Thematische Bibliographien / Qiqihaer zhong xue xiao

Auswahl der wissenschaftlichen Literatur zum Thema „Qiqihaer zhong xue xiao“

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Veröffentlicht am 25. Juli 2024

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Zeitschriftenartikel zum Thema "Qiqihaer zhong xue xiao"

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Yeung, Bryan K., Xiao Hui Koh, Wei Li Ling, Weiqi Tan, You Xue Wu, Xi Yun Zhang, Hong Yee Tan, Shao Jun Liu, Chen Zhong und Bin Zou. „Abstract 3137: Development of AT2604, a highly efficacious ADC targeting alkaline phosphatases ALPP and ALPPL2​“. Cancer Research 84, Nr. 6_Supplement (22.03.2024): 3137. http://dx.doi.org/10.1158/1538-7445.am2024-3137.

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Abstract Placental alkaline phosphatases, ALPP and ALPPL2, are highly homologous, membrane-bound proteins involved in fetal development. Despite having limited expression in normal tissues, they are highly differentiated in tumor cells making them ideal targets for antibody drug conjugate (ADC) development. AT2604 is an ADC that consists of a humanized IgG1 anti-ALPP/ALPPL2 antibody that displays specificity over other human alkaline phosphatases and is cross reactive to NHP ALPPL2 but not to murine ALPPL2. The anti-ALPP/ALPPL2 antibody shows high target binding affinity and internalization into ALPP and ALPPL2 positive cells.​ AT2604 utilizes AxcynCYSTM technology for site-specific conjugation to achieve a highly homogeneous (>97%) DAR4 ADC product. The payload is the clinically validated microtubule disrupting agent monomethyl auristatin E (MMAE) conjugated to the antibody via a protease-cleavable peptide linker approved for ADC use. When evaluated in mouse xenograft models of gastric (NCI-N87) and pancreatic (HPAC) cancer, AT2604 displayed strong tumor growth inhibition (>90%) at 1 mg/kg (QW3 × 2 dosing) in both models. Furthermore, a pre-tox study in non-human primates concluded AT2604 has a HNSTD of 10 mg/kg (QW3 × 3 dosing) and did not exhibit any non-reversible adverse effects; implying that AT2604 possesses an improved safety profile over other vedotin-based ADCs. Taken together, the data supports the continued development of AT2604 towards evaluation in human trials.​ Citation Format: Bryan K. Yeung, Xiao Hui Koh, Wei Li Ling, Weiqi Tan, You Xue Wu, Xi Yun Zhang, Hong Yee Tan, Shao Jun Liu, Chen Zhong, Bin Zou. Development of AT2604, a highly efficacious ADC targeting alkaline phosphatases ALPP and ALPPL2​ [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3137.
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Yao, Qi, Bo-tao Chang, Rong Chen, Yi-jing Wei, Qiu-ju Gong, Dan Yu, Yang Zhang et al. „Research Advances in Pharmacology, Safety, and Clinical Applications of Yunnan Baiyao, a Traditional Chinese Medicine Formula“. Frontiers in Pharmacology 12 (24.11.2021). http://dx.doi.org/10.3389/fphar.2021.773185.

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Ethnopharmacology relevance: Yunnan Baiyao (YNBY), a traditional Chinese medicine formulae, has some significant properties including activating blood circulation to dissipate blood stasis (Huo-Xue-Hua-Yu), eliminating swelling and alleviating pain (Xiao-Zhong-Zhi-Tong), and eliminating necrotic tissues and promoting granulation (Qu-Fu-Sheng-Ji).Aim of this study: This paper intends to provide a comprehensive and critical analysis of studies on YNBY, proposing new possible therapeutic directions of this formula.Materials and methods: Relevant data on YNBY were retrieved from available databases and a hand-search by searching the keywords such as “Yunnan Baiyao,” “pharmacology,” “toxicity,” and “clinical applications.”Results: Traditionally, YNBY has been used to cure hemorrhage, bruises, swelling, and pain caused by injuries in the Chinese folk. Modern pharmacological studies show that YNBY possesses pharmacological activities including hemostasis, invigorating the circulation of blood, wound healing, anti-inflammation, analgesia, antibiosis, infection prevention, and other effects. Toxicological studies demonstrate that YNBY has a certain toxicology, which is mainly caused by Aconitum alkaloids from Cao-wu (CW, Aconiti Kusnezoffii Radix). The developmental non-toxic reaction dose (NOAEL) of YNBY for embryos and fetuses is 0.5 g/kg in rats. In addition, the NOAEL for fertility and early embryo development toxicity is 4.0 g/kg in rats. Clinical trials have confirmed the safety of YNBY in a large number of patients, and adverse drug reactions (ADRs) such as abdominal pain, diarrhea, allergy, and others in very few people. YNBY is routinely used in clinic to cure bleeding, pain, swelling, upper digestive tract ulcer, postoperative wound, arthritis, mouth ulcers, ulcerative colitis, etc.Conclusions: Hemostasis is a conspicuous effect of YNBY. Except for this effect, analgesia and anti-infection may be new research directions of this formula. In addition, the in vitro and in vivo pharmacology and mechanisms of action of YNBY are encouraged as well as the pharmacokinetics of this formulae. Furthermore, the material basis of the pharmacological effects of YNBY also needs clear identification.
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Dissertationen zum Thema "Qiqihaer zhong xue xiao"

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Huang, Songliang. „Bian ge zhong de xue xiao ling dao Xianggang "ai guo xue xiao" de ge an yan jiu /“. online access from Digital Dissertation Consortium, 2006. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?3254535.

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Cheung, Po-chu. „Teaching and evaluation of Intensive Characters Recognition Learning Program of S.1 band-5 students in Hong Kong Xianggang di wu zu bie xue xiao zhong yi xue sheng ji zhong shi zi jiao xue ji ping gu /“. Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31960054.

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Chan, Yuen-nga. „Yun yong pian zhang jie gou ce lüe ti sheng zhong san xue sheng yue du shuo ming wen de cheng xiao“. Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4255374X.

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Chan, Kok-chi. „Effectiveness of computer-assisted learning in Chinese language Dian nao fu zhu zhong wen yue du jiao xue zhi cheng xiao ping gu /“. Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31959969.

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Chou, Kam-ngan. „The learning of Chinese lexicon by providing primary one pupils with essential learning experiences Kuo kuo xiao yi xue sheng de xue xi jing li yi ti sheng zhong wen ci hui liang /“. Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37642935.

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Chan, Kung Fong. „Cong jiao yu zhong "gai zao" nü xing : yi "Guangdong Sheng li di yi nü zi shi fan xue xiao" wei ge an yan jiu (1907-1938) /“. View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202004%20CHAN.

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Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2004.
Includes bibliographical references (leaves 323-342). Also available in electronic version. Access restricted to campus users.
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Chan, Lai-wa, und 陳麗華. „The investigation of the effectiveness of process writing method to enhance the practical writing ability of international school students who learn Chinese as a second language = Guo cheng xie zuo jiao xue fa dui ti sheng guo ji xue xiao Zhong wen wei di er yu yan xue sheng xie zuo ying yong wen zhi cheng xiao yan jiu“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209681.

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Wong, Yan-nar. „The development of Chinese writing curriculum in primary school in Hong Kong, 1975-1990 Xianggang xiao xue Zhong wen xie zuo ke cheng de fa zhan (1975-1990) /“. Click to view the E-thesis via HKUTO, 1996. http://sunzi.lib.hku.hk/hkuto/record/B31959118.

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Cheng, Mei-yi, und 鄭美儀. „The development of story writing in Chinese of Hong Kong primary school students = Xianggang xiao xue sheng de Zhong wen gu shi xie zuo neng li fa zhan“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/209120.

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This study aimed to explore Hong Kong primary school students’ development of story writing in Chinese, by examining the fluency, structure and organization ability, and communication ability. It was a basic research that adopted qualitative and quantitative research methodologies. In total, 2823 pieces of Chinese story writing were collected from three Hong Kong primary schools; 1200 samples were randomly selected for analysis in details. In analysing the selected samples, the total numbers of words and sentences were first identified. Then, the type of structural organization with reference to story schema, and their communication elements were studied. Finally, the data were used for additional statistical analysis. The study showed that primary school students’ ability in writing Chinese stories was developmental and with variety of ability within each class level. The fluency, structure and organization ability, and communication ability were gradually improved when students got older. This study has four major findings. First, the total numbers of words and sentences were increased at each grade level. Difference in the total numbers of words and sentences within the same class level was significantly found in Primary Four and difference became larger in Primary Five and Six. Second, the story schema which students constructed in their story writing was more and more complex as they grew up. Third, the older subject students could write much more rich contents in the beginning and ending of story. Fourth, the older subject students were more skilled at using the communication elements in the beginning of story, and expressing major theme through the story writing. The study’s results enrich the understanding of the theories of the language development of children and their story writing. It also provides valuable information for the researchers in the related areas, and the teachers who teach Chinese and design Chinese writing curriculum. However, this study is only an exploratory attempt to study Hong Kong primary school students’ development of story writing in Chinese; further verification of its findings and test are needed. 本研究旨在探討三所香港小學生的中文故事寫作能力發展。研究是一項基礎研究，採用質性和量性的研究方法，分析研究對象中文故事寫作的流暢性、結構組織能力和傳意能力。本研究從三所小學搜集了2823篇中文故事寫作研究樣本，再以隨機抽樣的方式抽取1200篇作為分析之用。最後，對所得的數據會進行統計分析，以了解研究對象的中文故事寫作能力發展。 研究結果顯示，研究對象的中文故事寫作能力具發展性和差異性，會隨?年級的增長，在流暢性、結構組織能力和傳意能力方面的表現會有所提升。流暢性方面，研究對象寫作的「總字數」和「總句數」均隨?年級逐年的上升而穩步增加，而各級研究對象的表現均有明顯的差異，並在小四年級開始擴大。結構組織能力方面，研究對象在中文故事寫作中應用的故事結構圖式，隨?年級的增長而趨於複雜。按研究對象的故事結構組織能力，大致上可以把他們分成三段發展階段。第一組為小一和小二，第二組為小三和小四，第三組為小五和小六。研究對象的開端鋪敘能力和故事結構組織能力一樣，大致可以分為三段發展階段。結尾鋪敘能力方面，亦是隨?年級的增長而鋪敘更多的故事內容。不過，敘述觀點卻沒有呈現發展的趨勢。傳意能力方面，研究對象雖然會隨?年級的增長，更能在故事的開端部份加入傳意元素，但能夠在中文故事寫作的開端部份加入傳意元素的研究對象不多，而且較多集中在高年級。至於透過故事寫作傳達主題思想方面，小三至小六年級中，明顯有較多研究對象能夠在中文故事寫作中傳遞主題思想。 本研究探討了三所小學生的中文故事寫作能力發展，研究的結果豐富了兒童語言發展和故事寫作理論，亦為進行相關研究的學者，以及規劃中國語文寫作課程或教學的教師，提供了有價值的資料。不過，本研究是一項初步的探索性研究，所取得的發現有待進一步證實和發展。
published_or_final_version
Education
Doctoral
Doctor of Philosophy
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To, Suk-kwan. „The effectiveness of a reading module in enhancing junior students' reading motivation and conceptual knowledge Ti sheng chu zhong xue sheng yue du dong ji ji wen hua zhi shi dan yuan jiao xue cheng xiao yan jiu /“. Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B40039985.

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Bücher zum Thema "Qiqihaer zhong xue xiao"

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Zhao, Shu, und Yupu Liu. He ming jiu gao shui run fang hua: Xiao zhi (1952-2012). [Qiqihaer Shi]: [Qiqihaer Shi di san zhong xue], 2012.

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lin, Xue bao. Qiqihaer shi fan gao deng zhuan ke xue xiao xiao zhi (1906-2006). 8. Aufl. [Qiqihaer Shi: Qiqihaer shi fan gao deng zhuan ke xue xiao], 2006.

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Wu, Wenbo. Baoji zhong xue xiao zhi. 8. Aufl. [Baoji: Baoji zhong xue xiao zhi bian zuan wei yuan hui], 2010.

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Shanxi Sheng Fengxiang zhong xue. Fengxiang zhong xue xiao zhi. [Fengxiang Xian: Shanxi Sheng Fengxiang zhong xue, 1988.

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Ji, Shiwu, und Junyi Zhang. Zizhou zhong xue xiao zhi. 8. Aufl. [Zizhou Xian: Shanxi Sheng Zizhou zhong xue xiao zhi bian xie ling dao xiao zu], 2004.

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Bingying, Xie. Zhong xue sheng xiao shuo. [Beijing: Beijing zhong xian tuo fang ke ji fa zhan you xian gong si, 2012.

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Ji, Xianlin. Wo de xiao xue he zhong xue. 8. Aufl. Beijing Shi: Wai yu jiao xue yu yan jiu chu ban she, 2009.

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mi, Mai ke de. Xue zhong zhi xian. 8. Aufl. Nan ning: Guang xi ren min chu ban she, 2012.

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Shenyang Shi jiao yu zhi bian xie ban gong shi. Shenyang Shi zhong xiao xue shi fan xue xiao jian jie, 1985: Shen yang Shi zhong xiao xue shi fan xue xiao jian jie, 1985. Shenyang Shi: Shenyang Shi jiao yu zhi bian xie ban gong shi, 1988.

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Lin, Shu. Shi fan xue xiao zhong xue xiao xiu shen jiang yi. [Beijing: Beijing zhong xian tuo fang ke ji fa zhan you xian gong si, 2012.

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