Thematische Bibliographien / Psača

Auswahl der wissenschaftlichen Literatur zum Thema „Psača“

Autor: Grafiati
Veröffentlicht am 26. Juli 2024
Zuletzt aktualisiert am 26. Juli 2024

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Zeitschriftenartikel zum Thema "Psača"

1

Gor, Dennis O., Xuedong Ding, Qing Li, John R. Schreiber, Michael Dubinsky und Neil S. Greenspan. „Enhanced Immunogenicity of Pneumococcal Surface Adhesin A by Genetic Fusion to Cytokines and Evaluation of Protective Immunity in Mice“. Infection and Immunity 70, Nr. 10 (Oktober 2002): 5589–95. http://dx.doi.org/10.1128/iai.70.10.5589-5595.2002.

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ABSTRACT Immunization of mice with pneumococcal surface adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against systemic infection with Streptococcus pneumoniae. Because the use of CFA is not acceptable in humans, we sought to develop alternative means of enhancing the immunogenicity of protein antigens of potential use in pneumococcal vaccines. We designed a series of genetic constructs in which coding sequences for PsaA were linked to sequences encoding either murine interleukin-2 (mIL-2), mIL-4, or two copies of an immunostimulatory nonapeptide derived from mIL-1β. The PsaA-cytokine constructs were cloned and expressed in Escherichia coli. Mice immunized twice with PsaA-IL-2, or PsaA-IL-4 responded with PsaA-specific antibody production comparable in magnitude to that of mice primed with PsaA in CFA and boosted with PsaA in incomplete Freund's adjuvant (PsaA-Adj). Antibodies elicited by PsaA-Adj were predominantly of the immunoglobulin G1 (IgG1) subclass, while PsaA-IL-2 and PsaA-IL-4 elicited substantial amounts of IgG2a in addition to IgG1. Mice immunized with PsaA-Adj or PsaA-IL-4 were partially protected against intraperitoneal challenge with virulent S. pneumoniae (30% overall survival beyond 15 days postchallenge). Mice immunized with PsaA and no adjuvant or PsaA-IL-2 exhibited 0 or 5% survival rates, respectively, following challenge. In contrast, mice immunized twice with capsular polysaccharide were 100% protected. The modest levels of protection seen in mice immunized with PsaA and its more immunogenic derivatives may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of encapsulated S. pneumoniae.
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2

Sommer, Frederik, Friedel Drepper, Wolfgang Haehnel und Michael Hippler. „The Hydrophobic Recognition Site Formed by Residues PsaA-Trp651and PsaB-Trp627of Photosystem I inChlamydomonas reinhardtiiConfers Distinct Selectivity for Binding of Plastocyanin and Cytochromec6“. Journal of Biological Chemistry 279, Nr. 19 (02.03.2004): 20009–17. http://dx.doi.org/10.1074/jbc.m313986200.

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On the lumenal side of photosystem I (PSI), each of the two large core subunits, PsaA and PsaB, expose a conserved tryptophan residue to the surface. PsaB-Trp627is part of the hydrophobic recognition site that is essential for tight binding of the two electron donors plastocyanin and cytochromec6to the donor side of PSI (Sommer, F., Drepper, F., and Hippler, M. (2002)J. Biol. Chem.277, 6573–6581). To examine the function of PsaA-Trp651in binding and electron transfer of both donors to PSI, we generated the mutants PsaA-W651F and PsaA-W651S by site-directed mutagenesis and biolistic transformation ofChlamydomonas reinhardtii.The protein-protein interaction and the electron transfer between the donors and PSI isolated from the mutants were analyzed by flash absorption spectroscopy. The mutation PsaA-W651F completely abolished the formation of a first order electron transfer complex between plastocyanin (pc) and the altered PSI and increased the dissociation constant for binding of cytochrome (cyt)c6by more than a factor of 10 as compared with wild type. Mutation of PsaA-Trp651to Ser had an even larger impact on the dissociation constant. TheKDvalue increased another 2-fold when the values obtained for the interaction and electron transfer between cytc6and PSI from PsaA-W651S and PsaA-W651F are compared. In contrast, binding and electron transfer of pc to PSI from PsaA-W651S improved as compared with PSI from PsaA-W651F and admitted the formation of an inter-molecular electron transfer complex, resulting in aKDvalue of about 554 μmthat is still five times higher than observed for wild type. These results demonstrate that PsaA-Trp651is, such as PsaB-Trp627, crucial for high affinity binding of pc and cytc6to PSI. Our results also indicate that the highly conserved structural recognition motif that is formed by PsaA-Trp651and PsaB-Trp627confers a differential selectivity in binding of both donors to PSI.
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Ataman-Duruel, E. Tuğba, Onurcem Duruel, Ilser Turkyilmaz und Tolga F. Tözüm. „Anatomic Variation of Posterior Superior Alveolar Artery: Review of Literature and Case Introduction“. Journal of Oral Implantology 45, Nr. 1 (01.02.2019): 79–85. http://dx.doi.org/10.1563/aaid-joi-d-18-00056.

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The objective of this article is to review topography of posterior superior alveolar artery (PSAA), and to present a case with visualization of a rare anatomic variation of PSAA. An electronic search was undertaken to identify articles about topography of PSAA in Medline, Embase, and Google Scholar databases, published between January 1977 and December 2017. Two animal studies, 8 cadaver studies, 18 cone-beam computerized tomography (CBCT) studies, and 2 review articles were found. The animal studies, cadaver studies, and review articles were excluded because they were not about topography of PSAA. Only CBCT studies were included in this review. Accurate knowledge of vital structures in the surgical area is critical during surgical procedures. PSAA should be analyzed during planning sinus lifting with lateral approach. In the present case, a detailed evaluation of patient by CBCT provided the opportunity to find out a rare variation of PSAA with multiple vessels.
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Huang, Xiao-Zhe, und Luther E. Lindler. „The pH 6 Antigen Is an Antiphagocytic Factor Produced by Yersinia pestis Independent of Yersinia Outer Proteins and Capsule Antigen“. Infection and Immunity 72, Nr. 12 (Dezember 2004): 7212–19. http://dx.doi.org/10.1128/iai.72.12.7212-7219.2004.

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ABSTRACT The pH 6 antigen (pH 6 Ag; PsaA) of Yersinia pestis has been shown to be a virulence factor. In this study, we set out to investigate the possible function of Y. pestis PsaA in a host cell line, RAW264.7 mouse macrophages, in order to better understand the role it might play in virulence. Y. pestis KIM5 derivatives with and without the pCD1 plasmid and their psaA isogenic counterparts and Escherichia coli HB101 and DΗ5α carrying a psaA clone or a vector control were used for macrophage infections. Macrophage-related bacteria and gentamicin-resistant intracellular bacteria generated from plate counting and direct microscopic examinations were used to evaluate these RAW264.7 macrophage infections. Y. pestis psaA isogenic strains did not show any significant difference in their abilities to associate with or bind to mouse macrophage cells. However, expression of psaA appeared to significantly reduce phagocytosis of both Y. pestis and E. coli by mouse macrophages (P < 0.05). Furthermore, we found that complementation of psaA mutant Y. pestis strains could completely restore the ability of the bacteria to resist phagocytosis. Fluorescence microscopy following differential labeling of intracellular and extracellular Y. pestis revealed that significantly lower numbers of psaA-expressing bacteria were located inside the macrophages. Enhanced phagocytosis resistance was specific for bacteria expressing psaA and did not influence the ability of the macrophages to engulf other bacteria. Our data demonstrate that Y. pestis pH 6 Ag does not enhance adhesion to mouse macrophages but rather promotes resistance to phagocytosis.
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Fitriani, Indah. „PERAN PERPUSTAKAAN MINI DI TENGAH PANDEMI COVID-19 BAGI ANAK-ANAK PANTI SOSIAL ASUHAN ANAK (PSAA) TUNAS MELATI BANDUNG“. Dharmakarya 11, Nr. 3 (29.11.2022): 245. http://dx.doi.org/10.24198/dharmakarya.v11i3.31784.

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Penulisan artikel PKM ini bertujuan untuk tetap berkontribusi kepada masyarakat, khususnya bagi anak-anak di Panti Sosial Asuhan Anak (PSAA) Tunas Melati, di tengah pandemi Covid-19 dengan cara pengadaan perpustakaan mini. Sebelum penyebaran Covid 19, kegiatan PKM di Panti Sosial Asuhan Anak (PSAA) Tunas Melati sudah pernah dilaksanakan. Namun, dengan adanya Pembatasan Sosial Berskala Besar (PSBB) di Bandung, kegiatan PKM lanjutan di PSAA Tunas Melati pun tidak dapat dilakukan secara tatap muka langsung. Oleh karena itu, agar tetap dapat berkontribusi terhadap PSAA Tunas Melati, maka kegiatan PKM pun dilakukan dengan cara mengirimkan buku-buku dan rak-rak buku yang dapat digunakan untuk membuat perpustakaan mini di panti tersebut. Mengenai bagaimana peran perpustakaan mini bagi anak-anak PSAA Tunas Melati Bandung, melalui metode kuesioner dengan penyajian hasil melalui deskriptif analisis, kami mencoba untuk memaparkan manfaat apa saja yang dirasakan anak-anak PSAA Tunas Melati setelah adanya perpustakaan mini di tengah PSBB karena adanya pendemi Covid 19. Hasil pengamatan kami menunjukkan bahwa peran perpustakaan mini bagi anak-anak PSAA Tunas Melati adalah anak-anak dapat menghilangkan kebosanan dengan buku, anak-anak merasa mendapatkan pengalaman baru dengan membaca buku dan mereka lambat laun merasakan keakraban dengan buku dan perpustakaan.
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Romero-Steiner, Sandra, Tamar Pilishvili, Jacquelyn S. Sampson, Scott E. Johnson, Annie Stinson, George M. Carlone und Edwin W. Ades. „Inhibition of Pneumococcal Adherence to Human Nasopharyngeal Epithelial Cells by Anti-PsaA Antibodies“. Clinical Diagnostic Laboratory Immunology 10, Nr. 2 (März 2003): 246–51. http://dx.doi.org/10.1128/cdli.10.2.246-251.2003.

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ABSTRACT The role of pneumococcal (Pnc) surface adhesin A (PsaA) in the adherence of Streptococcus pneumoniae (pneumococcus) to host cells is not well defined. We examined the effect of anti-PsaA antibodies in an inhibition of adherence assay using Detroit 562 nasopharyngeal human epithelial cells. Rabbit polyclonal (Pab) anti-recombinant PsaA (rPsaA) sera, a purified mouse monoclonal antibody (MAb) (MAb 6F62G8E12), and 22 healthy adult sera with known anti-PsaA IgG levels (obtained by enzyme-linked immunosorbent assay) were evaluated for their abilities to inhibit Pnc adherence to confluent monolayers (measured as percent reduction in CFU counts compared to those of uninhibited controls). Pnc adherence was dependent on capsular phenotype (no or low adherence for opaque strains). With an inoculum of 104 to 105 bacteria/well, the mean ± standard deviation count in controls was 163 ± 32 CFU/well for transparent strains. Low adherence was observed for a PsaA-minus mutant even at higher inoculum doses. Mean percent inhibitions of adherence with Pab and MAb were 54 and 50%, respectively. Adult sera showed inhibition in a dose-response fashion with a range of 98 to 8%, depending on the serum anti-PsaA antibody concentration. Absorption of Pab with rPsaA restored Pnc adherence to control levels. Absorption of sera with a PsaA-minus mutant did not result in a significant decrease (P >0.05) of inhibition of adherence activity. Additionally, nearly 100% of Pnc adherence was inhibited by lipidated rPsaA at 2.5 μg/ml. Our data support the argument that PsaA is an adhesin that mediates Pnc adherence to human nasopharyngeal cells. This functional assay may be useful in evaluating antibodies elicited in response to PsaA vaccination.
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Tseng, Hsing-Ju, Alastair G. McEwan, James C. Paton und Michael P. Jennings. „Virulence of Streptococcus pneumoniae: PsaA Mutants Are Hypersensitive to Oxidative Stress“. Infection and Immunity 70, Nr. 3 (März 2002): 1635–39. http://dx.doi.org/10.1128/iai.70.3.1635-1639.2002.

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ABSTRACT psaA encodes a 37-kDa pneumococcal lipoprotein which is part of an ABC Mn(II) transport complex. Streptococcus pneumoniae D39 psaA mutants have previously been shown to be significantly less virulent than wild-type D39, but the mechanism underlying the attenuation has not been resolved. In this study, we have shown that psaA and psaD mutants are highly sensitive to oxidative stress, i.e., to superoxide and hydrogen peroxide, which might explain why they are less virulent than the wild-type strain. Our investigations revealed altered expression of the key oxidative-stress response enzymes superoxide dismutase and NADH oxidase in psaA and psaD mutants, suggesting that PsaA and PsaD may play important roles in the regulation of expression of oxidative-stress response enzymes and intracellular redox homeostasis.
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Poloz, Yekaterina, Andrew Catalano und Danton H. O'Day. „Bestatin Inhibits Cell Growth, Cell Division, and Spore Cell Differentiation in Dictyostelium discoideum“. Eukaryotic Cell 11, Nr. 4 (17.02.2012): 545–57. http://dx.doi.org/10.1128/ec.05311-11.

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ABSTRACTBestatin methyl ester (BME) is an inhibitor of Zn2+-binding aminopeptidases that inhibits cell proliferation and induces apoptosis in normal and cancer cells. We have usedDictyosteliumas a model organism to study the effects of BME. Only two Zn2+-binding aminopeptidases have been identified inDictyosteliumto date, puromycin-sensitive aminopeptidase A and B (PsaA and PsaB). PSA from other organisms is known to regulate cell division and differentiation. Here we show that PsaA is differentially expressed throughout growth and development ofDictyostelium, and its expression is regulated by developmental morphogens. We present evidence that BME specifically interacts with PsaA and inhibits its aminopeptidase activity. Treatment of cells with BME inhibited the rate of cell growth and the frequency of cell division in growing cells and inhibited spore cell differentiation during late development. Overexpression of PsaA-GFP (where GFP is green fluorescent protein) also inhibited spore cell differentiation but did not affect growth. Using chimeras, we have identified that nuclear versus cytoplasmic localization of PsaA affects the choice between stalk or spore cell differentiation pathway. Cells that overexpressed PsaA-GFP (primarily nuclear) differentiated into stalk cells, while cells that overexpressed PsaAΔNLS2-GFP (cytoplasmic) differentiated into spores. In conclusion, we have identified that BME inhibits cell growth, division, and differentiation inDictyosteliumlikely through inhibition of PsaA.
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lmaz, Sebiha, und Ferit Bayram. „Posterior Superior Alveolar Artery Thickness and Intraoperative Bleeding in Maxillary Sinus Floor Augmentation Procedures“. Annals of Medical Research 31, Nr. 6 (2024): 429. http://dx.doi.org/10.5455/annalsmedres.2024.01.013.

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Objective: This study aimed to investigate the relationship between the thickness of the posterior superior alveolar artery (PSAA) and the intraoperative bleeding volume during maxillary sinus floor augmentation (MSFA) procedures. Materials and Methods: This was a prospective observational study involving 24 consecutive participants who underwent MSFA at a university hospital in Turkey. The thickness of the PSAA was assessed using cone beam computed tomography (CBCT). Intraoperative data were collected to measure bleeding volume. The statistical analysis included Spearman correlation analysis to determine the relationship between PSAA thickness and bleeding volume. Results: The present study revealed no significant correlation between the thickness of the PSAA and the volume of intraoperative bleeding. The mean PSAA thickness was 1.36 mm (SD: 0.40 mm), and the widest canal diameter was 2.40 mm. Univariate analysis revealed no significant associations between PSAA diameter and the assessed factors, with β values ranging from -10.510 to 6.814 and p values all above 0.2. Conclusion: These findings suggest that the thickness of the PSAA, as determined by CBCT, may not be a predictive factor for intraoperative bleeding during MSFA procedures. This study contributes to the understanding of surgical risk management in MSFA patients and supports the continued use of CBCT for preoperative assessment.
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Guerrero-Sánchez, Yolanda, Francisco José Gómez García, Manuel Fernández-Martínez, Blanca Pallarés Martínez und Pia López-Jornet. „Anatomical Considerations and Study of the Fractal Dimension around the Posterior Superior Alveolar Artery“. Symmetry 12, Nr. 7 (16.07.2020): 1177. http://dx.doi.org/10.3390/sym12071177.

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The Posterior Superior Alveolar Artery (PSAA) provides vascular support to molars, gingiva, and maxillary sinus. A tear of the PSAA may cause profuse hemorrhages which may lead to complications at a surgical level. As such, it becomes crucial to anatomically analyse several features regarding the PSAA as well as the area surrounding it. In this paper, we are particularly interested in the study of the complexity of the periodontal tissue structure which appears close to the location of the PSAA. A total amount of 400 cone beam computed tomography (CBCT) scans (two per subject) were performed to explore the presence of the PSAA, the thickness of the Schneider’s membrane, and the existence of septa. Several parameters were evaluated including the location of the artery in the maxillary sinus, the distance from the PSAA to the alveolar ridge, the thickness of the membrane, the diameter of the cavities produced by the septa, and the fractal dimension of the trabecular tissue that surrounds the PSAA. They were found strong linear relationships between Distal and Central Measures (a Pearson’s R 2 = 0.9952 ), Mesial and Central Measures ( R 2 = 0.9950 ), and Distal and Mesial Measure ( R 2 = 0.997 ). We hypothesised that the loss of dental pieces would imply a distinct complexity of the trabecular tissue structure surrounding the PSAA. In this way, a p-value equal to 0.001 was provided by the Mann-Whitney test, which supports our hypothesis. Furthermore, the mean of the fractal dimensions of the group of edentulous patients (equal to 1.56 ) was found to be lower than the one of the group of non-edentulous patients (equal to 1.61 ) with small standard deviations in both cases. Our study suggests that accurate calculations of the fractal dimension combined with the use of CBCT do provide valuable information regarding the area that surrounds the PSAA.
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Dissertationen zum Thema "Psača"

1

Westerberg, Marcus. „Diagnosing Metastatic Prostate Cancer Using PSA:A Register-Based Cohort Study with Missing Data“. Thesis, Uppsala universitet, Tillämpad matematik och statistik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322012.

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2

Arêas, Ana Paula de Mattos. „Estudo do efeito adjuvante de CTB em fusões com as proteínas pneumocócicas PsaA e PspA no desenvolvimento de vacinas protéicas contra Streptococcus pneumoniae“. Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-16092007-181850/.

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A colonização da mucosa respiratória é a primeira etapa na patogênese de Streptococcus pneumoniae, bactéria causadora de pneumonia, meningite, e otite média, responsável por mais de um milhão de mortes por ano no mundo. As proteínas de superfície PsaA e PspA têm sido investigadas como candidatos vacinais para estas doenças. CTB é a porção não tóxica da toxina colérica (CT), responsável pela ligação da toxina ao receptor celular GM1 e descrita como adjuvante de mucosas. Neste trabalho, estes genes de S. pneumoniae foram clonados em pAE, um vetor de expressão de E. coli, que utiliza o promotor T7, ou a 3\' de ctxB no plasmídeo pAE-ctxB. As proteínas recombinantes CTB, PsaA, CTB-PsaA, PspA1, CTB-PspA1, PspA3 e CTB-PspA3 foram expressas em E. coli BL21 (SI) e purificadas através de coluna carregada com níquel. Ensaios de ligação ao receptor GM1 mostraram que CTB e a porção CTB das proteínas de fusão foram obtidas na forma funcional. Imunização por via intranasal com CTB-PsaA e, por via intranasal e intradérmica com CTB-PspA1 e CTB-PspA3 induziu a produção de IgG no soro. Em compensação, somente a imunização com a fusão CTB-PsaA induziu produção de IgA nas secreções de mucosa. Ensaios de colonização da nasofaringe de camundongos BALB/C e C57BL/6 mostraram que a imunização intranasal com CTB-PsaA resulta em diminuição de colonização por S. pneumoniae. Desafios letais com linhagem virulenta de S. pneumoniae mostraram que a imunização intradérmica com CTB-PspA3, ao contrário da imunização intranasal, é capaz de proteger os animais. Uma vez que estas proteínas de fusão induziram resposta imune protetora, estas deverão ser investigadas como componentes de uma nova vacina para infecções causadas por S. pneumoniae.
The colonization of the respiratory mucosa is the first step in the pathogenesis of Streptococcus pneumoniae, bacterium that causes pneumonia, meningitis and otitis media. It is responsible for more than one million deaths per year worldwide. The surface proteins PsaA and PspA have been investigated as vaccine candidates against these diseases. CTB is the non-toxic portion of cholera toxin (CT), responsible for the toxin binding to the cellular receptor GM1 and described as mucosal adjuvant. In this study, these genes from S. pneumoniae were cloned in pAE, an E. coli expression vector that uses T7 promoter, or downstream to ctxB gene in the pAE-ctxB plasmid. The recombinant proteins CTB, PsaA, CTB-PsaA, PspA1, CTB-PspA1, PspA3 and CTB-PspA3 were expressed in E. coli BL21 (SI) and purified through a chelating resin charged with nickel. GM1 binding assays showed that CTB and CTB portion of the fusion proteins were functional. Intranasal immunization with CTB-PsaA and, intranasal and intradermal administration of CTB-PspA1 and CTB-PspA3 induced IgG production in the serum. On the other hand, only CTB-PsaA fusion protein induced IgA in the mucosal secretions. Nasopharyngeal colonization assays in BALB/C and C57BL/6 mice showed that intranasal immunization with CTB-PsaA results in a decrease of colonization by S. pneumoniae. Lethal challenges with S. pneumoniae virulent strains indicated that intradermal immunization with CTB-PspA3, in contrast to the intranasal immunization, is able to protect mice. Since the fusion proteins induced a specific immune response, they should be further investigated as components of a new vaccine against infections caused by S. pneumoniae.
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Becerra, Martínez José Luis Elías. „Obtención de una proteína recombinante PsaA de Streptococcus pneumoniae, homóloga a una de Streptococcus equi“. Tesis, Universidad de Chile, 2005. http://repositorio.uchile.cl/handle/2250/130773.

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Memoria para optar al Título Profesional de Médico Veterinario
Los streptococos patógenos para los equinos incluyen S. equi subsp. equi (S. equi), S. equi subsp. zooepidemicus, S. dysgalactiae subsp. equisimilis y S. pneumoniae cápsula Tipo III. S. equi causa gurma, una linfoadenitis purulenta altamente contagiosa que afecta a los miembros de la familia Equidae. Rápidos progresos se han realizado para la identificación de factores de virulencia y proteínas de S. equi. La mayoría de éstas son expresadas en la superficie bacteriana o son secretadas. Se ha demostrado la presencia de una proteína homóloga a la pneumococcal surface adhesin A (PsaA) de S. pneumoniae, en S. zooepidemicus y S. equi. La PsaA de S. pneumoniae, como otras proteínas, es inmunogénica y protege animales de laboratorio ante un desafío con neumococos. El objetivo de esta memoria fue obtener desde un aislado clínico de S. pneumoniae, una PsaA recombinante purificada desde E. coli BL21DE3. La metodología consistió en amplificar el gen PsaA por PCR y ligarlo al plasmidio de clonamiento (pETBlue-1), luego con la mezcla de ligación PsaA/pSTBlue-1 se transformó la cepa E. coli DH5; de las colonias transformadas, se purificó el plasmidio (PsaA/pSTBlue-1) por lisis alcalina, el cual fue sometido a digestión doble y, el fragmento liberado, fue ligado finalmente a un vector de expresión (pET-15b). Con la mezcla de ligación PsaA/pET-15b, se transformó la cepa E. coli BL21DE3, que expresó una proteína fusionada a una cola de histidina; la proteína fusionada, a su vez, se purificó en una columna con afinidad por histidina (Ni-Nta). La presencia de rPsaA fue analizada mediante electroforesis en gel de poliacrilamida y por Western blot, observándose la presencia de una proteína de 37 kDa., con la que reaccionó específicamente el anticuerpo policlonal de conejo anti His-tag. La secuencia nucleotídica del fragmento fue comparada en la base de datos BLAST (www.ncbi.nlm.nih.gov), encontrándose un 98% de identidad con la cepa S. pneumoniae R6. Además se identificaron cuatro regiones, con identidades superiores al 80%, similares a las del gen parcial mba de la proteína ligadora de metal/adhesina de S. equi, homóloga a PsaA de S. pneumoniae. El producto obtenido permitirá realizar estudios de formulación y evaluación, en modelo animal, de un prototipo de vacuna contra el gurma, basado en la proteína PsaA de S. pneumoniae.
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Obaidullah, Ahmad J. „A ROUTE TO DISCOVER SMALL MOLECULE INHIBITORS OF PSAA, A POTENTIAL TARGET FOR STREPTOCOCCUS PNEUMONIAE“. VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3549.

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Due to the development of multidrug resistance in Streptococcus pneumoniae, research has begun to define new drug targets for pneumonia therapy. Different research groups have identified a lipoprotein, PsaA that is important for pneumonia virulence. PsaA is a manganese transporter that is required for bacterial virulence and growth. We have employed computer modeling to virtually screen a small-molecule database for inhibition of PsaA function by targeting the metal binding pocket, performing receptor-based virtual screening and molecular docking and scoring to identify potential inhibitors of PsaA function. We have developed an assay for screening compounds, including the use of a PsaA mutant, testing of multiple compounds, and identification of compounds that inhibit Streptococcus pneumoniae growth at concentrations less than 20 μM. We experimentally tested the effect on Mn uptake and their PsaA dependence for 42 compounds, but these experiments suggested that these compounds were affecting bacterial growth by a different mechanism.
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Silva, Marcelo da. „Clonagem, expressão e purificação das proteínas de superfície, PsaA e fragmentos de PspA de Streptococcus pneumoniae“. Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-27102005-163558/.

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Streptococcus pneumoniae é o principal causador da pneumonia bacteriana. As vacinas atualmente disponíveis contêm polissacarídeo capsular conjugado ou não com proteínas carreadoras. No entanto, elas apresentam elevado custo ou proteção reduzida nos grupos de risco (crianças abaixo de 5 anos de idade e idosos). Proteínas de superfície de S. pneumoniae, como a PsaA e PspA, são consideradas fortes candidatas vacinais. Com o objetivo de se desenvolver uma vacina de ampla cobertura e baixo custo contra pneumococos, os genes psaA e pspA foram clonados em vetores de expressão em E. coli, pAE e pET e as proteínas expressas foram purificadas por cromatografias de afinidade e de troca aniônica. O rendimento de proteína recombinante obtido com a construção baseada em pET foi 3 vezes maior que o obtido com pAE. Condições de cultivo foram estabelecidas utilizando meio definido com indução por IPTG e/ou por lactose. As cepas recombinantes estão adequadas para serem usadas em estudos para escalonamento da produção em biorreatores.
Streptococcus pneumoniae is the main causative agent of bacterial pneumonia. The current vaccines available contain capsular polysaccharide conjugated or not with carrier proteins. However these are either too expensive or do not protect the high-risk groups. Surface proteins of S. pneumoniae, such as PsaA and PspA, are considered strong vaccine candidates. With the aim of developing a broad-coverage and low-cost vaccine against pneumococcus, the psaA and pspA genes were cloned in E. coli expression vectors, pAE and pET and the expressed proteins were purified through affinity and anion exchange chromatography. The yield of the recombinant protein obtained with the construction based in pET was 3-fold higher than that obtained with pAE. Culture conditions were established using defined media with IPTG and/or lactose induction. The recombinant strains are now ready to undergo studies for scale-up of production in bioreactors.
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Gylle, A. Maria. „Physiological adaptations in two ecotypes of Fucus vesiculosus and in Fucus radicans with focus on salinity“. Doctoral thesis, Mittuniversitetet, Institutionen för naturvetenskap, teknik och matematik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-13308.

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The in origin intertidal marine brown alga Fucus vesiculosus L. grow permanently sublittoral in the brackish Bothnian Sea, side by side with the recently discovered F. radicans L. Bergström et L. Kautsky. Environmental conditions like salinity, light and temperature are clearly different between F. vesiculosus growth sites in the Bothnian Sea (4-5 practical salinity units, psu; part of the Baltic Sea) and the tidal Norwegian Sea (34-35 psu; part of the Atlantic Ocean). The general aims of this thesis were to compare physiological aspects between the marine ecotype and the brackish ecotype of F. vesiculosus as well as between the two Bothnian Sea species F. vesiculosus and F. radicans. The result in the study indicates a higher number of water soluble organic compounds in the marine ecotype of F. vesiculosus compared to the brackish ecotype. These compounds are suggested to be compatible solutes and be due to an intertidal and sublittoral adaptation, respectively; where the intertidal ecotype needs the compounds as a protection from oxygen radicals produced during high irradiation at low tide. The sublittoral ecotype might have lost the ability to synthesize these compound/compounds due to its habitat adaptation. The mannitol content is also higher in the marine ecotype compared to the brackish ecotype of F. vesiculosus and this is suggested to be due to both higher level of irradiance and higher salinity at the growth site. 77 K fluorescence emission spectra and immunoblotting of D1 and PsaA proteins indicate that both ecotypes of F. vesiculosus as well as F. radicans have an uneven ratio of photosystem II/photosystem I (PSII/PSI) with an overweight of PSI. The fluorescence emission spectrum of the Bothnian Sea ecotype of F. vesiculosus however, indicates a larger light-harvesting antenna of PSII compared to the marine ecotype of F. vesiculosus and F. radicans. Distinct differences in 77 K fluorescence emission spectra between the Bothnian Sea ecotype of F. vesiculosus and F. radicans confirm that this is a reliable method to use to separate these species. The marine ecotype of F. vesiculosus has a higher photosynthetic maximum (Pmax) compared to the brackish ecotype of F. vesiculosus and F. radicans whereas both the brackish species have similar Pmax. A reason for higher Pmax in the marine ecotype of F. vesiculosus compared to F. radicans is the greater relative amount of ribulose-1.5-bisphosphate carboxylase/oxygenase (Rubisco). The reason for higher Pmax in marine ecotype of F. vesiculosus compare to the brackish ecotype however is not due to the relative amount of Rubisco and further studies of the rate of CO2 fixation by Rubisco is recommended. Treatments of the brackish ecotype of F. vesiculosus in higher salinity than the Bothnian Sea natural water indicate that the most favourable salinity for high Pmax is 10 psu, followed by 20 psu. One part of the explanation to a high Pmax in 10 psu is a greater relative amount of PsaA protein in algae treated in 10 psu. The reason for greater amount of PsaA might be that the algae need to produce more ATP, and are able to have a higher flow of cyclic electron transport around PSI to serve a higher rate of CO2 fixation by Rubisco. However, studies of the rate of CO2 fixation by Rubisco in algae treated in similar salinities as in present study are recommended to confirm this theory.
Fucus vesiculosus L. (Blåstång) är en brunalg som i huvudsak växer i tidvattenzonen i marint vatten men arten klarar också att växa konstant under ytan i det bräckta Bottenhavet. Norska havet och den del av Bottenhavet, där algerna är insamlade i denna studie, har salthalterna 34-35 psu (praktisk salthaltsenhet) respektive 4-5 psu. F. radicans L. Bergström et L. Kautsky (Smaltång) är en nyligen upptäckt art (2005) som har utvecklats i Bottenhavet. F. radicans och Bottenhavets ekotyp av F. vesiculosus växer sida vid sida och har tidigare ansetts vara samma art. Sett till hela Östersjön, så ändras ytans salthalt från 25 till 1-2 psu mellan Östersjöns gräns mot Kattegatt och norra Bottenviken. Den låga salthalten i Östersjön beror på det höga flödet av sötvatten från älvarna och på ett litet inflödet av saltvatten i inloppet vid Kattegatt. Salthaltsgradienten är korrelerad med antalet arter som minskar med minskad salthalt. Östersjön är ett artfattigt hav och de arter som finns är till stor del en blandning av söt- och saltvattenarter. Det finns bara ett fåtal arter som är helt anpassade till bräckt vatten och F. radicans är en av dem. Exempel på miljöskillnader för F. vesiculosus i Norska havet och i Bottenhavet är salthalten, tidvattnet, ljuset och temperaturen. Tidvattnet i Norska havet gör att algerna växlar mellan att vara i vattnet och på land, vilket utsätter algerna för stora ljusskillnader, snabba och stora temperaturväxlingar samt även torka. De alger som växer i Bottenhavet har däremot en jämnare och lägre temperatur, istäcke på vintern och mindre tillgång på ljus eftersom de alltid lever under vattenytan. Skillnaderna i miljön mellan växtplatserna leder till skillnader i fysiologiska anpassningar. Anledningen till att F. vesiculosus och F. radicans valdes som studieobjekt i denna avhandling är att de är viktiga nyckelarter i Bottenhavet. F. vesiculosus och F. radicans är de enda större bältesbildande alger som finns i det artfattiga ekosystemet och de används därför flitigt som mat, gömställe, parningsplats och barnkammare för t.ex. fisk. Att de är nyckelarter gör det angeläget att försöka förstå hur algerna är anpassade och hur de reagerar på miljöförändringar för att få veta hur de kan skyddas och bevaras. F. radicans inkluderades även för att se hur en naturlig art i Bottenhavet är anpassad i jämförelse med den invandrade F. vesiculosus. Marin F. vesiculosus inkluderades för att vara en artreferens från artens naturliga växtplats. Studien visar att det finns fler vattenlösliga organiska substanser (finns vissa organiska substanser som har en proteinskyddande funktion) i den marina ekotypen av of F. vesiculosus än i Bottenhavets ekotyp. Anledningen till detta föreslås vara en anpassning till att växa i tidvattenzonen. Vid lågvatten utsätts F. vesiculosus från Norska havet för starkt ljus, uttorkning, och snabba temperatur- växlingar vilket gör att den kan behöva dessa organiska substanser som skydd mot fria syreradikaler som bildas under lågvattenexponeringarna. F. vesiculosus från Bottenhavet har troligen mist förmågan att syntetisera dessa substanser på grund av anpassning till att hela tiden växa under ytan. Mängden mannitol (socker) är högre i den marina ekotypen av of F. vesiculosus än i Bottenhavets ekotyp. Detta föreslås bero på högre fotosyntetiskt maximum i F. vesiculosus från Norska havet jämfört med ekotypen från Bottenhavet. Skillnaden i fotssyntetiskt maximum är bland annat kopplat till ljus- och salthaltskillnaden på algernas växtplatser. Denna teori styrks av att både fotosyntesen och halten av mannitol ökar i Bottenhavets ekotyp när den behandlas i högre salthalt. Studien visar även att båda ekotyperna av F. vesiculosus samt F. radicans har ett ojämnt förhållande mellan fotosystem II och I (PSII och PSI) med en dominans av PSI. Denna slutsats är baserad på fluorescens emissions mätningar vid 77 K (-196 °C) och mätning av den relativa mängden D1 protein (motsvarar PSII) och PsaA protein (motsvarar PSI). F. vesiculosus från Bottenhavet visar ett emission spektrum som pekar mot en jämnare fördelning av PSII och PSI jämfört med den marina ekotypen och F. radicans. Detta stämmer dock inte med förhållandet mellan D1/PsaA som indikerar att alla tre har mer PSI än PSII. Förklaringen till avvikelsen mellan metoderna antas vara att F. vesiculosus från Bottenhavet har större ljus-infångande antennpigment än marin F. vesiculosus och F. radicans. De tydliga skillnaderna i 77 K fluorescens emission spektra mellan Bottenhavets F. vesiculosus och F. radicans visar att denna metod kan användas som säker artidentifiering. Den marina ekotypen av F. vesiculosus har högre fotosyntetiskt maximum än de båda arterna från Bottenhavet. Mätningar av den relativa mängden av enzymet Rubisco, viktigt för upptaget av koldioxid hos växter och alger, visar att mängden enzym är en sannolik förklaring till skillnaden i fotosyntetiskt maximum mellan den marina ekotypen av F. vesiculosus och F. radicans och detta är troligen en normal artskillnad. Mängden Rubisco kan dock inte förklara skillnaden i fotosyntetiskt maximum mellan de båda ekotyperna av F. vesiculosus. För att undersöka vad skillnaden mellan dessa två beror på så föreslås istället mätningar av Rubisco’s koldioxidfixeringshastighet. Det är en ökning av fotosyntetiskt maximum i Bottenhavets ekotyp av F. vesiculosus när den behandlas i högre salthalt (10, 20 och 35 psu) och det högsta fotosyntetiska maximumet uppmättes i alger som behandlats i 10 psu. Denna ökning beror inte på ökning i den relativa mängden av Rubisco. Ökningen i fotosyntesen speglas dock av en ökning av den relativa mängden PsaA. Detta antas bero på att det behövs mer energi i form av ATP och att en ökning av detta kan ske på grund av att mer PsaA kan driva den cykliska elektrontransporten i fotosyntesreaktionen. Ökat behov av ATP antas bero på en ökning av Rubisco aktiviteten men mätning av aktiviteten krävs för att bekräfta detta.
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CHEN, MING-CHU, und 陳明珠. „Expression of chloroplest PsaA-PsaB operon in rice plants“. Thesis, 1992. http://ndltd.ncl.edu.tw/handle/75747668627410956357.

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Wu, San-pin, und 吳上賓. „Studies on the promoter-specific binding protein of the chloroplast psaA-psaB-rps14 operon“. Thesis, 1996. http://ndltd.ncl.edu.tw/handle/06212535716452319995.

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Harrington, Dean J., J. S. Greated, N. Chanter und I. C. Sutcliffe. „Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus“. 2000. http://hdl.handle.net/10454/11589.

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Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively investigated. Here we demonstrate the presence of a homologue of the Streptococcus pneumoniae PsaA protein in both of these equine pathogens. Inhibition of signal peptide processing by the antibiotic globomycin confirmed the lipoprotein nature of the mature proteins, and surface exposure was confirmed by their release from intact cells by mild trypsinolysis.
Project grant 056042 from The Wellcome Trust.
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Sommer, Frederik [Verfasser]. „Reverse genetics of PsaA and PsaB to dissect their function in binding and electron transfer from plastocyanin or cytochrome c6 to the core of photosystem 1 / von Frederik Sommer“. 2003. http://d-nb.info/970666071/34.

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Bücher zum Thema "Psača"

1

Pajor, Ferdinand. Eretria, Nea Psara: To chroniko mias politeias. Athēna: Ekdotikos Oikos Melissa, 2010.

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Pajor, Ferdinand. Eretria - Nea Psara: Eine klassizistische Stadtanlage über der antiken Polis. [Lausanne]: Ecole suisse d'archéologie en Grèce, 2006.

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Ikawati. Pengaruh hasil pelayanan PSAA terhadap kualitas sumber daya manusianya. Yogyakarta: Badan Kesejahteraan Sosial Nasional, Deputi Bidang Pendidikan, Pelatihan, Penelitian, dan Pengembangan Kesejahteraan Sosial, Balai Besar Penelitian dan Pengembangan Pelayanan Kesejahteraan Sosial, 2000.

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Papadopoulos, G. A. Lesvos-Chios-Psara: Hoi seismoi kai ta tsounami apo tēn archaiotēta mechri sēmera. Athēna: Ekdoseis Oselotos, 2015.

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Hartini, Ch. Penelitian tentang perbedaan dorongan untuk hidup mandiri antara anak asuh pria di PSAA Al Ikhlas, Ponorogo, Jatim dan anak asuh wanita di PSAA Yatim Putri Aisyiah, Yogyakarta. Yogyakarta: Badan Kesejahteraan Sosial Nasional, Balai Besar Penelitian dan Pengembangan Pelayanan Kesejahteraan Sosial, 2001.

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Kuntari, Sri. Penelitian ujicoba pemantapan model pengembangan PSAA sebagai piranti pembangunan Sumber Daya Manusia (SDM). Jakarta: Departemen Sosial RI, Badan Penelitian dan Pengembangan Kesejahteraan Sosial, Balai Besar Penelitian dan Pengembangan Pelayanan Kesejahteraan Sosial, 2000.

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Koumarianou, Maria K. Psara: Ta siōpēla monopatia tēs historias mia archeiakē kai ethnographikē meletē gia tē metavivasē periousias kai tēn koinōnikē diastrōmatōsē. Athēna: Hērodotos, 2017.

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Grivas, K. I. Hēmerologion tou polemou tou 1912. Athēna: A. Grivas, 1998.

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Xeroutsikou, Lousi. chios, inousses, psara. Toubi's, 1997.

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Michael Toubis Pub. S.A. Chisos Oinousses - Psara: The Fragrant Island. Greece, 1993.

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Buchteile zum Thema "Psača"

1

Xiao-Song, Gong, Wu Nai-Hu, Yan Jing-Zhi und Yen Lung-Fei. „Cloning and Nucleotide Sequence of Chloroplast psaA Gene from Sorghum“. In Biotechnology in Agriculture, 181–84. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1779-1_26.

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Luthra, Rajiv, Audrius Jasaitis, Fabrice Rappaport und Kevin Redding. „Directionality in Photosystem I: A Preliminary Study of the PsaA-A684D Mutant“. In Photosynthesis. Energy from the Sun, 167–71. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6709-9_38.

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„nɨv psaa kmae“. In Colloquial Cambodian, 76–89. Routledge, 2015. http://dx.doi.org/10.4324/9780203120651-9.

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„THE DESTRUCTION OF PSARA“. In Poems for the Millennium, Volume Three, 358–75. University of California Press, 2019. http://dx.doi.org/10.1525/9780520942202-043.

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„Appendix A PSAA National Officers“. In The Polish Singers Alliance of America 1888-1998, 187–93. Boydell and Brewer, 2005. http://dx.doi.org/10.1515/9781580466356-015.

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„Appendix M PSAA Districts and Choirs—1999“. In The Polish Singers Alliance of America 1888-1998, 283–86. Boydell and Brewer, 2005. http://dx.doi.org/10.1515/9781580466356-027.

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Lee, John W. I. „Excavating Eretria“. In The First Black Archaeologist, 171–202. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780197578995.003.0008.

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This chapter focuses on John Wesley Gilbert’s archaeological excavation and survey work at the ancient Greek site of Eretria, on the island of Euboea north of Athens. The chapter begins by explaining the history of Eretria from ancient to modern times and describing conditions in the modern village of Nea Psara (built atop the ancient ruins) when Gilbert arrived there in February 1891. From there, the chapter discusses Gilbert’s participation in the American School of Classical Studies at Athens’s excavations of the ancient cemeteries east of Eretria, especially on a grave that Charles Waldstein would erroneously identify as “the tomb of Aristotle.” The chapter then investigates the archaeological and topographical survey of ancient Eretria’s fortifications that Gilbert and his classmate John Pickard conducted, using their original survey map, essays they wrote from the site, and several preserved photographs. The chapter concludes by examining how the “tomb of Aristotle” fiasco overshadowed the valuable contributions of Gilbert and Pickard’s survey and discusses how African American participation in Greek archaeology might have developed differently had Gilbert excavated with the American School at Corinth in 1895 or afterward, rather than excavating at Eretria in 1891.
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Konferenzberichte zum Thema "Psača"

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Hao, Benjian, Jianfeng Zhu, Zan Li, Song Xiao und Lang Tong. „Passive Radar Source Localization Based on PSAAA Using Single Small Size Aircraft“. In 2015 IEEE Globecom Workshops (GC Wkshps). IEEE, 2015. http://dx.doi.org/10.1109/glocomw.2015.7413956.

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Silva, Izabella, Ana Ano Bom, Ana Argondizzo, Ariane Larentis, Marco Medeiros und José Silva Junior. „Structural characterization of pneumococcal surface antigen A (PsaA) of Streptococcus pneumoniae“. In I Seminário Anual Científico e Tecnológico em Imunobiológicos. Instituto de Tecnologia em Imunobiológicos, 2013. http://dx.doi.org/10.35259/isi.sact.2013_26662.

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Corrêa, Izabella, Ana Ano Bom, Ana Argondizzo, Ariane Larentis, Marco Medeiros, und José Silva Junior. „Effect of zinc on the structural stability of pneumococcal surface Antigen A (PsaA)“. In II Seminário Anual Científico e Tecnológico em Imunobiológicos. Instituto de Tecnologia em Imunobiológicos, 2014. http://dx.doi.org/10.35259/isi.sact.2014_28648.

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Wan, Pengwu, Zan Li, Benjian Hao, Boyang Liu und Jianfeng Zhu. „A new method of the virtual TDOA estimation for the passive radar source localization based on PSAAA“. In 2016 8th International Conference on Wireless Communications & Signal Processing (WCSP). IEEE, 2016. http://dx.doi.org/10.1109/wcsp.2016.7752601.

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Brownell, Ethan, Jonathan Cagan und Kenneth Kotovsky. „Does Design Proficiency Matter in Engineering Design Teams? A Computational Model and Experiments“. In ASME 2022 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/detc2022-89318.

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Abstract A cognitively inspired, agent-based model of engineering design proficiency is introduced in this work. Proficiency is modeled using move selection heuristics and problem space search strategies, both of which were extracted from a prior human subjects study. Agent behavior in the Proficient Simulated Annealing Design Agents (PSADA) Model is validated against human designer behavior and performance. A multi-agent model of design teams is then produced with Monte Carlo simulation methods and it confirmed the previous finding that the most proficient member of a configuration design team has the largest impact (positive or negative) on team performance. Further experiments are conducted with different team characteristics. It is found that the effect of individual team member proficiency is reduced in larger teams, but the highest proficiency team member likely remains the most influential. Nominal teams, where team members do not interact and where the best design is taken as the team output, were found to outperform interacting teams. This was due to high proficiency agents making poor decisions during interactions by switching away from their designs to the designs of their lower proficiency teammates. Conclusions about the role that individual team member proficiency plays in engineering design teams is discussed.
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Yongsa, Manivanh, Nguyễn Thị Thu Ngà, Sỹ Danh Thường, Nguyễn Hữu Quân und Chu Hoàng Mậu. „ĐẶC ĐIỂM TRÌNH TỰ VÙNG GENE psaA-ycf3 VÀ trnL-trnF TỪ CÂY CẨM CÙ LỘC (Hoya lockii V.T. Pham & Aver.)“. In HỘI NGHỊ KHOA HỌC QUỐC GIA LẦN THỨ 6 THÀNH PHỐ HUẾ. Nhà xuất bản Khoa học tự nhiên và Công nghệ, 2024. http://dx.doi.org/10.15625/vap.2024.0027.

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