Auswahl der wissenschaftlichen Literatur zum Thema „Photo-uncaging“
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Zeitschriftenartikel zum Thema "Photo-uncaging"
Perdue, Lacey A., Priscilla Do, Andrew Chyong, Emma Costanza, Hye Ryong Kim, Camille David, Anna Kellner et al. „Chemical modification strategies for photo-induced control of immune cell signaling“. Journal of Immunology 204, Nr. 1_Supplement (01.05.2020): 221.1. http://dx.doi.org/10.4049/jimmunol.204.supp.221.1.
Der volle Inhalt der QuelleSambath, Karthik, Tinghan Zhao, Zhaoxiong Wan und Yuanwei Zhang. „Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells“. Chemical Communications 55, Nr. 94 (2019): 14162–65. http://dx.doi.org/10.1039/c9cc07199g.
Der volle Inhalt der QuelleIchimura, Hideo, Kaushik Parthasarathi, Jens Lindert und Jahar Bhattacharya. „Lung surfactant secretion by interalveolar Ca2+ signaling“. American Journal of Physiology-Lung Cellular and Molecular Physiology 291, Nr. 4 (Oktober 2006): L596—L601. http://dx.doi.org/10.1152/ajplung.00036.2006.
Der volle Inhalt der QuelleWang, Haopei, und Zachary T. Ball. „A photochemical C=C cleavage process: toward access to backbone N-formyl peptides“. Beilstein Journal of Organic Chemistry 17 (15.12.2021): 2932–38. http://dx.doi.org/10.3762/bjoc.17.202.
Der volle Inhalt der Quellede Sousa, Aurideia P., Ana C. S. Gondim, Eduardo H. S. Sousa, Mayron A. de Vasconcelos, Edson H. Teixeira, Beatriz Pinheiro Bezerra, Alejandro Pedro Ayala, Patrícia H. R. Martins, Luiz Gonzaga de França Lopes und Alda K. M. Holanda. „An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity“. JBIC Journal of Biological Inorganic Chemistry 25, Nr. 3 (14.03.2020): 419–28. http://dx.doi.org/10.1007/s00775-020-01772-5.
Der volle Inhalt der QuelleLee, Shin-Rong, Paul J. Adams und David T. Yue. „Large Ca2+-dependent facilitation of CaV2.1 channels revealed by Ca2+photo-uncaging“. Journal of Physiology 593, Nr. 13 (30.06.2015): 2753–78. http://dx.doi.org/10.1113/jp270091.
Der volle Inhalt der QuelleRong Lee, Shin, Manu B. Johny und David T. Yue. „Large Ca2+-Dependent Facilitation of CaV2.1 Channels Induced by Ca2+ Photo-Uncaging“. Biophysical Journal 104, Nr. 2 (Januar 2013): 461a. http://dx.doi.org/10.1016/j.bpj.2012.11.2549.
Der volle Inhalt der QuelleHöglinger, Doris, André Nadler, Per Haberkant, Joanna Kirkpatrick, Martina Schifferer, Frank Stein, Sebastian Hauke, Forbes D. Porter und Carsten Schultz. „Trifunctional lipid probes for comprehensive studies of single lipid species in living cells“. Proceedings of the National Academy of Sciences 114, Nr. 7 (02.02.2017): 1566–71. http://dx.doi.org/10.1073/pnas.1611096114.
Der volle Inhalt der QuelleLeonidova, Anna, Vanessa Pierroz, Riccardo Rubbiani, Yanjun Lan, Anita G. Schmitz, Andres Kaech, Roland K. O. Sigel, Stefano Ferrari und Gilles Gasser. „Photo-induced uncaging of a specific Re(i) organometallic complex in living cells“. Chemical Science 5, Nr. 10 (09.06.2014): 4044. http://dx.doi.org/10.1039/c3sc53550a.
Der volle Inhalt der QuellePickens, Rachael N., Grace L. Judd und Jessica K. White. „Photo-uncaging a Ru(ii) intercalator via photodecomposition of a bridged Mn(i) photoCORM“. Chemical Communications 57, Nr. 62 (2021): 7713–16. http://dx.doi.org/10.1039/d1cc02371c.
Der volle Inhalt der QuelleDissertationen zum Thema "Photo-uncaging"
Labro, Marine. „Synthèse de nouvelles prodrogues photoactivables ciblant les G-quadruplexes : étude de la photoréaction et design moléculaire pour améliorer la biocompatibilité et l'efficacité d'une nouvelle thérapie anti-cancer“. Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0020.
Der volle Inhalt der QuelleCancer is a major public health problem: in 2020, it caused the death of approximately 10 million people worldwide, equivalent to one in six deaths. Recent research efforts against cancer have led to the emergence of targeted and innovative therapies. These advancements aim to minimize collateral damage to healthy cells and reduce side effects in treated patients, while ensuring maximum treatment efficacy for tumor eradication. In this thesis, we study a new original photochemical reaction allowing the development of a new photoactivatable anti-cancer prodrug. From a helical molecule of bis-quinoline type, an intramolecular double SNAr* photoreaction leads to the formation of an extended diazonia, a G-quadruplexes ligand which is fluorescent and capable of generating cytotoxic singlet oxygen. Thus, this photochemical reaction facilitates the development of a novel anti-cancer treatment at the intersection of photodynamic therapy and photo-uncaging. Furthermore, light serves as a non-harmful external stimulus within a certain range of wavelengths (particularly infrared), allowing controlled spatiotemporal drug release, rendering the prodrug's mode of action highly targeted and promising. In this thesis, we apprehended the mechanism of the photoreaction by studying the effect of different physico-chemical experimental parameters. Also, we rationalized the influence of the nature of the leaving group on the efficiency of the double SNAr* on the quantum yield of the photoreaction. Then, we improved the design of the prodrug for its biological application in order to 1) ensure treatment biocompatibility by triggering the photoreaction in the biological transparency window, 2) enhance prodrug cellular internalization, and 3) develop a combined therapy by associating multiple anticancer agents and implementing targeting strategies
Klausen, Maxime. „Nouvelles sondes moléculaires photo-activées pour la délivrance de principes actifs : de la conception aux applications biologiques“. Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0077.
Der volle Inhalt der QuellePhotolabile protecting groups (PPGs) have attracted growing interests in many fields of chemistry and biology. Light-induced release of biological agents, commonly known as “uncaging”, has thus emerged as an interesting process for drug delivery or investigation of biological phenomena. Combining this tool with the intrinsic advantages of two-photon (2P) excitation (2PE) in the NIR is however a challenge. In this work, we use different engineering routes towards new efficient 2P uncagers.First we demonstrate that combining quadrupolar 2P light harvesting antennas with suitable uncaging subunits leads to efficient release of active molecules upon 2PE. In these FRET-based systems, gradual adjustments of the constitutive building blocks allowed us to tune key parameters such as photophysical properties, FRET efficiency, and kinetics of photorelease. In particular, coumarin-based tandem systems, in which absorption and emission of the donor-acceptor pair best match, eventually led to record δu values for uncaging of carboxylic acids.We then assessed the critical water-solubility issue by introducing hydrophilic units onto our cooperative PPGs. New hydrophilic and amphiphilic systems, suited for controlled release of neurotransmitters or anti-cancer agents, were designed from our multi-chromophoric systems.Finally, in our effort towards better understanding of the structure-properties relationships in coumarin PPGs, we synthesized a small library of π-extended DEAC cages bearing strong electron-withdrawing moieties, and assessed their efficacy for 2P uncaging of glycine. With this study, a step was made towards rationalization of the uncaging quantum yield in coumarin cages
Dubois, Victor. „Nouveaux outils moléculaires photo-activables pour la délivrance contrôlée de principes actifs : De la conception aux applications biologiques“. Thesis, Bordeaux, 2021. http://www.theses.fr/2021BORD0029.
Der volle Inhalt der QuellePhotosensitive protecting groups (PPGs) are small organic chromophores able to release bioactive compounds thanks to light irradiation. Such molecular tools have attracted a growing interest in the field of biology for applications such as therapy or physiology. However, while most PPGs possess satisfying photochemical properties for 1-photon excitation, designing efficient PPGs for 2-photon excitation (2PE) in the NIR region is still very challenging. In this work, we decided to use two different approaches towards new efficient PPGs for two-photon (2P) induced photorelease.First, we decided to investigate the direct modification of the molecular structure of coumarinyl PPGs in order to enhance their 2P absorption (2PA) ability. In this context, the synthesis of PPGs with modified - conjugated and push-pull systems combined with the introduction of molecular symmetry led to a set of very efficient PPGs for 2PE. In addition, a small library of dipolar PPGs bearing electron withdrawing groups allowed us to make a step towards the rationalization of the uncaging quantum yield. One of our new compounds is currently being submitted to neurophysiological experiments to validate our strategy.The second part of this work concerns the conception of energy transfer (FRET or PET) based tandem systems between a strong 2P absorber antennae and appropriate PPG. Again, the photophysical and photochemical studies of our new compounds showed very high 2P photosensitivity. While these last results contributed to validate our strategy, some of the disappointing results obtained also contributed to point out the key parameters required in the elaboration of such architectures
Buchteile zum Thema "Photo-uncaging"
Ford, Peter C. „Adventures in the photo-uncaging of small molecule bioregulators“. In Advances in Inorganic Chemistry. Elsevier, 2022. http://dx.doi.org/10.1016/bs.adioch.2022.04.002.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Photo-uncaging"
Sinton, David, und Dongqing Li. „Microscale Flow Visualization“. In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-39577.
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