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Fan, Kuo Chin, Cheng Wen Liu, and Yuan Kai Wang. "A randomized approach with geometric constraints to fingerprint verification." Pattern Recognition 33, no. 11 (2000): 1793–803. http://dx.doi.org/10.1016/s0031-3203(99)00182-x.
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Kho, Jun Beom, Jaihie Kim, Ig-Jae Kim, and Andrew B. J. Teoh. "Cancelable fingerprint template design with randomized non-negative least squares." Pattern Recognition 91 (July 2019): 245–60. http://dx.doi.org/10.1016/j.patcog.2019.01.039.
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Jin, Zhe, Meng-Hui Lim, Andrew Beng Jin Teoh, and Bok-Min Goi. "A non-invertible Randomized Graph-based Hamming Embedding for generating cancelable fingerprint template." Pattern Recognition Letters 42 (June 2014): 137–47. http://dx.doi.org/10.1016/j.patrec.2014.02.011.
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Narang*, Deepak, Aruna Das, Praveen Kumar, et al. "Dermatoglyphics (finger prints) as predilection marker for impacted teeth: A randomized blind trial." International Journal of Bioassays 5, no. 09 (2016): 4851. http://dx.doi.org/10.21746/ijbio.2016.09.0012.
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Impacted teeth are teeth which remain embedded in the jaws past their normal eruption time or which have been blocked from their normal eruption path because of crowding of adjacent teeth or lack of enough jaw size to accommodate their eruption. Impacted teeth can cause a number of problems if left in place. Dermatoglyphics is the study of skin patterns and finger ridges that present on the fingers, toes and the soles. Fingerprint patterns of both hands were analyzed among ten patients with impacted teeth seen clinically and radiographically and equal number of healthy subjects. This study showed that tented arch pattern in index fingers of both the hands has been observed in impacted subjects thus serving as an indicator of genetic susceptibility in the incidence of dental impaction.
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Fan, Siyan, Samaneh Nemati, Teddy J. Akiki, et al. "Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder." Chronic Stress 4 (January 2020): 247054702098472. http://dx.doi.org/10.1177/2470547020984726.
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Background Major depressive disorder (MDD) treatment is characterized by low remission rate and often involves weeks to months of treatment. Identification of pretreatment biomarkers of response may play a critical role in novel drug development, in enhanced prognostic predictions, and perhaps in providing more personalized medicine. Using a network restricted strength predictive modeling (NRS-PM) approach, the goal of the current study was to identify pretreatment functional connectome fingerprints (CFPs) that (1) predict symptom improvement regardless of treatment modality and (2) predict treatment specific improvement. Methods Functional magnetic resonance imaging and behavioral data from unmedicated patients with MDD (n = 200) were investigated. Participants were randomized to daily treatment of sertraline or placebo for 8 weeks. NRS-PM with 1000 iterations of 10 cross-validation were implemented to identify brain connectivity signatures that predict percent improvement in depression severity at week-8. Results The study identified a pretreatment CFP that significantly predicts symptom improvement independent of treatment modality but failed to identify a treatment specific CFP. Regardless of treatment modality, improved antidepressant response was predicted by high pretreatment connectivity between modules in the default mode network and the rest of the brain, but low external connectivity in the executive network. Moreover, high pretreatment internal nodal connectivity in the bilateral caudate predicted better response. Conclusions The identified CFP may contribute to drug development and ultimately to enhanced prognostic predictions. However, the results do not assist with providing personalized medicine, as pretreatment functional connectivity failed to predict treatment specific response.
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Moré, Margret, Joerg Gruenwald, Ute Pohl, and Ralf Uebelhack. "A Rosa canina – Urtica dioica – Harpagophytum procumbens/zeyheri Combination Significantly Reduces Gonarthritis Symptoms in a Randomized, Placebo-Controlled Double-Blind Study." Planta Medica 83, no. 18 (2017): 1384–91. http://dx.doi.org/10.1055/s-0043-112750.
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AbstractThe special formulation MA212 (Rosaxan) is composed of rosehip (Rosa canina L.) puree/juice concentrate, nettle (Urtica dioica L.) leaf extract, and devilʼs claw (Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract and also supplies vitamin D. It is a food for special medical purposes ([EU] No 609/2013) for the dietary management of pain in patients with gonarthritis.This 12-week randomized, placebo-controlled double-blind parallel-design study aimed to investigate the efficacy and safety of MA212 versus placebo in patients with gonarthritis.A 3D-HPLC-fingerprint (3-dimensional high pressure liquid chromatography fingerprint) of MA212 demonstrated the presence of its herbal ingredients. Ninety-two randomized patients consumed 40 mL of MA212 (n = 46) or placebo (n = 44) daily. The Western Ontario and McMaster Universities Arthritis Index (WOMAC), quality-of-life scores at 0, 6, and 12 weeks, and analgesic consumption were documented. Statistically, the initial WOMAC subscores/scores did not differ between groups. During the study, their means significantly improved in both groups. The mean pre-post change of the WOMAC pain score (primary endpoint) was 29.87 in the MA212 group and 10.23 in the placebo group. The group difference demonstrated a significant superiority in favor of MA212 (pU < 0.001; pt < 0.001). Group comparisons of all WOMAC subscores/scores at 6 and 12 weeks reached same significances. Compared to placebo, both physical and mental quality of life significantly improved with MA212. There was a trend towards reduced analgesics consumption with MA212, compared to placebo. In the final efficacy evaluation, physicians (pChi < 0.001) and patients (pChi < 0.001) rated MA212 superior to placebo. MA212 was well tolerated.This study demonstrates excellent efficacy for MA212 in gonarthritis patients.
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Corsetto, Paola Antonia, Gigliola Montorfano, Catherine Klersy, et al. "Fatty Acid Profile and Antioxidant Status Fingerprint in Sarcopenic Elderly Patients: Role of Diet and Exercise." Nutrients 11, no. 11 (2019): 2569. http://dx.doi.org/10.3390/nu11112569.
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Plasma fatty acids (FAs) and oxidant status contribute to the etiology of sarcopenia in the elderly concurring to age-related muscle loss and elderly frailty through several mechanisms including changes in FA composition within the sarcolemma, promotion of chronic low-grade inflammation, and insulin resistance. The aim of this study was to determine the FA profile and pro-antioxidant status in sarcopenic frail elderly patients enrolled in a nutritional and physical activity program and to evaluate their correlation with clinical markers. Moreover, the possible changes, produced after a short-term clinical protocol, were evaluated. Plasma and erythrocyte FA composition and pro-antioxidant status were analyzed in sarcopenic elderly subjects recruited for the randomized clinical study and treated with a placebo or dietary supplement, a personalized diet, and standardized physical activity. Subjects were tested before and after 30 days of treatment. Pearson correlations between biochemical parameters and patients’ characteristics at recruitment indicate interesting features of sarcopenic status such as negative correlation among the plasma FA profile, age, and physical characteristics. Physical activity and dietetic program alone for 30 days induced a decrease of saturated FA concentration with a significant increase of dihomo-gamma-linolenic acid. Supplementation plus physical activity induced a significant decrease of linoleic acid, omega-6 polyunsaturated FAs, and an increase of stearic and oleic acid concentration. Moreover, glutathione reductase activity, which is an indicator of antioxidant status, significantly increased in erythrocytes. Changes over time between groups indicate significant differences for saturated FAs, which suggest that the amino acid supplementation restores FA levels that are consumed during physical activity. A relationship between FA and clinical/metabolic status revealed unique correlations and a specific metabolic and lipidomic fingerprint in sarcopenic elderly. The results indicate the positive beneficial role of supplementation and physical activity on plasma FA status and the antioxidant system as a co-adjuvant approach in sarcopenic, frail, elderly patients.
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Thiesen, Felix Christian, Reinhard Kopiez, Christoph Reuter, and Isabella Czedik-Eysenberg. "A snippet in a snippet: Development of the Matryoshka principle for the construction of very short musical stimuli (plinks)." Musicae Scientiae 24, no. 4 (2019): 515–29. http://dx.doi.org/10.1177/1029864918820212.
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For the past 140 years, numerous studies have been conducted to examine minimum durations of samples needed for the recognition of acoustic parameters such as pitch, timbre or vocal phonemes. Recent studies in this field are often based on short clips (plinks) of popular songs, using target variables such as titles and interpreters. These studies provide strong evidence that a wide range of intra- and extramusical information can be identified above chance level for stimuli lasting much shorter than a second. Nevertheless, a review of precedent studies revealed a heterogeneity in stimulus generation processes that could have influenced overall recognition rates. As a piece of music unfolds in time, its timbral structure is subject to a variety of changes. We assume that the position of stimulus extraction, therefore, could influence the outcomes of a subsequent recognition task, for instance. In this study, we offer a systematic and objective stimulus extraction procedure that might help to control for (a) a possible confounding of stimulus duration and timbre (caused by the extraction of stimulus sets of various length from different song positions), (b) possible confoundings of song section and timbre (caused by the comparison of stimulus sets from divergent song sections), and (c) the suspected influence of subjective criteria on extract selection (caused by the non-randomized selection of extract positions). As an alternative approach, the suggested Matryoshka principle produces randomized sets of nested stimuli controlled for song position and objective selection. Each set represents an individual section and consists of five short excerpts, cut from each other in decreasing duration. Correlation analyses confirmed that these sets prove to be stable in terms of their mel-frequency cepstrum coefficients, the so-called “psycho-acoustic fingerprint” of a sound. Based on the software Random Plink Generator, the suggested procedure can help to contribute to an objective selection of stimuli in future plink research.
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Fan, Qian, Xin-Chun Yang, Yu Liu, et al. "Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans." Clinical Science 120, no. 6 (2010): 251–61. http://dx.doi.org/10.1042/cs20100369.
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In the present study, we hypothesized that postcon (postconditioning) confers cardioprotection in vivo by reducing the production of ONOO− (peroxynitrite) and nitro-oxidative stress subsequent to the inhibition of the iNOS (inducible NO synthase). Patients with AMI (acute myocardial infarct) were randomly assigned to undergo percutaneous coronary intervention without (control) or with ischaemic postcon by three episodes of 30-s inflation and 30-s deflation of the angioplasty balloon. Animal models of MI/R (myocardial ischaemia/reperfusion) injury were induced in rats by occluding the left coronary artery for 40 min followed by 4-h reperfusion. Rats were randomized to receive vehicle, postcon (three cycles of 10-s reperfusion and 10-s coronary re-occlusion preceding full reperfusion), the selective iNOS inhibitor 1400W or postcon plus 3-morpholinosydnonimine (an ONOO− donor). Postcon in patients reduced iNOS activity in white blood cells, decreased plasma nitrotyrosine, a fingerprint of ONOO− and an index of nitro-oxidative stress, and improved cardiac function (P<0.01 compared with control). In rats, postcon reduced post-ischaemic myocardial iNOS activity and nitrotyrosine formation, reduced myocardial infarct size (all P<0.05 compared with control) and improved cardiac function. Administration of 1400W resembled, whereas 3-morpholinosydnonimine abolished, the effects of postcon. In conclusion, reduction in ONOO−-induced nitro-oxidative stress subsequent to the inhibition of iNOS represents a major mechanism whereby postcon confers cardioprotection in vivo.
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Dutta, Kumar, Hyett, and Salomon. "Molecular Targets of Aspirin and Prevention of Preeclampsia and Their Potential Association with Circulating Extracellular Vesicles during Pregnancy." International Journal of Molecular Sciences 20, no. 18 (2019): 4370. http://dx.doi.org/10.3390/ijms20184370.
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Uncomplicated healthy pregnancy is the outcome of successful fertilization, implantation of embryos, trophoblast development and adequate placentation. Any deviation in these cascades of events may lead to complicated pregnancies such as preeclampsia (PE). The current incidence of PE is 2–8% in all pregnancies worldwide, leading to high maternal as well as perinatal mortality and morbidity rates. A number of randomized controlled clinical trials observed the association between low dose aspirin (LDA) treatment in early gestational age and significant reduction of early onset of PE in high-risk pregnant women. However, a substantial knowledge gap exists in identifying the particular mechanism of action of aspirin on placental function. It is already established that the placental-derived exosomes (PdE) are present in the maternal circulation from 6 weeks of gestation, and exosomes contain bioactive molecules such as proteins, lipids and RNA that are a “fingerprint” of their originating cells. Interestingly, levels of exosomes are higher in PE compared to normal pregnancies, and changes in the level of PdE during the first trimester may be used to classify women at risk for developing PE. The aim of this review is to discuss the mechanisms of action of LDA on placental and maternal physiological systems including the role of PdE in these phenomena. This review article will contribute to the in-depth understanding of LDA-induced PE prevention.
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Yohanista, Maria. "PAKAN AMPAS TAHU YANG DIFERMENTASI DENGAN RAGI TAPE UNTUK MENINGKATKAN PERTUMBUHAN DAN KELANGSUNGAN HIDUP BENIH IKAN LELE DUMBO (Clarias Gariepinus)." Gema Wiralodra 9, no. 2 (2018): 202–13. http://dx.doi.org/10.31943/gemawiralodra.vol9.iss2.353.
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Feed is a major factor to note for the growth of Dumbo Catfish (Clarias gariepinus). The fermentation process will simplify the particles of feed ingredients, thus increasing their nutritional value. Feed materials that have been fermented will be better quality than raw materials. Fermentation of tofu waste with yeast will convert the protein into amino acids, and indirectly will decrease the crude fiber content of tofu pulp. The method used is Experiment Method. The research was designed using Completely Randomized Design (RAL), which consisted of 3 treatments 3 replications ie the treatment of feeding dregs of fermented tofu with 1% yeast tape, the tofu fermented tofu feed was fermented with 3% tagi yeast, the fermented tofu feed fermented with 5% yeast tape. The result of calculation by using Completely Random Design and Variable Fingerprint Analysis (ANOVA), obtained from F arithmetic <F table (0,05) that is 0,29 <5,14. This shows that it is not significantly different or the same, then it is not followed by the test of the Smallest Real Beda (BNT). H0 accepted, because the results showed that there is no difference in the use of tofu fermented leaf with tape yeast on the growth and survival of Dumbo catfish (Clarias gariepinus). The survival of dumbo catfish seeds during the study was 97.78% in all treatments. Water quality during the study was within a reasonable range for the growth and survival of dumbo catfish (Clarias gariepinus).
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Meng, Yitong, and Jinlong Fei. "Hidden Service Website Response Fingerprinting Attacks Based on Response Time Feature." Security and Communication Networks 2020 (November 30, 2020): 1–21. http://dx.doi.org/10.1155/2020/8850472.
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It has been shown that website fingerprinting attacks are capable of destroying the anonymity of the communicator at the traffic level. This enables local attackers to infer the website contents of the encrypted traffic by using packet statistics. Previous researches on hidden service attacks tend to focus on active attacks; therefore, the reliability of attack conditions and validity of test results cannot be fully verified. Hence, it is necessary to reexamine hidden service attacks from the perspective of fingerprinting attacks. In this paper, we propose a novel Website Response Fingerprinting (WRFP) Attack based on response time feature and extremely randomized tree algorithm to analyze the hidden information of the response fingerprint. The objective is to monitor hidden service website pages, service types, and mounted servers. WRFP relies on the hidden service response fingerprinting dataset. In addition to simulated website mirroring, two different mounting modes are taken into account, the same-source server and multisource server. A total of 300,000 page instances within 30,000 domain sites are collected, and we comprehensively evaluate the classification performance of the proposed WRFP. Our results show that the TPR of webpages and server classification remain greater than 93% in the small-scale closed-world performance test, and it is capable of tolerating up to 10% fluctuations in response time. WRFP also provides a higher accuracy and computational efficiency than traditional website fingerprinting classifiers in the challenging open-world performance test. This also indicates the importance of response time feature. Our results also suggest that monitoring website types improves the judgment effect of the classifier on subpages.
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Basri, Hasan. "Enhanced Production Of Soybean Varieties Anjasmoro." Inovasi Pembangunan : Jurnal Kelitbangan 6, no. 01 (2018): 91–96. http://dx.doi.org/10.35450/jip.v6i01.59.
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Efforts to increase soybean production are constrained by soil problems. The soil in Lampung area most of the Yellow Padsolik type of soil, characterized by the minimal availability of nutrients, but for the development of soybean is still wide open, especially now the government is seeking self-sufficiency in soybean in 2019. This study aims to see the influence bokashi on soybean production of varieties of anjasmoro. The research was conducted at Lampung Agricultural Training Center, January to April 2017 using a randomized block design with 4 (four) treatments, repeated three times. ie Without Bokashi (B0), Bokashi 5 ton / ha (B1), Bokashi 7.5 ton / ha (B2), and Bokashi 10 ton / ha (B3). This study aims to determine the effect of bokasi in increasing soybean production of anjasmoro varieties. The data was processed by fingerprint and if there is difference of median value of treatment followed by the test of the Smallest Different Beda (BNT), at 5% level. The results showed that the application of bocation had no significant effect on the number of branches per plant, the number of books per plant and the number of root nodules per plant. The application of 15 ton / ha of bokasi gave seed yield per plant and per heavier plot compared with other treatments ie 13.17 g per plant and 16.64 kg per plot. Bokashi 5 ton / ha (B1), and Bocation Applications of 10 ton / ha (B2), were not significantly different, ie 11.33 g and 14.16 kg per plot respectively (equivalent to 1 , 42 ton / ha); 10.67 g and 13.52 kg per plot (equivalent to 1.35 ton / ha) 11.67 g and 14.90 kg per plot (equivalent to 1.49 ton / ha)
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Sari, Yanti Ratna, Tutik Nugrahini, and Mahdalena Mahdalena. "Pengaruh Pemberian Zat Pengatur Tumbuh Atonik Dan Media Tanam Terhadap Pembibitan Tanaman Aren Genjah (Arenga pinnata, Merr)." Agrifarm : Jurnal Ilmu Pertanian 6, no. 1 (2017): 15. http://dx.doi.org/10.24903/ajip.v6i1.3.
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The Influence of Atonic Growth Substance and Planting Media Against Aruh Genjah Plant Breeding (Arenga pinnata, Merr). This study aims to determine the effect of proper growth regulator concentration and the best planting medium for the growth of palm seedlings, as well as the effect of interaction between ZPT Atonik and planting media. This research was conducted in Sangatta Lama area of Sangatta Utara Sub-district, East Kutai Regency, with time for 5 (five) months from February to June 2016. The research design used Factorial Randomized Block Design (RAK) 4 x 4 with 3 repetition . The first factor was the administration of Atonic ZPT consisting of 4 levels: z0: without treatment, z1: Atonic ZPT 0.5 ml / 1 liter water, z2: ZPT Atonik 1 ml / 1 liter water, z3: ZPT Atonic 1.5 ml / 1 liter of water. The second factor is the comparison of planting medium consisting of 4 levels: m0: top soil, m1: top soil + sand + manure (1: 1: 1), m2: top soil + husk husk + manure (1: 1: 1 ), m3: top soil + charcoal husk + sand + manure (1: 1: 1: 1). Fingerprint analysis showed that the best effect of ZPT Atonik (Z) on the parameters of plant height was on the first month that is in the treatment of z2 (Atonic ZPT 1 ml / 1 liter water). The best comparison of planting medium (M) to plant height parameters was at month 2 and month 3 was achieved by treatment of m2 (top soil + husk husk + manure = 1: 1: 1) and m3 treatment (Top soil + + Sand + manure = 1: 1: 1: 1). Furthermore, the best treatment of leaflet parameter of month 1 was achieved by treatment of m1 (top soil + sand + manure = 1: 1: 1). The interaction of ZPT Atonik (zxm) comparison and the best planting medium to the leaf number parameter is the 1st month achieved by the z3p1 treatment (Atonic ZPT 1.5 ml / 1 liter water and top soil + sand + manure = 1: 1: 1) . Keywords: Growing Regulators, Planting Media and Aren GenjahThe Influence of Atonic Growth Substance and Planting Media Against Aruh Genjah Plant Breeding (Arenga pinnata, Merr). This study aims to determine the effect of proper growth regulator concentration and the best planting medium for the growth of palm seedlings, as well as the effect of interaction between ZPT Atonik and planting media. This research was conducted in Sangatta Lama area of Sangatta Utara Sub-district, East Kutai Regency, with time for 5 (five) months from February to June 2016. The research design used Factorial Randomized Block Design (RAK) 4 x 4 with 3 repetition . The first factor was the administration of Atonic ZPT consisting of 4 levels: z0: without treatment, z1: Atonic ZPT 0.5 ml / 1 liter water, z2: ZPT Atonik 1 ml / 1 liter water, z3: ZPT Atonic 1.5 ml / 1 liter of water. The second factor is the comparison of planting medium consisting of 4 levels: m0: top soil, m1: top soil + sand + manure (1: 1: 1), m2: top soil + husk husk + manure (1: 1: 1 ), m3: top soil + charcoal husk + sand + manure (1: 1: 1: 1). Fingerprint analysis showed that the best effect of ZPT Atonik (Z) on the parameters of plant height was on the first month that is in the treatment of z2 (Atonic ZPT 1 ml / 1 liter water). The best comparison of planting medium (M) to plant height parameters was at month 2 and month 3 was achieved by treatment of m2 (top soil + husk husk + manure = 1: 1: 1) and m3 treatment (Top soil + + Sand + manure = 1: 1: 1: 1). Furthermore, the best treatment of leaflet parameter of month 1 was achieved by treatment of m1 (top soil + sand + manure = 1: 1: 1). The interaction of ZPT Atonik (zxm) comparison and the best planting medium to the leaf number parameter is the 1st month achieved by the z3p1 treatment (Atonic ZPT 1.5 ml / 1 liter water and top soil + sand + manure = 1: 1: 1) . Keywords: Growing Regulators, Planting Media and Aren Genjah
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Marzelly, Ages Dwiga, Triana Lindriati, and Sih Yuwanti. "KARAKTERISTIK FISIK, KIMIA, DAN SENSORIS FRUIT LEATHER PISANG AMBON (Musa paradisiaca S.) DENGAN PENAMBAHAN GULA DAN KARAGENAN." JURNAL AGROTEKNOLOGI 11, no. 02 (2018): 172. http://dx.doi.org/10.19184/j-agt.v11i02.6526.
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Fruit leather is a fruit product that has been destroyed and then dried using an oven, so as to form a thin sheet that can be rolled. Fruit leather is generally a thin sheet with a thickness of 2-3 mm, 10-20% water content, plastis texture, was a consistency and a specific taste according to the type of fruit used. Ambon banana has a low pectin content that requires a gel-forming agent to produce the desired texture. One of the commonly used gelling materials is carrageenan. Carrageenan is one of the seaweed derived hydrocolloids that have the ability to form gel and can improved the texture of the product. Carrageenan in gel form must have a dehydrating compound. The common dehydrating agent is sugar. Sugar is a material that can attract water molecules that bind to carrageenan molecules, so that sugars can make a solid gel. The purpose of the study to determine the effect of additional sugar and carrageenan concentration on physical, chemical, and sensory characteristics of fruit leather of Ambon banana and to determine the amount of additional of sugar and carrageenan concentration according to sensory data to produce fruit leather with good sensory characteristics. This study used Completely Randomized Design (RAL) consisting of two factors and three replications. The first factor is the percentage of sugar consisting of 5%, 10%, and 15%. The second factor is the percentage of carrageenan consisting of 0.3%, 0.6%, and 0.9%. Tests carried out include physical characteristics (lighness, texture, tensile strength, and elongation), chemical characteristics (moisture content and ash content), as well as sensory characteristics (color, taste, aroma, texture and overall). The data obtained is processed using a fingerprint analysis analysis of variance using Minitab program V.1.7. If there is a significant difference or influence, then a tukey test on test level α ≤ 5% is used. The result of this research showed that the production of fruit leather of banana Ambon with the concentration of sugar and carrageenan added has a significantly characteristic sensory taste and texture, while no significant effect on the sensory characteristics of color, aroma, overall, physical characteristics (lightness, texture, elongation and tensile strength) and chemical characteristics (ash and water content). Determination of the best treatment in this study was found in A2B1 treatment using 10% sugar concentration and 0.3% carrageenan with a very liking assessment as follows 3% color; aroma 13%; 17% texture; 13% taste; and overall 13% with a total value of 59%.
 Keywords: caragenan, fruit leather, sugar
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HaCohen-Kerner, Yaakov, and Aharon Tayeb. "Rapid detection of similar peer-reviewed scientific papers via constant number of randomized fingerprints." Information Processing & Management 53, no. 1 (2017): 70–86. http://dx.doi.org/10.1016/j.ipm.2016.06.007.
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Galmarini, Carlos Maria, and Maximiliano Lucius. "Use of deep learning frameworks to detect super-responder and super-survivor stage IV squamous non-small-cell lung cancer (NSCLC) patients treated with a gemcitabine and cisplatin combination." Journal of Clinical Oncology 39, no. 15_suppl (2021): 1548. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1548.
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1548 Background: Synthetic fingerprints integrate clinical data within computational models allowing the identification of particular clinical subpopulations at a given moment. We here describe a deep learning strategy to detect super-responder and super-survivor patients with squamous NSCLC by setting up synthetic fingerprints and using unsupervised deep learning frameworks (UDLF). Methods: Through www.projectdatasphere.org, we accessed the control arm clinical data (N = 548) of the randomised phase III SQUIRE trial (NCT00981058). This trial included patients with stage IV squamous NSCLC who had not received previous chemotherapy. These patients were treated with gemcitabine 1,250 mg/m2 (IV, 30-min infusion, d1/d8) and cisplatin 75 mg/m2 (IV, 120 min infusion, d1) on a 3-week cycle for a maximum of six cycles. Synthetic fingerprints resulted of the integration of 180 features collected during the first 3 cycles including demographics, medical history, physical exam, concomitant medication, histopathology, PK parameters, adverse events and common labs. These fingerprints were used as input for the UDLF. The resultant clusters were correlated with overall-response rate (ORR) and overall survival (OS). Results: After missing data removal and feature standardization, 192 patients were eligible for the study. The UDLF was able to generate two different clusters: P0 (n = 107) and P1 (n = 84). ORR was higher in the P1 than in the P0 cluster (mean 41.6% [95% CI 31.7-52.3] vs. 28.0% [95% CI 20.4-37.2]; p = 0.04). OS was significantly longer in the P1 than in the P0 cluster (median 13.2 months vs. 9.7 months; hazard ratio 1.56 [95% CI 1.12-2.17; p = 0.008]). Feature contribution analysis showed that P1 had more patients and more events of grade III/IV neutropenia. In contrast, P0 had more patients and more events of grade III/IV nausea and vomiting. Other major differences were observed on vital signs (SBP, DBP, HR, RR, Temp), concomitant medication (osmotically-active laxatives, dexamethasone, furosemide, granisetron and ondansetron) and in hematological (RBC, HGB, HCT, MCV, WBC, neutrophils, monocytes, lymphocytes) and biochemistry (albumin, globulins, ALP, LDH, creatinine, BUN, urea, sodium, magnesium and phosphate) tests. Conclusions: Our findings show that synthetic fingerprints and subsequent deep learning analysis can be of use to identify patients with clinical characteristics associated with high-response rate and long-term survival.
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Weinert, Nicole, Remo Meincke, Christine Gottwald, et al. "Rhizosphere Communities of Genetically Modified Zeaxanthin-Accumulating Potato Plants and Their Parent Cultivar Differ Less than Those of Different Potato Cultivars." Applied and Environmental Microbiology 75, no. 12 (2009): 3859–65. http://dx.doi.org/10.1128/aem.00414-09.
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ABSTRACT The effects of genetically modified (GM), zeaxanthin-accumulating potato plants on microbial communities in the rhizosphere were compared to the effects of different potato cultivars. Two GM lines and their parental cultivar, as well as four other potato cultivars, were grown in randomized field plots at two sites and in different years. Rhizosphere samples were taken at three developmental stages during plant growth and analyzed using denaturing gradient gel electrophoresis (DGGE) fingerprints of Bacteria, Actinobacteria, Alpha- and Betaproteobacteria, Bacillus, Streptomycetaceae, Pseudomonas, gacA, Fungi, and Ascomycetes. In the bacterial DGGE gels analyzed, significant differences between the parental cultivar and the two GM lines were detected mainly for Actinobacteria but also for Betaproteobacteria and Streptomycetaceae, yet these differences occurred only at one site and in one year. Significant differences occurred more frequently for Fungi, especially Ascomycetes, than for bacteria. When all seven plant genotypes were compared, DGGE analysis revealed that different cultivars had a greater effect on both bacterial and fungal communities than genetic modification. The effects of genetic modification were detected mostly at the senescence developmental stage of the plants. The site was the overriding factor affecting microbial community structure compared to the plant genotype. In general, the fingerprints of the two GM lines were more similar to that of the parental cultivar, and the differences observed did not exceed natural cultivar-dependent variability.
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Giné, Xavier, Jessica Goldberg, and Dean Yang. "Credit Market Consequences of Improved Personal Identification: Field Experimental Evidence from Malawi." American Economic Review 102, no. 6 (2012): 2923–54. http://dx.doi.org/10.1257/aer.102.6.2923.
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We implemented a randomized field experiment in Malawi examining borrower responses to being fingerprinted when applying for loans. This intervention improved the lender's ability to implement dynamic repayment incentives, allowing it to withhold future loans from past defaulters while rewarding good borrowers with better loan terms. As predicted by a simple model, fingerprinting led to substantially higher repayment rates for borrowers with the highest ex ante default risk, but had no effect for the rest of the borrowers. We provide unique evidence that this improvement in repayment rates is accompanied by behaviors consistent with less adverse selection and lower moral hazard. (JEL D14, D82, G21, O12, O16)
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Tudaryati, Lia Agturani, Febi Nurilmala, and Krisna Dwiharniati. "UJI KETAHANAN TIGA VARIETAS TOMAT (SOLANUM LYCOPERSICUM L.) TERHADAP SERANGAN CMV (CUCUMBER MOSAIC VIRUS) DENGAN METODE DAS-ELISA." Jurnal Sains Natural 1, no. 2 (2017): 101. http://dx.doi.org/10.31938/jsn.v1i2.18.
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Endurance Test Three Tomato Variety (Solanum lycopersicum L.) Against Attacks CMV (Cucumber Mosaic Virus) DAS-ELISA Method Tomato plantation intensification can be done by controlling nuisance organism plant causes disease in tomato, such as CMV. CMV can be transmitted mechanically, and therefore testing of tomato varieties resistance to CMV can be performed with CMV isolates infect mechanically to healthy tomato plants (variety Marta F1, San Marino, and Viccario). CMV isolates derived from two sources, namely a positive tomato plants attacked by CMV (plant sap) and the positive control CMV AGDIA producers commonly used as a positive control test DAS-ELISA (Double Antibody Sandwich-Enzyme Linked immunosorbent assay). This study aims to test three varieties of tomato resistance against CMV attacks. Research conducted in the screen house and laboratory virology Central Agricultural Quarantine Standards Test. Identification of CMV infection was done by observing the incubation period, symptoms appeared, and continued with DAS-ELISA test. Structured treatment completely randomized design (CRD) with 6 replications. Data processed with fingerprint analysis and continued with various multiple Duncan test at 5% level test. The results showed the disease symptoms appeared only on the varieties of San Marino from CMV infected plant sap. Symptoms caused a reduction of leaf rolling and leaf lamina 8-10 day incubation period and symptoms of stunted stems with 14-28 day incubation period, the San Marino CMV causes the reduction of plant height by 33%. Sensitivity of tomato varieties against CMV San Marino sap from plants was quantitatively evidenced by positive results on the DAS-ELISA test. Meanwhile, F1 and Marta varieties resistant to Viccario CMV infection sap from plants and the positive control CMV AGDIA producers. Keywords : Tomato (Solanum Lycopersicum l.), Cucumber Mosaic Virus, DAS-ELISA method ABSTRAK Intensifikasi perkebunan tomat dapat dilakukan dengan mengendalikan organisme pengganggu tanaman (OPT) penyebab penyakit pada tomat, seperti CMV. CMV dapat ditularkan secara mekanis, oleh karena itu pengujian ketahanan varietas tomat terhadap CMV dapat dilakukan dengan menularkan isolat CMV secara mekanik kepada tanaman tomat sehat (varietas Marta F1, San Marino, dan Viccario). Isolat CMV berasal dari dua sumber, yaitu tanaman tomat yang positif terserang CMV (sap tanaman) dan kontrol positif CMV produsen AGDIA yang biasa digunakan sebagai kontrol positif pengujian DAS-ELISA (Double Antibody Sandwich-Enzyme Linked Immunosorbent assay). Penelitian ini bertujuan untuk menguji ketahanan tiga varietas tomat terhadap serangan CMV. Penelitian dilaksanakan di screen house dan laboratorium virologi Balai Besar Uji Standar Karantina Pertanian pada bulan Januari sampai April 2008. Identifikasi hasil penularan CMV dilakukan dengan mengamati periode inkubasi, gejala yang muncul, dan dilanjutkan dengan pengujian DAS-ELISA. Perlakuan disusun dengan rancangan acak lengkap (RAL) dengan 6 ulangan. Data diolah dengan analisis sidik ragam dan dilanjutkan dengan uji berganda Duncan pada taraf uji 5%. Hasil penelitian menunjukkan gejala penyakit hanya muncul pada varietas San Marino yang ditulari CMV asal sap tanaman. Gejala yang ditimbulkan berupa daun menggulung dan reduksi lamina daun dengan masa inkubasi 8-10 hari, serta gejala batang kerdil dengan masa inkubasi 14-28 hari, CMV pada San Marino menyebabkan reduksi tinggi tanaman sebesar 33%. Kesensitifan tomat varietas San Marino terhadap CMV asal sap tanaman secara kuantitatif dibuktikan dengan hasil yang positif pada pengujian DAS-ELISA. Sedangkan, varietas Marta F1 dan Viccario tahan terhadap penularan CMV asal sap tanaman maupun kontrol positif CMV produsen AGDIA.Kata kunci : Tomat (Solanum lycopersicum L.), Cucumber Mosaic Virus, metode DAS-ELISA
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Ullmark, Gösta, Jens Sörensen, Enn Maripuu, and Olle Nilsson. "Fingerprint pattern of bone mineralisation on cemented and uncemented femoral stems: analysis by [18F]-fluoride-PET in a randomised clinical trial." HIP International 29, no. 6 (2018): 609–17. http://dx.doi.org/10.1177/1120700018815404.
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Purpose: We present a randomised clinical study using 18F-fluoride positron emission tomography/computed tomography (F-PET/CT) to analyse the osteoblastic part of bone metabolism (new bone mineralisation) in periprosthetic bone adjacent to femoral stems following total hip arthoplasty (THA) surgery. Patients with hip osteoarthritis were randomly assigned to THA surgery with cemented or uncemented femoral components. Patients and methods: THA was performed on 26 patients (26 cases) with hip osteoarthritis. The patients received either an uncemented HA-coated femoral stem or a cemented one. The contralateral healthy femur was used as referent for normal bone metabolism. The patients were analysed with clinical score, radiography and F-PET/CT preoperatively, and postoperatively at 6 weeks and 6 months. After 2 years, clinical score and radiography was analysed again. We used the Polar Map system for analysing and presenting the PET results in 13 regions of interest adjacent to the whole stem. Results: The clinical results were good in all patients; there were no major complications. Radiographically, all stems were stable. PET analyses after 6 weeks showed that bone mineralising activity was significantly higher around the uncemented stems, both compared to the cemented group and to the contralateral healthy reference femur group. The cemented group also had elevated activity but only at a barely significant level. Interpretation: Mineralising activity analysed with F-PET/CT was significantly higher for the uncemented group and also decreased at a slower rate. F-PET/CT is a useful new tool for analysing secondary stabilisation of femoral stems after THA. The study was registered at ClinicalTrials.gov (identifier NCT01623687).
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Hallgren, Filip, Martin Stenlo, Anna Niroomand, et al. "Particle flow rate from the airways as fingerprint diagnostics in mechanical ventilation in the intensive care unit: a randomised controlled study." ERJ Open Research 7, no. 3 (2021): 00961–2020. http://dx.doi.org/10.1183/23120541.00961-2020.
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IntroductionMechanical ventilation can be monitored by analysing particles in exhaled air as measured by particle flow rate (PFR). This could be a potential method of detecting ventilator-induced lung injury (VILI) before changes in conventional parameters can be detected. The aim of this study was to investigate PFR during different ventilation modes in patients without lung pathology.MethodA prospective study was conducted on patients on mechanical ventilation in the cardiothoracic intensive care unit (ICU). A PExA 2.0 device was connected to the expiratory limb on the ventilator for continuous measurement of PFR in 30 patients randomised to either volume-controlled ventilation (VCV) or pressure-controlled ventilation (PCV) for 30 min including a recruitment manoeuvre. PFR measurements were continued as the patients were transitioned to pressure-regulated volume control (PRVC) and then pressure support ventilation (PSV) until extubation.ResultsPRVC resulted in significantly lower PFR, while those on PSV had the highest PFR. The distribution of particles differed significantly between the different ventilation modes.ConclusionsMeasuring PFR is safe after cardiac surgery in the ICU and may constitute a novel method of continuously monitoring the small airways in real time. A low PFR during mechanical ventilation may correlate to a gentle ventilation strategy. PFR increases as the patient transitions from controlled mechanical ventilation to autonomous breathing, which most likely occurs as recruitment by the diaphragm opens up more distal airways. Different ventilation modes resulted in unique particle patterns and could be used as a fingerprint for the different ventilation modes.
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Bukhari, Shazia Anwer, Nabila Farah, Saqib Mahmood, Javaria Altaf, and Ghulam Mustafa. "Effects of Seed Priming with Zinc Sulfate on Nutritional Enrichment and Biochemical Fingerprints of Momordica charantia." Journal of Food Quality 2021 (May 25, 2021): 1–13. http://dx.doi.org/10.1155/2021/5553278.
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Zinc is an essential element for plant growth and development as it plays an important role in various metabolic processes with nutritional enrichment. The treatment with zinc sulfate is also economic. Momordica charantia is an economically important medicinal plant reported for a range of pharmaceutical and pharmacological properties. In this study, nutripriming with zinc sulfate (0.1%, 0.2%, and 0.3% solution) was applied to M. charantia seeds to optimize better dose. Based upon seedling establishment, 0.3% zinc sulfate was selected for final field experiment with randomized complete block design (RCBD) with five replications. Improved germination percentage, vigor, total soluble sugars, chlorophyll-a, chlorophyll-b, total chlorophyll content, and peroxidase activity were observed variably in leaves, fruit, and peel. Other nutritive components showed maintenance in fruits of treated plants indicating that the treatment did not cause any nutritive loss. Antimicrobial activity of leaves (in terms of the minimum inhibitory concentration) against Staphylococcus aureus and Pseudomonas aeruginosa was positively correlated with sinapic acid, vanillic acid, cinnamic acid, syringic acid, chlorogenic acid, benzoic acid, and ferulic acid. It has been concluded from this study that seed priming with zinc sulfate can improve seedling establishment, photosynthetic pigments, and stable nutritive value. Therefore, zinc from zinc sulfate priming has been proved as a beneficial fertilizer for M. charantia plant growth, yield, and nutraceutical potential.
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Jayaprakasan, Kannamannadiar, Amarin Narkwichean, Walid E. Maalouf, and Bruce K. Campbell. "Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol." BMJ Open 4, no. 10 (2014): e005767. http://dx.doi.org/10.1136/bmjopen-2014-005767.
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IntroductionDehydroepiandrosterone (DHEA) has been proposed to improve pregnancy rates in women with diminished ovarian reserve undergoing in vitro fertilisation (IVF) treatment. However, evidence regarding its efficacy is supported by a limited number of randomised controlled trials (RCTs). This double-blinded RCT aims to measure the effect of DHEA supplementation prior to and during controlled ovarian hyperstimulation on ovarian response prior to IVF treatment in women predicted to have poor ovarian reserve.Methods and analysisSixty women with ovarian antral follicle count ≤10 and serum anti-Mullerian hormone ≤5 pmol/L undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment at the Nurture fertility clinic, Nottingham will be recruited. They will be randomised to either receive DHEA capsule 75 mg/day or placebo for at least 12 weeks before egg collection. All participants will undergo standard long down regulation protocol using human menopausal gonadotropin 300 IU/day. Serum samples and follicular fluids at the time of egg collection will be collected for hormonal immunoassays. For ICSI participants, cumulus cells stripped from oocyte will be collected for cumulus gene expression analyses regarding oocyte competence. Microdrops of oocyte culture media before the time of ICSI will be assessed for glucose, pyruvate and lactate utilisation. Embryo transfer will be performed on day 2, 3 or 5 based on the number and quality of the embryos available. Pregnancy will be defined as urine pregnancy test positive (biochemical pregnancy) and 6–8 weeks ultrasound scan with fetal heart beat (clinical pregnancy) and live birth. It is planned to perform the molecular and nutritional fingerprint analyses in batches after finishing the clinical phase of the study.Ethics and disseminationThe approval of the study was granted by the NHS Research Ethics Committee (Ref number NRES 12/EM/0002), the Medicines and Healthcare products Regulatory Agency (MHRA), and the Nottingham University Hospitals Trust Research and Development department. All participants shall provide written informed consent before being randomised into allocated treatment groups.Trial registration numberProtocol V.2.0; EudraCT number: 2011-002425-21; http://www.clinicaltrials.gov; NCT01572025; CTA reference: 03057/0053/001-0002
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FU, QI, ELIZABETH BENT, JAMES BORNEMAN, MAREK CHROBAK, and NEAL E. YOUNG. "ALGORITHMIC APPROACHES TO SELECTING CONTROL CLONES IN DNA ARRAY HYBRIDIZATION EXPERIMENTS." Journal of Bioinformatics and Computational Biology 05, no. 04 (2007): 937–61. http://dx.doi.org/10.1142/s0219720007002977.
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We study the problem of selecting control clones in DNA array hybridization experiments. The problem arises in the OFRG method for analyzing microbial communities. The OFRG method performs classification of rRNA gene clones using binary fingerprints created from a series of hybridization experiments, where each experiment consists of hybridizing a collection of arrayed clones with a single oligonucleotide probe. This experiment produces analog signals, one for each clone, which then need to be classified, that is, converted into binary values 1 and 0 that represent hybridization and non-hybridization events. In addition to the sample rRNA gene clones, the array contains a number of control clones needed to calibrate the classification procedure of the hybridization signals. These control clones must be selected with care to optimize the classification process. We formulate this as a combinatorial optimization problem called Balanced Covering. We prove that the problem is ℕℙ-hard, and we show some results on hardness of approximation. We propose approximation algorithms based on randomized rounding, and we show that, with high probability, our algorithms approximate well the optimum solution. The experimental results confirm that the algorithms find high quality control clones. The algorithms have been implemented and are publicly available as part of the software package called CloneTools.
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Paiva, Bruno, David Martínez-Cuadron, Juan Miguel Miguel Bergua Burgues, et al. "Role of Measurable Residual Disease (MRD) in Redefining Complete Response (CR) in Elderly Patients with Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial." Blood 132, Supplement 1 (2018): 433. http://dx.doi.org/10.1182/blood-2018-99-113299.
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Abstract Background: Incidence of AML is highest among the elderly and the general outcome is poor as compared to young patients, even those who tolerate intensive induction chemotherapy and achieve morphological CR. However, the role of MRD in redefining CR in elderly AML remains poorly investigated due to the reluctance to treat them with intensive chemotherapy, the renewed interest in low-intensity therapy such as hypomethylating agents (HMA), and the lack of molecular MRD markers in most patients. Aim: To help defining the role of MRD assessment by multidimensional flow cytometry (MFC) and therapeutic decision making in older AML patients treated with semi-intensive chemotherapy vs HMA. Methods: A total of 285 AML patients (excluding APL) with a median age of 75 were included in the phase III PETHEMA-FLUGAZA clinical trial and were randomized to receive 3 induction cycles with fludarabine and cytarabine (FLUGA) followed by 6 consolidation cycles with reduced intensity FLUGA, vs 3 induction cycles with 5-azacitidine (AZA) followed by 6 consolidation cycles with AZA. After consolidation, patients continued with the same treatment if MRD ≥0.01% or stopped if MRD <0.01%. MRD was prospectively assessed after induction and consolidation among patients in CR with or without incomplete blood count recovery, in a central laboratory blinded for clinical outcomes. At diagnosis, the EuroFlow panel for MDS/AML (first-five 8-color combinations) was used to identify leukemia-associated immunophenotypes (LAIP). Patients without a LAIP (6%) were excluded from this analysis. At CR, bone marrow samples were immunophenotyped with ≥2 8-color combinations based on previously identified maturation arrest, lineage commitment and LAIPs, maintaining markers' position from diagnosis to MRD to provide a digital fingerprint of leukemic blasts at diagnosis during MRD assessment. Over 1 million events per tube were measured for assessing MRD with an estimated sensitivity of 0.01%. The cumulative incidence of relapse (CIR) was calculated from the date of CR to the date of relapse, considering death without relapse as a competing event. Results: On intention-to-treat, 38/141 (27%) patients achieved CR after 3 cycles of FLUGA, and 31/144 (21.5%) after 3 cycles of AZA (P =.33). Among patients in CR with previously identified LAIP, 14/69 (20%) achieved a negative MRD status whereas the remaining 55 (80%) had persisting MRD: 56% with ≥0.1% MRD and 24% with 0.01%-0.09% MRD. Of note, negative MRD rates were particularly lower among AML patients with myelodysplasia-related changes as compared to other subtypes (11% vs 27%, respectively; P=.09). Regarding the effect of semi-intensive chemotherapy vs HMA on depth of response, we observed a non-significant trend toward higher MRD-negative rates among patients in CR after FLUGA vs those treated with AZA (26% vs 15%, respectively; P=.28). The 2-year CIR rates for MRD-positive and MRD-negative patients were 88% and 47%, respectively (HR, 3.3; P =.001). Of note, the CIR of patients in CR but with persistent MRD were similarly poor as compared to those in partial remission (HR, 0.82; P =.48). Furthermore, MRD-positive patients with adverse cytogenetics displayed the poorest outcome with significantly higher 2-year CIR rates than MRD-positive cases with intermediate/favorable cytogenetics (HR, 2.1; P =.008). Interestingly, among patients in CR and persistent MRD, 2-year CIR rates showed a non-significant trend towards slightly more frequent relapses in those treated with FLUGA vs AZA (91% vs 77%, respectively; HR, 1.7; P =.09). On multivariable analysis for CIR including MFC-MRD and cytogenetics, MFC-MRD (HR, 3.6; P =.001) and cytogenetics (HR, 2.0; P =.007) retained significant prognostic value. The median overall survival (OS) for MRD-positive and MRD-negative patients was 17 and 29 months, respectively (P =.04). On multivariable analyses for OS including age, WBC count, cytogenetic grouping and secondary disease, persistent MRD showed a trend for independent prognostic value (HR, 2.4; P =.07). Conclusions: This study reveals that sensitive MFC-MRD assessment supersedes CR and is an independent prognostic factor in older patients with AML, treated with semi-intensive chemotherapy or HMA. Nevertheless, the risk of relapse among the few patients with no MRD (5%) remains high after stopping treatment, and warrants innovative approaches aimed at maintaining an MRD-negative CR status. Disclosures San-Miguel: Janssen: Honoraria; BMS: Honoraria; Novartis: Honoraria; Celgene: Honoraria; Amgen: Honoraria; Sanofi: Honoraria; Roche: Honoraria. Montesinos:Novartis: Research Funding, Speakers Bureau; Daiichi Sankyo: Consultancy, Speakers Bureau.
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McAuley, Sybil A., Melissa H. Lee, Barbora Paldus, et al. "Six Months of Hybrid Closed-Loop Versus Manual Insulin Delivery With Fingerprick Blood Glucose Monitoring in Adults With Type 1 Diabetes: A Randomized, Controlled Trial." Diabetes Care 43, no. 12 (2020): 3024–33. http://dx.doi.org/10.2337/dc20-1447.
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Berg, Gabriele, Nicolle Roskot, Anette Steidle, Leo Eberl, Angela Zock, and Kornelia Smalla. "Plant-Dependent Genotypic and Phenotypic Diversity of Antagonistic Rhizobacteria Isolated from Different Verticillium Host Plants." Applied and Environmental Microbiology 68, no. 7 (2002): 3328–38. http://dx.doi.org/10.1128/aem.68.7.3328-3338.2002.
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ABSTRACT To study the effect of plant species on the abundance and diversity of bacterial antagonists, the abundance, the phenotypic diversity, and the genotypic diversity of rhizobacteria isolated from potato, oilseed rape, and strawberry and from bulk soil which showed antagonistic activity towards the soilborne pathogen Verticillium dahliae Kleb. were analyzed. Rhizosphere and soil samples were taken five times over two growing seasons in 1998 and 1999 from a randomized field trial. Bacterial isolates were obtained after plating on R2A (Difco, Detroit, Mich.) or enrichment in microtiter plates containing high-molecular-weight substrates followed by plating on R2A. A total of 5,854 bacteria isolated from the rhizosphere of strawberry, potato, or oilseed rape or bulk soil from fallow were screened by dual testing for in vitro antagonism towards Verticillium. The proportion of isolates with antagonistic activity was highest for strawberry rhizosphere (9.5%), followed by oilseed rape (6.3%), potato (3.7%), and soil (3.3%). The 331 Verticillium antagonists were identified by their fatty acid methyl ester profiles. They were characterized by testing their in vitro antagonism against other pathogenic fungi; their glucanolytic, chitinolytic, and proteolytic activities; and their BOX-PCR fingerprints. The abundance and composition of Verticillium antagonists was plant species dependent. A rather high proportion of antagonists from the strawberry rhizosphere was identified as Pseudomonas putida B (69%), while antagonists belonging to the Enterobacteriaceae (Serratia spp., Pantoea agglomerans) were mainly isolated from the rhizosphere of oilseed rape. For P. putida A and B plant-specific genotypes were observed, suggesting that these bacteria were specifically enriched in each rhizosphere.
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Perakakis, Nikolaos, Konstantinos Stefanakis, Michael Feigh, Sanne S. Veidal, and Christos S. Mantzoros. "Both Elafibranor and Liraglutide Improve NAFLD / NASH but Affect Differentially the Hepatic Lipidome and Metabolome in a Diet-Induced Obese and Biopsy-Confirmed Mouse Model of NASH." Journal of the Endocrine Society 5, Supplement_1 (2021): A314—A315. http://dx.doi.org/10.1210/jendso/bvab048.642.
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Abstract Treatment of Nonalcoholic fatty liver disease (NAFLD) constitutes an unmet clinical need owing to the relatively limited efficacy of both novel and readily available metabolic medications, thus warranting pathobiological investigations on the mechanisms of single or combination regimens. In this context, our study aimed to assess and compare whether and how liraglutide, a glucagon-like peptide-1 receptor agonist, and elafibranor, a dual peroxisome proliferator-activated receptor alpha-delta agonist, may affect hepatic histology and metabolipidomic fingerprints in a model of advanced NAFLD. Male C57BL/6JRj mice with biopsy-confirmed hepatosteatosis and fibrosis induced by AMLN diet (40% fat with 20% trans-fat, 2% cholesterol and 22% fructose) were randomized to receive for 12 weeks: a) Liraglutide (0.4 mg/kg/d s.c.), b) Elafibranor (30 mg/kg/d p.o.), c) vehicle. Metabolic indices, liver function markers, liver pathology, and metabolomics/lipidomics were assessed at study completion. Both drugs markedly reduced body weight and fat percentage (p-value &lt;0.001), and improved glucose tolerance and insulin sensitivity, as indicated by oral glucose and intraperitoneal insulin tolerance tests. Hepatic lipid content was downregulated under both treatments (p-value &lt;0.001), especially under elafibranor, which also elevated liver weight in contrast with liraglutide (p-value vs liraglutide &lt;0.001). NAFLD activity score (pre-to-post) and its histological components were substantially improved (mean difference ± standard error of mean: -1.4 ± 0.3 for liraglutide; -2.0 ± 0.2 for elafibranor), with elafibranor demonstrating a more robust anti-steatotic effect vs liralgutide (p-value &lt;0.01) as well as anti-fibrotic effects (-0.5 ± 0.1). Liraglutide also limited the immunohistochemical expression of pro-inflammatory markers of Kupffer and hepatic stellate cell function (Galectin-3, Collagen type I alpha 1, and alpha-smooth muscle actin). In the omics analysis, elafibranor profoundly ameliorated the hepatic lipidome by diminishing the concentrations of glyceride species, increasing phospholipids and carnitine metabolites, and modifying key regulators of fatty acid oxidation, inflammation, and oxidative stress, including metabolites of methionine, glutathione, and pantothenate. Liraglutide significantly affected bile acid and carbohydrate metabolism by restoring the concentrations of metabolically beneficial primary and secondary bile acids, glycogen metabolism by-products, and pentoses, thus probably driving glycogen utilization-turnover and nucleic acid synthesis. Thus, liraglutide and elafibranor diverge in their mechanistic treatment of advanced NAFLD pathology, indicated by their robust but differential regulation of the hepatic metabolipidome. These findings support their combinatory therapeutic evaluation in future studies.
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Galmarini, Carlos Maria, and Maximiliano Lucius. "Predicting disease progression and mortality in metastatic colorectal cancer patients (mCRC) through an artificial intelligence-based analytical tool." Journal of Clinical Oncology 39, no. 15_suppl (2021): 1549. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1549.
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1549 Background: Predicting the clinical course of metastatic disease remains a key challenge in CRC. Estimating prognosis of these late-stage patients can avoid undertreatment or overtreatment and also guide the follow-up intensity. This study has investigated the ability of an artificial intelligence-based analytical tool to identify those mCRC patients with high risk of disease progression and mortality based on their clinical parameters. Methods: Through www.projectdatasphere.org we accessed datasets of two randomised phase III trials including chemo-naïve (NCT00364013, n = 1183 patients) and chemo-refractory (NCT00113763, N = 483) mCRC patients. We generated synthetic fingerprints (SF) for each patient through the integration of 44 clinical features (demographics, anthropometrics, medical history, blood tests and treatment characteristics) collected, respectively, during the screening phase and the first month of inclusion in each trial. These SF were then input into a deep learning framework (DLF) to identify subgroup of patients based on their similarities. The resultant clusters were correlated with progression-free survival (PFS) and overall survival (OS). Results: After discarding missing data, 861 chemo-naïve and 341 chemo-resistant mCRC patients were eligible for the study. In the chemo-naïve cohort, the SF/DLF system was able to detect two different clusters: C0 (n = 31) and C1 (n = 830). Patients in C0 had a higher risk of progression (median PFS 6.2 months vs. 9.1 months; hazard ratio 1.83, 95% CI 1.16-2.88; p = 0.008) and death (median OS 13.2 months vs. 20.1 months; hazard ratio 2.84, 95% CI 1.68-4.80; p < 0.001) compared to patients in C1. When applied to the chemo-resistant cohort, the SF/DLF system was again able to identify two different clusters: P0 (n = 159) and P1 (n = 182). Patients in P0 had a higher risk of progression (median PFS 1.7 months vs. 1.8 months; hazard ratio 1.32, 95% CI 1.05-1.67; p < 0.001) and death (median OS 6.1 months vs. 6.8 months; hazard ratio 1.34, 95% CI 1.07-1.68; p = 0.01) compared to patients in P1. In both cases, feature contribution analysis showed that major differences between clusters were related to clinical status, anthropometrics and haematological and biochemistry tests. Conclusions: Our SF/DLF system can identify mCRC subtypes based on distinct clinical features that correlate with higher risk of progression and death. Further work is required to validate this approach as a novel prognostic biomarker tool for monitoring mCRC patients.
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Samaha, Ghada M., M. A. Ahmed, and Asmaa R. Abd El-Hameid. "Assessment of growth and productivity of five peanut cultivars and genetic diversity using RAPD markers." Bulletin of the National Research Centre 43, no. 1 (2019). http://dx.doi.org/10.1186/s42269-019-0201-z.
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Abstract Background This study was conducted to evaluate the genetic diversity of five peanut cultivars grown under field conditions. A field experiment was conducted using five peanut cultivars (Giza-5, Giza-6, Ismailia-1, Gregory, and R92) in a randomized complete block design with five replications during two following seasons to estimate the performance of five peanut cultivars for vegetative growth, yield, and yield component traits as well as seed quality traits. Twenty RAPD primers were used to identify a unique fingerprint for each of five cultivars. Results Giza-6 cultivar surpassed all the tested peanut cultivars in the most vegetative growth traits and yield and its components traits, while the lowest values were observed in Giza-5 cultivar. The dendrogram constructed from RAPD analysis showed that Gregory and Giza-5 were the most distant among five peanut cultivars. Conclusions RAPD markers are useful in the detection of genetic diversity of peanut. The availability of genetic diversity is important for the genetic improvement of peanut.
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Packel, Laura, Carolyn Fahey, Atuganile Kalinjila, Agatha Mnyippembe, Prosper Njau, and Sandra I. McCoy. "Preparing a financial incentive program to improve retention in HIV care and viral suppression for scale: using an implementation science framework to evaluate an mHealth system in Tanzania." Implementation Science Communications 2, no. 1 (2021). http://dx.doi.org/10.1186/s43058-021-00214-w.
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Abstract Background Viral suppression is key to ending the HIV epidemic, yet only 58% of people living with HIV (PLHIV) in sub-Saharan Africa are suppressed. Cash transfers are an effective strategy to improve retention in care, but little is known about optimization of implementation; for example, designing effective programs that integrate into existing clinic workflows. We studied implementation of an mHealth system to deliver cash transfers to support retention. Methods We conducted a mixed-methods study assessing implementation of an mHealth cash transfer study. This was part of a larger, hybrid implementation-effectiveness randomized controlled trial evaluating cash transfers conditional on visit attendance for viral suppression among Tanzanian PLHIV initiating ART. An mHealth system using fingerprint identification and mobile payments was used to automatically disburse mobile money to eligible PLHIV. We used Proctor’s framework, assessing implementation of the mHealth system from the perspectives of PLHIV and clinicians. We analyzed mHealth system data and conducted surveys (n = 530) and in-depth interviews (n = 25) with PLHIV, clinic and pharmacy staff (n = 10), and structured clinic observations (n = 2293 visits). Results One thousand six hundred fifty-one cash transfers were delivered to 346 PLHIV in the cash arms, 78% through mobile money. Among those in the cash arms, 81% registered their mobile money account with the mHealth system by study end, signaling high adoption. While acceptability for fingerprinting and mobile payments was high among PLHIV, interviews revealed mixed views: some had privacy concerns while others felt the system was secure and accurate, and provided some legitimacy to the clinical visits. Pharmacists praised system efficiency, but concerns about duplicative recordkeeping and added work arose. Clinic staff voiced excitement for the system’s potential to bring the cash program to all patients and simplify workflows; yet concerns about multiple systems, staffing, and intermittent connectivity tempered enthusiasm, highlighting structural issues beyond program scope. Structured observations revealed a steep learning curve; repeat fingerprint scans and manual entry declined as the system improved. Conclusions Biometric identification and mobile payments were acceptable to most patients and staff. Fingerprinting encountered some feasibility limitations in the first months of testing; however, mobile payments were highly successful. Biometric identification and mobile payments may provide a scalable mechanism to improve patient tracking and efficiently implement financial incentives in low-resource settings. Trial registration Name of the registry: clinicaltrials.gov Trial registration number: NCT03351556 Date of registration: 11/24/2017 Checklists: StaRI (included with submission). Note CONSORT for cluster-randomized trials was used for the main trial but is not directly applicable to this manuscript.
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Hasim, Hasim, Mulis Mulis, and Basman B. Indak. "Spora Growth Gracillaria sp in Different Salinities." JURNAL SUMBERDAYA AKUATIK INDOPASIFIK, November 6, 2019, 81. http://dx.doi.org/10.46252/jsai-fpik-unipa.2019.vol.3.no.2.71.
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The demand for Gracillaria commodities continues to increase for food, medicines, and beauty ingredients. These conditions encourage the cultivation of this commodity continues to proliferate. Because of that, availability of Gracillaria sp seeds is available both in quantity and quality. One effort that can be done in handling the Gracillaria sp spores through environmental engineering. One such factor is fisheries salinity. The difference in salinity supports the increase in Gracillaria spores so that it affects spore growth. The aim of the study was to study the growth of Gracillaria spores cultured on different salinity media. The method used is a laboratory experiment method with a completely randomized trial design (CRD) with forty salinity preparations (23 ppt, 26 ppt, 29 ppt, and 32 ppt) and is repeated three times. The resulting data were then analyzed by analysis of variance. The results showed the highest spore growth at 23 ppt salinity with the number of spores (560.9 Ind / cm2), then 26 ppt salinity (438.8 Ind / cm2), then 32 ppt salinity (429.9 Ind / cm2) and low in salinity 29 with the number of spores (277.8 Ind / cm2). Fingerprint analysis showed that each evaluation results were not significantly different.
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Bustami, Yazidul, Ratna Ratna, and Bambang Sukarno Putra. "Pengaruh Kemasan Dan Absorber Terhadap Umur Simpan Buah Pisang Ayan (Musa Acuminata)." Jurnal Ilmiah Mahasiswa Pertanian 2, no. 4 (2017). http://dx.doi.org/10.17969/jimfp.v2i4.5495.
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Abstrak. Bahan yang digunakan adalah plastik polipropilen, polietilen dan pisang barangan yang diporoleh dari petani di Sare Aceh Besar. Umur panen 100 hari-120 hari setelah pembungaan. Penelitian menggunakan menggunakan Rancangan Acak Lengkap (RAL). Perlakuan yang dilakukan pada penelitian ini adalah perlakuan kemasan Polipropilen (P1), Polietilen (P2), dan dengan perlakuan pemberian silika gel (A1) dan arang sekam padi (A2) pada setiap kemasan. Perlakuan ini dilakukan sebanyak 3 kali ulangan. Sehingga terdapat 12 satuan percobaan. Hasil penelitian diperoleh Susut bobot berkisar antara 0,32% nilai tersebut didapat selama 15 hari penyimpanan. Tingkat kekerasan berkisar antara 3,15-2,03 Kg/cm2. Nilai kadar air berkisar antara 68,67-75,89%, anoalisis sidik ragam menunjukkan bahwa kombinasi perlakuan silika gel dan arang sekam berpengaruh nyata terhadap kadar air pisang. Nilai TPT meningkat berkisar antara 18,07-7,50%.Utilization Packaging And Shelf Life Absorber Against Chicken Banana (Musa Acuminata)Abstract. The materials used are polypropylene, polyethylene and banana plastic from farmers in Sare Aceh Besar. Harvest age 100 days-120 days after flowering. The study used using Completely Randomized Design (RAL). The treatments were Polypropylene (P1), Polyethylene (P2), and by treatment of silica gel (A1) and rice husk charcoal (A2) on each package. This treatment is done as much as 3 times repetition. So there are 12 experimental units. The result of this research is weight loss ranging from 0,32% the value obtained for 15 days storage. The level of hardness ranges from 3.15 to 2.03 Kg / cm2. The value of water content ranged from 68,67-75,89%, fingerprint anoalysis showed that combination of treatment of silica gel and charcoal husk significantly affected banana water content. The value of TPT increased between 18.07-7.50%.
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Li, Li, Na Ning, Jian-an Wei, et al. "Metabonomics Study on the Infertility Treated With Zishen Yutai Pills Combined With In Vitro Fertilization-embryo Transfer." Frontiers in Pharmacology 12 (July 19, 2021). http://dx.doi.org/10.3389/fphar.2021.686133.
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Zishen Yutai Pills (ZYP) is a safe and well quality-controlled TCM preparation with promising effects in many fields of reproduction, including prevention of miscarriage, increase of pregnancy rate during in vitro fertilization-embryo transfer (IVF-ET). The plasma of patients was collected from a clinical trial, namely, “Effect of Traditional Chinese Medicine vs placebo on live births among women undergoing in vitro fertilization, a multi-center randomized controlled trial.” Plasma samples were analyzed with metabonomics method. UPLC-MS technology was used to establish the plasma metabolic fingerprint. Multivariate statistical analysis was applied for comparing the differences of plasma metabolites between ZYP group and placebo group, 44 potential metabolites were screen out and identified. Pathway analysis was conducted with database mining. Compared with placebo, chemicals were found to be significantly down-regulated on HCG trigger day and 14 days after embryo transplantation, including trihexosylceramide (d18:1/26:1), glucosylceramide(d18:1/26:0), TG(22:6/15:0/22:6), TG(22:4/20:4/18:4). Compared with placebo, some chemicals were found to be significantly up-regulated on HCG trigger day and 14 days after embryo transplantation, i.e., PIP3(16:0/16:1), PIP2(18:1/18:1), tauroursodeoxycholic acid, L-asparagine, L-glutamic acid, kynurenic acid, 11-deoxycorticosterone, melatonin glucuronide, hydroxytyrosol. These metabolites were highly enriched in pathways including sphingolipid metabolism, alanine, aspartic acid and glutamic acid metabolism, aminoacyl tRNA biosynthesis, taurine and hypotaurine metabolism. This study revealed metabolic differences between subjects administered with ZYP and placebo. Relating metabolites were identified and pathways were enriched, providing basis on the exploration on the underlying mechanisms of ZYP combined with IVF-ET in the treatment of infertility.
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Ivey, Kerry L., Eric B. Rimm, Peter Kraft, et al. "Identifying the metabolomic fingerprint of high and low flavonoid consumers." Journal of Nutritional Science 6 (2017). http://dx.doi.org/10.1017/jns.2017.27.
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AbstractHigh flavonoid consumption can improve vascular health. Exploring flavonoid–metabolome relationships in population-based settings is challenging, as: (i) there are numerous confounders of the flavonoid–metabolome relationship; and (ii) the set of dependent metabolite variables are inter-related, highly variable and multidimensional. The Metabolite Fingerprint Score has been developed as a means of approaching such data. This study aims to compare its performance with that of more traditional methods, in identifying the metabolomic fingerprint of high and low flavonoid consumers. This study did not aim to identify biomarkers of intake, but rather to explore how systemic metabolism differs in high and low flavonoid consumers. Using liquid chromatography–tandem MS, 174 circulating plasma metabolites were profiled in 584 men and women who had complete flavonoid intake assessment. Participants were randomised to one of two datasets: (a) training dataset, to determine the models for the discrimination variables (n 399); and (b) validation dataset, to test the capacity of the variables to differentiate higher from lower total flavonoid consumers (n 185). The stepwise and full canonical variables did not discriminate in the validation dataset. The Metabolite Fingerprint Score successfully identified a unique pattern of metabolites that discriminated high from low flavonoid consumers in the validation dataset in a multivariate-adjusted setting, and provides insight into the relationship of flavonoids with systemic lipid metabolism. Given increasing use of metabolomics data in dietary association studies, and the difficulty in validating findings using untargeted metabolomics, this paper is of timely importance to the field of nutrition. However, further validation studies are required.
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Hapsoh, Wawan, Isna Rahma Dini, and Devi Andriani. "Biofertilizer Formulation with Bioactivators Bacillus cereus on the Growth and Yeild of Upland Rice (Oryza sativa L.) in Peat Medium." Asian Journal of Applied Sciences 9, no. 3 (2021). http://dx.doi.org/10.24203/ajas.v9i3.6666.
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This study aims to test the bio-fertilizer formulation with Bacillus cereus bioactivator and to obtain the best bio-fertilizer formulation for the growth and yield of upland rice (Oryza sativa L.) in peat medium. The research was conducted in the experimental garden and Soil Science Laboratory, Faculty of Agriculture, University of Riau from July to October 2018. The study was carried out experimentally using a completely randomized design (RAL) with the treatment tested was the formulation of Bacillus cereus (F): F0: 100 ml Bacillus cereus without formulation, F1: 100 ml Bacillus cereus inoculant+74% bagasse+13% dolomite+13% zeolite, F2: 100 ml Bacillus cereus inoculant+74% rice husk+13% zeolite+13% dolomite, F3: 100 ml inoculant Bacillus cereus+74% solid+13% dolomite+13% zeolite, F4: 100 ml Bacillus cereus inoculant+74% tkks+13% zeolite+13% dolomite. The data obtained were analyzed statistically using variance fingerprints. The average result of the analysis was continued with the BNJ test at the 5% level. The results showed that administration of Bacillus cereus without formulation and with the formulation of solid organic matter of rice husks, solids and oil palm empty bunches showed a good response to the amount of chlorophyll and yield of upland rice plants.
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Mosley, Philip E., François Windels, John Morris, et al. "A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder." Translational Psychiatry 11, no. 1 (2021). http://dx.doi.org/10.1038/s41398-021-01307-9.
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AbstractDeep brain stimulation (DBS) is a promising treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with DBS electrodes bilaterally in the bed nucleus of the stria terminalis (BNST). Following a one-month postoperative recovery phase, participants entered a three-month randomised, double-blind, sham-controlled phase before a twelve-month period of open-label stimulation incorporating a course of cognitive behavioural therapy (CBT). The primary outcome measure was OCD symptoms as rated with the Yale-Brown Obsessive-Compulsive Scale (YBOCS). In the blinded phase, there was a significant benefit of active stimulation over sham (p = 0.025, mean difference 4.9 points). After the open phase, the mean reduction in YBOCS was 16.6 ± 1.9 points (χ2 (11) = 39.8, p = 3.8 × 10−5), with seven participants classified as responders. CBT resulted in an additive YBOCS reduction of 4.8 ± 3.9 points (p = 0.011). There were two serious adverse events related to the DBS device, the most severe of which was an infection during the open phase necessitating device explantation. There were no serious psychiatric adverse events related to stimulation. An analysis of the structural connectivity of each participant’s individualised stimulation field isolated right-hemispheric fibres associated with YBOCS reduction. These included subcortical tracts incorporating the amygdala, hippocampus and stria terminalis, in addition to cortical regions in the ventrolateral and ventromedial prefrontal cortex, parahippocampal, parietal and extrastriate visual cortex. In conclusion, this study provides further evidence supporting the efficacy and tolerability of DBS in the region of the BNST for individuals with otherwise treatment-refractory OCD and identifies a connectivity fingerprint associated with clinical benefit.
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Ranasinghe, R. L. D. S., R. H. S. K. De Silva, L. D. A. M. Arawwawala, and H. G. S. G. Wijesiriwardhana. "Phytochemical Variation of a Poly-herbal Formula According to Its Preparation Method: Qualitative & Quantitative Analysis." Journal of Complementary and Alternative Medical Research, February 26, 2020, 22–28. http://dx.doi.org/10.9734/jocamr/2020/v9i130133.
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Madhyama Rasnadi decoction, one of the poly-herbal decoctions used in Ayurveda medicine is especially indicated for inflammatory conditions. The literature provides three different preparation methods of this decoction viz; Sri Lankan Traditional method (Method 1) and methods described in the texts Sharangadhara Samhita (Method 2) and Bhaishajya Ratnavali (Method 3). The aim of this study was to analyse and compare the phytochemical profiles of these three preparation techniques. Phytochemical profile analysis was carried out by (i) investigation of the extractable matter in 1 ml of decoction, (ii) development of Thin Layer Chromatography profiles and (iii) qualitative/quantitative determination of major phytoconstituents. Results revealed that the extractable matter of methods 1, 2 and 3 was 310±0 mg/ml, 420±0 mg/ml and 180±0 mg/ml, respectively. Differences (in terms of the number of spots and intensity) were observed in TLC fingerprint profiles, and phytochemicals such as phenols, tannins, flavonoids, saponins, alkaloids and terpenoids were present in all three types of decoctions. Gallic acid and quercetin were taken as standards to express the results of polyphenolic and flavonoid contents, respectively. Total polyphenolic contents of decoctions prepared according to methods 1, 2 and 3 were 121.68±0.60, 178.40±0.56, 86.20±0.25 mg gallic acid equivalents/g extract respectively. Total flavonoid contents of decoctions prepared according to methods 1, 2 and 3 were 69.45± 0.80, 129.30±0.65, 52.64± 0.50 mg quercetin acid equivalents/g extract respectively. In conclusion, more phytochemicals are concentrated on the decoction that made of method 2. The study opens more vistas of clinical applicability of Madhyama Rasnadi decoction, where further randomised case-control studies are needed.