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Trilar, Jure, Veronika Zavratnik, Vid Čermelj, Barbara Hrast, Andrej Kos und Emilija Stojmenova Duh. „Rethinking Family-Centred Design Approach Towards Creating Digital Products and Services“. Sensors 19, Nr. 5 (11.03.2019): 1232. http://dx.doi.org/10.3390/s19051232.
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This article provides further study of a family-centred design approach model established in previous studies, which aims to correspond to the limitations and needs of modern families using information and communication technology (ICT) solutions for common activities, communication and organisation of family time. The ambition is to systematically define and design features (functionalities) of a prototype solution that connects family members; provides proper communication; promotes active quality family time, active life, a health-friendly lifestyle and well-being; and uses various sensor- and user-based data sources through a smart city ecosystem platform. The original approach model was applied in designing the MyFamily progressive web application prototype solution as part of the EkoSmart: Active Living and Well-Being Project (RRP3) funded by the Republic of Slovenia and the European Regional Development Fund Investing in Your Future program. Extensive testing of the prototype solution used and the triangulation method used within thematic analysis for user interviews provide new insights and proposals for the change of the family-centred design approach model in the form of distinct developmental goals narrative for each generation to enhance motivation and relevance of content to different generations of users of such digital solutions.
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Muthohar, Sofa, Fatah Syukur und Mahfud Junaedi. „PEMIKIRAN PENDIDIKAN PROGRESIF IVAN ILICH DALAM PERSPEKTIF FILSAFAT PENDIDIKAN ISLAM DI ERA MILLENIAL“. el-Tarbawi 13, Nr. 1 (25.01.2020): 1–22. http://dx.doi.org/10.20885/tarbawi.vol13.iss1.art1.
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This study discusses Ivan Illich’s progressive ideas from the perspective of Islamic Education Philosophy in the millennial era. This study uses a qualitative library research approach and uses content analysis. The results of this study indicate that there are several principles of learning from Ivan Illich that are in line with Islamic Education Philosophy. Firstly, the meaning of learning as knowledge sharing activities is not a school commodity. Secondly, there is equality of learning rights and without discrimination. While the principles that are considered unsuitable include two things. Firstly, the goal of Islamic education is to make people of good morals (akhlaqul karimah), while the learning objective of Ivan Illich is to realize social equality. Secondly, according to Ivan Illich, the concept of a perfect human being is human with full of hope based on effort and negates mercy (epimetheus), whereas, in Islam, a perfect person is a person of noble character (ulul albab). As for the context of the millennial generation, Ivan Illich’s progressive education will be very useful in supporting an active, creative, dynamic, and confident attitude that will be balanced if it is complemented by the spiritual nature of religiously based education.
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Gitiri, Jennifer. „Progressive Nature of Social and Economic Rights in Kenya: a Delayed Promise?“ Constitutional Review 6, Nr. 1 (02.06.2020): 133. http://dx.doi.org/10.31078/consrev615.
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This paper evaluates the steps taken towards the progressive realization of social and economic rights (SER) in Kenya. It aims to provide a better understanding of SER and the obligations of the state under international, regional, and national law. It further elucidates the components of progressive realization. Additionally, it identifies the guiding principles of measuring progressive realization and recommendations to develop tools that would monitor progressive realization. Recognition of SER faces many challenges as they are considered as second class rights that are not equal to civil and political rights considered as first-generation rights. The most enduring challenge for SER is that it interferes with the concept of the separation of powers and the political question doctrine by enabling courts to interfere in matters considered to be under the purview of the legislative and executive branch. The paper uses a desktop review of international, regional, and national legal instruments as well as comparative evaluation of SER jurisprudence from a host of jurisdictions. The concept of progressive realization is a goal in the ICSECR, Kenya’s Constitution, and other Constitutions with the implication that SER would be implemented over a period of time. Jurisprudence from other jurisdictions is evaluated to determine the lessons learned by Kenya. The paper demonstrates that progressive realization and implementation of SER are still work in progress before they are finally anchored into mainstream human rights, just like political and civic rights. In conclusion, progressive realization of SER imports an immediate obligation by Kenya having ratified the three human right bodies (ICSECR, UNCRC, and CRPWD) pursuant to Article 2(5)(6) of the Constitution to expeditiously move towards the realization of SER. There is a further presumption that the country would refrain from retrogressive measures and instead adopt the minimum content approach in the implementation of SER.
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Kolyadenko. „INFORMAL APPROACH TO ORGANIZATION OF THE EDUCATIONAL PROCESS IN VOLYNSKIY LYCEUM“. Scientific bulletin of KRHPA, Nr. 12 (2020): 23–34. http://dx.doi.org/10.37835/2410-2075-2020-12-3.
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The sense of education-on of the main part in structure of educational process that is specified in knowledge system, skills and abilities, mastering which lays the foundation for development and the formation of student’s personality. So, pedagogic system review of the Volyn Gymnasium(Lyceum) the author begins by covering questions of purpose and content of it’s education, what significantly different from generally accepted standards. The organization of the educational process at the Lyceum was of a specific character. It was caused by the educational tasks of this institution, namely to provide its students with scientific knowledge appropriate to the level of European science development, to educate the young generation in love to their native land and respect for work. Regarding the forms of organization the educational process, it should be noted that the main form of its organization was the classroom lesson system. It should be noted that Lyceum educational programs was the attempt to connect humanitarian, natural and mathematical science. In addition the inspirational of the founders of the institution transform it in to university, aroused the desire of the teachers to create educational programs in the subjects taught at the Lyceum, close to university. So, the system of organizing the education of the Volyn Gymnasium (Lyceum) was quite holistic and had progressive ideas of the European level in the field of pedagogy. These include: - in-depth language learning at the initial stage of study (4 years); - paired teaching of subjects on the principle of affinity (Polish and Latin) and associativity (Italian language and music); - introduction into the course of study some separate subjects: history, geography, law and political economy; - the presence of a number of necessary subjects that developed students’ skills (prototypes of modern elective classes): mineralogy, bibliography, architecture, military construction; - additional riding, drawing, fencing, swimming, etc. In spare time; - various local activities of pupils under the teachers guidance; - the secular nature of teaching.
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Chicherin, Stanislav, Vladislav Mašatin, Andres Siirde und Anna Volkova. „Method for Assessing Heat Loss in A District Heating Network with A Focus on the State of Insulation and Actual Demand for Useful Energy“. Energies 13, Nr. 17 (01.09.2020): 4505. http://dx.doi.org/10.3390/en13174505.
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The goal of this paper was to evaluate heat loss and the demand of district heating (DH) in the context of the fourth generation DH concept using a data-driven approach. The heat loss profile was calculated with GIS Zulu© (software (8.0.0.7539, Politerm, LLC, St.Petersburg, Russia) using eight various states of insulation, detailed information on thermal conductivity, internal heat transfer coefficient, and geometry of the concrete trench. There is a strong correlation between the heat sold and the average annual outdoor temperatures. The outstanding episodes are extremely rare, and the difference in the overall pattern is elusive. The results of the annual heat production and annual heat loss analyses were compared using three different estimation methods. The new method was the only one that showed a positive effect after the complete modernization of thermal insulation. The actual proportion of heat loss is much higher at 16%, while the actual heat delivery is less than anticipated at 85–86% only. The trend of the normative approach is correct but cannot determine changes in network heat loss due to aging. The method focuses on the effects of the state of insulation and actual supply temperature levels. The transition to smart energy systems includes strategic and progressive energy planning, as well as new pricing rules and tariffs. Thus, the method presented is the first step in the transition towards the fourth generation DH networks.
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Escolar, Gines, Jose M. Jou, Maribel Diaz-Ricart, Marc Pino, Ful Navalon, Rosa Brugues, Anna Merino und James G. White. „Stabilization of the Mean Platelet Component (MPC), a Parameter Related to Platelet Granularity Provided by New Generation of Blood Analyzers.“ Blood 108, Nr. 11 (16.11.2006): 3919. http://dx.doi.org/10.1182/blood.v108.11.3919.3919.
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Abstract Detection of platelet activation through conventional blood analyzers appears as a promising approach for a wide population of patients subjected to elevated cardiovascular risk. The mean platelet component (MPC) parameter calculated by the new generation of blood cell analyzers (ADVIA 120 and ADVIA 2120) provides direct information on density and granularity of platelets. Recent studies suggest that this parameter could correlate with the platelet activation state and become a potential predictive parameter for acute ischemic complications or thrombotic risk. Currently, the MPC parameter is largely affected by time and storage conditions. Standard anticoagulants based on K3EDTA are known to posses a deleterious effects on platelet morphology and granule content. It would be desirable that the stability of the MPC in blood specimens should be improved, to facilitate a more standardized use in different laboratories. Blood from healthy controls was collected into K3EDTA plus fixatives, additives, and stored at different conditions that could prolong the stability of the MPC. MPC and the mean platelet volume (MPV) were assessed 30 min and at 1, 3, 6 and 24 hours after blood drawing on the ADVIA 2120 system. Flow cytometry techniques were used to identify platelet-activation proteins. Impact of these strategies on ultrastructural morphology of platelets was morphometrically evaluated using electron microscopy (EM). Strategies based on addition of low concentrations of fixatives (paraformaldehyde or glutaraldehyde) that have proved useful for flow cytometry were unsuccessful to guarantee the stability of MPC. A solution based on K3EDTA containing wortmanin and tyrphostin (ED-WORTY) provided good stability for most of the parameters tested up to 6 hours at room temperature. Ultrastructural morphometry revealed a progressive statistically significant reduction in the number of alpha-granules per platelet section in samples stored in EDTA (from 12.3±6.07 to 6.4±2.3 and to 3.5±1.4; baseline, 6 and 24 h respectively, p<0.001). ED-WORTY prevented the degranulation observed in samples stored in EDTA with numbers of alpha-granules per platelet varying from 12.5±4.3 to 10.7±3.5 and to 10.9±4.7 at baseline, 6 and 24 h respectively. Storage at lower temperatures seemed to produce more favorable results, for all parameters measured, though they resulted in an enhancement of platelets positive for P-selectin. ED-WORTY solutions preserved adequate morphology and had minimal influence on other current parameters provided by the ADVIA 120/2120 Systems. Storage in current anticoagulants based on EDTA result in a progressive increase in MPV, a decrease in MPC, with a significant reduction in the number of platelet alpha-granules as revealed by EM. Addition of inhibitors of protein phosphorylation provide stability for the MPV and for the MPC parameters, and significantly prevented the degranulation caused by EDTA. These additives could be useful to guarantee the stability of MPC for prolonged periods and to facilitate the transport and exchange of samples among institutions and laboratories.
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Lawanda, Ike Iswary. „The importance of information access of cultural values to the principles of sustainable development in climate change“. Global Knowledge, Memory and Communication 69, Nr. 1/2 (22.11.2019): 9–19. http://dx.doi.org/10.1108/gkmc-03-2019-0044.
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Purpose This is a methodological proposal that describes the access to information as a starting point, and the importance of access to information as the backbone for the values of investment with the notion of culture as shared beliefs, supported by information to communicate and provide awareness about issues related to environmental policy that is consistent with sustainable development. Data collection is done from census data of Cikarawang population, observation and in-depth interviews with informants of community leaders. Constructive theory constructs to identify the diversity of existing construction of and placing in the consensus. The goal of this methodology is to produce an informed and knowledgeable construction of, which simultaneously improving continuously. Constructivists do not intend to predict and control the real world and divert it but to reconstruct the world at the point of its existence: in the mind of the people of the community in Cikarawang village. The view of the importance of cultural institutions and traditional knowledge should not be ignored in reaching the target of practical dissemination of information regarding environmental policy should be conducted for further study the model of and the model for the construction of the constructed. The use of application in documenting myths and rituals of Cikarawang people is enabling the access of information of the people in learning the culture and language of Cikarawang. Moreover, it is the way to reach the goal of sustainable environment for the next generations. Design/methodology/approach The goal of this methodology is to produce an informed and knowledgeable construction of, which simultaneously improved continuously. Constructivists do not intend to predict and control the real world and divert it but to reconstruct the world at the point of its existence: in the mind of the constructor. In the process related to two aspects, : hermeneutic and dialectical. Aspects of individual construction of hermeneutic describe as compare and contrast to the dialectical aspects of individual construction of, so that each respondent was entered into the construction of another and entirely fused. Findings The access of information on asri to face global warming is to demonstrate the hybridity and syncretism of this everyday locality and to show how this global sense of place is a progressive sense of place which avoids defensive and exclusionary definitions of place and culture because they cannot be sustained in a world where understanding a place means understanding its connection to other places. However, the youths of Cikarawang are likely to self-identify, as liberals are also more supportive of progressive domestic social agenda than older generations. They are less overtly religious than the older generations. Research limitations/implications The access of information, is about trying to establish the existence of the collectivity by defining what makes it a community – isolating national characteristics, defining crucial historical moments or significant places. None of these implies that these meanings can be fixed. There might be useful to think of nations as projects which are never fully achieved. There are always alternative accounts which are being given, and alternative interpretations being made from different positions. Climate information needs to be made in accordance with the local context and activities of both of the content, format, timing and distribution (dissemination). Practical implications The undetermined that perceived lack of locals trying to understand the information about weather and climate change are delivered by using technology need to engage their participation to identify and develop adaptation and mitigation strategies. Knowledge about the weather and how to overcome it is also myths about the environment containing taboo and prohibition as well as the annual harvest ritual. Digital technology using application is the nearest object to individual youngsters to access information openly and individually. Access of information using apps and internet is bridging the issues of climate change, myths and rituals about environment, and generation gaps. Social implications The behavior of young people of Generation X are not heeding the ban in the experience of their ancestors. It is not only because of their belief in myth depleted but also in the absence of respected elders. Person figures which are respected as wise men or local leaders to be role models. In the past, knowledge and cultural information are presented, preserved, generated down to future generations. Nowadays, information about climate, weather, cultural knowledge in agriculture, irrigation, daily life, ritual, myth, and kinship is no longer simply rely on figures but the media that they believe in. Originality/value It is an interdisciplinary research of global knowledge, memory and communication. Digital technology-based application as the system to support access of information and the effort of documentation on community myths and rituals of remote people may affect on sustainable local wisdoms which protect and sustain the environment to be inherited to next generations. Web, private social networks, wikis and blogs are becoming important corporate tools for communication, collaboration and information-sharing. It is a way of young people in this Generation X most familiar in such as interactive, collaborative, managing knowledge, and managing global system and bridging generation gaps.
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Sherstobitova, I. А. „Concept analysis on literature lessons: the text emotiogenicity of the prose poem "To the Memory of U. P. Vrevsky" by I. S. Turgenev“. Russian language at school 82, Nr. 4 (20.07.2021): 7–20. http://dx.doi.org/10.30515/0131-6141-2021-82-4-7-20.
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The paper considers the St. Petersburg concept of emotional intelligence development as a promising approach to implementing linguoconceptology in education. The aim of the study was to test a concept analysis model built on the technology of mastering the key concepts of Russian culture and the theory of multiple intelligencies proposed by Howard Gardner. The three scientific approaches – emotional intelligence theory (D. Goleman), linguoconceptocentric theory (N. L. Mishatina) and classical hermeneutics (F. Schleiermacher) constitute the methodological framework of the research. From the standpoint of hermeneutics, investigating how learners understand and interpret the emotional concept ‘the images of the lyrical hero and the heroine’ in the prose poem "To the Memory of U. P. Vrevsky" by I. S. Turgenev highlights their progression from the formation of one emotional competence to another and finally to building and developing emotional intelligence. In the course of the hermeneutical study the lyrical hero’s image is considered from the viewpoint of the emotional linguistic persona; the text of the poem is discussed as an emotiogenic text. Within the framework of laboratories-studies a system of tasks was developed to form and develop learners’ emotional intelligence. The metaphors created by the teacher and the students as well as the text of a concept-centric essay comprise the results of doing the abovementioned tasks during laboratories-studies. Our data provide evidence that conceptual analysis enables learners to decode the emotional content of the author’s values and implications. The development model of emotional intelligence based on hermeneutical conceptual analysis provides an opportunity to internalize and reinterpret iconic cultural texts, bridge the cultural generation gap and put Generation Z into the context of world history.
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Rehman, Sharaf. „Management and communication practices in Singapore: lessons from a model economy“. UR Journal of Humanities and Social Sciences 17, Nr. 4 (2020): 165–83. http://dx.doi.org/10.15584/johass.2020.4.10.
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With its 5.8 million inhabitants, retaining its unique version of democracy, and remaining a traditional yet progressive city, Singapore stands as a model economy for other Asian and middle eastern economies. From 1819 to 1963, Malaysia and Singapore – as one country – were a British colony. In 1963, when British rule ended and Malaysia gained her independence, Singapore remained a part of Malaysia. However, the racial tension between Malay, the ethnic Chinese, and other non-Malay groups escalated and turned violent. In 1965, Singapore cut her ties with Malaysia and became a sovereign, independent state. While retaining its collectivistic culture, Singapore has gained a competitive edge as a high-end shopping centre in the region. During the past 60 years, the Singaporean economy and businesses have shifted their focus from the manufacturing of electronic components, computer hard drives, small appliances, and garments to financial services, banking, insurance services, and asset management. Relying on data collected through interviews, observations, and a brief questionnaire, this case study of Singaporean businesses presents a description of the management styles and communication strategies of 78 business managers in Singapore, representing the service, retail, and manufacturing sectors. The data reveal that Human Resources Approach to management is the most common style of management. Analysis of communication content, style, and flow demonstrates that cultural customs such as respect for the elderly, caring for and mentoring the younger generation, loyalty to one’s family, and conformity to family traditions are the driving forces of the businesses in Singapore. The analysis suggests that it is the dominant culture of a society that shapes the business practices and business values in any given society.
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Paracha, Samiullah, Lynne Hall, Kathy Clawson, Nicole Mitsche und Fatima Jamil. „Co-design with Children: Using Participatory Design for Design Thinking and Social and Emotional Learning“. Open Education Studies 1, Nr. 1 (31.12.2019): 267–80. http://dx.doi.org/10.1515/edu-2019-0021.
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AbstractThis paper discusses leveraging design thinking techniques for involving children in serious game design in Japanese elementary schools. Our action research project approach accomplished two different goals: (1) to inculcate design thinking in pupils, and (2) to sensitize children on bullying victimization. Our approach uses a range of participatory design methods to distil design ideas from children and to support their design thinking aiming to boost children’s creative confidence and develop social and emotional skills. Key findings from our project are: (1) children made valuable design contributions including realistic bullying scenarios, language content, user interface design, storyline progression, character profiles, coping strategies etc., and (2) participatory design and design thinking stimulated ethical reasoning, reflection and empathy in children on bullying victimization. Our approach is unique in the current design thinking landscape, because it moves from designing “thing” (object) to designing “think” (bullying sensitization). Future research should focus on highlighting ways how participatory design and design thinking enrich and complement each other. The significance of our paper stems from the simple standpoint that those participating in a design should gain from participating in the design process. Takeaways for practitioners are: (1) building relationships with stakeholders, especially children, (2) empathy and user research techniques, (2) translating field data into usable insights, (3) idea-generation and rapid concept development, (4) product co-prototyping, (5) user engagement and co-creation, (6) multiple perspectives on effective communication.
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Ejaz, Hafza Wajeeha, Wei Wang und Minglin Lang. „Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches“. International Journal of Molecular Sciences 21, Nr. 20 (16.10.2020): 7660. http://dx.doi.org/10.3390/ijms21207660.
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Alzheimer’s disease (AD) is an irreversible, age-related progressive neurological disorder, and the most common type of dementia in aged people. Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Aβ), loaded with metal ions including Cu, Fe, or Zn. Some reports have identified metal dyshomeostasis as a neurotoxic factor of AD, among which Cu ions seem to be a central cationic metal in the formation of plaque and soluble oligomers, and have an essential role in the AD pathology. Cu-Aβ complex catalyzes the generation of reactive oxygen species (ROS) and results in oxidative damage. Several studies have indicated that oxidative stress plays a crucial role in the pathogenesis of AD. The connection of copper levels in AD is still ambiguous, as some researches indicate a Cu deficiency, while others show its higher content in AD, and therefore there is a need to increase and decrease its levels in animal models, respectively, to study which one is the cause. For more than twenty years, many in vitro studies have been devoted to identifying metals’ roles in Aβ accumulation, oxidative damage, and neurotoxicity. Towards the end, a short review of the modern therapeutic approach in chelation therapy, with the main focus on Cu ions, is discussed. Despite the lack of strong proofs of clinical advantage so far, the conjecture that using a therapeutic metal chelator is an effective strategy for AD remains popular. However, some recent reports of genetic-regulating copper transporters in AD models have shed light on treating this refractory disease. This review aims to succinctly present a better understanding of Cu ions’ current status in several AD features, and some conflicting reports are present herein.
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Moro, Francesca R. „Aspectual distinctions in Dutch-Ambon Malay bilingual heritage speakers“. International Journal of Bilingualism 21, Nr. 2 (27.07.2016): 178–93. http://dx.doi.org/10.1177/1367006915608515.
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Aims and Objectives/Purpose/Research Questions: This paper investigates the effects of Dutch on the tense-aspect system of heritage Ambon Malay, a variety spoken by Dutch-Ambon Malay bilinguals in the Netherlands. The study asks whether the cross-linguistic contrasts between the two languages – Dutch obligatorily marks past/non-past and finiteness, whereas Ambon Malay lacks a grammaticalized expression of these distinctions – has an effect on the aspectual system of heritage Ambon Malay. Design/Methodology/Approach: The database for the study consists of video descriptions provided by 32 bilingual speakers (the experimental groups) and by three control groups: 27 homeland speakers of Ambon Malay, 5 first generation speakers of Ambon Malay in the Netherlands (late bilinguals), and 10 monolingual speakers of Dutch. Data and Analysis: The frequency and distribution of aspect markers is analysed statistically in the four groups. Findings/Conclusions: The analysis of the data reveals that, under the influence of Dutch, the Ambon Malay progressive marker ada has undergone a shift in temporal status and frequency and it is now interpreted as a marker of present tense, as well as of progressive aspect. The other two aspect markers, the iamitive/perfective su and verbal reduplication (iterative) are used significantly less by heritage speakers. Originality: This study shows that when a grammatical category is present and productive in the dominant language of a bilingual heritage speaker, but not in the heritage language, there is a great likelihood that it will undergo contact-induced grammaticalization, even in a relatively short time contact situation. The study also shows that input-related factors, such as transparency and phonological salience, contribute to the (in)stability of aspectual forms in the heritage language. Significance/Implications: This finding has implication for the incomplete acquisition perspective on heritage languages, which sees these languages as grammatically simplified systems (see, e.g., Montrul, 2009; Polinsky, 2008), because it shows that heritage languages can also gain grammatical distinctions previously absent in the (homeland) language.
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Venâncio, Marina Demaria, und Kamila Pope. „Solid Waste Management and the Practice Open Dumping in Brazil: Lessons Learnt from the State of Santa Catarina“. Journal of Vasyl Stefanyk Precarpathian National University 5, Nr. 2 (23.08.2018): 178–89. http://dx.doi.org/10.15330/jpnu.5.2.178-189.
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In the context of several complex global issues that challenge modern societies, the large-scale generation of solid waste and its inadequate disposal are rather intricate problems that threaten not only human livelihoods but also the life on the planet. More specifically, the practice of open dumping, which concerns to the illegal use of irregular sites for waste disposal, characterized by the absence of adequate environmental and health standards, is considered a global health an environmental emergency, demanding urgent action from Governments and individuals. Given that, this paper aims at providing a brief overview of the solid waste management scenario in Brazil, giving emphasis to the issue of open dumping and the challenges in tackling this problem. More specifically, it seeks to analyze the case of the State of Santa Catarina as a success story of deactivation of irregular dumpsites. The paper is therefore divided into three main sections. The first contextualizes the issue of solid waste and open dumping in Brazil. The second, explores the Brazilian framework for solid waste management, especially the National Policy for Solid Waste. Finally, the third discusses the successful case of Santa Catarina. All in all, it was possible to conclude that the Brazilian legislation on waste management is very progressive and address the issue with a systemic approach, which is one of the essential elements to achieve a sound waste management. Reforming the Brazilian infrastructure to better manage the waste produced, closing all open dumpsites and building proper landfills, are other crucial elements in transforming the country’s system, being the case of Santa Catarina an empirical proof of the fundamentality of the adoption of a systemic approach.
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Boreham, C. J., J. M. Hope und B. Hartung-Kagi. „UNDERSTANDING SOURCE, DISTRIBUTION AND PRESERVATION OF AUSTRALIAN NATURAL GAS: A GEOCHEMICAL PERSPECTIVE“. APPEA Journal 41, Nr. 1 (2001): 523. http://dx.doi.org/10.1071/aj00026.
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Natural gases from all of Australia’s major gas provinces in the Adavale, Amadeus, Bass, Bonaparte, Bowen/ Surat, Browse, Canning, Carnarvon, Cooper/Eromanga, Duntroon, Gippsland, Otway and Perth basins have been examined using molecular and carbon isotopic compositions in order to define their source, maturity and secondary alteration processes.The molecular compositions of the gaseous hydrocarbons range from highly wet to extremely dry. On average, reservoired gases predominantly derived from land plants are slightly wetter than those derived from marine sources. The non-hydrocarbon gases CO2 and N2 were sourced from both inorganic and organic materials. A mantle and/or igneous origin is likely in the majority of gases with CO2 contents >5%. For gases with lower CO2 contents, an additional organic input, associated with hydrocarbon generation, is recognised where δ13C CO2 is A strong inter-dependency between source and maturity has been recognised from the carbon isotopic composition of individual gaseous hydrocarbons. This relationship has highlighted some shortcomings of common graphical tools for interpretation of carbon isotopic data. The combination of the carbon isotopic composition of gaseous hydrocarbons and the low molecular weight nalkanes in the accompanying oil allows our knowledge of oil-source correlations and oil families to be used to correlate gases with their sources. This approach has identified source rocks for gas ranging in age from the Ordovician in the Amadeus Basin to Late Cretaceous- Early Tertiary sources in the Bass and Gippsland basins. The carbon isotopic composition of organic matter, approximated using the δ13C of iso-butane, shows a progressive enrichment in 13C with decreasing source age, together with marine source rocks for gas being isotopically lighter than those from land plant sources. The Permian was a time when organic matter was enriched in 13C and isotopically uniform on a regional scale.Secondary, in-reservoir alteration has played a major role in the modification of Australian gas accumulations. Thus, biodegradation, prominent in the Bowen/Surat, Browse, Carnarvon and Gippsland basins, is found in both hydrocarbon and non-hydrocarbon gases. This is recognised by an increase in gas dryness, elevated isoalkane to n-alkane ratio, differential increase in δ13C of the individual wet gas components, a decrease in δ13C of methane and a reduction in CO2 content concomitant with enrichment in 13C. Evidence of water-washing has been identified in accumulations in the Bonaparte and Cooper/Eromanga basins, resulting in an increase in the wet gas content. Seal integrity is also a major risk for the preservation of natural gas accumulations, although its effect on gas composition is only evident in extreme cases, such as the Amadeus Basin, where preferential leakage of methane in the Palm Valley field has resulted in the residual methane becoming enriched in 13C.The greater mobility of gas within subsurface rocks can have a detrimental effect on oil composition whereby gas-stripping of light hydrocarbons is common amongst Australian oil accumulations. Alternatively, the availability of gas, derived from a source rock common to or different from oil, was likely to have been a prime factor controlling the regional distribution of oil, whereby mixing of both results in increased oil mobility and can lead to a greater access to the number and types of traps in the subsurface.
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Cohen, Michael F., Shenchang Eric Chen, John R. Wallace und Donald P. Greenberg. „A progressive refinement approach to fast radiosity image generation“. ACM SIGGRAPH Computer Graphics 22, Nr. 4 (August 1988): 75–84. http://dx.doi.org/10.1145/378456.378487.
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Zhu, Jin, Yoshiyori Urano, Hidenori Nakazato und Qun Jin. „A progressive approach for cross-browser web data generation“. International Journal of Computational Science and Engineering 9, Nr. 3 (2014): 235. http://dx.doi.org/10.1504/ijcse.2014.060674.
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Astashova, N. A., S. K. Bondyreva und A. P. Smantser. „DEVELOPMENT OF THE AXIOSPHERE OF THE FUTURE TEACHER IN THE DIALOGUE SPACE OF MODERN EDUCATION“. Education and science journal 20, Nr. 7 (17.09.2018): 32–67. http://dx.doi.org/10.17853/1994-5639-2018-7-32-67.
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Introduction. The vector of development of the education system, the choice of its contents, quality and results of training, style and spirit of the relationship of its participants, degree of their informative activity, intellectual and cultural growth are firstly caused by valuable attitudes of participants of the educational process. A teacher is a bearer of values. One of the main functions of the teacher is the education of the younger generation, the introduction of the person to moral ethics and universal values. In this regard, training of future teachers has to include the purposeful formation of the system of the internal, emotionally experienced values which will help them to cope with the complex of socio-cultural problems in the future professional activity.The aim of the paper is to present the research findings on the conceptual model of the dialogue space of education as the basis for the development of the future teacher axiosphere which corresponds to current ideological, social, economic, technological and other progressive civilization trends.Methodology and research methods. In the course of the research, fundamental ideas of the following scientific approaches were applied: humanistic approach – free and creative development of an individual; dialogical approach – pluralism of opinions and a variety of positions of subjects of education; axiological approach – attitude of the individual to the world around him/her, to other people and to himself / herself; activity approach – specific activity of the individual, aimed at appropriation of social experience by the person, change of the surrounding world and selfhood. To design and organize the model of the dialogue space, the methods of analysis, synthesis and generalization of the theory and practice were used.Results and scientific novelty. The authors presented the strategic guidelines of the interactive environment education: the development of social cooperation, using the pedagogical peaceful potential, the development of interpersonal and intergroup relations, organizing children spiritual and moral education as a national priority. The teacher value system was revealed empirically and described. It was found out that a modern teacher should responsibly perform the professional duties of a mentor, tutor and facilitator of the educational process. The authors clarified the concept of “axiological sphere” of the teacher. The teacher axiological sphere is considered as a complex of personal, professional-pedagogical and socio-cultural values. These values have separable functions. Firstly, they determine the content and nature of the educational activity. Secondly, they regulate the interaction of the participants of the educational activity. Thirdly, they stimulate personal self-expression of the members of that activity. Fourthly, they directly influence the efficiency and effectiveness of education.The conceptual model of dialogue space of education as a formation zone for the teacher’s axiosphere was designed on the basis of the theoretic-methodological, philosophical, psychological and pedagogical concepts of the leading scholars’ writings. The resources of this space were identified; its structural components were presented and proved. The implementation of the components mentioned above can create a special context for the humanitarian training of a future teacher; will give an opportunity of interactive development of students’ common cultural, communicative and special competencies; will increase students’ motivation to pedagogical activity, the search of new ideas for training, innovations and professional self-education. The authors demonstrated the value orientations typology and tactics of their acquisition by students at the dialogue level.Practical significance. The presented materials can be used in practice of the higher pedagogical education to improve the quality of graduates’ training through enrichment of their personality axiological sphere. The model for the formation of the future teachers’ value system in dialogue educational space will allow providing conditions for individualization of routes of their training taking into account different approaches to the organization of activity of education participants and features of their self-development.
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Wolffram, Dirk Jan. „De BMGN als platform voor vernieuwing van de politieke geschiedenis“. BMGN - Low Countries Historical Review 136, Nr. 2 (05.07.2021): 136–49. http://dx.doi.org/10.51769/bmgn-lchr.9887.
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De politieke geschiedenis van Nederland en België zoals bestudeerd in de BMGN had verschillende gezichten. Aanvankelijk domineerde een zekere traditionele geschiedschrijving over beide landen, die als een steeds dunner wordende rode draad door de inhoud van de afgelopen vijftig jaar loopt. Vanaf het midden van de jaren tachtig verschoof de nadruk naar de geschiedschrijving over de Nederlandse politiek, en ontwikkelde de BMGN zich tot platform voor de vernieuwing van de politieke geschiedenis van de moderne tijd. Deze politieke-cultuurbenadering manifesteerde zich vanaf het midden van de jaren negentig in een aantal baanbrekende artikelen en bracht ook de moderne Belgische politieke geschiedenis opnieuw onder de aandacht. In het afgelopen decennium ontpopte de BMGN zich tot podium voor een jonge generatie politieke historici. Studies of the political history of the Netherlands and Belgium as examined in the BMGN had various manifestations. Initially a somewhat traditional historiography about the two countries dominated, surfacing in the content of the past fifty years, albeit progressively less pronounced. From the mid 1980s the focus shifted to the historiography of Dutch politics, and the BMGN evolved into a platform for innovating political history writing of the modern period. This political-cultural approach manifested from the mid 1990s in several pioneering articles and restored interest in modern Belgian political history. In the past decade the BMGN has become a platform for a young generation of political historians.
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Barna, Stepan. „INNOVATIVE ACTIVITY IN THE MANAGEMENT SYSTEM OF ENERGY SERVICE ENTERPRISES“. Economic discourse, Nr. 4 (Dezember 2019): 79–86. http://dx.doi.org/10.36742/2410-0919-2019-4-8.
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Introduction. The phenomenon of innovations and innovative system reflects the dynamics of society, covers all spheres of life, and carries a benchmark for the future. The essence of this phenomenon requires thorough research from the standpoint of philosophical, scientific, technical, economic and socio-cultural aspects. Based on the growing powerful legal framework, the leading role of innovation activity for the state as a whole and for individual enterprises emerges, and the need for enhancing innovation activity, enhancing innovation potential and systematic targeted planning, development, implementation and use of innovations is evident. Methods. The method of comparison was used to identify differences between the innovation processes of developed and developing countries; generalization - to define the general concept and understanding of the principles of functioning of the subjects of the innovation process; abstraction - to identify the most relevant links for innovative business development. Results. The study suggests that the solution to the problems of forming an effective enterprise management innovation system that meets the goals of their innovation strategy depends on the use of progressive methods and approaches, adequate elements of models of innovation processes of modern generations, as well as meets the conditions of informatization and digitization of the economy. Discussion. Scientists are faced with the need to develop a number of provisions that broaden the understanding of the development of enterprise innovation management system, concentrating the need to increase innovation activity, increase innovation potential and carry out systematic targeted planning, development, implementation and use of innovation; substantiation of the feasibility of applying a systematic approach to innovation management; formation of the content and structure of the model of enterprise innovation management system. Keywords: European standards, innovations, management, energy service enterprises.
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Lambiri, Dionysia, Alessandra Faggian und Neil Wrigley. „Linked-trip effects of ‘town-centre-first' era foodstore development: An assessment using difference-in-differences“. Environment and Planning B: Urban Analytics and City Science 44, Nr. 1 (27.07.2016): 160–79. http://dx.doi.org/10.1177/0265813515624684.
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High levels of out-of-centre foodstore developments in the 1980s and early 1990s significantly altered the commercial landscape of the UK, and were widely seen as threatening the vitality and viability of small and medium-sized centres. The progressive tightening of retail planning regulation in the decade that followed, and retailer adaptation to that tightening, resulted in the development of more flexible foodstore formats suited to in-centre or edge-of-centre sites, which worked ‘with the grain’ of the ‘town centre first’ approach to retail planning policy. Since then academic research has started to suggest a more positive role for such developments than hitherto, and to indicate that they can play an important role in anchoring small centres. The key mechanism underlining this potential positive role is that of linked trips, whereby the spatial externality generated by a foodstore development is transmitted to the existing retail structure of the centre in which development has occurred. Even though UK planning policy has consistently viewed the role of linked shopping trips as critical to town centre vitality, available evidence on this key issue remains remarkably scarce and dated in terms of the planning regulation context from which it was generated. This paper aims to fill that gap. We make use of a large and unique database on consumer shopping behaviour collected over the period August 2007–November 2009 in selected UK centres, and employ the difference-in-differences method to obtain insight into the hypothesised uplift in linked trip propensity which can be attributed to a foodstore development. Our results indicate that the development of new-generation foodstores in in-centre and edge-of-centre locations does indeed increase the propensity of shoppers to link their trips between foodstores and town centre shops/services. Controlling for shoppers’ individual characteristics, that increase is shown to be over seven percentage points. The exact numerical value is likely to be sample specific, and its typical range will only be established by replication. However, the importance of the finding is that using sophisticated but appropriate statistical methodology and a large sample of data from a transparently designed and rigorously conducted study, the development of ‘new-generation’ town-centre first foodstores is clearly associated with increased linked trip propensities. To our knowledge, this is the first time unambiguous evidence of the existence of this hypothesised ‘town centre first era’ linked-trip effect has been demonstrated.
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Steinbaum, Marshall I., und Bernard A. Weisberger. „The Intellectual Legacy of Progressive Economics: A Review Essay of Thomas C. Leonard's Illiberal Reformers“. Journal of Economic Literature 55, Nr. 3 (01.09.2017): 1064–83. http://dx.doi.org/10.1257/jel.20171436.
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Thomas Leonard's 2016 book Illiberal Reformers: Race, Eugenics, and American Economics in the Progressive Era argues that exclusionary views on eugenics, race, immigration, and gender taint the intellectual legacy of progressive economics and economists. This review essay reconsiders that legacy and places it in the context within which it developed. While the early generations of scholars who founded the economics profession in the United States and trained in its departments did indeed hold and express retrograde views on those subjects, those views were common to a broad swath of the intellectual elite of that era, including the progressives' staunchest opponents inside and outside academia. Moreover, Leonard anachronistically intermingles a contemporary critique of early-twentieth-century progressive economics and the progressive movement writ large, serving to decontextualize those disputes—a flaw that is amplified by the book's unsystematic approach to reconstructing the views and writing it attacks. Notwithstanding the history Leonard presents, economists working now nonetheless owe their progressive forebears for contributions that have become newly relevant: the “credibility revolution,” the influence of economic research on policy and program design, the prestige of economists working in and providing advice to government agencies and policy makers, and the academic freedom economists enjoy in modern research-oriented universities are all a part of that legacy. (JEL A11, B15, D82, J15, N31, N32)
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Bibichkov, Igor, Vadym Sokol und Oleksandr Shevchenko. „Ontological approach to development of web-content generation method“. Technology audit and production reserves 5, Nr. 2(49) (31.10.2019): 4–10. http://dx.doi.org/10.15587/2312-8372.2019.183201.
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Yongyi Yang, M. N. Wernick und J. G. Brankov. „A fast approach for accurate content-adaptive mesh generation“. IEEE Transactions on Image Processing 12, Nr. 8 (August 2003): 866–81. http://dx.doi.org/10.1109/tip.2003.812757.
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Rubegni, Anna, Alessandro Malandrini, Claudia Dosi, Guja Astrea, Jacopo Baldacci, Carla Battisti, Giulia Bertocci et al. „Next-generation sequencing approach to hyperCKemia“. Neurology Genetics 5, Nr. 5 (16.08.2019): e352. http://dx.doi.org/10.1212/nxg.0000000000000352.
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ObjectiveNext-generation sequencing (NGS) was applied in molecularly undiagnosed asymptomatic or paucisymptomatic hyperCKemia to investigate whether this technique might allow detection of the genetic basis of the condition.MethodsSixty-six patients with undiagnosed asymptomatic or paucisymptomatic hyperCKemia, referred to tertiary neuromuscular centers over an approximately 2-year period, were analyzed using a customized, targeted sequencing panel able to investigate the coding exons and flanking intronic regions of 78 genes associated with limb-girdle muscular dystrophies, rhabdomyolysis, and metabolic and distal myopathies.ResultsA molecular diagnosis was reached in 33 cases, corresponding to a positive diagnostic yield of 50%. Variants of unknown significance were found in 17 patients (26%), whereas 16 cases (24%) remained molecularly undefined. The major features of the diagnosed cases were mild proximal muscle weakness (found in 27%) and myalgia (in 24%). Fourteen patients with a molecular diagnosis and mild myopathic features on muscle biopsy remained asymptomatic at a 24-month follow-up.ConclusionsThis study of patients with undiagnosed hyperCKemia, highlighting the advantages of NGS used as a first-tier diagnostic approach in genetically heterogeneous conditions, illustrates the ongoing evolution of molecular diagnosis in the field of clinical neurology. Isolated hyperCKemia can be the sole feature alerting to a progressive muscular disorder requiring careful surveillance.
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Low, Jonathan, Michele Dowless, Tatiyana Shiyanova, Scott Rowlinson, Lucia Ricci-Vitiani, Ruggero de Maria, Roberto Pallini und Louis Stancato. „Knockdown of Cancer Testis Antigens Modulates Neural Stem Cell Marker Expression in Glioblastoma Tumor Stem Cells“. Journal of Biomolecular Screening 15, Nr. 7 (16.07.2010): 830–39. http://dx.doi.org/10.1177/1087057110374983.
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The cancer stem cell hypothesis posits that a subpopulation of cancer stem cells is frequently responsible for a tumor’s progression and resistance to treatment. The differential cellular morphology and gene expression between cancer stem cells and the majority of the tumor is becoming a point of attack for research into the next generation of therapeutic agents that may work through an induction of differentiation rather than apoptosis. Advances in the field of high-content imaging (HCI), combined with modern shRNA technology and subpopulation analysis tools, have created an ideal screening system to detect these morphological changes in a subset of cells upon gene knockdown. The authors examined several glioblastoma stem cell isolates pre- and postdifferentiation to elucidate the phenotypic effects caused by both serum differentiation and gene knockdown. Neural markers were first characterized in these cells at varying states of differentiation using HCI and immunoblots. The authors then chose one of these isolates, in both the pre- and postdifferentiated forms, for further analysis and screened for morphological changes upon shRNA knockdown of a panel of cancer testis antigens (CTAs). CTAs are a family of proteins that are normally expressed in male germ cells as well as heterogeneously expressed in some metastatic tumors. This gene family has also been implicated in the differentiation of normal human stem cells, therefore making it an ideal candidate for modulation in tumor stem cells. Using their approach, the authors identified the differential effects of gene knockdown in both cell types leading to either changes in neural stem cell marker expression or a decreased cell density likely due to growth arrest or cell death. The resolution that HCI brings to a screen at the subpopulation level makes it an excellent tool for the analysis of phenotypic changes induced by shRNA knockdown in a variety of tumor stem cells.
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Hooshyar, D., M. Yousefi, M. Wang und H. Lim. „A data-driven procedural-content-generation approach for educational games“. Journal of Computer Assisted Learning 34, Nr. 6 (07.06.2018): 731–39. http://dx.doi.org/10.1111/jcal.12280.
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Biondi, Andrea, und Giovanni Cazzaniga. „Genetics Directing Therapy in Acute Lymphocytic Leukemia: Identifying Risk, Defining Targets“. Blood 126, Nr. 23 (03.12.2015): SCI—35—SCI—35. http://dx.doi.org/10.1182/blood.v126.23.sci-35.sci-35.
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In contemporary clinical trials, the 5-year survival rate in pediatric ALL, has risen above 85% in developed countries. This achievement is due at least in part to better defined patient risk classification, optimization of antileukemic agents, and improved supportive care. In order to refine the approach to define the risk of patients and to cope with these challenges, the use of MRD tests has become prominent in ALL management. The main reasons for this development have been the progressive improvement of standardized methodologies applicable to virtually all patients and the conduct of clinical studies that used MRD evaluation as a marker of in vivo early response to allocate patients into different risk-based treatments to improve outcome. This hold true for BCP-ALL as well for T-ALL. This is the context where over the past decade, genome sequence and adequate analytical platforms, such as gene expression profiling, single nucleotide polymorphism arrays, and, more recently, next generation sequencing, has expanded our knowledge and definition of new molecular ALL entities. These achievements have also provided critical insights regarding potentially targetable lesions for development of new therapeutic approaches in the era of precision medicine. The current genetic landscape of childhood ALL with emphasis upon patient outcomes with contemporary treatment regimens will be reviewed. While the assessment of new genetic lesions as potential new risk factors are currently evaluated in the MRD-based clinical ALL studies, defining targets for new therapeutic intervention is still very challenging. In vitro and in vivo evaluation of new agents in ALL model systems remains a lengthy and often imperfect system. Single-agent biologic activity in murine models does not always translate into clinical activity in patients, and improper drug schedule can result in untoward clinical outcomes. Moreover, for the emerging knowledge on the clonal evolution in cancer in general and in leukemia as well it is evident that leukemia evolves by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscape of tissue ecosystem. The dynamics is complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy leukemia clones but it can provide also a potent pressure for the expansion of resistant variants. This Darwinian character of leukemia can be the primary reason for therapeutic failure but it may hold the key for a more effective control. In this increasingly smaller subsets of patients, clinical trial design for evaluation of new agents also represents a new challenge, and development of robust biomarkers of response will be necessary to define clinical activity. The trend to reduce subgroups further sustain the need for continuous collaboration among researchers, clinical oncologists, government agencies, and pharmaceutical industries. Finally, the progressive and functional definition of genetic entities that can benefit of tailored treatment will have relevant implications for clinical studies. Disclosures No relevant conflicts of interest to declare.
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Svіtlenko, Serhii. „Ukrainian intellectual Alexander Rusov. Part 1. Appearance in the world of the Ukrainian national elite“. Grani 23, Nr. 4 (05.07.2020): 93–107. http://dx.doi.org/10.15421/172044.
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The article aims to study the formation and affirmation of A.A. Rusov`s personality as a Ukrainian intellectual and his appearance in the world of the Ukrainian national elite at the post-reform period of the 1860s and 1870s. It is used a personalistic approach, historical-genetic and historical-typological methods. Using archival and published documentary sources, the author shows that A. Rusov got interested in intellectual work since his adolescence and youth. The influential factors of his outlook formation were as follows: his parents influence, gymnasium secondary education, academic and students environment at St. Vladimir Kyiv University. It was found out that while doing Slavic Studies, Alexander Alexandrovich, who was a Russian by ethnic origin, became interested in studying the Ukrainian people, their language, folklore, ethnography, culture. Due to those changes he became a conscious Ukrainian who then joined the Ukrainian national movement. It is revealed A. Rusov's participation in the various national and cultural activities of the Kyiv Old Community and its legal branch – the Southwestern Department of the Russian Geographical Society. It is traced that in the 1870's the main vectors of the intellectual interests of the scientist and public figure were determined. Firstly, they were Slavic Studies, pedagogical and scientific-pedagogical activities. Then he was fond of local and regional statistical researches, determined by his interest to the comprehensive study of the Ukrainian people in the context of so called peoplelovers` (the Narodolubtsies`) worldview. It is proved that in the late 1870's A. A. Rusov became a prominent figure of the Ukrainian national movement who participated in ideological discussions between the Ukrainian “peoplelovers”, liberals and the Russian social-revolutionary Narodniks. It is emphasized that the Ukrainian intellectual and public figure companied for the rights of the Ukrainians to speak their own language, get national education, science, develop culture, implement progressive land taxation and carry on comprehensive study about the Ukrainian people using statistical surveys. The originality and scientific novelty of the article consists in presentation of factual historical knowledge about A. A. Rusov as a Ukrainian intellectual, who joined the world of the national elite generation and combined scholarly studies and social practices of national culture in his activity.
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Ghilain, Nicolas, Alirio Arboleda, Okke Batelaan, Jonas Ardö, Isabel Trigo, Jose-Miguel Barrios und Francoise Gellens-Meulenberghs. „A New Retrieval Algorithm for Soil Moisture Index from Thermal Infrared Sensor On-Board Geostationary Satellites over Europe and Africa and Its Validation“. Remote Sensing 11, Nr. 17 (21.08.2019): 1968. http://dx.doi.org/10.3390/rs11171968.
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Monitoring soil moisture at the Earth’surface is of great importance for drought early warnings. Spaceborne remote sensing is a keystone in monitoring at continental scale, as satellites can make observations of locations which are scarcely monitored by ground-based techniques. In recent years, several soil moisture products for continental scale monitoring became available from the main space agencies around the world. Making use of sensors aboard polar satellites sampling in the microwave spectrum, soil moisture can be measured and mapped globally every few days at a spatial resolution as fine as 25 km. However, complementarity of satellite observations is a crucial issue to improve the quality of the estimations provided. In this context, measurements within the visible and infrared from geostationary satellites provide information on the surface from a totally different perspective. In this study, we design a new retrieval algorithm for daily soil moisture monitoring based only on the land surface temperature observations derived from the METEOSAT second generation geostationary satellites. Soil moisture has been retrieved from the retrieval algorithm for an eight years period over Europe and Africa at the SEVIRI sensor spatial resolution (3 km at the sub-satellite point). The results, only available for clear sky and partly cloudy conditions, are for the first time extensively evaluated against in-situ observations provided by the International Soil Moisture Network and FLUXNET at sites across Europe and Africa. The soil moisture retrievals have approximately the same accuracy as the soil moisture products derived from microwave sensors, with the most accurate estimations for semi-arid regions of Europe and Africa, and a progressive degradation of the accuracy towards northern latitudes of Europe. Although some possible improvements can be expected by a better use of other products derived from SEVIRI, the new approach developped and assessed here is a valuable alternative to microwave sensors to monitor daily soil moisture at the resolution of few kilometers over entire continents and could reveal a good complementarity to an improved monitoring system, as the algorithm can produce surface soil moisture with less than 1 day delay over clear sky and non-steady cloudy conditions (over 10% of the time).
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Kalaitzidis, Pantelis. „New trends in Greek Orthodox theology: challenges in the movement towards a genuine renewal and Christian unity“. Scottish Journal of Theology 67, Nr. 2 (03.04.2014): 127–64. http://dx.doi.org/10.1017/s0036930614000039.
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AbstractTheology in Greece today is the outcome of a long and complex historical process in which many different, and even contradictory, trends and theological proclivities have converged and continue to converge, thereby defining its shape and agenda. The present article tries to provide, in four sections, both a descriptive and critical account of this complex and fascinating history.Among these trends, a decisive role is attributed in the first section of the paper to the so-called ‘generation of the 1960s’ (including among others pre-eminent Greek theologians such as Metropolitan of Pergamon John D. Zizioulas, Christos Yannaras, Nikos Nissiotis, Fr John Romanides, Panagiotis Nellas), a Greek theological movement for renewal inspired mainly by the theology of the Russian diaspora and the call to ‘return to the Fathers’, which was instrumental in shaping contemporary Orthodox theology both in Greece and outside the Greek-speaking world.In the second section are given the reactions to and criticism of the ‘theology of 1960s’. There were strong disputes and rejection on the one hand by conservative Greek academic and ecclesiastical circles, and on the other hand from the opposite progressive side (mainly the professors of the Theology School of Thessaloniki University during the 1990s), which accused this theological movement of conservatism and anti-Westernism.The emergence of the agenda initiated by the new theological generation (of 2000) is discussed in the main and longer (third) section. This new theological agenda and its principal characteristics come from points of disagreement with the theologians of the generation of the 1960s, and from a renewed and more inclusive understanding of Orthodox theology which goes beyond the problématique, the language and the agenda of the 1960s. Among the topics raised and discussed by the new trends of Greek theology are: the rediscovery of eschatology and its dynamic interpretation, ecclesiological issues, such as the centrality of the episcopal office, and the critique of the dominant place of monasticism in the life of the church, the movement of liturgical renewal, the revalorisation of mission, the rediscovery of ethics and the dilemma of ethics versus ontology, the renewed interest in political theology, the overcoming of anti-Westernism and of the West–East divide as a central interpretative key, a more constructive relationship between Orthodoxy and modernity, the critical approach of the ‘return to the Fathers’ movement, the reconsideration of the devaluation of biblical studies, the emergence of an Orthodox feminist theology and the debate on women's ordination, the radical critique of religious nationalism, and the devolution into Byzantinism and ecclesiastical culturalism.In the fourth section the article names the settings and institutions that are hosting the new theological trends in Greek Orthodoxy, mainly mentioning the leading Greek Orthodox theological quarterly Synaxi, the official scholarly journal of the Church of Greece, Theologia, the Biblical Foundation of Artos Zoes and its Bulletin of Biblical Studies and, finally, the Volos Academy for Theological Studies. An overall group vision and esprit de corps which could integrate the individual efforts and provide an identity, clearly missing from the above-mentioned picture, are demanded from the two theological schools of Athens and Thessaloniki.The article concludes by briefly reviewing the conservative and fundamentalist reactions towards this new theological agenda, and by highlighting the urgent need for contemporary Greek theology to face the new, dynamic and particularly challenging global context, and to continue to reflect and to act towards Christian unity, as well as move to reconciliation between Christian East and West, Eastern and Western Europe.
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Smith, Adam M., und Michael Mateas. „Answer Set Programming for Procedural Content Generation: A Design Space Approach“. IEEE Transactions on Computational Intelligence and AI in Games 3, Nr. 3 (September 2011): 187–200. http://dx.doi.org/10.1109/tciaig.2011.2158545.
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Dykstra, Michelle L., James D. Foster, Kathleen A. Kleiner und Christopher J. Koch. „Integrating across the Psychology Curriculum: A Content Review Approach“. Journal of Psychology and Theology 23, Nr. 4 (Dezember 1995): 277–88. http://dx.doi.org/10.1177/009164719502300408.
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Teaching integration at the undergraduate level requires thoughtful coordination among psychology faculty. This article describes a content review process by which complimentary strengths and perspectives can be discovered and used to design a coordinated integration curriculum. The George Fox College undergraduate psychology department's integration content review is offered as an example. A content review requires a framework for both exploration of integration activity and desired outcomes. We propose four levels of integration activity in the classroom: (a) modeling of personal faith, (b) integrative discussions, (c) integration readings, and (d) course level integration. These levels are progressive, complimentary, and dependent, to some extent, on the course content. In addition, careful articulation of the knowledge, skills, and attitudes the department wishes a student to have at graduation is important for the design of an integration curriculum and for assessing outcomes. The content review is an opportunity for the department to coordinate efforts toward a multi-layered integration of psychology and Christian faith.
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Saeed, Abdullah. „Some reflections on the Contextualist approach to ethico-legal texts of the Quran“. Bulletin of the School of Oriental and African Studies 71, Nr. 2 (Juni 2008): 221–37. http://dx.doi.org/10.1017/s0041977x08000517.
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AbstractA “contextualist” reading of the Quran is becoming increasingly popular, particularly among those Muslims referred to as “progressive-ijtihadis”. One of the primary concerns of this reading is that in order to understand and interpret the ethico-legal content of the Quran and relate that content to the changing needs and circumstances of Muslims today, it is important to approach the text at different levels, giving a high degree of emphasis to the socio-historical context of the text. In the classical tafsīr this emphasis on socio-historical context was not considered important, particularly in the interpretation of the ethico-legal texts, despite the frequent use of asbāb al-nuzūl literature. In this paper, I will explore how progressive-ijtihadis are adopting a contextualist reading of ethico-legal texts of the Quran. To illustrate this, I will use one or two such texts (verses) and their interpretations by the progressive-ijtihadis and will seek to demonstrate the contours of this approach, and highlight some of the challenges this approach is facing.
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Chen, Xuewen, Jinlong Li und Haihan Wang. „Keyphrase Enhanced Diverse Beam Search: A Content-Introducing Approach to Neural Text Generation“. IEEE Access 7 (2019): 72716–25. http://dx.doi.org/10.1109/access.2019.2919974.
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Abdelkrim, Latreche, Lehireche Ahmed und Kadda Benyahia. „Interrogation Based on Semantic Annotations“. International Journal of Web Portals 9, Nr. 2 (Juli 2017): 47–67. http://dx.doi.org/10.4018/ijwp.2017070103.
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Traditional information search approaches do not explicitly capture the meaning of a keyword query, but provide a good way for the user to express his or her information needs based on the keywords. In principle, semantic search aims to produce better results than traditional keyword search, but its progression has retarded because of to the complexity of the query languages. In this article, the authors present an approach to adapt keyword queries to querying the semantic web based on semantic annotations: the approach automatically construct structured formal queries from keywords. The authors propose a new process where they introduce a novel context-based query autocompletion feature to help the users to construct their keywords query by suggesting queries given prefixes. They also address the problem of context-based generating formal queries by exploiting user's query history, where previous queries can be used as contextual information for generating a new query. With the first tests, the authors' approach achieved encouraging results.
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Xu, Yi, Roger Smeets und Rafael Bidarra. „Procedural generation of problems for elementary math education“. International Journal of Serious Games 8, Nr. 2 (04.06.2021): 49–66. http://dx.doi.org/10.17083/ijsg.v8i2.396.
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Mathematics education plays an essential role in children’s development, and there are many online applications aimed at supporting this process. However, manually creating math problems with a variety of textual and visual content is very time-consuming and expensive. This article presents a generic approach for procedural generation of mathematical problems, including their corresponding textual representations. The content generation process consists of two phases: abstract math problem generation and text generation. For the generation of abstract math problems, we propose a generic template-based method that operates across a variety of difficulty-levels and domains, including arithmetic, comparison, ordering, mathematical relationships, measurement, and geometry. Subsequently, we propose a multi-language adaptive textual content generation pipeline to realize the generated abstract math problems into semantically coherent text questions in natural language. A workflow time gain evaluation shows that the system yields an average time saving of 56%. Further, human expert evaluation of this approach indicates that the content it generates is sensible and solvable for primary school students.
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Hosseini, Roozbeh, und Ali Shourideh. „Retirement Financing: An Optimal Reform Approach“. Econometrica 87, Nr. 4 (2019): 1205–65. http://dx.doi.org/10.3982/ecta15088.
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We study Pareto optimal policy reforms aimed at overhauling retirement financing as an integral part of the tax and transfer system. Our framework for policy analysis is a heterogeneous‐agent overlapping‐generations model that performs well in matching the aggregate and distributional features of the U.S. economy. We present a test of Pareto optimality that identifies the main source of inefficiency in the status quo policies. Our test suggests that lack of asset subsidies late in life is the main source of inefficiency when annuity markets are incomplete. We solve for Pareto optimal policy reforms and show that progressive asset subsidies provide a powerful tool for Pareto optimal reforms. On the other hand, earnings tax reforms do not always yield efficiency gains. We implement our Pareto optimal policy reform in an economy that features demographic change. The reform reduces the present discounted value of net resources consumed by each generation by about 7 to 11 percent in the steady state. These gains amount to a one‐time lump‐sum transfer to the initial generation equal to 10.5 percent of GDP.
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Khlif, Naziha, Ahmed Ghorbel, Walid Aydi und Nouri Masmoudi. „Generation of Chaotic Signal for Scrambling Matrix Content“. International Arab Journal of Information Technology 17, Nr. 4 (01.07.2020): 548–53. http://dx.doi.org/10.34028/iajit/17/4/13.
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Very well evolved, information technology made so easy the transfer of all types of data over public channels. For this reason, ensuring data security is certainly a necessary requirement. Scrambling data is one solution to hide information from non authorized users. Presenting matrix content, image scrambling can be made by only adding a mask to the real content. A user, having the appropriate mask, can recognize the image content by only subtracting it. Chaotic function is recently used for image encryption. In this paper, an algorithm of image scrambling based on three logistic chaotic functions is proposed. Defined by its initial condition and parameter, each chaotic function will generate a random signal. The set of initial conditions and parameters is the encryption key. The performance of this technique is ensured for two great reasons. First, using masks on the image makes unintelligible its content. Second, using three successive encryption processes makes so difficult attacks. This point reflects, in one hand, a sufficient key length to resist to brute force attack. In the other hand, it reflects the random aspect of the pixel distribution in the scrambled image. That means, the randomness in one mask minimizes the correlations really existent between neighboring pixels. That makes our proposed approach resistant to known attacks and suitable for applications requiring secure data transfer such as medical image exchanged between doctors
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Bacher, U. „3D CONTENT GENERATION USING HYBRID AERIAL SENSOR DATA“. International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLIII-B2-2021 (28.06.2021): 297–303. http://dx.doi.org/10.5194/isprs-archives-xliii-b2-2021-297-2021.
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Abstract. In aerial data acquisition a new era started with the introduction of the first real hybrid sensor systems, like the Leica CityMapper-2. Hybrid in this context means the combination of an (oblique) camera system with a topographic LiDAR into an integrated aerial mapping system. By combining these complimentary sub-systems into one system the weaknesses of the one system could be compensated by using the alternative data source. An example is the mapping of low-light urban canyons, where image-based systems mostly produce unreliable results. For an LiDAR sensor the geometrical reconstruction of these areas is straight forward and leads to accurate results. The paper gives a detailed overview over the development and technical characteristics of hybrid sensor systems. The process of data acquisition is discussed and strategies for hybrid urban mapping are proposed. A hybrid sensor alone is just a part of the whole procedure to generate 3D content. As important as the senor itself is the workflow to generate the products. Here again a hybrid approach, with the processing of all datasets in one environment, is discussed. Special attention is paid to the hybrid orientation of the data and the integrated generation of base and enhanced products. The paper is rounded off by the discussion of the advantage of LiDAR data for the 3D Mesh generation for urban modelling.
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Li, Xiangyang, Shuqiang Jiang und Jungong Han. „Learning Object Context for Dense Captioning“. Proceedings of the AAAI Conference on Artificial Intelligence 33 (17.07.2019): 8650–57. http://dx.doi.org/10.1609/aaai.v33i01.33018650.
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Dense captioning is a challenging task which not only detects visual elements in images but also generates natural language sentences to describe them. Previous approaches do not leverage object information in images for this task. However, objects provide valuable cues to help predict the locations of caption regions as caption regions often highly overlap with objects (i.e. caption regions are usually parts of objects or combinations of them). Meanwhile, objects also provide important information for describing a target caption region as the corresponding description not only depicts its properties, but also involves its interactions with objects in the image. In this work, we propose a novel scheme with an object context encoding Long Short-Term Memory (LSTM) network to automatically learn complementary object context for each caption region, transferring knowledge from objects to caption regions. All contextual objects are arranged as a sequence and progressively fed into the context encoding module to obtain context features. Then both the learned object context features and region features are used to predict the bounding box offsets and generate the descriptions. The context learning procedure is in conjunction with the optimization of both location prediction and caption generation, thus enabling the object context encoding LSTM to capture and aggregate useful object context. Experiments on benchmark datasets demonstrate the superiority of our proposed approach over the state-of-the-art methods.
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Ennishi, Daisuke, Christoffer Hoffer, Hennady Shulha, Anja Mottok, Pedro Farinha, Fong Chun Chan, Barbara Meissner et al. „Clinical Significance of Genetic Aberrations in Diffuse Large B Cell Lymphoma“. Blood 124, Nr. 21 (06.12.2014): 703. http://dx.doi.org/10.1182/blood.v124.21.703.703.
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Abstract Background: Although R-CHOP has significantly improved outcome in diffuse large B-cell lymphoma (DLBCL), 40% of patients still experience relapsed/refractory disease. Further investigation into the genomic architecture of DLBCL is needed to determine the biological correlates that underlie treatment failure. Recent studies using next-generation sequencing strategies have described the landscape of recurrent mutations in DLBCL. However, with the exception of TP53 and FOXO1, little is known about the clinical relevance of recurrent mutations and importantly, the interactions of these genetic alterations in DLBCL. Moreover, an integrated analysis of copy number alterations and recurrent mutations annotated across cell-of-origin (COO) distinctions for a large cohort of DLBCL cases who have received uniform therapy is lacking. The present study examined the frequency and clinical impact of recurrent genetic aberrations of DLBCL using high-resolution technologies in a large population-based DLBCL cohort. Methods: We analyzed 348 newly diagnosed DLBCL cases that were uniformly treated with R-CHOP at the BC Cancer Agency (Vancouver) with available DNA extracted from fresh frozen biopsy material (tumor content >30%). Matched germ line DNA was available for 67 patients. Comprehensive clinical annotation was available through the BCCA Lymphoid Cancer Database. Targeted re-sequencing of the coding exons of 56 genes was performed using a Truseq Custom Amplicon assay. Gene selection was based on mutational frequencies that have been previously described in DLBCL mutational landscape publications. High-resolution copy number analyses were performed using Affymetrix SNP 6.0 arrays. Tissue microarrays were constructed using duplicate 0.6mm cores from 332 cases, and breakapart FISH assays for MYC, BCL2 and BCL6 and IHC staining for MYC, BCL2 and cell of origin proteins were performed. COO classification was available in 331 cases, according to gene expression profiling by the Lymph2Cx assay using the NanoString platform (Scott, Blood 2014;123) in 299 patients as well as Hans algorithm (Hans, Blood 2004;103) in 32 cases with low tumor content. 194 cases were assigned to GCB subtype, 107 cases, ABC/non-GCB and 30 were unclassifiable. Results: In the mutation analysis, we identified 2,757 SNVs and 245 small indels. The mean depth of coverage was 634. Recurrent mutation frequencies varied between 0 and 58, with a mean of 8.25 per case. 98% of cases harbored at least one mutation and 95% of cases multiple mutations. 10 mutated genes were detected significantly more frequently in the GCB subtype including CREBBP, GNA13, EZH2, TNFRSF14, IRF8,STAT3, BCL2, SGK1, MEF2B and CD83, and 4 mutated genes, MYD88, CD79B, PRDM1 and PIM1, in the ABC subtype. In the copy number analysis, 45 significant amplification peaks and 57 deletion peaks were revealed by the GISTIC algorithm. As previously reported, 9p21.3, including CDKN2A,were more frequently detected in the ABC subtypes. With a median follow up of 6.5 years for living patients, the 5 y disease specific survival (DSS) and time to progression (TTP) of all patients were 72% and 64%, respectively. The clinical cohort was representative of registry data from BC based on a comparison of patient characteristics and survival outcomes with 1,194 control DLBCL R-CHOP patients. The ABC subtype was significantly associated with an inferior DSS and TTP (both p<0.0001). In univariate analyses we identified several gene mutations and copy number aberrations significantly associated with survival in all patients. Of these genes, MYD88 and TP53 mutations were associated with significantly inferior TTP in the ABC subtype (p=0.04) and GCB subtype (p=0.002), respectively, while TMEM30A, CREBBP, PIM1 and BTG1 mutations were associated with prognosis in DLBCL. Our analyses confirm the poor prognosis conferred by TP53 mutations in DLBCL and, importantly, identified several novel genetic alterations associated with survival stratified by COO distinctions. Conclusions: Our approach using next generation sequencing and high resolution SNP array provides an accurate estimation of frequency and clinical significance of recurrent genetic alterations of DLBCL in a uniformly R-CHOP-treated large population-based cohort of patients. Disclosures No relevant conflicts of interest to declare.
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Kang, Jae Shin. „Semiotic Approach for a Communication Analysis of Meme Content - Through Greimas' Semantic Generation Structure“. CONTENTS PLUS 18, Nr. 1 (28.02.2020): 23–39. http://dx.doi.org/10.14728/kcp.2020.18.01.023.
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Shehadeh, Amal, Alexander Felfernig, Martin Stettinger, Michael Jeran und Stefan Reiterer. „Automated Learning Content Generation from Knowledge Bases in the STUDYBATTLES Environment“. International Journal of Software Engineering and Knowledge Engineering 27, Nr. 09n10 (November 2017): 1387–408. http://dx.doi.org/10.1142/s0218194017400022.
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E-learning environments provide an orthogonal approach to transfer relevant knowledge. For example, sales representatives can improve their sales knowledge more independently from related courses offered. Major challenges for successfully establishing e-learning technologies in a company are to develop learning content in an efficient fashion, to recommend only relevant content to system users, and to motivate them to utilize the learning environment in a sustainable fashion. In this paper, we present the gamification-based e-learning environment STUDYBATTLES. We provide an overview of STUDYBATTLES functionalities including content creation, gamification techniques, learning performance analysis, and automated question generation. We show how STUDYBATTLES can be utilized for different learning purposes in academic and professional environments. In addition, we introduce an approach to automatically generate product and sales domain learning content from recommender knowledge bases to be exploited in STUDYBATTLES. Finally, we report the results of an initial qualitative study related to the applicability of STUDYBATTLES in different domains, the potential improvements that StudyBattles can achieve, and additional functionalities that should be integrated.
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Wijaya, Hadi, Rabab Alayham Abbas und . „Animation Effectiveness for E-Learning with Progressive Web App Approach: a Narrative Review“. International Journal of Engineering & Technology 7, Nr. 4.11 (02.10.2018): 112. http://dx.doi.org/10.14419/ijet.v7i4.11.20785.
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Understanding the content of a subject is the most fundamental thing a student should do to acquire the skills and knowledge. Animation is one way to provide an interesting way of learning. ALETRIA project is the reason to support the students for use animation methods that developed in novel e-learning concept. As a first step, the study of animation and e-learning development became the basis of this narrative literature. Terms of search that used in this paper is animation for learning, engagement and learner’s motivation. E-learning development with Progressive Web Apps (PWAs) were excluded from the search terms. 29 papers were selected for review as they are relevant to the criteria. The combined results of these papers recommend that there is reason to confident that the development of e-learning animations with the PWA approach might be effective to use.
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Silva, Pedro Brandão, Elmar Eisemann, Rafael Bidarra und António Coelho. „Procedural Content Graphs for Urban Modeling“. International Journal of Computer Games Technology 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/808904.
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Massive procedural content creation, for example, for virtual urban environments, is a difficult, yet important challenge. While shape grammars are a popular example of effectiveness in architectural modeling, they have clear limitations regarding readability, manageability, and expressive power when addressing a variety of complex structural designs. Moreover, shape grammars aim at geometry specification and do not facilitate integration with other types of content, such as textures or light sources, which could rather accompany the generation process. We present procedural content graphs, a graph-based solution for procedural generation that addresses all these issues in a visual, flexible, and more expressive manner. Besides integrating handling of diverse types of content, this approach introduces collective entity manipulation as lists, seamlessly providing features such as advanced filtering, grouping, merging, ordering, and aggregation, essentially unavailable in shape grammars. Hereby, separated entities can be easily merged or just analyzed together in order to perform a variety of context-based decisions and operations. The advantages of this approach are illustrated via examples of tasks that are either very cumbersome or simply impossible to express with previous grammar approaches.
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Conteduca, Vincenza, Daniel Wetterskog, Emanuela Scarpi, Alessandro Romanel, Giorgia Gurioli, Anuradha Jayaram, Cristian Lolli et al. „Circulating tumor DNA fraction (ctDNA) as a surrogate predictive biomarker in metastatic castration-resistant prostate cancer (mCRPC).“ Journal of Clinical Oncology 37, Nr. 15_suppl (20.05.2019): 5039. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.5039.
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5039 Background: Plasma ctDNA is a promising minimally invasive biomarker in mCRPC. Pre-treatment high levels of ctDNA reflect poor prognosis (Romanel et al, Sci Transl Med 2015; Annala et al, Cancer Discov 2018). However, the role of plasma ctDNA in prostate tumour monitoring is largely unexplored. We aimed to determine if monitoring tumour response by quantifying ctDNA levels in plasma could enable early assessment of therapy efficacy for mCRPC. Methods: Between January 2011 and June 2016, 132 sequential plasma samples from 54 mCRPC patients (pts) (30 pre- and 24 post-chemotherapy) treated with abiraterone (abi) were collected. Targeted next-generation sequencing was performed on the PGM Ion Torrent using a 316 or 318 Chip to account for 1000X expected coverage per target. We estimated the global tumour content for each sequential plasma sample from study patients by using the approach developed in (Carreira et al, Sci Trasl Med 2014; Romanel et al, Sci Transl Med 2015 ), which extends the CLONET framework (Prandi et al, Genome Biol 2014). Prostate Cancer Working Group -3 (PCWG3) criteria were used to assess clinical, biochemical (PSA) and radiographic (RAD) progression disease (PD). We considered ctDNA PD any increase of ctDNA from baseline value. Results: In our cohort of 54 pts (median age: 75 years, range 70-78), we observed 17 (31.5%) PD, 14 (25.9%) stable disease, and 23 (42.6%) partial/complete response after the first 3 months (mo) abi therapy. The odds ratio (OR) for PD having any increase in ctDNA and a PSA decline < 50% at ~3-mo therapy was 10.83, 95% CI 2.55-45.95, P = 0.001, and 3.27, 95% CI 0.89-12.3, P = 0.074, respectively. In addition, we assessed all 3 types of median PD time from starting abi treatment, suggesting the ability of ctDNA variation to predict overall PD [RAD PD = 6.8 mo, PSA PD = 4.4 mo, and ctDNA PD = 3.0 mo, P = 0.008). An increase of ctDNA levels during the first 3-mo abi treatment was significantly associated with a long-term androgen deprivation therapy (ADT) before plasma sample collection (previous ADT > 24 mo vs 12 > previous ADT ≤23 mo vs < 12 mo: P = 0.036). Conclusions: In mCRPC, an early change in ctDNA fraction may be considered as a predictive biomarker playing a key role in individualized disease monitoring. Prospective evaluation of treatment decisions based on ctDNA is now required.
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Trabucco, Sally E., Ethan S. Sokol, Jay A. Moore, Sophia Maund, Garrett M. Frampton, Vincent A. Miller, Jeffrey Venstrom et al. „Prediction and Characterization of Diffuse Large B-Cell Lymphoma (DLBCL) Cell of Origin (COO) Subtypes Using Genomic Features from Targeted Next-Generation Sequencing“. Blood 132, Supplement 1 (29.11.2018): 1561. http://dx.doi.org/10.1182/blood-2018-99-116677.
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Abstract Introduction: DLBCL has two COO subtypes: Activated B Cell (ABC) and Germinal Center B cell (GCB). Patients with the ABC subtype have a poor prognosis compared to those with GCB, and COO can be predictive for response to some new therapeutic agents. Traditionally, COO subtype has been determined by microarray (ABC, GCB, unclassified), IHC-based algorithms (GCB or non-GCB), or expression-based Nanostring Lymph2Cx (ABC, GCB, unclassified). Some reports have failed to show a prognostic difference between GCB and non-GCB when employing IHC-based algorithms. This has led some to adopt the Lymph2Cx assay as the preferred method to assess COO, but in some cases the tumor content or RNA quality is inadequate to perform this assay. COO subtypes have differing gene mutations, with GCB typically characterized by EZH2 alterations and IGH:BCL2 translocations, while ABC is dominated by NF-KB and BCR signaling alterations such as MYD88 and CD79B short variants. Here we utilized mutational differences in COO subtypes to develop a COO DNA classification (COODC) model to predict COO from DNA-based features on a clinically utilized platform. Methods: Comprehensive genomic profiling (CGP) of DLBCL samples was performed using the DNA component of the FoundationOne® Heme platform; sequencing 465 genes for the GOYA trial (R-CHOP vs G-CHOP; N=499; NCT01287741), MAIN trial (R-CHOP +/- bevacizumab; N=44; NCT00486759), and cases from routine clinical care (FM-clinical; N=597). Gold standard COO classifications were determined in GOYA using the Lymph2Cx assay, and in MAIN using a modified Wright algorithm applied to a custom Nanostring expression panel. COODC was developed using a penalized lasso regression with 25-fold internal cross validation and cutoffs that optimize specificity and sensitivity. Concordance was calculated as the percentage of COODC calls matching the gold standard, excluding samples called unclassified in the gold standard or COODC. Results: We developed a novel DNA-based method to determine COO, which is 89% concordant with Lymph2Cx (Table) COODC was trained on 296 GOYA samples with Lymph2Cx COO calls and validated on 139 held-out samples from the same cohort (GOYA). Additional validation was performed on an independent first-line cohort (MAIN) and confirmed a high concordance (92%). COODC also provides prognostic value, confirming the worse prognosis of ABC (progression-free survival [PFS] hazard ratio [HR] 1.6; 95% confidence interval [CI]: 1.1-2.4; p=0.011) and unclassified (PFS HR 1.9; 95% CI: 1.1-3.2; p=0.021) compared with GCB. This approach also allows investigation into the genomics and underlying features of COO subtypes. Alterations in BCL2, EZH2, and TNFRSF14 were important determinants of the GCB phenotype, consistent with the enrichment of GCB samples among the EZB cluster in Schmitz et al. (N Engl J Med 2018), or C3 in Chapuy et al. (Nat Med 2018). Alterations in MYD88 and CD79B were highly predictive of ABC subtype, as expected. Alterations in NOTCH1, NOTCH2, and BCL6 were all slightly predictive of ABC subtype, despite the mixed phenotype of the BN2, N1 (Schmitz et al. N Engl J Med 2018), and C1 (Chapuy et al. Nat Med 2018) groups. Novel features include decreased average copy number of chromosome 6p, which encodes the HLA locus, in ABC (p=0.0064), and increased frequency of T>A and T>G alterations in GCB (p<0.0001 for both). We identified 2 major mutational signatures associated with COO: COSMIC signature 23, corresponding to a canonical activation-induced cytidine deaminase signature, enriched in ABC (p=0.002), and COSMIC signature 3, which trends to increased frequency in GCB (p=0.13). Conclusions: We have developed a new and clinically relevant method for determining DLBCL COO in specimens with tumor purity as low as 20%, without the need for RNA or matched normal tissue. This method is 89% (GOYA) to 92% (MAIN) concordant with the Lymph2Cx assay and maintains prognostic value. Integrating COO with CGP enables insights into disease biology, including the identification of novel features associated with COO. We identified a difference in mutational signatures between ABC and GCB, suggesting that different origin cells may contribute to different mutational processes. Disclosures Trabucco: Foundation Medicine Inc: Employment. Sokol:Foundation Medicine: Employment. Moore:Foundation Medicine, Inc.: Employment. Maund:Genentech: Employment. Frampton:Foundation Medicine Inc: Employment, Other: Employee and stockholder. Miller:Foundation Medicine: Employment, Other: Ownership interests none PLC*; Revolution Medicines: Membership on an entity's Board of Directors or advisory committees. Venstrom:Genentech Inc: Employment. Albacker:Foundation Medicine Inc: Employment; Foundation Medicine Inc: Employment. Sehn:Morphosys: Consultancy, Honoraria; Seattle Genetics: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Lundbeck: Consultancy, Honoraria; TG Therapeutics: Consultancy, Honoraria; Merck: Consultancy, Honoraria; Roche/Genentech: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Janssen: Consultancy, Honoraria. Oestergaard:Roche: Employment, Other: Ownership interests PLC. Bolen:Roche: Other: Ownership interests PLC*.
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Chiabrando, F., E. Donadio und F. Rinaudo. „SfM for Orthophoto to Generation: A Winning Approach for Cultural Heritage Knowledge“. ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XL-5/W7 (11.08.2015): 91–98. http://dx.doi.org/10.5194/isprsarchives-xl-5-w7-91-2015.
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3D detailed models derived from digital survey techniques have increasingly developed and focused in many field of application. The high detailed content and accuracy of such models make them so attractive and usable for large sets of purposes in Cultural Heritage. The present paper focuses on one of the main techniques used nowadays for Cultural Heritage survey and documentation: the image matching approach or Structure from Motion (SfM) technique. According to the low cost nature and the rich content of derivable information, these techniques are extremely strategic in poor available resources sectors such as Cultural Heritage documentation. <br><br> After an overview of the employed algorithms and used approaches of SfM computer vision based techniques, the paper is focused in a critical analysis of the strategy used by two common employed software: the commercial suite Agisoft Photoscan and the open source tool MicMac realized by IGN France. The experimental section is focused on the description of applied tests (from RPAS data to terrestrial acquisitions), purposed to compare different solutions in various featured study cases. Finally, the accuracy assessment of the achieved products is compared and analyzed according to the strategy employed by the studied software.
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Tejaswini. „Male gametophytic generation and a possible approach for selective pollination in carnation (Dianthus) breeding program“. Plant, Soil and Environment 48, No. 8 (21.12.2011): 368–75. http://dx.doi.org/10.17221/4382-pse.
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Present study focuses on making best possible use of male gametophytic generation in carnation breeding program. Exploration of pollen population revealed the existence of variability in terms of pollen morphology and histochemical content among as well as within varieties and species of Dianthus caryophyllus and D. chinensis sufficient to make selection. Pollen grain size and histochemical content were found to be associated with germination capacity and pollen tube growth rate. In addition, pollen germination capacity and elongation of pollen tube in response to presence of culture filtrate from F. oxysporum. f.sp. dianthi causal organism of fusarium wilt in carnation was found to be governed by pollen grain size and histochemical content of pollen grains. Entire result suggests the possibility of selecting the desired pollen grains from a pollen population and possibility of attempting selective pollination in carnation breeding program.
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Gracia, Narissa, Anna F. Rumbach und Emma Finch. „A survey of speech-language pathology treatment for non-progressive dysarthria in Australia“. Brain Impairment 21, Nr. 2 (17.03.2020): 173–90. http://dx.doi.org/10.1017/brimp.2020.3.
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AbstractAim:To identify management practices of Australian speech-language pathologists (SLPs) in the treatment of non-progressive dysarthria using a subsystem approach, and to explore SLPs’ consideration and implementation of the theoretical underpinnings of non-progressive dysarthria management.Method:A 39-item online survey was distributed to Australian SLPs, with 80 responses suitable for data analysis.Results:Practices of SLPs were variable for the management of the speech subsystems. The Lee Silverman Voice Treatment (LSVT®) was the most commonly used manualised treatment program, and was employed by 63.77% of respondents. Almost all SLPs (>88%) provided strategies to improve functional communication. There was no clear preference for low tech alternative and augmentative communication (AAC) devices. Speech generating devices were the most commonly employed high tech device. Almost two-thirds of respondents used non-speech oral motor exercises (NSOMEs) in treatment. SLPs had varied frequencies and models of service delivery for intervention. SLPs valued interventions targeting the activity and participation domains of the ICF, however this was restricted by the treatment context and resources available. The majority of SLPs (92.06%) were aware of the principles of motor learning, however many were unsure regarding the specifics of implementation.Conclusion:There is a clear need for further research into the efficacy of treatment techniques to guide decision-making.