Thematische Bibliographien / Pre-symptomatic patients

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Auswahl der wissenschaftlichen Literatur zum Thema „Pre-symptomatic patients“

Autor: Grafiati

Veröffentlicht am 30. Juni 2021

Zuletzt aktualisiert am 1. Februar 2022

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Zeitschriftenartikel zum Thema "Pre-symptomatic patients"

Gorospe, J. R., S. Naidu, A. B. Johnson, V. Puri, G. V. Raymond, S. D. Jenkins, R. C. Pedersen et al. „Molecular findings in symptomatic and pre-symptomatic Alexander disease patients“. Neurology 58, Nr. 10 (28.05.2002): 1494–500. http://dx.doi.org/10.1212/wnl.58.10.1494.

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Levina, Marina, und Roswell Quinn. „From symptomatic to pre-symptomatic patient: the tide of personal genomics“. Journal of Science Communication 10, Nr. 03 (21.09.2011): C03. http://dx.doi.org/10.22323/2.10030303.

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Personal Genomics Companies are an emerging form of biotechnology startup that bring rapidly advancing whole genome technologies to a variety of commercial venues. With a combination of direct-to-consumer marketing, social media, and Web 2.0 applications these companies seek to create novel uses, including entertainment, for what is described as predictive medicine – that is the use of genetic marketers to create health forecasts that would allow individual’s healthcare to be tailored to their individual genomic data. In this brief piece, the authors use a critical cultural approach to question how this combination of genomics research, marketing, and communications technologies may alter both patient experiences and research processes. In it we argue these companies radically expand the definition of a patient by claiming all consumers are simply pre-symptomatic patients. Moreover, by placing genomic data on both the marketplace and cyberspace, personal genomic companies seek to create new avenues of research that alter how we define (and access) research agendas and human subjects. Therefore, beyond commonly discussed issues of ethics and privacy rights, Personal Genomics has the potential to alter both healthcare priorities and distribution.

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Salter, Matthew, Ryan Powell, Jennifer Back, Francis Grand, Christina Koutsothanasi, Jayne Green, Ewan Hunter, Aroul Ramadass, Jurjen Westra und Alexandre Akoulitchev. „Genomic architecture differences at the HTT locus underlie symptomatic and pre-symptomatic cases of Huntington’s disease.“ F1000Research 7 (06.11.2018): 1757. http://dx.doi.org/10.12688/f1000research.15828.1.

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Background:Huntington’s disease (HD) is a progressive neurodegenerative condition that causes degeneration of neurons in the brain, ultimately leading to death. The root cause of HD is an expanded trinucleotide cytosine-adenine-guanine (CAG) repeat in the “huntingtin gene” (HTT). While there is a rough correlation between the number of CAG repeats and disease onset, the development of clinical symptoms can vary by decades within individuals and little is known about this pre-symptomatic phase.Methods:Using peripheral blood samples from HD patients and healthy controls we usedEpiSwitch™, a validated high-resolution industrial platform for the detection of chromosome conformations, to assess chromatin architecture in the immediate vicinity of theHTTgene. We evaluated chromatin conformations at 20 sites across 225 kb of theHTTlocus in healthy controls, verified symptomatic HD patients (CAG, n>39) and patients with CAG expansions who had not yet manifested clinical symptoms of HD.Results:Discrete chromosome conformations were observed across the patient groups. We found two constitutive interactions (occurring in all patient groups) and seven conditional interactions which were present in HD, but not in healthy controls. Most important, we observed three conditional interactions that were present only in HD patients manifesting clinical symptoms (symptomatic cases), but not in presymptomatic cases. Of the patients in the symptomatic HD cohort, 86% (6 out of 7) demonstrated at least one of the specific chromosome conformations associated with symptomatic HD.Conclusion:Our results provide the first evidence that chromatin architecture at theHTTlocus is systemically altered in patients with HD, with conditional differences between clinical stages. Given the high clinical need in having a molecular tool to assess disease progression in HD, these results strongly suggest that the non-invasive assessment of chromosome conformation signatures can be a valuable addition to prognostic assessment of HD patients.

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Salter, Matthew, Ryan Powell, Jennifer Back, Francis Grand, Christina Koutsothanasi, Jayne Green, Ewan Hunter, Aroul Ramadass, Jurjen Westra und Alexandre Akoulitchev. „Genomic architecture differences at the HTT locus underlie symptomatic and pre-symptomatic cases of Huntington’s disease.“ F1000Research 7 (26.03.2019): 1757. http://dx.doi.org/10.12688/f1000research.15828.2.

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Leonelli, Fabio M., Roberto De Ponti und Giuseppe Bagliani. „Clinical Approach to Symptomatic and Asymptomatic Patients with Ventricular Pre-excitation“. Cardiac Electrophysiology Clinics 12, Nr. 4 (Dezember 2020): 527–39. http://dx.doi.org/10.1016/j.ccep.2020.08.004.

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Serpino, C., V. Sciruicchio, K. Ricci, F. Giovanni und M. De Tommaso. „44. Features of laser evoked potentials in pre-symptomatic Huntington disease patients“. Clinical Neurophysiology 124, Nr. 11 (November 2013): e199. http://dx.doi.org/10.1016/j.clinph.2013.06.071.

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de Souza, Rainha J., Aaron de Souza und Meera D. Nagvekar. „F-wave studies in diabetes mellitus: A comparison between pre-symptomatic and symptomatic patients with distal sensory polyneuropathy“. Neurology, Psychiatry and Brain Research 30 (Dezember 2018): 125–31. http://dx.doi.org/10.1016/j.npbr.2018.09.002.

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., Rashmi. „A Descriptive Study to Assess the Knowledge regarding Home Based Care of Corona Positive Patients (Mild, Pre-symptomatic) and Quarantined People among the Students of Selected Nursing College, New Delhi“. International Journal of Nursing & Midwifery Research 07, Nr. 03 (16.03.2021): 12–15. http://dx.doi.org/10.24321/2455.9318.202020.

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A descriptive study was conducted to assess the knowledge regarding home based care of corona positive patients (mild, pre symptomatic) and quarantined people among the students of selected nursing college. Objective of the study was to assess the knowledge of students regarding home based care of corona positive patients (mild and pre-symptomatic) and quarantined people. By using non experimental descriptive research design it was conducted among 79 subjects who were studying in DGNM 2nd year and DGNM 3rd year of Rufaida College of Nursing by non probability convenience sampling technique. The tool developed for the data collection was a self structured knowledge questionnaire. The data was analyzed using descriptive statistics. Findings revealed that out of 79 subjects, 84.81% had average knowledge followed by 11.39% having good knowledge, 2.53% having poor knowledge and 1.27% having excellent knowledge regardinghome based care of corona positive patients (mild, pre-symptomatic) and quarantined people.

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McLaughlin, Nancy, und Michel W. Bojanowski. „Aneurysmal Surgery in the Presence of Angiographic Vasospasm: An Outcome Assessment“. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 33, Nr. 2 (Juli 2006): 181–88. http://dx.doi.org/10.1017/s0317167100004947.

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ABSTRACT:Background and Purpose:The timing of aneurysmal surgery for patients presenting within the period at risk for vasospasm (VS) is controversial. The goal of this study is to review our experience of surgically treated patients in the presence of angiographic VS.Materials and Methods:From 1990-2004, 894 consecutive patients presented with an aneurysmal subarachnoid hemorrhage (SAH) and were treated with a policy of early surgery. We retrospectively analyzed the patients that had pre-operative angiographic VS. In this study, symptomatic VS was diagnosed when a decreased level of consciousness and/or focal deficit occurred after SAH in the presence of angiographic VS without confounding factors. Functional outcome was assessed three months after SAH using the Glasgow Outcome Scale.Results:Of the 40 patients studied, 62.5% were in good clinical grade Hunt & Hess (H&H 1-2) on admission; 25%, intermediate grade (H&H 3); 12.5%, poor grade (H&H 4-5). Surgery was performed 24 hours or less after initial angiography in 87.5% of patients and less than 48 hours in 97.5%. Pre-operative symptomatic VS was diagnosed in 25%. Postoperatively, angiographic VS was documented in 87.2%. Of the 30% of patients that presented post-operative symptomatic VS, 66.7% also demonstrated pre-operative symptomatic VS. The functional outcome was favorable in 92.5% of the studied patients. Two deaths occurred in patients presenting pre-operative early radiological and symptomatic VS.Conclusion:Aneurysmal surgery, especially between 3-12 days following SAH, in the presence of asymptomatic pre-operative angiographic VS can be associated with a good outcome. Early surgery is not contra-indicated and might enable optimal treatment of VS.

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Basile, Luca, Víctor Guadalupe-Fernández, Manuel Valdivia Guijarro, Ana Martinez Mateo, Pilar Ciruela Navas und Jacobo Mendioroz Peña. „Diagnostic Performance of Ag-RDTs and NAAT for SARS-CoV2 Identification in Symptomatic Patients in Catalonia“. Viruses 13, Nr. 5 (14.05.2021): 908. http://dx.doi.org/10.3390/v13050908.

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The use of rapid antigenic tests (Ag-RDTs) to diagnose a SARS-CoV-2 infection has become a common practice recently. This study aimed to evaluate performance of Abbott PanbioTM Ag-RDTs with regard to nucleic acid amplification testing (NAAT) in the early stages of the disease. A cohort of 149,026 infected symptomatic patients, reported in Catalonia from November 2020 to January 2021, was selected. The positivity rates of the two tests were compared with respect to the dates of symptom onset. Ag-RDTs presented positivity rates of 84% in the transmission phases of the disease and 31% in the pre-symptomatic period, compared to 93% and 91%, respectively, for NAAT. The detection of many false negatives with Ag-RDTs during the pre-symptomatic period demonstrates the risk of virus dissemination with this diagnostic technique if used outside the symptomatic period.

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Dissertationen zum Thema "Pre-symptomatic patients"

Crossen, Kaylee. „Parent Experiences with Newborn Screening and Medical Management for Late-onset Pompe Disease“. University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623166079821619.

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Bücher zum Thema "Pre-symptomatic patients"

Felquer, Laura Acosta, und Enrique R. Soriano. Approach to management and symptomatic (including non-pharmacologic) management of psoriatic arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0027.

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Psoriatic arthritis (PsA) is a heterogenous disease with multiple manifestations and comorbidities, and requires a collaborative management with other specialists. The major symptoms bordering patients are pain stiffness, and swelling, but fatigue, depression, embarrassment and fear are frequent and not always assessed by treating physicians. Non-steroidal anti-inflammatory drugs and local glucocorticosteroid injections remain important treatment options that should be used, although with caution, in the appropriate patient. Since the pre-biologic era, physical therapy has been part of non-pharmacological treatment in patients with rheumatic disease. Unfortunately there is little evidence of the efficacy of rehabilitation in PsA with no study with high grade of evidence. Surgery should be reserved for advanced cases as the new paradigms in the treatment of PsA (early diagnosis and treatment, remission as an objective, and treat to target), would very probably reduce the already low number of patients that need this last treatment option. In PsA patients surgery outcomes are similar to those of surgical management of other forms of arthritis. Symptomatic and non-pharmacologic management of PsA remain as important adjuvants of PsA treatment, although with little evidence.

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Flinter, Frances. Ethical aspects of genetic testing. Herausgegeben von Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0301_update_001.

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The increasing availability of genetic tests is transforming health care. Patients can benefit from earlier, more precise diagnosis and sometimes tailor-made treatment; their relatives can be offered pre-symptomatic, predictive tests and carrier tests. Physicians must balance confidentiality with duty to other individuals, and are responsible for using genetic tests for the benefit of patients in an ethical way. An offer of testing must balance potential additional benefit from potential downsides of testing including psychological effects, risk of error, continuing uncertainty, and cost. The ability to do multiple tests on many genes, even to sequence the whole genome, is rapidly approaching, and mainstreaming of tests means that geneticists are not necessarily involved. Further work and thinking needs to inform medical ethics in this area.

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Introduction. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199673278.003.0001.

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Using electricity to relieve pain is an age-old technique that pre-dates the discovery of electricity. The ancient Egyptians used electric fish to treat various ailments. Transcutaneous electrical nerve stimulation (TENS) is a technique that delivers pulsed electrical currents across the intact surface of the skin to stimulate peripheral nerves using a ‘standard TENS device’ and conductive electrodes. TENS is principally used as a stand-alone treatment or as an adjunct to core treatment for symptomatic relief of most types of pain. TENS is popular with patients and practitioners because it is non-invasive, easy to administer, and has few side-effects or drug interactions. The purpose of this chapter is to overview what TENS is, why it is used, its history, and terminology used in the TENS literature

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Shahane, Shantanu. Osteoarthritis of the elbow joint. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.005.005.

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♦ Symptomatic, primary osteoarthritis of the elbow usually occurs in young men involved in heavy manual labour.♦ Common causes of secondary osteoarthritis of the elbow are trauma, infection, bleeding disorders and neuropathic conditions.♦ Clinically, the commonest presenting symptom is loss of motion. Patients can also complain of pain, locking and ulnar nerve symptoms.♦ Plain X-rays are usually sufficient for diagnosis. They show reduction in joint space and osteophytes at the tip of olecranon and coronoid processes. Loose bodies are also frequently seen.♦ Symptoms in early stages of arthritis are controlled by nonoperative means. Steroids are rarely used in clinical practice.♦ In advanced cases, numerous operative treatments including arthroscopic and open procedures are available.♦ Total Elbow replacement (TER) for primary degenerative arthritis of the elbow is only to be considered as the last option and when stringent pre and post-operative requirements are followed.

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Buchteile zum Thema "Pre-symptomatic patients"

Haddas, R., A. Satin, D. Mar, I. Lieberman, A. Block, T. Belanger, M. Kayanja und RS Kakar. „The effect of scoliosis support orthosis bracing on adult spinal deformity patients: evaluation of gait and dynamic balance“. In Studies in Health Technology and Informatics. IOS Press, 2021. http://dx.doi.org/10.3233/shti210448.

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Non-operative treatment is regarded as the first-line therapy for patients with adult spinal deformity (ASD) without neurologic deficits or significant impairment. While there is high-level evidence supporting the use of rigid bracing in adolescent idiopathic scoliosis, there is a paucity of literature pertaining to the use of scoliosis support orthosis (SSO) in ASD patients. To investigate the impact of an SSO on pain, gait parameters, and functional balance measures in symptomatic ASD patients. Thirty ASD patients (26 Females, Age: 72.7, Cobb Angle: 47.1°) were evaluated on 3 different occasions: first day of bracing: baseline (Pre), and 45-min post fitting (Post45m), and after 8-weeks of bracing for 4 hours a day (Post8w). Each patient performed a 6-minute walk (over-ground gait), a dynamic balance test, and completed VAS, ODI, and SRS22r. Significant short- and long-term improvements using SSO were found in the 6-minute walk (Pre: 278.6; Post45m: 322.2; Post8w: 338.8 m, p<0.001), walking speed (Pre: 0.88; Post45m: 0.97; Post8w: 0.97 m/s, p<0.001), head total sway distance during the balance test (Pre: 81.33; Post45m: 68.63; Post8w: 60.72 cm, p=0.048), low-back pain (VAS: Pre: 5.5; Post45m: 3.5; Post8w: 3.3, p<0.001), and for the ODI (Pre: 41.9; Post45m: 32.9; Post8w: 30.1, p=0.005).This study demonstrated clinically significant improvements in PROMs, spatiotemporal gait measures, and functional balance measures after continuous use of a SSO. These improvements were observed immediately following brace-fitting and maintained at an 8-week follow-up. Given these results, it is reasonable to consider a SSO for conservative management of patients with mild symptoms of pain and deformity, and who have not yet progressed to meet surgical indications.

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Pappone, Carlo, und Vincenzo Santinelli. „Pre-excitation related to Mahaim physiology“. In ESC CardioMed, 2094–100. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0490.

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Rare accessory pathways, such as Mahaim fibres, have been postulated to result in cardiac pre-excitation. However, most lack the histopathological correlation that has been demonstrated for the Wolff–Parkinson–White pattern. This chapter will discuss the Mahaim fibre tachycardias with left bundle branch block pattern. Mahaim fibres are characterized by the presence of different accessory pathways with decremental conduction (Mahaim physiology, i.e. conduction slows at faster heart rates), which only conducts in an antegrade fashion. The Mahaim fibres have a different anatomical location and distribution that characteristically terminate in the ventricles into or near the conducting system and are responsible for the constellation of electrophysiological features that define Mahaim tachycardias. Similar to other types of pre-excitation syndromes, there are two treatment options available for the treatment of Mahaim fibre tachycardias: pharmacological therapy and/or curative ablation. Catheter ablation offers the greatest chance at definitive therapy for symptomatic patients experiencing frequent Mahaim tachycardias.

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Schmalz, Philip G. R., Raghav Gupta und Christopher S. Ogilvy. „Unruptured Eloquent Arteriovenous Malformation Presenting with Seizure“. In Cerebrovascular Neurosurgery, 203–14. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190887728.003.0022.

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Abstract: Unruptured cerebral arteriovenous malformations often present with seizure. The mechanism of seizure can vary from effect of surrounding hemosiderin from subclinical hemorrhage, arterial steal, or venous congestion. Medical and surgical management should primarily focus on reduction of seizure symptoms and elimination or reduction of arteriovenous malformation rupture risk. Arteriovenous malformation treatment lowers seizure risk, and should be considered for patients in whom resection can be achieved with acceptably low morbidity and mortality. The exact approach chosen will depend on the size, location, and complexity of the arteriovenous malformation. This chapter discusses the pre-surgical evaluation and treatment by surgical resection (with adjunctive embolization) for patients presenting symptomatic with seizures from unruptured cerebral arteriovenous malformations.

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Doolittle, Matthew, und Katherine N. DuHamel. „Posttraumatic Stress Disorder Associated with Cancer Diagnosis and Treatment“. In Psycho-Oncology, herausgegeben von William S. Breitbart, 363–73. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190097653.003.0047.

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Posttraumatic stress disorder (PTSD) is a set of maladaptive responses to intensely fearful or life-threatening events. Unlike other traumas, the trauma of cancer is not generally a single catastrophic event, but is instead an ongoing series of fearful and painful experiences associated with the threat of death. Unlike the DSM-IV, the DSM-5 defines medical trauma in objective terms as an identifiable catastrophic event, and this complicates the applicability of the model to cancer. Nonetheless, maladaptive stress responses can clearly result in increased distress in cancer patients, and in a subset of highly symptomatic people they may interfere with adherence to necessary or even life-saving medical treatments. The heterogeneity of studies and methodologies does not yet allow clear estimation of the prevalence of such responses. However, rates of posttraumatic stress symptoms among patients diagnosed with cancer are consistently higher than those in the general population. Risk factors are not clearly defined in the general population and are less well described in the cancer population, but it is likely that patients with pre-existing psychiatric diagnoses and especially patients with prior trauma are at elevated risk. Diagnosis and treatment of PTSD in the cancer setting are currently analogous to that in the noncancer setting, although research on nonpharmacological interventions is developing, and research on medications is almost nonexistent. For psycho-oncologists, the task is to devise more effective and methodical ways of identifying at-risk or symptomatic populations, and to develop treatments that may improve the quality of life and improve adherence in these vulnerable patients.

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Tamargo, Juan. „Rhythm control: antiarrhythmic drugs“. In ESC CardioMed, 2162–68. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0508.

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Atrial fibrillation (AF) is the most common chronic arrhythmia and a major cause of cardiovascular morbidity and mortality. The rhythm control strategy involves the use of antiarrhythmic drugs (AADs) to (1) facilitate the cardioversion of recent-onset AF (<7 days) to sinus rhythm in symptomatic patients without haemodynamic instability. Pre-treatment with AADs facilitates direct current cardioversion and their use for 1–2 months prevents immediate/early recurrences of AF after direct current cardioversion or catheter ablation; and (2) maintain sinus rhythm and prevent recurrences of AF. AADs reduce rather than eliminate AF recurrences. However, a recurrence is not equivalent to treatment failure if AADs render AF less symptomatic, briefer, and less frequent. A significant reduction in AF burden with an improvement in quality of life represents a therapeutic success for many patients. However, AADs present a limited efficacy and can produce serious adverse effects, mainly proarrhythmia and organ toxicity. Therefore, the benefit/risk ratio of the rhythm control should be carefully considered before starting the treatment, and safety, rather than efficacy, should be the primary guide to the final choice of AADs. Combination of AADs with non-pharmacological strategies and upstream therapies and optimal management of co-morbidities which promote AF should be pursued to reduce AF burden and facilitate maintenance of sinus rhythm.

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Meng Wang, Yu, und Calvin C.P. Pang. „Molecular Genetics of Keratoconus: Clinical Implications“. In Ocular Surface Diseases - Some Current Date on Tear Film Problem and Keratoconic Diagnosis. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.90623.

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Occurrence of keratoconus is pan-ethnic with reported prevalence ranging widely from 1:400 to about 1:8000, higher in Asian than Western populations. Its genetics is complex with undefined pattern of inheritance. Familial traits are also known. More than 50 gene loci and 200 variants are associated with keratoconus, some through association studies with quantitative traits of cornea features including curvature and central thickness. Environmental, behavioral, and epigenetic factors are also involved in the etiology, likely interactively with genetic susceptibility. Regardless of sex and age of disease onset, clinical courses and responses to treatment vary. Keratoconus is a major cause of cornea transplantation and is potentially blinding. Currently collagen cross-linking provides effective treatment although responses from some patients can be unpredictable with complications. Early diagnosis is vital to obtain good treatment outcome, but in many patients early signs and symptoms are not obvious. While there are potential biomarkers, reliable pre-symptomatic detection and prediction of treatment response may require multitude of gene variants, cornea properties, and external risk factors.

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Fischer-Rasokat, Ulrich, und Christian Hamm. „Clinical symptoms of stable ischaemic heart disease“. In ESC CardioMed, herausgegeben von William Wijns, 1339–43. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0330.

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Ischaemic heart disease (IHD) becomes symptomatic when myocardial demand exceeds blood supply. Myocardial ischaemia leads to a wide range of symptoms, including chest pain as well as diffuse, worrisome sensations, all of which can be summarized under the term ‘chest discomfort’. Cardiac chest discomfort may be characterized according to four attributes: character, location, duration, and association with provoking or relieving factors. Typical angina pectoris, with a very high probability of significant epicardial coronary stenosis, can be diagnosed if three pre-specified criteria are met, whereas atypical angina pectoris, with only a moderate probability of IHD, and non-anginal chest pain fulfil fewer of these criteria. Angina pectoris can be quantified according to the Canadian Cardiovascular Society classification, which is based on threshold activities of angina-limited physical exertion. Some patients with IHD do not complain of chest discomfort but report symptoms such as sweating, nausea, or dyspnoea that have been demonstrated to be early indicators of IHD, denoted here as ‘angina equivalents’. Patients who do not experience any symptoms at all although myocardial ischaemia is detected are said to have ‘silent’ ischaemia. Patients with chest pain or discomfort use certain uniform hand gestures to describe the localization and character of the pain; thus, body language may be complementary to diagnostic criteria for IHD. Women are more likely to present with atypical forms of chest discomfort, and IHD is diagnosed roughly 10 years later in women than in men. Careful interpretation of patients’ descriptions of their symptoms is crucial to correctly diagnosing IHD.

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Knight, Charles, und Saidi A. Mohiddin. „Alcohol septal ablation for obstructive hypertrophic cardiomyopathy“. In Oxford Textbook of Interventional Cardiology, 683–98. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199569083.003.041.

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Hypertrophic cardiomyopathy (HCM) is a genetic disease occurring in approximately one in 500–1000 of the general population. HCM is often undiagnosed or misdiagnosed, and asymptomatic cases are often unrecognized. Asymmetric left ventricular (LV) hypertrophy (LVH) most often develops during the period of rapid body growth of adolescence, but it may be present in childhood or, rarely, before birth. Progressive LVH after age 20 is uncommon, but initial diagnosis even in old age is not. The hypertrophy predominantly involves the LV, and is often more marked than in any other cardiac disease. Hypertrophy may involve the right ventricle (RV), and an atrial myopathy may be progressive (left atrial enlargement [LA) and increased risks of atrial fibrillation [AF]). RV and LA involvement may be secondary to the LV disease, and/or a primary consequence of the basic molecular defect. The LVH represents hypertrophy and hyperplasia of several cell types, including cardiac myocytes, fibroblasts, and smooth muscle cells, along with excessive collagen and matrix deposition, and abnormalities of the microvasculature. The normal parallel arrangement of myocytes is often disturbed (fibre disarray). Clinical practice addresses three needs: 1) assessing and treating the symptomatic patient; 2) assessing and addressing prognostic risks; and 3) genetic counselling, family screening, and mutation detection (genetic testing). Symptoms due to HCM will often have a striking variation in severity when patients may describe good and bad days, exacerbation of symptoms following large meals and an intolerance of dehydration or a hot climate. Chest pain, with a quality similar to angina pectoris but often developing at rest, dyspnoea, palpitations, dizziness, pre/syncope, and fatigue are the common complaints. Although the relief of LV outflow obstruction (LVOTO) by alcohol septal ablation (ASA) for the management of symptomatic HCM is the focus of this chapter, we will first describe some of the more important features of HCM in order that this procedure can be placed in the context of a complex cardiac condition.

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Aggarwal, Arun. „The Role of the Statistical Method of Motor Unit Number Estimation (MUNE) to Assess the Potential Therapeutic Benefits of Riluzole on Patients with Pre-symptomatic Familial Amyotrophic Lateral Sclerosis“. In Current Advances in Amyotrophic Lateral Sclerosis. InTech, 2013. http://dx.doi.org/10.5772/56559.

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Kakulapati, Vijayalakshmi, Devara Vasumathi, Mahender Reddy S und B. S. S. Deepthi. „Fuzzy-Based Predictive Analytics for Early Detection of Diabetes“. In Pre-Screening Systems for Early Disease Prediction, Detection, and Prevention, 219–47. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7131-5.ch008.

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Today, diabetes is the most costly and burdensome chronic disease. The severity of diabetes is reducing with anticipation, premature recognition, and the early supervision impediments in people. These symptoms are the optimization of the diagnosis phase of the disease through the process of evaluating symptomatic characteristics and daily habits of patients. Big data analytical tools play a useful task in executing significant real-time investigation on the huge volumes of data and are also used to foresee the crisis situations earlier than it occurs. This chapter accomplished an efficient assessment of the applications of machine learning algorithms and tools in the diabetes investigation relating to genetic background and environment. With improving accuracy for early detection and prevention of diabetes, this chapter implemented a fuzzy linear and logistic regression model with fuzzy clustering for predicting early detection of diabetes.

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