Thematische Bibliographien / S HPMA copolymers

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Auswahl der wissenschaftlichen Literatur zum Thema „S HPMA copolymers“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 17. Februar 2022

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Zeitschriftenartikel zum Thema "S HPMA copolymers"

Fan, Wei, Wenting Zhang, Yinnong Jia, Susan K. Brusnahan und Jered C. Garrison. „Investigation into the Biological Impact of Block Size on Cathepsin S-Degradable HPMA Copolymers“. Molecular Pharmaceutics 14, Nr. 5 (21.03.2017): 1405–17. http://dx.doi.org/10.1021/acs.molpharmaceut.6b01038.

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Fan, Wei, Wen Shi, Wenting Zhang, Yinnong Jia, Zhengyuan Zhou, Susan K. Brusnahan und Jered C. Garrison. „Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer“. Biomaterials 103 (Oktober 2016): 101–15. http://dx.doi.org/10.1016/j.biomaterials.2016.05.036.

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Shi, Wen, Sunny M. Ogbomo, Nilesh K. Wagh, Zhengyuan Zhou, Yinnong Jia, Susan K. Brusnahan und Jered C. Garrison. „The influence of linker length on the properties of cathepsin S cleavable 177Lu-labeled HPMA copolymers for pancreatic cancer imaging“. Biomaterials 35, Nr. 22 (Juli 2014): 5760–70. http://dx.doi.org/10.1016/j.biomaterials.2014.03.056.

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York, Adam W., Faqing Huang und Charles L. McCormick. „Rational Design of Targeted Cancer Therapeutics through the Multiconjugation of Folate and Cleavable siRNA to RAFT-Synthesized (HPMA-s-APMA) Copolymers†“. Biomacromolecules 11, Nr. 2 (08.02.2010): 505–14. http://dx.doi.org/10.1021/bm901249n.

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Ogbomo, Sunny M., Wen Shi, Nilesh K. Wagh, Zhengyuan Zhou, Susan K. Brusnahan und Jered C. Garrison. „177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: Synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model“. Nuclear Medicine and Biology 40, Nr. 5 (Juli 2013): 606–17. http://dx.doi.org/10.1016/j.nucmedbio.2013.01.011.

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Mirajkar, Reshma N., Kalyani Pruthviraj Dhavale und Ashwini R. Madgulkar. „FORMULATION DEVELOPMENT OF SUSTAINED RELEASE EPIDURAL INJECTION OF ANALGESIC DRUG“. Journal of Drug Delivery and Therapeutics 9, Nr. 4-s (18.08.2019): 540–46. http://dx.doi.org/10.22270/jddt.v9i4-s.3292.

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The objective of this work was to formulate and evaluate sustained release epidural injection of analgesic drug diclofenac sodium used in chronic lower back pain. The formulation composed of a thermosensitive polymer Pluronic F127 (20%) and sustained release copolymers HPMC K100M (1%) and HPMC K4M (0.5%) optimized using 32 factorial design. The formulation was found to be clear, colorless, sterile, syringeable through 18gauge, forming a stable gel at 37°C with a gel strength of 9.67g/cm. The drug release was found to be 98.13% in 72 hrs. The formulation was found to be stable at refrigerator temperature of 5°C for a month. Thus, a stable parenteral formulation was developed that can be an appropriate and convenient approach for patients requiring frequent parenteral administration, reducing recurrence of dosage and ultimately expanding patient comfort and satisfaction in case of chronic ailments.

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Lai, Nanjun, Xiaoping Qin, Zhongbin Ye, Qin Peng, Yan Zhang und Zheng Ming. „Synthesis and Evaluation of a Water-Soluble Hyperbranched Polymer as Enhanced Oil Recovery Chemical“. Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/824785.

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A novel hyperbranched polymer was synthesized using acrylamide (AM), acrylic acid (AA),N-vinyl-2-pyrrolidone (NVP), and dendrite functional monomer as raw materials by redox initiation system in an aqueous medium. The hyperbranched polymer was characterized by infrared (IR) spectroscopy,1H NMR spectroscopy,13C NMR spectroscopy, elemental analysis, and scanning electron microscope (SEM). The viscosity retention rate of the hyperbranched polymer was 22.89% higher than that of the AM/AA copolymer (HPAM) at 95°C, and the viscosity retention rate was 8.17%, 12.49%, and 13.68% higher than that of HPAM in 18000 mg/L NaCl, 1800 mg/L CaCl2, and 1800 mg/L MgCl2·6H2O brine, respectively. The hyperbranched polymer exhibited higher apparent viscosity (25.2 mPa·s versus 8.1 mPa·s) under 500 s−1shear rate at 80°C. Furthermore, the enhanced oil recovery (EOR) of 1500 mg/L hyperbranched polymer solutions was up to 23.51% by the core flooding test at 80°C.

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Quintero Perez, Henderson Ivan, Miguel José Rondon Anton, Jaime Alberto Jimenez, John Hervin Bermudez, Julian Alfredo Gonzalez, Jenny Liset Rodrigues und Carlos Espinosa Leon. „Polymeric surfactants as alternative to improve waterflooding oil recovery efficiency“. CT&F - Ciencia, Tecnología y Futuro 10, Nr. 2 (17.12.2020): 99–113. http://dx.doi.org/10.29047/01225383.272.

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Chemical formulations, including surfactants, polymers, alkalis, or their combinations, are widely used in different oil recovery processes to improve water injection performance. However, based on challenging profit margins in most mature waterfloods in Colombia and overseas, it is necessary to explore alternatives that could offer better performance and greater operational flexibility than the conventional technologies used for enhanced oil recovery (EOR) processes. Polymeric surfactants are compounds widely used in the manufacture of domestic and industrial cleaning, pharmaceutical, cosmetic, and food products. These compounds represent an interesting alternative as they can simultaneously increase the viscosity in water solution and reduce the interfacial tension (IFT) in the water/oil system, which would increase the efficiency of EOR processes. This article shows a methodological evaluation through laboratory studies, numerical reservoir simulation, and conceptual engineering design to apply polymeric surfactants (Block Copolymer Polymeric Surfactants or BCPS) as additives to improve efficiency in water injection processes. Block copolymer type products of ethylene oxide (EO) - propylene oxide (PO) - ethylene oxide (EO) in aqueous solution were studied to determine their rheological and surfactant behavior under the operating conditions of a Colombian field. In the conditions studied, these products allow to reduce the interfacial tension up to 2x10-1 mN/m values and also cause a shear-thinning rheological behavior following the power law at very low shear rates (0.1 s-1– 1 s-1), which corresponds to an increase up to four orders of magnitude in the capillary number (Nc). The IFT and the viscosity reached are maintained in wide ranges of salinity, BCPS concentration, and shear rates, making it a robust performance formulation. In a model porous medium, BCPS tested have moderate adsorption, less than conventional surfactants but higher than HPAM polymers, in any way allowing a favorable wettability condition. Additionally, it was observed that they offer a resistance factor up to 16 times, causing greater displacement efficiency than water injection, allowing better sweeping in low permeability areas without injectivity restrictions. Numerical simulation shows that it is possible to reach incremental production up to 238,5 TBO by injecting a continuous slug of 0.15 pore volumes of BCPS and HPAM, each with 2,000 ppm concentration and a flow rate of 2,500 BPD. As BCPS are simple handling and dilution products, these could be injected directly in water injection flow using a high precision dosing pump with high pressure and flow rate operational variables.

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Dissertationen zum Thema "S HPMA copolymers"

Hrabánková, Klára. „Využití polymerních proléčiv s cucurbitacinem D pro léčbu experimentálních nádorů“. Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446100.

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Chemotherapy is still the most widely used anti-cancer treatment. The majority of chemotherapeutics inhibit proliferating cells generally, not selectively cancer cells. The side effects associated with chemotherapy can be partly limited by conjugating a cytotoxic drug with a polymer nanocarrier. Such binding facilitates solubility in aqueous solutions, reduces systemic toxicity; and passively targets the drug directly into the tumour through the enhanced permeability and retention (EPR) effect. This thesis focuses on testing polymer conjugates based on N-(2-hydroxypropyl)methacrylamide (HPMA) carrying cucurbitacin D (CuD), a naturally occurring compound with potential anti-cancer activity. The mechanism of action is not elucidated yet, but several studies have depicted the inhibitory effect on signal transducer and activator of transcription 3 (STAT3) transcription factor. A STAT3 signalling pathway is overexpressed in several cancer cell lines and is also involved in the differentiation of myeloid- derived suppressor cells (MDSCs). We examined the therapeutic effect of the HPMA copolymers based on CuD in combined therapy with other polymer chemotherapeutics. CuD conjugates have shown in vitro cytotoxic effect on several model cancer cell lines. The combination with conjugates carrying doxorubicin...

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Černý, Viktor. „Užití biodegradabilních polymerních konjugátů s vysokou molekulovou hmotností k účinnému/ doručení cytostatických léčiv do solidních nádorů“. Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-353801.

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Cancer remains one of the most pressing issues of contemporary science and medicine. Incidence of malignant diseases is rising worldwide and they represent a major problem for the society due to both economic and ethical issues they cause. Although the progress in cancer biology, therapy and immunology has led to the introduction of many novel therapeutic protocols, approaches and drugs with specificity defined on a molecular level into clinical practice, many malignancies retain their poor prognosis. Therefore, intense research into new ways to increase our therapeutic options is warranted. Unfortunately, bringing a completely novel drug into clinical use takes extremely high amounts of time and money and entails a high risk of failure. Therefore, a promising approach has been recently adopted which lies in repurposing compounds already used in human medicine for cancer treatment. This form of research can advance through clinical trials for a new indication much easier, faster and cheaper than researching completely new drugs. The aim of this study was to examine the anticancer potential of one such drug, mebendazole. An anthelminthic from the family of benzimidazoles, mebendazole has been in common clinical use from the 1970s and is marked by its low toxicity as well as its very low solubility....

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