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Thematische Bibliographien / Pregnancy Complications

Auswahl der wissenschaftlichen Literatur zum Thema „Pregnancy Complications“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 9. März 2023

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Dissertationen
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Buchteile
Konferenzberichte
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Zeitschriftenartikel zum Thema "Pregnancy Complications":

1

Kochar Kaur, Kulvinder. „Endometriosis and Pregnancy - Associated Complications“. Open Access Journal of Gynecology 3, Nr. 3 (2018): 1–2. http://dx.doi.org/10.23880/oajg-16000164.

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2

Murugaboopathi, Sindhuja, und Hephzibah Kirubamani. „Awareness of Complications of First Trimester Pregnancy“. Indian Journal of Obstetrics and Gynecology 7, Nr. 4 (P-2) (2019): 627–31. http://dx.doi.org/10.21088/ijog.2321.1636.7419.9.

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3

Aslam Ahsan, Dr Muhammad, und Dr Muhammad Rafique Cheema. „PREGNANCY; THROMBOEMBOLIC COMPLICATIONS“. PROFESSIONAL MEDICAL JOURNAL 23, Nr. 03 (01.03.2016): 284–87. http://dx.doi.org/10.17957/tpmj/16.2952.

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4

NYBERG, DAVID A., LAURENCE A. MACK, FAYE C. LAlNG und R. BROOKE JEFFREY. „Early Pregnancy Complications“. Obstetrical & Gynecological Survey 44, Nr. 2 (Februar 1989): 108–11. http://dx.doi.org/10.1097/00006254-198902000-00005.

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5

Gnanasambanthan, Sai, und Shree Datta. „Early pregnancy complications“. Obstetrics, Gynaecology & Reproductive Medicine 29, Nr. 2 (Februar 2019): 29–35. http://dx.doi.org/10.1016/j.ogrm.2018.12.011.

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6

Taghiyeva, A., L. Kiliç, M. Cagan, E. C. Bolek, G. K. Yardimci, O. Karadag, O. Ozyuncu und Ş. A. Bilgen. „POS0813 FERTILITY AND PREGNANCY OUTCOMES IN TAKAYASU’S ARTERITIS“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 659–60. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3231.

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Background:Takayasu’s arteritis (TA) is commonly seen in women of childbearing ages; therefore, reproductive health of TA patients is an important issue.Objectives:We aimed to evaluate the fertility and pregnancy (PG) outcomes of TA patients before and after diagnosis.Methods:In the prospective database of the Hacettepe University Vasculitis Research Centre (HUVAC), 202 TA patients (female =184) meeting the 1990 ACR criteria were registered by the end of February 2020. 120 patients who could be reached out gynaecological records and marriage status, were included in the study. We identified 233 PG in 82 of included these 120 TA patients (Figure 1). Demographic and clinical features, comorbidities, distribution of vascular involvement, obstetrical histories and outcomes were retrospectively evaluated. Patients were classified according to a novel proposed disease clusters (C1: Abdominal Predominant, C2: Aortic Arch Predominant, C3: Focal Disease) using the defined decision tree.Results:12 of 96 (12.5%) married TA patients had infertility being defined as not being able to get pregnant after one year (or longer) of unprotected sex. 20 (16.7%) women had menopause before the age of 45, being defined as early menopause (EM). Compared to normal population, infertility (12.5% vs. 8.1%) and EM ratios (16.7% vs. 7.6%) seem to be increased in TA patients. (1, 2)200 PG had occurred before TA diagnosis (bTA) in 71 women, and 33 PG were observed after TA diagnosis (aTA) diagnosis in 19 women (two patients diagnosed during PG). According to novel disease subsets, aTA patients classified into C1 (n=3; 15.7%), C2 (n=9; 47.3%) and C3 (n=6; 31.5%). One patient could not be classified.GHT was seen in 4 (12.1%) patients being the most frequent maternal complication in aTA group. Most common fetal complications were prematurity, IUGR and LBW in both groups (Table 1). Even fetal complications were more frequent in aTA group, it was not statistically significant [11 (33.3%) vs. 43 (21.5%), p=0.18 respectively]. However, maternal complications were significantly more common in aTA group [22 (11.0%) vs. 8 (24.2%), p=0.048]. There was no difference for the obstetrical outcomes in terms of novel TA classification.Conclusion:This study showed increased infertility and EM ratios in TA patients. PG of aTA had more complications in terms of maternal complications. Fetal complications were more frequent in PG of aTA but not statistically significant. Larger cohort data is required.References:[1]doi:10.1017/s0021932017000244.[2]doi:10.1016/j.maturitas.2019.03.008.PregnanciespBefore TA (n=200)After TA (n=33)Number of Patients7119NPAge at TA diagnosis, years mean (SD)38.2 (13.1)24.0 (6.6)Age at first pregnancy21.7 (5.0)27.6 (5.0)Comorbidities/CV Risk factors n(%)n (%)p- Smoking22 (31)3 (15.8)>0.05- Dyslipidemia14 (19.7)1 (5.3)- Hypertension29 (40.8)9 (47.4)- Diabetes mellitus8 (11.3)0 (0)Maternal Complicationsn (%)Numbers of pregnancies with any maternal complications22 (11.0)8 (24.2)0.048- Gestational hypertension6 (3.0)4 (12,1)NP- PROM6 (3.0)1 (3.0)- GDM0 (0)0 (0)- Bleeding (Antepartum/postpatum)6 (3.0)2 (6.1)- Preeclampsia0 (0.0)0 (0.0)- İnfection5 (2.5)1 (3.0)- Placenta previa0 (0)1 (3.0)Fetal Complicationsn (%)pNumbers of pregnancies with any fetal complications43 (21.5)11 (33.3)0.180- LBW16 (8.0)6 (18.2)NP- IUGR20 (1.0)5 (15.2)- Preterm birth13 (6.5)7 (21.2)- CNS complications2 (1.0)1 (3.0)- Cardiovascular complications3 (1.5)0 (0)- RDS_BPD4 (2.0)0 (0)- NICU admission12 (6.0)1 (3.0)- Other5 (2.5)0 (0)- Neonatal death5 (2.5)0 (0)- Retinopathy of prematurity1 (0.5)0 (0)- Stillbirth7 (3.5)0 (0)Deliveryn (%)PVaginal delivery128 (64)6 (18.2)<0.001Cesarean24 (12)13 (39.4)<0.001Spontaneous abortus21 (10.5)7 (21.2)0.088Termination of pregnancy18 (9.0)7 (21.2)0.061Abbreviations: BPD: Bronchopulmonary dysplasia, CNS: Central nervous system, GDM: Gestational diabetes mellitus, IUGR: Intrauterin growth restriction, LBW: Low birth weight, NICU: Neonatal Intensive Care Unit, NP: Not performed PROM: Premature rupture of membranes, RDS: Respiratory distress syndromeDisclosure of Interests:None declared

7

VK, Sita, und N. Hephzibah Kirubamani. „Awareness on Complications of Fever in Early Pregnancy“. Indian Journal of Obstetrics and Gynecology 7, Nr. 3 (P-2) (2019): 487–93. http://dx.doi.org/10.21088/ijog.2321.1636.7319.20.

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8

Junagam, Sreeman N., und Balu Jatthavath. „EVALUATION OF LIVER ENZYMES IN PREGNANCY WITH COMPLICATIONS“. International Journal of Integrative Medical Sciences 5, Nr. 6 (05.07.2018): 659–62. http://dx.doi.org/10.16965/ijims.2018.119.

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9

Middeldorp, Saskia. „Anticoagulation in pregnancy complications“. Hematology 2014, Nr. 1 (05.12.2014): 393–99. http://dx.doi.org/10.1182/asheducation-2014.1.393.

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Abstract Women with acquired and inherited thrombophilia are thought to be at increased risk for pregnancy complications, including recurrent pregnancy loss and, depending on the type of thrombophilia, severe preeclampsia. This review discusses the associations between the types of thrombophilia and types of complications, as well as the currently available clinical trial evidence regarding the use of aspirin and heparin to prevent these pregnancy complications. In women with antiphospholipid syndrome, guidelines recommend prescribing aspirin and heparin to women with recurrent miscarriage. The same regimen is suggested for late pregnancy complications by some, but not all, experts. Aspirin or low-molecular-weight heparin to improve pregnancy outcome in women with unexplained recurrent miscarriage has no benefit and should not be prescribed. Whether anticoagulant therapy prevents recurrent miscarriage in women with inherited thrombophilia or in women with severe pregnancy complications remains controversial because of inconsistent results from trials. Aspirin modestly decreases the risk of severe preeclampsia in women at high risk.

10

Kashif, Uzma, Nadia Riaz, Swapna Percholli Ramasubramanian und David Iles. „Urogynaecological complications in pregnancy“. Obstetrics, Gynaecology & Reproductive Medicine 31, Nr. 2 (Februar 2021): 42–47. http://dx.doi.org/10.1016/j.ogrm.2020.12.004.

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Dissertationen zum Thema "Pregnancy Complications":

1

Benton, Samantha Jayne. „Angiogenic factors in placentally-mediated pregnancy complications“. Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50014.

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Placentally-mediated pregnancy complications include pre-eclampsia, intrauterine growth restriction (IUGR), placental abruption and some causes of stillbirth. These complications are believed to arise from abnormal placental development in early gestation that leads to compromised placental function in later pregnancy which can adversely affect both mother and fetus. It is a priority in obstetrics to identify these pregnancies early and accurately so that appropriate monitoring and intervention can optimise outcomes for these mothers and babies. Novel biomarkers such as angiogenic factors in the maternal circulation may improve the prediction and/or diagnosis of these complications by adding to the information gained from tools already used in clinical practice. In this thesis, I investigated angiogenic factors in 1) the diagnosis of pre-eclampsia using new clinical immunoassays, 2) the prediction of placentally-mediated complications in a high-risk pregnancy cohort and 3) the diagnosis of placental IUGR in pregnancies with small for gestational age (SGA) fetuses. Additionally, I investigated the association between levels of circulating angiogenic factors and the presence of histopathological lesions of dysfunction in the placenta after delivery. I found that angiogenic factors, particularly low circulating placental growth factor (PlGF), had high sensitivity and specificity in the diagnosis of pre-eclampsia but all markers had poor performance as predictive markers for placentally-mediated complications. In pregnancies with SGA fetuses, low maternal PlGF discriminated between fetuses with placental IUGR (defined by the presence of histological lesions of placental dysfunction) from constitutionally small fetuses (no pathological lesions present) with high sensitivity and high negative predictive value. Additionally, low maternal PlGF in the second trimester was associated with the presence of lesions of placental dysfunction in pregnancies at high-risk for placentally-mediated complications. Low maternal PlGF was also associated with lesions of placental dysfunction as well as altered placental morphology in pregnancies with SGA fetuses. Taken together, these findings suggest that PlGF may be an antenatal marker of placental dysfunction and may provide a novel clinical tool to identify pregnancies with placental dysfunction. This work improves our understanding of angiogenic factors in placentally-mediated complications and contributes to the growing body of evidence supporting their integration in clinical practice.
Medicine, Faculty of
Obstetrics and Gynaecology, Department of
Graduate

2

ElMoursi, Mohamed Saad Elsayed. „Quantification of placental dysfunction in pregnancy complications“. Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17262/.

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Background The pathogenetic mechanisms behind placental dysfunction-related complications like preeclampsia and intrauterine growth restriction have remained perplexing till now, in part because of lack of well-defined structural and functional molecular characterisation. There is growing evidence that links trophoblast debris and the existence of syncytial nuclear aggregates (SNA) to the pathogenesis of gestational diseases. Characterisation and quantification of structural and functional parameters of placental dysfunction may give researchers a clearer picture of the mechanisms underlying the development of high risk pregnancy. Methods Placental samples were obtained from normal term pregnancies, preterm controls, as well as from pregnancies complicated by preeclampsia (PET), intrauterine growth restriction (IUGR) and PET-IUGR. Formalin-fixed, paraffin-embedded sections were visualised with H&E, stained using immunohistochemistry (IHC) and digitally scanned. Using stereological methodology, volumes of placental SNAs, trophoblasts, villi and capillaries were measured. Three dimensional (3D) volume reconstructions of terminal placental villi with SNAs and fibrinoid degenerations were created. IHC-labelled slides were analysed by image analysis algorithms. Differential expression of placental genes and miRNAs, hypothesised to regulate cell death in placental dysfunction, were quantified using RT-qPCR. BeWo cell lines were carried out for in vitro validation of the effects miRNAs regulating programmed cell death (PCD) using flow cytometry and western blotting. Results Specific morphometric patterns of villous, trophoblasts, SNA and capillary volumes were demonstrated with characteristic higher SNAs and lower capillary volumes in PET placentae with reciprocal patterns in IUGR placentae showing a negative correlation pattern between nuclear aggregates and capillary volumes. Image analysis of immune-labelled slides showed a higher autophagy marker expression in PET and a positive correlation to SNAs as well as a balanced reciprocal expression patterns with apoptosis. Moreover, miR-204 transfected BeWo cells showed a similar balanced reciprocal regulation of autophagy and apoptosis expressions. Conclusion We have demonstrated that applying stereology-based and image analysis on digitised placental sections can be useful in quantifying and dissecting structural and functional patterns in normal and abnormal placental function. 3D reconstruction model are a novel approach towards placental characterisation in normal and complicated pregnancies. The study also showed that miR-204 plays a vital role in the regulation of placental autophagy and apoptosis, critical in the pathophysiology of placental dysfunction.

3

Rodie, Vanessa Angela. „Metabolic complications of pregnancy and cardiovascular disease risk“. Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421118.

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Demetriou, Charalambos. „Investigating genetic factors associated with complications of pregnancy“. Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/30728.

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This PhD project sets out to investigate the role of genetic factors associated with fetal growth restriction and recurrent miscarriage (RM), two of the most common complications of pregnancy. This work studied large cohorts of patients collected from specialist clinics in West London with the aim of better understanding their underlying molecular aetiology. The first part of this project focused on the paternally expressed, maternally imprinted gene, IGF2, which is a key growth hormone critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only been studied in term tissues. mRNA expression levels of IGF2 and other genes were investigated in 260 chorionic villus samples collected at 11-13 weeks' gestation. Transcript levels of IGF2 revealed a significant positive correlation with birth weight (P=0.009). Critically, small for gestational age neonates had significantly lower IGF2 levels than appropriate for gestational age neonates (P=3.6x10-7). Next a study was undertaken to investigate a potential role for disturbed imprinting in products of conception (POC). This work first involved a detailed analysis of the POC DNA to establish levels of maternal cell contamination. POCs could then be more accurately evaluated to investigate the status of known imprinted genes. Interestingly, in a number of POCs, known maternally expressed genes were found to be paternally expressed and vice versa. This suggested that some miscarriages might be associated with or even caused by abnormal imprinting. Two approaches were then used to study genetic factors associated with RM. The first involved a genetic association study with a placental anti-coagulant protein Annexin A5 that contains four nucleotide substitutions (M2 haplotype) in its promoter. Patient and control haplotypes were determined and compared in 500 White European pairs that had RMs and 250 control trios. Carriers of the M2 haplotype were found to exhibit higher RM risk than non-carriers, which was in agreement with previous studies. However, this is only true for the patients who suffered with early miscarriages. The second study involved analysis of a single family where the patient had experienced a total of 29 miscarriages but had no successful pregnancies. Next-generation exome sequencing was carried on family members to search for a potential rare genetic variant gene causative of the RM phenotype. Two candidate genes with potentially damaging mutations were investigated in more depth by sequencing them in cohorts of Asian RM patients (n=100) and White European RM patients (n=120). In one of the genes, three novel variants and one very rare SNP, which were all predicted to be damaging by different prediction programs, were identified in a total of four Asian patients. Future studies to further investigate these potential mutations, involves functional analysis of each variant such as site-directed mutagenesis and protein-protein interactions.

5

Bayingana, Claude. „The prevalence of members of the "red complex" in pregnant women as revealed by PCR and BANA hydrolysis“. Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Increased levels of oestrogen and progesterone during pregnancy may lead to periodontal disease. The anaerobic Gram-negative bacteria called red complex (Porphyromonas gingivalis, Tannerella forsythensis and Treponema denticola) are frequently associated with periodontal disease. Periodontopathogens produce toxins and enzymes which can enter the bloodstream and cross the placenta to harm the foetus. The response of the mother&rsquo
s immune system to infection by these periodontopathogens, brings about the release of inflammatory mediators which may trigger preterm labour or result in low birth-weight infants. The purpose of this study was to examine the prevalence of red complex, using BANA and PCR in subginginval plaque samples from pregnant women. Subgingival plaque samples were obtained from pregnant women between the ages of 17 to 45 years attending a Mitchells Plain ante-natal clinic. Plaque samples were analyzed by the enzymatic BANA-test for detection of the presence of red complex and DNA was extracted and analyzed using 16 rDNA-Polymerase Chain Reaction (PCR).

Seventy-nine percent of pregnant women showed gingival index scores of &ge
1 of which 74.24% harboured by at least one of the members of the red complex. P.gingivalis was the most prevalent of the three members of the red complex. Findings of this study confirmed a need for dental preventive measures in pregnant women and microbial monitoring of suspected periodontopathogenes. This could be achieved by joint cooperation between Maternity Obstetric Units (MOU), Dentistry and oral microbiology departments. The results of this study revealed that although PCR is more sensitive than BANA in detecting members of the red complex, BANA showed a better association with the indices used to diagnose periodontal disease.

6

Björklund, Anders. „Hypoglycaemia in pregnancy : hypoglycaemic clamp studies during and after pregnancy in women with IDDM /“. Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980605bjor.

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Wilkerson, Diana Sue. „Perinatal complications as predictors of infantile autism“. Virtual Press, 1992. http://liblink.bsu.edu/uhtbin/catkey/833467.

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This study investigated the impact of perinatal complications on the developing child and the relationship of those complications to the development of autism in an individual. The biological mothers of autistic children (N = 183) completed the Maternal Perinatal Scale, a maternal selfreport which surveys complications of pregnancy and medical conditions of the mother. Archival data on normals (N = 209), obtained during previous perinatal investigations, was utilized as a control group.Previous research in this area has been limited, with no definitive conclusions. All previous investigators have declined to state that events identified in previous research were definitely related to the development of autism.An overall multivariate test was performed to determine if significant differences existed between the autistic and normal subjects. Following this exploration of the data, previously identified complications were entered into a stepwise discriminant analysis in the order of theirtheoretical importance to determine the extent of their contribution to autism. Following this analysis, medical conditions of the mothers (items 27-47 as included on the MPS) were entered into the stepwise analysis to determine their contribution, if any, to autism in the sample.The results of this analysis revealed that the two groups differed significantly on three of the ten factors of the MPS. The overall multivariate test was highly significant and revealed that the groups differed on Factor 2 (Gestational Age), Factor 4 (Maternal Morphology), and Factor 8 (Intrauterine Stress). Moreover, five of the six previously identified items were found to be significant. These were: prescriptions raken during pregnancy, length of labor, viral infection,, abnormal presentation at delivery, and low birthweight. Three of the maternal medical conditions examined were also highly significant and contributed to separation between groups. These were: urinary infection, high temperatures, and depression. These were items which have not been identified in previous investigations.Based on discriminant analysis of the 10 factors of the MPS, 65% of the cases were correctly grouped. The MPS would be a useful clinical tool in identification of those children who are at risk for development of autism.
Department of Educational Psychology

8

Walker, Kate Frances. „Late pregnancy complications in women of advanced maternal age“. Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.718852.

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The age of childbearing is rising in women living in industrialised nations. Advanced maternal age is associated with a small increased risk of term antepartum stillbirth. Labour induction would likely reduce stillbirth, but might also increase Caesarean delivery, already high for older women. The aim of this thesis was to design and conduct a randomised controlled trial of induction of labour at 39 weeks versus expectant management for nulliparous women aged over 35 years. In total 619 women participated and the trial showed that induction of labour has no adverse short-term effects on maternal or neonatal outcomes. In particular, it does not increase caesarean section rate. A cost-utility analysis of the trial was performed and demonstrated that induction of labour is associated with a small gain in QALYs and is not more expensive than expectant management. One key secondary outcome of the trial was maternal satisfaction. There is a lack of a robust validated tool for evaluating labour experience in the UK therefore a study of 350 women was performed to validate a Swedish instrument (Childbirth Experience Questionnaire) in the UK. This study demonstrates that the Childbirth Experience Questionnaire is a valid and reliable measure of childbirth experience in the UK population. A study examining the causes of 2850 cases of antepartum stillbirth in women of advanced maternal age using anonymised national data found that stillbirths in women over 35 years old are more likely to be due to major congenital anomalies, mechanical causes, maternal disorders or associated obstetric factors than women less than 35. In 2013, a systematic review of randomised controlled trials of induction of labour versus expectant management at term found that a policy of induction was associated with a 17% reduction in the risk of caesarean section. An IPD meta-analysis of induction of labour versus expectant management at term in women with intact membranes by subgroups of maternal age has shown that induction in women of advanced maternal age has no statistically significant effect on caesarean section rates.

9

Syngelaki, Argyro. „Screening for pregnancy complications at 11-13 weeks' gestation“. Thesis, Manchester Metropolitan University, 2015. http://e-space.mmu.ac.uk/595938/.

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Background: The current approach to prenatal care, which was established more than 80 years ago, is characterised by a high concentration of visits in the third-trimester of pregnancy which implies that firstly, most complications occur at this late stage of pregnancy and secondly, most adverse outcomes are unpredictable during the first or even the second trimester. Objectives: The objective of this thesis is to provide evidence that most pregnancy complications are predictable as early as 12 weeks’ gestation. The pregnancy complications examined include fetal aneuploidies, fetal structural defects, preeclampsia, preterm birth, gestational diabetes mellitus and fetal macrosomia. Methods: I have critically examined fourteen articles reporting on screening for pregnancy complications at 11-13 weeks’ gestation, where more than 90,000 singleton pregnancies were prospectively assessed at 11-13 weeks’ gestation as part of a routine prenatal visit for screening for trisomy 21. We recorded a series of maternal characteristics and history, measured maternal weight and height, performed a detailed ultrasound examination of the fetus, measured maternal uterine artery Doppler pulsatility index and maternal mean arterial pressure and collected blood for analysis of biomarkers for prospective or retrospective analysis. All data were prospectively entered into our data base as well as the pregnancy outcomes as soon as they became available. Ethical approval was obtained for these studies. Multivariate regression analysis was used to define the contribution of each maternal characteristic and history in predicting each adverse outcome and those with a significant contribution formed an algorithm to estimate the background risk (a priori risk) for each one of these complications. The potential value of biophysical and biochemical markers in improving the performance of the a priori risk in predicting adverse pregnancy outcomes, was evaluated. Results: First trimester effective screening for adverse pregnancy outcomes was provided by a combination of maternal factors and biophysical or biochemical markers. The developed predictive models could correctly identify the vast majority of aneuploidies, early preeclampsia and more than half of the cases of spontaneous preterm birth and gestational diabetes. First trimester prediction of fetal macrosomia was less effective compared with other complications. First trimester examination of fetal anatomy was feasible resulting in a high detection of fetal non-chromosomal defects, including more than half of fetal cardiac defects. Conclusions: Assessment of the mother and fetus at 11-13 weeks’ gestation can provide effective early identification of the high risk group of pregnancies with fetal and maternal adverse outcomes.

10

Chaudhry, Shazia Hira. „The Association of Homocysteine with Placenta-Mediated Pregnancy Complications“. Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39425.

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Background: Preeclampsia, small for gestational age (SGA), placental abruption, and fetal death are pregnancy complications linked to the utero-placental vasculature with serious consequences for maternal and infant well-being. Elevated homocysteine, a marker of cardiovascular disease risk, is postulated to play a role in placenta-mediated complications, but epidemiologic studies have reported inconsistent findings. The two primary objectives of this thesis were to 1: comprehensively investigate the association of homocysteine with placenta-mediated complications and examine modifying effects of pre-specified factors on this association, and 2: comprehensively investigate determinants of maternal homocysteine during pregnancy. Methods: A systematic review and meta-analysis of prospective studies was conducted to address thesis objective 1. The Ottawa and Kingston (OaK) Birth Cohort, a prospective cohort study that recruited pregnant women between 2002 and 2009, was used to address thesis objectives 1 and 2. Homocysteine concentration was measured between 12 and 20 weeks gestation. Analyses based on the OaK Birth Cohort consisted of multivariable regressions using restricted cubic splines to model associations with continuously distributed variables. Results: Objective 1: In an analysis of 7587 participants, a significant association between homocysteine concentration and a composite outcome of any placenta-mediated complication was observed (odds ratio (OR) for a 5 µmol/L increase: 1.63, 95% Confidence Interval (CI) 1.23-2.16) and SGA (OR 1.76, 95% CI 1.25-2.46), with potential modifying effects of the methylene tetrahydrofolate reductase (MTHFR) 677C>T variant (SGA) and high-risk pregnancy (preeclampsia). In the systematic review identifying 30 prospective cohort or nested case-control studies, a random effects meta-analysis of pooled mean differences in homocysteine between cases and controls in 28 studies revealed significantly higher means for SGA: 0.35 µmol/L (95% CI 0.19 to 0.51, I2=33%); and preeclampsia: 0.87 µmol/L (95% CI 0.52 to 1.21, I2=92%). Significant sources of heterogeneity were study region (SGA and preeclampsia), adjusting for covariates (preeclampsia), folate status (preeclampsia), and severity (preeclampsia). Objective 2: In 7587 OaK participants, factors related to favourable health status were associated with lower maternal homocysteine concentrations. Folic acid supplementation during pregnancy of >1 mg/day did not substantially increase serum folate concentration. Conclusion: This thesis suggests an independent effect of slightly higher homocysteine concentration in the early to mid-second trimester on the risk of any placenta-mediated complication, SGA, and preeclampsia. Modifying effects explain some of the variability in previous studies. Favourable preconception health status was associated with lower maternal homocysteine.

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Bücher zum Thema "Pregnancy Complications":

1

N, Canfield Richard, Hrsg. Infectious pregnancy complications. Hauppauge, NY: Nova Science Publishers, 2009.

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2

1933-, Burrow Gerard N., Duffy Thomas P und Copel Joshua A, Hrsg. Medical complications during pregnancy. 6. Aufl. Philadelphia: Elsevier Saunders, 2004.

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3

Peeters, L. L. H., P. W. de Leeuw und E. D. Post Uiterweer. Pathophysiology of pregnancy complications. Houten: Bohn Stafleu van Loghum, 2021. http://dx.doi.org/10.1007/978-90-368-2571-9.

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1933-, Burrow Gerard N., und Ferris Thomas F. 1930-, Hrsg. Medical complications during pregnancy. 3. Aufl. Philadelphia: Saunders, 1988.

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5

D, Craigo Sabrina, und Baker Emily R, Hrsg. Medical complications in pregnancy. New York: McGraw-Hill, 2005.

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1933-, Burrow Gerard N., und Ferris Thomas F. 1930-, Hrsg. Medical complications during pregnancy. 4. Aufl. Philadelphia: W.B. Saunders, 1995.

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1933-, Burrow Gerard N., und Duffy Thomas P, Hrsg. Medical complications during pregnancy. 5. Aufl. Philadelphia: W.B. Saunders Co., 1999.

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8

E, Roberts William, Hrsg. Medical complications during pregnancy. Philadelphia: Saunders, 1992.

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S, Yerby Mark, und Devinsky Orrin, Hrsg. Neurologic complications of pregnancy. Philadelphia: Saunders, 1994.

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1933-, Burrow Gerard N., und Ferris Thomas F. 1930-, Hrsg. Medical complications during pregnancy. 3. Aufl. Philadelphia: Saunders, 1988.

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Mehr Quellen

Buchteile zum Thema "Pregnancy Complications":

1

Roy, Deblina. „Pregnancy Complications“. In Encyclopedia of Evolutionary Psychological Science, 1–8. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-16999-6_730-1.

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Roy, Deblina. „Pregnancy Complications“. In Encyclopedia of Evolutionary Psychological Science, 6128–35. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-19650-3_730.

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3

Lefebvre, Cedric W., Jay P. Babich, James H. Grendell, James H. Grendell, John E. Heffner, Ronan Thibault, Claude Pichard et al. „Pregnancy, Infectious Complications“. In Encyclopedia of Intensive Care Medicine, 1803–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_93.

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Mathiesen, Elisabeth R., Lene Ringholm und Peter Damm. „Complications in Pregnancy“. In A Practical Manual of Diabetes in Pregnancy, 257–68. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119043805.ch20.

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Palomba, Stefano, und Bart C. J. M. Fauser. „Complications of Pregnancy“. In Infertility in Women with Polycystic Ovary Syndrome, 305–23. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-45534-1_22.

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Dewey, Kayla, Kathryn Voss und Carolyn Phillips. „Early Pregnancy Complications“. In Emergency Department Management of Obstetric Complications, 1–14. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-54410-6_1.

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Pat, Susan. „Ectopic Pregnancy and Complications of Pregnancy“. In When Doctors Get Sick, 413–17. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2001-0_46.

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Quinlan, Jeffrey D. „Obstetric Complications During Pregnancy“. In Family Medicine, 165–76. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-04414-9_13.

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Davison, John M., Adrian I. Katz und Marshall D. Lindheimer. „Renal Complications of Pregnancy“. In Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS, 561–603. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4757-6632-5_35.

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Smith, Mindy A., und Judith A. Suess. „Obstetric Complications During Pregnancy“. In Family Medicine, 106–21. New York, NY: Springer New York, 1998. http://dx.doi.org/10.1007/978-1-4757-2947-4_13.

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Konferenzberichte zum Thema "Pregnancy Complications":

1

Farah, Huda Mohamed, Muram Elmubarak Elamin, Rahaf Nader Nader Nader, Rana Said Alabsi, Salma Bouazza Bouabidi, Sara Elgaili Khogali Suleiman, Shahd Mohammad Nasr, Shouq Fahad Al-Rumaihi, Zain Zaki Zakaria und Maha alasmakh Alasmakh. „Metagenomic Analysis of Oral Microbiome during pregnancy“. In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0135.

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Pregnancy is a dynamic physiological process associated with significant hormonal, immune and metabolic changes to support the growth and development of the fetus. Several studies have highlighted the role of gut microbiota during pregnancy1. The composition of gut microbiota changes dramatically during the course of pregnancy with an increase in Proteobacteria and Actinobacteria, a decline in butyrate-producing bacteria and a reduction in bacterial richness at the end of pregnancy2. These modifications were anticipated to favour the increased metabolic demand during pregnancy, which will, in turn, support healthy fetal growth3. Gut microbiota has also been suggested to contribute to weight gain during pregnancy via increased absorption of glucose and fatty acids, induction of catabolic pathways, increased fasting-induced adipocyte factor secretion, and stimulation of the immune system2, 4. The oral cavity houses the second most diverse microbiota after the gut harbouring over 700 species of bacteria. Oral microbiota plays a crucial role in maintaining oral homeostasis, protecting the oral cavity and preventing disease development5. Little is known about the role of the oral microbiome during pregnancy. One study examined changes in oral microbiota during pregnancy on Japanese women and found that the total viable microbial counts were higher during pregnancy, as were levels of the pathogenic bacteria Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Candida6. Several studies have also found correlations between oral infections and pregnancy complications, further suggesting mechanisms connecting the oral microbiome with the state of pregnancy7. The Qatari Birth Cohort (QbiC) was successfully developed in July 2018 by Qatar Biobank. It is an epidemiological study that aims to assess the synergetic role of environmental exposure and genetic factors in the development of chronic disease. It monitors the health of women throughout their pregnancy and after birth. The present study is designed to explore changes in the salivary microbiome, using high throughput sequencing during pregnancy and to explore key microbial clades involved in pregnancy.

2

Tagieva, F. A. „On the risk of pregnancy complications“. In General question of world science. "Science of Russia", 2019. http://dx.doi.org/10.18411/gq-31-07-2019-35.

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3

Schmitt, S., T. Meller, F. Stein, K. Brosch, S. Meinert, D. Grotegerd, U. Dannlowski, A. Krug, I. Nenadíc und T. Kirchner. „The impact from complications of pregnancy on gyrification“. In Abstracts of the 2nd Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403026.

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4

Verdezoto, Nervo, Francisca Carpio-Arias, Valeria Carpio-Arias, Nicola Mackintosh, Parisa Eslambolchilar, Verónica Delgado, Catherine Andrade und Galo Vásconez. „Indigenous Women Managing Pregnancy Complications in Rural Ecuador“. In NordiCHI '20: Shaping Experiences, Shaping Society. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3419249.3420141.

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5

Konnaiyan, Karthik Raj, Surya Cheemalapati, Anna Pyayt und Michael Gubanov. „mHealth dipstick analyzer for monitoring of pregnancy complications“. In 2016 IEEE SENSORS. IEEE, 2016. http://dx.doi.org/10.1109/icsens.2016.7808968.

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6

Bartkeviciute, A., und D. Bartkevičienė. „P217 The impact of Ureaplasma infections on pregnancy complications“. In Abstracts for the STI & HIV World Congress, July 14–17 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/sextrans-2021-sti.304.

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7

Marin, Iuliana, und Nicolae Goga. „LEARNING ANALYTICS SOFTWARE FOR MEDICAL STUDENTS REGARDING PREGNANCY COMPLICATIONS“. In 13th International Technology, Education and Development Conference. IATED, 2019. http://dx.doi.org/10.21125/inted.2019.0870.

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8

„Trans-biobank genome-wide association analysis of pregnancy complications“. In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-225.

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Korneeva, Inna, Kristina Kramar, Evgeniia Semenova und Zafar Yuldashev. „A System for Remote Monitoring of Pregnant Women's Health State and Pregnancy Complications Prediction“. In Special Session on Remote Management and Health Monitoring. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0011011500003123.

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„Evaluation of maternal and fetal complications arising from pregnancy trauma“. In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.209.

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Berichte der Organisationen zum Thema "Pregnancy Complications":

1

Brännström, Mats, Ylva Carlsson und Henrik Hagberg. Obstetric outcome after uterus transplantation. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Januar 2023. http://dx.doi.org/10.37766/inplasy2023.1.0052.

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Review question / Objective: Is delivery by elective cesarean section as safe for the mother and the neonate after uterus transplantation as after delivery by elective cesarean section for reasons such as breech and psychological indication regarding stillbirth/neonatal mortality, neonatal morbidity, maternal mortality, and morbidity? Rationale: To compare pregnancy, obstetrical and neonatal complications at delivery by cesarean section in patients that have undergone uterus transplantation and in a normal groups of women.

2

Huntington, Dale. Meeting women's health care needs after abortion. Population Council, 2000. http://dx.doi.org/10.31899/rh2000.1036.

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Women who seek emergency treatment for abortion complications—bleeding, infection, and injuries to the reproductive tract system—should be a priority group for reproductive health care programs. These women often receive poor-quality services that do not address their multiple health needs. They may be discharged without counseling on postoperative recuperation, family planning (FP), or other reproductive health (RH) issues. Women who have had an induced abortion due to an unwanted pregnancy are likely to have a repeat abortion unless they receive appropriate FP counseling and services. Preventing repeat unsafe abortions is important for RH programs because it saves women's lives, protects women’s health, and reduces the need for costly emergency services for abortion complications. At the 1994 International Conference on Population and Development, the world's governments called for improvements in postabortion medical services. As part of the resulting international postabortion care initiative, the Population Council’s Operations Research and Technical Assistance projects worked collaboratively to conduct research on interventions to improve postabortion care. This brief summarizes the major findings of this research and relevant studies by other international organizations.

3

Foreit, James R. Postabortion family planning benefits clients and providers. Population Council, 2005. http://dx.doi.org/10.31899/rh16.1006.

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A woman’s fertility can return quickly following an abortion or miscarriage, yet recent data show high levels of unmet need for family planning (FP) among women who have been treated for incomplete abortion. This leaves many women at risk of another unintended pregnancy and in some cases subsequent repeated abortions and abortion-related complications. It is thus vital for programs to provide a comprehensive package of postabortion care (PAC) services that includes medical treatment, FP counseling and services, and other reproductive health services such as evaluation and treatment for sexually transmitted infections, HIV counseling and/or testing, and community support and mobilization. Providing FP services within PAC benefits clients and programs. Facilities that can effectively treat women with incomplete abortions can also provide contraceptive services, including counseling and appropriate methods. As stated in this brief, any provider who can treat incomplete abortion can also provide selected FP methods. Clients, providers, and programs benefit when FP methods are provided to postabortion clients at the time of treatment.

4

Cao, Xianling, Xuanyou Zhou, Naixin Xu, Songchang Chang und Chenming Xu. Association of IL-4 and IL-10 Polymorphisms with Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0044.

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Review question / Objective: The aim of our systematic review and meta-analysis was to summarize the effects of IL-4 and IL-10 gene polymorphism and clarify their possible association with PTB. Condition being studied: World Health Organization (WHO) defines preterm birth (PTB) as babies born alive before 37 weeks of pregnancy are completed. The new estimates show that the prevalence of PTB during 2014 ranged from 8.7% to13.4% of all live births, about 15 million preterm babies born each year. Besides, PTB is the leading cause of death worldwide for children below 5 years of age. Babies born preterm are at an increased risk of short-term and long-term complications attributed to immaturity of multiple organ systems, such as cerebral palsy, intellectual disabilities, vision and hearing impairments, and impaired cognitive development. PTB has become a worldwide public health problem, but its etiology remains unclear. Accumulating evidence shows that PTB is a syndrome that can be attributed to a variety of pathological processes(5). Inflammatory diseases and genetic background are known risk factors for PTB, many studies had shown that genetic variations in proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1 α (IL-1 α) are associated with increased risk of PTB, but the relationship between genetic polymorphism in anti-inflammatory cytokines and risk of PTB remains controversial.

5

Jamlick, Karumbi. Do emergency obstetric referral interventions reduce maternal and neonatal mortalities in low- and middle-income countries? SUPPORT, 2016. http://dx.doi.org/10.30846/1608123.

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Ensuring access to healthcare by pregnant women is a challenge in low- and middle-income countries. Even if access is possible, a lack of adequate personnel or equipment may mean that complications cannot be treated when they arise. Emergency referral interventions have been advocated to reduce both maternal and neonatal mortality.

6

Feng, Zhichao, Zhimin Yan und Qianyun Liu. MRI Signs for Prenatal Prediction of Placenta Accreta Spectrum Disorders and Invasiveness in High-risk Pregnant Women: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0003.

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Review question / Objective: This meta-analysis aimed to identify the significant MRI signs for placenta accreta spectrum in high-risk pregnant women and to determine their diagnostic value. Condition being studied: Placenta accreta spectrum (PAS) is a dangerous complication in pregnancies with increasing incidence worldwide, in which the villous tissue adheres or invades the uterine wall. Eligibility criteria: Articles assessing the diagnostic performance of MRI signs for PAS and/or placenta percreta in high-risk pregnant women underwent full-text review. Included studies required confirmation of diagnosis based on intraoperative and/or pathologic findings.

7

de Carvalho, Clístenes Crístian, Ioannis Kapsokalyvas und Kariem El-Boghdadly. Second-generation supraglottic airways vs endotracheal tubes in adults undergoing abdominopelvic surgeries: a protocol for a systematic review with pairwise meta-analyses of randomised clinical trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0041.

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Review question / Objective: We aim to compare second-generation supraglottic airways with endotracheal tubes for perioperative safety and quality of postoperative recovery as well as for ventilation performance and risk of pulmonary aspiration. Eligibility criteria: Inclusion criteria will be as follows: randomized clinical trials; human patients aged ≥ 16 years undergoing abdominopelvic procedures under general anaesthesia from any population (e.g., general population, pregnant women, obese patients); data available on any outcome related to insertion performance (e.g., failed first attempt, failed insertion, and time to insertion), ventilation efficacy (e.g., leak pressure, leak fraction, and ventilation inadequacy), risk of regurgitation and aspiration (e.g., gastric insufflation, regurgitation, and aspiration), quality of postoperative recovery (e.g., sore throat, hoarseness, and postoperative nausea and vomiting [PONV]), and major complications (e.g., laryngospasm, bronchospasm, and hypoxemia); and comparison between any second-generation SGA and an endotracheal tube. We will exclude: studies reported in a language that prevent us of extracting relevant information; outcomes with no objective data presented (i.e., effect sizes, measures of dispersion, frequency, etc.); and studies with contradictory data.

8

Donor eggs may be linked to higher risk of pregnancy complications following IVF. National Institute for Health Research, Mai 2016. http://dx.doi.org/10.3310/signal-000243.

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Management of complications, pregnancy, childbirth and the postpartum period in the presence of FGM/C. Population Council, 2007. http://dx.doi.org/10.31899/rh14.1065.

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Antiretroviral treatment for pregnant women living with HIV: A summary of issues, interventions, and evidence. Population Council, 2016. http://dx.doi.org/10.31899/sbsr2016.1013.

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Antiretroviral treatment (ART) for women living with HIV is vital to ensuring safe motherhood and reducing vertical transmission. Each year, as many as 42,000 women living with HIV die of HIV and pregnancy-related complications. While significant progress has been made with 93% of pregnant women in 22 priority countries who have accessed combination ART (or cART, formerly called HAART), not all pregnant women can access treatment. In low- and middle-income countries in particular, treatment access for pregnant women living with HIV has been hampered by availability of medications and standardized treatment eligibility criteria that traditionally prioritized prevention of HIV transmission to the infant over treatment for the health of the woman. This brief summarizes the issues, interventions, and evidence as of 2016.