Zeitschriftenartikel: „PMAD“

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Dorfman, R., und B. Z. Shilo. „Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region“. Development 128, Nr. 6 (15.03.2001): 965–72. http://dx.doi.org/10.1242/dev.128.6.965.

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The BMP pathway patterns the dorsal region of the Drosophila embryo. Using an antibody recognizing phosphorylated Mad (pMad), we followed signaling directly. In wild-type embryos, a biphasic activation pattern is observed. At the cellular blastoderm stage high pMad levels are detected only in the dorsal-most cell rows that give rise to amnioserosa. This accumulation of pMad requires the ligand Screw (Scw), the Short gastrulation (Sog) protein, and cleavage of their complex by Tolloid (Tld). When the inhibitory activity of Sog is removed, Mad phosphorylation is expanded. In spite of the uniform expression of Scw, pMad expansion is restricted to the dorsal domain of the embryo where Dpp is expressed. This demonstrates that Mad phosphorylation requires simultaneous activation by Scw and Dpp. Indeed, the early pMad pattern is abolished when either the Scw receptor Saxophone (Sax), the Dpp receptor Thickveins (Tkv), or Dpp are removed. After germ band extension, a uniform accumulation of pMad is observed in the entire dorsal domain of the embryo, with a sharp border at the junction with the neuroectoderm. From this stage onward, activation by Scw is no longer required, and Dpp suffices to induce high levels of pMad. In these subsequent phases pMad accumulates normally in the presence of ectopic Sog, in contrast to the early phase, indicating that Sog is only capable of blocking activation by Scw and not by Dpp.

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Puspitasari, Ajeng J., Dagoberto Heredia, Elise Weber, Hannah K. Betcher, Brandon J. Coombes, Ellen M. Brodrick, Susan M. Skinner et al. „Perinatal Mood and Anxiety Disorder Management in Multicenter Community Practices: Clinicians’ Training, Current Practices and Perceived Strategies to Improve Future Implementation“. Journal of Primary Care & Community Health 12 (Januar 2021): 215013272199688. http://dx.doi.org/10.1177/2150132721996888.

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Background: This study aimed to explore clinicians’ perspectives on the current practice of perinatal mood and anxiety disorder (PMAD) management and strategies to improve future implementation. Methods: This study had a cross-sectional, descriptive design. A 35-item electronic survey was sent to clinicians (N = 118) who treated perinatal women and practiced at several community clinics at an academic medical center in the United States. Results: Among clinicians who provided care for perinatal women, 34.7% reported never receiving PMAD management training and 66.3% had less than 10 years of experience. Out of 10 patients who reported psychiatric symptoms, 47.8% of clinicians on average reported providing PMAD management to 1 to 3 patients and 40.7% noted that they conducted screening only when patient expresses PMAD symptoms. Suggested future improvements were providing training, developing a referral list, and establishing integrated behavioral health services. Conclusions: Results from this study indicated that while PMAD screening and management was implemented, improvements are warranted to meet established guidelines. Additionally, clinicians endorsed providing PMAD management to a small percentage of perinatal patients. Suggested strategies to increase adoption and implementation of PMAD management should be explored to improve access to behavioral health services for perinatal women.

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Nguyen, Tho Huu, Tae Hee Han, Stuart J. Newfeld und Mihaela Serpe. „Selective Disruption of Synaptic BMP Signaling by a Smad Mutation Adjacent to the Highly Conserved H2 Helix“. Genetics 216, Nr. 1 (31.07.2020): 159–75. http://dx.doi.org/10.1534/genetics.120.303484.

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Bone morphogenetic proteins (BMPs) shape normal development and function via canonical and noncanonical signaling pathways. BMPs initiate canonical signaling by binding to transmembrane receptors that phosphorylate Smad proteins and induce their translocation into the nucleus and regulation of target genes. Phosphorylated Smads also accumulate at cellular junctions, but this noncanonical, local BMP signaling modality remains less defined. We have recently reported that phosphorylated Smad (pMad in Drosophila) accumulates at synaptic junctions in protein complexes with genetically distinct composition and regulation. Here, we examined a wide collection of Drosophila Mad alleles and searched for molecular features relevant to pMad accumulation at synaptic junctions. We found that strong Mad alleles generally disrupt both synaptic and nuclear pMad, whereas moderate Mad alleles have a wider range of phenotypes and can selectively impact different BMP signaling pathways. Interestingly, regulatory Mad mutations reveal that synaptic pMad appears to be more sensitive to a net reduction in Mad levels than nuclear pMad. Importantly, a previously uncharacterized allele, Mad8, showed markedly reduced synaptic pMad but only moderately diminished nuclear pMad. The postsynaptic composition and electrophysiological properties of Mad8 neuromuscular junctions (NMJs) were also altered. Using biochemical approaches, we examined how a single point mutation in Mad8 could influence the Mad-receptor interface and identified a key motif, the H2 helix. Our study highlights the biological relevance of Smad-dependent, synaptic BMP signaling and uncovers a highly conserved structural feature of Smads, critical for normal development and function.

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Dolezal, Darin, Zhiyan Liu, Qingxiang Zhou und Francesca Pignoni. „Fly LMBR1/LIMR-type protein Lilipod promotes germ-line stem cell self-renewal by enhancing BMP signaling“. Proceedings of the National Academy of Sciences 112, Nr. 45 (28.10.2015): 13928–33. http://dx.doi.org/10.1073/pnas.1509856112.

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Limb development membrane protein-1 (LMBR1)/lipocalin-interacting membrane receptor (LIMR)-type proteins are putative nine-transmembrane receptors that are evolutionarily conserved across metazoans. However, their biological function is unknown. Here, we show that the fly family member Lilipod (Lili) is required for germ-line stem cell (GSC) self-renewal in the Drosophila ovary where it enhances bone morphogenetic protein (BMP) signaling. lili mutant GSCs are lost through differentiation, and display reduced levels of the Dpp transducer pMad and precocious activation of the master differentiation factor bam. Conversely, overexpressed Lili induces supernumerary pMad-positive bamP-GFP–negative GSCs. Interestingly, differentiation of lili mutant GSCs is bam-dependent; however, its effect on pMad is not. Thus, although it promotes stem cell self-renewal by repressing a bam-dependent process, Lilipod enhances transduction of the Dpp signal independently of its suppression of differentiation. In addition, because Lili is still required by a ligand-independent BMP receptor, its function likely occurs between receptor activation and pMad phosphorylation within the signaling cascade. This first, to our knowledge, in vivo characterization of a LMBR1/LIMR-type protein in a genetic model reveals an important role in modulating BMP signaling during the asymmetric division of an adult stem cell population and in other BMP signaling contexts.

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Sardi, Justin, Muhammed Burak Bener, Taylor Simao, Abigail E. Descoteaux, Boris M. Slepchenko und Mayu Inaba. „Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division“. Proceedings of the National Academy of Sciences 118, Nr. 13 (22.03.2021): e2006786118. http://dx.doi.org/10.1073/pnas.2006786118.

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Stem cells divide asymmetrically to generate a stem cell and a differentiating daughter cell. Yet, it remains poorly understood how a stem cell and a differentiating daughter cell can receive distinct levels of niche signal and thus acquire different cell fates (self-renewal versus differentiation), despite being adjacent to each other and thus seemingly exposed to similar levels of niche signaling. In theDrosophilaovary, germline stem cells (GSCs) are maintained by short range bone morphogenetic protein (BMP) signaling; the BMP ligands activate a receptor that phosphorylates the downstream molecule mothers against decapentaplegic (Mad). Phosphorylated Mad (pMad) accumulates in the GSC nucleus and activates the stem cell transcription program. Here, we demonstrate that pMad is highly concentrated in the nucleus of the GSC, while it quickly decreases in the nucleus of the differentiating daughter cell, the precystoblast (preCB), before the completion of cytokinesis. We show that a known Mad phosphatase, Dullard (Dd), is required for the asymmetric partitioning of pMad. Our mathematical modeling recapitulates the high sensitivity of the ratio of pMad levels to the Mad phosphatase activity and explains how the asymmetry arises in a shared cytoplasm. Together, these studies reveal a mechanism for breaking the symmetry of daughter cells during asymmetric stem cell division.

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Wu, Qi, Shaohua Gou, Jinglun Huang, Guijuan Fan, Shiwei Li und Mengyu Liu. „Hyper-branched structure—an active carrier for copolymer with surface activity, anti-polyelectrolyte effect and hydrophobic association in enhanced oil recovery“. RSC Advances 9, Nr. 29 (2019): 16406–17. http://dx.doi.org/10.1039/c9ra01554j.

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Herein, a hyper-branched polymer h-PMAD with, simultaneously, surface activity, an anti-polyelectrolyte effect and a hydrophobic association was prepared via aqueous solution free radical polymerization, and characterized by IR, NMR, TG–DTG and SEM.

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Hutchens, Bridget F., und Frances E. Likis. „A mental health acronym that must be stopped: PMAD“. Archives of Women's Mental Health 22, Nr. 5 (26.11.2018): 709. http://dx.doi.org/10.1007/s00737-018-0932-0.

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Erdonmez, D., S. Mosayyebi, K. Erkan, K. Salimi, N. Nagizade, N. Saglam und Z. M. O. Rzayev. „Nanofabrication and characterization of PVA–organofiller/Ag nanocoatings on pMAD plasmids“. Applied Surface Science 318 (November 2014): 127–31. http://dx.doi.org/10.1016/j.apsusc.2014.02.007.

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Arnaud, Maryvonne, Arnaud Chastanet und Michel DÃ¯Â¿Â½barbouillÃ¯Â¿Â½. „New Vector for Efficient Allelic Replacement in Naturally Nontransformable, Low-GC-Content, Gram-Positive Bacteria“. Applied and Environmental Microbiology 70, Nr. 11 (November 2004): 6887–91. http://dx.doi.org/10.1128/aem.70.11.6887-6891.2004.

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ABSTRACT A shuttle vector designated pMAD was constructed for quickly generating gene inactivation mutants in naturally nontransformable gram-positive bacteria. This vector allows, on X-Gal (5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside) plates, a quick colorimetric blue-white discrimination of bacteria which have lost the plasmid, greatly facilitating clone identification during mutagenesis. The plasmid was used in Staphylococcus aureus, Listeria monocytogenes, and Bacillus cereus to efficiently construct mutants with or without an associated antibiotic resistance gene.

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Bowen, A. „World maternal mental health day“. European Psychiatry 41, S1 (April 2017): s900. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1838.

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IntroductionAs many as 20% of mothers experiences some type of perinatal mood and anxiety disorder (PMAD) worldwide. Women of every culture, age, income level, and race are at risk for PMADs with potential effects to mother and child.ObjectivesTo promote awareness of maternal mental health and PMADs.MethodAn international task force met via online videoconference to make plans for the inaugural World Maternal Mental Health Day. The task force soon grew to include representatives from around the globe with a common goal to increase awareness of and influence policy about maternal mental health. This presentation will discuss the process, successes, challenges, and engage participants in future social marketing strategies for World Maternal Mental Health Day. International reach and impact will be discussed.ResultOrganizations from 12 countries were involved in this event, with twitter and landing page activity across the globe. A unique logo was developed and numerous organizations endorsed the event. An international social media campaign included a Twitter Feed “#Maternal Mental Health Matters” starting in Australia, Facebook page, and landing page. The first World MMH Day was held May 4, 2016.ConclusionIncreased awareness will continue to drive social change with a goal of improving the quality of care for women worldwide who experience all types of PMADs and to reduce the stigma of maternal mental illness. World Maternal Mental Health Day will be held each year on the first Wednesday of May, close to “mother's day” and “mental health week” in many countries.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

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Harris, S., K. S. Rudnicki und J. E. Haber. „Gene conversions and crossing over during homologous and homeologous ectopic recombination in Saccharomyces cerevisiae.“ Genetics 135, Nr. 1 (01.09.1993): 5–16. http://dx.doi.org/10.1093/genetics/135.1.5.

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Abstract The pma1-105 mutation reduces the activity of the yeast plasma membrane H(+)-ATPase and causes cells to be both low pH and ammonium ion sensitive and resistant to the antibiotic hygromycin B. Revertants that can grow at pH 3.0 and on ammonium-containing plates frequently arise by ectopic recombination between pma1-105 and PMA2, a diverged gene that shares 85% DNA sequence identity with PMA1. The gene conversion tracts of revertants of pma1-105 were determined by DNA sequencing the hybrid PMA1::PMA2 genes. Gene conversion tracts ranged from 18-774 bp. The boundaries of these replacements were short (3-26 bp) regions of sequences that were identical between PMA1 and PMA2. These boundaries were not located at the regions of greatest shared identity between the two PMA genes. Similar results were obtained among low pH-resistant revertants of another mutation, pma1-147. One gene conversion was obtained in which the resulting PMA1::PMA2 hybrid was low pH-resistant but still hygromycin B-resistant. This partially active gene differs from a wild-type revertant only by the presence of two PMA2-encoded amino acid substitutions. Thus, some regions of PMA2 are not fully interchangeable with PMA1. We have also compared the efficiency of recombination between pma1-105 and either homeologous PMA2 sequence or homologous PMA1 donor sequences inserted at the same location. PMA2 x pma1-105 recombination occurred at a rate approximately 75-fold less than PMA1 x pma1-105 events. The difference in homology between the interacting sequences did not affect the proportion of gene conversion events associated with a cross-over, as in both cases approximately 5% of the Pma+ recombinants had undergone reciprocal translocations between the two chromosomes carrying pma1-105 and the donor PMA sequences. Reciprocal translocations were identified by a simple and generally useful nutritional test.

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Wittenberg, George F., Lorie G. Richards, Lauren M. Jones-Lush, Steven R. Roys, Rao P. Gullapalli, Suzy Yang, Peter D. Guarino und Albert C. Lo. „Predictors and brain connectivity changes associated with arm motor function improvement from intensive robotic practice in chronic stroke“. F1000Research 5 (31.08.2016): 2119. http://dx.doi.org/10.12688/f1000research.8603.1.

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Background and Purpose: The brain changes that underlie therapy-induced improvement in motor function after stroke remain obscure. This study sought to demonstrate the feasibility and utility of measuring motor system physiology in a clinical trial of intensive upper extremity rehabilitation in chronic stroke-related hemiparesis. Methods: This was a substudy of two multi-center clinical trials of intensive robotic arm therapy in chronic, significantly hemiparetic, stroke patients. Transcranial magnetic stimulation was used to measure motor cortical output to the biceps and extensor digitorum communus muscles. Magnetic resonance imaging (MRI) was used to determine the cortical anatomy, as well as to measure fractional anisotropy, and blood oxygenation (BOLD) during an eyes-closed rest state. Region-of-interest time-series correlation analysis was performed on the BOLD signal to determine interregional connectivity. Functional status was measured with the upper extremity Fugl-Meyer and Wolf Motor Function Test. Results: Motor evoked potential (MEP) presence was associated with better functional outcomes, but the effect was not significant when considering baseline impairment. Affected side internal capsule fractional anisotropy was associated with better function at baseline. Affected side primary motor cortex (M1) activity became more correlated with other frontal motor regions after treatment. Resting state connectivity between affected hemisphere M1 and dorsal premotor area (PMAd) predicted recovery. Conclusions: Presence of motor evoked potentials in the affected motor cortex and its functional connectivity with PMAd may be useful in predicting recovery. Functional connectivity in the motor network shows a trends towards increasing after intensive robotic or non-robotic arm therapy. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifiers: CT00372411 & NCT00333983.

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Wittenberg, George F., Lorie G. Richards, Lauren M. Jones-Lush, Steven R. Roys, Rao P. Gullapalli, Suzy Yang, Peter D. Guarino und Albert C. Lo. „Predictors and brain connectivity changes associated with arm motor function improvement from intensive practice in chronic stroke“. F1000Research 5 (28.02.2017): 2119. http://dx.doi.org/10.12688/f1000research.8603.2.

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Background and Purpose: The brain changes that underlie therapy-induced improvement in motor function after stroke remain obscure. This study sought to demonstrate the feasibility and utility of measuring motor system physiology in a clinical trial of intensive upper extremity rehabilitation in chronic stroke-related hemiparesis. Methods: This was a substudy of two multi-center clinical trials of intensive robotic and intensive conventional therapy arm therapy in chronic, significantly hemiparetic, stroke patients. Transcranial magnetic stimulation was used to measure motor cortical output to the biceps and extensor digitorum communus muscles. Magnetic resonance imaging (MRI) was used to determine the cortical anatomy, as well as to measure fractional anisotropy, and blood oxygenation (BOLD) during an eyes-closed rest state. Region-of-interest time-series correlation analysis was performed on the BOLD signal to determine interregional connectivity. Functional status was measured with the upper extremity Fugl-Meyer and Wolf Motor Function Test. Results: Motor evoked potential (MEP) presence was associated with better functional outcomes, but the effect was not significant when considering baseline impairment. Affected side internal capsule fractional anisotropy was associated with better function at baseline. Affected side primary motor cortex (M1) activity became more correlated with other frontal motor regions after treatment. Resting state connectivity between affected hemisphere M1 and dorsal premotor area (PMAd) predicted recovery. Conclusions: Presence of motor evoked potentials in the affected motor cortex and its functional connectivity with PMAd may be useful in predicting recovery. Functional connectivity in the motor network shows a trends towards increasing after intensive robotic or non-robotic arm therapy. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00372411 \& NCT00333983.

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Supply, P., A. de Kerchove d'Exaerde, T. Roganti, A. Goffeau und F. Foury. „In-frame recombination between the yeast H(+)-ATPase isogenes PMA1 and PMA2: insights into the mechanism of recombination initiated by a double-strand break.“ Molecular and Cellular Biology 15, Nr. 10 (Oktober 1995): 5389–95. http://dx.doi.org/10.1128/mcb.15.10.5389.

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Chimeric PMA1::PMA2 sequences, placed under the control of the PMA1 promoter, were constructed by in vivo recombination between a gapped linearized plasmid containing the PMA2 gene and four different fragments of the PMA1 gene. Correct in-frame assembly of the PMA sequences was screened by the expression of the lacZ reporter gene fused to the PMA2 coding region. Restriction and sequencing analysis of 35 chimeras showed that in all cases, the hybrid sequences was obtained as fusions between continuous sequences specific to PMA1 and PMA2, separated by a region of identity. In all but three cases, the junction sequences were not located at regions of greatest identity. Strikingly, depending on the PMA1 fragment used, junction distribution fell into two categories. In the first, the junctions were scattered over several hundreds of nucleotides upstream of the extremity of the PMA1 fragment, while in the second, they were concentrated at this extremity. Analysis of the alignment of the PMA1 and PMA2 sequences suggests that the distribution is not related to the size of the region of identity at the PMA1-PMA2 boundary but depends on the degree of identity of the PMA genes upstream of the region of identity, the accumulation of successive mismatches leading to a clustered distribution of the junctions. Moreover, the introduction of seven closely spaced mismatches near the end of a PMA1 segment with an otherwise-high level of identity with PMA2 led to a significantly increased concentration of the junctions near this end. These data show that a low level of identity in the vicinity of the common boundary stretch is a strong barrier to recombination. In contrast, consecutive mismatches or regions of overall moderate identity which are located several hundreds of nucleotides upstream from the PMA1 end do not necessarily block recombination.

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YIN, HONGWEI, XIAOYONG XIAO, XIAOQING WEN und TIANSHOU ZHOU. „STABILITY OF REGULATORY PROTEIN GRADIENTS INDUCED BY MORPHOGEN DPP IN DROSOPHILA WING DISC“. International Journal of Bifurcation and Chaos 23, Nr. 08 (August 2013): 1350138. http://dx.doi.org/10.1142/s0218127413501381.

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In the development of Drosophila wing disc, morphogen Dpp, which is a signaling molecule from a local region and disperses into anterior and posterior compartments, builds up a gradient with precise pattern information. Experiments have demonstrated that the key genes (brk, dad, omb and sal) and phosphorylated protein (pMad), which are activated by Dpp signaling molecules and form the gradients of the corresponding proteins of these genes, direct and control the spatial pattern of the wing disc. However, the regulatory network of these genes are in complex and nonlinear interaction with upstream regulators and downstream targets. In this paper, the mathematical model is built according to the regulatory relationships of these key genes. The stabilities of the gradients of these corresponding proteins are investigated. Furthermore, numerical simulations show that these gradients are robust with respect to some major reaction rates in this regulatory network.

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Nakatani, Shingo, Takaaki Hato, Yoko Minamoto und Shigeru Fujita. „Differential Inhibition of Fibrinogen Binding to Agonist-and RGDS Peptide-activated States of GPIIb-IIIa by an anti-GPIIIa Monoclonal Antibody, PMA5“. Thrombosis and Haemostasis 76, Nr. 06 (1996): 1030–37. http://dx.doi.org/10.1055/s-0038-1650703.

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SummaryPlatelet agonists and RGD-containing peptides can convert platelet membrane glycoprotein (GP) Ilb-IIIa from its resting state to an activated state competent to bind soluble fibrinogen. We examined the effects of two anti-GPIIb-IIIa monoclonal antibodies, PMA1 and PMA5, on fibrinogen binding to agonist- and RGD-activated GPIIb-IIIa. PMA1 abolished aggregation of both agonist- and RGDS peptide-activated fixed platelets, and inhibited the binding of 125I-fibrinogen to these platelets almost completely. PMA5 had the same effects on agonist-activated platelets, but had little effect on the aggregation of RGDS-activated fixed platelets, and inhibited fibrinogen binding to RGDS-activated fixed platelets by only 44%. PMA5 bound to agonist- and RGDS-activated platelets equally. Immunoblot analysis showed that PMA5 bound to intact GPIIIa, but not to a 66 kDa fragment of GPIIIa digested by chymotrypsin. Although PMA5 inhibited platelet adhesion to immobilized fibrinogen by 94%, 44% of the remaining adherent platelets were spread. In contrast, no platelet spreading was observed in the presence of PMA1. These findings indicate that PMA5 is a novel anti-GPIIIa monoclonal antibody with the ability to inhibit fibrinogen binding to agonist- and RGD-activated states of GPIIb-IIIa differentially, and suggest that binding of immobilized fibrinogen to RGD-activated GPIIb-IIIa is necessary for platelet spreading.

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Venkata, Ramalingayya Grandhi, Jayaprakash Tadiparthi, Narender Ganuga, Pradeep Jayarajan und Ramakrishna Nirogi. „[P2-082]: SUVN-502 (A PURE 5-HT6 ANTAGONIST): PROMISING THERAPEUTIC POTENTIAL FOR PMAD (POST-MENOPAUSE-ASSOCIATED DEMENTIA) AND SMAD (SURGICAL MENOPAUSE-ASSOCIATED DEMENTIA)“. Alzheimer's & Dementia 13, Nr. 7S_Part_13 (Juli 2017): P637. http://dx.doi.org/10.1016/j.jalz.2017.06.731.

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Coledam, Diogo Henrique Constantino, Douglas dos Santos und Júlio Wilson dos Santos. „Avaliação da potência anaeróbia antes e após o período competitivo em atletas profissionais de futebol“. Conexões 8, Nr. 2 (23.07.2010): 93–102. http://dx.doi.org/10.20396/conex.v8i2.8637743.

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O objetivo deste estudo foi avaliar a potência anaeróbia antes e após o período competitivo em atletas profissionais de futebol. Participaram do estudo 25 atletas do gênero masculino avaliados antes e após o período competitivo. A potência anaeróbia foi avaliada através do teste de corridas de velocidade repetidas (RAST), com o qual foram determinadas a potência máxima (PMAX), potência média (PMED), potência mínima (PMIN) e o índice de fadiga (IF). O teste foi realizado na primeira (PRE) e na ultima (POS) sessão de treinamento do período competitivo, que teve a duração de 20 semanas. Não houve diferença significativa (p>0,05) entre PRE e POS em nenhum dos parâmetros analisados, PMAX (10,70 ± 0,95 vs 10,83 ± 0,87), PMIN (8,48 ± 0,92 vs 8,28 ± 0,76), PMED (9,52 ± 0,83 vs 9,41 ± 0,61) e IF (22,73 ± 7,48 vs 25,53 ± 8,79). Não há alteração significativa na potência anaeróbia após um período competitivo de 20 semanas em atletas profissionais de futebol.

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Bae, Dongryeoul, Keun Seok Seo, Ting Zhang und Chinling Wang. „Characterization of a Potential Listeria monocytogenes Virulence Factor Associated with Attachment to Fresh Produce“. Applied and Environmental Microbiology 79, Nr. 22 (23.08.2013): 6855–61. http://dx.doi.org/10.1128/aem.01006-13.

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ABSTRACTA study to determine the attachment ofL. monocytogenesserotype 4b strain F2365 on vegetables and fruits was conducted. In an initial study, we screened 32 genes encoding surface proteins and lipases of the strain to find highly expressed genes on lettuce leaves. The results showed that transcription levels of LMOf2365_0413, LMOf2365_0498, LMOf2365_0859, LMOf2365_2052, and LMOf2365_2812 were significantly upregulated on lettuce leaves.In silicoanalysis showed that LMOf2365_0859 contains a putative cellulose binding domain. Thus, we hypothesized that this gene may be involved in an attachment to vegetables, and named itlcp(gene encodingListeriacellulose binding protein [LCP]).lcpmutant (Δlcp) andlcpcomplement (F2365::pMAD::cat::lcp) strains were generated by homologous recombination. The abilities of a wild-type (WT) strain, the Δlcpstrain, and the complemented strain to attach to lettuce leaves were evaluated, which indicated that the attachment of the Δlcpstrain to lettuce was significantly less than that of the WT and the complemented strains. Similar results were observed for baby spinach and cantaloupe. Fluorescence microscopy and field emission scanning microscopy analysis further supported these findings. The binding ofL. monocytogenesto cellulose was determined using cellulose acetate-coated plates. The results showed that a binding ability of the Δlcpstrain was significantly lower than that of the wild type. Combined, these results strongly suggest that LCP plays an important role in an attachment to vegetables and fruits.

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Ghislain, M., und A. Goffeau. „The pma1 and pma2 H(+)-ATPases from Schizosaccharomyces pombe are functionally interchangeable.“ Journal of Biological Chemistry 266, Nr. 27 (September 1991): 18276–79. http://dx.doi.org/10.1016/s0021-9258(18)55265-0.

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Hato, T., M. Sumida, M. Yasukawa, A. Watanabe, H. Okuda und Y. Kobayashi. „Induction of platelet Ca2+ influx and mobilization by a monoclonal antibody to CD9 antigen“. Blood 75, Nr. 5 (01.03.1990): 1087–91. http://dx.doi.org/10.1182/blood.v75.5.1087.1087.

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Abstract We found that a monoclonal antibody (MoAb) to CD9 antigen, PMA2, induced a rise in cytosolic free calcium concentration ([Ca2+]i) in fura-2-loaded platelets, and we examined whether this response was due to direct action of PMA2 on CD9 antigen. The rise in [Ca2+]i was dependent on the PMA2 concentration, irrespective of the presence or absence of extracellular Ca2+. The role of secreted adenosine diphosphate (ADP) and thromboxane in the [Ca2+]i response to PMA2 was studied using creatine phosphate/creatine phosphokinase (CP/CPK) and aspirin. Combined treatment with CP/CPK and aspirin abolished the rise in [Ca2+]i, although either CP/CPK or aspirin alone produced only partial inhibition. Inhibition of adenosine triphosphate (ATP) secretion and thromboxane B2 synthesis by an MoAb to the glycoprotein IIb-IIIa complex, PMA1, resulted in little [Ca2+]i response to PMA2. In contrast, thrombasthenic platelets, in which ATP secretion and thromboxane B2 synthesis were normal, showed a normal [Ca2+]i response. When PMA2 was added to CD9+ mononuclear cells, no rise in [Ca2+]i was observed. Thus, we conclude that binding of monoclonal immunoglobulin G molecules to the CD9 antigen raises [Ca2+]i through the effect of secreted ADP and thromboxane on platelets, and that CD9 antigen is not directly involved in induction of Ca2+ influx and mobilization.

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Hato, T., M. Sumida, M. Yasukawa, A. Watanabe, H. Okuda und Y. Kobayashi. „Induction of platelet Ca2+ influx and mobilization by a monoclonal antibody to CD9 antigen“. Blood 75, Nr. 5 (01.03.1990): 1087–91. http://dx.doi.org/10.1182/blood.v75.5.1087.bloodjournal7551087.

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We found that a monoclonal antibody (MoAb) to CD9 antigen, PMA2, induced a rise in cytosolic free calcium concentration ([Ca2+]i) in fura-2-loaded platelets, and we examined whether this response was due to direct action of PMA2 on CD9 antigen. The rise in [Ca2+]i was dependent on the PMA2 concentration, irrespective of the presence or absence of extracellular Ca2+. The role of secreted adenosine diphosphate (ADP) and thromboxane in the [Ca2+]i response to PMA2 was studied using creatine phosphate/creatine phosphokinase (CP/CPK) and aspirin. Combined treatment with CP/CPK and aspirin abolished the rise in [Ca2+]i, although either CP/CPK or aspirin alone produced only partial inhibition. Inhibition of adenosine triphosphate (ATP) secretion and thromboxane B2 synthesis by an MoAb to the glycoprotein IIb-IIIa complex, PMA1, resulted in little [Ca2+]i response to PMA2. In contrast, thrombasthenic platelets, in which ATP secretion and thromboxane B2 synthesis were normal, showed a normal [Ca2+]i response. When PMA2 was added to CD9+ mononuclear cells, no rise in [Ca2+]i was observed. Thus, we conclude that binding of monoclonal immunoglobulin G molecules to the CD9 antigen raises [Ca2+]i through the effect of secreted ADP and thromboxane on platelets, and that CD9 antigen is not directly involved in induction of Ca2+ influx and mobilization.

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Aspiras, Marcelo B., Karen M. Kazmerzak, Paul E. Kolenbrander, Roderick McNab, Neil Hardegen und Howard F. Jenkinson. „Expression of Green Fluorescent Protein in Streptococcus gordonii DL1 and Its Use as a Species-Specific Marker in Coadhesion with Streptococcus oralis 34 in Saliva-Conditioned Biofilms In Vitro“. Applied and Environmental Microbiology 66, Nr. 9 (01.09.2000): 4074–83. http://dx.doi.org/10.1128/aem.66.9.4074-4083.2000.

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ABSTRACT Streptococcus gordonii is one of the predominant streptococci in the biofilm ecology of the oral cavity. It interacts with other bacteria through receptor-adhesin complexes formed between cognate molecules on the surfaces of the partner cells. To study the spatial organization of S. gordonii DL1 in oral biofilms, we used green fluorescent protein (GFP) as a species-specific marker to identify S. gordonii in a two-species in vitro oral biofilm flowcell system. To drive expression of gfp, we isolated and characterized an endogenous S. gordonii promoter,PhppA, which is situated upstream of the chromosomalhppA gene encoding an oligopeptide-binding lipoprotein. A chromosomal chloramphenicol acetyltransferase (cat) gene fusion with PhppA was constructed and used to demonstrate that PhppA was highly active throughout the growth of bacteria in batch culture. A promoterless 0.8-kb gfp(′gfp) cassette was PCR amplified from pBJ169 and subcloned to replace the cat cassette downstream of the S. gordonii-derived PhppA in pMH109-HPP, generating pMA1. Subsequently, the PhppA-′gfp cassette was PCR amplified from pMA1 and subcloned into pDL277 and pVA838 to generate the Escherichia coli-S. gordonii shuttle vectors pMA2 and pMA3, respectively. Each vector was transformed into S. gordonii DL1 aerobically to ensure GFP expression. Flow cytometric analyses of aerobically grown transformant cultures were performed over a 24-h period, and results showed that GFP could be successfully expressed in S. gordonii DL1 fromPhppA and that S. gordonii DL1 transformed with the PhppA-′gfp fusion plasmid stably maintained the fluorescent phenotype. Fluorescent S. gordonii DL1 transformants were used to elucidate the spatial arrangement ofS. gordonii DL1 alone in biofilms or with the coadhesion partner Streptococcus oralis 34 in two-species biofilms in a saliva-conditioned in vitro flowcell system. These results show for the first time that GFP expression in oral streptococci can be used as a species-specific marker in model oral biofilms.

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Park, Joo Youn, Jong Wan Kim, Bo Youn Moon, Juyeun Lee, Ye Ji Fortin, Frank W. Austin, Soo-Jin Yang und Keun Seok Seo. „Characterization of a Novel Two-Component Regulatory System, HptRS, the Regulator for the Hexose Phosphate Transport System in Staphylococcus aureus“. Infection and Immunity 83, Nr. 4 (02.02.2015): 1620–28. http://dx.doi.org/10.1128/iai.03109-14.

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Hexose phosphate is an important carbon source within the cytoplasm of host cells. Bacterial pathogens that invade, survive, and multiply within various host epithelial cells exploit hexose phosphates from the host cytoplasm through thehexosephosphatetransport (HPT) system to gain energy and synthesize cellular components. InEscherichia coli, the HPT system consists of a two-component regulatory system (UhpAB) and a phosphate sensor protein (UhpC) that tightly regulate expression of a hexose phosphate transporter (UhpT). Although growing evidence suggests thatStaphylococcus aureusalso can invade, survive, and multiply within various host epithelial cells, the genetic elements involved in the HPT system inS. aureushave not been characterized yet. In this study, we identified and characterized the HPT system inS. aureusthat includes thehptRS(a novel two-component regulatory system), thehptA(a putative phosphate sensor), and theuhpT(a hexose phosphate transporter) genes. ThehptA,hptRS, anduhpTmarkerless deletion mutants were generated by an allelic replacement method using a modified pMAD-CM-GFPuv vector system. We demonstrated that bothhptAandhptRSare required to positively regulate transcription ofuhpTin response to extracellular phosphates, such as glycerol-3-phosphate (G3P), glucose-6-phosphate (G6P), and fosfomycin. Mutational studies revealed that disruption of thehptA,hptRS, oruhpTgene impaired the growth of bacteria when the available carbon source was limited to G6P, impaired survival/multiplication within various types of host cells, and increased resistance to fosfomycin. The results of this study suggest that the HPT system plays an important role in adaptation ofS. aureuswithin the host cells and could be an important target for developing novel antistaphylococcal therapies.

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Dorfman, Ruslan, Lillian Glazer, Ulrich Weihe, Mathias F. Wernet und Ben-Zion Shilo. „Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches“. Development 129, Nr. 15 (01.08.2002): 3585–96. http://dx.doi.org/10.1242/dev.129.15.3585.

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The elbow (elB) gene encodes a conserved nuclear protein with a single zinc finger. Expression of ElB is restricted to a specific subset of tracheal cells, namely the dorsal branch and the lateral trunks. Stalled or aberrant migration of these branches is observed in elB mutant embryos. Conversely, ElB misexpression in the trachea gave rise to absence of the visceral branch and an increase in the number of cells forming the dorsal branch. These results imply that the restricted expression of ElB contributes to the specification of distinct branch fates, as reflected in their stereotypic pattern of migration. As elB loss-of-function tracheal phenotypes are reminiscent of defects in Dpp signaling, the relationship between ElB and the Dpp pathway was examined. By using pMad antibodies that detect the activation pattern of the Dpp pathway, we show that Dpp signaling in the trachea is not impaired in elB mutants. In addition, expression of the Dpp target gene kni was unaltered. The opposite is true as well, because expression of elB is independent of Dpp signaling. ElB thus defines a parallel input, which determines the identity of the lateral trunk and dorsal branch cells. No ocelli (Noc) is the Drosophila protein most similar to ElB. Mutations in noc give rise to a similar tracheal phenotype. Noc is capable of associating with ElB, suggesting that they can function as a heterodimer. ElB also associates with the Groucho protein, indicating that the complex has the capacity to repress transcription of target genes. Indeed, in elB or noc mutants, expanded expression of tracheal branch-specific genes was observed.

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Ivanova, Yu A., Z. A. Temerdashev, I. A. Kolychev und N. V. Kiseleva. „Determination of polymeric functional additives in diesel fuel by gel penetration chromatography“. Аналитика и контроль 25, Nr. 1 (2021): 53–62. http://dx.doi.org/10.15826/analitika.2020.25.1.003.

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Current article is devoted to the development of a method for determining polymer functional additives and their molecular weight characteristics in diesel fuel by gel penetration chromatography. The objects of the study were solutions of “C5A”, “Maxoil D”, “Detersol”, polymethymethacrylate “D” (PMAD), “Keropur D ”, Antigel “Difron 3319” and “Superantigel” individual additives as well as the diesel fuel produced by the “Kuban Oil and Gas Company - Ilskiy Oil Refinery”, LLC. The conditions for chromatographic separation and determination of polymeric functional additives were determined considering the analyzed fuel matrix, the working range of the separated masses and molecular weights of analytes, and the composition of the eluent applicable for wide range of analytes. The chromatographic system was calibrated using the narrowly dispersed analytical standard polystyrene samples with molecular weights of 1000, 2000, 4000, 10000, 30,000, 50,000, and 70,000 Da respectively. The molecular weight characteristics were calculated for each functional additive from the analytical standard samples of polystyrene. The method of GPC determination of polymeric functional additives in diesel fuel, along with the concentration characteristics, also makes it possible to determine the molecular weight parameters of wide range of polymeric functional additives; therefore, it is promising for monitoring the quality of the diesel fuel. The proposed analytical scheme was tested in the analysis of real sample of diesel fuel. The GPC scheme for the determination of the “Keroflux 3699” depressant-dispersant additive in diesel fuel included sample preparation using the solid-phase extraction, calibration of the chromatographic system using the standard polystyrene samples, GPC determination of additive components, and the calculation of molecular weight characteristics. The molecular weight characteristics of the “Keroflux 3699” depressant dispersant additive in diesel fuel have been established - the number average and weight average molecular weights equivalent to polystyrene were 10,300 and 8800 Da respectively, and the polydispersity index of the additive was 1.17.

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Tominaga, Hiroshi, Shouichi Kawagishi, Hiroyuki Ashida, Yoshihiro Sawa und Hideo Ochiai. „Structure and Replication of Cryptic Plasmids, pMA1 and pMA2, from a Unicellular Cyanobacterium,Microcystis aeruginosa“. Bioscience, Biotechnology, and Biochemistry 59, Nr. 7 (Januar 1995): 1217–20. http://dx.doi.org/10.1271/bbb.59.1217.

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Gordon, Catharina Yanaga. „PMAC-ESP“. Work 2, Nr. 2 (1992): 31–40. http://dx.doi.org/10.3233/wor-1992-2206.

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Viegas, C. A., P. B. Sebastião, A. G. Nunes und I. Sá-Correia. „Activation of plasma membrane H(+)-ATPase and expression of PMA1 and PMA2 genes in Saccharomyces cerevisiae cells grown at supraoptimal temperatures.“ Applied and environmental microbiology 61, Nr. 5 (1995): 1904–9. http://dx.doi.org/10.1128/aem.61.5.1904-1909.1995.

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Serifoglu, C., O. Gungor und V. Yilmaz. „PERFORMANCE EVALUATION OF DIFFERENT GROUND FILTERING ALGORITHMS FOR UAV-BASED POINT CLOUDS“. ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B1 (03.06.2016): 245–51. http://dx.doi.org/10.5194/isprsarchives-xli-b1-245-2016.

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Digital Elevation Model (DEM) generation is one of the leading application areas in geomatics. Since a DEM represents the bare earth surface, the very first step of generating a DEM is to separate the ground and non-ground points, which is called ground filtering. Once the point cloud is filtered, the ground points are interpolated to generate the DEM. LiDAR (Light Detection and Ranging) point clouds have been used in many applications thanks to their success in representing the objects they belong to. Hence, in the literature, various ground filtering algorithms have been reported to filter the LiDAR data. Since the LiDAR data acquisition is still a costly process, using point clouds generated from the UAV images to produce DEMs is a reasonable alternative. In this study, point clouds with three different densities were generated from the aerial photos taken from a UAV (Unmanned Aerial Vehicle) to examine the effect of point density on filtering performance. The point clouds were then filtered by means of five different ground filtering algorithms as Progressive Morphological 1D (PM1D), Progressive Morphological 2D (PM2D), Maximum Local Slope (MLS), Elevation Threshold with Expand Window (ETEW) and Adaptive TIN (ATIN). The filtering performance of each algorithm was investigated qualitatively and quantitatively. The results indicated that the ATIN and PM2D algorithms showed the best overall ground filtering performances. The MLS and ETEW algorithms were found as the least successful ones. It was concluded that the point clouds generated from the UAVs can be a good alternative for LiDAR data.

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Serifoglu, C., O. Gungor und V. Yilmaz. „PERFORMANCE EVALUATION OF DIFFERENT GROUND FILTERING ALGORITHMS FOR UAV-BASED POINT CLOUDS“. ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B1 (03.06.2016): 245–51. http://dx.doi.org/10.5194/isprs-archives-xli-b1-245-2016.

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Digital Elevation Model (DEM) generation is one of the leading application areas in geomatics. Since a DEM represents the bare earth surface, the very first step of generating a DEM is to separate the ground and non-ground points, which is called ground filtering. Once the point cloud is filtered, the ground points are interpolated to generate the DEM. LiDAR (Light Detection and Ranging) point clouds have been used in many applications thanks to their success in representing the objects they belong to. Hence, in the literature, various ground filtering algorithms have been reported to filter the LiDAR data. Since the LiDAR data acquisition is still a costly process, using point clouds generated from the UAV images to produce DEMs is a reasonable alternative. In this study, point clouds with three different densities were generated from the aerial photos taken from a UAV (Unmanned Aerial Vehicle) to examine the effect of point density on filtering performance. The point clouds were then filtered by means of five different ground filtering algorithms as Progressive Morphological 1D (PM1D), Progressive Morphological 2D (PM2D), Maximum Local Slope (MLS), Elevation Threshold with Expand Window (ETEW) and Adaptive TIN (ATIN). The filtering performance of each algorithm was investigated qualitatively and quantitatively. The results indicated that the ATIN and PM2D algorithms showed the best overall ground filtering performances. The MLS and ETEW algorithms were found as the least successful ones. It was concluded that the point clouds generated from the UAVs can be a good alternative for LiDAR data.

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Viegas, Cristina A., Philip Supply, Etienne Capieaux, Luc Van Dyck, André Goffeau und Isabel Sá-Correia. „Regulation of the expression of the H+-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae“. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1217, Nr. 1 (Januar 1994): 65–73. http://dx.doi.org/10.1016/0167-4781(94)90126-0.

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Lee, Soojeong. „Improved Confidence Interval Estimation for Oscillometric Blood Pressure Measurement by Combining Bootstrap-After-Jackknife Function with Non-Gaussian Models“. Mathematical Problems in Engineering 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/231925.

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Confidence intervals (CIs) are generally not provided along with estimated systolic blood pressure (SBP) and diastolic blood pressure (DBP) measured using oscillometric blood pressure devices. No criteria exist to determine the CI from a small sample set of oscillometric blood pressure measurements. We provide an extended methodology to improve estimation of CIs of SBP and DBP based on a nonparametric bootstrap-after-jackknife function and a Bayesian approach. We use the nonparametric bootstrap-after-jackknife function to reduce maximum amplitude outliers. Improved pseudomaximum amplitudes (PMAs) and pseudoenvelopes (PEs) are derived from the pseudomeasurements. Moreover, the proposed algorithm uses an unfixed ratio obtained by employing non-Gaussian models based on the Bayesian technique to estimate the SBP and DBP ratios for individual subjects. The CIs obtained through our proposed approach are narrower than those obtained using the traditional Studentt-distribution method. The mean difference (MD) and standard deviation (SD) of the SBP and DBP estimates using our proposed approach are better than the estimates obtained by conventional fixed ratios based on the PMA and PE (PMAE).

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Vélez-Uribe, José David, Ana María Mejía-Uñates, Sara Teresa Piedrahita-Roldán, Tatiana Ramírez-Estrada, Nicolás Eugenio Gómez-Suárez und José Ricardo Duque-Ramírez. „Momento aductor de la cadera durante la marcha en adultos mayores asintomáticos“. Universidad y Salud 23, Nr. 3 (31.08.2021): 255–62. http://dx.doi.org/10.22267/rus.212303.239.

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Introducción: El momento articular durante la marcha se ha relacionado con diferentes procesos clínicos en la población adulto mayor, en Colombia no se cuentan con reportes propios. Objetivo: Analizar el momento aductor de la cadera durante la marcha de adultos mayores asintomáticos. Materiales y métodos: Se evaluó a 110 participantes siguiendo las referencias del software VICON NEXUS 2.8.1 modelo Full Body, se utilizó 2 plataformas de fuerza y el volumen de captura estuvo delimitado por 8 cámaras opto eléctricas Bonita 10. Se incluyó variables antropométricas, sociodemográficas, espaciotemporales y cinéticas durante la fase de apoyo, resaltando los dos picos máximos del momento aductor. Resultados: Las cifras del Pico Momento Aductor 1 y 2 (PMA1 y PMA2) fueron de 0,76 y 0,70 Nm/Kg respectivamente, estos picos se relacionaron con masa, talla e índice de masa corporal. Se construyó así una referencia para el análisis de adultos mayores asintomáticos. Conclusiones: La gráfica del momento aductor de la cadera es similar a la descrita por otros investigadores, pero en menor magnitud que en la población sintomática de coxartrosis.

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SAKAI, Masato. „Pyromellitic Dianhydride(PMDA).“ Journal of Synthetic Organic Chemistry, Japan 50, Nr. 7 (1992): 659–60. http://dx.doi.org/10.5059/yukigoseikyokaishi.50.659.

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Wimala, Dina, und Titis Hadiati. „Perbedaan Skor BDI II (Beck depression Inventori) pada siswi dengan PMDD (Premenstrual Dysphoric Disorder) dan non PMDD“. Medica Hospitalia : Journal of Clinical Medicine 8, Nr. 1 (23.03.2021): 21–27. http://dx.doi.org/10.36408/mhjcm.v8i1.486.

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Latar Belakang : Gangguan menstruasi dapat terjadi pada 90 % wanita dan 5-8% nya mengalami gangguan parah yaitu PMDD. 32% remaja perempuan usia 15-19 tahun dimana diagnosis depresi pada remaja lebih sering terlewatkan dibandingkan pada orang dewasa. PMDD dan depresi menyebabkan keluhan psikologis dan berdampak pada kualitas hidup seseorang, karena adanya emosi yang tidak terkontrol, terutama bila tejadi pada remaja. Deteksi PMDD dan depresi pada remaja sering terlewatkan hal ini disebabkan karena gejala yang menonjol adalah lekas marah, reaktivitas susasana hati dan gejala fisik yang tidak dapat dijelaskan sebabnya. Tujuan : Mengetahui perbedaan skor BDI-II pada siswi dengan PMDD dan non PMDD Metode : Penelitian ini merupakan penelitian kuantitatif dengan rancangan belah lintang. Sampel adalah siswi SMK yang memenuhi kriteria inklusi dan eksklusi. PMDD dinilai dengan kuesioner SPAF (Shortened Premenstrual Assessment Form) dan depresi dinilai dengan BDI-II (Beck Depression Inventory-II). Analisa data menggunakan uji Pearson Chi Square, Fisher’s Exact dan Mann Whitney. Hasil : Penelitian ini diikuti oleh 135 responden, 60 (44,4%) responden PMDD dan 75 (55,6%) responden non PMDD dengan median skor BDI-II untuk kelompok PMDD adalah 19 (2-39) dan non PMDD 11 (0-33). Terdapat perbedaan skor BDI-II yang signifikan pada siswi dengan PMDD dan non PMDD dengan p value <0,001. Simpulan : Terdapat perbedaan skor BDI-II yang bermakna pada siswi dengan PMDD dan non PMDD. Kata Kunci : BDI-II, PMDD, remaja

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Fornaro, M., und G. Perugi. „The impact of premenstrual dysphoric disorder among 92 bipolar patients“. European Psychiatry 25, Nr. 8 (Dezember 2010): 450–54. http://dx.doi.org/10.1016/j.eurpsy.2009.11.010.

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AbstractObjectivesTo evaluate the impact of Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition (DSM-IV)-defined premenstrual dysphoric disorder (PMDD) lifetime co-morbidity among 92 bipolar patients.MethodNinety-two women with a lifetime diagnosis of DSM-IV-defined Bipolar Disorder (BD) either type I or type II were consecutively enrolled to determine co-morbidity rates with PMDD and associated clinical features. Measures included the Structured Clinical Interview for the DSM-IV Axis I Disorders (SCID-I) and the Clinical Global Impression (CGI) rating scale.ResultsIn our sample, 25 (27.2%) patients reported a lifetime history of PMDD according to DSM-IV criteria (PMDD+). PMDD+ reported higher rates of Cyclothymia and BP-II than PMDD− (respectively 72% vs. 36% and 88% vs. 60%). On the contrary, the carbohydrate-craving feature was more represented among PMDD− than PMDD+ (25% vs. 4%). PMDD was also significantly associated with post-partum depression (36% vs. 15%), Obsessive-Compulsive (24% vs. 7.5%) and Body Dysmorphic Disorders (24% vs. 6%). Finally, PMDD+ reported higher total number of Axis I co-morbid disorders than PMDD−.ConclusionsIn our cohort of BD women, PMDD is a frequent co-morbid condition, in particular among patients with BD-II or Cyclothymia. Multiple co-morbidities also represent a clinical variable associated with PMDD. Further perspective studies are necessary to better define the relationships between PMDD and BD.

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Xia, Li, Mingyan Zhou, Thomas F. Kalhorn, Horace T. B. Ho und Joanne Wang. „Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity“. American Journal of Physiology-Renal Physiology 296, Nr. 6 (Juni 2009): F1307—F1313. http://dx.doi.org/10.1152/ajprenal.00046.2009.

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Plasma membrane monoamine transporter (PMAT) is a novel polyspecific organic cation transporter that transports organic cations and the purine nucleoside, adenosine. PMAT is expressed in the kidney, but the specific localization and function of this transporter in renal cells are unclear. In this study, we developed a polyclonal antibody toward a 14-amino acid sequence in the last intracellular loop of PMAT and determined the precise cellular localization of PMAT in human and rat kidneys. Surprisingly, we found that the PMAT protein was predominantly expressed in the glomerulus with minimal expression in tubular cells. Within the glomerulus, dual-color immunofluorescence labeling showed that the PMAT protein was specifically localized to the visceral glomerular epithelial cells, i.e., podocytes. There was no significant PMAT immunoreactivity in mesangial or glomerular endothelial cells. We further showed that puromycin aminonucleoside (PAN), a classic podocyte toxin that induces massive proteinuria and severe glomerulopathy, is transported by PMAT. Expression of PMAT in Madin-Darby canine kidney cells significantly increased cell sensitivity to PAN. Decynium 22, a potent PMAT inhibitor, abolished PAN toxicity in PMAT-expressing cells. Together, our data suggest that PMAT is specifically expressed in podocytes and may play an important role in PAN-induced kidney injury.

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Pizzirusso, Maddalena, und Amy Chang. „Ubiquitin-mediated Targeting of a Mutant Plasma Membrane ATPase, Pma1-7, to the Endosomal/Vacuolar System in Yeast“. Molecular Biology of the Cell 15, Nr. 5 (Mai 2004): 2401–9. http://dx.doi.org/10.1091/mbc.e03-10-0727.

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Pma1-7 is a mutant plasma membrane ATPase that is impaired in targeting to the cell surface at 37°C and is delivered instead to the endosomal/vacuolar pathway for degradation. We have proposed that Pma1-7 is a substrate for a Golgibased quality control mechanism. By contrast with wild-type Pma1, Pma1-7 is ubiquitinated. Ubiquitination and endosomal targeting of Pma1-7 is dependent on the Rsp5-Bul1-Bul2 ubiquitin ligase protein complex but not the transmembrane ubiquitin ligase Tul1. Analysis of Pma1-7 ubiquitination in mutants blocked in protein transport at various steps of the secretory pathway suggests that ubiquitination occurs after ER exit but before endosomal entry. In the absence of ubiquitination in rsp5-1 cells, Pma1-7 is delivered to the cell surface and remains stable. Nevertheless, Pma1-7 remains impaired in association with detergent-insoluble glycolipid-enriched complexes in rsp5-1 cells, suggesting that ubiquitination is not the cause of Pma1-7 exclusion from rafts. In vps1 cells in which protein transport into the endosomal pathway is blocked, Pma1-7 is routed to the cell surface. On arrival at the plasma membrane in vps1 cells, Pma1-7 remains stable and its ubiquitination disappears, suggesting deubiquitination activity at the cell surface. We suggest that Pma1-7 sorting and fate are regulated by ubiquitination.

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Carmelo, V., P. Bogaerts und I. Sá-Correia. „Activity of plasma membrane H + -ATPase and expression of PMA1 and PMA2 genes in S accharomyces cerevisiae cells grown at optimal and low pH“. Archives of Microbiology 166, Nr. 5 (28.11.1996): 315–20. http://dx.doi.org/10.1007/s002030050389.

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Yang, Sung-Tae, Song-Yub Shin und Sung-Heui Shin. „The Central PXXP Motif Is Crucial for PMAP-23 Translocation across the Lipid Bilayer“. International Journal of Molecular Sciences 22, Nr. 18 (09.09.2021): 9752. http://dx.doi.org/10.3390/ijms22189752.

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PMAP-23, a cathelicidin-derived host defense peptide, does not cause severe membrane permeabilization, but exerts strong and broad-spectrum bactericidal activity. We have previously shown that it forms an amphipathic α-helical structure with a central hinge induced by the PXXP motif, which is implicated in the interaction of PMAP-23 with negatively charged bacterial membranes. Here, we studied the potential roles of the PXXP motif in PMAP-23 translocation across the lipid bilayer by replacing Pro residues with either α-helix former Ala (PMAP-PA) or α-helix breaker Gly (PMAP-PG). Although both PMAP-PA and PMAP-PG led to effective membrane depolarization and permeabilization, they showed less antimicrobial activity than wild-type PMAP-23. Interestingly, we observed that PMAP-23 crossed lipid bilayers much more efficiently than its Pro-substituted derivatives. The fact that the Gly-induced hinge was unable to replace the PXXP motif in PMAP-23 translocation suggests that the PXXP motif has unique structural properties other than the central hinge. Surface plasmon resonance sensorgrams showed that the running buffer almost entirely dissociated PMAP-23 from the membrane surface, while its Pro-substituted derivatives remained significantly bound to the membrane. In addition, kinetic analysis of the sensorgrams revealed that the central PXXP motif allows PMAP-23 to rapidly translocate at the interface between the hydrophilic and hydrophobic phases. Taken together, we propose that the structural and kinetic understanding of the PXXP motif in peptide translocation could greatly aid the development of novel antimicrobial peptides with intracellular targets by promoting peptide entry into bacterial cells.

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Yen, Lin, Lin, Liu, Long und Ko. „Early- and Late-Luteal-Phase Estrogen and Progesterone Levels of Women with Premenstrual Dysphoric Disorder“. International Journal of Environmental Research and Public Health 16, Nr. 22 (07.11.2019): 4352. http://dx.doi.org/10.3390/ijerph16224352.

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: Objective/introduction: The dynamics of ovarian hormone fluctuations during the luteal phase of the menstruation cycle were previously suggested to contribute to the development of premenstrual dysphoric disorder (PMDD) symptoms, but adequate empirical evidence has not been obtained from hormone concentration studies. We prospectively evaluated estrogen and progesterone levels in the early luteal (EL) and late luteal (LL) phases in women with PMDD and the association of these levels with PMDD symptom severity. Methods: 63 women with PMDD and 53 controls without such severe symptoms were evaluated for the estrogen and progesterone levels, and PMDD severity in the EL and LL phases. Results: The results demonstrated that the women with PMDD had a lower EL-phase estrogen level than the controls. Covariant analysis demonstrated that the interaction term between EL-phase estrogen and EL-phase progesterone level was associated with PMDD severity. Among women with lower EL estrogen levels, higher EL-phase progesterone was observed among the women with PMDD versus controls. These results suggest that low EL-phase estrogen level could moderate the provoking effect of EL progesterone in women with PMDD. Overall, these data suggest a possible role of estrogen and progesterone in the development of PMDD symptoms.

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Yen, Ju-Yu, Pai-Cheng Lin, Mei-Feng Huang, Wei-Po Chou, Cheng-Yu Long und Chih-Hung Ko. „Association between Generalized Anxiety Disorder and Premenstrual Dysphoric Disorder in a Diagnostic Interviewing Study“. International Journal of Environmental Research and Public Health 17, Nr. 3 (05.02.2020): 988. http://dx.doi.org/10.3390/ijerph17030988.

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Background: Premenstrual dysphoric disorder (PMDD) demonstrates predictable, cyclic, affective and somatic symptoms that are aggravated in the late luteal phase and are resolved by menstruation. Generalized anxiety disorder (GAD) is characterized by excessive and persistant worry. The present study aims to evaluate the association between PMDD and GAD. The fluctuations of behavior inhibition, anxiety, depression, and irritability were also evaluated during the menstrual cycle among women with PMDD and healthy women. Methods: There were 100 women diagnosed with PMDD based on a psychiatric interview and on a prospective evaluation in three menstrual cycles. A total of 96 healthy women were recruited as controls. Each individual’s GAD diagnosis, behavior inhibition, behavior activation, depression, anxiety, and irritability were assessed in both luteal and follicular phases. Results: The odds ratio of women with GAD having PMDD was 7.65 (95% CI: 1.69–34.63) in relation to those without it. This association was partially mediated by behavior inhibition and irritability and was completely mediated by depression. Women with PMDD and GAD had higher anxiety during the luteal phase and higher PMDD severity, depression, and irritability than those without GAD in the follicular phase. There is no difference in anxiety, depression, or irritability between the luteal and follicular phases among women with PMDD and GAD. Conclusions: Women with GAD were more likely to have PMDD. Anxiety, depression, and irritability symptoms in women with PMDD and GAD were not relieved in the follicular phase. Thus, GAD should be assessed for women with PMDD. Their anxiety, depression, and irritability should be intervened not only in the luteal phase, but also in the follicular phase. Depression, irritability and behavior inhibition mediated the association between PMDD and GAD. Intervening with these mediators to attenuate GAD and PMDD comorbidity should be researched in the future.

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Borrmann, Thomas, Anton Dominis, Andrew J. McFarlane, James H. Johnston, Michael J. Richardson, Leon A. P. Kane-Maguire und Gordon G. Wallace. „Immobilisation of Fully Sulfonated Polyaniline on Nanostructured Calcium Silicate“. Journal of Nanoscience and Nanotechnology 7, Nr. 12 (01.12.2007): 4303–10. http://dx.doi.org/10.1166/jnn.2007.879.

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Up to 7.4% (w/w) of the sulfonated polyaniline, poly(2-methoxyaniline-5-sulfonic acid) (PMAS) can be absorbed onto nanostructured calcium silicates. Spectroscopic and leaching studies on the novel PMAS-silicate nanocomposites obtained indicate that attachment of the PMAS occurs via electrostatic binding of PMAS sulfonate groups to Ca2+ sites on the silicates. The surface area and pore volume of the nanocomposites are comparable to those of pure silicate and increase the surface area of the PMAS polymer by several orders of magnitude. The PMAS emeraldine salt in the nanocomposites retains its chemical reactivity, being readily oxidised and reduced to its pernigraniline and leucoemeraldine forms, respectively. The conductivity of the composite is comparable to that of the pure PMAS, several orders of magnitude higher than that of dried nanostructured calcium silicate.

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Богданова, Светлана. „Совместный продукт Vatel-PMAT“. Туризм: практика, проблемы, перспективы, Nr. 7 (2005): 26–27.

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Pearlstein, Teri. „PMDD: Definition and Prevalence“. CNS Spectrums 9, Nr. 9 (September 2004): 8–9. http://dx.doi.org/10.1017/s1092852900002005.

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Premenstrual dysphoric disorder (PMDD) is defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) as the presence of at least 5 of 11 symptoms with at least one of the symptoms being depressed mood, anxiety, affective lability, or irritability. The other symptoms include decreased interest in usual activities, poor concentration, fatigue, increased appetite, change in sleep, a sense of being overwhelmed or out of control, and physical symptoms such as breast tenderness. The symptoms must be present in the luteal (premenstrual) phase of the menstrual cycle, must resolve during the first few days of menses, and must have been present for at least 1 year. The symptoms should be severe enough to disrupt social and role functioning. The DSM-IV PMDD criteria include the recommendation that women prospectively rate their symptoms daily for two menstrual cycles to confirm the timing of the symptoms and the absence of a chronic underlying Axis I disorder. Many studies have identified irritability as the most frequently reported premenstrual symptom. It has been proposed that women with PMDD may comprise two subsets; one with predominant depressive symptoms, and another with predominant irritability.

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Loginova, K. B., G. M. Dyukova, Yu E. Dobrokhotova und A. B. Danilov. „Premenstrual dysphoric disorders in women of Russian Federation and risk factors for their development. Epidemiological study of1,326 women“. Medical alphabet 1, Nr. 2 (19.01.2019): 43–46. http://dx.doi.org/10.33667/2078-5631-2019-1-2(377)-43-46.

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The epidemiology of premenstrual dysphoric disorders (PMDD) and the risk factors for PMDD in women of the Russian Federation are still not fully resolved. Objective: to assess the prevalence of PMDD among women in the Russian Federation and to identify risk factors for PMDD. Materials and methods. An anonymous questioning using the questionnaire was carried out by 1326 women of the reproductive period of different regions of the Russian Federation: Moscow (880), Ural (150), Rostov (146) and Novosibirsk (150) regions. Inclusion criteria were: age of 15-45 years, regular menstrual cycle of 25-35 days, lack of psychiatric diagnoses in history. The results. It was found that 15.6 % of Russian women meet the criteria for PMDD. The primary age of the first appearance of PMDD symptoms is 15-19 years. The statistically significant risks of developing PMDD are ages 15-24 years, education at a higher education institution, lack of regular sexual life, history of neurocirculatory dystonia, complication of heredity in neuropsychiatric diseases and premenstrual syndrome, painful periods and complications in childbirth or abortion. Conclusions: the high prevalence of PMDD (15.6 %) in young women of the reproductive period, the presence of psychosocial and biological risk factors for PMDD requires the development of a modified tool for the early diagnosis of PMDD for general practitioners, obstetrician gynecologists, and psychiatrists.

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Moulton, Simon E., Yingpit Pornputtkul, Leon A. P. Kane-Maguire und Gordon G. Wallace. „Poly(2-methoxyaniline-5-sulfonic Acid) - Surfactant Complexes and Their Redox and Solvatochromic Behaviour“. Australian Journal of Chemistry 60, Nr. 3 (2007): 159. http://dx.doi.org/10.1071/ch06378.

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Novel stoichiometric (1:1) complexes between the anionic conducting polymer poly(2-methoxyaniline-5-sulfonic acid) (PMAS) and a range of cationic ammonium surfactants have been prepared and characterized. The supramolecular PMAS–surfactant complexes are stable in chloroform and ethanol solutions, in which the PMAS moiety adopts an ‘extended coil’ conformation. Thin films of the complexes can be cast onto indium tin oxide-coated glass from these solutions. The application of an appropriate applied potential leads to redox switching of the PMAS from the emeraldine salt form to its pernigraniline and leucoemeraldine oxidation states. Immersion of the PMAS–surfactant films in 1.0 M NaOH causes the PMAS moiety to undergo conversion into a ‘compact coil’ conformation rather than alkaline de-doping to the emeraldine base form. When the PMAS–surfactant complexes are dissolved in polar organic solvents such as N,N-dimethylformamide, N-methylpyrrolidinone, and acetone, they undergo marked solvatochromism, which is interpreted in terms of rearrangement of the PMAS polymer chains from an ‘extended coil’ to a ‘compact coil’ conformation.

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Dewi, Tri Kesuma, Purwanta Purwanta und Elsi Dwi Hapsari. „PENGALAMAN IBU DALAM MENGHADAPI ANAK REMAJA DENGAN GEJALA PREMENSTRUAL DYSPHORIC DISORDER“. Berita Kedokteran Masyarakat 34, Nr. 2 (06.02.2018): 72. http://dx.doi.org/10.22146/bkm.31315.

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Mothers experience dealing an adolescent with premenstrual dysphoric disorder symptomsPurposeThe purpose of this study is to explore mothers experience dealing an adolescent with symptoms of the premenstrual dysphoric disorder (PMDD). MethodsThe research used quantitative and qualitative methods. In the quantitative method used with a cross-sectional design using the PMDD symptom questionnaire according to DSM-IV in adolescents, while in a qualitative method using in-depth interview technique on the mother of the adolescent. Data analysis on a quantitative method using descriptive analysis while on qualitative using method of data analysis Colaizi (1973). ResultsThis study showed that 23% or 52 of 226 adolescents had PMDD symptoms and found five themes: 1) the mother knew and felt the symptoms of PMDD experienced by the child, 2) The attitude and the limited time of mother and child affected the delivery of PMDD symptoms of the child to the mother, 3 ) Diversity of the mother's response when the child is facing symptoms of PMDD, 4) The handling that the mother gives to the child when the child has PMDD symptoms is sourced from the past, 5) Mother seeks information about the handling that can be done when experiencing PMDD symptoms. ConclusionMothers play an important role in helping adolescent deal with PMDD symptoms. mothers can provide support, be it instrumental support, assessment, emotional and informational. Mothers should have adequate knowledge of PMDD symptoms so that the support provided can be maximized.

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Luo, Wen-jie, und Amy Chang. „An Endosome-to-Plasma Membrane Pathway Involved in Trafficking of a Mutant Plasma Membrane ATPase in Yeast“. Molecular Biology of the Cell 11, Nr. 2 (Februar 2000): 579–92. http://dx.doi.org/10.1091/mbc.11.2.579.

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The plasma membrane ATPase, encoded by PMA1, is delivered to the cell surface via the secretory pathway. Previously, we characterized a temperature-sensitive pma1 mutant in which newly synthesized Pma1-7 is not delivered to the plasma membrane but is mislocalized instead to the vacuole at 37°C. Severalvps mutants, which are defective in vacuolar protein sorting, suppress targeting-defective pma1 by allowing mutant Pma1 to move once again to the plasma membrane. In this study, we have analyzed trafficking in the endosomal system by monitoring the movement of Pma1-7 in vps36, vps1, andvps8 mutants. Upon induction of expression, mutant Pma1 accumulates in the prevacuolar compartment in vps36cells. After chase, a fraction of newly synthesized Pma1-7 is delivered to the plasma membrane. In both vps1 andvps8 cells, newly synthesized mutant Pma1 appears in small punctate structures before arrival at the cell surface. Nevertheless, biosynthetic membrane traffic appears to follow different routes in vps8 and vps1: the vacuolar protein-sorting receptor Vps10p is stable in vps8 but not in vps1. Furthermore, a defect in endocytic delivery to the vacuole was revealed in vps8 (andvps36) but not vps1 by endocytosis of the bulk membrane marker FM 4-64. Moreover, in vps8 cells, there is defective down-regulation from the cell surface of the mating receptor Ste3, consistent with persistent receptor recycling from an endosomal compartment to the plasma membrane. These data support a model in which mutant Pma1 is diverted from the Golgi to the surface invps1 cells. We hypothesize that in vps8and vps36, in contrast to vps1, mutant Pma1 moves to the surface via endosomal intermediates, implicating an endosome-to-surface traffic pathway.

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