Thematische Bibliographien / Pagents

Auswahl der wissenschaftlichen Literatur zum Thema „Pagents“

Autor: Grafiati
Veröffentlicht am 27. Juli 2024
Zuletzt aktualisiert am 29. Juli 2024

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Zeitschriftenartikel zum Thema "Pagents"

1

Twardy, Chuck. „Pagers, Pageants and Powwows“. Afterimage 26, Nr. 6 (Mai 1999): 17. http://dx.doi.org/10.1525/aft.1999.26.6.17.

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2

Mantovani, Giulia, Anna Fagotti, Massimo Franchi, Giovanni Scambia und Giorgia Garganese. „Reviewing vulvar Paget’s disease molecular bases. Looking forward to personalized target therapies: a matter of CHANGE“. International Journal of Gynecologic Cancer 29, Nr. 2 (23.01.2019): 422–29. http://dx.doi.org/10.1136/ijgc-2018-000080.

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ObjectivesTo review the published literature on vulvar Paget’s disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.MethodsMEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessment on the basis of the relevance and contribution to the selected topics.ResultsA total of 42 studies were selected, providing the following results. Molecular markers implicated in cell cycle transitions seem to be related to prognosis and could help to tailor conventional treatments. Fragmented but consistent preliminary data exist on hormonal receptor expression, ERBB2 amplification/overexpression and abnormal vascular proliferation, offering a concrete possibility for target therapy trials. Conversely, other fields linked to the possible use of immunotherapy are currently relatively unexplored, such as the tumor 'immune contexture', programmed death ligand-1 (PD-L1) expression and defects in the mismatch repair system, which is involved in genomic instability and potentially promotes a consistent response to treatment.ConclusionsAdditional effort is needed to further characterize these aspects. Centralization of patients in dedicated units would be beneficial for concentrating patient numbers, collecting valuable clinical data and conducting clinical trials. Interdisciplinary study platforms should be developed and integrated into wider multicentric networks.
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Ziyanak, Sebahattin, und Steve Aicinena. „Native American Princess Pageants and Their Role in Maintaining Tribal Cultures“. Great Plains Research 34, Nr. 1 (März 2024): 25–43. http://dx.doi.org/10.1353/gpr.2024.a933408.

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Abstract: This study employs qualitative fieldwork experiences to assess the role of Native American princess pageants in maintaining tribal cultures and Native American identity. We first defined and described the term “princess” and the institution that is the Native American princess pageant. After completing an extensive literature review of beauty contests, Native American culture, Native American history, and Native American pageants, we developed seven themes and seven subthemes accounting for the role of the Native American princess pageant in the maintenance of tribal cultures. We employed participant observation to collect data over 28 hours of activities related to the public 2022 Miss Indian World pageant and the Gathering of Nations powwow, which included the introduction of the pageant contestants and crowning of the 2022 Miss Indian World. We focused on performances of culture and verbal depictions of culture. Our findings aligned with the seven themes and seven subthemes derived from our literature review and supported the role of the Native American princess pageant in maintenance of tribal and pantribal cultures.
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Khan, Shana Makhmood, und Suprayogi Suprayogi. „SCHEMATIC STRUCTURE AND METADISCOURSE ANALYSIS OF BEAUTY PAGEANT-WINNING ANSWERS“. JOURNAL OF LANGUAGE 6, Nr. 1 (22.05.2024): 112–24. http://dx.doi.org/10.30743/jol.v6i1.9104.

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This research delves into the schematic structure and metadiscourse markers utilized in the winning responses of prominent Beauty Pageants. Through qualitative investigation, it explores how candidates strategically organize their answers and employ language to effectively convey their perspectives. Drawing upon theoretical frameworks from schematic structure theory and metadiscourse classification, the study analyzes transcripts of final question and answer segments from Beauty Pageant events spanning from 2015 to 2023. Utilizing 36 transcribed texts sourced from YouTube archives and transcription, the study sheds light on the nuanced structure of responses, highlighting patterns in linguistic expression. Despite the extensive data from Beauty Pageants, differences in format and accessibility across events were observed. This study contributes to understanding the intricacies of communication within beauty pageants, elucidating the structural elements of successful responses. Ultimately, it advances our comprehension of pageant competitions on both large and small scales. Furthermore, this research provides valuable insights for individuals interested in participating in beauty pageants, offering guidance on the effective use of metadiscourse markers for practice and application.
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Anja, Kerschen, Dano Hélène, Van Eeckhout Pascal, Marot Liliane und Van Bockstal Mieke. „Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!“ International Journal of Surgical Pathology 29, Nr. 6 (22.03.2021): 631–34. http://dx.doi.org/10.1177/10668969211002920.

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Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.
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Reid, Ellie. „Dressing the Pageanteers: The Local People and Theatre Professionals who Costumed Edwardian Historical Pageants“. Costume 58, Nr. 1 (März 2024): 21–47. http://dx.doi.org/10.3366/cost.2024.0285.

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The craze for historical pageants staged in Britain by local communities at the beginning of the twentieth century stimulated a widespread public engagement with historical costume. As well as thousands of performers, and tens of thousands of spectators, pageants involved hundreds of local people in sewing parties who spent months making the costumes required for these outdoor re-enactments of episodes of local history. This article investigates how pageant costumes were designed, made or sourced, on the large scale required, and the cost implications this involved. Whilst costume designers were acknowledged, the employment of professional dressmakers and milliners often necessary to complete the work received less recognition. Florence Edwards, a professional theatrical dressmaker, is one of the few who can be identified. The role of the London theatrical costumier Willie Clarkson, a supplier to many pageants, is also examined. During pageant preparations, local people actively researched dress history, and in the case of Emily Ashdown her interest led to a lifelong career as a dress historian.
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Shrestha, Tara Lal. „Body Politics in Beauty Pageants: A Study of Miss Nepal Discourse“. SCHOLARS: Journal of Arts & Humanities 5, Nr. 1 (15.02.2023): 1–15. http://dx.doi.org/10.3126/sjah.v5i1.52470.

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The paper attempts to explore how the female body is often controlled by the power politics, which is discussed with reference to the Miss Nepal beauty pageant. The pageant being organized since 1994 has drawn not only ideological and ethical debate, but it has also generated street demonstrations including violent confrontations since then. Though women’s wings of various politico-cultural organizations tried to stop it by organizing various protest movements, multiple forms of regional and community-based beauty pageants are proliferating in Nepal. This study primarily tries to observe the forms of body politics that exist in Miss Nepal beauty contests from the perspective of indigenous aesthetics. Secondly, it analyzes how the female body is tied with the power politics in the name of beauty pageants from the Gramscian notion of ‘hegemony’ and Ngugi wa Thiongo’s ‘decolonizing the mind’. Finally, as indigenous aesthetics is an extensive domain, this paper recommends some ways to deal with the Miss Nepal beauty pageant issues, especially with reference to the indigenous Newa: women aesthetics.
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Tourangeau, Rémi, und Marcel Fortin. „Le Phénomène des pageants au Québec“. Theatre Research in Canada 7, Nr. 2 (Januar 1986): 215–38. http://dx.doi.org/10.3138/tric.7.2.215.

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Essai de définition et typologie des pageants québécois à la lumière de la tradition du pageant primitif et de l'histoire du pageant moderne en Grande Bretagne et aux Etats-Unis. Cet article tente de situer un phénomène à partir des caractéristiques de l'utilisation de l'histoire et de la composition de la dramaturgie. Il fournit notamment les principaux critères de l'authenticité et de l'originalité de ce genre de spectacles québécois.
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Bae, Soo Youn, Ji Eun Lee, Woo-Chan Park, Chang Ik Yoon, Dooreh Kim, Kabsoo Shin und Youngjoo Lee. „Clinical subtypes and survival outcomes in invasive breast cancer with Paget’s disease: A SEER population-based study.“ Journal of Clinical Oncology 41, Nr. 16_suppl (01.06.2023): e12564-e12564. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e12564.

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e12564 Background: The objective of this study was to investigate the clinicopathological characteristics, especially subtypes and survival outcomes of Invasive breast cancer with Paget's disease. Methods: 4930 patients were identified using the histopathology codes from the International Classification of Disease for Oncology third edition (ICD-O-3), from 2000 to 2019 in the Surveillance, Epidemiology, and End Results (SEER) database. Excluding 787 patients whose ICD-O-3 and TNM stages did not match, there were 663 patients with '8540/3, Paget disease, mammary', 976 patients with ‘8543/3, Paget disease and intraductal carcinoma(DCIS)’ and 2540 patients with ‘8541/3, and ‘8541/3, Paget disease and infiltrating ductal carcinoma (IDC) of breast’. ER and PR status have been available since 1990, and HER2 status since 2010. Results: Among patients with IDC and Paget's disease, 24.6% were under the age of 50 and 2.7% were male, which was higher than the other two groups. Expressions of ER and PR were higher than both groups, and HER2 expression was lower. The ratio of HR-/HER2+ subtype was also lower than the other two groups at 29.6%. ER+, Paget 43.7%, DCIS with Paget 36.4%, IDC with Paget 53.6%. PR+ Paget 21.6%, DCIS with Paget 21.7%, IDC with Paget 40.1%. HER2+ Paget 69.2%, DCIS with Paget 83.1 %, IDC with Paget 58.3%. HR-/HER2+subtype, Paget 40.7%, DCIS with Paget 49.2%, IDC with Paget 29.6%. As a result of survival analysis in patients with IDC and Paget's disease, the HR-/HER2+ subtype had shown the best prognosis in Overall Survival (OS) analysis (5year OS, HR+/HER2- 70.8%, HR+/HER2+ 74.9%, HR-/HER2- 63.7%, HR-/HER2+ 80.7% P=0.010) In the BCSS analysis, the 5-year BCSS was the best at 87.0% in the HR-HER2+ subtype, but there was no statistically significant difference. Conclusions: In IDC with Paget's disease, the distribution of subtypes is different from that of DCIS with Paget's, and HER2 expression can be considered as a favor prognostic factor. It is considered necessary to study the relationship between the loss of HER2 overexpression and invasion/progression in invasive breast cancer with Paget's disease.
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Havird, David. „Pageants“. Sewanee Review 115, Nr. 3 (2007): 331–34. http://dx.doi.org/10.1353/sew.2007.0073.

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Dissertationen zum Thema "Pagents"

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Williams, Caroline. „It's Not a Beauty Pageant!: An Examination of Leadership Development through Alaska Native Pageants“. Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293488.

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This dissertation explores the adaptation of traditionally objectified women's spaces, into an arena for leadership development, research which incorporates the development of culturally relevant mechanisms of leadership training within Indigenous societies. Cultural pageants offer a place for young women to become spokespersons on social justice issues, without the sexual objectification of entering beauty pageants. Such pageants also provide a glimpse of how cultural groups wish their national identity to be portrayed to the general public. Fifty years in the making, today's Native Nations cultural pageants have been decolonized to present images of young leaders, confident in their heritage, introducing themselves in their Native language, and committed to cultural continuity and sustainable Nations. This research examines a state-wide Alaska Native pageant, Miss World Eskimo Indian Olympics, from three perspectives: 1) The young women who develop culturally based leadership skills; 2) The community, who gains language and cultural, revitalization and maintenance role models; 3) And the general public, who gains a much needed positive representation of a contemporary Indigenous women. This study draws from interdisciplinary theories and research methodologies (including observation, in-depth interviews, questionnaires, surveys, and archival research) and follows the young women through to the contest at the national level, Miss Indian World, run annually in Albuquerque, through Gathering of Nations. The underlying hypothesis is that women use cultural pageants as a stepping stone to advance their cultural leadership. In doing so, they promote factors of community well-being affecting Indigenous communities, such as suicide prevention, substance abuse, and language and cultural revitalization.
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Andrade, José Costa de [UNESP]. „Perfil imunoistoquímico do carcinoma de Paget da mama“. Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/103714.

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Made available in DSpace on 2014-06-11T19:32:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2004Bitstream added on 2014-06-13T19:22:31Z : No. of bitstreams: 1 andrade_jc_dr_botfm.pdf: 2650759 bytes, checksum: 3247fedde23c0a35497a64d9285fa833 (MD5)
Universidade Estadual Paulista (UNESP)
O objetivo deste trabalho foi estudar através do exame Imunoistoquimico, a correlação entre alguns fatores Anatomopatológicos (tipo histológico e grau nuclear) e alguns fatores biológicos (receptores hormonais de estrógeno e de progesterona, proteína c-erbB-2 e proteína p53, no carcinoma de Paget da mama, doença rara e especial. No período entre Janeiro de 1980 a Dezembro de 1998 foram tratados no Instituto Brasileiro de Controle do Câncer, 6.303 casos de câncer de mama, deste total 98 casos foram diagnosticados como carcinoma de Paget, cuja incidência foi de 1,55%. Estudamos retrospectivamente 60 casos, sendo que 38 deles foram excluídos da análise, devido a limitação e escassez da amostra no material disponível, a idade das pacientes variou entre 26 e 84 anos, com média de 55,4 anos, as informações clínicas e terapêuticas foram obtidas dos prontuários das pacientes considerando, idade na época do diagnóstico, tamanho do tumor quando palpável, estadiamento clínico, e o tipo de cirurgia realizada. As amostras de tecido mamário foram recuperadas dos arquivos do Departamento de Anatomia Patológica do I.B.C.C. / MATTOSINHO. Após a revisão histológica, realizada por dois patologistas os casos foram classificados em quatro grupos: Grupo A- Doença de Paget (forma pura) n = 09 Grupo B- Doença de Paget + neoplasia ductal “in situ”, n = 12 Grupo C- Doença de Paget, neoplasia ductal invasora, n = 30 Grupo D- Doença de Paget + neoplasia ductal “in situ”+ neoplasia ductal invasora, n = 09. Entre as variáveis anatomopatológicas, o grupo C prevaleceu com 30 casos (50%). O grau nuclear (GN-II) predominou com 45 casos (75%). Em relação as variáveis biológicas o receptor de estrógeno negativo predominou com 41 casos (68,3%), seguido pelo receptor de progesterona negativo com 40 casos (66,7%), podemos dizer que...
The objective of this paper was to study the immunohistochemical efects of Paget’s disease, a rare and special carcinoma of the breast, by correlating anatomopathological (histological and nuclear grade) and biological (estrogen and progesterone hormonal receptors, c-erbB-2 protein and p53 protein) factors. Between January 1980 and December 1998, 6303 cases of breast cancer were treated at the Brazilian Institute of Cancer Control; 98 of these were diagnosed with Paget’s carcinoma, an incidence of 1.55%. We retrospectively studied 60 of these cases; 38 were excluded due to lack of available sample material. Patient age varied between 26 and 84 years (mean 55.4), clinical and therapeutic information were obtained from patient’s medical records considering age at time of diagnosis, tumor size when palpable, clinical stage, and type of surgery performed. Samples of breast tissue were retrieved the Anatomical Pathology Department, I.B.C.C. / MATTOSINHO. After histological review, by two different pathologists, they were classified into four groups: Group A- Paget’s disease (pure form) n = 09 Group B- Paget’s disease + “in situ” duct neoplasia n = 12 Group C- Paget’s disease, invasive duct neoplasia n = 30 Group D- Paget’s disease + “in situ” duct neoplasia + invasive duct neoplasia n = 09.Invasive duct neoplasia was the most prevalent anatomopathological variable (Group C, n = 30, 50%). Nuclear grade (GNII) was found in 45 cases (75%). In relation to the biological variables, the negative estrogen receptor was predominant with 41 cases (68.3%), followed by the negative progesterone receptor with 40 cases (66.7%); this correlation had good concordance by the Kappa test. The c-erbB-2 protein was positive in 53 cases (88.3%) and p53 was negative in 47 cases (78.3%). From these results, we concluded that there was no statistical... (Complete abstract click electronic address below)
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Lewis, Heidi D. ?UNAUTHORIZED. „"Speaking out of the dust" : religious reenactments with the specific iconic identity of place /“. Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1478.pdf.

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4

Amilibia, Cabeza Emilio. „Caracterización de la hipoacusia en la enfermedad de Paget“. Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664352.

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Introducción y objetivos: La enfermedad ósea de Paget (EOP) puede cursar con hipoacusia. Con el objetivo de cuantificar, caracterizar, determinar los factores de riesgo de hipoacusia y analizar las posibles relaciones de la hipoacusia con los hallazgos tomográficos en un grupo de pacientes con EOP, se realiza el presente estudio. Métodos: Se realizó un estudio observacional, transversal del tipo casos y controles que incluyó una cohorte de 76 sujetos con diagnóstico de enfermedad ósea de Paget (EOP) en el grupo caso y un grupo control de 134 sujetos. Se analiza la información clínica, demográfica, audiométrica y radiológica, mediante una TC de hueso temporal, de los sujetos incluidos. Resultados: El análisis comparativo entre el grupo de sujetos con EOP y el grupo control determinó que el grupo caso presentaban un umbral medio auditivo mayor (39,51 dB) que en el grupo control (37,28 dB) (p=0,069) y que presentaba hipoacusia transmisiva con mayor frecuencia (22,76%) que el grupo control (12,05%) (p=0,0062). El análisis de los factores de riesgo de hipoacusia determinó que la afectación craneal en la gammagrafía ósea, la edad y la HTA entre otros, constituían factores de riesgo de mayor pérdida auditiva en EOP. El estudio tomográfico constató que los pacientes con EOP presentaban una menor densidad ósea en unidades Hounsfield (UH) en el peñasco del temporal respecto al grupo control. Así mismo se pudo observar que la densidad ósea en la cápsula ótica en pacientes con EOP se correlacionaba con el umbral auditivo tanto de vía aérea como de vía ósea (p<0,05) y que la presencia de un gap en la audiometría se correlacionaba con la afectación por hueso pagético del temporal. Conclusiones: - El 63,45% de los sujetos con enfermedad ósea de Paget (EOP) padecen hipoacusia, con un umbral auditivo medio de 39,51dB. - Los sujetos con enfermedad ósea de Paget (EOP) presentaron una pérdida auditiva más severa y con mayor frecuencia de tipo transmisivo que el grupo control. - Los sujetos con afectación de la calota craneal por EOP presentaron mayor pérdida auditiva que los sujetos sin afectación craneal. La afectación de la calota craneal por la EOP y la edad constituyeron factores de riesgo de hipoacusia. - En los sujetos con EOP el umbral auditivo tanto de vía aérea como ósea se relaciona con la disminución de densidad en la cápsula ótica.
Introduction and objectives: Paget’s disease of bone (PDB) may lead to hearing loss. The present study is conducted with the aim of measuring, characterizing, determining the risk factors for hearing loss and analyse the possible relation of hearing loss with tomography findings in a group of subjects with PDB. Methods: An observational, transversal, case-control study was conducted, a cohort of 76 subjects diagnosed of Paget’s disease of bone (PDB) in the case group and a control group of 134 subjects were included. Clinical, demographic, audiometric and tomographic data (by means of a CT scan study) were analysed. Results: The comparative analysis between the subjects in the PDB group and the control group found that the case group showed higher hearing thresholds (39,51dB) comparing with the control group (37,28 dB) (p=0,069) and presented a greater rate of conductive hearing loss (22,76%) than the control group (12,05%) (p=0,0062). The study of risk factors for hearing loss found that skull involvement in bone scintigraphy, age and high blood pressure were risk factors for higher hearing impairment in PDB. The CT scan data showed that subjects in the PDB group had lower temporal bone density (Hounsfield Units, HU) comparing with the control group. It was also found that the otic capsule bone density in the PDB group correlated with both the air and bone conduction hearing thresholds (p<0,05) and that the finding of an air-bone gap in the audiogram correlated with Paget’s disease temporal bone involvement. Conclusions: − The 63,45% of subjects with Paget’s disease of bone (PDB) suffer hearing loss with a hearing threshold of 39,51dB on average. − The subjects with PDB showed a deeper hearing loss and a higher proportion of conductive type than the control group. − The patients with PDB and skull involvement presented a more severe hearing loss compared with the subjects without skull involvement. Skull involvement and age were found to be risk factors for hearing loss. − In the PDB group both the air and bone conduction hearing thresholds correlated with the otic capsule bone density.
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Conesa, Mateos Arántzazu. „Caracterización clínica, epidemiológica y molecular de la enfermedad Ósea de Paget“. Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673198.

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La malaltia òssia de Paget (MOP) es caracteritza per ser un trastorn crònic i focal del remodelat ossi que comporta a l’aparició de complicacions com deformitats òssies, artropatia i fractures. La MOP presenta una gran variabilitat en la seva distribució en funció de l’edat, gènere, ètnia i àrea geogràfica. Recents estudis han descrit canvis seculars pel que fa a la prevalença, incidència i gravetat al diagnòstic de la MOP, mostrant una disminució en les últimes dècades. La MOP es considera actualment una malaltia multifactorial amb participació de factors ambientals i genètics. El gen que ha mostrat major susceptibilitat és el Sequestosoma1 (SQSMT1), les mutacions descrites en ell no explicarien de manera completa la patogènia de la MOP. En l’actualitat, són escassos els estudis sobre variacions genètiques en els gens TNFRSF11B i TNFRSF11A associats a MOP clàssica així com l’existència d’interaccions genètiques entre els dos gens i el gen SQSMT1, que condueixi a un increment de risc de MOP i fins i tot que influeixen en el seu fenotip. Amb la finalitat d’investigar el patró de comportament clínic-epidemiològic com genètic de la MOP de la nostra població de baixa prevalença, ens plantegem els següents objectius. Els objectius es van centrar en avaluar canvis en l’evolució del percentatge de nous diagnòstics de la MOP durant el període 1970-2009 i descriure en aquests pacients diferències pel que fa a la severitat al diagnòstic. Així com analitzar la importància d’alteracions moleculars en el gen SQSTM1 i la presència de variacions al·lèliques en els gens TNFRSF11B i TNFRSF11A, tant en la susceptibilitat per al desenvolupament de la MOP com la influència en el seu fenotip. Pacients i Mètodes: Estudi descriptiu ambispectiu observacional de pacients procedents de l’Hospital de la Mar-Parc de Salut Mar (Barcelona), una àrea de baixa prevalença. Es van incloure 393 pacients, diagnosticats entre 1970 i 2009. L’estudi molecular es va dur a terme mitjançant el genotipatge de les 21 variants polimòrfiques per a l’estudi dels gens TNFRSF11B i TNFRSF11A, així com la seqüenciació de el gen SQSTM1 en una població de 200 pacients afectes de MOP i 200 controls hipernormales. Resultats: En l’estudi s’observa un descens progressiu del percentatge del nous diagnòstics de MOP en relació a la població de referència, entre 1994 i 2009, més marcat en el grup de ≥ de 65 anys. Així mateix, s’ha constatat que els pacients afectes de MOP presenten una disminució en l’activitat biològica de la malaltia, una menor extensió de la malaltia i una major edat de presentació al diagnòstic, en funció de l’any de naixement i any del diagnòstic. En contraposició, s’ha observat major severitat en el moment del diagnòstic en els pacients amb edats al diagnòstic de <45 anys i ≥75 anys. S’han identificat 5 factors independents de mal pronòstic al diagnòstic, que afavoriran pitjors desenllaços. Pel que podem concloure, que en el moment de diagnòstic de MOP, l’expressió de la malaltia és menys severa i esdevé de forma més tardana. Els resultats de l’estudi molecular destaquen l’associació significativa entre els SNPs rs3018362 i rs1805034 del gen TNFRSF11A i rs11573871 del gen TNFRSF11B amb l’increment de risc de desenvolupar MOP així com la influència en el seu fenotip. Així mateix es va observar que la presència de l’al·lel T en el polimorfisme rs6567274 del gen TNFRSF11A es va associar amb una disminució de risc de desenvolupar la MOP, així com a un fenotip més lleu. En l’estudi molecular del gen SQSTM1 es van identificar 6 variants genètiques “missense” de nova descripció, associades amb una major susceptibilitat de desenvolupament de la MOP.
La enfermedad ósea de Paget (EOP) se caracteriza por ser un trastorno crónico y focal del remodelado óseo que conlleva a la aparición de complicaciones como deformidades óseas, artropatía por vecindad y fracturas. La EOP presenta una gran variabilidad en su distribución en función de la edad, género, etnia y área geográfica. Recientes estudios han descrito cambios seculares en cuanto a la prevalencia, incidencia y gravedad al diagnóstico de la EOP, mostrando una disminución en las últimas décadas. La EOP se considera actualmente una enfermedad multifactorial con participación de factores ambientales y genéticos. El gen que ha mostrado mayor susceptibilidad es el Sequestosoma1(SQSMT1), las mutaciones descritas en él no explicarían de forma completa la patogenia de la EOP. En la actualidad, son escasos los estudios acerca de variaciones genéticas en los genes TNFRSF11B y TNFRSF11A asociados a EOP clásica así como la existencia de interacciones genéticas entre ambos genes y el gen SQSMT1, que conduzca a un incremento de riesgo de EOP e incluso que influya en el fenotipo. Con la finalidad de investigar el patrón de comportamiento clínico-epidemiológico como genético de la EOP de nuestra población de baja prevalencia, nos planteamos los siguientes objetivos. Los objetivos se centraron en evaluar cambios en la evolución del porcentaje de nuevos diagnósticos de EOP durante el periodo 1970-2009 y describir en dichos pacientes diferencias en cuanto a la severidad al diagnóstico. Así como así como analizar la importancia de alteraciones moleculares en el gen SQSTM1 y la presencia de variaciones alélicas en los genes TNFRSF11B y TNFRSF11A, tanto en la susceptibilidad para el desarrollo de la EOP como la influencia en su fenotipo. Pacientes y Métodos: Estudio descriptivo ambispectivo observacional de pacientes procedentes del Hospital del Mar-Parc de Salut Mar (Barcelona), un área de baja prevalencia. Se incluyeron 393 pacientes, diagnosticados entre 1970 y 2009. En base al estudio molecular se llevó a cabo el genotipado de las 21 variantes polimórfica para el estudio los genes TNFRSF11B y TNFRSF11A, así como la secuenciación del gen SQSTM1 en una población de 200 pacientes afectos de EOP y 200 controles hipernormales. Resultados: En el estudio se observa un descenso progresivo del porcentaje de nuevos diagnósticos de EOP en relación a la población de referencia, entre 1994 y 2009, más marcado en el grupo de ≥ de 65 años. Asimismo, se ha constatado que los pacientes afectos de EOP presentan una disminución en la actividad biológica de la enfermedad, una menor extensión de la enfermedad y una mayor edad de presentación al diagnóstico, en función del año de nacimiento y año del diagnóstico. En contraposición, se ha observado mayor severidad en el momento del diagnóstico en los pacientes con edades al diagnóstico de <45 años y ≥75 años. Se han identificado 5 factores independientes de mal pronóstico al diagnóstico, que van a favorecer peores desenlaces. Por lo que podemos concluir, que en el momento de diagnóstico de EOP, la expresión de la enfermedad es menos severa y acontece de forma más tardía. Los resultados del estudio molecular destacan la asociación significativa entre los SNPs rs3018362 y rs1805034 del gen TNFRSF11A y rs11573871 del gen TNFRSF11B con el incremento de riesgo a desarrollar EOP así como la influencia en su fenotipo. Asimismo se observó que la presencia del alelo T en el polimorfismo rs6567274 del gen TNFRSF11A se asoció con una disminución de riesgo a desarrollar la EOP, así como a un fenotipo más leve. En el estudio molecular del gen SQSTM1 se identificaron seis variantes genéticas "missense" de nueva descripción, asociadas todas ellas a una mayor susceptibilidad en el desarrollo de la EOP.
Paget’s Disease of Bone (PDB) is characterized by a chronic and focal disorder of bone remodeling that leads to the appearance of complications as bone deformities, osteoarthritis and fractures. The PDB presents a great variability in its distribution depending on the age, gender, ethnics and geographic area. Recent studies have described secular changes in the prevalence, incidence and severity at diagnosis of PDB, showing a decline in the last decades. PDB is currently considered a multifactorial disease involving environmental and genetic factors. The gene which has shown higher susceptibility is the Sequestosome-1 (SQSTM1), the mutations described in it would not be able to explain completely the PDB pathogenesis. Nowadays, there are few studies on genetic variations in the TNFRSF11B and TNFRSF11A genes associated with classic PDB, as well as the existence of genetic interactions between both genes and the SQSMT1 gene, leading to an increased risk of PDB or even influencing the phenotype. To investigate the pattern of clinical-epidemiological and genetic behavior of the PDB in our low prevalence population, we propose the following objectives. The objectives were focused on evaluating changes in the evolution of the percentage of new PDB diagnoses during the period 1970-2009 and to describing in those patients differences in terms of severity at diagnosis. As well as to analyze the importance of molecular alterations in the SQSTM1 gene and the presence of allelic variations in the TNFRSF11B and TNFRSF11A genes, both in the susceptibility for the development of PDB and its influence on the phenotype. Patients and Methods: Descriptive, ambispective observational study of patients from Hospital del Mar-Parc de Salut Mar (Barcelona), a low prevalence area. 393 patients, diagnosed between 1970 and 2009, were included. Based on the molecular study, the genotyping of the 21 polymorphic variants was carried out for the study of the TNFRSF11B and TNFRSF11A genes, as well as the sequencing of the SQSTM1 gene in a population of 200 PDB affected patients and 200 hypernormal controls. Results: The study observed a progressive decrease in the percentage of new PDB diagnoses in relation to the reference population, between 1994 and 2009, more marked in the group ≥65 years old group. Thereby, it has been confirmed that the PDB-affected patients show a decrease in the biological activity of the disease, a lower extension of the disease, and a higher age of presentation at diagnosis, depending on the year of birth and the year of diagnosis. In contrast, it has been observed higher severity at diagnosis in patients with ages at diagnosis <45 years and ≥75 years. Five independent factors of poor prognosis at diagnosis have been identified, which will favor worse outcomes. We can conclude, that at the time of diagnosis of PDB, the expression of the disease is less severe and occurs later. The results of the molecular study highlight the significant association between SNPs rs3018362 and rs1805034 of the TNFRSF11A gene and rs11573871 of the TNFRSF11B gene with the increased risk of developing PDB as well as the influence on its phenotype. Thereby, it was observed that the presence of the T allele in the polymorphism rs6567274 of the TNFRSF11A gene was associated with a decreased risk of developing PDB, as well as a milder phenotype. In the molecular study of the SQSTM1 gene, six newly described “missense” genetic variants were identified, all associated with greater susceptibility in the development of PDB.
Universitat Autònoma de Barcelona. Programa de Doctorat en Medicina
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McManus, Stephen. „Regulation of osteoclast activation and autophagy through altered protein kinase pathways in Paget's disease of bone“. Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8960.

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Résumé : La maladie osseuse de Paget (MP) est un désordre squelettique caractérisé par une augmentation focale et désorganisée du remodelage osseux. Les ostéoclastes (OCs) de MP sont plus larges, actifs et nombreux, en plus d’être résistants à l’apoptose. Même si la cause précise de la MP demeure inconnue, des mutations du gène SQSTM1, codant pour la protéine p62, ont été décrites dans une proportion importante de patients avec MP. Parmi ces mutations, la substitution P392L est la plus fréquente, et la surexpression de p62P392L dans les OCs génère un phénotype pagétique partiel. La protéine p62 est impliquée dans de multiples processus, allant du contrôle de la signalisation NF-κB à l’autophagie. Dans les OCs humains, un complexe multiprotéique composé de p62 et des kinases PKCζ et PDK1 est formé en réponse à une stimulation par Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL), principale cytokine impliquée dans la formation et l'activation des OCs. Nous avons démontré que PKCζ est impliquée dans l’activation de NF-κB induite par RANKL dans les OCs, et dans son activation constitutive en présence de p62P392L. Nous avons également observé une augmentation de phosphorylation de Ser536 de p65 par PKCζ, qui est indépendante d’IκB et qui pourrait représenter une voie alternative d'activation de NF-κB en présence de la mutation de p62. Nous avons démontré que les niveaux de phosphorylation des régulateurs de survie ERK et Akt sont augmentés dans les OCs MP, et réduits suite à l'inhibition de PDK1. La phosphorylation des substrats de mTOR, 4EBP1 et la protéine régulatrice Raptor, a été évaluée, et une augmentation des deux a été observée dans les OCs pagétiques, et est régulée par l'inhibition de PDK1. Également, l'augmentation des niveaux de base de LC3II (associée aux structures autophagiques) observée dans les OCs pagétiques a été associée à un défaut de dégradation des autophagosomes, indépendante de la mutation p62P392L. Il existe aussi une réduction de sensibilité à l’induction de l'autophagie dépendante de PDK1. De plus, l’inhibition de PDK1 induit l’apoptose autant dans les OCs contrôles que pagétiques, et mène à une réduction significative de la résorption osseuse. La signalisation PDK1/Akt pourrait donc représenter un point de contrôle important dans l’activation des OCs pagétiques. Ces résultats démontrent l’importance de plusieurs kinases associées à p62 dans la sur-activation des OCs pagétiques, dont la signalisation converge vers une augmentation de leur survie et de leur fonction de résorption, et affecte également le processus autophagique.
Abstract : Paget’s disease of bone (PDB) is a skeletal disorder characterized by focal and disorganized increases in bone turnover. In PDB, osteoclasts are larger, more active, more numerous, and resistant to apoptotic stimuli. While no single root cause has been identified, mutations to the gene encoding the p62 protein, SQSTM1, have been described in a significant population of patients with PDB. Among these mutations, the P392L substitution is the most prevalent, and overexpression of p62P392L in osteoclasts generates at least a partial pagetic phenotype in vitro. Normally this protein mediates a number of cell functions, from control of NF-κB signaling to autophagy. In human osteoclasts, a multiprotein complex containing p62 and protein kinases PKCζ and PDK1 (the principal kinase of Akt), form in response to stimulation by receptor activator of nuclear factor kappa-B ligand (RANKL), the principal osteoclastogenic-signaling cytokine. We found that PKCζ is involved in RANKL-induced activation of NF-κB, and that it contributed to a basal activation of NF-κB observed in p62P392L mutants. This may be regulated in part by a PKCζ dependent increase in p65 phosphorylation at Ser536 which we characterized, independent of IκB. This could represent one alternative pathway by which mutant p62 leads to increased NF-κB activation. We observed increased basal phosphorylation of survival regulators ERK and Akt in PDB that was reduced upon PDK1 inhibition. The activity of 4EBP1 and Raptor, associated with mTOR activity, were also altered in pagetic osteoclasts and regulated by PDK1 inhibition. We then identified autophagic defects common to pagetic osteoclasts; with higher basal levels of LC3II (associated with autophagic structures), regardless of p62 mutation, and reduced sensitivity to autophagy induction in PDB. These results suggest an accumulation of non-degradative autophagosomes. Inhibition of PDK1 not only induced apoptosis in PDB and controls, but significantly reduced resorption in PDB, and with regards to autophagy, PDK1 inhibition was more potent in PDB than in controls. Therefore PDK1/Akt signaling represents an important checkpoint to PDB osteoclast activation. In sum, these results demonstrate the importance of several p62-associated kinases in the over-activation of pagetic osteoclasts, through increased survival and altered signaling. As p62 mutations alone do not account for most cases of PDB, the characterization of these pathways may identify a common factor linking pagetic osteoclasts. Therefore these studies represent a novel approach to osteoclast apoptosis, activation, and autophagy associated with PDB.
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Bounahai, Najib. „Moors in Elizabethan/Jacobean entertainments : race, performance and politics /“. Thesis, Connect to Dissertations & Theses @ Tufts University, 2001.

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Thesis (Ph.D.)--Tufts University, 2001.
Adviser: Barbara Freedman. Submitted to the Dept. of Drama. Includes bibliographical references (leaves 191-207). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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Yoshino, Ayako. „The Edwardian historical pageant“. Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614849.

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Nazari, Shekeba. „Maladie de Paget : résistance à l'apoptose et défaut de l'autophagie“. Mémoire, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11869.

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La maladie de Paget est une ostéopathie caractérisée par une augmentation multifocale du remodelage osseux, qui débute par un front de résorption osseuse, suivi d'une formation osseuse excessive, avec un remodelage anarchique et intense. Les ostéoclastes "OCs" impliqués dans la phase initiale sont les cellules responsables dans l'initiation du processus pagétique. Les OCs pagétiques sont caractérisés par une résistance à l'apoptose, et des anomalies du processus de l'autophagie "en particulier défaut d'induction"; afin de voir si ces deux caractéristiques étaient liées, nous avons émis l'hypothèse d’un rôle des complexes Bcl2-Beclin1. Beclin-1 est une protéine inductrice de l'autophagie qui peut lier les protéines anti-apoptotiques de la famille Bcl-2; Bcl-2 inhibe alors Beclin-1 "et donc l'induction de l'autophagie" en conservant ses fonctions anti-apoptotiques. Dans le but d'étudier l'impact de l'expression de Bcl2 sur l’autophagie dans les OCs humains, nous avons utilisé un modèle de différenciation in vitro à partir de monocytes dérivés de sang de cordon ombilical, cultivés en présence de RANKL et MCSF pendant 21 jours. Ces conditions permettent d'obtenir des cellules multinucléées au phénotype ostéoclastique. Pour augmenter l’expression de Bcl-2 dans les OCs et analyser son impact sur l’autophagie par interaction avec Beclin-1, les cultures ont été stimulées par TNFα ou RANKL dans le but d'induire une activation de NF-κB. L'expression de Beclin1 et Bcl2 a été confirmée par immunobuvardage dans les OCs. L’autophagie était induite dans les cultures réalisées en conditions stringentes "milieu pauvre en nutriments", sans variation de l'expression de Bcl2 ou Beclin 1 selon les conditions, et sans impact de TNFa ou RANKL. TNFa stimulait de manière significative l'activation de NF-kB dans les cellules HEK mais pas dans les OCs. Toutefois, et quelque soit les conditions, les immunoprécipitations ne permettaient pas de retrouver d'association entre Beclin1 et Bcl2. En revanche, le partenaire d'interaction classique de Beclin1, PI3K type III, était associé à Beclin1. En conclusion, notre travail n'a pas permis d'étudier la formation des complexes Beclin1/Bcl2 et les relations entre apoptose et autophagie, en partie du fait de la complexité du modèle "effets multiples de NF-kB et TNFa" ce qui n'exclut pas l'hypothèse initiale "à ré-évaluer par une méthodologie plus appropriée". En revanche les différentes techniques d'analyse sont maintenant au point pour la poursuite de l'étude.
Abstract : Paget's disease is an osteopathy characterized by a multifocal increase in bone remodeling, which begins with excessive bone resorption followed by increased bone formation. Osteoclasts "OCs" were incriminated in the initiation of the pagetic process. Pagetic OCs are characterized by a resistance to apoptosis, and abnormalities in the process of autophagy “in particular induction defect”. In order to define whether these two characteristics were linked, we hypothesized the role of Bcl2-Beclin1 complexes. Beclin-1 is an autophagy-inducing protein that can bind anti-apoptotic proteins of the Bcl-2 family; Bcl-2 then inhibits Beclin-1 "and thus the induction of autophagy" while retaining its anti-apoptotic functions. To study the impact of Bcl2 expression on autophagy in human OCs, we used an in vitro differentiation model that uses monocytes, which are derived from umbilical cord blood and grown in the presence of RANKL and MCSF for 21 days. These conditions make it possible to obtain multinucleated cells with an osteoclastic phenotype. To increase the expression of Bcl-2 in OCs and analyze its impact on autophagy due to its interaction with Beclin-1, cultures were stimulated with TNFα or RANKL in order to induce NF-κB activation. The expression of Beclin1 and Bcl2 was confirmed by immunoblotting of Ocs cell lysates. Autophagy was induced in cultures carried out under stringent conditions "nutriment-deprived mediun", but we did not observe any variation in the expression of Bcl2 or Beclin 1 according to the culture conditions or TNFα or RANKL stimulation. TNFα significantly stimulated the activation of NF-κB in HEK cells but not in OCs. However, whatever the conditions, results from immunoprecipitaion experiments did not reveal any association between Beclin1 and Bcl2. On the other hand, the classic interaction partner of Beclin1, PI3K type III, was associated with Beclin1. In conclusion, our work did not allow us to demonstrate the formation of Beclin1 / Bcl2 complexes and the relationship between apoptosis and autophagy, partly because of the complexity of the model "multiple effects of NF-κB and TNFα". Our initial hypothesis should thereby be re-evaluated using a more appropriate methodology. On the other hand, the different techniques are now ready for further study.
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Beckham, Kathryn Ann. „'The Gate City' artistry and identity in an American historical pageant (Nebraska) /“. Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 14.18 Mb., 74 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1435838.

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Bücher zum Thema "Pagents"

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Thomas, Heywood. Thomas Heywood's pageants: A critical edition. New York: Garland Pub., 1986.

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Makartsoŭ, Mikola. Pa svi͡a︡tochnykh shli͡a︡khakh Belarusi: Rėz͡h︡ysi͡o︡rskii͡a︡ natatki. Minsk: Vyd-va "Chatyry chvėrtsi", 1999.

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Zelov, D. D. Ofit︠s︡ialʹnye svetskie prazdniki kak i︠a︡vlenie russkoĭ kulʹtury kont︠s︡a XVII-pervoĭ poloviny XVIII veka: Istorii︠a︡ triumfov i feĭerverkov ot Petra Velikogo do ego docheri Elizavety. Moskva: Ėditorial URSS, 2002.

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Luigi, Allegri, und Di Benedetto Renato, Hrsg. La Parma in festa: Spettacolarità e teatro nel Ducato di Parma nel Settecento. Modena, Italia: Mucchi, 1987.

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Wood, Stevens Thomas. Magna Carta: A pageant drama. Chicago: American Bar Association, 1994.

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Pretini, Giancarlo. La piazza delle meraviglie: Il teatro in strada italiano. Reana del Rojale (UD): Trapezio, 1999.

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Millones, Luis. El Inca por la coya: Historia de un drama popular en los Andes peruanos. Lima: Fundación Friedrich Ebert, 1988.

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Copyright Paperback Collection (Library of Congress), Hrsg. The Northeast girls. New York: Berkley Jam Books, 1998.

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Randolph, Sallie G. Putting on perfect proms, programs & pageants. New York: F. Watts, 1991.

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Yves, Pauwels, und Bibliothèque municipale Livrée Ceccano (Avignon, France), Hrsg. Les entrées solennelles à Avignon et à Carpentras, XVIe-XVIIIe siècles: 18 septembre-24 octobre 1997, Bibliothèque municipale, Avignon. [Paris]: Ministère [de la] culture [et de la] communication, Direction du livre et de la lecture, 1997.

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Buchteile zum Thema "Pagents"

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Tate, Shirley Anne. „Beauty pageants“. In From Post-Intersectionality to Black Decolonial Feminism, 121–53. London: Routledge, 2022. http://dx.doi.org/10.4324/b23223-5.

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Krasner, David. „African American Performance in the Harlem Renaissance“. In A Beautiful Pageant, 1–14. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_1.

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Krasner, David. „“What Constitutes a Race Drama and How May We Know It When We Find It?”: The Little Theatre Movement and the Black Public Sphere“. In A Beautiful Pageant, 207–38. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_10.

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Krasner, David. „Shuffle Along and the Quest for Nostalgia: Black Musicals of the 1920s“. In A Beautiful Pageant, 239–88. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_11.

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Krasner, David. „Conclusion: The end of “Butter Side Up”“. In A Beautiful Pageant, 289–92. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_12.

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Krasner, David. „Men in Black and White: Race and Masculinity in the Heavyweight Title Fight of 1910“. In A Beautiful Pageant, 17–54. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_2.

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Krasner, David. „Exoticism, Dance, and Racial Myths: Modern Dance and the Class Divide in the Choreography of Aida Overton Walker and Ethel Waters“. In A Beautiful Pageant, 55–80. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_3.

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Krasner, David. „“The Pageant Is the Thing”: Black Nationalism and The Star of Ethiopia“. In A Beautiful Pageant, 81–94. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_4.

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Krasner, David. „Walter Benjamin and the Lynching Play: Mourning and Allegory in Angelina Weld Grimké’s Rachel“. In A Beautiful Pageant, 97–111. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_5.

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Krasner, David. „Migration, Fragmentation, and Identity: Zora Neale Hurston’s Color Struck and the Geography of the Harlem Renaissance“. In A Beautiful Pageant, 113–30. New York: Palgrave Macmillan US, 2002. http://dx.doi.org/10.1007/978-1-137-06625-1_6.

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Konferenzberichte zum Thema "Pagents"

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Shrestha, Eliza, Rupinder Shekon, Shveta Giri und Sudhir Rawal. „Paget’s disease of the vulva in postmenopausal women: A case report“. In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685383.

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Vulvar Paget’s disease is an extremely rare neoplasm that accounts for less than 1% of vulvar malignancies. We present a case of a 66 year old woman, who had an ulcerated lesion involving the labia majora bilaterally; lymph nodes were not palpable in the inguinal region bilaterally. A biopsy of the Vulva showed Paget’s disease. She underwent radical Vulvectomy with Bilateral inguinal lymph node dissection. The specimens resected were reviewed with respect to involvement of the margins with Paget cells and the margin was negative. The patient remained disease free at 2 years follow up.
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Tensmeyer, Chris, Brian Davis, Curtis Wigington, Iain Lee und Bill Barrett. „PageNet“. In HIP2017: The 4th International Workshop on Historical Document Imaging and Processing. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3151509.3151522.

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Barros, Emanuelle de Lima, Andre Silva Machado, Josie Haydée Lima Ferreira Paranaguá, Débora Medeiros de Carvalho, Marcos Josué Rocha Cabral de Oliveira, Carlos Eduardo Moura de Lima und Sabas Carlos Vieira. „Mammary Paget’s disease: Clinical–epidemiological profile in a reference oncology clinic in the capital of Piauí“. In Brazilian Breast Cancer Symposium 2023. Mastology, 2023. http://dx.doi.org/10.29289/259453942023v33s1090.

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Objective: The objective of this study was to identify the clinical and epidemiological profile of patients diagnosed with breast Paget’s disease from December 2006 to January 2023 in a reference oncology clinic in the city of Teresina, PI, Brazil. Methodology: This is an observational, descriptive, quantitative, and retrospective study conducted by collecting the data from medical records. We analyzed 982 medical records of female patients with breast cancer. Variables such as age, personal and family history of cancer, presence of pathogenic variants in the panel tested, and pharmacological and surgical interventions were analyzed, tabulated, and analyzed descriptively in Microsoft Excel. The study included all the medical records of patients seen in this period, excluding those who did not have breast cancer or whose records did not provide sufficient information. The study was approved by the Research Ethics Committee, opinion number 3015472.0.0000.05209. Results: Of the patients diagnosed with breast cancer, those with the mammary form of Paget’s disease represented 0.3% of the total. In two of the three cases, Paget’s disease was associated with invasive ductal carcinoma and there was one case of Paget’s tumor. The mean age was 57 years, and two cases were in postmenopausal women. Among the clinical characteristics, the degree of differentiation most commonly found was G3 (66.7%), followed by G2 (33.3%). All patients had RE+/RP+ pattern. Conclusion: In this study, the cumulative incidence of Paget’s tumor of the breast in women diagnosed with breast cancer in the study population from December 2006 to January 2023 was 0.3%, and of this total, 66.7% were associated with invasive ductal carcinoma.
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Wentorf, Deb. „Printed pages vs. web pages“. In the 29th annual ACM SIGUCCS conference. New York, New York, USA: ACM Press, 2001. http://dx.doi.org/10.1145/500956.501005.

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„Pages“. In 2010 68th Annual Device Research Conference (DRC). IEEE, 2010. http://dx.doi.org/10.1109/drc.2010.5551914.

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Belluco, Rosana Zabulon Feijó, Flávio Lúcio Vasconcelos, Paulo Eduardo Silva Belluco, Júllia Eduarda Feijó Belluco und Carmelia Matos Santiago Reis. „NIPPLE MINIMUM PAGET DISEASE: A CASE REPORT“. In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1059.

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Paget’s disease (PD) of the nipple is a rare cancer that affects the nipple and areola and accounts for between 0.4% and 5% of breast cancers. It was first described in 1877 by the English physician Sir James Paget. It affects women between 60 and 70 years of age and very rarely affects men. In PD, the skin on the nipple and areola becomes thicker. Clinical presentations are usually erythema, desquamation, or eczematous changes in the nipple, features that can progressively progress to erosion, overt destruction, and ulceration of the papilla. Bloody papillary discharge, itching, nipple retraction, and/or a palpable mass may be associated. Cancer cells, called Paget cells, are malignant, large, with clear, abundant cytoplasm and nuclei with prominent nucleoli. Like glandular cells, they appear either as isolated cell in the epidermal tissue or as groups of cells. Most women diagnosed with PD also have ductal adenocarcinoma, either in situ or invasive. The prevalence is 67–100% of cases, which gives a worse prognosis to the patient. Patients with Paget-associated invasive breast disease have lower hormone receptor expression, greater lymph node involvement, and higher human epidermal growth factor receptor type 2 (HER2) expression. An 82-year-old woman sought the mastology outpatient clinic for a follow-up of carcinoma in situ in the right breast 2 years ago, having been submitted to quadrantectomy and hormone therapy with tamoxifen, with no signs of recurrence. She complained of an exudative pruritic lesion on the left nipple that had started 6 months ago. She reported that the lesion started with itching and burning, associated with a spontaneous discharge of serous secretion from the itchy surface of the breast, which improved with the use of “talcum powder.” On physical examination, the presence of a discrete reddened area with a diameter of 3 mm, eczematous, with bloody areas interspersed with serous secretion was observed on the left nipple. Areola lesions and palpable nodules in the left breast were absent. She underwent mammography, which showed symmetrical breasts with fat-replaced parenchyma, absence of nodules, presence of isolated calcifications, and grouping in the superior lateral region of the left breast, categorized as BIRADS II. On ultrasound, a nodule with angled edges, measuring 5×4 mm in the superomedial quadrant of the left breast, which showed nodular enhancement and persistent kinetic curve on magnetic resonance imaging of the breasts. The histopathological study diagnosed moderately differentiated left breast ductal carcinoma, associated with a high-grade solid intraductal carcinoma and PD of the nipple, without the involvement of the areola. Immunohistochemistry revealed the absence of estrogen and progesterone hormone receptors and HER-2 overexpression in both histological types. She underwent mastectomy with sentinel lymph node biopsy that was free of neoplasia. Oncological follow-up with no signs of recurrence. PD, if left untreated, extends to the areola and other regions of the breast. Therefore, clinical suspicion from the first physical examination allows an early diagnosis of extreme importance, which improves the prognosis and allows less aggressive treatments.
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Alzahr, A., M. Mansour und B. Knof. „Paget's disease in temporal bone“. In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640234.

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Ben Chehida, R., S. Ben Jemaa, Z. Gassara, A. Feki, M. Ezzeddine, R. Akrout, M. H. Kallel, H. Fourati und S. Baklouti. „AB0281 PAGET’S DISEASE: EPIDEMIOLOGICAL PROFILE“. In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.4033.

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„TERN/AusCover - Remote sensing data management for terrestrial ecosystem research“. In 19th International Congress on Modelling and Simulation. Modelling and Simulation Society of Australia and New Zealand (MSSANZ), Inc., 2011. http://dx.doi.org/10.36334/modsim.2011.h4.paget.

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„Title pages“. In 2009 International Conference on Biomedical and Pharmaceutical Engineering (ICBPE 2009). IEEE, 2009. http://dx.doi.org/10.1109/icbpe.2009.5384061.

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Berichte der Organisationen zum Thema "Pagents"

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Postel, J., und C. Anderson. White Pages Meeting Report. RFC Editor, Februar 1994. http://dx.doi.org/10.17487/rfc1588.

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Reddy, Sakamuri. Osteoclast Inhibitory Peptide-1 Therapy for Paget's Disease. Fort Belvoir, VA: Defense Technical Information Center, August 2010. http://dx.doi.org/10.21236/ada539193.

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Reddy, Sakamuri V. Osteoclast Inhibitory Peptide-1 Therapy for Paget's Disease. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada567774.

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Reddy, Sakamuri. Osteoclast Inhibitory Peptide-1 Therapy for Paget's Disease. Fort Belvoir, VA: Defense Technical Information Center, August 2011. http://dx.doi.org/10.21236/ada553287.

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Hansen, Marc. The Nature of Expansion of Paget's Disease of Bone. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada586286.

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Hansen, Marc F. Understanding the Delay in Onset of Paget's Disease of Bone. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada613442.

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Hansen, Marc. On the Nature of Expansion of Paget's Disease of Bone. Fort Belvoir, VA: Defense Technical Information Center, Oktober 2012. http://dx.doi.org/10.21236/ada573353.

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Resnik, P. Evaluating Multilingual Gisting of Web Pages. Fort Belvoir, VA: Defense Technical Information Center, März 1997. http://dx.doi.org/10.21236/ada458592.

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Alvestrand, H., und P. Jurg. Deployment of the Internet White Pages Service. RFC Editor, September 1997. http://dx.doi.org/10.17487/rfc2148.

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Hutchins, Thomas. PR744-22113-Z01 Hydrogen Natural Gas Blends in Existing Natural Gas Systems. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), November 2022. http://dx.doi.org/10.55274/r0012245.

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A series of short documents summarizing the issues and facts as currently known related to the transportation of hydrogen via pipeline. There are seven papers in this bundle: - PR744-22113-E01A Hydrogen Natural Gas Blending and Separation, 2 pages - PR744-22113-E01B Hydrogen Natural Gas Blends and Compressor Stations, 2 pages - PR744-22113-E01C Hydrogen Natural Gas Blends and End User Equipment, 1 page - PR744-22113-E01D Hydrogen Natural Gas Blend Measurement and Gas Quality, 2 pages - PR744-22113-E01E Hydrogen Natural Gas Blends and Pipeline Integrity, 2 pages - PR744-22113-E01F Hydrogen Natural Gas Blending and Safety, Inspection, and Maintenance, 3 pages - PR744-22113-E01G Hydrogen Natural Gas Blends in Existing Natural Gas Pipelines, 3 pages - PR744-22113-E01H Storage of Hydrogen Natural Gas Blends, 2 pages
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