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Wood, Evan Alexander. „Designing hypercyclic replicating networks /“. St Andrews, 2007. http://hdl.handle.net/10023/360.
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Wood, Evan A. „Designing hypercyclic replicating networks“. Thesis, University of St Andrews, 2007. http://hdl.handle.net/10023/360.
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In the last 20 years there has been a number of synthetic and natural product based molecular replicators published in the literature. The majority of these systems have focused on the minimal model with only a few examples of cross-catalytic or reciprocal replication. Of the cross-catalytic systems investigated the majority focus around the use of natural products, oligonucleotides, peptides etc. This thesis will investigate the design, synthesis and kinetic analysis of both synthetic minimal and reciprocal replicating systems, and how these two forms of replication interact in a complex hypercyclic network. Chapter 1 introduces key concepts such as molecular recognition, intramolecularity/ enzyme kinetic, bisubstrate systems and the work conducted into replication systems to date. Chapter 2 describes the design, synthesis and kinetic analysis of a reciprocal replicating system, based on Diels-Alder and 1,3-dipolar cycloadditions, before going on to discuss what we have learned and how this system can be improved. Chapter 3 focuses on the design, synthesis and kinetic analysis of a replicating network (minimal and reciprocal replication), based on 1,3-dipolar cycloadditions. Initial individual systems are examined in isolation to determine their behavior and nature. After which the systems are combined to observe how each species interacts in a potential complex hypercyclic network. Chapter 4 investigates the redesign of the replicating network in Chapter 3 in order to overcome the problems identified from its kinetic analysis. Chapter 5 introduces the shift in direction away from kinetically controlled replicating networks towards systems in thermodynamic equilibrium.
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Bengtsson, Marie. „The art of replicating /“. Linköping : Department of Management and Engineering, Linköping University, 2008. http://www.bibl.liu.se/liupubl/disp/disp2008/arts462s.pdf.
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Uhlig, Tobias [Verfasser]. „Self-Replicating Individuals / Tobias Uhlig“. München : Verlag Dr. Hut, 2015. http://d-nb.info/1077404018/34.
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Prywes, Noam. „Towards Self-Replicating Informational Polymers“. Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493609.
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The capability to transmit information from generation to generation is an essential feature of life. In all terrestrial life, DNA and RNA contain information in the form of a sequence of monomers and are copied in every generation. The RNA world hypothesis posits that there was a time in the history of life when all cellular functions were accomplished by RNA catalysts. However, the initial emergence of those RNA catalysts is not yet fully understood.
Nonenzymatic RNA polymerization has been proposed as a potential stepping- stone from prebiotic chemistry to the RNA world. In searching for alternatives to the chemically trapped triphosphate nucleotides found in modern biology, chemical modifications of RNA have been discovered that allow for the copying of RNA. However, the copying of sequences rich in adenine and uracil residues remains a significant challenge. In chapter 2 we use chemically activated oligonucleotides as catalysts to copy all four monomers sequentially, potentially creating a route for the copying of any sequence without a polymerase and contributing to a model for the emergence of evolution.
Replacing uracil with 2-thiouracil and 2-thiothymine, modified forms of uracil found in modern life, has proven to improve the reactivity and fidelity of nonenzymatic RNA polymerization. In chapter 3, we tested these alternatives to uracil as substrates and components of an RNA polymerase ribozyme. We discovered that they were superior in the context of ribozyme mediated RNA polymerization both in terms of faster rate and higher fidelity. We then synthesized ribozymes in which every instance of uracil was replaced by either 2-thiouracil or 2-thiothymine and found them to retain some activity. We hypothesize that these alternative nucleobases could have conferred significant benefits to early life forms.
To explore alternative genetic systems to DNA and RNA, in chapter 4 of this thesis we synthesized an organic-soluble copolymer with two different monomers capable of reversible covalent bond formation with one another. We show that information copying is possible with this polymer by synthesizing a polymer with a sequence complementary to a template while it is still covalently bound to that template, demonstrating that nucleic acids are not the only molecules capable of information storage and replication.
Together, these results assist in the construction of artificial life and expand the possibilities for the emergence of life.Chemistry and Chemical Biology
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Najmabadi, Hossein. „Characterization of the Self-Replicating Kirsten Murine Leukemia Viral DNA: Replication and Tetracycline Resistance“. Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798479/.
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This research project deals with the characterization of self-replicating Kirsten murine viral DNA. The replication of this viral DNA and tetracycline resistance conferred to bacteria by this viral DNA will be studied. The restriction endonuclease and Southern blot analysis revealed a fragment of pBR322 from the Hind III and Pst I site that is located in the 3' end of the MLV-K:E molecule. Single stranded sequencing of the two terminal ends of this fragment verified that the 3' end of MLV-K:E contains identical sequence homology to pBR322. The presence of this pBR322 fragment explains the unusual properties of the MLV-K:E molecule. However, tetracycline resistance is less in E. Coli containing MLV-K:E than E. coli containing pBR322 as determined by zone of inhibition assay. This may be due to alteration in the promoter region of the tetracycline gene.
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Wu, Cunle. „cDNA clones contain autonomously replicating sequences“. Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41041.
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We have shown that nine cDNA clones, which were derived from an oligo (dT) primed cDNA library of human embryonic lung fibroblast (IMR90), are capable of supporting autonomous replication of bacterial plasmid in mammalian (HeLa) cells. Two of these cDNA clones contain a region homologous to "O"-family middle repetitive sequences; the other seven clone hybridize with neither "O"-family nor Alu family sequences and are called NOA clones. Oligo (dT) primed cDNA of IMR90 has been demonstrated to be an enriched source for autonomously replicating sequences. Two out of three "O"-family homologous cDNA clones and seven out of ten NOA clones were capable of autonomous replication. In contrast, none of the five clones, which contained Alu repetitive sequences, demonstrated replicative potential. The two autonomously replicating, "O"-family homologous cDNA, 343 and 363, were characterized in the greatest detail. In particular, sequence and structural features of a 448 bp fragment of cDNA 343, which was capable of supporting autonomous replication activity, were: extensive asymmetrical A/T-rich regions; 10/11 match to yeast ARS consensus; scaffold attachment region consensus of Drosophila; bent DNA; a DNA unwinding element and an in vitro matrix binding activity. We have used a PCR-based mapping strategy to identify an in vivo initiation zone located in a region of approximately 1.6 kb which is inclusive of cDNA 343. The 343 sequence has been localized to the long arm (6q22-6qter) of human chromosome 6 by both Southern analysis of hamster-human cell hybrids and in situ hybridization. Transcripts homologous to 343 have been detected in both poly(A$ sp+$) and non-poly(A$ sp+$) RNA fractions to be 1.3 kb and 5 kb, respectively; the 1.3 kb transcript is greatly enriched in poly(A$ sp+$) RNA fraction, and the 5 kb transcript is present predominantly in non-poly(A$ sp+$) RNA fraction. The detailed characterization of 343 genomic locus demonstrated that the 343 sequence is conserv
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Penzes, Zoltan. „Defective replicating RNAs of coronavirus infectious bronchitis virus : investigation of replication and genome packaging signals“. Thesis, University of Hertfordshire, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283879.
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Nguyen, Rémi. „Dynamic combinatorial mesophases and self-replicating systems“. Strasbourg, 2010. http://www.theses.fr/2010STRA6285.
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Mon travail de thèse a consisté à développer des systèmes de blocs amphiphiles combinatoires dynamiques pour étudier de possibles phénomènes d’auto-organisation hiérarchique dans l’espace et dans le temps. Pour cela, j’ai combiné des associations réversibles de blocs hydrophiles et hydrophobes en étudiant deux types possibles de contrôle : a) un contrôle moléculaire externe sur les liaisons entre blocs de manière à forcer l’expression d’une mésophase particulière ; et b) un contrôle supramoléculaire interne dicté par la formation préférentielle d’une mésophase, avec sélection spontanée des blocs qui la composent. Lors de ce travail, j’ai pu démontrer pour la première fois la possibilité d’étendre la chimie combinatoire dynamique aux systèmes à micro-séparation de phase. Pour y parvenir, j’ai développé un nouveau type d’objets dynamiques (Dynablocks) et j’ai pu mettre en évidence des comportements très originaux de ces derniers qu’ils soient d’ordre cinétique (auto-réplication) ou thermodynamique (sélection au sein de mélange) ; j’ai également montré que ces deux aspects pouvaient être réunis au sein de processus d’auto-organisation. Pour caractériser les mélanges, de nouvelles méthodes de combinaisons linéaires pour l’analyse des diffusions du rayonnement ont été développées. Cette étude fondamentale constitue une nouvelle ouverture de la chimie combinatoire dynamique aux frontières avec deux domaines d’importance : a) la science des matériaux et b) la chimie des systèmes – en particulier des systèmes autonomes minimaux (i. E. Autopoiétiques)My PhD work consisted in developing combinatorial dynamic systems of amphiphilic block copolymers to study their hierarchical self-organization processes in space and time. For this I combined reversible associations between hydrophobic and hydrophilic blocks, focusing on two possible kinds of control of these responsive systems: a) an external molecular control on the reversible covalent bonds between the blocks in order to favour the expression of a particular mesophase; and b) an internal supramolecular control driven by the preferential formation of a mesophase leading to spontaneous selection of its own composing blocks. During this work, I demonstrated for the first time the possibility to extend dynamic combinatorial chemistry to systems with phase micro-separation. For this, I developed a new type of dynamic molecules (Dynablocks) and I discovered some interesting behaviours from the mesophases I obtained, such as self-replication on a kinetic point of view, or selection/adaptation process within a mixture on a thermodynamic point of view. I also demonstrated that these to aspects could be coupled together in an auto-organization process. To characterize those complex mixtures, new analytical methods were developed for scattering techniques, based on linear combinations. This fundamental study opens a new field of investigation for dynamic combinatorial chemistry in relations with two important domains: a) material science and b) system chemistry – particularly minimal autonomous systems (i. E. Autopoietics systems)
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Myers, Shere Lynne. „Cellular Effects of Replicating a Polypurine-Polypyrimidine Sequence and the Interactions of DUE-B with Replication Proteins“. Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1292507800.
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Pan, Zhijian. „Artificial evolution of arbitrary self-replicating cellular automata“. College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7404.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.Thesis research directed by: Computer Science. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Quick, Molly. „Replicating Predictors of Spirituality and Happiness in Children“. Thesis, Seattle Pacific University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3581561.
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Positive psychology provides the theoretical framework for this replication and extension study of Holder, Coleman, and Wallace (2010). Their results indicated that spirituality (especially the domains of communal and personal) predicted students' (N = 307) happiness (across three dependent measures), even after controlling for temperament (Faces Scale (communal, r = .45, personal, r = .44; p < .05), Oxford Happiness Questionnaire-Short Form (communal, r = .44, personal, r = .48; p < .05), and the Subjective Happiness Scale (communal, r = .34, personal, r = .38; p < .05). The present study used archival data drawn from students in grades 4 through 6 (approximately 8 to 12 years old) attending private (faith-based) schools in Western Washington. Similar to the Holder et al. results, this study revealed positive correlations between spirituality and happiness, even after controlling for gender, grade level, and temperament. Extending the work of Holder et al., participant grade level was included in the regression model in order to account for developmental differences among children, but grade level did not contribute significantly to the overall prediction of students' happiness levels. Gender was also of little predicative value. Implications for theory, research, and practice are included.
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Brunqvist, Oskar. „Modeling Non-Maturing Deposits Using Replicating Portfolio Models“. Thesis, KTH, Optimeringslära och systemteori, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-228217.
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In recent years, regulatory and legislative authorities have increased their interest in non-maturing products, more specifically modeling of non-maturing deposits. This increase stems from the ever growing portion of banks funding originating from these products. The main purpose of this thesis is to provide an overview of different replicating portfolio models available for modeling non-maturing deposits and as-sess their applicability and suitability. Six different models suggested in the literature and two model extensions are presented and evaluated based on three categories; goodness of fit, stability and transparency. The results indicate that static replicating portfolios provide a poor fit for modeling the interest rate behavior in current interest rate market conditions.Tillsynsmyndigheter och lagstiftande organ har under senare år ökat sitt intresse i finansiella produkter som saknar kontrakterad förfallodag, framförallt icke tidsbunden inlåning. Detta beror på att bankers finansiering i allt större utsträckning utgörs av dessa instrument. Det huvudsakliga syftet med detta arbete är att skapa en översiktlig bild av befintliga modeller som använder replikerande portföljer och utvärdera deras lämplighet. Sex olika modeller från befintlig litteratur samt två nya modeller presenteras och utvärderas baserat på tre kategorier; passform, stabilitet och transparens. Resultaten indikerar att statiska replikerande portföljer överlag har en dålig passform för att modellera räntesättningsbeteende i rådande marknadsränteläge.
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Ask, Alexandra. „REPLICATING THE TUMOUR MICROENVIRONMENT:CHEMOSENSITIVITY TESTING IN FIBROBLAST COCULTURES“. Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327344.
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Roberts, Jacqueline Lucy. „A study of replicating instabilities in Schizosaccharomyces pombe“. Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/14296.
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Homicsko, Krisztian Gyula. „Capsid modified replicating adenovirus to selectively target colon cancer“. [S.l.] : [s.n.], 2006. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:ch:bel-101121.
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Shan, Jonathan (Jonathan W. ). „Replicating the carry trade through an exchange traded fund“. Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/80680.
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Thesis (S.M.)--Massachusetts Institute of Technology, Sloan School of Management, 2013.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 45-49).
There is an overarching belief that the carry trade is a simple investment strategy based on the popular mantra of buying low and selling high. However, in reality, there are several factors that need to be taken into consideration when devising a carry trade strategy. These hardships are further complicated by the number of options available in such a strategy. The main objective of my thesis is to implement this popular hedge fund strategy through the structure of an exchange traded fund. The interest rate spread between two different currencies should be an expectation of future exchange rates, however, empirically, this belief does not hold true. The carry trade takes advantage of this violation of uncovered interest rate parity and I will show that a specific implementation of the carry trade yielded positive returns on a historical basis. I believe it is essential to understand the basics of the carry trade. I will discuss the mechanics and highlight the inherent advantages and risk factors in making such an investment. I will then discuss the current landscape and what financial products are available to investors who want to take advantage of the carry trade - from hedge funds to exchange traded notes and exchange traded funds. Next, I will discuss how one goes about launching an exchange traded fund and the various considerations that need to be made by someone undertaking such an endeavor. Finally, I will try and establish demand for a carry trade exchange traded fund in the retirement market and investigate the hurdles for such a product.
by Jonathan Shan.
S.M.
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Hassan, Nurul Izzaty. „Revealing the art and science of self-replicating rotaxanes“. Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3128.
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This Thesis reveals the strategies for the construction and replication of mechanically interlocked molecules, particularly rotaxanes, which consist of a macrocyclic ring that encircles a linear component terminated with bulky groups. The work highlights our recent research activities in exploring the recognition-mediated synthesis of this class of interlocked molecule and its amplification by replication. Our starting point is the minimal model of self-replication. The introductory chapters (Chapter 1 and 2) provide some background and significance to the study, which presents comprehensive review of the published work carried out in the area of self-replication with existing examples from biomimetic and discrete synthetic assemblies. In Chapter 1, we mainly discuss the do and the donʼts in designing successful self-replicating systems based on our own experience in previous work. Our chief concerns in Chapter 2 are the understanding of the chemistry of the mechanical bond and the synthesis of rotaxanes by three means of approaches (clipping, threading and stoppering, and slippage). Attractive and useful examples are illustrated for each mechanism. Moreover, the definition and the roles of templated-synthesis of interlocked molecules are described. Recent advances in the understanding of the nature of the mechanical bond have also been introduced into molecular electronic devices. Emphasis is placed in Chapter 3 upon the essential requirements for the design of self-replicating rotaxanes, namely a recognition site, a reactive site and a binding site. These aspects are explained in the designed minimal model chosen in the past (Replication model 1) and the alternate proposed models (Replication model 2 and Replication model 3). The importance of high association constant to provide substantial amount of pseudorotaxane [L•M] precursors is exemplify in the simple kinetic model of rotaxane formation. The advantages and disadvantages of each independent minimal replication model are also summarized. In the self-replicating rotaxane frameworks, the principal strategy involves a selection of an efficient macrocycle to accommodate the guest unit. Thus, Chapter 4 exclusively describes the design, synthesis and binding properties of a series of macrocycle incorporating the hydrogen bond donors and/or hydrogen bond acceptors motif. In particular, the guests were designed and synthesised based on the mutual interactions with the macrocycle framework and the binding experiments is described in details. An account is provided of the problems faced in the synthetic attempts towards the formation of these macrocycles. The novel macrocycle MEU demonstrated a deficient binding performance with amide and urea compounds, and thus abandoned in later stages. The developed macrocycle MDG and MP have been selected as our workhorse macrocycles, which successfully increase the binding strength in the pseudorotaxanes formation. We have learnt that the association constant, Kₐ can be manipulated by the changing the binding site of the guest or redesign the framework of the macrocycle itself. An exhaustive investigation of the performance of self-replicating rotaxanes focuses on Replication model 1 is demonstrated in Chapter 5. It was evident now that as a consequence of low Kₐ, a substantial amount of thread is present over rotaxane. The implementation of the simple kinetic model of rotaxane formation is prevailed through out this chapter. The position of the central reversible equilibrium in this model effectively resulted in a different reactivity of thread and rotaxane. Therefore, it is concluded that the ratio of rotaxane and thread is sensitive to both the association constant for the [L•M] complex and to the ratio of k[subscript(rotaxane)]/k[subscript(thread)]. The key marker for the efficiency of the rotaxane-forming protocol is the ratio of rotaxane, R to thread, T. In previous chapter, the Kₐ for the [L•M] complex was around 100 M⁻¹ and k[subscript(T)] = 3 k[subscript(R)], which led to an unacceptably small [R]/[T] ratio. We demonstrated for the first time in Chapter 6, that it is possible to manipulate the Kₐ for the [L•M] complex by means of a change in temperature. Yields of a rotaxane can be improved by employing a two-step capture protocol. Cooling a solution of the linear and macrocyclic components required for the rotaxane increases the population of the target pseudorotaxane, which is then captured by a rapid capping reaction between an azide and PPh₃. The resulting iminophosphorane rotaxane can then be manipulated synthetically at elevated temperatures. Following this, these imines could be reduced readily to afford the stable amine rotaxane. Replication model 2 is subsequently proposed as alternate replication framework in Chapter 7, which realised significant advantages over the first model. A number of designs of a potential self-replicating rotaxane have been fabricated in order to integrate self-replication with the formation of rotaxanes. An account is provided of the problems faced with the unanticipated larger cavity of the newly prepared acid recognition macrocycles, and hence, force us to search for a new scaffold of the nitrone structures. Pleasingly, a substantial amount of rotaxane was present, mostly as trans diastereoisomer. It is concluded that the resulting rotaxane structures may be self-replicating through the recognition-mediated pathways from the preliminary kinetic experiments. Nonetheless, the remainder of the full kinetic analysis are prevented given a small quantity of the necessary building block. Chapter 8 reveals our recent efforts to demonstrate the notions behind the final replication scheme, Replication model 3. We have become aware that the reactive site must be placed sufficiently far away from the binding site to inhibit the remote steric effect through the proximity of the macrocyclic component. The design of novel nitrone structures is described in details. We bring together conclusions that can be drawn from three designated replication models in Chapter 9. Experimental and synthetic procedures of the target compounds and appropriate spectroscopic analysis of the products are elaborated in Chapter 10.
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Hjerpe, Daniel. „The destruction of life in a self replicating system“. Thesis, Uppsala universitet, Tillämpad matematik och statistik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355816.
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This thesis explores the question of why life can not be revived when death occurs due to lack of resources. For example, why can't something as simple as E.coli be revived after its death? The hypothesis is that death is not defined by the end of metabolism itself, but rather a continued metabolism which in turn destructs the entity itself. Consequently, a virus should not be capable of ”dying” due to its lack of metabolism. To study self replication, a recent mathematical model utilising Gillespie's algorithm and differential equations has been explored. Using this model, real systems such as the Formose reaction can be modeled. Furthermore, an analytical analysis has been carried out in order to study what impact a side reaction will have on a self replicating system's total growth rate. The result of the analysis states that the growth rate of a self replicating system peaks when all the reactions have the same reaction rate, and declines as the reaction rate of a side reaction increases. In conclusion, a self replicating system that either contains a side reaction or is coupled with another self replicating system can suffer an irreversible death. The reason for this is the metabolism that occurs when the resources have been depleted. At this point, other reactions not belonging to the main metabolism can destroy the self replication. This argument strengthens the hypothesis that a virus does not die in the same way as a living cell, as it does not have a metabolism of its own.
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Kapela, Cristopher A. „Confronting Plagiarism: Replicating Wheeler's Study in an ESL Environment“. University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo154455035758733.
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Ulanch, Rachel N., und Rachel N. Ulanch. „Replicating the Blue Wool Response Using a Smartphone Spectroradiometer“. Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625689.
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A spectroradiometer was developed using the rear camera of the Samsung S7 smartphone for replicating the response of blue wool, a light comparative fading test from the textile industry that was adopted by the art conservation community in the 1960s. This technique was regarded as a cost effective, readily available comparative standard for understanding lightfastness of museum objects, but not an end all solution. Many other solutions have been found since the suggestion of the blue wool standard. Including the Canadian Light Damage Calculator and Lightcheck® ,which are comparator guides for lighting museum objects. The Berlin model for comparing tested spectral data is taken with expensive equipment, to a database to determine an objects sensitivity. Microfadeometry that directly tests the object with a 0.4-mm diameter focused Xenon source that deteriorates the artwork. None however have been able to completely replace the vetted, cost effective, easy to use blue wool standard for determining the sensitivity of museum and gallery objects, but a solution is needed.
The solution is a designed and tested smartphone spectroradiometer attachment that measures the illumination and reflectance spectrum of museum and gallery objects to deduce an absorption spectrum that can be correlated to an expected blue wool response under the same conditions. The attachment for the phone is made from off the shelf and 3D printed parts. It has measured the deterioration of blue wool under a high intensity source and can predict the expected time for a blue wool specimen to visibly fade under the illumination of museum LED lighting.
This thesis covers the design, modeling and testing experiment for the smartphone spectroradiometer that currently has a resolution of ± 7 nm, a spectral range from 393 to 650 nm with five orders of magnitude and an absolute radiometric error of 27.5% with the possibility of room for improvement. This includes increasing the accuracy of the modeled spectrum of the sun used for calibration, applying more advanced noise removal techniques, applying filters in post processing for better resolution and of course using a smartphone that takes raw images and can have its optical image stabilizer turned off during manual mode.
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Lie-A-Cheong, Chadwick Lap Chung. „Studies of gene targeting with replicating vectors in human cells“. Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413631.
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Li, Jun. „Towards construction of synthetic ribosomes and a self-replicating system“. Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11433.
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In 2006, the Church Group, using biochemical approaches, hypothesized that ∼ 151 biomolecular components from Escherichia coli and its bacteriophages may be sufficient to enable rapid and accurate self–replication in vitro. However, efforts to construct such a system are precluded by our inability to sufficiently co–regenerate these 151 biomolecular components (or the components of ribosome — the key player of protein translation) and the inability to assemble E. coli ribosomes under conditions that are compatible with in vitro transcription and translation and also the lacking of evidence that functionally active ribosomes can be reconstituted from in vitro synthesized proteins and RNAs.
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Bery, B. R. „Volatility, liquidity and malleability : replicating the art of the 1960s“. Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1474178/.
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Reviewing Robert Morris’ 9 at Leo Castelli exhibition of December 1968, Max Kozloff used the terms volatility, liquidity and malleability. These physical characteristics suggest the precarious nature of the objects exhibited and are deployed throughout this thesis to explore the material, theoretical and ethical implications of sculpture replication in the twentieth century. A methodological approach that bridges art history and conservation-based perspectives will allow many of the current concerns surrounding replication to be expanded upon. The 1960s is seen as a key moment for the types of art objects being produced but also reproduced and a shift in practices and attitudes is traced. Issues of authenticity, materiality, authorship, historical narrative, conceptual intention and the various meanings ascribed to the term replica are considered. The purpose and status of the original or replica is scrutinised in the context of a history of replication. As a museum and artistic strategy, there are various motives for creating replicas. Here, a series of carefully selected historical case studies are used as test cases to draw attention to the acute problems posed when works are made from ephemeral or vulnerable materials, works that have to be performed, works that perform a process or behave naturally and works within a replicated exhibition enterprise. Concentrating on artworks produced in America and Europe, the thesis recasts artists and their works to highlight the precariousness of materials and meanings, documentation and actions, performativity and duration. A work’s inherent vice is seen in terms of what will be termed its ‘ephe-materiality’ and its replica as a re-action in the continuous present. The relationship of surface to support, materials that act out or perform their own instability, provides a platform from which to readdress the idea of a single, finished work and its exhibitable life and afterlife within a museum today.
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Laos, Roberto, und Steven Benner. „The first self-replicating molecule and the origin of life“. Revista de Química, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/99479.
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El origen de la vida en la Tierra es una de las preguntas más difíciles presentadas a la ciencia. En los últimos 60 años, ha habido un progreso considerable en entender cómo moléculas relativamente sencillas, que son relevantes para la vida, pueden ser generadas espontáneamente o pueden llegar a la Tierra desde el espacio. Además, los análisis de la evolución de la historia de ácidos nucleicos, los cuales almacenan la información genética, apuntan a un ancestro común universal ya extinto. Los estudios del origen de la vida ofrecen muchas pistas que apuntan hacia un origen común, quizás no solo en el Tierra sino también en algún otro punto del sistema solar. Debido al largo tiempo transcurrido desde que la Tierra empezó a albergar vida, las pistas más antiguas de los primeros organismos se han perdido. Es muy poco probable encontrar exactamente cómo fue este primer organismo. Sin embargo, en los últimos años la biología sintética ha logrado progresar mucho en la modificación de biomoléculas, en particular, los ácidos nucleicos. Es posible que pronto podamos construir y comprender un sistema minimalista en el cual las moléculas puedan copiarse a sí mismas dentro de una célula rudimentaria. El estudio de un sistema así podría permitirnos develar el origen de los primeros organismos.The origin of life on Earth is one of the most challenging questions in science. In the last 60 years, considerable progress has been made in understanding how simple molecules relevant to life can be generated spontaneously or are known to arrive to Earth from space. Additionally, analysis of the evolution history of nucleic acids, which are the repository of genetic information, points to a now extinct, universal common ancestor for all life on Earth. The studies of the origin of life offer many clues towards a common origin, perhaps not just on Earth but somewhere else in the solar system. However due to the length of time that the Earth has harbored life, the oldest clues of the first organisms are mostly gone. It is unlikely to find exactly what this first organism was like. Nevertheless, in the last few years, synthetic biology has made remarkable progress at modifying biomolecules, particularly nucleic acids. It is possible that soon we will be able to construct and understand a minimalistic system in which molecules can copy themselves in a protocell. The study of such systems could shed light into the origin of the first organisms.
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Eliasson, Ludvig. „Replicating movement and behaviour of different cloths for VFX-production“. Thesis, Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-63849.
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This thesis discusses cloth simulations for visual effects production, and thereplication of real life garments in that context. The purpose is to get anunderstanding for the practical process of recreating actual cloth garments, andthrough this work explore the behaviour of cloth materials and the importance of theirspecific traits in a simulation context. This is achieved through recreating threespecific cloth garments in a computer simulation package, cross-referencingobserved cloth properties as guidance. The resulting videos are then compared sideby side with filmed reference by the author and through a survey, along with similarlooking simulations to evaluate the quality of the simulations. The results show that itis possible to digitally recreate real world garments, with accuracy being mostlydepending on resolution, model accuracy and apparent thickness. The report alsohighlights a need for further research into tangible cloth recreation.
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Urtel, Georg [Verfasser], und Dieter [Akademischer Betreuer] Braun. „Evolutionary processes in replicating DNA species / Georg Urtel ; Betreuer: Dieter Braun“. München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1117474100/34.
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Wang, Bing. „A self replicating reaction and a new approach to ionophore selection“. Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337144.
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McAlear, Michael A. „Isolation and characterization of origin-enriched sequences from early-replicating human cells“. Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70264.
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The objective of this thesis is to research at the molecular level the mechanisms involved in the initiation of mammalian DNA replication. Human WI-38 cells were synchronized to the G1/S border by serum starvation and aphidicolin block. Cells were relased from arrest and followed as they progressed into S phase by microfluorometric analysis. Early replicating DNA was extruded from replication bubbles, purified from the high molecular weight parental DNA and cloned into the NruI site of pBR322. The recombinant plasmids were surveyed for properties previously associated with origins of replication. In a random sample of 10 human origin enriched sequences (hors) that were analyzed, 5 were capable of autonomous replication in a transient BrdU substitution assay. Two clones contained DNA fragments that migrate anomalously on acrylamide gels suggestive of bent DNA. One clone contained a weak DNA unwinding element as judged by sensitivity to the single strand specific enzyme mung bean nuclease. Primary sequence analyses of five of the hors clones (hors 98, 106, 112, 129 and 133) revealed that they were enriched for the AP2-A, NF-1 related and iron response consensus sequences. The replicating clones also contained potential cruciform structures within 50 bp of an A/T rich region. A DNA binding activity was identified in HeLa nuclear extracts that binds to a sub-fragment of one of the replicating clones (hors106) by bandshift assays and it was partially purified by DEAE and PC-11 column chromatography.
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Wong, Shu-hing Louise. „Replicating mesenchymal cells in the glenoid fossa in response to mandibular advancement“. Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B31973140.
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黃淑興 und Shu-hing Louise Wong. „Replicating mesenchymal cells in the glenoid fossa in response to mandibular advancement“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31973140.
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Doyle, Paul G. „Replicating corpus linguistics : a corpus-driven investigation of lexical networks in text“. Thesis, Lancaster University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418685.
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Mosley, David W. „Two-dimensional polymer synthesis : towards a two-dimensional replicating system for nanostructures“. Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33652.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.Vita.
Includes bibliographical references
The general concept of a replicating monolayer system is introduced as a new method of nanostructure synthesis. One possible implementation of a 2-D replicating system is pursued which uses a diacetylene moiety for cross-linking and amide hydrogen bonding for molecular recognition between replicates and templates. The synthesis of several monomers for amide hydrogen-bonded adlayer formation is described. The assembly and crosslinking of diacetylene monomers on an underlying amide-capped self- assembled monolayer (SAM) was studied on unpatterned thermally evaporated gold films. Raman and Fourier-transform infrared spectroscopies, as well as ellipsometry and contact angle data, indicate that amide hydrogen bonding interactions are sufficient to organize an adlayer of diacetylene-containing molecules on the underlying SAM which can be polymerized with ultraviolet light. In order to obtain gold substrates suitable for cross-linking of bis(diacetylene) monomers, new methods of producing ultraflat gold surfaces were developed.
(cont.) A solid- state bonding technique using only gold was developed, yielding ultraflat gold surfaces, with root-mean-square roughnesses of -0.5 nm, on glass slides which are free of impurities from epoxies or other bonding agents. The patterning and cross-linking of poly(diacetylene) adlayers on ultraflat gold surfaces was investigated by atomic force microscopy (AFM). Soft lithography was suitable for adlayer structures down to about 500 nm. Electron beam lithography for patterning of polymerizable adlayers was demonstrated for the first time. The polymerized adlayer patterns were significantly more difficult to remove from the gold surface than unpolymerized adlayer patterns, indicating cross-linking. Studies to remove adlayer patterns as intact 2-D polymers failed, due either to poor cross-linking or robustness of the resulting 2-D polymers. In another approach to nanostructure synthesis, the synthesis of monofunctionalized gold nanoparticles by a solid phase synthetic route was described. This represents a versatile method of producing monofunctionalized nanoparticles, which can be used to produce and study more elaborate nanoparticle structures.
by David W. Mosley.
Ph.D.
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Sedlackova, Anna. „Replicating Motion Vision and Response in Insects Using a Synthetic Nervous System“. Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1593309220545937.
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Stefanou, Eleni. „Aspects of identity and nationhood : commemorating, representing and replicating the Greek maritime past“. Thesis, University of Southampton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494688.
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Hafneh, Nor Azian. „Investigation of molecular factors involved in mycobacterial stress responses and non-replicating persistence“. Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42533.
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Mycobacterium tuberculosis is a remarkably successful human pathogen due to its ability to switch into dormancy or non-replicating persistence (NRP) phase driven by the host stress microenvironments. Identifying the panoply of genes or pathways involved in dormancy will progress our understanding on latent tuberculosis infection. Rv2660c and Rv2661c (conserved hypothetical proteins) and Rv1675c (transcriptional regulator) were implicated in mycobacterial stress response and transition to dormancy, hence their biological importance in M. tuberculosis biology was further explored. Rv2660c and rv2661c were highly upregulated in vitro starvation and in vivo infection model, however, recent high upregulation of a noncoding RNA, ncRv12659 in these models challenged the importance of these genes for NRP. A panel of single and double in-frame deletion mutants and over-expressing strains of rv2660c and rv2661c in M. tuberculosis were generated. A deletion of rv2660c and rv2661c also resulted in partial inactivation of ncRv12659 and rv2662 respectively. The deletion mutants exhibited normal growth in vitro and in mice. Furthermore, the strains showed unimpaired survival under nutrient starvation, hypoxia, oxidative and nitrosative stresses. Quantitative RT-PCR analysis revealed that neither target gene was highly expressed throughout starvation, oxidative and acidic pH stresses. Rv1675c (Cmr) is a redox sensor that regulates the DosR signalling pathway. Cmr binding to DNA was severely reduced by nitrosation of the two conserved cysteine residues. The cmr mutant displayed survival advantage during exposure to nitrosative stress. The over-expression of cmr or cmrC2A form (mutated cysteines) had a mild inhibitory effect on growth of M. tuberculosis. The over-expressing strain of cmrC2A was more resistant to hydrogen peroxide, suggesting that Cmr may also control the response to oxidative stress. Our study clarified the role of Rv2660c and Rv2661c in growth, NRP and infection, and further highlighted a novel Cmr-mediated regulatory network involved during nitrosative stress and transition to dormancy.
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Shaw, Garth. „Replicating a habitus: transplanting capital, habitus and doxa in a school start-up“. Doctoral thesis, Faculty of Humanities, 2019. https://hdl.handle.net/11427/31734.
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Schooling in South Africa still reflects the inequalities of apartheid. The majority of learners live in low socioeconomic contexts, and face challenges accessing ‘quality’ education, which is largely only available at expensive, fee charging schools. Even if poorer learners do gain access to these schools, which are in the minority, they are not always optimally supported nor understood in terms of their challenges at home or needs at school. One response to this dilemma, by the Western Cape Education Department, was to establish a school seeking to produce ‘quality’ education, but focused on the needs of poorer learners. The founding of this school is the focus of this study. Modelled on, and guided by an established, high performing and geographically proximate school, located in an affluent community, this ‘school planting intervention’ took place over a three year start-up period. Drawing on Pierre Bourdieu’s concepts of habitus, doxa, capital and field, this case study examines how the institutional habitus of the established school, its capitals, and its position in the field of education have impacted the establishment of the new school. The study draws on data gathered from extensive interviews with school managers, teachers, parents and learners at both schools. The research process has also been supplemented by a contextual grounding of the project, with the researcher positioned as an inside-researcher. The strategies of the school planting interaction are considered, and the responses of various groups within the new school interrogated. In doing so, this study examines the implicit assumptions in practices and arrangements that are considered to be exemplary in a high performing school, and the ways in which these relate to the different needs and experiences of middle class and working class learners. The study finds that, while there were practical benefits to providing systemic support to the new school, there was also a profound disjuncture between assumptions about what constitutes ‘good practice’, grounded in a middle class experience, and the needs and experiences of poorer learners.
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Walker, Michael Monroe. „Replicating the Effects of a Passive Boundary-Layer Fence via Active Flow Control“. The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524146958877311.
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Pirlo, Steven Dominic. „Identification of viral-based replicating vectors suitable for the development of a sugarcane bioreactor“. Queensland University of Technology, 2007. http://eprints.qut.edu.au/16548/.
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The circular, single-stranded (ss) DNA genomes of plant viruses in the families Geminiviridae and Nanoviridae are replicated within the nucleus of a host cell by a mechanism called rolling circle replication (RCR). Although this process relies almost exclusively on the replication machinery of the host cell, initiation occurs via the interaction of the viral replication initiation protein (Rep) with regulatory DNA sequences within the viral genome. The use of a virus-based episomal amplification technology as a plant bioreactor platform exploits the process of Rep-mediated RCR for the high-level amplification of virus-based episomes in plants and subsequent expression of heterologous proteins; such an approach offers advantages over existing gene expression technologies. This PhD thesis describes research towards the development of a virus-based episomal amplification system for use in sugarcane. Such a crop is ideally suited for a plant bioreactor system due to the efficient high-level production of plant biomass and the existence of established production, harvesting and processing infrastructure. In order to rapidly assess the potential of a virus-based episomal amplification system in sugarcane, a transient assay system was established. Sugarcane callus was identified as the most suitable cell preparation; providing rapid cell regeneration, uniform experimental samples and upon isolation, total DNA suitable for Southern analysis. This assay system once established, proved effective in rapidly identifying virus-based episomes capable of undergoing RCR within sugarcane host cells. This transient assay system was then used to test the functionality of a virus-based episomal amplification system based on the ssDNA virus, Banana bunchy top virus (BBTV) in sugarcane. BBTV-based episomal amplification vectors were constructed with a reporter gene expression cassette flanked by two copies of the BBTV regulatory DNA sequences. The episomal amplification vectors were bombarded into sugarcane and banana host cells in various combinations and evidence of RCR was assessed through Southern blot analysis. RCR products were identified in banana host cells bombarded with the BBTV-based episomal amplification vectors in combination with vectors encoding BBTV Master-Rep (M Rep). RCR products were not identified within sugarcane cells bombarded with the same construct combinations. Integrated InPAct (In Plant Activation) episomal vectors based on BBTV were then employed to confirm the transient results, in addition, the functionality of an InPAct vector based on an alternate virus, Tobacco yellow dwarf virus (TYDV) was also assessed. InPAct vectors based on BBTV were constructed with an untranslatable expression cassette for integration within the sugarcane genome. Transient experiments were performed to assess the ability of BBTV M-Rep and TYDV Rep to initiate RCR of their respective InPAct vectors. Visual observation of GFP expression indicated that BBTV M-Rep was capable of initiating RCR of the BBTVbased InPAct vectors within banana host cells but no evidence was observed in sugarcane host cells. TYDV Rep was capable of initiating RCR of the TYDV-based InPAct vector within sugarcane host cells with a 100-fold increase in the number of fluorescent foci compared to cells bombarded with the TYDV InPAct vector alone. The BBTV-based InPAct vector was stably integrated within the sugarcane genome and the ability for BBTV M-Rep to initiate episome formation and RCR was assessed by Southern blot analysis. Evidence of BBTV M-Rep mediated RCR was not detected within the transgenic sugarcane bombarded with BBTV M-Rep. Transgenic sugarcane containing the TYDV-based InPAct vectors was assessed for the ability to be activated by TYDV Rep and undergo RCR. Southern blot analysis demonstrated that TYDV Rep was capable of recognising the integrated TYDVbased InPAct vector and RCR was detected within the transgenic sugarcane. The observation that episomal vectors based on TYDV were functional within sugarcane host cells and BBTV-based vectors were not, was unexpected. It had been hypothesised that an episomal vector based on a monocot-infecting virus would replicate in an alternate monocot host, while an episomal vector based on a dicot infecting virus would not. Virus replication is thought to be host-specific however most host range studies have been conducted with full length infectious clones and not deconstructed virus-based episomes. The implication that viral Reps may be functional in plant cells of non-host species was then investigated. The ability for viral Reps to recognise their cognate IR and initiate RCR of virus-based episomes in different host cells was assessed through cross-replication experiments. Four ssDNA plant viruses; BBTV, TYDV, Chloris striate mosaic virus (CSMV) and Tomato leaf curl virus - Australia (ToLCV-Au) were assessed via Southern blot analysis for their ability to initiate both autonomous replication of infectious clones and episomal amplification within three different plant hosts; tobacco, sugarcane and banana. Results from cross replication studies indicated a complex interaction between viral and host replication components. BBTV infectious clones and episomal vectors were restricted to replication within banana host cells providing a clear indication that episomal amplification vectors based on BBTV are restricted to Musa spp. BBTV M-Rep was unable to recognise the viral regulatory DNA sequences of the other three ssDNA viruses. TYDV infectious clones and episomal vectors were capable of replicating within all three host cells tested, indicating that TYDV is capable of undergoing RCR within a broad range of plant hosts. TYDV Rep was also capable of recognising the viral regulatory DNA sequences of both CSMV and BBTV given favourable conditions within specific plant hosts. Replication of the CSMV infectious clone was not detected in any of the three host cells, although fidelity of this clone requires further confirmation. CSMV episomal vectors were functional within banana host cells only, indicating that although closely related to TYDV, episomal amplification vectors based on CSMV have a restricted host range. CSMV Rep could not initiate RCR of episomal amplification vectors containing the viral regulatory DNA regions of the other three viruses in any of the plant host cells. ToLCV-Au infectious clones were capable of replicating within banana and tobacco host cells. Episomal amplification vectors based on ToLCV-Au extended the host range to sugarcane. ToLCV-Au Rep was unable to recognise the viral regulatory DNA sequences of the other three viruses in any of the plant host cells. The ability for a viral Rep to recognise its own cognate regulatory DNA sequences within alternate plant host cells is variable. Episomal amplification vectors based on TYDV and ToLCV-Au appear to be the most suitable for the further development of a virusbased bioreactor system in sugarcane. This study details the initial steps taken towards the development of a virus-based episomal amplification system in sugarcane. In doing so, fundamental knowledge into the mechanisms involved in Rep recognition of viral regulatory DNA sequences has been gathered. These research findings will provide a solid foundation for the further development of a sugarcane-based bioreactor.
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Wong, Gerald. „Snapshot hyperspectral imaging : near-infrared image replicating imaging spectrometer and achromatisation of Wollaston prisms“. Thesis, Heriot-Watt University, 2012. http://hdl.handle.net/10399/2615.
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Conventional hyperspectral imaging (HSI) techniques are time-sequential and rely on temporal scanning to capture hyperspectral images. This temporal constraint can limit the application of HSI to static scenes and platforms, where transient and dynamic events are not expected during data capture. The Near-Infrared Image Replicating Imaging Spectrometer (N-IRIS) sensor described in this thesis enables snapshot HSI in the short-wave infrared (SWIR), without the requirement for scanning and operates without rejection in polarised light. It operates in eight wavebands from 1.1μm to 1.7μm with a 2.0° diagonal field-of-view. N-IRIS produces spectral images directly, without the need for prior topographic or image reconstruction. Additional benefits include compactness, robustness, static operation, lower processing overheads, higher signal-to-noise ratio and higher optical throughput with respect to other HSI snapshot sensors generally. This thesis covers the IRIS design process from theoretical concepts to quantitative modelling, culminating in the N-IRIS prototype designed for SWIR imaging. This effort formed the logical step in advancing from peer efforts, which focussed upon the visible wavelengths. After acceptance testing to verify optical parameters, empirical laboratory trials were carried out. This testing focussed on discriminating between common materials within a controlled environment as proof-of-concept. Significance tests were used to provide an initial test of N-IRIS capability in distinguishing materials with respect to using a conventional SWIR broadband sensor. Motivated by the design and assembly of a cost-effective visible IRIS, an innovative solution was developed for the problem of chromatic variation in the splitting angle (CVSA) of Wollaston prisms. CVSA introduces spectral blurring of images. Analytical theory is presented and is illustrated with an example N-IRIS application where a sixfold reduction in dispersion is achieved for wavelengths in the region 400nm to 1.7μm, although the principle is applicable from ultraviolet to thermal-IR wavelengths. Experimental proof of concept is demonstrated and the spectral smearing of an achromatised N-IRIS is shown to be reduced by an order of magnitude. These achromatised prisms can provide benefits to areas beyond hyperspectral imaging, such as microscopy, laser pulse control and spectrometry.
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蔡明汝 und Ming-ju Marjorie Tsai. „Replicating mesenchymal cells in the condyle in response to normal growth and mandibular protrusion“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31973127.
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Tsai, Ming-ju Marjorie. „Replicating mesenchymal cells in the condyle in response to normal growth and mandibular protrusion“. Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25575995.
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Chun, Scott Bong-Soo. „A Reusable Persistence Framework for Replicating Empirical Studies on Data from Open Source Repositories“. BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2371.
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Empirical research is inexact and error-prone leading researchers to agree that replication of experiments is a necessary step to validating empirical results. Unfortunately, replicating experiments requires substantial investments in manpower and time. These resource requirements can be reduced by incorporating component reuse when building tools for empirical experimentation. Bokeo is an initiative within the Sequoia Lab of the BYU Computer Science Department to develop a platform to assist in the empirical study of software engineering. The i3Persistence Framework is a component of Bokeo which enables researchers to easily build and rapidly deploy tools for empirical experiments by providing an easy-to-use database management service. We introduce the i3Persistence Framework of Bokeo to assist in the development of software to replicate experiments and conduct studies on data from open-source repositories.
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Santana, Deanna J. „Replicating an economic development corporation : recreating new economics for women (NEW) in Oakland, California“. Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/70259.
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Øien, Beate. „Revisiting Foreign Direct Investment and Collective Labor Rights : Replicating "the positive case" of economic globalization“. Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sosiologi og statsvitenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-13777.
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Henson, Larry D. „Reliability of system detector data in replicating field conditions for the integrated motorist information system“. Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/20304.
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Ramesh, Anuradha. „Replicating and extending job embeddedness across cultures employee turnover in India and the United States /“. College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/6841.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.Thesis research directed by: Psychology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Emerson, George F. „Replicating an English virginal with an historical perspective of virginals and virginal books in England“. Virtual Press, 1987. http://liblink.bsu.edu/uhtbin/catkey/495118.
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This project involved an examination of the relative popularity of various harpsichords and related keyboard instruments in England from 1150 to 1820, with particular attention to the virginal period, 1500 to 1680. Considerable research was involved in selecting an appropriate instrument to replicate and the methodology of its builder. Attention was given to the appropriateness of certain bodies of literature to particular instrument types, with special attention to English virginal literature. In order to understand fully the relationship between an instrument type and its literature, it was further necessary to draw comparisons between the physical and musical features of the various harpsichord types which might influence the suitability of the instrument to the literature.The culmination of the project was the building of a virginal based upon the findings of the research. The instrument chosen for replication was the 1668 Stephen Keene virginal built in London.
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Cody, James Joseph. „A dual-action, armed replicating adenovirus for the treatment of bone metastases of breast cancer“. Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/cody.pdf.
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McCaul, Emily Patricia. „Replicating the Kaepernick Effect: The Power of Polarizing Frames to Make or Break Consumer Loyalty“. Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/99296.
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This thesis evaluates the ways media frames influence attitude towards brands when the brand endorses a controversial celebrity spokesperson. This research was created with the intent to fill a current gap in communication research, providing original data and addressing the influence that external factors, specifically media frames and political orientations, hold over an audience's perception of spokespeople and the brands they later endorse. This was accomplished through an original, cross-sectional experiment that measured how celebrity athletes, who speak out about partisan issues, function as agents for messaging in brand advertisements. This thesis draws upon the communication theories of agenda setting, and primarily framing, in order to evaluate how impactful media frames of an athlete can become to consumers once the media highlights the spokesperson through a polarizing frame. This experiment attempts to replicate 'the Kaepernick effect,' inspired by the polarizing media coverage of Colin Kaepernick over his 2016-NFL season with the 49-ers, leading up to his partnership with Nike for its 2018 "Dream Crazy" advertisement. The findings from this study reveal that media frames, though carrying some impact, are not the most influential factor in shaping audiences' attitudes towards spokespeople or the brands they advertised. This study contributes new data to the discipline of media effects research, extending the conversation about celebrity athlete endorsers, the influence of media frames on consumer response, and implications for future studies.Master of Arts
This thesis looks at the effects that media frames, within news stories, have on audiences' attitudes and behaviors. Specifically, this thesis examines audiences' developed attitudes towards controversial celebrity spokespeople, who speak out about partisan issues, and later endorse or align themselves with a brand. This thesis utilizes an original experiment that measures how controversial celebrity figures, athletes specifically, function as agents for messaging in brand advertisements. This thesis draws upon the communication theories of agenda setting, and primarily framing, in order to evaluate how impactful media frames of an athlete can become to consumers once the media highlights the spokesperson through a polarizing frame. This experiment attempts to replicate 'the Kaepernick effect,' inspired by the polarizing media coverage of Colin Kaepernick over his 2016-NFL season with the 49-ers, leading up to his partnership with Nike for its 2018 "Dream Crazy" advertisement. The findings from this study reveal that media frames, though carrying some impact, are not the most influential factor in shaping audiences' attitudes towards spokespeople or the brands they advertised. This study contributes new data to the discipline of media effects research, extending the conversation about celebrity athlete endorsers, the influence of media frames on consumer response, and implications for future studies.