Auswahl der wissenschaftlichen Literatur zum Thema „PDE2A“
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Zeitschriftenartikel zum Thema "PDE2A"
Skryabin, Egor B., Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin und Viacheslav O. Nikolaev. „CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms“. Cells 12, Nr. 11 (04.06.2023): 1543. http://dx.doi.org/10.3390/cells12111543.
Der volle Inhalt der QuelleIvey, F. Douglas, Lili Wang, Didem Demirbas, Christina Allain und Charles S. Hoffman. „Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases“. Journal of Biomolecular Screening 13, Nr. 1 (26.11.2007): 62–71. http://dx.doi.org/10.1177/1087057107312127.
Der volle Inhalt der QuelleManns, J. M., K. J. Brennan, S. B. Sheth und R. W. Colman. „Differential Regulation of Human Platelet Responses by cGMP Inhibited and Stimulated cAMP Phosphodiesterases“. Thrombosis and Haemostasis 87, Nr. 05 (2002): 873–79. http://dx.doi.org/10.1055/s-0037-1613099.
Der volle Inhalt der QuelleCarvalho, Thays Maria da Conceição Silva, Silvia Cardarelli, Mauro Giorgi, Andrea Lenzi, Andrea M. Isidori und Fabio Naro. „Phosphodiesterases Expression during Murine Cardiac Development“. International Journal of Molecular Sciences 22, Nr. 5 (05.03.2021): 2593. http://dx.doi.org/10.3390/ijms22052593.
Der volle Inhalt der QuelleChen, Ling, Suying Cui, Haiyang Yu, Gaowen Li, Na Liu, Qiang Wu, Han-Ting Zhang, James M. O’Donnell, Gang Wang und Ying Xu. „Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice“. Journal of Psychopharmacology 33, Nr. 5 (05.03.2019): 568–76. http://dx.doi.org/10.1177/0269881119832753.
Der volle Inhalt der QuelleChen, Lin, Jinchi Zhou, Zifeng Zhao, Yuhan Zhu, Jinliang Xing, Jiaze An und Xu Guo. „Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma“. Cells 12, Nr. 1 (23.12.2022): 68. http://dx.doi.org/10.3390/cells12010068.
Der volle Inhalt der QuelleBarbagallo, Federica, Valentina Rotilio, Maria Rita Assenza, Salvatore Aguanno, Tiziana Orsini, Sabrina Putti, Andrea M. Isidori et al. „PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis“. International Journal of Molecular Sciences 21, Nr. 8 (21.04.2020): 2902. http://dx.doi.org/10.3390/ijms21082902.
Der volle Inhalt der QuelleMatthiesen, Karina, und Jacob Nielsen. „Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity“. Biochemical Journal 423, Nr. 3 (12.10.2009): 401–9. http://dx.doi.org/10.1042/bj20090982.
Der volle Inhalt der QuelleRitawidya, Ludwig, Briel, Brust und Scheunemann. „Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[e]imidazo[2,1-c][1,2,4]triazines as Phosphodiesterase 2A Inhibitors“. Molecules 24, Nr. 15 (31.07.2019): 2791. http://dx.doi.org/10.3390/molecules24152791.
Der volle Inhalt der QuelleRentsendorj, Otgonchimeg, Mahendra Damarla, Neil R. Aggarwal, Ji-Young Choi, Laura Johnston, Franco R. D'Alessio, Michael T. Crow und David B. Pearse. „Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury“. American Journal of Physiology-Lung Cellular and Molecular Physiology 301, Nr. 2 (August 2011): L161—L170. http://dx.doi.org/10.1152/ajplung.00073.2011.
Der volle Inhalt der QuelleDissertationen zum Thema "PDE2A"
Lobo, Miguel Gonçalo de Oliveira Jones Ferrão. „Role of PDE2A in cAMP/PKA signaling compartmentalization“. Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:e647c600-48e4-4222-85e7-019f91745608.
Der volle Inhalt der QuelleDelhaye, Sébastien. „Rôle de la phosphodiestérase 2A dans la physiopathologie du syndrome de l’X fragile“. Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6014.
Der volle Inhalt der QuelleFragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID). In addition to ID, patients might exhibit autistic features, hyperactivity and attention-deficit disorder, language dysfunction and seizures. Approved and effective therapies are not yet available for FXS. The main hallmark of FXS in the brain is the presence of immature and denser dendritic spines. This abnormality is associated with altered synaptic plasticity in our animal model of FXS, the Fmr1-KO mice. FXS is caused by a CGG repeat expansion with a number of repeats higher than 200 in the 5’UTR of the Fragile X Mental Retardation 1 (FMR1) gene. Methylation of this region and of its surrounding sequences, including the promoter of FMR1, results into the silencing of the gene and the loss of its encoded protein, FMRP. An expansion with a number of repeats variable between 50 and 200 is considered as a premutation and is associated with two pathological conditions other than FXS: the Fragile X-associated Tremor Ataxia Syndrome (FXTAS), and the Fragile Xassociated Primary Ovarian Insufficiency (FXPOI). FMRP is an RNA-binding protein implicated in various steps of RNA metabolism. In particular, it plays a role in the translational regulation of a subset of synaptic proteins. We showed that FMRP modulates the synaptic expression of Phosphodiesterase 2A (PDE2A), an enzyme implicated in the degradation of cAMP and cGMP. In. the absence of FMRP, the levels and the activity of PDE2A are increased, and, consequently, cAMP/cGMP levels are reduced in the cortex and hippocampus of Fmr1-KO mice. The blockade of PDE2A with a specific and powerful inhibitor of PDE2A, Bay 607550, rescues various in vitro, ex vivo and in vivo FXS phenotypes. In particular, I contributed to this study by showing that the treatment with Bay 60-7550 rescues social deficits in young and adolescent Fmr1-KO mice and abnormal dendritic spine morphology in hippocampus. In order to validate this new therapeutic target for FXS, I crossed Pde2a+/- mice with Fmr1-KO mice and analyzed their behavior, neuronal morphology and signaling pathways linked to cAMP/cGMP levels in the hippocampus and cortex. I found that double mutant animals (Fmr1-KO x Pde2a+/-) have a normal social and cognitive behavior compared to both Fmr1-KO and Pde2a+/- mice. Indeed, Pde2a+/- mice display behavioral deficits similar to those characterizing the Fmr1-KO mouse, even if the molecular alterations seem to be opposite. In conclusion, my results highlight the key role of PDE2A-dependent cAMP and cGMP levels and their correlated pathways in neurodevelopment. Furthermore, in addition to my main project, in the first part of my doctoral stage, I participated to the characterization of neuronal morphology in the mice model of FXTAS showing that this neurodevelopmental marker is dependent on the level of the Fmr1 mRNA, which displays elevated levels in these mice in the presence of the Fmr1 premutation
Law, Robert. „PDE3A signalling in blood platelets“. Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13761.
Der volle Inhalt der QuelleWilson, Moira Ann. „Characterisation and analysis of PDE4A phosphodiesterase isoforms“. Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307182.
Der volle Inhalt der QuelleJohnston, Lee Ann. „The investigation of two novel PDE4A enzymes“. Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400759.
Der volle Inhalt der QuelleLivie, Craig. „Determining the role of PDE2 within the mitochondria“. Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6683/.
Der volle Inhalt der QuelleBegg, Fiona A. „Cloning and biochemical characterisation of two novel PDE4A cAMP phosphodiesterases“. Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394925.
Der volle Inhalt der QuelleSekharan, Monica R. „Structural studies of the cGMP-binding GAF domain of PDE5A /“. Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.
Der volle Inhalt der QuelleErcu, Maria [Verfasser]. „Molecular mechanisms underlying PDE3A-caused hypertension with brachydactyly (HTNB) / Maria Ercu“. Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1222513862/34.
Der volle Inhalt der QuelleLounas, Amel. „Fonction et localisation de la PDE8A dans les cellules ovariennes porcines et son implication dans la stéroïdogenèse“. Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27731.
Der volle Inhalt der QuelleBücher zum Thema "PDE2A"
Sewell, Granville. Solving Partial Differential Equation Applications with PDE2D. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781119507918.
Der volle Inhalt der QuelleSewell, Granville. Solving Partial Differential Equation Applications with PDE2D. Wiley & Sons, Limited, John, 2018.
Den vollen Inhalt der Quelle findenSewell, Granville. Solving Partial Differential Equation Applications with PDE2D. Wiley & Sons, Incorporated, John, 2018.
Den vollen Inhalt der Quelle findenSewell, Granville. Solving Partial Differential Equation Applications with PDE2D. Wiley, 2018.
Den vollen Inhalt der Quelle findenSewell, Granville. Solving Partial Differential Equation Applications with PDE2D. Wiley & Sons, Incorporated, John, 2018.
Den vollen Inhalt der Quelle findenBuchteile zum Thema "PDE2A"
Lobo, Miguel J., und Manuela Zaccolo. „PDE2A“. In Encyclopedia of Signaling Molecules, 3826–34. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101603.
Der volle Inhalt der QuelleLobo, Miguel J., und Manuela Zaccolo. „PDE2A“. In Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101603-1.
Der volle Inhalt der QuelleZahid, Sarwar, Kari Branham, Dana Schlegel, Mark E. Pennesi, Michel Michaelides, John Heckenlively und Thiran Jayasundera. „PDE6A“. In Retinal Dystrophy Gene Atlas, 175–76. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-10867-4_54.
Der volle Inhalt der QuellePetersen-Jones, Simon M., Laurence M. Occelli, Martin Biel und Stylianos Michalakis. „Advancing Gene Therapy for PDE6A Retinitis Pigmentosa“. In Retinal Degenerative Diseases, 103–7. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27378-1_17.
Der volle Inhalt der QuellePardasani, R. T., und P. Pardasani. „Effective magnetic moment of [Co(pdea)2(BF4)2]⋅4H2O“. In Magnetic Properties of Paramagnetic Compounds, 3392. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_3057.
Der volle Inhalt der QuelleMeins, M., A. Janecke, C. Marschke, M. J. Denton, G. Kumaramanickavel, S. Pittler und A. Gal. „Mutations in PDE6A, the Gene Encoding the α-Subunit of Rod Photoreceptor Cgmp-Specific Phosphodiesterase, are Rare in Autosomal Recessive Retinitis Pigmentosa“. In Degenerative Retinal Diseases, 237–44. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5933-7_26.
Der volle Inhalt der QuellePierce, Kenneth E., Paul G. Curran, Christopher P. Zelinka, Andy J. Fischer, Simon M. Petersen-Jones und Joshua T. Bartoe. „Sildenafil Administration in Dogs Heterozygous for a Functional Null Mutation in Pde6a: Suppressed Rod-Mediated ERG Responses and Apparent Retinal Outer Nuclear Layer Thinning“. In Retinal Degenerative Diseases, 371–76. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27378-1_61.
Der volle Inhalt der Quelle„Introduction to PDE2D“. In Solving Partial Differential Equation Applications with PDE2D, 1–20. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781119507918.ch0.
Der volle Inhalt der QuelleMartinez, Sergio E. „PDE2 Structure and Functions“. In Cyclic Nucleotide Phosphodiesterases in Health and Disease, 55–77. CRC Press, 2006. http://dx.doi.org/10.1201/9781420020847-4.
Der volle Inhalt der QuelleMartinez, Sergio. „PDE2 Structure and Functions“. In Cyclic Nucleotide Phosphodiesterases in Health and Disease. CRC Press, 2006. http://dx.doi.org/10.1201/9781420020847.ch4.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "PDE2A"
Doummar, D., C. Dentel, V. Bouilleret, B. Dozieres-Puyravel, H. Nasser, E. Hirsch, C. Mignot und G. Rudolf. „Biallelic PDE2A Mutations: A New Cause of Intellectual Disability with Paroxysmal Dyskinesia and/or Epilepsy“. In Abstracts of the 47th Annual Meeting of the SENP (Société Européenne De Neurologie Pédiatrique). Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1685434.
Der volle Inhalt der QuelleRentsendorj, Otgonchimeg, Franco D'Alessio, Aigul Moldobaeva, Y. Eto und David B. Pearse. „LPS Induced INOS Expression Is Negatively Regulated By Phosphodiesterase 2A (PDE2A) In Lung And Peritoneal Macrophages“. In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5062.
Der volle Inhalt der QuelleRentsendorj, Otgonchimeg, Mahendra Damarla, Michael T. Crow, Ji-Young Choi, Franco D'Alessio und David B. Pearse. „Phosphodiesterase 2A (PDE2A) Upregulates Inducible Nitric Oxide Synthase (INOS) In Lung Injury From Intra-Tracheal LPS And Large Tidal Volume Ventilation In Mice“. In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2107.
Der volle Inhalt der QuelleWu, Xiaoyun, Timothy Lewis, Luc de Waal, Galen Gao, Jian Zhang, Monica Schenone, Colin Garvie et al. „Abstract 2028: PDE3A modulation for cancer therapy“. In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2028.
Der volle Inhalt der QuelleLi, Gang, und Songqi Huang. „PDEA target weight determination methods based on GRA / AHP“. In 2009 IEEE International Conference on Grey Systems and Intelligent Services (GSIS 2009). IEEE, 2009. http://dx.doi.org/10.1109/gsis.2009.5408342.
Der volle Inhalt der QuelleTergau, Katharina, Moritz Gröner, Rebecca Firneburg, Eleder Cachorro, Mario Günscht, Kevser Kocas, Carolin Richter, Ali El-Armouche und Susanne Kämmerer. „The cGMP-induced PDE2 stimulation as a novel antiarrhythmic strategy“. In cGMP: Generators, Effectors and Therapeutic Implications. ScienceOpen, 2024. http://dx.doi.org/10.14293/cgmp.000015.v1.
Der volle Inhalt der QuelleTergau, Katharina, Moritz Gröner, Rebecca Firneburg, Eleder Cachorro, Mario Günscht, Kevser Kocas, Carolin Richter, Ali El-Armouche und Susanne Kämmerer. „The cGMP-induced PDE2 stimulation as a novel antiarrhythmic strategy“. In cGMP: Generators, Effectors and Therapeutic Implications. ScienceOpen, 2024. http://dx.doi.org/10.14293/cgmp.24000073.v1.
Der volle Inhalt der QuelleWu, Xiaoyun, Malvina Papanastasiou, Gavin Schnitzler, Colin Garvie, Stephanie Hoyt, Terry Zhang, James Mullahoo et al. „Abstract 1219: Deep mutational scanning of PDE3A identifies residues required for DNMDP response“. In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1219.
Der volle Inhalt der QuelleHou, Qingfeng, Xiaobo Zheng, Donghong Guo, Youyi Zhu, Hui Yang, Xingguang Xu, Yuanyuan Wang, Gang Chen, Guangxin Hu und Jinben Wang. „PDEA-Based Amphiphilic Polymer Enables pH-Responsive Emulsions for a Rapid Demulsification“. In SPE International Conference on Oilfield Chemistry. Society of Petroleum Engineers, 2019. http://dx.doi.org/10.2118/193640-ms.
Der volle Inhalt der QuelleJiao, Ai-Ying, und Jun-Hai Ma. „An Empirical Research of Bohai Rim Container Terminal Based on PDEA Model“. In 2008 4th International Conference on Wireless Communications, Networking and Mobile Computing (WiCOM). IEEE, 2008. http://dx.doi.org/10.1109/wicom.2008.1610.
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