Thematische Bibliographien / PKSim

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Bücher
  4. Buchteile
  5. Konferenzberichte

Auswahl der wissenschaftlichen Literatur zum Thema „PKSim“

Autor: Grafiati
Veröffentlicht am 29. Juni 2021
Zuletzt aktualisiert am 29. Juli 2025

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Zeitschriftenartikel zum Thema "PKSim"

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Li, Ronald C., Shekman L. Wong, and Keith K. H. Chan. "EXPANDED VERSION OF PKSIM FOR PHARMACOKINETIC SIMULATIONS OF BOTH METABOLITE AND PARENT DRUGS." American Journal of Therapeutics 4, no. 1 (1997): 16–22. http://dx.doi.org/10.1097/00045391-199701000-00004.

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Lautz, L., S. Fischer-Holzhausen, and M. Siccardi. "P05-41 Simulations of antibiotics in dairy cattle in PKSim: a case study of sulfadiazine and trimethoprim." Toxicology Letters 399 (September 2024): S147—S148. http://dx.doi.org/10.1016/j.toxlet.2024.07.376.

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Tuffaha, Haya, Laith Alshoaibi, Aya Al-tarawneh, et al. "Therapeutic drug monitoring of digoxin in Jordanian patients: Comparing saliva versus plasma." Journal of Research in Pharmacy 29, no. 4 (2024): 1485–94. https://doi.org/10.12991/jrespharm.1734554.

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Therapeutic drug monitoring (TDM) is measuring drug concentrations in plasma, serum or blood, to assure that drug concentrations can be maintained within a target range and to make sure the amount of medicine being administered is both safe and effective. TDM is essential to avoid digoxin toxicity due to its narrow therapeutic window (therapeutic levels of digoxin are 0.8-2.0 ng/mL. The toxic level is >2.4 ng/mL). TDM of digoxin is currently performed by plasma sampling, which is an invasive and painful procedure. The aim of the study is to study the pharmacokinetics of digoxin in plasma an
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4

Mangzira Kemung, Hefa, Loh Teng-Hern Tan, Kok-Gan Chan, et al. "Streptomyces sp. Strain MUSC 125 from Mangrove Soil in Malaysia with Anti-MRSA, Anti-Biofilm and Antioxidant Activities." Molecules 25, no. 15 (2020): 3545. http://dx.doi.org/10.3390/molecules25153545.

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There is an urgent need to search for new antibiotics to counter the growing number of antibiotic-resistant bacterial strains, one of which is methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report a Streptomyces sp. strain MUSC 125 from mangrove soil in Malaysia which was identified using 16S rRNA phylogenetic and phenotypic analysis. The methanolic extract of strain MUSC 125 showed anti-MRSA, anti-biofilm and antioxidant activities. Strain MUSC 125 was further screened for the presence of secondary metabolite biosynthetic genes. Our results indicated that both polyketide synth
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Saleem, Qurat Ul Ain, Kanwal Ameen, and Murtaza Ashiq. "Personal knowledge and information management practices of life sciences research students in Pakistan." Malaysian Journal of Library & Information Science 26, no. 2 (2021): 107–23. http://dx.doi.org/10.22452/mjlis.vol26no2.6.

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The study investigated personal knowledge and information management (PKIM) practices of life sciences research students and also compared their PKIM practices based on gender and research programme. The study employed survey reserach design in which questionnaire was used to collect data. All MPhil. and PhD. life sciences research students at the University of the Punjab, Lahore, Pakistan were sampled. Altogether 196 questionnaires were distributed and 114 were successfully returned with a response rate of 58 percent. The findings are presented based on the five aspects of PKIM practices of r
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Shahzad, Khurram, Yasir Javed, Shakeel Ahmad Khan, Abid Iqbal, Imran Hussain, and M. Vaseem Jaweed. "Relationship between IT Self-Efficacy and Personal Knowledge and Information Management for Sustainable Lifelong Learning and Organizational Performance: A Systematic Review from 2000 to 2022." Sustainability 15, no. 1 (2022): 5. http://dx.doi.org/10.3390/su15010005.

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This study aims to identify the relationship between IT self-efficacy and personal knowledge and information management (PKIM) practices. It also intends to investigate trending tools and approaches being applied for PKIM for sustainable lifelong learning and organizational performance. It also reveals challenges for the development of an effective PKIM system. To meet the study’s objectives, a systematic literature review was carried out. Fifty research papers published in peer-reviewed journals were included to conduct a comprehensive systematic review. The findings of the study revealed tha
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7

Uchiba, Mitsuhiro, Kenji Okajima, Kazunori Murakami, Hiroaki Okabe, Shosuke Okamoto, and Yoshio Okada. "Effects of Plasma Kallikrein Specific Inhibitor and Active-site Blocked Factor VIIa on the Pulmonary Vascular Injury Induced by Endotoxin in Rats." Thrombosis and Haemostasis 78, no. 04 (1997): 1209–14. http://dx.doi.org/10.1055/s-0038-1657716.

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SummaryThe acute respiratory distress syndrome (ARDS) is a serious complication of sepsis. To evaluate the role of the coagulation system in the pathogenesis of ARDS in sepsis, we examined the effects of the administration of a synthetic plasma kallikrein specific inhibitor (PKSI) and of active-site blocked factor VIIa (DEGR-VIIa) on the pulmonary vascular injury induced by E. coli endotoxin (ET) in rats. Administration of PKSI prevented the pulmonary vascular injury induced by ET as well as pulmonary histological changes in animals administered ET, but it did not affect the intravascular coag
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Kim, Hyo-Sung, Han-Jun Kim, and Sun-Hee Do. "Early Detection of Chronic Kidney Disease Using Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Small-Breed Dogs: A Retrospective Pilot Study." Animals 14, no. 16 (2024): 2313. http://dx.doi.org/10.3390/ani14162313.

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Multiple diagnostic modalities are urgently needed to identify early-stage kidney diseases. Various molecules have been investigated; however, most studies have focused on identifying specific biomarkers in urine. Considering that assessing the symmetrical dimethylarginine (SDMA) plasma concentration is more suitable as an early diagnostic test for chronic kidney disease (CKD) in routine veterinary practice, we aimed to investigate the clinical usefulness of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and plasma kidney injury molecule-1 (pKIM-1) concentrations for CKD detection i
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Ginolhac, Aurélien, Cyrille Jarrin, Benjamin Gillet, et al. "Phylogenetic Analysis of Polyketide Synthase I Domains from Soil Metagenomic Libraries Allows Selection of Promising Clones." Applied and Environmental Microbiology 70, no. 9 (2004): 5522–27. http://dx.doi.org/10.1128/aem.70.9.5522-5527.2004.

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ABSTRACT The metagenomic approach provides direct access to diverse unexplored genomes, especially from uncultivated bacteria in a given environment. This diversity can conceal many new biosynthetic pathways. Type I polyketide synthases (PKSI) are modular enzymes involved in the biosynthesis of many natural products of industrial interest. Among the PKSI domains, the ketosynthase domain (KS) was used to screen a large soil metagenomic library containing more than 100,000 clones to detect those containing PKS genes. Over 60,000 clones were screened, and 139 clones containing KS domains were det
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Mukhtar, Shahid, Ijaz Hussain Wadd, Arsalan Haider, Mohsin Zaheer, and Rashid Imran. "Anosmia in Parkinson’s Disease in Pakistan: A Matched Case – Control Study." Pakistan Journal Of Neurological Surgery 25, no. 4 (2022): 528–36. http://dx.doi.org/10.36552/pjns.v25i4.617.

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Objective: To assess olfactory dysfunction in Parkinson's disease (PD) patients in Pakistan utilizing an autochthonous smell test.
 Setting: Tertiary care center, single-center study.
 Materials and Methods: Eighty-seven non-demented patients with PD, who fulfilled Queen Square Brain Bank Criteria were enrolled at the Movement Disorder Clinic, Lahore General Hospital (LGH), Lahore. Fifty-eight controls matched by gender, age, and place of residence were enrolled among patients and visitors attending other hospital clinics. Both groups underwent olfactory testing using the Pakistani S
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Dissertationen zum Thema "PKSim"

1

Leding, Albin. "Recommendation for first pharmacokinetic in vivo experiment design with a pharmacometric informed approach." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.

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Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. A major reason for discontinuance of a drug under development is undesired pharmacokinetic properties. Therefore, it is important to have early information of this, preferably the first time the drug is tested in animals. The first in vivo pharmacokinetic experiment is often done in mice and the only information prese
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Leding, Albin. "Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.

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Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. A major reason for discontinuance of a drug under development is undesired pharmacokinetic properties. Therefore, it is important to have early information of this, preferably the first time the drug is tested in animals. The first in vivo pharmacokinetic experiment is often done in mice and the only information prese
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Bücher zum Thema "PKSim"

1

Indonesia. Direktorat Kesejahteraan Anak, Keluarga dan Lanjut Usia., ed. Laporan hasil evaluasi pelaksanaan program peningkatan kesejahteraan sosial keluarga muda melalui kelompok usaha bersama keluarga muda mandiri (PKSKM melalui KUBE-KMM). Badan Kesejahteraan Sosial Nasional, Deputi Bidang Peningkatan Kesejahteraan Sosial, Direktorat Kesejahteraan Anak, Keluarga dan Lanjut Usia, 2000.

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pKim Su-yong. Hyehwadang, 1993.

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Buchteile zum Thema "PKSim"

1

Enna, S. J., and David B. Bylund. "PKSI-527." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63458-0.

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Konferenzberichte zum Thema "PKSim"

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Ahmad, Azlin, Rubiyah Yusof, and Yasue Mitsukura. "Pheromone-based Kohonen Self-Organizing Map (PKSOM) in clustering of tropical wood species: Performance and scalability." In 2015 10th Asian Control Conference (ASCC). IEEE, 2015. http://dx.doi.org/10.1109/ascc.2015.7244589.

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