Zeitschriftenartikel zum Thema „Project Jonah“

Abstract This article offers an introduction to the Textual History of the Ethiopic Old Testament (THEOT) project. This includes a description of the background to THEOT and its primary purpose of mapping the history of the transmission of the Ethiopic Old Testament. The bulk of the article summarizes the project’s preliminary findings, generally, and, in particular, about Ethiopic Psalms, Song of Songs, Deuteronomy, Ruth, Amos, Obadiah, Jonah, and Haggai. Some attention is also given to evidences of contact with the Hebrew text tradition, although the Ethiopic is clearly a daughter version of the LXX.

The following article attempts to answer the question if it is possible to find criteria enabling to solve the ethical-political dilemmas such as the one of Rospudy Valley on the grounds of Jonas ethical theory, the answer to this question is reconsidered in the context of Jonas philosophical project which is the establishment of ethics for life in the ontology of organic being. On the grounds of metaphysics, Jonas justifies the constitutive link between consciousness with being and the absolute good in affirmation of the importance of existence over non-existence. Jonas shows both the continuity and special discontinuity of the human being within the domain of the livings However, he is not able to support his argument that the human being is the primary object of responsibility being ahead of other forms of organic life. Jonas ethical theory ought to include the specification of moral principles that will be useful for clarifying the matters that must be preserved and defended.

Across various projects in the 1960s and ’70s, Joan Jonas created forms of self-portraiture enmeshed within environments. Engaging a range of media including mirrors, water, and video, Jonas repeatedly emphasized her body’s interrelation with surrounding natural and media ecologies. The resultant ecological portraits offer a model of being that encourages audiences to acknowledge their own embodiment in encounters with nature, whether experienced directly or through mediation. This article excavates this intermedia practice and explores the forms of ecocritical thought her performances and records might produce. Working in an era of expanding media experiments across performance, sculpture, and video, Jonas’s multimedia projects collaborate with the surrounding environment to explore the emergent openness of art in the 1970s. This article takes Jonas’s Disturbances (1974) as its starting point, arguing that Jonas featured the reflective and refractive properties of water to meditate upon the ecological resonances of the myth of Narcissus, the distorting optics of video, and the mediation of nature broadly. Similarly, in recent projection-based projects, Jonas has continued her exploration of the body’s relationship to both nature and media by incorporating her body into projected nature videos. In keeping with her stated unwillingness to “penetrate space,” ecological portraits across Jonas’s career reveal her multidirectional entanglements with spaces near and far, from waves in a pool to global oceanic crises.

Analysis, based on publications and scientific research of Lithuanian and foreign authors, presents the realia of health status and physical activity of young people. Scientific evidence has become compelling that sedentary lifestyle carries a risk for the development of coronary artery diseases, obesity, hypertension and other chronic diseases of adulthood. This article introduces the basic health–promoting activities and the Project “February – the month of Fitness“ implemented in Vilnius Jonas Basanavičius gymnasium. It is being organised for five years and involves all members of school society, guests and members of various educational institutions and non-governmental organizations. Guest from „ECO point“ and Vilnius University Faculty of Medicine took part in seminars and events organised during the projects. Those, who wanted to avoid heart and coronary artery diseases, were introduced to a booklet „The code of healthy European“. Consequently, in order to reinforce physical education also one of the key subjects at school is constantly looking for various ways to meet the student`s innate need to move, experience the joy of movement and to provide more opportunities through sports events and other projects. Indeed, it is aimed to involve the entire school community in this activity. Interest in physical activity is developed through socialisation and communication. Key words: health, physical activity, healthy lifestyle, project, socialisation.

The anomaly of Jonah's attitude in rejecting God's call (Jonah 1) and his anger at Nineveh's conversion caused various opinions on the genre of his book. This encourages the need to produce new findings to narrow the view of experts by placing the book of Jonah as satire literature. The purpose of this research is to describe the satire elements contained in the prologue and epilogue of the book of Jonah. The method used in this research is a narrative approach using a modified method that departs from the four narrative elements namely the narrator, character (characterization), point of view, and storyline then combined with some elements of general interpretation in it. through the narrative analysis method, the researcher sees the text as a "mirror" that projects a certain picture, namely the world of narratives that provides benefits to explore the forms and elements of the prologue and epilogical satire texts of the book of Jonah. The results showed that Irony underlies all elements of satire spread in articles 1 and 4. Researchers classify the elements of irony as personification, repetition, hyperbole, sarcasm, paronomasia, and parody. These characteristics indicate Jonah 1 and 4 are narratives containing satire. The implication of the teaching of the church by referring to the didactic values in the satire of the story of Satire Jonah can be used as a reference for learning the truth of God's Word. Abstrak Anomali sikap Yunus dalam menolak panggilan Tuhan (Yunus 1) dan kemarahannya pada pertobatan Niniwe menimbulkan beragam pendapat pada genre kitabnya. Hal ini mendorong adanya kebutuhan untuk menghasilkan temuan baru guna mempersempit pandangan para pakar dengan menempatkan kitab Yunus sebagai sastra satire. Tujuan dilakukan penelitian ini adalah untuk mendeskripsikan unsur satire yang terdapat dalam prolog dan epilog kitab Yunus. Metode yang digunakan dalam penelitian ini adalah pendekatan naratif menggunakan modifikasi metode yang berangkat dari empat unsur narasi yaitu narator, karakter (penokohan), sudut pandang, dan alur cerita lalu dikombinasikan dengan beberapa elemen penafsiran umum di dalamnya. melalui metode analisis naratif peneliti melihat teks sebagai sebuah “cermin” yang memproyeksikan gambaran tertentu, yaitu dunia narasi yang memberikan manfaat untuk mengeksplorasi bentuk dan unsur satire teks prolog dan epilog dari kitab Yunus. Hasil penelitian menunjukkan bahwa Ironi mendasari semua unsur satire yang tersebar di pasal 1 dan 4. Peneliti mengelompokkan unsur ironi adalah personifikasi, repetisi, hiperbola, sarkasme, paronomosia dan parodi. Karakteristik ini mengindikasikan Yunus 1 dan 4 adalah narasi yang mengandung satire. Implikasinya terhadap pengajaran gereja dengan merujuk pada nilai-nilai didaktis dalam satire kisah Satire Yunus dapat dijadikan rujukan untuk mempelajari kebenaran Firman Tuhan.

Bioethical challenges associated with the development of human e mbryo genome editing technologies are being investigated. The role of bioethics as a fo­rum for discussing the interdisciplinary anthropological and ethical problems generated by the progress of biomedical technologies is noted. The basis of con­tradictions and discussions around the acceptability of the technologies under consideration is the value ambivalence associated with the difference between the artificial and the natural. Almost any innovation in the field of biology and medicine, and here genome editing technologies are no exception, since its in­ception has been at the epicenter of a sharp ideological confrontation between supporters of the progressive technological transformation of the world and their opponents from the camp of environmentally concerned people of bio-conserva­tive values. Progressive ideas are refined through ideas the life instrumenta­lization. Bio-conservative ideas are substantiated by the principle of natality H. Arendt, which is used by J. Habermas in criticizing neo-eugenic projects and supported by G. Jonas in the concept of ecological imperative. The problem of the moral status of embryos, the specific advantages and disadvantages of con­servative and liberal positions are analyzed, and a retroactive model of the moral status of embryos is proposed, which represents a specific social construction. The project of normative monitoring of the consequences of using human em­bryo genome editing technologies Sh. Yasanoff is discussed. Its connection with the ideas of ethics of responsibility of H. Jonas is established.

O artigo pretende analisar as imbricações entre artes visuais e linguagem cinematográfica no pensamento acerca de uma estética videográfica. Toma-se como objeto analítico o projeto “365 Day Project”, de Jonas Mekas. Partindo da afirmação do autor Philippe Dubois de que os conceitos da linguagem cinematográfica não são suficientes para problematizar as práticas videográficas, a pesquisa utiliza conceitos comuns à teoria da imagem e à filosofia da arte, especificamente os conceitos de “altermodernismo”, desenvolvido por Nicolas Bourriaud e de “gesto”, desenvolvido por Giorgio Agamben, para discutir o modo como a relação entre as obras videográficas e os dispositivos audiovisuais se torna produtora de subjetividades em um campo híbrido à linguagem do cinema e das artes visuais.

O artigo pretende analisar as imbricações entre artes visuais e linguagem cinematográfica no pensamento acerca de uma estética videográfica. Toma-se como objeto analítico o projeto "365 Day Project", de Jonas Mekas. Partindo da afirmação do autor Philippe Dubois de que os conceitos da linguagem cinematográfica não são suficientes para problematizar as práticas videográficas, a pesquisa utiliza conceitos comuns à teoria da imagem e à filosofia da arte, especificamente os conceitos de "altermodernismo", desenvolvido por Nicolas Bourriaud e de “gesto”, desenvolvido por Giorgio Agamben, para discutir o modo como a relação entre as obras videográficas e os dispositivos audiovisuais se torna produtora de subjetividades em um campo híbrido à linguagem do cinema e das artes visuais.

Dialogical Self Theory has contributed to the endeavors to map and grid self-identity work in transition from military to civilian life throughout an empirical and longitudinal research project which focuses on existential dimensions. This article is based on a case study from this project and centers upon Sergeant Jonas, who, upon his return from deployment in Afghanistan, struggled with his transition as a new existential position was vocalized throughout the following annual interviews. This voice narrated feelings of meaninglessness, emptiness, and of having been deceived. In turn, this existential voice required an answer to a question which apparently had no answer. The meaning-making eventually evolved into an acceptance which enabled Jonas to proceed with his life. Dialogical processes between positions are important in order to go on with life amid existential concerns in the aftermath of military service since dialogicality of the self opens up a complex of dynamics of meaning-making processes, negotiations, and transformations. Based on the findings, it is suggested that the Personal Position Repertoire could potentially be strengthened by the addition of an internal existential position to its standard repertoire, at least when working with military personnel and/or veterans.

While serving as International Expert at the Research Institute of Anthropology and Ethnology, Jishou University in Xiangxi Autonomous Prefecture of Hunan Province, China, on United Nations Educational, Scientific and Cultural Organization-Local and Indigenous Knowledge Systems (UNESCO-LINKS) Natural Science Sector, United Nations Permanent Forum on Indigenous Issues (UNPFII), United Nations Department of Economic and Social Affairs (UNDESA) projects with the Kam people of China and ministries responsible for ethnic development, I asked my ethnic minority graduate students and colleagues of China this question, “How did the Cultural Revolution affect your culture?”, and they thoughtfully shared their perspectives and experiences.

This article claims that prominent literary works published and discussed in Denmark in the 2010s strive to avert irony, seeking a solid basis. Examples include Karl Ove Knausgård’s project of documentation; Asta Olivia Nordenhof’s straight, clear-sighted addressal; Jonas Eika’s search for a neutral voice inspired by Simone Weil; and the decade’s agitated debates about Yahya Hassan and Christina Hagen.

Abstract Background: Galectins are sugar binding proteins that play a role in adhesion, apoptosis, immune regulation, and many other cellular processes. There are three different classes of galectins, and they are all found intracellularly and secreted in serum. Galectins have an established relationship with breast cancer, and galectin-3 has been repeatedly associated with cancer cell survival and tumor progression. Most research regarding breast cancer and galectins has used immunohistochemistry (IHC) as a method for identifying galectin expression in breast cancer tissue samples. However, little research has identified a relationship between serum galectin concentrations and breast cancer subtypes. Breast cancer is characterized both by histological and molecular subtype, and this identification often directs treatment decisions. The current method for identifying breast cancer subtypes is through invasive biopsy and the subsequent use of IHC. This project characterized serum galectin concentrations in breast cancer patients to determine if they changed based on different histological and molecular subtypes, cancer stage, and other patient characteristics. Our goal was to evaluate a potential noninvasive means of breast cancer subtype identification and to identify potential therapeutic targets. Methods: One-hundred breast cancer patient serum samples were studied using Enzyme-linked Immunosorbent Assays (ELISAs) to determine concentrations of galectins -1, -3, -7, and -9. Results were compared using many patient characteristics, including breast cancer subtype, stage, and patient history (smoking status and treatment). Statistical Analysis was performed using ANOVA, Student’s t-test, and the Wilcoxon Method. Results: The concentrations of galectins -1, -3, and -9 in breast cancer patients were all significantly higher than those of healthy controls (Table 1), which is consistent with previous studies. The concentration of galectin-3 was significantly higher in invasive lobular carcinoma samples (N, 6; mean, 13.04 ng/mL) compared to invasive ductal carcinoma samples (N, 80; mean, 9.93 ng/mL; p-value, 0.0428). Galectin-3 concentrations were significantly lower in samples from breast cancer patients who received chemotherapy (N, 9; mean, 9.22 ng/mL) versus those who did not (N, 7; mean, 14.60 ng/mL; p-value, 0.0228). Concentrations of galectin-1 were found to increase by stage (p-value, 0.0031), with significant differences between samples from patients with stage I breast cancer (N, 45; mean, 19.02 ng/mL) and both stage II (N, 40; mean, 24.15 ng/mL; p-value, 0.0127) and stage III (N, 12; mean, 28.37 ng/mL; p-value, 0.0026) disease. Conclusions: Our findings suggest a potential use for serum galectin-3 concentrations as a non-invasive means for breast cancer histological subtype differentiation and more refined diagnosis. In addition, our results suggest a possible use of galectin-1 concentrations for more accurate cancer staging. Further research could explore the relationship of serum galectin concentrations and other breast cancer subtypes. Future studies could also analyze how galectin concentrations change with patient treatment status and determine the potential of galectins as specific targets for breast cancer treatment. Table 1: Galectin Concentrations in Breast Cancer vs Healthy Controls Citation Format: Jonah Shealy, Alex Kesic, Avery Funkhouser, Julie Martin, W. Larry Gluck, w. Jeffery Edenfield, Anna Blenda. Analysis of Serum Galectin Profiles by Breast Cancer Subtypes and Patient Characteristics [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-23-18.

Jonas Ross Kjærgård. Adjunkt i Litteraturhistorie, Aarhus Universitet. Han har skrevet en litteraturhistorisk ph.d.-afhandling om sammenhængen mellem lykke og menneskerettigheder i årene op til og under Den Franske Revolution og arbejder pt. på et projekt om den haitianske revolutions litteraturhistorie i Frankrig, Tyskland, USA og Haiti i årene 1791-1859.

How did the Lithuanian patriarch Jonas Basanavičius inspire the nation with his scientific research? The idea as a movement and development of science fits into the problem of nationalism in the history of the Russian Empire and European science. My aim is to analyse Basanavičius’ studies, ideas and research into the Lithuanian nation in the fields of anthropology, ethnology and ethnography from 1879 to 1927. I argue that German ethnology may have influenced Basanavičius’ theoretical concept of nation studies. In my analysis, I focus on the following issues: (1) the projects of the Science Society in Lietuviška Ceitunga, Aušra, Varpas and other publications; (2) research in biological anthropology; (3) studies of ethnology and ethnography; (4) collecting antiques; (5) ‘ethnographic’ fellowship; (6) the national research programme; and (7) studies of the Lithuanian nation. Key words: cultural nationalism, Europe, Jonas Basanavičius, Lithuanian Science Society, Russian Empire, Völkerkunde.

Abstract The aim of the article is to support critical consideration about what quality is and might be in ECEC. It argues that two different quality cultures – understandings of what quality is, how it may be understood and supported – intersect and create tensions in relation to the ECEC area in Denmark. One is analyzed as influenced by a transnational quality discourse, a specific regime of truth regarding quality as a phenomenon “out there” that must be defined and assessed to improve. This technical-instrumental quality culture needs to be balanced by a quality culture founded in pedagogy as a distinct perspective foundational for ECEC. Drawing on a continental tradition of pedagogy as a human science discipline the article offers a language and understanding of pedagogical qualities. Such qualities refer to the attributes of pedagogy and go beyond what is easily disregarded as subjective in the prevailing quality culture. To identify such pedagogic qualities the article revisits empirical data from a narrative research project that explored pedagogic knowledge at play in ECEC professionals’ practice. The article argues that a critical quality culture founded in thoughtful consideration and ethical balancing of pedagogical qualities is crucial for the sake of the children and our democratic society.

The importance of polylingual education has grown significantly in recent decades. Recognizing the importance of multilingual education, the language policy of the European Union provides for the preservation and development of the native language of the EU, as well as a perfect knowladge of at least two foreign languages. The introduction of polylingual education has already reached the scale of public policy in many EU countries, including Greece, Denmark, Estonia, Iceland, Italy, Cyprus, the Netherlands, Portugal, Romania, Finland, Sweden and Switzerland. Multilingualism should be considered not only as a communicative compulsion, but as a necessity for the sustainable development of society in any country of the world and an important factor in life in the period of global development. Analysis of publications shows that multilingualism is a feature of the modern country, demonstrates the successful coexistence of multilingual societies. These facts reveal the importance of the transformation of school education. Particular importance is attached to the problem of mastering foreign languages. The European Center for Modern Languages provides examples of successful introduction and functioning of polylingual education in educational institutions of different countries. All these projects are included in the general project of the European Center for Modern Languages of the Council of Europe "PlurCur". The language concept of Ukrainian education needs changes and improvements, reorientation to polylingual education. The experience of the PlurCur project in a common educational context in all languages studied is especially useful for Ukraine. We make assumptions about the possibility of introducing a model, programs and other components of this project in the education system of Ukraine. The idea of polylingual education is considered in the article and the schemes of the polylingual program in the form of the diagrams by Britta Hufeisen and Jonas Erin are offered. Taking into account the proposed models of multilingual education programs, as well as taking into account the national language and educational context of Ukraine, we propose a general model of multilingual education, which can be considered as one of the possible options for multilingual education in Ukraine, for the development of polylingual competence of students.

Today, the Limburg landscape shows little evidence of its mining past. Existing artwork, on the other hand, regularly references the mining industry. Among the different types of artwork, stained-glass windows are perhaps an unexpected artistic witness of the mining industry and as such constitute a largely overlooked part of mining heritage. This article focuses on these mining windows, which depict the mining industry in various ways. Mining windows have not been the subject of many studies, nor does an overarching catalogue exist. This incited the authors and the Centre for the Social History of Limburg (SHCL) to create the GLiM-project (Stained-glass windows and Dutch mines). The project focuses on compiling an online database of mining windows, starting with those in Dutch Limburg. This article introduces the GLiM-database and zooms in on three case studies: ‘Heilige Barbara’ (1932/1937) by Henri Jonas in Bleijerheide, ‘Eigenschappen van steenkool’ (1938) by Joep Nicolas for DSM, and ‘Het gezonde leven in Limburg’ (1954) by Charles Eyck for the Sanatorium Hornerheide.

Starting from the example of the Amazon, in Brazil, we intend to analyse how technology (mainly in its biotechnological face) appears as a threat to biodiversity, insofar as it acts through a reduction and standardization: technology needs to reduce diversity to something knowable to be able to control and exploit, in view of human necessities. In this sense, according to Hans Jonas, it is necessary to ask about the horizon of the future giving preference to the negative prognosis (fear rather than hope) to avoid that the harmful consequences of nihilism (marked by the absence of criteria capable of guiding technological action) affect life decisively. In this case, the Enhancement project proposed by transhumanism appears as yet another chapter in the history of risks represented by modern technology.

The essay argues that a proper ethical foundation for the political processes underlying liberal democracy is unattainable in a globalized society made possible through networked computers – and the transformed relationship with temporality that is generated by them. The essay brings together the computer ethics of Norbert Wiener and the temporal ethics of Hans Jonas to show that both original visions for a better world are unrealizable in the unanticipated context of what is termed ‘network time’. The essay argues further that to develop an ethical basis for liberal democracy, digital logic and its effects must be contrasted with that which they ceaselessly colonize and marginalize today: an irreducibly analogue world, with analogue politics, analogue technologies and analogue humans who conceived and developed liberal democracy as a cornerstone of the project of Enlightenment. Through contrast and critique, the essay reveals the difficulty for any ethico-political project within the digital and argues that the present post-modern relationship with computing, in which ‘market forces’ determine technological forms and applications, is socially destructive and must be brought under a new aegis of democratic and common responsibility.

Abstract Redistribute Toxicity was a commissioned art piece created by visual artist Jonas Staal in close collaboration with environmental historian Jonas Stuck and curator and researcher Caroline Ektander, and later enriched by the knowledge and practices of seed librarian, artist, and activist Zayaan Khan for the exhibition The Long Term You Cannot Afford: On the Distribution of the Toxic at SAVVY Contemporary in Berlin in 2019. Informed by historical research on the trade of hazardous waste between the two Germanys during the Cold War—with a particular focus on the landfill Vorketzin, which served as West Berlin’s primary hazardous waste disposal site during the division—the art commission asked us to consider what an act of redistribution of a toxic past could look like. Similar to other waste practices premised on systems of externalization, the one that transpired between a divided Germany resulted in an asymmetrical impact on human, animal, and plant lives populating the former East—effects that are till this day hard to account for. The research process generated a series of designs that exposed the various practical and ethical issues entangled with acts of retribution and helped shape a project that became less concerned with correcting the past and more committed to reconfiguring toxic relations in the present. The final installation design propagated seeds from the wetland vegetation surrounding the landfill. This wild vegetation had not only become implicated in Germany’s toxic history as silent witnesses but had also helped remediate the soils over time.

Introduction: Adults living in bateyes (i.e., sugarcane plantation villages) in the Dominican Republic have minimal access to health care services. Hypertension (HTN) is a serious and often unrecognized health problem among batey residents. The Jonas Batey Hypertension Program was built on existing social networks to address the detection and treatment of HTN. Methods: An ongoing community-based participatory research endeavor involves a partnership among three organizations and collaboration with promotoras who engage their batey communities in a mobile HTN screening and treatment program. Adults are screened and, if indicated, are treated with antihypertensive medications. Data collection includes project documentation, participant observation, demographic data, blood pressure (BP) measurements, and pill counts. Results: To date, 243 adults have received HTN treatment in four batey communities. A within-group, as-treated, repeated-measures, pre-/postanalysis showed that among participants who had been receiving antihypertensive treatment for 12 months ( n = 70), there was a significant decrease in BP ( p < .005). Conclusion: Results of an interim data analysis indicate that the program model has been implemented successfully and is making a positive impact on BP control. Evaluation is ongoing with regard to the long-term HTN-related health outcomes of batey residents. Ensuring program sustainability is an important consideration for the future.

Aušrinė Barakauskienė1, Arvydas Laurinavičius1, Kęstutis Strupas2, Arida Buivydienė2, Vitalijus Sokolovas2, Marius Paškonis2, Jonas Valantinas2, Jonas Jurgaitis21 Valstybinis patologijos centras, P. Baublio g. 5, LT-08406 Vilnius2 Vilniaus universiteto Santariškių klinikų Gastroenterologijos,urologijos ir abdominalinės chirurgijos klinika,Santariškių g. 2, LT-08661 VilniusEl paštas: ausrine.barakauskiene@vpc.lt; jonas.jurgaitis@santa.lt Įvadas / tikslas Atmetimo reakcijos morfologinių parametrų pokyčių tikslus vertinimas gali užtikrinti ligonio gyvenimo kokybę po kepenų transplantacijos. Straipsnio tikslas yra pateikti ūminio kepenų transplantato atmetimo diferencinės diagnostikos iš bioptato literatūros apžvalgą ir pasidalyti savo praktine patirtimi vertinant nulinę kepenų biopsiją bei ūminę (ląstelinę) atmetimo reakciją bioptate. Metodai Straipsnyje apibendrinamos teorinės žinios, įgytos Heidelbergo universiteto Patologijos institute, dalyvaujant Leonardo da Vinčio projekto mokymo programoje „Kepenų transplantacijos įgūdžių tobulinimas“ 2006 m. balandį – birželį. Šios žinios susijusios su kepenų biopsijos taikymo ortotopinėje kepenų transplantacijoje prognozine verte. Straipsnyje pateikiami morfologiniai vaistų sukelti pokyčiai ir apibendrinamas vaistų atsakas į gydymą. Rezultatai Remiantis asmenine patirtimi nurodoma nulinės biopsijos praktinė reikšmė, pateikiama ūminio (ląstelinio) atmetimo morfologinė diagnostika. Aprašomi ir šešiuose paveiksluose pavaizduojami šios reakcijos pagrindiniai komponentai, jų diferencinė diagnostika, nurodomi praktiški laipsniavimo sistemos principai. Išvados Atmetimo reakcija turi būti vertinama kompleksiškai – tai gastroenterologų, chirurgų, imunologų ir patologų komandos darbas. Gebėjimas kompleksiškai įvertinti ir interpretuoti tiek klinikinius, tiek morfologinius pokyčių parametrus gali užtikrinti ligonio gyvenimo kokybę po kepenų transplantacijos. Pagrindiniai žodžiai: ortotopinė kepenų transplantacija, ūminė (ląstelinė) atmetimo reakcija, Banff schema, nulinė biopsija, atmetimo aktyvumo indeksas The differential diagnosis of acute liver allograft rejection in the biopsy Aušrinė Barakauskienė1, Arvydas Laurinavičius1, Kęstutis Strupas2, Arida Buivydienė2, Vitalijus Sokolovas2, Marius Paškonis2, Jonas Valantinas2, Jonas Jurgaitis21 National Centre of Pathology, P. Baublio g. 5, LT-08406 Vilnius, Lithuania2 Kaunas University of Medicine,Insitute for Biomedical Research,Eivenių g. 4, LT-50009 Kaunas, LithuaniaE-mail: ausrine.barakauskiene@vpc.lt; jonas.jurgaitis@santa.lt Background / objective Histological assessment of liver biopsies provides important information for the management of patients undergoing liver transplantation and for the differential diagnosis of other diseases. The aim of the article is to summarize the theoretical knowledge obtained from the University of Heidelberg at the Institute of Pathology participating in the Leonardo da Vinci project “Competence improvement in liver transplantation” in April–Juny 2006, and our own experience to determine acute (cellular) rejection, “time-zero” biopsy. Results There are three main morphological criteria of the rejection activity index to be evaluated: portal tract inflammation, bile duct damage and venous endothelial inflammation. The main histological features of acute (cellular) rejection are described and assessed in six pictures, and a practical approach to the scoring system (Banff scheme) is presented. In addition, there are described morphological changes caused by drugs as a response to treatment. Conclusions The assessment of acute (cellular) rejection should be carried out together with clinicians, surgeons, immunologists and pathologists working in team. The capability to evaluate all the clinical and morphological data in complex ensures the quality of life of the patient after liver transplantation. Key words: liver allograft rejection, acute (cellular) rejection, Banff scheme, “time-zero” biopsy, rejection activity index

En Lc 11,29-32, la figure de la reine du Midi passe facilement inaperçue, prise entre la sagesse de Salomon, la conversion des Ninivites et « le signe de Jonas ». Pourtant dans le 3 e évangile qui ne contient pas de scène de Jugement dernier, la reine et les hommes de Ninive se voient attribuer par Jésus les rôles de témoins à charge et de juges de la génération du Christ.Cette étude se penche sur le déplacement intertextuel opéré entre la reine de Saba en 1 Rois 10 et 2 Chroniques 9 (et parallèles dans la Septante), et la reine du Midi en Lc 11,31, dans le sens d’une majoration du rôle de la reine.L’étude est prolongée par une hypothèse sur la portée symbolique de l’origine géographique du personnage et son inclusion dans un projet missionnaire universel.

This study aims to spotlight the postmodern tendency of metafiction in Ian Watson’s novel “Chekhov's Journey”. Metafiction is self-conscious in relation to language, literary form, and storytelling in fiction. This form of fiction accentuates its construct and reminds the readers to be aware of a fictional work. Ian Watson is a noteworthy science-fiction writer, and his famous novelsare ‘The Embedding’ (1973) and ‘The Jonah Kit’ (1975), which brought him prestigious awards, while in this study we will focus on his metafictional work ‘Chekhov’s Journey’. This novel exhibits the subject of postmodern metafiction. In this novel, a modern-day actor uses hypnosis to simulate Anton Chekhov's 1890 journey through Siberia. The method of study adopted the metafiction theories proposed by Patricia Waugh and Linda Hutcheon. It highlights Ian Watson’s texts that represent the elements of metafiction through the protagonists. Using various theories related to postmodern metafiction, the view of metafiction in the work is substantiated and explored. The postmodern perspective of metafiction is explored in Ian Watson’s text and analyzed with metafiction theories. The study results are compared and discussed with other studies and contemporary texts concerning metafiction. The findings show that metafiction is applicable in the given work of Ian Watson. He projects the aspects of metafiction in his work through his writing, especially narration, both fiction and reality.

The concept of global education is based on the recognition of the world as a network of interdependencies and on realizing the fact that the current direction of the development of civilization is leading to environmental and humanitarian disaster. On the other hand, there is a belief that there is still a chance to change this state of affairs by means of education. The purpose of education is recognized as not only a transfer of knowledge, but also as a transfer of morals that are able to generate a shift in attitudes. In order to strengthen the impact of the global education project, it is necessary to provide a coherent description and axiological analysis of the values behind it. In the paper, we argue that ethicists should work on building philosophical arguments for the development and implementation of global education programs. We argue further that such a philosophical framework should be based on the ideas of new humanism (proposed by Aurelio Peccei) and global responsibility (formulated by Hans Jonas).

Abstract Restrictions on the scope of government action by forcing authorities to act exclusively to the extent permitted by law are a guarantee against abuses of power when authorities’ decisions have environmental implications. Such control ensures that this becomes a reality because it provides a way by which to overcome administrative inefficiency and avoid departure from the essential aims of public institutions. Environmental commitment is necessary for denationalization of the state; it appears as a subsidiary to the initiative and participation of citizens, which, by shifting functions to the private sphere, is also linked to destatization strategies. In light of these assumptions, and the consideration that decisions should not be taken without the input of communities, this article advocates the inclusion of citizens’ voices in environmental policies and management. These issues are addressed from the perspective of Hans Jonas’ ethic of responsibility, with the aim to develop socially responsible and participatory projects.

Purpose – This investigation is guided by the following research questions: employing Hart and Milstein’s (2003) Sustainable Value Framework as analytic tool, what is the extent of the integration of sustainability focused strategies by Asian-based companies in their corporate social responsibility (CSR) initiatives? How can the ethics of responsibility of Hans Jonas help rethink the current understanding and doing of CSR in Asia towards achieving a truly responsible and sustainable corporate identity? Design/methodology/approach – This research uses Centering Resonance Analysis (CRA), which is a relatively sophisticated form of content analysis methodology suitable for studying formal written communication such as the published CSR reports. To accomplish the complex task of CRA, the Crawdad Text Analysis System 1.2 is used. The Crawdad Text Analysis Software is an analytical software package developed specifically to perform CRA. Findings – Using the Hart and Milstein Sustainable Value Framework as a diagnostic tool, the empirical findings reveal that Asian-based companies’ CSR projects exhibit a very low degree of integration of sustainability strategies. This paper proposes a theoretical process model that explains the planned development of CSR initiatives – through a CSR tract elucidated as corporate sustainability and responsibility – a holistic management approach aimed at providing impetus for companies in Asia to pursue the goal of becoming responsible and sustainable companies. It reconciles the concepts of CSR and corporate sustainability using Hans Jonas’ ethics of responsibility as the philosophical footing. Research limitations/implications – The primary objective of this study, therefore, is to examine how companies located in Asia embrace sustainability in their CSR engagement. It stems back to the fundamental question, “How do companies in Asia manage their CSR” – i.e. as a strategic response to changing circumstances and new corporate challenges? This question drives this study’s search for empirically based conclusions on current CSR program thrusts and the advancement of sustainability strategies of firms operating in Asia. Practical implications – Building upon the empirical results gained from the above objective is the equally important goal of the study to advance Hans Jonas’ ethics of responsibility as a basis for a blueprint to a revitalized view of CSR amongst Asian firms in their pursuit to become responsible and sustainable corporations. The integration of philosophical theory adds foundational depth to the study. Social implications – Building upon the empirical results gained from the above objective is the equally important goal of the study to advance Hans Jonas’ ethics of responsibility as a basis for a blueprint to a revitalized view of CSR among Asian firms in their pursuit to become responsible and sustainable corporations. The integration of philosophical theory adds foundational depth to the study. Originality/value – This multidisciplinary study seeks to contribute to CSR literature in two ways. First, it highlights the significance of the need for empirical descriptions of firm-level CSR structures and practices that may give a more thorough account of the overall quality of business involvement of Asian-based firms on sustainability issues. Second, this investigation underscores the need for conceptual robustness to guide CSR initiatives undertaken by firms within a sustainability paradigm. A grounded theoretical model is henceforth presented in this paper to enrich the discussion on the strategic management of ecological responsibility through a holistic approach to CSR.

This paper summarises the research material of the ongoing global grant project, “Modern Research of Geolinguistics in Lithuania: Optimisation of Network of Points and Interactive Spread of Dialectal Information.” The project aims to collect the most important sociolinguistic data of the entire Lithuanian language area, with the purpose of carrying out a primary analysis of the items found in order to make a record of the Lithuanian language situation at the beginning of the 21st century.In fact, the collecting of toponyms started earlier, especially after the foundation of the Group of Onomastics at the Lithuanian Academy of Sciences, at the Institute of the Lithuanian Language and Literature in 1958. In the period of 1976–1986, the Institute, in collaboration with the Society of Heritage Protection and Regional Studies, launched 11 major expeditions to several regions of Lithuania. Expeditions on onomastics and dialectology were also organised at the Vilnius University Kaunas Faculty of Humanities. In the period of 1979–1989, students of the Kaunas Faculty of Humanities, supervised by Albertas Ružė, collected the onyms in the Samogitian region (Telšiai, Mažeikiai, Akmenė and two-thirds of the Skuodas district). During the abovementioned period, two two-day long annual expeditions to the birthplaces of outstanding Lithuanian linguists (e.g., Juozas Balčikonis, Jonas Kazlauskas and others) were organised. In 1977–1988, the expedition members, under the direction of Alvydas Butkus, collected the onyms in such areas as Ukmergė, Molėtai, Utena, Kaunas, Pasvalys, Biržai, Jurbarkas, and Lazdijai.The paper overviews one aspect of the item questionnaire, i.e., the onomastics of part of the live language heritage: toponyms and nicknames. The research is based on the descriptive method and deals with the analysis of the toponyms and nicknames of the dialectal items of the Pasvalys, Kaunas and Marijampolė counties. Moreover, it gives an explanation of the folk etymology of the item names. The research involved 87 informants (of both genders) from different dialect areas and of different generations – the younger (under 30 years old), the middle (31–49 years old), and the elder (50 years old and over). Due to the rather fresh start of the project, the current paper presents only some initial insights, which will be revised upon the completion of the project.

In this paper I argue for recognizing the moral duty to participate in research. I base my argument on the need for biomedical research and the fact that at some point studies require human participants, what I call collaborative necessity. In presenting my position, I argue against the widely accepted views of Han Jonas and all of those who have accepted his declarations without challenge. I go on to show why it is both just and fair to invite and encourage people to participate in studies. It is just because research participation is the necessary means to achieve the broadly shared goals of preventing and curing disease and alleviating disease symptoms. Mutual love requires us to be willing to do for others what we would want them to do for us. It is fair because the approach treats similarly situated people in the same way. Research participation is morally required because failing to do one's part in the collaborative project of advancing biomedical science would be free-riding. People who exempt themselves from participation while eagerly accepting benefits from others doing their part are taking advantage of their compatriots and treating themselves as more deserving than others when they are not.

AbstractThis December Issue of Cardiology in the Young represents the tenth annual publication generated from the two meetings that compose “HeartWeek in Florida”. “HeartWeek in Florida”, the joint collaborative project sponsored by the Cardiac Center at the Children's Hospital of Philadelphia, together with All Children's Hospital of Saint Petersburg and Johns Hopkins Medicine, averages over 1000 attendees every year and is now recognized as one of the major planks of continuing medical and nursing education for those working in the fields of diagnosis and treatment of cardiac disease in the fetus, neonate, infant, child, and adult. “HeartWeek in Florida” combines the International Symposium on Congenital Heart Disease, organised by All Children's Hospital and Johns Hopkins Medicine and entering its 13th year, with the Annual Postgraduate Course in Pediatric Cardiovascular Disease, organised by The Children's Hospital of Philadelphia and entering its 17th year. The theme of this supplement generated from the 2012 HeartWeek in Florida is “A Lifelong Interdisciplinary Approach to Common Arterial Trunk, Transposition of the Great Arteries, and Other Evolving Challenges in Paediatric and Congenital Cardiac Disease”. We would like to acknowledge the tremendous contributions made to medicine by Richard Jonas; and therefore, we dedicate this HeartWeek 2012 Supplement to him.

Summary During rescue excavations carried out near the vicus at Kempraten (municipality of Rapperswil-Jona, St. Gallen, Switzerland) in advance of a private construction project, a Mithraeum measuring approximately 8 by 10 m was unexpectedly discovered in the summer of 2015 and subsequently excavated and investigated in detail. This paper presents the preliminary results of the excavation, which was completed less than a year ago, and pays particular attention to the interdisciplinary approach used in the excavation. These included intense sampling of the features for the purposes of micromorphology and archaeobiology. Three construction phases with intermittent conflagrations were identified. The question as to whether there was an ante-chamber remains unanswered. The external areas are also quite difficult to interpret, at least for the time being. The rich assemblage of finds, which included numerous coins, pottery, animal bones and a range of religious artefacts (e.g. altars and a half relief), will only be dealt with in a cursory manner here. According to the range of coins, the Mithraeum undoubtedly dated from the late 3rd to the late 4th or early 5th centuries. The site will be analysed by an interdisciplinary team and preliminary work is already underway.

Rakenteiden Mekaniikka -lehti juhli 50-vuotista taivaltaan viime elokuussa Vaasan yliopistossa järjestetyssä juhlaseminaarissa. Seminaarin esitelmien pohjalta kirjoitetuista lyhyistä artikkeleista koottiin lehteemme paksu erikoisnumero (Vol 50, Nro 3), jollaisia on itse asiassa vuosien varrella julkaistu lehdessämme lukuisia. Perinne jatkuu tänäkin vuonna: loppuvuodesta on tarkoitus koota erikoisnumerot sekä Teräsrakentamisen T&K-päivien (15.–16.8. Hämeenlinnassa) että Suomen mekaniikkapäivien (29.–31.8. Helsingissä) esitelmien pohjalta. Lehden uutena päätoimittajana pyrkimykseni on muiltakin osin jatkaa vuosien saatossa hyväksi havaittujen periaatteiden ja linjausten mukaista julkaisutoimintaa. Lehteä on luonnollisesti myös tarkoitus tarpeen mukaan uudistaa. Osa uudistuksista tulee todennäköisesti kytkeytymään lehtemme uuteen verkkojulkaisualustaan, jona on vuoden ajan toiminut Tieteellisten seurain valtuuskunnan ylläpitämä, tiedelehtien toimittamiseen ja julkaisemiseen tarkoitettu Journal.fi-palvelusivusto. Sivustolla on tällä hetkellä noin 60 suomalaista tieteellistä lehteä ja vuosikirjaa ja se käyttää voittoa tavoittelemattoman Public Knowledge Project -yhteenliittymän kehittämää Open Journal Systems -järjestelmää, joka perustuu avoimeen lähdekoodiin ja on tällä hetkellä maailman yleisimmin käytetty julkaisujärjestelmä tieteellisessä julkaisemisessa. Kunhan järjestelmän käyttöönoton alkukankeuksista selvitään, tämän digitaalisen palvelualustan on jatkossa tarkoitus helpottaa lehtemme kirjoittajien, arvioijien ja toimituskunnan työskentelyä, mahdollistaa artikkelien nopeampi julkaiseminen sekä lisätä lehdessä julkaistujen artikkelien näkyvyyttä ja uskottavuutta. Lopuksi haluan vielä lehden puolesta kiittää edeltäjääni, professori Reijo Kouhiaa, joka toimi lehden päätoimittajana viimeiset yksitoista vuotta – toimittaen lehden volyymit 40–50 käsittäen yhteensä 228 vertaisarvioitua artikkelia – ja jatkaa edelleen lehden toimituskunnan jäsenenä. Helsingissä, 1. elokuuta 2018 Jarkko NiiranenRakenteiden Mekaniikka -lehden päätoimittaja, akatemiatutkija, apulaisprofessori

Summary During rescue excavations between 2009 and 2013 carried out at the periphery of the vicus at Kempraten (municipality of Rapperswil-Jona, St. Gallen, Switzerland) a Gallo-Roman sanctuary, dating from the second quarter of the 2nd to the end of the 3rd century AD, was unearthed. The excavation included intense sampling for geoarchaeology and archaeobiology, which prompted the Archaeology Department of Canton St. Gall (KASG) to launch an interdisciplinary project. Four curse tablets attest to the cult of Magna Mater in the sanctuary at Kempraten. This paper presents the first results of the interdisciplinary study and compares them to the Magna Mater sanctuary at Mainz (Germany), focusing on 1. the layout of the sanctuary, 2. sacrificing, 3. feastings and 4. cursing. The comparison between both sites showed that there was no strict setting of rituals in the cult of Magna Mater, but the importance of cursing and of burnt sacrifices is characteristic for both sites. Summing up: The temple precinct at Kempraten had a specific setting, which showed on one hand local and regional influences, for instance in terms of the temple architecture and the choice of food offerings. On the other hand, distinct differences between the Kempraten sanctuary and local Gallo-Roman sanctuaries can be observed, for instance in relation to cursing, the composition and the importance of the burnt offerings.

The article discusses the challenges, benefits, and risks that, from a bioethical perspective, arise because of the the development of eHealth projects. The conceptual framework of the research is based on H. Jonas’ principles of the ethics of responsibility and B.G. Yudin’s anthropological ideas on human beings as agents who constantly change their own boundaries in the “zone of phase transitions.” The article focuses on the events taking place in the zone of phase transitions between humans and machines in eHealth. It is shown that for innovative practices related to digitalization and datafication in medicine, it is needed to rethink central bioethical concepts of personal autonomy and informed consent. In particular, the concept of broad or open informed consent is discussed, which allows the idea of moral responsibility in the field of biomedical technologies to be extended to events of uncertain future. The authors draw attention to the problems associated with the emergence of new autonomous subjects/agents (machines with artificial intelligence) in relationship between doctors and patients. The humanization of machines occurring in eHealth is accompanied by a counter trend – the formation of conceptions and practices of the quantified self. There emerges the practices of self-care and bio-power (M. Foucault) caused by the datafication and digitization of personality. The authors conclude that bioethics should proactively develop norms for the evolving interaction between doctor and patients.

The article discusses the challenges, benefits, and risks that, from a bioethical perspective, arise because of the the development of eHealth projects. The conceptual framework of the research is based on H. Jonas’ principles of the ethics of responsibility and B.G. Yudin’s anthropological ideas on human beings as agents who constantly change their own boundaries in the “zone of phase transitions.” The article focuses on the events taking place in the zone of phase transitions between humans and machines in eHealth. It is shown that for innovative practices related to digitalization and datafication in medicine, it is needed to rethink central bioethical concepts of personal autonomy and informed consent. In particular, the concept of broad or open informed consent is discussed, which allows the idea of moral responsibility in the field of biomedical technologies to be extended to events of uncertain future. The authors draw attention to the problems associated with the emergence of new autonomous subjects/agents (machines with artificial intelligence) in relationship between doctors and patients. The humanization of machines occurring in eHealth is accompanied by a counter trend – the formation of conceptions and practices of the quantified self. There emerges the practices of self-care and bio-power (M. Foucault) caused by the datafication and digitization of personality. The authors conclude that bioethics should proactively develop norms for the evolving interaction between doctor and patients.

This research investigates the semantics and the structure of the constructions with the verb eiti ‘to go’ extracted from the old Lithuanian written texts, dating back to the 16th century. It aims to examine the meanings and the structure of the constructions that contain the motion verb eiti ‘to go’ within their structure. There is a considerable body of research investigating various aspects of motion verbs in different languages of the world, including Lithuanian. However, no studies have so far targeted constructions with the verb eiti ‘to go’, found in the 16th century Lithuanian writings. The present study is based on the qualitative content analysis, quantitative analysis, and frame semantics methodology. The concordances of the Lithuanian texts have been filtered out from the Database of Old Writings digitalised by the Institute of the Lithuanian Language. The examples were taken from Martynas Mažvydas’ Katekizmas (MžK) and Forma krikštymo (MžF), Jonas Bretkūnas’ Biblija (BB), Giesmės Duchaunos (BG), Kancionalas (BKa) and Kolektos (BKo), Mikalojus Daukša’s Katekizmas (DK) and Postilė (DP).The frames of Motion, State, Law, Eternity, Service, Opposition, Law, etc., evoked by the selected constructions, were examined using the frame semantics (FrameNet Project). The research has shown that the current constructions with the motion verb eiti ‘to go’ can form the core of the mentioned frames. The observation that has emerged from this analysis is that some meanings of the analysed constructions are conserved in the current Lithuanian language while others have already disappeared. This work could be useful for historical linguists.

The purpose of this study is to investigate the interplay between government initiatives, public trust in government, and citizen engagement within the context of two distinct crisis scenarios: a global health crisis caused by the COVID-19 pandemic and an international security crisis caused by Russian aggression against Ukraine. A two-stage biennial survey methodology is used to collect quantitative data. In the first phase, which took place in the context of a global health crisis, an omnibus survey was conducted, involving a randomly selected sample of 3,175 respondents from three Baltic countries: Estonia (n = 1002), Latvia (n = 1017), and Lithuania (n = 1006). In the second stage, which took place in the context of an international security crisis, a random sample was carried out of 2026 respondents from two Baltic countries: Estonia (n = 1002) and Lithuania (n = 1024). The analysis examined causal relationships in political, rational, and social trust.The findings reveal that the relationship between trust in the government and government initiatives that foster political, rational, or emotional trust is stronger during international security crises than during health crises. This means that citizens perceive government behavior as more credible in the context of external security threats. Research on the interaction between government behavior and citizen participation is more nuanced than on public trust. In general, government initiatives have a greater impact on citizen participation than public trust in both crises. This highlights the positive impact of government initiatives in cooperation with the population. AcknowledgmentThe study is financed from the funds of the study-supporting project “Research on the Management of Security and Defense Institutions of Small States” (General Jonas Žemaitis Lithuanian Military Academy, 2020-12-17, No. V-828).

Modern bureaucratic competencies, such as creativity, innovative problem-solving, and critical thinking, have become essential in contemporary public management due to complex challenges in a wide range of areas, including the economy, social welfare, and the environment. This has led to a greater focus on developing these competencies, through innovative methods like creative problem-solving (CPS) in the training of public management specialists. The aim of this study is to identify specific competencies among public management professionals that can be cultivated through the CPS approach and to explore the critical conditions for its successful implementation. The analysis was conducted at the Military Academy of Lithuania, where CPS techniques have been consistently integrated into public management-related subjects for several years, forming a stable foundation for the in-depth investigation. First, the study examines Lithuania’s legal framework for public management and public management education to implement CPS. Second, a qualitative data analysis of open-ended feedback (n = 199) highlights practical application. The findings reveal that the Lithuanian legal context underscores the importance of fostering creativity and innovation among public managers. Furthermore, the practical integration of CPS into public management curricula promotes modern bureaucratic qualities such as teamwork, critical thinking, problem-solving, creativity, innovation, and leadership. However, effective CPS implementation requires additional curriculum time, a supportive and creative learning environment, and strong teacher and student commitment. These findings underscore CPS’s potential as a valuable tool for cultivating public management competencies. Acknowledgment The study is financed from the funds of the study-supporting project “Research on the Management of Security and Defense Institutions of Small States” (General Jonas Žemaitis Lithuanian Military Academy, 2020-12-17, No. V-828).

Abstract Structural rearrangements and in particular, gene fusions, are key mutational processes in bone and soft tissue tumors, used for both disease classification and as biomarkers. However, the mutational processes and rearrangement processes underlying many of these events remain poorly characterized. Recent data indicate that sarcomas show particularly high frequencies of complex rearrangement events, including patterns which do not fit those of known mutational mechanisms. As the largest whole genome sequencing (WGS) cohort of sarcomas to date, the Genomics England (GE) 100,000 Genomes project represents a unique dataset in which to profile these events. Structural variants (SVs) were identified in whole genome sequencing data for 978 samples from the Genomics England 100,000 Genomes Project using an optimized approach based on 5 specialized SV callers. SVs identified by at least 2 callers were filtered to retain only those which passed the quality filter, and to remove variants present in either matched germline samples or &gt;1% of a panel of normal variants. Chromothriptic events, extrachromosomal DNA (ecDNA) and genes enriched for SVs were identified using established algorithms. The prevalence of SVs varies across sarcoma, in keeping with previous reports, with particularly high rates observed in myxofibrosarcoma and liposarcoma. As described previously, liposarcomas showed the highest rates of chromothripsis. We have examined some tumor types at higher granularity than previously available, demonstrating directly that the rates of complex rearrangement events vary across subtypes. For example, chromothriptic events are identified in 100% of well-differentiated liposarcomas, but less than 10% of myxoid liposarcomas. Similarly, the presence of ecDNA varies by tumor type, with the novel observation of particularly high rates in angiosarcoma. Using these data, we have catalogued the rearrangement patterns generating canonical gene fusions in fusion-driven soft tissue tumor types. Despite more recent advances in histological classification, survival for patients with sarcoma has remained largely unchanged for 40 years. Characterization of the mutational processes underlying these rearrangements will shed light on the pathogenesis of these tumors. Citation Format: Sara Waise, Tom Lesluyes, Jonas Demeulemeester, Maxime Tarabichi, Adrienne Flanagan, Nischalan Pillay, Peter Van Loo. Illuminating the complex rearrangement landscape of sarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4337.

Swedish Literature as World Literature in the Nineteenth Century. Top Selling Novels by Women Writers So far, Swedish literary history has been the construction of a nation’s cultural heritage based on certain authorships. This most certainly was the case when the history of the Swedish nineteenth-century novel was written. In textbooks, the important writers before Strindberg and Lagerlöf are Carl Jonas Love Almqvist and Viktor Rydberg. Sometimes a couple of female novelists are included, such as Fredrika Bremer and Emilie Flygare-Carlén. The actual circulation of Swedish novels in translation shows another picture. While Bremer and Flygare-Carlén, together with Marie Sophie Schwartz, were very popular novelists in both Europe and the United States, Almqvist’s and Rydberg’s novels reached very few readers outside of Scandinavia. This article aims to examine the export of Swedish novels in the nineteenth century. Statistics based on the SWED database, constructed in connection to the research project Swedish Women Writers on Export in the Nineteenth Century, is used to describe the distribution of Swedish novels across borders and their translation into different target languages. Similarities and dissimilarities in distribution and reception will be discussed, as well as some of the reasons behind these differences. The number of translated titles, as well as the transcultural circulation of the three most translated and top-selling novelists, Bremer, Flygare-Carlén and Schwartz, are compared to the circulation of Almqvist’s and Rydberg’s translated works. Based on these comparisons, it becomes obvious that if the history of Swedish literature were written from a transcultural perspective based on the contemporary audience’s choice of literary works and writers, it would look very different from the nation-based literary history of today. For example, Almqvist and Rydberg would be edged out by female novelists such as Bremer,Flygare-Carlén, and Schwartz.

Aktualni proces fragmentiranja etike na brojne posebne etike autor u polazištu članka ocjenjuje kao proces destruiranja etike kao filozofske discipline. To dovodi u vezu s povijesnim neuspjehom etike koja zbog kategorijalnih ograničenja nije bila u stanju odgovoriti na izazove uznapredovale znanstveno-tehničke civilizacije, uslijed čega je nastao »etički vakuum« (H. Jonas). U reakciji na etički vakuum nastale su brojne etičke inicijative koje autor, prema učincima na rehabilitaciju uloge tradicionalne etike i na stvaranje novog orijentacijskog okvira, razvrstava na destruktivnu i produktivnu liniju. Na produktivnoj crti prevladavanja etičkog vakuuma nastala je bioetika koja je, zajedno s drugim etičkim projektima, stvorila novo orijentacijsko ozračje koje autor naziva »novom etičkom kulturom«. Na destruktivnoj liniji, uz inflaciju posebnih etika, pojavio se i poseban oblik destrukcije u vidu implantiranja »primijenjene etike«, koju autor označava kao besmislen pojam, u tkivo tradicionalne etike. Potom autor izlaže tri glavna problema primijenjene etike. Prvi je glavni problem supstancijalne naravi i sastoji se u tome što ona nema i u načelu ne može imati neupitne norme kao objekt primjene. Drugi je glavni problem metodološke naravi i sastoji se u neprimjerenosti i neprihvaćenosti deduktivizma kao modela primjenjivanja etičkih normi na praksu. Treći je glavni problem uporabne naravi i sastoji se u razvijanju mita o praktičnosti primijenjene etike. Autor izvodi zaključak da primijenjena etika nije ni etički koncept ni etički projekt nego marketinški 'brend' koji se na etičkom planu ispostavlja kao besmisao. U poanti članka autor tvrdi da je primijenjena etika postala institucijom etičkog apsurda u onom trenutku kada je kao isprazna marketinška etiketa preuzela prazno mjesto objekta primjene i ulogu opće etike za nepovezani i nedefinirani konglomerat posebnih etika koje su pretvorene u njene grane.

Aktualni proces fragmentiranja etike na brojne posebne etike autor u polazištu članka ocjenjuje kao proces destruiranja etike kao filozofske discipline. To dovodi u vezu s povijesnim neuspjehom etike koja zbog kategorijalnih ograničenja nije bila u stanju odgovoriti na izazove uznapredovale znanstveno-tehničke civilizacije, uslijed čega je nastao »etički vakuum« (H. Jonas). U reakciji na etički vakuum nastale su brojne etičke inicijative koje autor, prema učincima na rehabilitaciju uloge tradicionalne etike i na stvaranje novog orijentacijskog okvira, razvrstava na destruktivnu i produktivnu liniju. Na produktivnoj crti prevladavanja etičkog vakuuma nastala je bioetika koja je, zajedno s drugim etičkim projektima, stvorila novo orijentacijsko ozračje koje autor naziva »novom etičkom kulturom«. Na destruktivnoj liniji, uz inflaciju posebnih etika, pojavio se i poseban oblik destrukcije u vidu implantiranja »primijenjene etike«, koju autor označava kao besmislen pojam, u tkivo tradicionalne etike. Potom autor izlaže tri glavna problema primijenjene etike. Prvi je glavni problem supstancijalne naravi i sastoji se u tome što ona nema i u načelu ne može imati neupitne norme kao objekt primjene. Drugi je glavni problem metodološke naravi i sastoji se u neprimjerenosti i neprihvaćenosti deduktivizma kao modela primjenjivanja etičkih normi na praksu. Treći je glavni problem uporabne naravi i sastoji se u razvijanju mita o praktičnosti primijenjene etike. Autor izvodi zaključak da primijenjena etika nije ni etički koncept ni etički projekt nego marketinški brend koji se na etičkom planu ispostavlja kao besmisao. U poanti članka autor tvrdi da je primijenjena etika postala institucijom etičkog apsurda u onom trenutku kada je kao isprazna marketinška etiketa preuzela prazno mjesto objekta primjene i ulogu opće etike za nepovezani i nedefinirani konglomerat posebnih etika koje su pretvorene u njene grane.

As Manuel de Solà-Morales noted, <em>urbanity</em> relies on the variety and quality of relations between things, materials and human beings.<strong><em> </em></strong>Considered as such, how are we to achieve an<em> underground </em>urbanity?<strong><em> </em></strong>This paper seeks to address this question through a focussed reading of a number of European urban projects from the 20^th century; all of which put special care into ensuring the quality of their subterranean passageways.<strong><em> </em></strong>We begin with the<em> carrefour à giration,</em> which was designed by Eugène<em> </em>Hénard in 1906, in order to identify four fundamental attributes of this kind of urbanity:<em> legibility, spatiality, accessibility </em>and<em> </em><em>activity</em>.<strong><em> </em></strong>We then continue with a qualitative analysis of the 1933 <em>Blå Bodarna</em> passageway designed by Tage William-Olsson and Holger Blom in Slussen (Stockholm). Looking ahead some decades later, the sequence of passages under the Vienna Ring, built during the mayoralty of Franz J. Jonas, provides a good example of how fundamental the connectivity to the underground public transport system was to the success of these spaces.<strong><em> </em></strong>Finally, the article closes with a review of those underground places found in Santiago Calatrava’s Stadelhofen Station and the Stationsplein by Manuel de Solà-Morales: from the <em>carrefour à étages multiples </em>to the ‘<em>inner </em>street’.

Abstract Genomic rearrangements are key mutational processes in a number of bone and soft tissue tumors (sarcomas). These events are used for both disease classification and as prognostic and predictive biomarkers. However, the rearrangement architecture and mutational processes giving rise to many of these events remain poorly characterized. Recent data indicate that sarcomas show particularly high frequencies of complex structural rearrangements, including patterns which do not fit those of known mutational mechanisms. As the largest whole genome sequencing (WGS) dataset of sarcomas to date, the Genomics England (GE) 100,000 Genomes Project represents a unique cohort in which to examine these events. Structural variants (SVs) were identified using five SV callers (Manta, Delly, LUMPY, SvABA and GRIDSS) in WGS data from 1330 GE samples. SVs were filtered to retain only those passing the quality filter, and to remove variants present in either matched germline samples or &gt;1% of a panel of normal variants. Caller performance was evaluated by comparison of distances between SV and copy number call breakpoints generated by Battenberg. SVs identified by at least two callers were taken forward as high-quality calls. Chromothriptic events, extrachromosomal DNA (ecDNA) and breakage-fusion-bridges were identified using established algorithms. In keeping with previous data, the prevalence of structural variants varies by tumor type, with particularly high numbers of SVs observed in liposarcoma and osteosarcoma. Many tumor types included notable outlier samples; these were more likely to show evidence of chromothripsis, as identified by a dedicated chromothripsis caller. Liposarcomas show the highest frequency of chromothripsis, as described previously. In addition, we have examined some tumor types at higher granularity than previously available, demonstrating directly that the prevalence of chromothripsis varies by histological subtype. For example, chromothriptic events are identified in 100% of well-differentiated liposarcomas, but less than 10% of myxoid liposarcomas. Similarly, the presence of ecDNA varies by tumor type, with the novel observation of particularly high rates in angiosarcoma. Despite recent advances in histological classification, the survival for patients with sarcoma has remained largely static for over 40 years. Determination of the mutational processes generating these rearrangements will shed light on the pathogenesis of these tumors. Citation Format: Sara Waise, Tom Lesluyes, Jonas Demeulemeester, Maxime Tarabichi, Sarcoma Genomics England Clinical Interpretation Partnership, Nischalan Pillay, Adrienne M. Flanagan, Peter Van Loo. Profiling the complex rearrangement landscape of sarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2286.

Siekiant padidinti skaitmeninimo veiklų valdymo efektyvumą, Lietuvos kultūros paveldo skaitmeninimo, skaitmeninio turinio saugojimo ir prieigos strategijoje (2009–2013) buvo numatyta sukurti kultūros paveldo skaitmeninimo stebėsenos sistemą ir nuolat vykdyti Lietuvos kultūros paveldo skaitmeninio stebėsenąbei vertinimą. Straipsnyje supažindinama su skaitmeninimo stebėsenos sistemos koncepciniu modeliu, grindžiamu pagrindiniais sistemų teorijos principais bei sisteminiu požiūriu paremta vertinimo teorija. Koncepcinis modelis integruoja skaitmeninimo stebėsenos sistemos apibrėžties ir jos paskirties aprašymą, modelio kūrimo principus ir metodologiją, stebėsenos rodiklių pasirinkimą bei jų aprobavimo rezultatus.Pagrindiniai žodžiai: koncepcinis modelis, metodologija, stebėsenos rodikliai, skaitmeninimas, skaitmeninimo stebėsenos sistema.A conceptual model of the digitization monitoring system: the Lithuanian experienceRegina Varnienė-Janssen, Jonas Juškys, Neringa Račkauskaitė Summary The article presents a conceptual model for a digi­tization monitoring system, which will be used as the basis for implementing a digitization monitor­ing system in Lithuania. The conceptual model, which is based on the systems theory and evalu­ation theory principles, involves the description of the digitization monitoring system and its scope, principles for the creation of the model, and the choice of the monitoring indicators and their ap­probation results. The key factor influencing the creation of such a system is digitization performed by numerous independent institutions subordinate to different ministries. The creation of a system for monitoring the digitization of cultural heritage objects aims at preventing the duplication of digitization activities, ensuring an effective use of technical equipment and software for performing the digitization of cul­tural heritage objects, applying the best practice of coordinated digitization activities and appropriate standards and formats, as well as a convenient and prompt access to information and statistical data on the results of the activities being performed. The digitization monitoring system is created in line with recommendations of the Feasibility Study for the Creation of a Digitization Monitoring Sys­tem, prepared on demand of the Martynas Mažvydas National Library of Lithuania, and requirements of the Specification for the Creation of Software for a Digitization Monitoring System in which, as one of its main requirements, was the creation of a manual of digitization monitoring. The article builds on the above-mentioned feasibility study. The rationale for the creation of a digitization monitoring system conforms with this system’s the­ory principles which require that the modelling of a system activities should involve an analysis of the input, process, and output, as well as feedback evalu­ation. The conceptual model of digitization monitor­ing is based on the following principles: • the system’s activity is shaped and organized by a holistic evaluation of the existing ap­proaches to the creation of such systems; real­ization that a system aggregates multiple ele­ments (interacting institutions and their units) which interact among themselves and with the environment; and abstraction of all elements and their interactions and merging them into a conceptual model. • indicators within a digitization monitoring system are determined through defining the existing state and problems of digitization ac­tivities, investigating the monitoring demands and requirements for such systems, and evalu­ating the conceptual model of this system, based on the results of a discussion. • The main criteria for selecting the indicators of digitization monitoring are clarity, rel­evance, efficiency, and possibility to monitor. A conceptual model based on the holistic appro­ach allows designing a system able to monitor digiti­zation activity results, standards and formats of me­tadata and access, identification and distribution of tasks, and tracking implementation of goals. It also enables institutions performing digitization activities to acquire information on digitization initiatives and current and (or) intended projects, on resources held by other institutions and the characteristics of these resources, on trainings, conferences or other events related to digitization that are on the agenda, also, it enables to successfully monitor and keep under re­view the realization of initiatives, programmes, and strategies, to facilitate a quality evaluation and per­formance improvement, to assess the risks, to im­prove supervision activities, efficiency, and manage­ment processes, to prepare accounts, to substantiate resources and expenses, to increase performance im­pact, and to monitor digitization initiatives as well as current and (or) intended projects.

Abstract Clinical problem. Ductal Carcinoma in Situ (DCIS) is a potential precursor for invasive breast cancer (IBC). Therefore, DCIS is currently treated with surgical excision, often supplemented with radiotherapy to prevent progression to ipsilateral IBC (iIBC). However, many DCIS lesions will never do so. Estimating the risk of progression is a grand challenge, as neither the histopathological grade of the DCIS lesion nor other biological markers are conclusively associated with the disease outcome. Aim. We aimed to develop a deep-learning based pipeline for estimating the risk of iIBC recurrence following DCIS using a dataset of 235 H&E-stained whole-slide images (WSIs) of the primary DCIS lesions with corresponding 10-year follow up metadata of DCIS recurrence collected at the Netherlands Cancer Institute. The patients included in our dataset did not receive radiotherapy and experienced recurrence in 167 of the cases. Results. We developed a two-step pipeline that is able to find predictive features for 10-year iIBC prediction. First, tissue regions on WSIs were divided into equally sized tiles. Mammary ducts were detected in the tiles using a RetinaNet with ResNet101 backbone that was implemented in Detectron2 and pre-trained on ImageNet. Selecting only tiles containing ducts served to reduce the input dimensionality of typically giga-pixel WSIs for the second step. Here, DCIS recurrence was predicted by a weakly-supervised multi-instance learning (MIL) classification model where the label of the WSI was determined by average weighting of duct labels. The performance of this model was enhanced by pre-training it with SimCLR, a self-supervised learning method, on image data from the histopathology domain. Our proposed model achieved an AUC of .93 ± .005, with a sensitivity of .83 ± .27 and a specificity of .85± .09. These results show that the model was able to correctly distinguish patients with low subsequent IBC-risk from those with a substantially higher risk. An active research pursuit of our group is now to develop a model which is able to predict iIBC progression for patients treated with radiotherapy. This poses additional challenges to the model, as the effect of radiotherapy, as well as disease outcome must be predicted. Conclusion and impact. Our method opens up an avenue for identifying biologically relevant features for estimating DCIS progression risk into invasive breast cancer. This knowledge may be used for appropriately choosing a personalized DCIS management option for patients - which may be active surveillance rather than surgical removal of the lesion. JW and JT were equal senior co-authors on this project. This work was supported by Cancer Research UK and by KWF Dutch Cancer Society (ref.C38317/A24043) Citation Format: Shannon Doyle, Francesco Dal Canton, Timo Koostra, Maartje van Seijen, Emilie Groen, Efstratios Gavves, Hugo Horlings, Esther Lips, Jelle Wesseling, Jonas Teuwen, Grand Challenge PRECISION Consortium. Deep learning applied on resection specimen tissue slides of ‘pure’ ductal carcinoma in situ predicts ipsilateral invasive breast cancer recurrence [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD11-03.

BackgroundRheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS) [1] is used to manually assess severity of disease activity and monitor treatment response, but it is dependent on observer variability and is time-consuming. Deep learning techniques have the potential to improve the reproducibility and efficiency of RAMRIS scoring by automating the analysis of hand MRI scans, however, there are limited data on an automated assessment approach.ObjectivesTo investigate whether a deep neural network (DNN) can be trained to automatically detect erosion, synovitis, and oedema in RA patients using hand MRI scans and RAMRIS.MethodsWe used 1,5 Tesla hand MRI (Siemens Magnetom Vida and Aera) from the BARE BONE trial, a prospective, single-arm, interventional, open-label, phase 4 trial (EUDRACT 2018-001164-32) in which RA patients were treated with baricitinib (4 mg/day) for 48 weeks. One of the objectives of BARE BONE was to assess the effect of baricitinib on joint damage and synovial inflammation. Participants of BARE BONE received hand MRI at week 0, 24, 48 following a standardized scanning protocol [2]. All images were scored according to RAMRIS. DNNs were applied on coronal T1 (pre/post contrast enhancement) and T2 MR images. 3-D landmarks for each location for RAMRIS scoring were identified and a region of interest (ROI) around each landmark was extracted to train a DNN. Three separate DNNs were trained, one for each of the RAMRIS subcomponents (erosion, synovitis, oedema). Each DNN is based on a ResNet-3D [3] architecture that was pretrained on a video classification task [4]. The networks were trained to predict the severity scores of each disease characteristic into three classes ranging from 0 (no pathological change) to 2 (high disease burden). The performance of the DNNs was evaluated using the area under the receiver operating characteristic curve (AUROC) and the area under the precision-recall curve (PR-AUC). Three-fold cross-validation were used and the network performance on a hold-out test set was evaluated.ResultsIn total, we obtained 212 coronal MR images with both T1 and T2 weighting from 30 RA patients (24 woman/6 men, age 53.5±12.6 years, disease duration 4.3±4.4 years). The overall RAMRIS score decreased from 20.6 (CI95% 14.4 to 27.8) to 18.3 (CI95% 11.5 to 26.5) at week 48. For the evaluation of erosions and oedema, 23 landmarks respectively were used per hand, and 7 landmarks for synovitis. In total 4608 landmarks for erosion and oedema were available, and for synovitis 1152 landmarks. The AUROC for predicting erosions was 86±2% with a PR-AUC of 83±4%. For the prediction of oedema the AUROC was 78±14% and PR-AUC was 83%±10%. Despite a low number of ROI for synovitis scoring, the respective AUROC was 60±4% and PR-AUC was of 69±3%.ConclusionThis proof-of-concept study demonstrated that fully automated extraction of synovitis, bone oedema, and erosion is feasible. In the future, our deep neural network approach may help to automatically assess MRI data of the hand in routine clinical practice and trials with high accuracy while keeping costs and human resources manageable.References[1]Østergaard M et al. The Journal of Rheumatology 2017.[2]Kemenes S et al. Annals of the Rheumatic Diseases 2022; 81:1320-1321.[3]Hara K et al. arXiv:1711.09577, 2018.[4]Kay W et al.https://arxiv.org/pdf/1705.06950.Figure 1.Neural network pipeline. Region of interests required required for RAMRIS scoring are extracted from hand MR images. All region of interests required are fed into a ResNet 3D to detect erosion, synovitis and bone oedema, respectively.AcknowledgementsThe study was supported by Lilly Deutschland GmbH and the DFG (FOR2886 PANDORA, CRC1181, CRC1483 EmpkinS). Additional funding was received by BMBF (project MASCARA), the ERC Synergy grant 4D Nanoscope, the IMI funded project RTCure, the Emerging Fields Initiative MIRACLE of the FAU Erlangen-Nürnberg. M.S., J.Q. and K.B. gratefully acknowledge support by d.hip campus - Bavarian aim. Infrastructural and hardware support was provided by the d.hip Digital Health Innovation Platform.Disclosure of InterestsMaja Schlereth: None declared, Arnd Kleyer Consultant of: Received consulting fees from Lilly Deutschland GmbH., Jonas Utz: None declared, Lukas Folle: None declared, Sara Bayat Consultant of: Received consulting fees from Lilly Deutschland GmbH., Filippo Fagni: None declared, Ioanna Minopoulou: None declared, Koray Tascilar Consultant of: Received consulting fees from Lilly Deutschland GmbH., Jule Taubmann: None declared, Michael Uder: None declared, Tobias Heimann: None declared, Jingna Qiu: None declared, Georg Schett: None declared, Katharina Breininger: None declared, David Simon Consultant of: Received consulting fees from Lilly Deutschland GmbH.

BackgroundThe experience of art offers an emerging field in healthcare staff development, much of which is appropriate to the practice of palliative care. The workings of aesthetic learning interventions such as interactive theatre in relation to palliative and end of-life care staff development programmes are widely uncharted.AimTo investigate the use of aesthetic learning interventions used in palliative and end-of-life care staff development programmes.DesignScoping review.Data sourcesPublished literature from 1997 to 2015, MEDLINE, CINAHL and Applied Social Sciences Index and Abstracts, key journals and citation tracking.ResultsThe review included 138 studies containing 60 types of art. Studies explored palliative care scenarios from a safe distance. Learning from art as experience involved the amalgamation of action, emotion and meaning. Art forms were used to transport healthcare professionals into an aesthetic learning experience that could be reflected in the lived experience of healthcare practice. The proposed learning included the development of practical and technical skills; empathy and compassion; awareness of self; awareness of others and the wider narrative of illness; and personal development.ConclusionAesthetic learning interventions might be helpful in the delivery of palliative care staff development programmes by offering another dimension to the learning experience. As researchers continue to find solutions to understanding the efficacy of such interventions, we argue that evaluating the contextual factors, including the interplay between the experience of the programme and its impact on the healthcare professional, will help identify how the programmes work and thus how they can contribute to improvements in palliative care.References. Economist Intelligence Unit. 2015Quality of Death Index Ranking palliative care across the world. https://www.eiuperspectives.economist.com/healthcare/2015-quality-death-index, (2013 accessed 09/01/2017). World Health Organisation.WHO Definition of Palliative Care. Geneva: WHO. 2009.. Department of Health.Equity and excellence: Liberating the NHS. London: The Stationery Office Ltd. 2010.. Neuberger J.More care, less pathway: a review of the Liverpool care pathwayhttps://www.gov.uk/government/uploads/system/uploads/attachment_data/file/212450/Liverpool_Care_Pathway.pdf,(2013, accessed 09/12/2015). The National Council for Palliative Care. Commissioning Guidance for Specialist Palliative Care: Helping to deliver commissioning objectives.http://www.ncpc.org.uk/sites/default/files/CommissioningGuidanceforSpecialistPalliativeCare.pdf, (2012, accessed 15/12/2015). Leadership Alliance for the Care of Dying People.One Chance to get it Right.https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/323188/One_chance_to_get_it_right.pdf, (2014accessed 15/12/2015). Cavaye J and Watts J. An Integrated Literature Review of Death Education in Pre-Registration Nursing Curricula: Key Themes, International Journal of Palliative Care, 2014, Article ID 564619, 19 pages. Gibbins J, McCoubrie R. Forbes K. Why are newly qualified doctors unprepared to care for patients at the end of life?Medical Education2011; 45(4): 389–399.. Gillan PC, van der Riet PJ and Jeong S. End of life care education, past and present: A review of the literature.Nurse Education Today2014; 34(3): 331–342.. Holms N, Milligan S and Kydd A. ‘A study of the lived experiences of registered nurses who have provided end-of-life care within an intensive care unit’,International Journal Of Palliative Nursing2014; 20(11): 549-556.. Levack P. Palliation and the caring hospital – filling the gap.Journal of the Royal College of Physicians Edinburgh2014; 44: 98–102.. Parliamentary and Health Service Ombudsman.Dying without dignity.http://www.ombudsman.org.uk/reports-and-consultations/reports/health/dying-without-dignity#_ftn1, (2015, accessed 15/12/2015).. NHS England.Actions for End of Life Care: 2014-16. https://www.england.nhs.uk/wp-content/uploads/2014/11/actions-eolc.pdf, (2014, accessed 15/12/2015).. Thun MJ, DeLancey JO, Centre MM, Jemal A, and Ward E M. The global burden of cancer: priorities for prevention.Carcinogenesis2010;31(1), 100–110.. Crawford P, Brown B, Baker, C, Tishler, V and Abrams B.Health Humanities. London: Palgrave Macmillan, 2015.. Tolstoy N. 1897.What is Art? [Qu est-ce que l' art?]. Paris: Gallimard, 1971.. Chinn PL, Maeve MK, and Bostick C. Aesthetic inquiry and the art of nursing.Scholarly Inquiry for Nursing Practice1997; 11: 83–96.. Goldenberg G. Sarah Sheets Cook: the invisible nurse.The Academic Nurse1999; 16(1): 26–28.. Buckley J. Massage and aromatherapy massage: nursing art and science.International Journal of Palliative Nursing2002; 8: 276–280.. Gramling KL. Ice chips and hope: the coach’s story of caring art.International Journal for Human Caring2004; 8(2): 62–64.. Gramling KL. Sarah’s story of nursing artistry: they do it with joy.Journal of Holistic Nursing2006; 24: 140–142.. Ryan J. Aesthetic physical caring: valuing the visible.Nursing in Critical Care2004; 9: 181–187.. Mendes IAC. Cultivating the art of service.Revista Latino Americana de Enfermagem2005; 13(2): 135.. Wyngaarden JB and Smith LH.Cecil textbook of medicine.Philadelphia: WB Saunders, 1985.. Saunders, J. The practice of clinical medicine as an art and as a science.Med Humanities2000; 26:18-22.. Egnew, T. The Art of Medicine: Seven Skills That Promote Mastery.FamilyPractice Management.2014; 21(4): 25-30.. Funch BS. The psychology of art appreciation. Copenhagen: Museum Tusculanum Press, 1997.Perry M, Maffulli N, Willson S and Morrissey D. The effectiveness of arts-based interventions in medical education: a literature review. Medical Education2011; 45(2): 141-148.. Wilson C, Bungay H, Munn-Giddings, C and Boyce M. Healthcare professionals’ perceptions of the value and impact of the arts in healthcare settings: A critical review of the literature.International Journal of Nursing Studies2016; 56: 90-101.. Ousager J and Johannessen H. Humanities in undergraduate Medical Education: A Literature Review. Academic Medicine2010; 85(6): 988-98.. Fairbrother G, Cashin A, Mekki TE, Graham I and McCormack B. Is it possible to bring the emancipatory practice development and evidence-based practice agendas together in nursing and midwifery?FoNS 2015 International Practice Development Journal2015; 5(1) [4].. Levac D, Colquhoun H and O’Brien KK. Scoping studies: advancing the methodology. Implementation Science2010; 5: 1–9.. Arksey H and O’Malley L. Scoping studies: towards a methodological framework.International Journal of Social Research Methodology: Theory & Practice2005; 8: 19-32.. Rumrill P, Fitzgerald S and Merchant W. Using scoping literature reviews as a means of understanding and interpreting existing literature.Work2010; 35: 399-404.. Grant M and Booth A: A typology of reviews: an analysis of 14 review types and associated methodologies.Health Info Libr J2009, 26: 91-108.. Brien S, Lorenzetti D, Lewis S, Kennedy J and Ghali W: Overview of a formal scoping review on health system report cards.Implement Sci2010, 5:2.. Armstrong R, Hall BJ, Doyle J and Waters E. Scoping the scope of a cochrane review.Journal of Public Health2011; 33: 147–150.. Daudt HM, Van Mossel C and Scott SJ. Enhancing the scoping study methodology: a large, inter-professional team’s experience with Arksey and O’Malley’s framework.BMC Medical Research Methodology2013; 13: 48.. Braun, V. and Clarke, V. Using thematic analysis in psychology. Qualitative Research in Psychology 2006; 3 (2): 77–101.. RefWorks.RefWorks your online research management, writing and collaboration tool,2009.. Bettany-Saltikov J.How to do a systematic literature review in nursing: a step-by-step guide. Maidenhead: McGraw-Hill/Open University Press, 2012.. Davis K. Drey N. and Gould D. What are scoping studies? A review of the nursing literature.Int J Nurs Stud2009; 46(10): 1386-400.. Pawson R. Evidence-based policy: in search of a method.Evaluation2002; 8(2): 157-181.. Duffin C. “Raising Awareness to Support People with Dementia in Hospital”,Nursing Older People2013; 25(5): 14–17.. Skye EP, Wagenschutz H, Steiger JA and Kumagai AK. Use of interactive theatre and role play to develop medical students’ skills in breaking bad news,Journal of Cancer Education2014; 29(4): 704–708.. Baer AN, Freer, JP, Milling DA, Potter, WR, Ruchlin H and Zinnerstrom KH Breaking bad news: use of cancer survivors in role-playing exercises,Journal of palliative medicine 200811(6): 885–892.. Tait GR and Hodges BD Residents learning from a narrative experience with dying patients: a qualitative study.Advances in Health Sciences Education2013; 18(4): 727–743.. Jones A. Death, poetry, psychotherapy and clinical supervision (the contribution of psychodynamic psychotherapy to palliative care nursing),Journal of advanced nursing1997; 25(2): 238–244.. Shapiro J, Hunt L. All the world’s a stage: the use of theatrical performance in medical education.Med Educ2003; 37(10): 922–7. Robinson S. Holistic health promotion: Putting the art into nurse education.Nurse Education in Practice2007; 7(3): 173--180.. Shapiro J, and Cho B. Medical Readers’ Theatre: Relevance to Geriatrics Medical Education,Gerontology & Geriatrics Education2011; 32(4): 350--366.. Durgahee T. Reflective practice: nursing ethics through story telling”,Nursing ethics1997; 4(2): 135–146.. Reilly J, Trial J, Piver D and Schaff P. Using Theatre to Increase Empathy Training in Medical Students,Journal for Learning through the Arts2012; 8(1).. Inske ep S and Lisco S. Alternative Clinical Nursing Experience in an Art Gallery.Nurse Educator2001; 26(3): 117--119.. Thompson T, van de Klee D, Lamont-Robinson, C and Duffin W. Out of Our Heads! Four perspectives on the curation of an on-line exhibition of medically themed artwork by UK medical undergraduates”,Medical Education Online 2010; 15.. Hickey D, Doyle C, Quinn S, O’Driscoll P, Patience D, Chittick K and Cliverd A. Catching’ the concept of spiritual care: implementation of an education programme”,International journal of palliative nursing2008; 14(8): 396–400.. Deloney LA and Graham CJ. Wit: using drama to teach first-year medical students about empathy and compassion,Teaching & Learning in MedicineCatching’ the concept of spiritual care: implementation of an education 15(4): 247–251.. Hodges HF, Keeley AC and Grier EC. Masterworks of art and chronic illness experiences in the elderly,Journal of advanced nursing2001; 36(3) 389–398.. Marchand L and Kushner K. Death pronouncements: using the teachable moment in end-of-life care residency training,Journal of palliative medicine2004; 7(1) 80–84.. Beach WA, Buller MK, Dozier DM, Bulle DB and Gutzmer K. The Conversations About Cancer (CAC) Project: Assessing Feasibility and Audience Impacts From Viewing The Cancer Play,Health communication2014; 29(5): 462–472.. Begley A, Glackin M and Henry R. Tolstoy, stories, and facilitating insight in end of life care: Exploring ethics through vicarious experience,Nurse Education today2011; 31(5): 516–520.. Kumagai AK. Perspective: Acts of Interpretation: A Philosophical Approach to Using Creative Arts in Medical Education,Academic Medicine2012; 87(8): 1138--1134.. Özcan NK, Bilgin H and Eracar N. The Use of Expressive Methods for Developing Empathic Skills,Issues in Mental Health Nursing2011; 32(2): 131–136.. Tuxbury J, McCauley P and Lement W. Nursing and Theatre Collaborate: An End-of-Life Simulation Using Forum Theatre,Journal of Nursing Education,2012; 51(8) 462–5.. Yalden J, McCormack B, O’Connor, M and Hardy S, Transforming end of life care using practice development: an arts-informed approach in residential aged care,International Practice Development Journal2013; 3(2).. Sklar DP, Doezema D, McLaughlin S and Helitzer D. Teaching communications and professionalism through writing and humanities: reflections of ten years of experience,Academic Emergency Medicine2002; 9(11): 1360–1364.. Sperlazza E and Cangelosi PR. The Power of Pretend: Using Simulation to Teach End-of-Life Care,Nurse Educator2009; 34(6): 276--280.. Gillis C. “Seeing the difference”: An interdisciplinary approach to death, dying, humanities, and medicine.Journal of Medical Humanities2006;27(2): 105–115.. Donovan T and Mercer D. Onward in my journey: preparing nurses for a new age of cancer care,Cancer nursing2003; 26(5) 400–404.. Fogarty CT. Fifty-five word stories: “small jewels” for personal reflection and teaching,Family medicine2010; 42(6): 400–402.. Foster W and Freeman E. Poetry in general practice education: perceptions of learners,Family Practice2008;25(4) 294–303.. Lillyman S, Gutteridge R and Berridge P. Using a storyboarding technique in the classroom to address end of life experiences in practice and engage student nurses in deeper reflection,Nurse Education in Practice2011; 11(3): 179–185.. Frei J, Alvarez S and Alexander M. Ways of Seeing: Using the Visual Arts in Nursing Education,Journal of Nursing Education2010; 49(12): 672--676.. Sherman DW, Matzo ML, Pitorak E, Ferrell BR and Malloy P. Preparation and care at the time of death: content of the ELNEC curriculum and teaching strategies,Journal for Nurses in Staff Development2005; 21(3): 93–102.. Franklin M. Acting on dilemmas in palliative care,Nursing times2001; 97(49): 37–38.. Epner DE and Baile WF. Difficult conversations: teaching medical oncology trainees communication skills one hour at a time,Academic Medicine2014; 89(4): 578–584.. Shannon SE, Long-Sutehall T and Coombs M. Conversations in end-of-life care: communication tools for critical care practitioners,Nursing in critical care.2011; 16(3): 124–130.. Deci EL and Ryan RM.Intrinsic motivation and self-determination in human behaviour. New York: Plenum Press, 1985.. Wee B, Hillier R, Coles C, Mountford B, Sheldon F and Turner P. Palliative care: a suitable setting for undergraduate interprofessional education,Palliative Medicine2001; 15: 187–492.. Meng AL and Sullivan J. Interactive theatre: an innovative conflict resolution teaching methodology,Journal for Nurses in Staff Development2011; 27(2): 65–68.. Salas R, Steele K, Lin A, Loe C, Gauna L and Jafar-Nejad P. Playback Theatre as a tool to enhance communication in medical education.Medical Education Online2013; 18(10).. Jonas-Simpson CF, Pilkington B, MacDonald C and McMahon E. Experiences of Grieving When There Is a Perinatal Death,Sage open2013.. Razavi D, Delvaux N, Marchal S, Durieux JF, Farvacques C, Dubus L and Hogenraad R. Does training increase the use of more emotionally laden words by nurses when talking with cancer patients? A randomised study,Br J Cancer2002; 87(1): 1–7.. Twigg R and Lynn M, Teaching End-of-Life Care Via a Hybrid Simulation Approach Simulation Approac,Journal of Hospice & Palliative Nursing2012; 14(5): 374–379.. Baile WF, Kudelka AP, Beale EA, Glober GA, Myers EG, Greisinger AJ, Bast RC, Goldstein MG, Novack D and Lenzi R. Communication skills training in oncology. Description and preliminary outcomes of workshops on breaking bad news and managing patient reactions to illness,Cancer1999; 86(5): 887–897.. Wilkinson S, Perry BK and Linsell L. Effectiveness of a three-day communication skills course in changing nurses’ communication skills with cancer/palliative care patients: randomised controlled trial,Palliative medicine2008; 22: 365–75.