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Arcelus, Jon. „Juan Manuel Mancilla Diez and Gilda Gomez Perez-Mitre (Eds.) (2006). ‘Trastornos alimentarios en Hispanoamerica’ (Eating disorders in Hispanic-America), Manual Moderno Publisher: Mexico, p. 250, ISBN 970-729-216-4“. European Eating Disorders Review 15, Nr. 5 (2007): 400. http://dx.doi.org/10.1002/erv.799.
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Cobos, Josselyn Sofia Vergara, Francisco Carrillo-Perez, Marija Pizurica, Noemi Andor und Olivier Gevaert. „Abstract LB390: Enhancing prostate cancer diagnosis: A deep learning approach for DNA ploidy prediction from whole slide images“. Cancer Research 84, Nr. 7_Supplement (05.04.2024): LB390. http://dx.doi.org/10.1158/1538-7445.am2024-lb390.
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Abstract Prostate cancer is distinguished by unique histological alterations in glandular architecture, observable in Whole Slide Images (WSIs). The disease is further characterized by pronounced genomic instability, exemplified by biomarkers such as DNA ploidy. While the Gleason Score effectively assesses the histological changes, the manual evaluation of DNA ploidy is subjective and time-consuming. Addressing the need for an objective diagnostic tool, our study developed a deep learning model aimed at accurately predicting DNA ploidy using publicly available WSI from the Cancer Genome Atlas (TCGA). Utilizing a ResNet-18 convolutional neural network, we trained the model on WSIs from 200 TCGA patients to extract features and predict total mRNA expression. The model was further refined using data from 19 TCGA patients, focusing on ploidy number prediction. Comparative analysis against a random reference model revealed significant improvements of ploidy prediction in Mean Absolute Error (MAE) by 43.52%, Mean Absolute Percentage Error (MAPE) by 43.59%, and Mean Squared Error (MSE) by 67.86%. These enhancements were statistically validated (p-values: MAE - 7.07E-06, MAPE - 7.69E-06, MSE - 3.14E-05) and substantiated by large Cohen's d values (MAE - 2.88, MAPE - 2.86, MSE - 2.42), confirming the model's advanced predictive accuracy and practical utility. This approach, validated further on a separate TCGA hold-out test set, signifies a major leap in prostate cancer diagnostics. By integrating mRNA prediction checkpoints, our model not only refines ploidy assessment but also sets the stage for correlating these predictions with patient clinical outcomes. These developments promise to enhance existing diagnostic methods, offering a more objective and efficient tool for DNA ploidy assessment in prostate cancer prognosis and treatment planning. Citation Format: Josselyn Sofia Vergara Cobos, Francisco Carrillo-Perez, Marija Pizurica, Noemi Andor, Olivier Gevaert. Enhancing prostate cancer diagnosis: A deep learning approach for DNA ploidy prediction from whole slide images [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB390.
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Rodríguez, Tania, und Ángel Sermeño. „PENSAR LA UNIVERSIDAD, HACER UNIVERSIDAD ENTREVISTA CON MANUEL PÉREZ ROCHA“. Andamios, Revista de Investigación Social 3, Nr. 5 (23.08.2006): 259. http://dx.doi.org/10.29092/uacm.v3i5.335.
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Mahmoud, Yamil D., Natalia Rego, Marcela Vilarino, Florencia Veigas, Maria R. Girotti, Juan M. Perez Saez, Gabriel A. Rabinovich und Marcelo Hill. „Abstract 6548: Bioinformatic characterization of dendritic and T cell subpopulations in the tumor microenvironment across different cancer types by single-cell RNA-Seq analysis“. Cancer Research 83, Nr. 7_Supplement (04.04.2023): 6548. http://dx.doi.org/10.1158/1538-7445.am2023-6548.
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Abstract Although the development of single-cell RNAseq (scRNAseq) has improved the knowledge of the tumor microenvironment (TME), there is not a clear understanding of specific cell subtypes, markers that define these cell populations, nor the interaction between them. Previously, we showed that inflammasome activation is correlated with antitumor responses triggered by immune checkpoint blockade (ICB). This highlights a central role for TMEM176B, mostly expressed in myeloid cells, that impairs the recruitment of cytotoxic immune cells in the TME by inhibiting NLRP3 inflammasome activation. Still, the roles of the different subsets of myeloid and T cells in the TME and to what extent they are connected remain controversial. Here, we used scRNAseq data from human tumors to identify and characterize cDC2, Th17 and exhausted CD8+ T cell subpopulations in cancer. Five scRNAseq data sets of melanoma, basal cell carcinoma, breast, lung, colorectal, and ovary cancer patients were integrated, accounting for 382,019 immune cells in total. We applied and compared different bioinformatic tools for scRNASeq data normalization and data sets integration to find conserved immune cell populations across samples, data sets, and cancer types. Then, we evaluated different parameters using well-established methods for clustering and cell type classification to identify subtypes of DCs and T cells in the integrated data. We combined automatic methods with manual analysis of cluster markers to improve robustness and confidence in the cell populations identified. Three clusters of cDC2 were defined and characterized using different scRNAseq analysis tools for pathway enrichment analysis and transcription factors (TF) activation prediction. We found a subset of inflammatory cDC2 with high gene expression of IL1B and NLRP3, in contrast with another cluster characterized by high expression of TMEM176B and CD14. A third cluster showed an intermediate transcriptomic profile. The TMEM176B+ CD14+ cluster was characterized by the activation of JAK-STAT and hypoxia pathways, and the TF FOXL2, ETS2, and ESR2. The NLRP3+ IL1B+ cluster showed more activation of MAPK, Trail, and PI3K pathways, and the TF CEBPE. Moreover, the activation of TNFα and NFkB signaling pathways was found in both clusters. In addition, a conserved population of Th17 cells in the integrated data was observed. Th17 cells were heterogeneous, making the subpopulations and transcriptome signature difficult to define. Further analysis is being performed to identify Th17 subsets and their potential interactions with the cDC2 subclusters. A robust identification and characterization of these immune cell subsets will build towards our understanding of the interactions between these subpopulations triggered by inflammasome activation within the TME and the mechanisms behind ICB response. Citation Format: Yamil D. Mahmoud, Natalia Rego, Marcela Vilarino, Florencia Veigas, Maria R. Girotti, Juan M. Perez Saez, Gabriel A. Rabinovich, Marcelo Hill. Bioinformatic characterization of dendritic and T cell subpopulations in the tumor microenvironment across different cancer types by single-cell RNA-Seq analysis. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6548.
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Kang, Ziqi, Teodora Farago, Angela Szabo, Inga-Maria Launonen, Fernando Perez, Ella Anttila, Kevin Elias, Julia Casado, Peter Sorger und Anniina Färkkilä. „Abstract A103: Improved cell phenotyping of ovarian cancer tumor microenvironment“. Cancer Research 84, Nr. 5_Supplement_2 (04.03.2024): A103. http://dx.doi.org/10.1158/1538-7445.ovarian23-a103.
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Abstract Introduction: Multiplexed imaging at single-cell resolution is becoming widely used to decipher the role of the cellular microenvironment in cancer and other complex diseases. To identify spatial patterns of single cells on a tissue, accurate cell-type phenotyping is a crucial step. We present Tribus, an interactive, semi-supervised classifier that avoids thresholds and manual labeling, with user-friendly visualization of the results and automated quality control reports. Materials and Methods: We developed Tribus, an open-source Python 3 software utilizing self-organizing maps for data clustering with an integrated Napari plug-in for fast visualization. It assigns the cell phenotypes based on user-defined label description tables and median marker expressions, following a hierarchical structure to minimize overspill bias. It has a modular architecture and can be run via command line, Jupyter Notebook, or the Napari interface. For exploring the Tribus performance, we used 1) manually expert annotated datasets with different tissue origins 2) dataset with cluster-based annotation 3) previously unpublished dataset. To ensure usability, we utilized datasets generated by using different multiplexed imaging technologies, and of variable size including large tissue microarrays and whole-slide images. Results: Using Tribus we accurately annotated the cell phenotypes in an expert-labeled Co-detection by indexing (CODEX) dataset, consisting of 8 regions of tissue samples from a single donor, including both healthy colon and small bowel sections. Tribus analysis of a high-grade ovarian cancer (HGSC) tumor microarray dataset generated by tCyCIF revealed a subset of lymphoid cells previously mislabelled using a cluster annotation approach. Finally, we utilized Tribus for deep cell phenotyping on a large whole-slide image tCyCIF dataset consisting of over a million cells from five matched HGSC samples collected before and after neoadjuvant chemotherapy (NACT). In the paired samples we successfully identified cell subtypes crucial for immune surveillance. Our analysis accurately differentiated M1 and M2 macrophage subpopulations. In addition, the analyzed post-NACT samples showed a higher proportion of tumor-infiltrating CD8+ T-cells, interestingly displaying occasional spatial clusters by the tumor borders. Therefore, Tribus has shown a great potential to study the spatial patterns and cell-cell interactions of relevant immune cells in response to neoadjuvant chemotherapy treatment. Conclusion: Overall, Tribus is an accurate, fast and efficient way to analyze different sizes of datasets across different technologies, resulting in accelerated analysis of the spatial tumor microenvironment (TME). The accurate cell-type phenotyping with Tribus uncovered high-resolution cellular phenotypes and their spatial patterns in the TME in ovarian cancer after neoadjuvant chemotherapy. Citation Format: Ziqi Kang, Teodora Farago, Angela Szabo, Inga-Maria Launonen, Fernando Perez, Ella Anttila, Kevin Elias, Julia Casado, Peter Sorger, Anniina Färkkilä. Improved cell phenotyping of ovarian cancer tumor microenvironment [abstract]. In: Proceedings of the AACR Special Conference on Ovarian Cancer; 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_2):Abstract nr A103.
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García-Meléndez, Eduardo, Raquel Ribeiro, José Carlos Brito und Neftalí Sillero. „Estimating altitude in distribution records of Amphibians and Reptiles: a comparative study between topographic maps and Remote Sensing data“. Amphibia-Reptilia 29, Nr. 1 (2008): 121–26. http://dx.doi.org/10.1163/156853808783431532.
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Abstract Altitude is an important factor when explaining species distributions. However, many biogeographical studies register altitude directly through topographic maps; a time-consuming manual process prone to mistakes. Currently, GIS and DEMs allow this work to be done more efficiently. Two methods for registering altitude for locations of amphibians and reptiles in the Iberian Peninsula were compared in order to evaluate their efficiency and similarity: manually through topographic maps, and automatically with a GIS, where two DEMs were analysed: the SRTM DEM and a DEM generated through topographic maps. The SRTM altitudes were similar to those recorded by the manual method (only Rana perezi presented differences), whereas the other DEM had differences in almost all amphibians and three reptiles. The differences between both DEMs corresponded mostly to rivers and band effect of radar sensor. The GIS method was faster, efficient and no time was consumed in searching and correcting human errors.
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Livesey, Graham. „From the infraordinary to the extraordinary: Georges Perec and domesticity“. Architectural Research Quarterly 26, Nr. 3 (September 2022): 247–53. http://dx.doi.org/10.1017/s1359135522000471.
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The design of domestic environments is fraught with decision-making, a process often dictated by fashion. The resulting inhabitation of domestic spaces blends the routine and the banal, with occasional forays into the extraordinary. The spaces of the domesticity range from single rooms to elaborate palaces. These can be functionally prescribed or open-ended, they support furniture, décor, behaviours, and narratives. The writer Georges Perec (1936–82) provides a way of looking at the domestic realm and ordinary life through his many inter-related writings on the subject. In his quest for an ‘anthropology of everyday life’, he explored notions of the ‘ordinary’ and ‘infraordinary’. In this text two important works by Perec are examined to explore how he framed and questioned notions of domesticity; can this reading be construed as a theory of domesticity?Perec’s text Species of Spaces describes a spatial continuity between city and dwelling that is characterised by spatial types, thresholds/boundaries, objects, and everyday practices often of an autobiographical nature. He begins with the page, ascends through the apartment building and the city, and ends with the world in a sequence of embedded spatial conditions. A close read of Species of Spaces uncovers a kind of sociological work, a critique or manifesto, and an evolution from Perec’s previous writings. In the text he asks the most fundamental questions, such as ‘What does it mean, to live in a room?’In his monumental text Life A User’s Manual, Perec examines the lives of residents in a typical Parisian apartment building, it remains one of the most significant imaginings of how a building, or work of architecture, can be occupied. Through the vast scope of Perec’s project the book captures the intertwining lives of the occupants of the building at 11 Rue Simon-Crubellier, in Paris’s 17th arrondissement, at precisely 8:00 pm on 23 June 1975. To accomplish this Perec devised forty-two ‘preprogrammed’ factors to structure each of the ninety-nine chapters to ensure that he covered plot, actors, and setting in a systematic way. The apartment building ultimately provides an armature for the study of the very small to the very large.Life A User’s Manual describes a domestic world, how we organise our residences into compartments of space, how we furnish the rooms, how our stories create our realities, and how the lives of people in an ordinary apartment building intertwine in so many ways. Although frozen in a moment, the novel captures the vagaries and complexities of the everyday. It describes the routines of living, unexpected happenings, the connections between people living together at close quarters, the role of interiors in defining a particular period, the histories that can support and damage a life, the common aspirations and tragedies of urban dwellers, and so on. Perec's work does not constitute an actual theory of domesticity, although it precisely describes a domestic order that provides a sense of place by attending to both the minor and major aspects of an environment.
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Anggraeni, Frida Dwi, und Suprihana Suprihana. „PENINGKATAN KUALITAS PRODUKSI MAKANAN TRADISIONAL GETHUK LINDRI DI MOJOLANGU KOTA MALANG“. Conference on Innovation and Application of Science and Technology (CIASTECH) 6, Nr. 1 (30.12.2023): 949. http://dx.doi.org/10.31328/ciastech.v6i1.5360.
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Gethuk lindri terbuat dari singkong yang telah diolah dan dicampur dengan gula pasir. Makanan ini memiliki tekstur yang kenyal dan manis. Permasalahan mitra dalam bidang produksi, mitra menggunakan alat penggiling yang masih manual dengan pemutar tuas untuk menghancurkan singkong menjadi pasta singkong. Mitra sering mengeluhkan sakit pada bahu karena memutar alatnya secara manual. Selain itu, waktu penggilingan juga lebih lama dan kurang efisien. Selain itu, dari segi kualitas, kurangnya pengetahuan mitra mengenai batas maksimum penggunaan bahan pewarna makanan sintetis. Hasil dari pengabdian ini adalah pengadaan alat penggiling/pelumat singkong dengan penambahan mesin dinamo, pendampingan penggunaan alat penggiling dengan dinamo, serta pelaksanaan penyuluhan kepada mitra mengenai penggunaan bahan pewarna makanan sintetis yang aman. Alat penggiling singkong dengan penambahan mesin dinamo ini dapat meningkatkan produksi sebesar 60% dibanding alat penggiling secara manual, yaitu yang awalnya proses penggilingan 10 kg / jam, bisa meningkat menjadi 30 kg / jam. Kemudian dalam meningkatkan kualitas dan keamanan pangan gethuk lindri, batas maksimum penggunaan pewarna makanan sintetis seperti tartrazine adalah 70 mg / kg makanan atau 1 sendok teh peres untuk 43 kg adonan atau berdasarkan ADI 0 – 7,5 mg/kg berat badan.
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Puerto álvarez, Jose Ramón. „Crónica de dos premios del Colegio Oficial de Arquitectos de Asturias: CASTELAO y COAA+10, o como premiar el paso del tiempo en la Arquitectura.“ Liño 24, Nr. 24 (26.07.2018): 139. http://dx.doi.org/10.17811/li.24.2018.139-144.
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Comentario sobre los dos premios de arquitectura de reciente creación que premian una trayectoria profesional (el Castelao) y la obra de más de 10 años que haya sabido mantener su propuesta arquitectónica a través del tiempo. El primero se concedió al arquitecto gijonés Mariano Marín Rodríguez Rivas y el segundo al Edificio Administrativo de Servicios Múltiples del Principado de Asturias de Oviedo, realizado por los arquitectos Manuel y Enrique Hernández Sande junto con Enrique Perea Caveda.
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Caunedo del Potro, Betsabé. „Algunos aspectos de los manuales de mercaduría. El valor del aprendizaje. La pereza es llave de la pobreza“. Anuario de Estudios Medievales 41, Nr. 2 (30.12.2011): 803–17. http://dx.doi.org/10.3989/aem.2011.v41.i2.372.
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Stauder, S., und P. M. Peloso. „POS1125 DUAL ENERGY CT HAS PROGNOSTIC VALUE IN GOUT BEYOND STANDARD CLINICAL MEASURES: A BEST EVIDENCE SYNTHESIS“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 841.2–842. http://dx.doi.org/10.1136/annrheumdis-2021-eular.872.
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Background:Dual Energy CT Scan (DECT) can detect monosodium urate crystal deposits in multiple tissues. EULAR gout guidelines (Richette, 2020) recognized the value of DECT in making a clinical diagnosis when joint aspiration is difficult. DECT shows crystal deposits in almost 50% of gout patients without tophi (Dalbeth, 2017). Tophi are known to predict all-cause and cardiovascular mortality (Vincent 2017, Perez-Ruiz 2013) and it is plausible that DECT could as well. A prognostic measure should be reliable and valid. DECT validity would be evident for death, disability and distress.Objectives:This study used a best evidence synthesis approach to synthesize the evidence for DECT as a prognostic measure in gout.Methods:PUBMED and EMBASE were searched from initiation to December 2019; keywords (Dual Energy Computed Tomography OR DECT, gout, tophaceous gout, chronic gout, monosodium urate crystals OR monosodium urate burden OR tophi OR monosodium urate volume OR flares OR pain OR distress OR death OR disability OR function). Human studies in English were considered. Titles, abstracts and full articles were reviewed. A manual search of secondary sources was conducted. Key gaps identified were considered throughout 2020 when reviewing emerging articles and presentations. Data extraction was conducted by both authors; data presented represents consensus.Results:Of 344 articles, 81 titles/abstracts met screening inclusion criteria (24%) in the 2019 search; review of the full manuscript led to 41 articles selected (51%). Additionally, 3 key papers and 2 ACR 2020 presentations were identified through 2020. DECT is highly reliable with inter-class correlation coefficients >0.9. DECT has content validity. Dalbeth (2015) showed DECT and X-Rays findings correlated in tophaceous patients, r=0.70, p<0.001. Hand function correlates with DECT burden, with r2=0.59, p=0.024 (Dalbeth 2007). Dalbeth (2017) showed DECT associated with greater flares at 3 and 12 months (p<0.01) in 152 patients. Pascart (2018) confirmed that subjects with flares had nearly doubled DECT feet volumes (0.9 vs 2.1 cm3, p=0.05) versus those not flaring. Dalbeth (2017) showed abnormal DECT scans occurred in 47% of patients with normal uric acid (<6.0 mg/dL) without palpable tophi and in 90% with elevated uric acid and palpable tophi. DECT is very sensitive to change (Araujo 2015) with 95% volume reduction in 152 patients on pegloticase treated up to 12 months. Three studies show DECT is correlated to cardiovascular risk factor prevalence (Pascart 2020, Gamala 2018, Lee 2017). Marty-Ané reported that DECT volume predicts mortality (Marty-Ané ACR 2020). Limited evidence from 3 studies suggests that the minimum important volume for DECT is 1.0 cm3 at feet and ankles, including Pascart 2020.Conclusion:DECT imaging is highly reliable, has evidence for content validity and is highly sensitive to change. DECT appears to predict future gout flares, cardiovascular risk factor prevalence and mortality. Minimum important DECT volume approximates 1.0 cm3. DECT requires further study but appears to be a relevant outcome for clinical trials and staging gout patients.References:AuthorsJournal, Volume, IssueYearAraujo, E. G., Bayat, S., et al.RMD Open2015Dalbeth, N., Nicolaou, S., et al.Ann Rheum Dis, 77(3)2017Dalbeth, N., Aati, O., et al.Ann Rheum Dis, 74(6)2015Dalbeth, N., Collis, J., et al.Rheumatology, 46(12)2007Gamala, M., Linn-Rasker, S. P., et al.Clinical Rheumatol, 37(7)2018Lee, K., Ryu, S., et al.Clinical Rheumatol, 372017Marty-Ané, A., Norberciak, L., et al.Arthritis Rheumatol 72 (supp 10) [abstract #0954] ACR 2020.2020Pascart, T., Ramon, A., et al.J Clin Med, 9(5)2020Pascart, T., Capon, B., et al.Arthritis Res and Therapy, 20(1)2018Perez-Ruiz, F., Martínez-Indart, L., et al.Ann Rheum Dis, 73(1)2013Richette, P., Doherty, M., et al.Ann Rheum Dis, 79(1)2020Vincent, Z., Gamble, G., et al.J Rheumatol, 44 (3)2017Disclosure of Interests:Sally Stauder: None declared, Paul M. Peloso Shareholder of: Horizon Therapeutics plc, Employee of: Horizon Therapeutics plc.
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Ortego Rico, Pablo. „MORELLÓ BAGET, Jordi; ORTI GOST, Pere; VERDÉS PIJUAN, Pere (eds.), Renda feudal i fiscalitat a la Catalunya Baixmedieval. Estudis dedicats a Manuel Sánchez Martínez“. Edad Media. Revista de Historia, Nr. 21 (13.07.2020): 527–31. http://dx.doi.org/10.24197/em.21.2020.527-531.
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Stalling, Gregory. „Sabotajes musicales y cinematográficos en la poesía juvenil de Pere Gimferrer“. Quaderns de Filologia - Estudis Literaris 25 (17.12.2020): 83. http://dx.doi.org/10.7203/qdfed.25.18985.
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Este ensayo se inspira en la crítica como sabotaje de Manuel Asensi para analizarlas colecciones de poemas La muerte en Beverly Hills y De “Extraña Fruta” y otros poemas de PereGimferrer. Su poesía juvenil anticipa una plétora de obras literarias y fílmicas españolas querecurren a un arte técnicamente reproducido (en términos de Walter Benjamin) –específicamentelos discos del jazz y el cine negro clásico– para modelizar sujetos y acciones antitéticos alas tendencias fascistas de la historia. La modelización de nuevos sujetos se logra gracias a unaidentificación afectiva (lo que Asensi llama afepto) facilitada por una experiencia no cronológicadel tiempo asociada con el cine. Esta poesía transmite un modelo del mundo preocupado conel subalterno histórico luchando por encontrar su voz.
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Mérida Jiménez, Rafael. „Tres poemas amadisianos de Pere Gimferrer, José Manuel Lucía Megías y Luis Alberto de Cuenca“. Tirant: Butlletí informatiu i bibliogràfic de literatura de cavalleries, Nr. 23 (13.12.2020): 325. http://dx.doi.org/10.7203/tirant.23.19192.
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Análisis literario de las representaciones de Urganda la Desconocida en textos poéticos de Luis Alberto de Cuenca,Pere Gimferrer y José Manuel Lucía Megías, publicados a partir de 1985. La Desconocida es uno de los seres sobrenaturales más originales de las letras hispánicas. El sincretismo que revelan sus orígenes sufrió una profunda revisióna a largo del Amadís de Gaula, de Garci Rodríguez de Montalvo, factor que redundó en su importancia en el imaginario literario del siglo XVI. De la mano de tres de los poetas que mejor conocen la tradición literaria del Medioevo,se valorarán las significaciones éticas y estéticas de esta insólita resurrección poética, muy diferente en cada uno delos autores.
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Mérida Jiménez, Rafael. „Tres poemas amadisianos de Pere Gimferrer, José Manuel Lucía Megías y Luis Alberto de Cuenca“. Tirant: Butlletí informatiu i bibliogràfic de literatura de cavalleries, Nr. 23 (13.12.2020): 325. http://dx.doi.org/10.7203/titant.23.19192.
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Análisis literario de las representaciones de Urganda la Desconocida en textos poéticos de Luis Alberto de Cuenca,Pere Gimferrer y José Manuel Lucía Megías, publicados a partir de 1985. La Desconocida es uno de los seres sobrenaturales más originales de las letras hispánicas. El sincretismo que revelan sus orígenes sufrió una profunda revisióna a largo del Amadís de Gaula, de Garci Rodríguez de Montalvo, factor que redundó en su importancia en el imaginario literario del siglo XVI. De la mano de tres de los poetas que mejor conocen la tradición literaria del Medioevo,se valorarán las significaciones éticas y estéticas de esta insólita resurrección poética, muy diferente en cada uno delos autores.
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Woźniak-Czech, Ewelina. „Literackie inscenizacje Georges’a Pereca“. Przestrzenie Teorii, Nr. 27 (15.12.2017): 227–44. http://dx.doi.org/10.14746/pt.2017.27.16.
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The purpose of this sketch to present Georges Perec’s work in the context of drama. As Perec wrote just one play for the theater, it’s hard to call him a dramatist. However, it is easy to see that all the literary tricks he uses in his works are a part of a well-thought-out game. The author of Life a User’s Manual employs and interweaves various literary conventions, prompts dialogue between his own works and draws the reader into the very center of his tricks, nuances and simulations. Perec’s writing could be deemed a pure act of dramatization, where the author himself, to some extent, takes on the role of director, making his audience not so much the recipients of his texts but the actors performing them.
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Betancourt, Manuel. „Toward a Nonfiction Cinema of Audience Accountability“. Film Quarterly 75, Nr. 3 (2022): 76–79. http://dx.doi.org/10.1525/fq.2022.75.3.76.
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FQ columnist Manuel Betancourt muses on the difference between responsibility and accountability in the context of nonfiction cinema’s impulse towards and history of speaking up and back to power. In keeping with his preference for poetic nonfiction over traditional documentary, he considers recent Latin American documentaries that fight against narrative rules in order ask more of their audience. He suggests that filmmakers such as Jonathan Perel, whose Corporate Accountability (2021) he discusses at length, extend this notion of accountability not only to their subjects but to their audience through untraditional approaches that force viewers to sit with their discomfort and actively engage with the images before them.
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Montoya Abad, Brauli. „Coneixement i conreu de la Lingüística General als Països Catalans (1857-1937)“. Zeitschrift für Katalanistik 3 (01.07.1990): 103–15. http://dx.doi.org/10.46586/zfk.1990.103-115.
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This article tries to describe the achievements of general linguistics within Catalan culture from the mid-19th to the middle of the 20th century. The main linguistic directions that manifested themselves in the Catalan countries during this period and their main authors are the following: comparative linguistics with Lluís Nicolau d'Olwer, idealism with Manuel de Montoliu and structuralism with Ricard Aragó. The German influence is particularly present in the first two directions mentioned. During this time, the work of Pere Barnils on experimental phonetics as well as that of Antoni M. Alcover on dialectology and Alexandre Galí on didactics of syntax emerged.
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Few, Martha B. „Reviews of Books:Elites, poder local y regimen colonial: El cabildo y los regidores de Santiago de Guatemala 1700-1787 Jose Manuel Santos Perez“. American Historical Review 108, Nr. 4 (Oktober 2003): 1191–92. http://dx.doi.org/10.1086/529884.
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Garcia Oliva, J., und S. Canamares Arriba. „Sentencia del Tribunal Constitucional 51/2011: Spanish Constitutional Court (Full Chamber): Pascual Sala Sanchez (President), Eugeni Gay Montalvo, Javier Delgado Barrio, Elisa Perez Vera, Ramon Rodriguez Arribas, Manuel Aragon Reyes, Pablo Perez Tremps, Francisco Jose Hernando Santiago, Adela Asua Batarrita, Luis Ignacio Ortega Alvarez and Francisco Perez de los Cobos Orihuel JJ: 14 April 2011“. Oxford Journal of Law and Religion 1, Nr. 1 (05.01.2012): 296. http://dx.doi.org/10.1093/ojlr/rwr013.
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Clark, Samuel. „Manuel Perez-Garcia, Blood, Land and Power: The Rise and Fall of the Spanish Nobility and Lineages in the Early Modern Period“. Canadian Journal of History 57, Nr. 1 (01.03.2022): 123–25. http://dx.doi.org/10.3138/cjh-57-1-2021-0059.
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Rodríguez, Ángel. „Globalización y Estado del bienestar: debates actuales en Europa y Asia. Una presentación“. Estudios de Deusto 66, Nr. 1 (03.08.2018): 15–20. http://dx.doi.org/10.18543/ed-66(1)-2018pp15-20.
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Jean Monnet, one of the founding fathers of the European Union, once said that “Nothing is possible without men, but nothing lasts without institutions”. This is also true for academic initiatives. After more than sixty years of a generalized mutual indifference (although with some notable exceptions) between legal academics from The Philippines and Spain, new links were re-established in the early years of the present decade. The reflourishing was the result of the passionate efforts of two remarkable scholars from both countries, namely professor José Manuel Torres Perea, a promising lecturer of Civil Law at the University of Málaga (UMA), Spain, and the renowned and highly praised maestro of several generations of Filipino jurists, professor Ruben Balane. Recibido: 20 junio 2018Aceptado: 25 junio 2018Publicación en línea: 03 agosto 2018
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Ceballos Viro, Álvaro. „Leer con los republicanos radicales“. Cultura de la República. Revista de Análisis Crítico (CRRAC), Nr. 5 (27.12.2021): 108–21. http://dx.doi.org/10.15366/crrac2021.5.006.
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El presente trabajo comienza enfatizando la pluralidad y la variedad de la cultura republicana española a principios del siglo XX. Asumiendo el planteamiento de historiadores políticos y sociales como Ángel Duarte, Pere Gabriel o Manuel Morales Muñoz, se proyecta la cultura republicana en el eje diastrático, identificando, junto a un republicanismo de prosapia intelectual, otro de extracción popular o «plebeya», que dio un respaldo masivo a los líderes llamados «radicales». Subsiguientemente se propone el análisis de varios textos literarios vinculados a ese republicanismo radical, y se aportan indicios sobre el modo en que su interpretación y su uso eran presumiblemente orientados por el contexto periodístico en el que esos textos vieron originalmente la luz.
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Hang, Xing. „Global History and New Polycentric Approaches: Europe, Asia and the Americas in a World Network System, edited by Manuel Perez Garcia and Lucio de Sousa“. Asian Review of World Histories 7, Nr. 1-2 (23.01.2019): 278–81. http://dx.doi.org/10.1163/22879811-12340057.
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Kung, Ling-Wei. „Manuel Perez-Garcia. Global History with Chinese Characteristics: Autocratic States along the Silk Road in the Decline of the Spanish and Qing Empires 1680–1796“. China and Asia 4, Nr. 2 (05.01.2023): 325–28. http://dx.doi.org/10.1163/2589465x-04020007.
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Bianco, Serena. „EL ERROR DE TRADUCCIÓN EN EL DOBLAJE: EL CASO DE LA PELÍCULA REINAS DE MANUEL GÓMEZ PEREIRA DOBLADA AL ITALIANO“. Transfer 12, Nr. 1-2 (18.01.2022): 114–28. http://dx.doi.org/10.1344/transfer.2017.12.114-128.
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El impacto tecnológico y el enorme valor social y cultural con los quecuenta el ámbito de la traducción audiovisual es el punto de partida deuna investigación sobre el doblaje, los problemas que este plantean y suserrores. De hecho, el avance tecnológico en el mundo de los medios decomunicación, junto con las exigencias cada vez mayores de losespectadores, abre una reflexión sobre esta modalidad de TAV y sucalidad en términos de imagen, sincronización y sobre todo esmerolingüístico.Después de una descripción general de las características y dificultadesque presenta el doblaje, la modalidad de TAV más usada en Europa juntocon la subtitulación, ilustraremos a través de un análisis crítico de laversión doblada al italiano de la película Reinas (2005), de Manuel GómezPereira, los obstáculos que pueden influir en la calidad final del producto,y los errores de traducción que surgen de estos. Demostraremos que lamayoría de ellos no representan verdaderos problemas, sino que son elresultado de la negligencia y la pereza por parte de los ajustadores, queintentan alcanzar un perfecto sincronismo labial sin tener en cuenta lasnecesidades de una comunicación real.
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Aguilar Ruiz, Manuel José. „Reseña de M.ª Carme Jonyent Figueras y Pere Comellas Casanova: Antropología lingüística. Madrid: Editorial Síntesis (2019), 235 páginas. ISBN: 978-84-9171-431-6.“ Normas 10, Nr. 1 (26.12.2020): 93. http://dx.doi.org/10.7203/normas.v10i1.18148.
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El objetivo que pretende el breve manual aquí reseñado, como indica su misma «Introducción», es el de ofrecer una aproximación a la disciplina que conocemos como antropología lingüística con la que, partiendo de los procedimientos y métodos clásicos de estudio de esta disciplina, se entienda cómo es posible establecer una relación entre lenguas y culturas (bajo concepciones tradicionales o, según las perspectivas más actuales, entre lo lingüístico y lo extralingüístico). De este modo, el libro pretende ser «una introducción al fascinante mundo de las lenguas y sus relaciones con las culturas, tan distintas y al mismo tiempo tan iguales en la medida en que se trata de manifestaciones de una misma cara, la humana.
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Aguilar Ruiz, Manuel José. „Reseña de M.ª Carme Jonyent Figueras y Pere Comellas Casanova: Antropología lingüística. Madrid: Editorial Síntesis (2019), 235 páginas. ISBN: 978-84-9171-431-6.“ Normas 10, Nr. 1 (26.12.2020): 93. http://dx.doi.org/10.7203/normas.v10i1.18148.
Der volle Inhalt der QuelleAnnotation:
El objetivo que pretende el breve manual aquí reseñado, como indica su misma «Introducción», es el de ofrecer una aproximación a la disciplina que conocemos como antropología lingüística con la que, partiendo de los procedimientos y métodos clásicos de estudio de esta disciplina, se entienda cómo es posible establecer una relación entre lenguas y culturas (bajo concepciones tradicionales o, según las perspectivas más actuales, entre lo lingüístico y lo extralingüístico). De este modo, el libro pretende ser «una introducción al fascinante mundo de las lenguas y sus relaciones con las culturas, tan distintas y al mismo tiempo tan iguales en la medida en que se trata de manifestaciones de una misma cara, la humana.
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Dela Cruz, Luisito, und Moses Aaron Angeles. „Towards stronger local government and educational institutions in climate change impact mitigation: A policy paper on fiscal sustainability on climate change“. Bedan Research Journal 7, Nr. 1 (30.04.2022): 229–54. http://dx.doi.org/10.58870/berj.v7i1.39.
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Through a careful analysis of official government documents such as national statutes, national agency memorandum orders, policy directives reports, and national and local plans, among others, pertinent to the Philippine Government's response to climate change mitigation and adaptation, the paper elucidated the policy directions of the country concerning climate change response. Aimed at proposing recommendations to enhance the current legal, organizational, and fiscal frameworks of the Philippine Government in its efforts to mainstream its climate change strategy, the paper identified some of the gaps and possible areas of improvement in the standing legal and structural constellations of policies employed in the country. It has been found by the research that though there have been actions related to the international mandate of promoting sustainable development, there are still areas that can be reformed and revisited if the government programs and institutions are to remain in fidelity to the commitments of the Philippines to combat the impacts and mitigate the effects of climate change. As the title suggests, the paper offers policy directions to strengthen government and academic institutions to better respond to this daunting challenge.References2013 Typhoon Haiyan: Facts, FAQs, and how to help. (n.d.). World vision. https://www.worldvision.org/disaster-relief-news-stories/2013-typhoon-haiyan-facts.Asian Disaster Reduction Center. (n.d.). Information on disaster risk reduction of member countries. https://www.adrc.asia/nationinformation.php?NationCode=608&Lang=en.Asian Development Bank. (2012). Addressing migration and climate change in Asia and the Pacific: Final report. ADB.Blair, H. (2000). Participation and accountability in the periphery: Democratic local governance in six countries. World Development 28(1). 21-39.Brillantes, A. & Montes, R. (2007). Federalism: Logical step after devolution? Philippine Journal of Public Administration 51(1-4). 1-32.Brillantes, A. (1987). Decentralization in the Philippines: An overview. Philippine Journal of Public Administration, 31 (2): 131-148.Brillantes, A. (1998). Decentralized democratic governance under the local government code: A governmental perspective. Philippine Journal of Public Administration, 32(1&2): 38-57.Brown, K. (2012). Typhoon Pablo batters ‘typhoon-free’ Mindanao. The Asia Foundation. https://asiafoundation.org/2012/ 12/19/typhoon-pablo-batters-typhoon-free-mindanao/.Capuno, J. (2019). Tugs of war: Local governments, national government. Public Policy Journal, 16 & 17: 98-116.Cheema, S. & Rondinelli, D. (2007). Decentralizing governance: Emerging concepts and practices. Brookings Institution Press.Dorotan, E. & Carizo, J. (2014). Issues and critical actions in local governance. Galing Pook Foundation.Hannah, R. (2014). Climate change and human development. Zed Books Ltd.Griggs, G. (2017). Coasts in crisis: A global challenge. University of California Press.Jha, A. & Geddes, Z. (2013). Strong, safe, and resilient: A strategic policy guide for disaster risk management in East Asia and the Pacific. The World Bank.Local Government Academy of the Philippines. (2013). User’s manual for LGUs: Guidebook for the preparation of LCCAP. Fabi’s Enterprises.Manila Observatory for the Congressional Commission on Science and Technology and Engineering. (2010). COMSTE Technical primer on climate change in the Philippines conference engineering resilience, confronting risk beyond adaptation. Sofitel ManilaMayon mud buries 100 in Bicol amid ‘Reming’ fury. (2006, Nov. 30). GMA News Online. https://www.gmanetwork.com/news/news/nation/22465/mayon-mud-buries-100-in-bicol-amid-remingfury/story/.National Climate Change Commission. (2021). 2020 Accomplishment Report: Adapting for a sustainable future.National Climate Change Commission. (2011). National climate change action plan.National Climate Change Commission. (2019). The Philippine national climate change action plan.NDCC: Typhoon ‘Frank’ damage estimate now at P 10B. (2008, July 1). GMA News Online. https://www.gmanetwork.com/news/news/nation/104407/ndcc-typhoon-frank-damage-estimate-now-atp10b/story/.Perez, R. (2017). Assessment of vulnerability and adaptation to climate change in the Philippines coastal resources sector. Natural Disaster Reduction Branch – PAGASA.Remembering Milenyo’s wrath in 2006. (2014, July 15). Philippine Star. https://www.philstar.com/news-commentary/2014/07/15/1346515/remembering-milenyos-wrath-2006.Republic Act 9729, An act mainstreaming climate change into government policy formulations, establishing the framework strategy and program on climate change, creating for this purpose the climate change commission, and other purposes (2009). https://www.officialgazette.gov.ph/2009/10/23/republic-act-no- 9729/.Republic Act 10174, An act establishing the people’s survival fund to provide long-term finance streams to enable the government to effectively address the problem of climate change, amending for the purpose Republic Act 9729, otherwise known as the 'Climate Change Act of 2009', and for other purposes (2012). https://www.officialgazette.gov.ph/2012/08/16/republic-act-no-10174/.Republic Act 10121, An act strengthening the Philippine Disaster Risk Reduction and Management System, providing for the National Disaster Risk Reduction and Management framework and institutionalizing the National Disaster Risk Reduction and Management Plan, appropriating funds therefore and for other purposes (2010). https://www.officialgazette.gov.ph/2010/05/27/republic-act-no-10121/.Republic Act 7160, An Act for a Local Government Code of 1991 (1991). https://www.officialgazette.gov.ph/1991/10/10/republic-act-no-7160/.Walker, R. & Mason, W. (2015). Climate change adaptation for health and social services. CSIRO Publishing.
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Martín-Carrasco, Manuel, und Manuel Gonçalves-Pereira. „S18: Newcomers to euthanasia and assisted suicide: challenges for Psychogeriatrics with a focus on Spain and Portugal“. International Psychogeriatrics 35, S1 (Dezember 2023): 52–53. http://dx.doi.org/10.1017/s1041610223002259.
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Euthanasia or assisted suicide are now legal in several European countries. Spain has approved related legislation in 2022, and in Portugal the subject is currently under debate after preliminary ratification. This remains a controversial topic, raising passionate discussions that sometimes hamper the need to consider, in depth, the ethical, clinical, and operational difficulties of processes of this type. Older age people do not necessarily lose their autonomy with age, nor should they lose their right to decide on euthanasia or assisted suicide whenever the jurisdiction allows it. However, there is a growing concern of older people being coerced into decisions about ending their lives, not least due to their own fears of becoming a burden both for their families and the society. Manuel Martín-Carrasco will analyze how ageism can influence or model a wish to die in elderly people, especially those living with greater physical and/or mental disability. The so-called rational suicide focuses on the possibility that a healthy subject eventually decides to end his own life as a reflex of a free decision, and not within the context of a mental illness. Manuel Sánchez-Perez will discuss how difficulties in assessing the rationality of suicidal ideation include its dimensional character, together with the evidence that rationality is not always absent in depression and that the absence of depression does not imply rationality. Next, Lia Fernandes will provide an overview of years of public and parliamentary debates on euthanasia and physician-assisted suicide in Portugal. She will focus on issues regarding the exact role of psychiatrists (old age psychiatrists in particular) in the decision process, as proposed by the recently approved legislation. Finally, Javier Olivera will provide a brief overview of the recent implementation of legal access to euthanasia in Spain. A discussion of several controversial aspects of the operationalization of such a complex process will follow, including those related with conscientious objection.
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Castillo Granada, Álvaro. „Los Sonetos“. LA PALABRA, Nr. 22 (10.09.2013): 127. http://dx.doi.org/10.19053/01218530.2022.
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Para Carlos Ojeda GómezNadie tiene por qué saberlo. Además no importa. Soy el primerejemplar que llegó a las manos de Manuel Mujica Láinez de su traducción de los Sonetos de William Shakespeare, publicados por la Editorial Losada. No tradujo los 154 sino los 49 que más le gustaban. Al menos eso dijo. En el fondo creo que le dio pereza traducirlos todos. Traducir es un trabajo doble: volverse otro escritor y seguir siendo un escritor. Bueno, con la palabra “doble”creo que todo está dicho. Ese es el problema de los libros que han viajado mucho y pasan por demasiadas manos, temporal o definitivamente. Aunque el hecho de que yo esté aquí, en esta hoja de papel que no hace parte de mi cuerpo y que, con toda seguridad, terminará en la basura, implica que no hay algo definitivo para un libro, en el sentido estricto del término. Por fortuna en esta librería siempre hay un mataburros a mano: “¡Oye, Diccionarioooo!, dime rápido el significado de la palabra definitivo”.
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Hughey, Jim. „Rif Winfield, John Tredrea, Enrique Garcia-Torralba Perez, and Manuel Blasco Felip, Spanish Warships in the Age of Sail, 1700-1860. Design, Construction, Careers and Fates by Jim Hughey“. Northern Mariner / Le marin du nord 33, Nr. 3-4 (28.06.2024): 586–88. http://dx.doi.org/10.25071/2561-5467.1228.
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Residentes, Residentes. „Gastroenterología“. Acta Médica Colombiana 43, Nr. 2S (01.10.2018): 85–95. http://dx.doi.org/10.36104/amc.2018.1396.
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GA-1 MIOSITIS PERIORBITARIA COMO MANIFESTACIÓN EXTRAINTESTINAL DE LA ENFERMEDAD DE CROHN (AGUDELO CARLOS, PEREZ MARÍA, LUNA FREDY, MILLÁN HENRY)
GA-2 ASCITIS QUILOSA, RETO DIAGNOSTICO Y TERAPEUTICO (OSWALDO E. AGUILAR MOLINA, CHRISTIAN A. MONTAÑO, JAIME HOLGUIN)
GA-3 SPRUE TROPICAL, NUEVA CARA DE UNA VIEJA ENFERMEDAD (OSWALDO E. AGUILAR MOLINA, CHRISTIAN A. MONTAÑO BRANCA, JAIME HOLGUÍN)
GA-4 DESPUÉS DE 100 AÑOS DE HISTORIA SÍNDROME DE PLUMMERVINSON (SANDOVAL JENNIFER, GONZÁLEZ ÁLVARO, PINTO NATALIE, RUEDA SANDRA, ARDILA MANUEL)
GA-5 ENFISEMA SUBCUTANEO MASIVO UNA COMPLICACION INUSUAL POST-COLANGIOPANCREATOGRAFIA RETROGRADA ENDOSCOPICA (ALZA JHONGERT, ARENAS MARÍA, BARBOSA JENNY, BRICEÑO BIBIANA, CHACÓN DANIELA, CORTÉS MARÍA, BARRERA EDGAR)
GA-6 RECIDIVA DE COLANGITIS ESCLEROSANTE PRIMARIA EN POSTTRASPLANTE HEPATICO (ALZA JHONGERT, ROJAS WILLIAM, RUIZ MARÍA, SANTOS CARMEN, TORRES NICOLÁS, VIVAS ALEJANDRA, BARRERA EDGAR)
GA-7 RETENCIÓN DE CÁPSULA ENDOSCÓPICA POR ILEITIS (RAMÍREZ SOLARTE ÁNGELA VIVÍAN, RESTREPO HOLGUÍN DANIEL FRANCISCO, REVELO JIMÉNEZ FRANCISCO)
GA-8 HEMORRAGIA DE VÍAS DIGESTIVAS BAJAS COMO COMPLICACIÓN INFECCIOSA (CASTAÑEDA CAMACHO HÉCTOR ANDRES, TORRES BUSTAMANTE ANGELA MARÍA)
GA-9 CARACTERIZACIÓN DE LOS PACIENTES CON DIAGNÓSTICO DE COLITIS POR CLOSTRIDIUM DIFFICILE EN UN CENTRO DE BOGOTÁ DURANTE LOS AÑOS 2016 A 2018 (PÉREZ MARÍA ALEJANDRA, ZULUAGA JUAN DAVID, MILLÁN HENRY AUGUSTO, SUAREZ DAVID, LUNA FREDY ANDRÉS, DUARTE LUISA, NOREÑA IVÁN)
GA-10 HEPATITIS AUTOINMUNE CON PRESENTACION ATIPICA (ACUÑA JUAN, MORA JAVIER, LEGRO GIOVANNI, NAVARRETE LINDA, CUERVO JESSICA)
GA-11 APLICABILIDAD DE LOS CRITERIOS DE SWANSEA PARA DIAGNÓSTICO DE HÍGADO GRASO AGUDO DEL EMBARAZO (HGAE). ESTUDIO DE COHORTE RETROSPECTIVO (ROJAS-SUAREZ JOSÉ, PÉREZ-RAMÓN HUGO, LORA-ANDOSILLA MARIO, RODRÍGUEZ-YÁNEZ TOMAS, DUEÑAS-CASTELL CARMELO)
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Nelken, David. „Law in Many Societies: A Reader, edited by Lawrence M Friedman, Rogelio Perez Perdomo and Manuel Gomez [Stanford Law Books, Stanford, CA, 2011, x + 322pp, ISBN 0804763747, £24.65 (p/bk)] [check p/h/bk prices]“. International and Comparative Law Quarterly 61, Nr. 4 (Oktober 2012): 1017–22. http://dx.doi.org/10.1017/s0020589312000383.
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Marpika, Lily, Helni Anggraini, Anur Rohmin und Siti Amallia. „Hubungan Pengetahuan, Sikap dan Pendidikan Ibu dengan Pemberian ASI Eksklusif pada Ibu yang Memiliki Bayi Usia Lebih dari 6 Bulan di Wilayah Kerja Puskesmas Gandus Tahun 2021“. Jurnal Ilmiah Universitas Batanghari Jambi 23, Nr. 2 (26.07.2023): 2073. http://dx.doi.org/10.33087/jiubj.v23i2.3234.
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Exclusive breastfeeding is the best food given to babies during the age of 0-6 months without being interspersed with other additional food. However, in reality, there are still many breastfeeding mothers who do not provide exclusive breastfeeding to their babies due to various factors. In Indonesia, mothers who exclusively breastfeed their babies during the current month are still low, which is 2% of the total number of mothers who give birth. The behavior of breastfeeding mothers is based on Lawrence Green's (1980) behavioral theory, namely predisposing factors (knowledge, attitudes, education level, and work), enabling factors (family economic level), and reinforcing factors (family role). This study was conducted to see the various factors associated with low exclusive breastfeeding in infants in Gandus District. This study used descriptive analytic method with cross sectional approach, where the sample was 100 breastfeeding mothers. Sampling using Random Sampling method, namely Proportioned Stratified Random Sampling. The instrument in this study used a questionnaire. Data processing using manual system was done by univariate and bivariate analysis with Chi-Square test with level of sgnificant (alpha) 0.05. From the results of the study it is known that the value of x2 count is greater than x2 table for work (4.06> 2.71), so there is a significant relationship between work and low exclusive breastfeeding. While the x2 value is smaller than the x2 table (knowledge (1.43 < 2.71), attitude (0.34 < 2.71), education level (0.10 < 4.61), family economic level (0.44 < 2.71), and family peren (0.58 < 2.71), so there is no significant relationship with the low exclusive breastfeeding in infants. The suggestion from this study is that all parties involved in exclusive breastfeeding in infants can make various efforts to increase knowledge and awareness that are adjusted to all the resources available in the area.
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Residente, Residente. „Reumatología“. Acta Médica Colombiana 43, Nr. 2S (24.06.2019): 240–75. http://dx.doi.org/10.36104/amc.2018.1406.
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R-1 NEUROPATÍA CRANEANA MÚLTIPLE COMO PRIMERA MANIFESTACIÓN DE SARCOIDOSIS - REPORTE DE CASO. (AGUDELO CARLOS, CORTÉS CAMILO)
R-2 DISECCIÓN CAROTÍDEA COMO CAUSA DE ATAQUE CEREBROVASCULAR EN PACIENTE JÓVEN CON SÍNDROME ANTIFOSFOLÍPIDO SECUNDARIO A LUPUS ERITEMATOSO SISTÉMICO (RICAURTE ANDRÉS, OCAMPO MARIA ISABEL, PENAGOS LAURA CONSTANZA, CAICEDO TOMÁS)
R-3 APROXIMACIÓN DIAGNÓSTICA EN AMILOIDOSIS SISTÉMICA (LEAL JANETH, QUEVEDO HENRY, JIMÉNEZ ANA, MONSALVE MÓNICA, JARAMILLO DANI)
R-4 LECCIONES APRENDIDAS EN EL DIAGNÓSTICO DE UN PACIENTE CON ENFERMEDAD DE STILL DEL ADULTO (RUMBO JOSÉ, RICAURTE ANDRÉS, TASSINARI STEFANO, CARRERO LAURA, PATIÑO LUISA, BUSTOS MARLON)
R-5 DIAGNOSTICO DIFERENCIAL DE TAPONAMIENTO CARDIACO APROPÓSITO DE UN CASO DE LUPUS DE INICIO TARDÍO (POVEDA GUSTAVO, ALZA JHONGERT, GARCÍA DIANA, ALZA LYZINHAWER)
R-6 ANEURISMA DE AORTA ABDOMINAL EN PACIENTE CON SOSPECHA DE SÍNDROME DE MARFÁN: REPORTE DE CASO EN EL HOSPITAL SANTA CLARA BOGOTÁ - COLOMBIA (ROMERO SANTIAGO, ROSADO KATIANA)
R-7 VASCULITIS OCULAR SECUNDARIO A GRANULOMATOSIS CON POLIANGITIS ANCAS NEGATIVOS (BEDOYA VANESSA, OSORIO LUIS M., SUÁREZ NATALIA A., RUEDA JORGE M., Y LIBREROS DIANA M)
R-8 ENCEFALITIS LIMBICA ASOCIADA A LUPUS ERITEMATOSO SISTÉMICO (SIERRA-MERLANO RITA-M, SEGOVIA-FUENTES JAVIER, RAMÍREZBARRANCO ROSANGELA, ÁLVAREZ-CASTRO MARÍA-FERNANDA)
R-9 NEUMONIA POR PNEUMOCYSTIS JIROVECII EN ARTRITIS REUMATOIDE (SIERRA-MERLANO RITA M, ARAUJO-OROZCO KARINA, RAMÍREZBARRANCO ROSANGELA)
R-10 MIOCARDIOPATIA INFILTRATIVA POR ANTIMALARICOS EN PACIENTE CON LUPUS ERITEMATOSO SISTÉMICO (GAMBA FERNANDO, GRISALES NATALIA, ORLAS CLAUDIA, ESPINOSA NATALIA, ESCARRIA DIANA, BACCA JOHANA, VEGA DAVID, GONZÁLEZ HERMAN, CUELLO HAROLD. URREA JUAN KARLO)
R-11 PSEUDOTUMOR PULMONAR COMO DEBUT CLÍNICO DE GRANULOMATOSIS CON POLIANGITIS (RINCÓN ÁLVAREZ EMILY, CONDE-CAMACHO RAFAEL E, JIMÉNEZ-CANIZALES CARLOS EDUARDO, PUENTES MARÍA ELSY, DOMÍNGUEZ JUAN DIEGO)
R-12 ENFERMEDAD RELACIONADA CON IGG4: ¿ES EL RITUXIMAB LA MEJOR ESTRATEGIA TERAPÉUTICA? RESULTADOS DE UNA REVISIÓN SISTEMÁTICA (DÍAZ-CORONADO JUAN C, ROJAS-VILLARRAGA ADRIANA, HERNANDEZ-PARRA DEICY, PEREZ-ESTRADA PAULA, BETANCURVÁSQUEZ LAURA, GONZALEZ-HURTADO DANIEL, ARANGO-ISAZADANIELA, CARMONA-SAMUEL)
R-13 LA IL-6 ES UN FACTOR CENTRAL EN LA ESCLEROSIS SISTÉMICA (ROJAS MANUEL, RODRÍGUEZ YHOJAN, PACHECO YOVANA, MONSALVE DIANA M., ACOSTA-AMPUDIA YENY, MÓNICA RODRÍGUEZ-JIMENEZ, RUBÉN D. MANTILLA, RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-14 DE LA ECOLOGÍA AUTOINMUNE AL DESARROLLO DE POLIAUTOINMUNIDAD (ROJAS MANUEL, RODRÍGUEZ YHOJAN, PACHECO YOVANA, MONSALVE DIANA M., ACOSTA-AMPUDIA YENY, RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-15 AUTOINMUNIDAD TIROIDEA EN INDIVIDUOS EUTIROIDEOS (RODRÍGUEZ YHOJAN, MONSALVE DIANA M., PACHECO YOVANA, ACOSTA-AMPUDIA YENY, ROJAS MANUEL, RODRÍGUEZ-JIMÉNEZ MÓNICA, MOLANO-GONZÁLEZ NICOLAS, RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-16 POLIAUTOINMUNIDAD TIROIDEA EN EL SINDROME DE SJÖGREN (RESTREPO PAULA, BAYONA NATALIA, LEON KELLY, RODRÍGUEZ YHOJAN, CASTELLANOS LAURA, ZAPATA ESTEFANÍA, SÁNCHEZ JANNETH, ROJAS MANUEL, RAMÍREZ CAROLINA, MONSALVE DIANA, PACHECO YOVANA, ACOSTA YENY, RODRÍGUEZ MÓNICA, MOLANO NICOLÁS, ANAYA JUAN-MANUEL)
R-17 HIPERFERRITINEMIA y SINDROME FEBRIL PROLONGADO (CASTAÑEDA CAMACHO HÉCTOR ANDRES, PINILLA QUINTERO LADY SAMARA, MELO GUARÍN ASTRID ROCÍO, HIGUERA COBOS JUAN DIEGO)
R-18 SÍNDROME DE DEVIC (PEDRAZA MAURICIO, NAVARRETE LINDA, SOLÓRZANO CARLOS, SUPELANO MARIO, MÉNDEZ ALEJANDRO)
R-19 DE LA ARTRITIS REUMATOIDE AL HIPERCORTISOLISMO EXÓGENO (FERNÁNDEZ JORGE, CLAVIJO FAIR, SILVA O.)
R-20 VASCULITIS PRIMARIA SISTÉMICA COMO CAUSA DE FIEBRE DE ORIGEN DESCONOCIDO (FOD): REPORTE DE UN CASO y ENFOQUE PARA EL CLÍNICO (RUIZ TALERO PAULA ANDREA, VALENCIA-MEJÍA MARGARITA ROSA, RONDÓN-CARVAJAL JULIÁN FELIPE, CONTRERAS KATEIR MARIE)
R-21 SÍNDROME ESCLERODERMIFORME COMO MANIFESTACIÓN PARANEOPLÁSICA DE CÁNCER DE PRÓSTATA (RONDÓN-CARVAJAL JULIÁN FELIPE, REYNA-CARRASCO ÓSCAR ANDRÉS, CUÉLLAR-RÍOS ISABEL CRISTINA, MUÑOZ-VELANDIA OSCAR MAURICIO)
R-22 OLIGOARTRITIS AGUDA REACTIVA y COMPROMISO EXTRAARTICULAR (CASTAÑEDA CAMACHO HÉCTOR ANDRÉS, TORRES BUSTAMANTE ANGELA MARÍA, TORRES BUSTAMANTE MARIANA)
R-23 EMBOLIA PULMONAR COMO PRIMERA MANIFESTACIÓN EN PACIENTE CON SÍNDROME DE KIKUCHI FUJIMOTO (RUEDA GALVIS MYRIAM, BAUTISTA MIER HEIDER)
R-24 MIOSITIS POR CUERPOS DE INCLUSION (HURTADO YESID; CAMPY JUAN; CORTÉS CAMILO)
R-25 DISFUNCIÓN VENTRICULAR IZQUIERDA SECUNDARIA A REACTIVACIÓN DE LUPUS ERITEMATOSO SISTÉMICO (BUSTOS-CLARO MARLON MAURICIO, GARCIA-CONSUEGRA ELIAS ALBERTO, MOLINA-PIMIENTA LUISANA, RAMÍREZ-MESÍAS DIANA CRISTINA.)
R-26 DEDO AZUL COMO MANIFESTACIÓN DE UN CASO GRAVE DE SÍNDROME DE SOBREPOSICIÓN (ALARCÓN-ROBLES PILAR, SALGADO-SÁNCHEZ JUAN CAMILO, MOLINA-PIMIENTA LUISANA)
R-27 ENCEFALOMIELITIS DISEMINADA AGUDA COMO MANIFESTACIÓN PRIMARIA DE LUPUS ERITEMATOSO SISTÉMICO (GUTIÉRREZ CAROL, MORA SERGIO, TOSCANO ANDRÉS)
R-28 BIOPSIA RENAL CONSECUTIVA EN UNA COHORTE DE PACIENTES CON NEFRITIS LÚPICA DEL CARIBE COLOMBIANO (AROCA GUSTAVO, MENDOZA-JAIMES JACKELINE, GONZÁLEZTORRES HENRY, DOMÍNGUEZ-VARGAS ALEX,MARTINEZ ÁLVARO, CADENA BONFANTI ANDRÉS)
R-29 NEUMOMEDIASTINO ESPONTANEO y DERMATOMIOSITIS (SUPELANO MARIO, ENRIQUE PRIETO, AGATÓN CATALINA, NAVARRETE LINDA, CUINEME SANDRA)
R-30 ENCEFALOPATIA POSTERIOR REVERSIBLE SECUNDARIO A NEUROLUPUS UN DIAGNÓSTICO INUSUAL (MORA JAVIER MAURICIO, OVIEDO PABLO, CABRA ANDREA, FUENTES CARLOS, PRIETO JAVIER, CUERVO JESSICA, FLECHAS JOHN)
R-31 INTOXICACION POR LEVAMIZOL: UNA CAUSA DE VASCULOPATIA EN CONSUMIDORES DE COCAINA (CASTELLANOS-DE LA HOZ JUAN, NARANJO JULIÁN, AGUDELO CARLOS, ARAGÓN DIANA)
R-32 SINDROME DE FELTY y PIODERMA (MARTÍNEZ DIEGO, ECHEVERRY TATIANA, RIAÑO CATALINA, ALVARADO LINA, VILLANUEVA JULIANA)
R-33 PANUVEÍTIS EN EL CONTEXTO DEL SÍNDROME DE VOGTKOyANAGI-HARADA (ÁLVAREZ-PERDOMO LUIS CARLOS, PERDOMO-QUINTERO DANIELA, GIRÓN- CÁRDENAS CAMILA, GONZALEZ- AVILÉS CATALINA)
R-34 TAXONOMÍA DE LAS ENFERMEDADES REUMÁTICAS AUTOINMUNES BASADA EN LA POLIAUTOIMMUNIDAD (MOLANO-GONZÁLEZ NICOLAS, ROJAS MANUEL, RODRÍGUEZ YHOJAN, PACHECO YOVANA, MONSALVE DIANA M., ACOSTAAMPUDIA YENY, RODRÍGUEZ-JIMENEZ MÓNICA, MANTILLA RUBÉN D., RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-35 ENFERMEDAD DE STILL: UN RETO DIAGNÓSTICO y TERAPEÚTICO (ARDILA BÁEZ MANUEL, SANDOVAL JENNIFER, TAPIAS ELSA, BERNAL EDGAR)
R-36 HEMOGLOBINURIA PAROXÍSTICA NOCTURNA CON ESQUISTOCITOS EN EL FROTIS DE SANGRE PERIFÉRICA (ALARCÓN CLARA, ÁLVAREZ LUIS CARLOS, DOMÍNGUEZ JUAN DIEGO, ROMÁN ADRIANA, PUENTES MARÍA ELCY, JIMENEZ JAIME MARTIN)
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Martinez-Cannon, Bertha Alejandra, Enrique Soto-Perez-de-Celis, Aura A. Erazo Valle-Solis, Claudia Arce Salinas, Enrique Bargallo Rocha, Veronica Bautista Piña, Ma Guadalupe Cervantes Sanchez et al. „Abstract P3-17-05: Physicians’ attitudes and perceived barriers to adherence to national breast cancer clinical practice guidelines (BCCPG) in Mexico“. Cancer Research 82, Nr. 4_Supplement (15.02.2022): P3–17–05—P3–17–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-17-05.
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Abstract Background: Adherence to BCCPG improves clinical outcomes for patients with breast cancer. However, implementation of international BCCPG may not be feasible in low- and middle-income countries (LMICs) due to limitations in resources and personnel. A potential solution for this issue is developing national/regional guidelines considering local healthcare contexts. In Mexico, the National Consensus on Diagnosis and Treatment of Breast Cancer (known as the Colima Consensus, http://consensocancermamario.com) is considered the national BCCPG, and it is updated bi-yearly since 1994. The aim of this study was to evaluate physicians’ uptake of the Colima Consensus recommendations, and to identify barriers and attitudes that may impact adherence. Methods: A cross-sectional, 30-item survey exploring attitudes towards the Colima Consensus, as well as barriers limiting adherence to its recommendations, was e-mailed to Consensus attendees, members of the Mexican Society of Oncology, and of the Mexican Mastology Association, with answers collected over 3 weeks. Descriptive statistics, including means, medians, and standard deviations were used to analyze the participants’ sociodemographic characteristics, attitudes, and perceived barriers. X2 tests were used to evaluate associations between physicians’ characteristics/attitudes and adherence. Results: Among 1553 physicians invited to participate, 320 (21%) answered the survey, of which 25 (8%) were unaware of the Colima Consensus. Two hundred ninety-five participants completed the entire survey and were included in this analysis. Fifty-six percent were male, 65% were age 30-49, 44% practiced in Mexico City, and 8% were foreign. Regarding specialty, 26% were surgical oncologists, 14% medical oncologists, and 10% radiation oncologists. Over half of respondents (57%) worked in both public and private practice, while 19 and 23% worked only in public or private practice, respectively. Sixty-two percent had access to a multidisciplinary breast cancer team. Eighty-five percent reported using the Colima Consensus to guide clinical decision making and 77% adhered to its recommendations in most/all cases. Forty-two percent used the Colima Consensus as their only guideline reference. Surgical oncologists were more likely than medical oncologists to use the Colima Consensus as their only guideline reference (29 vs. 12%, p<0.01). The most commonly reported barriers to adherence were lack of resources (51%) and logistical issues (31%). Physicians working without a dedicated multidisciplinary breast cancer team were significantly more likely to report a lack of resources as a barrier than those with a multidisciplinary team (63 vs. 43%, p<0.01). No differences were found in other barriers according to participants’ characteristics. Regarding attitudes towards the Colima Consensus, 88% agreed/strongly agreed that it was a valuable teaching tool, 88% considered it a trustworthy source of information, and 89% believed it led to improved quality of care. Seventy-six percent of the participants agreed/strongly agreed that the Consensus’ recommendations were free of bias and 58% considered that its use led to reduced costs of care. Conclusions: Initial results of our study show high levels of adherence and positive attitudes towards the Colima Consensus, with a significant proportion of physicians using it as their main guideline reference. Lack of resources and logistical issues were the main barriers hampering implementation of recommendations, particularly for physicians working without a multidisciplinary breast cancer team. Our results highlight the relevance of local BCCPG and of multidisciplinary collaborations, and suggest a need for the creation of stratified recommendations for various healthcare settings and resources. Citation Format: Bertha Alejandra Martinez-Cannon, Enrique Soto-Perez-de-Celis, Aura A. Erazo Valle-Solis, Claudia Arce Salinas, Enrique Bargallo Rocha, Veronica Bautista Piña, Ma. Guadalupe Cervantes Sanchez, Christian Haydee Flores Balcazar, Maria del Carmen Lara Tamburrino, Ana Lluch Hernandez, Antonio Maffuz Aziz, Victor Manuel Perez Sanchez, Adela Poitevin Chacon, Efrain Salas Gonzalez, Laura Torrecillas Torres, Vicente Valero, Yolanda Villaseñor Navarro, Jesus Cardenas Sanchez. Physicians’ attitudes and perceived barriers to adherence to national breast cancer clinical practice guidelines (BCCPG) in Mexico [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-17-05.
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Van Ausdal, Shawn, Jackeline Velazco Portocarrero, Christine Fertig, Ricard Soto, Gabriel Jover, Inmaculada Villa, Antonio Amarillo Ramírez et al. „Book reviews - Crítica de libros - Crítica de livros (Historia Agraria, 75)“. Historia Agraria. Revista de agricultura e historia rural 75 (01.06.2018): 201–61. http://dx.doi.org/10.26882/histagrar.075r08a.
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Book reviews - Crítica de libros - Crítica de livros José Roberto Álvarez Múnera:Mercado, ganado y territorio: Haciendas y hacendados en el Oriente y el Magdalena Medio antioqueños (1920-1960) Shawn Van Ausdal Germán Carrillo García: Desarrollo rural y cooperativismo agrario en Ecuador: Trayectorias históricas de los pequeños productores en la economía global Jackeline Velazco Portocarrero John Broad & Anton Schuurman (Eds.):Wealth and Poverty in European Rural Societies from the Sixteenth to the Nineteenth Century Christine Fertig Eric L. Jones: Revealed Biodiversity: An Economic History of the Human Impact Ricard Soto Richard W. Hoyle (Ed.): Custom, Improvement and the Landscape in Early Modern Britain. The Farmer in England, 1650-1980 Gabriel Jover Teresa María Ortega (Ed.): Jornaleras, campesinas y agricultoras: La historia agraria desde una perspectiva de género Inmaculada Villa Salvador Calatayud, Jesús Millán & María Cruz Romeo (Eds.): El Estado desde la sociedad: Espacios de poder en la España del siglo XIX Antonio Amarillo Ramírez Manuel de Paz: Fruta del paraíso: La aventura atlántica del plátano Belinda Rodríguez Arrocha Rolf Kieβsling, Frank Konersmann, Werner Troβbach & Dorothee Rippmann: Grundzüge der Agrargeschichte. 1: Vom Spätmittelalter bis zum Dreiβigjährigen Krieg (1350-1650) Carolina Batet Reiner Prass, Stefan Brankensiek (Ed.) & Jürgen Schlumbohm: Grundzüge der Agrargeschichte. 2: Vom Dreiβigjährigen Krieg bis zum Beginn der Moderne (1650-1880) Jesús Millán Gunter Mahlerwein & Clemens Zimmermann (Ed.): Grundzüge der Agrargeschichte. 3: Die Moderne Gloria Sanz Lafuente Enric Vicedo: Pagesia, accés a la terra i desenvolupament històric: Els latifundis eclesiàstics a la Catalunya occidental plana (segles XVII-XX) Antònia Morey Tous Pere Bosch: La lluita per la terra: Solidaritats pageses i conflictivitat rural a la regió de Girona (1931-1936) Raimon Soler Pilar Díaz Sánchez: Vida de Antonio y Carmelita: La militancia jornalera en Andalucía (1950-2000) Carlos Gil Andrés Antonio Escobar, Romana Falcón & Martín Sánchez Rodríguez (Coords.): La desamortización civil desde perspectivas plurales Ángel Ramón del Valle
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Remuzgo Martinez, S., F. Genre, V. Pulito-Cueto, D. Prieto-Peña, B. Atienza-Mateo, B. Sevilla, J. Llorca et al. „AB0012 ROLE OF IRF5 GENE ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS“. Annals of the Rheumatic Diseases 79, Suppl 1 (Juni 2020): 1309.1–1310. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1023.
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Background:Interferon signaling pathway plays a relevant role in autoimmunity. Genetic variants in theinterferon regulatory factor (IRF) 5gene, that encodes the major regulator of the type I interferon induction [1], have been related to the development of several inflammatory diseases [2].Objectives:To determine the influence ofIRF5on Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular disease.Methods:ThreeIRF5polymorphisms (rs2004640, rs2070197 and rs10954213) representative of 3 different haplotype blocks were genotyped in 372 Caucasian patients with IgAV and 876 sex and ethnically matched healthy controls.Results:No statistically significant differences between patients with IgAV and controls were observed when eachIRF5polymorphism was analyzed independently. Similarly, no statistically significant differences between patients with IgAV and controls were found whenIRF5polymorphisms were evaluated combined conforming haplotypes. Additionally, there were no statistically significant differences in genotype, allele and haplotype frequencies ofIRF5when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations.Conclusion:Our results do not support an influence ofIRF5on the pathogenesis of IgAV.References:[1]Nat Immunol 2011; 12: 231-8;[2]Arthritis Res Ther 2014; 16: R146.Acknowledgments:This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) (grant CP16/00033). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, co-funded by the European Regional Development Fund (ERDF)). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). LL-G is supported by funds of PI18/00042 (ISCIII, co-funded by ERDF).Disclosure of Interests:Sara Remuzgo Martinez: None declared, Fernanda Genre: None declared, Verónica Pulito-Cueto: None declared, D. Prieto-Peña: None declared, Belén Atienza-Mateo: None declared, Belén Sevilla: None declared, Javier Llorca: None declared, Norberto Ortego: None declared, Leticia Lera-Gómez: None declared, Maite Leonardo: None declared, Ana Peñalba: None declared, María Jesús Cabero: None declared, Luis Martín-Penagos: None declared, Jose Alberto Miranda-Filloy: None declared, Antonio Navas Parejo: None declared, Javier Sanchez Perez: None declared, Maximiliano Aragües: None declared, Esteban Rubio: None declared, MANUEL LEON LUQUE: None declared, Juan María Blanco-Madrigal: None declared, E. Galindez: None declared, Javier Martin Ibanez: None declared, Santos Castañeda: None declared, Ricardo Blanco Grant/research support from: Abbvie, MSD and Roche, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen, Lilly and MSD, Miguel A González-Gay Grant/research support from: Pfizer, Abbvie, MSD, Speakers bureau: Pfizer, Abbvie, MSD, Raquel López-Mejías: None declared
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Garrido-Barros, Maria, Javier Oliver, Juan Luis Onieva, Beatriz Martinez-Galvez, Jaime Duddelman, Antonio Rueda, Elisabeth Perez et al. „Abstract 3746: Dynamic characterization of small RNAs in non small cell lung cancer exosomes under immune-checkpoint inhibitor treatments“. Cancer Research 83, Nr. 7_Supplement (04.04.2023): 3746. http://dx.doi.org/10.1158/1538-7445.am2023-3746.
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Abstract Immunotherapy based on Immune Checkpoint blockade (ICB) has become a significant therapeutic option for advanced Non Small Cell Lung Cancer (NSCLC) patients. However, there is an urgent need to find novel biomarkers that to reliably stratify good responders to immunotherapy. Currently, the available biomarkers are not specific enough. Exosomes are small membrane vesicles with sizes of 30-100 nm secreted by most cell types including cancer cells. Exosomes operate as an intercellular communication system by sending proteins, mRNA and miRNAs among other relevant RNA molecules. Exosomes enriched with miRNAS are involved in proliferation, differentiation, maduration and immune cell activation. Moreover, in cancer cells miRNA and other small RNA molecule expressions are dysregulated. Exosomes produced from cancer patient's plasma have been shown to be accurate diagnostic tools for the disease. In this study we profiled miRNAs and other small RNA cargo by exosome of plasma samples from 77 Non Small Cell Lung Cancer (NSCLC) metastatic patients before and after the first cycle of immunotherapy to evaluate the potentiality of predicting response to immunotherapy. We perform exosomes together with RNA isolation and small RNAseq sequencing from plasma samples before and after the first ICB cycle. Two independent softwares were used to identify small RNAs (RNAtoolbox and mirMaster). Prior ICB treatment we did not find differentially expressed miRNAs or other small RNA between good and bad responders. Interestingly we identified 12 exosomal miRNA differentially expressed between good and bad responders after the first cycle of ICB. Intriguingly, levels of miR-134-5p, miR-142-3p, miR-143-3p among others previously associated with NSCLC were found to be considerably higher in the good responder group than the bad responder group. Regarding other smallRNA molecules we observed a great variety and variability of piRNA, rRNA, scaRNA, lncRNA, snoRNA, snRNA, miscRNA and circRNA. To address the function of miRNA and other differentially expressed RNA molecules, we consulted KEGG, GO and Reactome for gene regulatory networks. Interestingly, KEGG results show pathways in cancer as top hit and Reactome highlight Immune System and cancer hits. In conclusion, we observed that patients that have favorable response to ICB have distinctive plasma exosomal miRNA patterns that could be used as possible biomarkers for predicting the effectiveness of immunotherapy in advanced NSCLC patients Citation Format: Maria Garrido-Barros, Javier Oliver, Juan Luis Onieva, Beatriz Martinez-Galvez, Jaime Duddelman, Antonio Rueda, Elisabeth Perez, Emilio Alba, Inmaculada Ramos, Juan Zafra, Manuel Cobo, Isabel Barragán. Dynamic characterization of small RNAs in non small cell lung cancer exosomes under immune-checkpoint inhibitor treatments. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3746.
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Martínez Peñín, Raquel. „Presentación. Evolución de los espacios urbanos y sus territorios en el noroeste de la Península Ibérica (II)“. Estudios Humanísticos. Historia, Nr. 17 (15.12.2020): 11. http://dx.doi.org/10.18002/ehh.i17.7650.
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El presente monográfico contiene una serie de investigaciones especializadas que, sin duda, contribuirán a ampliar sustancialmente el conocimiento científico que tenemos sobre determinadas realidades habitacionales y materiales del área septentrional de la Península Ibérica. Además, los sitios arqueológicos recogidos en este volumen responden a contextos tanto de carácter rural como urbano y con un amplio abanico cronológico que abarca realidades que van desde la Protohistoria hasta la Edad Media. Así pues, el primero de los trabajos de este número se inicia con el estudio realizado por Hugo Lozano Hermida, Eduardo Ramil Rego, José Manuel Caamaño Gesto y Sara Barbazán Domínguez titulado “Castreños y romanos en el occidente cantábrico: estado de la cuestión y algunas reflexiones”, centrado en el estudio de una serie de zonas arqueológicas emplazados en el área geográfica sita entre Punta de Estaca de Bares y la Ría de Ribadeo que datan de entre la Edad de Hierro y el periodo romano. Seguidamente, el equipo dirigido por Alfonso Fanjul Pereza nos ofrece un análisis sobre la realidad socio-económica del asentamiento asturianos de Las Vallinas, de fines de la Prehistoria e inicios de la dominación romana, comparándolo además con otros sitios conocidas en la costa del Golfo de Vizcaya. Por otro lado, Mario César Vila y Manuela Pérez Mato en su artículo “El yacimiento de San Esteban (Cacabelos, León) y su relación con Bergidum Flavium: síntesis y resultado de la intervención arqueológica realizada en 2014”, nos muestras el resultado de los trabajos de campo desarrollos con motivo de las obras de modernización de regadíos del Canal Alto del Bierzo. También se incluye en este número el análisis que Carlos Fernández Rodríguez, Eduardo González Gómez de Agüero, Natividad Fuertes Prieto y Víctor Bejega García han realizado sobre los productos del mar localizados en una serie de asentamiento del interior del noroeste de la Península Ibérica durante el periodo de dominación romana. En esta misma línea, el artículo que encabeza Esteban Álvarez Fernández está dedicado al análisis de los restos faunísticos exhumados en el poblado zamorano de El Castillón que data de entre los siglos V y VI.
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Kalinsky, Kevin M., William E. Barlow, Julie R. Gralow, Funda Meric-Bernstam, Kathy S. Albain, Daniel F. Hayes, Nancy U. Lin et al. „Abstract GS2-07: Updated results from a phase 3 randomized clinical trial in participants (pts) with 1-3 positive lymph nodes (LN), hormone receptor-positive (HR+) and HER2-negative (HER2-) breast cancer (BC) with recurrence score (RS) ≤ 25 randomized to endocrine therapy (ET) +/- chemotherapy (CT): SWOG S1007 (RxPONDER)“. Cancer Research 82, Nr. 4_Supplement (15.02.2022): GS2–07—GS2–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs2-07.
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Abstract Background: We previouslyreported that invasive disease-free survival (IDFS), the primary outcome, and distantdisease-free survival (DDFS), a secondary outcome, differed by menopausalstatus in a pre-specified analysis. Here,we report updates on IDFS and DDFS with additional follow-up, as well as distantrecurrence-free interval (DRFI) and post hoc analyses in premenopausal women.Methods: Eligibilitycriteria included women > 18 years of age with HR+, HER2-BC and 1-3 +LN and no contraindications to taxane and/or anthracycline basedCT. DRFI was defined as time to distant recurrence or death from breast cancer.Analyses were intent-to-treat among eligible pts. We performed a post hocanalysis evaluating IDFS between treatment arms in premenopausal pts with pN1mi.In addition, we conducted a two-year landmarked IDFS analysis by ovarianfunction suppression (OFS) or not in the ET arm, as well as by regularmenstrual periods or not in both treatment arms.Results: Among the 4,984eligible pts, there were 553 IDFS events and median follow-up of 6.1 years.Postmenopausal women do not have any IDFS or DDFS benefit with CT; however, 5-yearabsolute benefits for IDFS and DDFS with CT for premenopausal pts were 5.9% and3.3%, respectively. In pre-menopausal pts, CT was associated with improved DRFIfor all RS values < 25, with an absolute improvement of 2.3% for RS0-13 and of 2.8% for RS 14-25. Among premenopausal pts, 12.4% (n=206) had pNmi)disease. In a post hoc analysis, there was a trend for CT benefit for thosewith pNmi [hazard ratio (HR)=0.44, confidence interval (CI)=0.18-1.08]. Therewere only 22 IDFS events. Only 17.2% of premenopausal pts assigned to ETunderwent OFS in the first 24 months and in two-year landmarked analysis, therewas no IDFS difference in those who underwent OFS or not (HR=0.88,CI=0.47-1.63). In premenopausal women assigned to ET, 58.9% stopped havingperiods within the first 24 months, and have anumerically improved IDFS compared to those who continued regular periods (HR=1.48,CI: 0.92-2.40). Among premenopausal assigned to CT followed by ET, 80.8%stopped having periods within the first 24 months and have a numericallyimproved IDFS compared to those who continue to have regular periods (HR=1.56, CI:0.85-2.86).Discussion: In accordancewith the differential IDFS and DDFS benefit based upon menopausal status inS1007, premenopausal pts with 1-3+LN and RS < 25 had a statisticallysignificant improvement in DRFI with the addition of CT. A small proportion of S1007premenopausal participants underwent OFS. The role of OFS as it relates to CTbenefit cannot be determined from this study. A future randomized trial should address the clinical question if OFScan replace CT in premenopausal pts with HR+/HER2-, node-positive breast cancer.Funding: Supported by National Cancer Institute grants U10CA180888, U10CA180819,U10CA180820, U10CA180821, U10CA180868, U10CA180863, and in part by Susan G.Komen for the Cure® Research Program, The Hope Foundation for Cancer Research,Breast Cancer Research Foundation, and Genomic Health, Inc. Citation Format: Kevin M Kalinsky, William E Barlow, Julie R Gralow, Funda Meric-Bernstam, Kathy S Albain, Daniel F Hayes, Nancy U Lin, Edith A Perez, Lori A Goldstein, Stephen KL Chia, Sukhbinder Dhesy-Thind, Priya Rastogi, Emilio Alba, Suzette Delaloge, Miguel Martin, Catherine M Kelly, Manuel Ruiz-Borrego, Miguel Gil-Gil, Claudia H Arce-Salinas, Etienne GC Brain, Eun Sook Lee, Jean-Yves Pierga, Begoña Bermejo, Manuel Ramos-Vasquez, Kyung Hae Jung, Jean-Marc Ferrero, Anne Schott, Steven Shak, Priyanka Sharma, Danika Lew, Jieling Miao, Debasish Tripathy, Lajos Pusztai, Gabriel Hortobagyi. Updated results from a phase 3 randomized clinical trial in participants (pts) with 1-3 positive lymph nodes (LN), hormone receptor-positive (HR+) and HER2-negative (HER2-) breast cancer (BC) with recurrence score (RS) ≤ 25 randomized to endocrine therapy (ET) +/- chemotherapy (CT): SWOG S1007 (RxPONDER) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr GS2-07.
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Bello-Gualtero, J. M., E. Peña, P. I. Santos Moreno, J. Vesga Gualdrón, G. Saavedra und C. Perez. „POS0501 SUSTAINED 2-YEAR REMISSION OF THE DISEASE IN A CLINIC OF EXCELLENCE IN RHEUMATOID ARTHRITIS. EXPERIENCE OF THE CLINICAL REGISTRY IN COLOMBIA“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 483.1–483. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3886.
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Background:Rheumatoid arthritis (RA) is a chronic autoimmune disease with no cure, characterized by episodes of exacerbation and remission, which requires permanent use of medications. Clinics of excellence are multidisciplinary and centralized programs that improve adherence to treatments. Information on the benefits of these models of care has been published but is not definitive. In Colombia, the clinical registry of patients with RA is kept in the Cuenta de Alto Costo (CAC).Objectives:To demonstrate the difference in the percentages of sustained remission at 2 years, between an institution with non-centralized management or standard of care (Hospital Militar Central-HMC) compared to another institution with centralized management or clinic of excellence (BIOMAB-IPS) and determine if the results are determined by any of the intervention variables or by the program.Methods:The 2-year clinical records for the CAC were compared between an institution with non-centralized management (HMC) in comparison with another institution with centralized management (BIOMAB-IPS), performing a sociodemographic description, measuring control of the disease DAS28 clinimetry, Fisher’s test non-parametric bivariate analysis, multiple regression model, and population matching with Propensity score Matching (PSM).Results:Complete information was obtained from 2 years of follow-up, in centralized management 3457 patients and for the non-centralized unit 114 patients. Most of them corresponded to 2962 women (82%), with time of illness of 9.5 years and 10.2 years, respectively, without statistically significant differences. A difference was observed in the 2 programs to maintain remission at 2 years, in favor of the centralized program 54.7% vs 28.6.2% (p <0.00). With the binomial generalized linear regression model, it was confirmed that this difference was not explained by variables such as the use of biological therapy (RR = 0.77; 95% CI 0.69-0.86), use of DMARDs (RR = 0.71; 95% CI 0.62-0.82) and number of rheumatology consultations (RR = 0.97; 95% CI 0.92-1.02) in comparison with the centralized care model (RR = 2.32; 95% CI 1.58-3.35). Due to the biases between the groups due to the non-probability sampling, a PSM was performed, with a 1: 1 match, caliper of 0.065, obtaining a pseudo population with well-balanced covariates (see table 1). In the common support area, statistically significant differences were documented in sustained remission over 2 years, in favor of the centralized care group 45 vs 17.9% (p = 0.001).Conclusion:With the information from the clinical records, statistical strategies can be used to evaluate important differences in centralized care programs, observing favorable results of these types of care that are not related to isolated elements of the program, but to the overall effect of the program.References:[1]Austin PC. Double propensity-score adjustment: A solution to design bias or bias due to incomplete matching. Stat Methods Med Res. 2017;26(1):201–22.33333Disclosure of Interests:Juan Manuel Bello-Gualtero: None declared, Esperanza Peña: None declared, Pedro Iván Santos Moreno: None declared, Jasmin Vesga Gualdrón Employee of: Baxter, Ginna Saavedra: None declared, Clara Perez: None declared
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Almodovar, R., P. Zarco-Montejo, A. Bueno und L. M. Molinero. „AB1077 VALIDATION OF A SIMPLIFIED SPANISH TOOL FOR SEMI-AUTOMATIC QUANTIFICATION OF SACROILIAC INFLAMMATION BY MAGNETIC RESONANCE IN SPONDYLOARTHRITIS (S- SCAISS).“ Annals of the Rheumatic Diseases 79, Suppl 1 (Juni 2020): 1827.1–1827. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2134.
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Background:With the objective to improve quantification of sacroiliitis maintaining a practical perspective, our group developed SCAISS, a semi-automated method to measure bone marrow edema (BME) in MR images from sacroiliac (SI) joints, combining semi-axial and semi-coronal slices [1]. The 2009 ASAS definition of active sacroiliitis was based on standard semi-coronal slices only, perpendicular semi-axial slices being considered but optional [2]. We hypothesized a simplified SCAISS (s- SCAISS) method using only semi-coronal slices.Objectives:To analyze the validity and reliability and feasibility of a simplified Spanish tool for semi-automatic quantification of sacroiliac inflammation by magnetic resonance in spondyloarthritis (s- SCAISS) using a semi-coronal scan instead of combining semi-axial and semi-coronal slices.Methods:The s- SCAISS was designed as an image-processing software. We performed the following analysis: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with the s-SCAISS and SCAISS, and two non-automated methods, SPARCC and Berlin; (2) 20 readers evaluated 12 patients images, also with the three methods. Convergent validity, reliability and feasibility were estimated.Results:Theinterobserver reliability(ICC and 95% CI) in the three observers’ study was: s-SCAISS = 0.69 (0.490–0.845); SCAISS= 0.770 (0.580–0.889); Berlin = 0.725 (0.537–0.860); and SPARCC = 0.824 (0.671–0.916). In the 20 observers’ study, ICC was: s- SCAISS = 0.66 (0.478–0.863); SCAISS = 0.801 (0.653–0.927); Berlin = 0.702 (0.518–0.882); and SPARCC = 0.790 (0.623–0.923).Spearman correlation coefficientbetween s- SCAISS _BERLIN was r= 0.712 and s- SCAISS_ SPARCC was r= 0.779 and s- SCAISS _SCAISS was r= 0.90. Similar results showed SCAISS BERLIN and SCAISS_ SPARCC (r= 0.729 and 0.840), respectively.Conclusion:The simplified SCAISS (s-SCAISS) using only semi-coronal slice permits a valid, reliable, and fast calculation of overall BME lesion at the SI joint.References:[1]Zarco P, Almodóvar R, Bueno Á, Molinero LM; SCAISS Study Group.Development and validation of SCAISS, a tool for semi-automated quantification of sacroilitis by magnetic resonance in spondyloarthritis. Rheumatol Int. 2018 Oct;38(10):1919-1926.[2]Rudwaleit M, Jurik AG, Hermann KGA et al. Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approachby the ASAS/OMERACT MRI group. Ann Rheum Dis 2009; 68:1520-7.Acknowledgments:Mireia Moreno (Rheumatology, H. Parc Taulí), Xavier Juanola (Rheumatology, H. Bellvitge), Maite Ventemillas (Radiology, H. Parc Taulí), Victoria Navarro (Rheumatology, H. La Paz), Daniel Bernabeu (Radiology, H. La Paz), Rafael Montero Perez-Barquero (Radiology, H. Reina Sofía de Córdoba), Concha Crespo (Radiology, H. de San Juan de Alicante), Enrique Batlle (Rheumatology, H. de San Juan de Alicante), Carmen Castro Copete (Radiology, H. H. de San Juan de Alicante), Carlos Quiles (Radiology, H. General Universitario de Valencia), Emma Beltrán (Rheumatology, H. del Mar), Fran García Lorente (Rheumatology, H. Universitario de Basurto), Fernando Díez (Radiology, H. Universitario de Basurto), Luis Linares (Rheumatology, H. Virgen de la Arrixaca), Manuel José Moreno Ramos (Rheumatology, H. Virgen de la Arrixaca), Angela Cepero (Radiology, H. H. Virgen de la Arrixaca), Cristina Fernández Carballido (Rheumatology, H. de Elda), Christopher Pack (Radiology, H. de Elda).Disclosure of Interests:RAQUEL ALMODOVAR Speakers bureau: Abbvie, Celgene, Janssen, Lilly, Novartis, Pfizer., Pedro Zarco-Montejo Speakers bureau: Abbvie, MSD, Novartis, Pfizer., Angel Bueno: None declared, Luis Miguel Molinero: None declared
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Barragan, Isabel, Elisabeth Perez-Ruiz, Juan Luis Onieva, Maria Garrido-Ramos, Beatriz Martinez-Galvez, Jaime Dubbelman, Emilio Alba et al. „Abstract 1044: Cell-free DNA concentration as a prognostic biomarker in patients with non-small cell lung cancer under immunotherapy treatment“. Cancer Research 83, Nr. 7_Supplement (04.04.2023): 1044. http://dx.doi.org/10.1158/1538-7445.am2023-1044.
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Abstract The irruption of the immunotherapy for the treatment of non-small cell lung cancer (NSCLC) based on Immune Checkpoint Inhibitors (ICI) PD-1 and PD-L1 inhibitors is considered a treatment revolution. However, only a small percentage of patients benefit with ICI treatment over the long term, and precise biomarkers that can recognize these individuals before or early during treatment have so far eluded. PD-L1 expression and tumor mutational burden (TMB) are the most well studied biomarkers for predicting response to PD- (L)1 blockade-based ICI prior to treatment. TMB is still being clinically assessed whereas PD-L1 has several drawbacks for prediction of persistent benefit. Our aim is to evaluate the basal state and dynamic changes of cell-free DNA (cfDNA) concentration to predict and monitor response in NSCLC patients starting ICI. A total of 248 cfDNA concentration measurements were performed from 87 NSCLC patients. The quantification was done before the start of the treatment, at the second ICI cycle, after 6 and 12 months in treatment, and at progression if it was within the first 12 months. Quality and quantity of the cfDNA was assessed using Qubit High Sensitivity and Bioanalyzer 2100. We first explored the association with response of the basal cell-free DNA concentration using Mann-Whitney-Wilcoxon test. The longitudinal analysis between different time points was tested with Wilcoxon signed-rank tests. Response was ascertained using RECIST parameters at 3, 6, and 12 months. We evaluated the utility of the cfDNA concentration as a prognostic factor using Mantel-Cox test. The response association results indicate that early and long-term response is associated with lower levels of basal cfDNA (p<0.002, 3 months; p<0.001, 6 months; p<0.05, 12 months). The longitudinal analysis could also detect a decrease in cfDNA from the second cycle to the month 6 of treatment in responders (p<0.05), and an increase in non-responders (p<0.05). To identify a prognostic concentration threshold, statistical stratification of cfDNA levels based on the selected maximum rank method of cfDNA levels was used to group them into low and high concentration. Patients with high basal cfDNA concentrations showed both worse FPS (log-rank 3.4x10-03, Medians: Low 12.57 [8.36 - 18.46] High 5.50 [3.03 - 10.06]) and OS (log-rank 3.2x10-05, Medians: Low 21.26 [15.33 - 33.96] High 5.45 [3.10 - 15.66]). With these results, we provide proof-of-principle that specifically detecting tumor cfDNA by PCR or NGS methods would not be necessary to predict the long-term clinical benefit to ICI in NSCLC patients. Moreover, concentration cut-offs can be defined to categorize the patients in potential responders and non-responders before the start of the treatment. This would constitute a cost-effective and easily implementable prognostic tool that could be particularly useful for avoiding loss of treatment windows of opportunities. Citation Format: Isabel Barragan, Elisabeth Perez-Ruiz, Juan Luis Onieva, Maria Garrido-Ramos, Beatriz Martinez-Galvez, Jaime Dubbelman, Emilio Alba, Juan Zafra, Manuel Cobo, Javier Oliver, Antonio Rueda-Dominguez. Cell-free DNA concentration as a prognostic biomarker in patients with non-small cell lung cancer under immunotherapy treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1044.
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Pérez-García, José Manuel, Fara Brasó-Maristany, Elena Martínez-García, Carmen Mora Gallardo, Eileen Shimizu, Olga Boix Sánchez, Jose Rodríguez-Morató et al. „Abstract 5213: Evaluation of HER2DX risk-score in residual disease (RD) from HER2-positive (HER2+) early breast cancer (EBC) patients (pts) following neoadjuvant trastuzumab and pertuzumab (HP)-based therapy: An exploratory analysis from the PHERGain trial“. Cancer Research 84, Nr. 6_Supplement (22.03.2024): 5213. http://dx.doi.org/10.1158/1538-7445.am2024-5213.
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Abstract Introduction: HER2DX is a prognostic (risk-score) and predictive (pathological complete response-score) genomic assay validated in baseline (BL) tumor samples from HER2+ EBC pts. RD after neoadjuvant anti-HER2-based therapy is associated with worse outcomes. Whether HER2DX risk-score analyzed in RD provides additional prognostic information is unknown. Methods: This retrospective analysis included 14 pts from group B of the PHERGain trial (NCT03161353): 6 who developed distant recurrences and 8 matched controls with HER2DX high-risk score at BL who did not. Group B pts had centrally confirmed, stage I-IIIA, HER2+ EBC and were treated with HP (± endocrine therapy), with chemotherapy added for pts without PET response after 2 treatment cycles or pathological complete response (Perez-Garcia et al, Lancet Oncol 2021).HER2DX was evaluated on tumor samples collected at BL and surgery. The primary objective was to determine the association of HER2DX risk-score in RD with the development of distant recurrences. Secondary objectives were to assess gene expression and the HER2DX signatures in BL vs RD and their association with distant recurrences. Cox regression models evaluated the association of variables with distant recurrence. Paired SAM with a false discovery rate <5% identified differences in gene expression between BL and RD samples. Results: Median follow-up was 4.04 years. Five (83.3%) of 6 pts with distant recurrences had HER2DX high-risk scores at BL. The 8 control pts had HER2DX high-risk scores at BL but no relapse. In RD, all 6 pts (100%) who relapsed had a HER2DX high-risk score, while 4 (50%) of 8 pts without distant recurrence presented a HER2DX downstaging. Pts with HER2DX low-risk in RD had better 3-year distant disease-free survival than high-risk pts (100% vs 50%; hazard ratio = 4.34 [1.03-18.23], p=0.045). In RD, high expression of the proliferation signature and 15 genes, including proliferation genes, and low expression of 38 genes, including immune and luminal-related genes, were associated with poor prognosis. In paired analyses of BL and RD samples, 118 genes (63.8%) were differentially expressed in pts that did not relapse, while only 3 genes (1.6%) were differentially expressed in pts that relapsed. Conclusions: These data suggest that HER2DX risk-score in RD provides additional information on the likelihood of developing distant recurrences. In RD, high expression of immune and luminal genes was associated with a reduced risk, while high expression of proliferation genes was associated with a higher risk. Molecular changes after anti-HER2 therapy were mainly observed in RD of pts that did not relapse. Prognostic impact of HER2DX downstaging merits further evaluation. Citation Format: José Manuel Pérez-García, Fara Brasó-Maristany, Elena Martínez-García, Carmen Mora Gallardo, Eileen Shimizu, Olga Boix Sánchez, Jose Rodríguez-Morató, Mario Mancino, Laia Paré, Guillermo Villacampa, Mercedes Marín-Aguilera, Patricia Galván, Ana Vivancos, Patricia Villagrasa, Joel Parker, Charles M. Perou, Antonio Llombart-Cussac, Javier Cortés, Aleix Prat. Evaluation of HER2DX risk-score in residual disease (RD) from HER2-positive (HER2+) early breast cancer (EBC) patients (pts) following neoadjuvant trastuzumab and pertuzumab (HP)-based therapy: An exploratory analysis from the PHERGain trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5213.
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Bisson, Thomas N. „Catalunya Carolíngia, 5: Els comtats de Girona, Besalú, Empúries i Peralada. Ramon Ordeig i Mata , Santiago Sobrequés i Vidal , Sebastià Riera i Viader , Manuel Rovira i Solà Catalunya Carolíngia, 6: Els comtats de Rosselló, Conflent, Vallespir e Fenollet. Ramon Ordeig i Mata , Pere Ponsich“. Speculum 83, Nr. 1 (Januar 2008): 230–31. http://dx.doi.org/10.1017/s0038713400012860.
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Silveira, Lucas, Maura Seiko Tsutsui Esperancini, Franklin De Souza Barbosa und Rogério Peres Soratto. „COLHEITA DO CAFÉ DE QUALIDADE: CUSTO E RETORNO PARA OS PRODUTORES DA REGIÃO DE MANTIQUEIRA DE MINAS - MG“. ENERGIA NA AGRICULTURA 35, Nr. 3 (29.09.2020): 437–46. http://dx.doi.org/10.17224/energagric.2020v35n3p437-446.
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COLHEITA DO CAFÉ DE QUALIDADE: CUSTO E RETORNO PARA OS PRODUTORES DA REGIÃO DE MANTIQUEIRA DE MINAS - MG
LUCAS SILVEIRA1, MAURA SEIKO TSUTSUI ESPERANCINI2, FRANKLIN DE SOUZA BARBOSA3, ROGÉRIO PERES SORATTO4
1 Departamento de Engenharia Rural e Socioeconomia, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. silveiralucas@live.com
2 Departamento de Engenharia Rural e Socioeconomia, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. maura.seiko@unesp.br
3 Departamento de Engenharia Rural e Socioeconomia, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. franklin.barbosa@unesp.br
4 Departamento de Produção Vegetal, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. rogerio.soratto@unesp.br
RESUMO: O segmento de cafés tornou-se um mercado bastante complexo no que tange gerenciamento das lavouras, gestão de custos de produção e comercialização das sacas de café produzidas. O objetivo deste estudo é verificar o impacto dos custos de diferentes métodos de colheita no preço final de venda, bem como verificar os ganhos monetários obtidos na produção de cafés especiais no município de Carmo de Minas (MG). Os dados deste estudo buscam subsidiar a tomada de decisão quanto ao tipo de colheita e aos retornos esperados em termos de preços de venda do produto. A metodologia adotada foi a de conversão das unidades de campo (balaios) para a unidade de comercialização do café (sacas de 60 kg). Os dados levantados permitem ao produtor desenvolver estratégias de manejo da lavoura de café para que atendam aos padrões do mercado, maximizando o retorno sobre os custos de colheita adotada. Dentre os métodos de colheita avaliados, a colheita manual selecionada tem maior potencial de retornos vantajosos para um sistema de produção de cafés especiais em Carmo de Minas (MG).
Palavras-chaves: custo de colheita, cafés especiais, métodos de colheita.
SPECIALTY COFFEE HARVEST: COST AND BENEFIT TO FARMERS IN THE MANTIQUEIRA DE MINAS AREA – MG
ABSTRACT: Coffee market has become an overly complex market in terms of crop, cost, and sales management. The aim of this study was to verify the impact of different harvesting methods costs on sales price as well as to verify economic profits obtained by specialty coffees in Carmo de Minas (MG). The data addresses the decision-making regarding the picking system and the expected returns in terms of sales prices. The methodology foresees the conversion of field units (balaio) to coffee sales units (bags of 60 kg). The data collected allows the producer to develop coffee crop management strategies to come into the market standards, maximizing returns among the harvest costs. Amid the picking methods evaluated, the hand-picked coffee has the greatest potential for beneficial returns for a special coffee production system in Carmo de Minas (MG).
Keywords: harvesting cost, specialty coffee, harvesting systems.
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Priego, Neibla, Pedro García-Gómez, Ana de Pablos-Aragoneses, María Perea-García, Laura Álvaro-Espinosa, Carolina Hernández-Oliver, Elena Martínez-Saez et al. „Abstract 5105: TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis“. Cancer Research 83, Nr. 7_Supplement (04.04.2023): 5105. http://dx.doi.org/10.1158/1538-7445.am2023-5105.
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Abstract Brain metastasis is an unmet clinical need, affecting between 10-30% of cancer patients with 200000 to 400000 newly diagnosis per annum in the US. Recently, several clinical trials have reported benefits using immunotherapy to treat brain metastasis. However, variability of the responses is broad and high benefit is found mainly in asymptomatic brain metastasis, while the benefit is dramatically reduced in the clinically relevant stage. Thus, it is currently unknown how to effectively target symptomatic brain metastases with immunotherapy. We previously reported a clinically relevant protumoral program driven by STAT3 activation in a subpopulation of reactive astrocytes in these advanced stages of the disease. Our current study further exploited the heterogeneity within the metastasis-associated microenvironment as a resource to identify novel therapeutic vulnerabilities to improve the benefits of immunotherapies based on immune checkpoint blocking antibodies (ICB) in symptomatic brain metastasis. Our results demonstrate that reactive astrocytes are strong immunomodulatory cells in brain tumors. We have identified the molecular profile of disease-associated glial cells and defined its connection to modulatory activities on specific lymphocyte populations in experimental brain metastasis as well as human-derived samples. scRNASeq and high content multiplex immunofluorescence allowed us to report a novel local immunomodulatory axis dependent on TIMP1 (astrocytes)/CD63 (CD8 T cells), which is present in brain metastasis patients with high immunoscore and would imply an additional immunosuppressive signal for potential ICB responders in brain metastasis. Genetic and pharmacologic approaches targeting this STAT3-dependent local immunomodulatory axis have allowed us to define the rationale to combine immune checkpoint blockade with a STAT3 inhibitor, which we previously used in patients. We proved that such combined immunotherapy boost the systemic activation of T cells while also preventing the local blockade. Additionally, our comprehensive strategy includes the possibility to stratify patients that are best qualified to benefit from this therapy by measuring TIMP1 in liquid biopsies from CSF. Even more, our data using Patient Derived Organotypic Cultures (PDOC) from fresh brain metastasis neurosurgeries confirms that our therapeutic strategy might benefit brain metastases generated from any primary source. In conclusion, we describe an immunosuppressive mechanism in the brain microenvironment that could explain the lack of response to ICB in patients with advanced brain metastasis. Our finding provides the rationale to implement complementary approaches targeting local immunosuppression to increase the benefit of immunotherapy in symptomatic brain metastasis. Citation Format: Neibla Priego, Pedro García-Gómez, Ana de Pablos-Aragoneses, María Perea-García, Laura Álvaro-Espinosa, Carolina Hernández-Oliver, Elena Martínez-Saez, Ángel Pérez-Núñez, Aurelio Hernández-Laín, Rebeca Sanz-Pamplona, Marc Schmitz, Stephen J. Crocker, Diego Serrano, Asís Palazón, RENACER Red Nacional de Metástasis Cerebral, Manuel Valiente. TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5105.
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Peres, Ana Flavia Souza, Ingridy Izabella Vieira Cardoso, Janaina Mello Soares Galvao, Ana Glenda Santarosa Vieira, Marcela Nunes Rosa, Isabela Cristiane Tosi, Daniel Antunes Moreno et al. „Abstract 2856: Multi-omics approaches for biomarker discovery and target therapy in pediatric germ cell tumors“. Cancer Research 84, Nr. 6_Supplement (22.03.2024): 2856. http://dx.doi.org/10.1158/1538-7445.am2024-2856.
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Abstract Pediatric germ cell tumors (GCT) are rare and heterogeneous, presenting various histologies. There are no specific markers for diagnosing GCT, and 30% of patients are resistant to standard cisplatin-based chemotherapy, which can be related to epithelial-mesenchymal transition (EMT). Therefore, this study aims to elucidate markers for classifying GCTs, evaluate the molecular mechanisms related to drug resistance, and search for new therapeutic approaches. The expression of miRNAs was assessed for 42 GCT-pediatric patients through miRNA Panel - Nanostring technology. Whole Exome Sequencing (WES) was performed for 16 GCT-pediatric patients to assess somatic mutations. In silico analysis of epithelial-mesenchymal transition (EMT) markers was performed using the cBioPortal database. The expression of EMT markers was evaluated in vitro in parental and cisplatin-resistant models (NTERA-2R). Xenograft model-derived NTERA-2R was established and EMT markers were also assessed. We identified specific miRNA expression signatures for each histology, including 34 miRNAs for dysgerminomas, 13 for embryonal carcinomas, 25 for yolk sac tumors, and one for immature teratoma. We identified 26 miRNAs that were commonly expressed in malignant tumors, with six miRNAs (miR-302a-3p, miR-302b-3p, miR-371a-5p, miR-372-3p, miR-373-3p, miR-367-3p) showing significant overexpression. MiR-302b-3p had a significant association with all the evaluated clinical features. WES analysis showed that Single Base Substitution signature 39 was observed in 68.75% of samples and SBS22 in 12.5%. Copy number alterations were identified in 4, 7, 8, 10, 12, 21, and 22 chromosomes, with amplification of CDKN1B, KRAS, CCND2, ETV6, and KDM5A genes and deletions of KIT and PTEN genes. Somatic mutations in NYAP2, RHBDF2, MTOR, KIT, ATM, KRAS, and PIK3CA were frequent among the samples. KIT (Asp816Val, Ala829Pro) and KRAS (Gln61Leu) mutations were classified with potential clinical significance and were validated. In silico analysis showed that different histologies had distinct expression profiles for EMT markers. Patients with SNAILlowSLUGlow expression had higher PFS than those with SNAILhighSLUGhigh (p=0.006). The median PFS of patients with SLUGlow was 46.4 months, while SLUGhigh was 28.0 months (p=0.022). In vitro analysis using NTERA-2R showed overexpression of EMT markers. The same result was obtained in the xenograft model derived from NTERA-2R. Our study offers vital insights into pediatric GCTs' molecular landscape, using in silico, in vitro, in vivo analyses, and genetic assessments, highlighting three points: 1) The miRNA signatures for each histology may have robust diagnostic and prognostic potential, besides clinical implications as biomarkers. 2) KIT and KRAS genes are possible therapeutic targets of pediatric GCTs. 3) EMT is related to cisplatin resistance and SLUG is a potential molecular target. Citation Format: Ana Flavia Souza Peres, Ingridy Izabella Vieira Cardoso, Janaina Mello Soares Galvao, Ana Glenda Santarosa Vieira, Marcela Nunes Rosa, Isabela Cristiane Tosi, Daniel Antunes Moreno, Ana Carolina Laus, Andre van Helvoort Lengert, Silvia Aparecida Teixeira, Adriane Feijo Evangelista, Rui Manuel Reis, Luiz Fernando Lopes, Mariana Tomazini Pinto. Multi-omics approaches for biomarker discovery and target therapy in pediatric germ cell tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2856.