Dissertationen zum Thema „PDE2A“
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Lobo, Miguel Gonçalo de Oliveira Jones Ferrão. „Role of PDE2A in cAMP/PKA signaling compartmentalization“. Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:e647c600-48e4-4222-85e7-019f91745608.
Der volle Inhalt der QuelleDelhaye, Sébastien. „Rôle de la phosphodiestérase 2A dans la physiopathologie du syndrome de l’X fragile“. Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6014.
Der volle Inhalt der QuelleFragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID). In addition to ID, patients might exhibit autistic features, hyperactivity and attention-deficit disorder, language dysfunction and seizures. Approved and effective therapies are not yet available for FXS. The main hallmark of FXS in the brain is the presence of immature and denser dendritic spines. This abnormality is associated with altered synaptic plasticity in our animal model of FXS, the Fmr1-KO mice. FXS is caused by a CGG repeat expansion with a number of repeats higher than 200 in the 5’UTR of the Fragile X Mental Retardation 1 (FMR1) gene. Methylation of this region and of its surrounding sequences, including the promoter of FMR1, results into the silencing of the gene and the loss of its encoded protein, FMRP. An expansion with a number of repeats variable between 50 and 200 is considered as a premutation and is associated with two pathological conditions other than FXS: the Fragile X-associated Tremor Ataxia Syndrome (FXTAS), and the Fragile Xassociated Primary Ovarian Insufficiency (FXPOI). FMRP is an RNA-binding protein implicated in various steps of RNA metabolism. In particular, it plays a role in the translational regulation of a subset of synaptic proteins. We showed that FMRP modulates the synaptic expression of Phosphodiesterase 2A (PDE2A), an enzyme implicated in the degradation of cAMP and cGMP. In. the absence of FMRP, the levels and the activity of PDE2A are increased, and, consequently, cAMP/cGMP levels are reduced in the cortex and hippocampus of Fmr1-KO mice. The blockade of PDE2A with a specific and powerful inhibitor of PDE2A, Bay 607550, rescues various in vitro, ex vivo and in vivo FXS phenotypes. In particular, I contributed to this study by showing that the treatment with Bay 60-7550 rescues social deficits in young and adolescent Fmr1-KO mice and abnormal dendritic spine morphology in hippocampus. In order to validate this new therapeutic target for FXS, I crossed Pde2a+/- mice with Fmr1-KO mice and analyzed their behavior, neuronal morphology and signaling pathways linked to cAMP/cGMP levels in the hippocampus and cortex. I found that double mutant animals (Fmr1-KO x Pde2a+/-) have a normal social and cognitive behavior compared to both Fmr1-KO and Pde2a+/- mice. Indeed, Pde2a+/- mice display behavioral deficits similar to those characterizing the Fmr1-KO mouse, even if the molecular alterations seem to be opposite. In conclusion, my results highlight the key role of PDE2A-dependent cAMP and cGMP levels and their correlated pathways in neurodevelopment. Furthermore, in addition to my main project, in the first part of my doctoral stage, I participated to the characterization of neuronal morphology in the mice model of FXTAS showing that this neurodevelopmental marker is dependent on the level of the Fmr1 mRNA, which displays elevated levels in these mice in the presence of the Fmr1 premutation
Law, Robert. „PDE3A signalling in blood platelets“. Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13761.
Der volle Inhalt der QuelleWilson, Moira Ann. „Characterisation and analysis of PDE4A phosphodiesterase isoforms“. Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307182.
Der volle Inhalt der QuelleJohnston, Lee Ann. „The investigation of two novel PDE4A enzymes“. Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400759.
Der volle Inhalt der QuelleLivie, Craig. „Determining the role of PDE2 within the mitochondria“. Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6683/.
Der volle Inhalt der QuelleBegg, Fiona A. „Cloning and biochemical characterisation of two novel PDE4A cAMP phosphodiesterases“. Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394925.
Der volle Inhalt der QuelleSekharan, Monica R. „Structural studies of the cGMP-binding GAF domain of PDE5A /“. Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.
Der volle Inhalt der QuelleErcu, Maria [Verfasser]. „Molecular mechanisms underlying PDE3A-caused hypertension with brachydactyly (HTNB) / Maria Ercu“. Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1222513862/34.
Der volle Inhalt der QuelleLounas, Amel. „Fonction et localisation de la PDE8A dans les cellules ovariennes porcines et son implication dans la stéroïdogenèse“. Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27731.
Der volle Inhalt der QuelleJiao, Kangwei [Verfasser], und Marius [Akademischer Betreuer] Ueffing. „Evaluation of Neuroprotective Interventions in Different Pde6a Mutant Animal Models for Retinitis Pigmentosa / Kangwei Jiao ; Betreuer: Marius Ueffing“. Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1197134891/34.
Der volle Inhalt der QuelleDas, Soumyaparna [Verfasser]. „Towards new treatments for hereditary photoreceptor degeneration : Pharmacological and genetic approaches to restore Ca2+ homeostasis and Pde6a function / Soumyaparna Das“. Tübingen : Universitätsbibliothek Tübingen, 2022. http://d-nb.info/1234450895/34.
Der volle Inhalt der QuelleRuivo, António Filipe de Matos. „Aplicabilidade do modelo de regulação económica vigente na Colômbia para o setor dos serviços de águas ao contexto português“. Master's thesis, Instituto Superior de Economia e Gestão, 2014. http://hdl.handle.net/10400.5/7445.
Der volle Inhalt der QuelleOs serviços públicos de abastecimento de água para consumo humano e saneamento de águas residuais, designados de serviços de águas, sendo prestados por entidades que operam em regime de monopólio natural, e nesta medida, regulados na maioria dos países, são o objeto de estudo neste trabalho. Coloca-se a questão de como podem estes serviços, de interesse económico geral, e recentemente reconhecidos pela ONU como direitos humanos, ser universalmente prestados com qualidade, continuidade e a preços acessíveis, sem que as eventuais ineficiências das entidades que os prestam penalizem significativamente o preço cobrado aos consumidores. Tendo presente o modelo de regulação económica vigente na Colômbia para os serviços de ?acueducto y alcantarillado?, internacionalmente reconhecido como uma boa prática, pretende-se com este trabalho de investigação compreender este modelo nos seus aspetos fundamentais, para posteriormente se conseguir avaliar a possibilidade de implementação no contexto português. Para além de uma análise teórica aos fatores de contexto, foi possível testar a aplicação do modelo colombiano a um conjunto de entidades gestoras que operam em Portugal e retirar algumas conclusões. Deu-se especial relevância à componente eficiência incluída nas fórmulas tarifárias uma vez que os incentivos à melhoria contínua são um dos principais aspetos a melhorar no modelo regulatório português.
Public services of water supply for human consumption and wastewater disposal, also known as water services, are provided by operators that operate on natural monopolies and are, therefore, object of regulation in most countries. This reality brings the question of how can these services of general economic interest, recently recognized by the UN as human rights, be universally provided with quality, continuity and affordable, without increasing significantly the price charged to consumers due to the operators? inefficiencies. This research intends to understand the current model of economic regulation of these services in Colombia (services of ?acueducto y alcantarillado?), internationally recognized as good practice, and to assess the possibility of its implementation in the Portuguese context. Besides the theoretical analysis of context factors, it was possible to test the applicability of the Colombian model using a set of Portuguese operators, and draw some conclusions. The emphasis was put on the efficiency component included in pricing formulas, because the incentives for continuous improvement seem to be one of the main aspects to improve in the Portuguese regulatory model.
Bahn, Yong-Sun. „The role of the cyclic AMP-signaling pathway in morphogenic transitions, resistance to stresses, and virulence of Candida albicans“. The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054647894.
Der volle Inhalt der QuelleSelke, Kristin [Verfasser], André [Akademischer Betreuer] Bleich und Inga [Akademischer Betreuer] Brüsch. „Charakterisierung der Kandidatengene Bcl2l15, Slc30a7, Pde5a und Ifi44 für chronisch entzündliche Darmerkrankungen im Tiermodell der Interleukin-10-defizienten Maus / Kristin Selke ; André Bleich, Inga Brüsch“. Hannover : Stiftung Tierärztliche Hochschule Hannover, 2021. http://d-nb.info/123768479X/34.
Der volle Inhalt der QuelleMo, Weilan. „Human heart β-adrenoceptors, arrhythmias and control by phosphodiesterases“. Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/125160/1/Weilan%20Mo%20Thesis.pdf.
Der volle Inhalt der QuelleHwang, Yueh-Fei, und 黃月妃. „Miture Design Approach to PEA-PDEA-PTEA Ternary Polyol-Based Waterborne Polyurethane“. Thesis, 1997. http://ndltd.ncl.edu.tw/handle/18712634864229720547.
Der volle Inhalt der QuelleYu, Yu Tzu, und 尤鈺慈. „The Role of High Affinity Phosphodiesterase PDE2 in Mitochondria of Senescent Yeast Cells“. Thesis, 2015. http://ndltd.ncl.edu.tw/handle/67669496516808463452.
Der volle Inhalt der Quelle國立清華大學
生物科技研究所
103
Mitochondria are dynamic organelles that continuously undergo fusion and fission. Mitochondrial dynamics is important for maintaining mitochondrial integrity and cellular function. Aging is a degenerative process that exhibit physiological and mitochondrial dysfunction. Previous studies of our lab revealed mitochondrial fragmentation was present in senescent yeast cells. Resveratrol, a polyphenol mitigated mitochondrial fragmentation and superoxide level. In addition, resveratrol elevated membrane potential in the senescent yeast cells. However, the mechanism of how resveratrol-mediated mitochondria in senescent yeast cells remains unclear. We aim to elucidate the potential mechanisms. Previous studies indicated resveratrol can ameliorate aging-related metabolic phenotypes via inhibiting phosphodiesterase activity. In this thesis, I applied biotin-streptavidin system to isolate replicative senescent yeast cells to clarify the effect of phosphodiesterase, Pde2 on mitochondria. My results demonstrated that deletion of PDE2 reverted the effects of resveratrol on mitochondria dynamics and showed different transcription level of fission/ fusion genes. In the mitochondrial activity assay, resveratrol did not mitigate the superoxide level in Δpde2 senescent cells. Those results indicated that Pde2 is required for resveratrol-mediated mitochondrial dynamics and superoxide scavenging. These evidences provide hints to elucidate resveratrol signaling pathway in the regulation of mitochondrial dynamics in cellular senescence.
Po-Hsuan und 陳博玄. „Tongkat Ali (Eurycoma longifolia) decrease the PDE5A gene expression and enhance the NO and cGMP concentration of the plasma“. Thesis, 2009. http://ndltd.ncl.edu.tw/handle/48108866942795387684.
Der volle Inhalt der Quelle中山醫學大學
醫學研究所
97
Eurycoma longifolia (Tongkat Ali) is a plant with folk medicine in Indonesia, Malaysia, Thailand and Vietnam. The residences in Malaysia usually treat it as “ginseng of Malaysia”, and think it possesses multiple medical functions such as anti-hypertension and appetite stimulation. The purpose of this project was to examine the effect of E. longifolia extract on plasma NO and cGMP concentration in mice. Viagra was also used for comparison. Mice were treated by E. longifolia, Viagra, L-Arginine, Tongkat Ali plus ginseng, Dioscorea for 2 and 4 weeks. Plasma NO, cGMP level and the activity of type 5 phophodiesterase and cytochrome P450 were analyzed. Results showed that 5 treatments increased the NO and cGMP levels, and inhibited the activity of type 5 phophodiesterase. Tongkat Ali and Tongkat Ali plus ginseng treated mice at 4 weeks has significantly higher cytochrome P450 mRNA expression. These treatments did not affect the anti-oxidative defense in liver and kidney. These findings implied that Tongkat Ali could provide protective or medical functions via elevating plasma NO and cGMP concentration and decreasing PDE5 enzyme activity.
Lämmle, Simon. „Die Rolle der Phosphodiesterase 2 im Herzen“. Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-994E-0.
Der volle Inhalt der QuelleRood, Keith L. „Novel Adaptor-Dependent Domains Promote Processive Degradation by ClpXP“. 2011. https://scholarworks.umass.edu/theses/713.
Der volle Inhalt der QuelleEmons, Julius. „Rolle der Phosphodiesterase 2 in der menschlichen und experimentellen Herzinsuffizienz“. Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3F03-1.
Der volle Inhalt der QuelleSantos, João Filipe Delgado dos. „Regulation of CFTR trafficking and membrane anchoring : new insights into cAMP signalling“. Doctoral thesis, 2019. http://hdl.handle.net/10451/42281.
Der volle Inhalt der QuellePrograma doutoral BioSys - Sistemas Biológicos, Genômica Funcional & Integrativa (FCT / PD/ 00065 / 2012) da Faculdade de Ciências da Universidade de Lisboa
Perera, Ruwan K. „Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease“. Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-9936-4.
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