibilisantes du bortézomib sur deux modèles de gliome malin humain xénogreffés“. Thesis, Nancy 1, 2008. http://www.theses.fr/2008NAN10132/document.
Der volle Inhalt der QuelleMalignant gliomas are the most common neoplasm of the central nervous system and patients prognosis remains dismal, despite aggressive surgery, radio- and chemotherapy. Radiotherapy is a major treatment modality in this tumoral type but its usefulness is limited by normal brain tissue toxicity. The concomitant administration of a radiosensitizing agent is an innovative strategy to improve ionizing radiations efficacy. Bortezomib (Velcade®) belongs to a new class of anticancer agents, i.e. the proteasome inhibitors, and this molecule has been approved for the treatment of multiple myeloma. Our objectives are to study the radiosensitizing properties of bortezomib on two human malignant glioma models xenografted onto nude mice. Our work was designed to evaluate the impact of treatment fractionation on the antitumor activity of the concomitant association of bortezomib and radiotherapy. Our results show that bortezomib is a potent radiosensitizer on our two malignant glioma models but these properties are lost when treatments are fractionated according to a typical clinical schedule. In conditions of fractionated treatment, we demonstrate that bortezomib reduces the radio-induced apoptosis. This may be linked to the loss of the inhibitory properties of bortezomib secondary to consecutive infusions. We also evaluate the importance of the transcription factor NF-?B in the radioresponse of the malignant glioma xenografts used. Finally, our work emphasizes on the importance of performing preclinical studies using doses and therapeutic schedule mimicking the clinical settings to provide more predictive results of treatment response in Humans
Peucelle, Cécile. „Spatial fractionation of the dose in charged particle therapy“. Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS363/document.
Der volle Inhalt der QuelleDespite recent breakthroughs, radiotherapy (RT) treatments remain unsatisfactory : the tolerance of normal tissues to radiations still limits the possibility of delivering high (potentially curative) doses in the tumour. To overcome these difficulties, new RT approaches using distinct dose delivery methods are being explored. Among them, the synchrotron minibeam radiation therapy (MBRT) technique has been shown to lead to a remarkable normal tissue resistance to very high doses, and a significant tumour growth delay. MBRT allies sub-millimetric beams to a spatial fractionation of the dose. The combination of the more selective energy deposition of charged particles (and their biological selectivity) to the well-established normal tissue sparing of MBRT could lead to a further gain in normal tissue sparing. This innovative strategy was explored in this Ph.D. thesis. In particular, two new avenues were studied: proton MBRT (pMBRT) and very heavy ion MBRT. First, the experimental proof of concept of pMBRT was performed at a clinical facility (Institut Curie, Orsay, France). In addition, pMBRT setup and minibeam generation were optimised by means of Monte Carlo (MC) simulations. In the second part of this work, a potential renewed use of very heavy ions (neon and heavier) for therapy was evaluated in a MC study. Combining such ions to a spatial fractionation could allow profiting from their high efficiency in the treatment of hypoxic radioresistant tumours, one of the main challenges in RT, while reducing at maximum their side effects. The promising results obtained in this thesis support further explorations of these two novel avenues. The dosimetry knowledge acquired will serve to guide the biological experiments
Schneider, Tim. „Advancing the generation of proton minibeams for radiation therapy“. Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASP069.
Der volle Inhalt der QuelleDespite major advances over the last decades, the dose tolerance of normal tissue continues to be a central problem in radiation therapy, limiting for example the effective treatment of hypoxic tumours and high-grade gliomas. Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy, combining the improved ballistics of protons with the enhanced tissue sparing potential of submillimetric, spatially fractionated beams (minibeams), that has already demonstrated its ability to significantly improve the therapeutic index for brain cancers in rats. In contrast to conventional proton therapy which uses comparatively large beam diameters of five millimetres to several centimetres, minibeams require beam sizes of less than 1 mm which are challenging to create in a clinical context. So far, every implementation of pMBRT at clinically relevant beam energies could only be achieved with the help of mechanical collimators (metal blocks with thin slits or holes). However, this method is inefficient, inflexible and creates high levels of unwanted secondary particles. The optimal approach may therefore be the generation of minibeams through magnetic focussing.This thesis investigates how magnetically focussed proton minibeams can be realised in a clinical context. Starting from the computer model of a modern pencil beam scanning nozzle (the term "nozzle" describes the final elements of a clinical beamline), it could be shown that current nozzles will not be suitable for this task, since their large dimensions and the presence of too much air in the beam path make it impossible to focus the beam down to the required sizes. Instead, an optimised nozzle design has been developed and evaluated with clinical beam models. It could be demonstrated that this design allows the generation of proton minibeams through magnetic focussing and that the new nozzle can be used with already existing technology. Moreover, a Monte Carlo study was performed to compare and quantify the differences between magnetically focussed minibeams and mechanically collimated minibeams.Finally, as the second aspect of this thesis, helium ions were evaluated as a potential alternative to protons for minibeam radiation therapy. It could be shown that helium ions could present a good compromise exhibiting many of the dosimetric advantages of heavier ions without the risks related to normal tissue toxicities
Sarazin, Desbois Céline. „Méthodes numériques pour des systèmes hyperboliques avec terme source provenant de physiques complexes autour du rayonnement“. Phd thesis, Université de Nantes, 2013. http://tel.archives-ouvertes.fr/tel-00814182.
Der volle Inhalt der Quelle