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Bartolomé, de la Peña Rafael. „Evolución tectónica del margen continental oeste de México: Fosa Mesoamericana y Golfo de California (CORTES-P96)“. Doctoral thesis, Universitat de Barcelona, 2002. http://hdl.handle.net/10803/1927.
Der volle Inhalt der QuelleEl oeste mexicano comprende en el norte un margen transformante formado por un conjunto de zonas de expansión. Este enjambre de fallas de salto en dirección supone el límite de las placas Pacífico-Norteamericana entre los 32º N y los 23º N. Entre 23º N y 19º N y con una velocidad relativa de convergencia de 2.0 cm/año (Pardo et al., 1995) se sitúa la dorsal Pacífico-Rivera (Pacific Rivera Rise, PRR), que confina el límite entre las placas de Rivera y Pacífico. Entorno a los 21º N se encuentra el extremo septentrional de la fosa mesoamericana (MAT), donde se alcanzan profundidades de 6000 m y la zona de colisión y subducción de la microplaca de Rivera y la placa de Cocos respectivamente.
En la campaña CORTES-P96 se adquirieron nuevos datos de sísmica multicanal (MCS) y de gran ángulo, gravimetría, batimetría, sonografías y magnetismo que incluyen las zonas de contacto entre el Bloque de Jalisco y la zona de fractura Rivera, hasta la terminación norte de la zona de fractura de Tamayo en el extremo sur de Baja California.
La integración de estos datos geofísicos nos ha permitido deducir la estructura litosférica, mejorando la comprensión de la dinámica de la subducción en la MAT y definiendo las características principales de la corteza. Además, se ha condicionado un modelo geodinámico que ajusta los valores gravimétricos de la zona y la localización temporal de algunos eventos gracias al estudio de las anomalías magnéticas de expansión oceánica.
El análisis del primer segundo de los perfiles de MCS ha permitido obtener imágenes del BSR (Bottom Simulating Reflector), un reflector anómalo que está asociado a un cambio de polaridad en la señal sísmica originado por la presencia de hidratos de gas (de composición mayoritariamente de metano). Los datos MCS nos han permitido cartografiar la zona que contiene BSR. Además, el análisis cuantitativo de la señal sísmica ha permitido la obtención del coeficiente de reflexión, la estructura de la velocidad y el gradiente térmico.
El estudio conjunto de los datos MCS y de gran ángulo nos proporciona la caracterización de la estructura crustal profunda. Se ha identificado un prisma de acreción de 20 km de extensión con una velocidad para las ondas P de 3.5 km/s. La subducción se observa alrededor de los 6s (dtr), en todos los perfiles multicanal. La placa que subduce muestra un ángulo variable de sur a norte, mostrando promedio de 9º. La placa oceánica de Rivera tiene un grosor máximo de 9 km. La velocidad del manto superior bajo la placa en subducción es de 7.8 km/s.
Al noroeste de la placa de Rivera, hacia las islas Tres Marías, la interpretación conjunta de datos incluyendo sonografías, anomalías gravimétricas y distribución de velocidades parece indicar que el límite continental-oceánico está más cerca de Baja California de lo que previamente se pensaba, mostrando una asimetría clara respecto del EPR y mostrando una extensa zona de transición, que se inicia al sureste del MMR y continua hacia el oeste del margen de México. Los datos magnéticos nos permiten controlar la edad del basamento oceánico. La anomalía magnética más antigua detectada ha sido la 2A (3.5 Ma). El grosor medio de la corteza oceánica alrededor del EPR es de 6 km, con un rápido crecimiento hacia el extremo sur de Baja California. Hacia el sureste el engrosamiento es más gradual alcanzando grosores entre 8-10 km bajo el MMR, y 15 km en el final del margen.
During the CORTES-P96 project a new multichannel (MCS) and wide-angle seismic, potential fields (gravity and magnetics), bathymetry, and backscatter data were achieved along the Jalisco Block and the RFz (Pto. Vallarta) until the northern termination of the Tamayo Fracture zone in the southern tip of Baja California.
The integration of bathymetric, MCS and wide-angle seismic, together with gravity and seismicity data allows us to determine the west Mexican lithospheric structure in a pseudo 3D image and the 2D equivalents, improving the geodynamic comprehension of the subducting plates in the MAT, and defining the main crustal characteristics of the collision zone.
The analysis of 1s (twtt) in the MCS profiles allows us to clearly imaged the BSR. From the seismic signal analysis we work out the reflection coefficient, the velocity profile and the thermal gradient.
MCS and wide-angle data characterize the deep crustal structure. We clearly imaged an accretionary prism of 20 km of extension with P-wave velocity of around 3.5 km/s. The overriding oceanic plate subducts with a variable angle from south to north, showing a mean deep angle of 9º +/-2º. This oceanic crust (Rivera plate) has a mean thickness of 4 km, and is located beneath a low velocity layer of 3.3-3.9 km/s, which seems to be a typical feature of the MAT. In most of the MCS profiles the subduction plane is observed around 6 s (twtt), and a strong reflection which we interpret as a Moho discontinuity is detected at 8s.
Northwest of Rivera Plate, close to Tres Marias Islands, a join interpretation of the various dataset indicate that the continental-oceanic boundary is closer to the Baja California that previously was thought, showing an EPR asymmetry that indicates a transition zone starting southeast of Maria Magdalena Rise and extends to the west margin of Mexico. The magnetic data have been used to control the age of the oceanic basement. The average thickness of the oceanic crust around the EPR is 6 km. Towards the southeast the thickness gradually reaches values between 8-10 km beneath the MMR, and 15 km at the end of the margin.
Davies, Michael I. „High temperature nanoindentation characterisation of P91 and P92 steel“. Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13233/.
Der volle Inhalt der QuelleKander, Jan. „Kinetika šíření únavových trhlin v ocelích P91 a P92“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-442745.
Der volle Inhalt der QuelleSaber, Mohammed. „Experimental and finite element studies of creep and creep crack growth in P91 and P92 weldments“. Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12197/.
Der volle Inhalt der QuelleFiegenbaum, Fernanda. „Estudo da compatibilização das blendas PP/PA6 e PA6/EPR“. reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/14860.
Der volle Inhalt der QuelleIn this work an evaluation of the compatibilization of the Polypropylene (PP)/Polyamide-6 (PA6) blends and Polyamide-6/Ethylene-Propylene Rubber (EPR) blends was carried out. A funcionalized PP and a funcionalized EPR were used as compatibilizer agent in the first and second systems, respectively. The binary blends PP/PA6 were prepared in the proportions 70/30 and the ternary mixtures PP/PP-MA/PA6 in the proportions 65/5/30, both in Haake Rheomex PTW Extruder and Haake Rheomex CTW100p Extruder. The binary blend PA6/EPR was prepared in the proportion 70/30 and the ternary blend PA6/EPR-MA/EPR in the proportion 70/5/25, using a Haake Polylab Rheometer with internal mixer module. The compatibilizer agent EPR-MA was prepared in a Haake Rheomex PTW Extruder functionalized with 1 wt % of maleic anhydride (MA) as grafting agent and 0.1% of Luperox as initiator. The obtained blends were characterized for Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), Dynamic Mechanical Thermal Analysis (DMTA), roational rheometry and mechanical properties measurements. When necessary the significance of the differences among samples was statically analyzed using a t test. The results showed that the addition of the compatibilizer agents PP-MA and EPRMA provokes an alteration in the morphology of the blends, increasing miscibility and reducing the size of the dispersed phase particles. Besides, the dynamic-mechanical thermal and rheological analyses indicate interaction between the phases caused by the compatibilization. The mechanical analysis of the blends PP/PA6 showed a better performance of the ternary blends in comparison to the binary blends.
Guckelberg, Bruce William. „Believers' demonization, a doctrinal evaluation“. Theological Research Exchange Network (TREN) Access this title online, 2005. http://www.tren.com/search.cfm?p096-0003.
Der volle Inhalt der QuelleLemke, Lenard C. „Understanding the motivation of church planters in Crimea, Ukraine“. Theological Research Exchange Network (TREN) Access this title online, 2005. http://www.tren.com/search.cfm?p096-0004.
Der volle Inhalt der QuelleRoeder, Jerusa. „Blendas PP/PA6 compatibilizadas“. Florianópolis, SC, 2001. http://repositorio.ufsc.br/xmlui/handle/123456789/81726.
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Baird, David. „Zeitgeist incarnate : a theological interpretation of postapocalyptic zombie fiction“. Thesis, University of St Andrews, 2019. http://hdl.handle.net/10023/16978.
Der volle Inhalt der QuelleDuchovnay, Alan. „Comparative Electrochemistry, Electronic Absorption Spectroscopy and Spectroelectrochemistry of the Monometallic Ruthenium Polypyridyl Complexes, [Ru(Bpy)(Dpb)2](Pf6)2, [Ru(Bpy)2(Dpb)](Pf6)2, [Ru(Bpy)2(Dpq)](Pf6)2, [Ru(Bpy)(Dpq)2](Pf6)2“. Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/31917.
Der volle Inhalt der QuelleMaster of Science
Briggs, Louise Clare. „Biochemical studies of P97 AAA ATPase“. Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/11495.
Der volle Inhalt der QuelleKohlar, Stefanie. „Gefüge und Eigenschaften des warmfesten Chromstahls P91“. Helmholtz-Zentrum Dresden - Rossendorf, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-229778.
Der volle Inhalt der QuelleFasahat, F., R. Dastjerdi und M. R. M. Mojtahedi. „Thermophysiological Comfort by PA6/TiO2 Nanocomposite Yarns“. Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35603.
Der volle Inhalt der QuelleYau, Alvin. „Mechanical characteristics of PA6-monmorillonite [i.e. montmorillonite] nanocomposites“. access abstract and table of contents access full-text, 2004. http://libweb.cityu.edu.hk/cgi-bin/ezdb/dissert.pl?msc-ap-b21175226a.pdf.
Der volle Inhalt der QuelleAt head of title: City University of Hong Kong, Department of Physics and Materials Science, Master of Science in materials engineering & nanotechnology dissertation. Title from title screen (viewed on Sept. 4, 2006) Includes bibliographical references.
Heubes, Simone. „The AAA-ATPase p97 in mitosis and fertilization“. Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-76361.
Der volle Inhalt der QuelleKloppsteck, Jan Patrik. „Structural and functional studies of p97 adaptor interactions“. Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539279.
Der volle Inhalt der QuelleLaw, Bic-fai Fian, und 羅璧輝. „The role of p16 gene in oesophageal carcinoma“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970126.
Der volle Inhalt der QuellePeravali, Sudhakar. „Anisotropic creep and damage behaviour of P91 weldments“. Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444652.
Der volle Inhalt der QuelleSailan, Ahmad Tarmidi. „HPV and p16 in head and neck cancer“. Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/b5f54490-758e-4aaa-9cc4-3de043c4c9ce.
Der volle Inhalt der QuelleQuesnel, Bruno. „Gene p16 ink4a , p15 ink4b, et hemopathies malignes“. Lille 2, 1997. http://www.theses.fr/1997LIL2T009.
Der volle Inhalt der QuelleFasahat, F., R. Dastjerdi und M. R. M. Dastjerdi. „Abrasion Resistance of Ag/SiO2/PA6 Nanocomposite Fabrics“. Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35638.
Der volle Inhalt der QuelleUmar, Muneer. „Processing, structure and properties of PA6/carbon composites“. Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/processing-structure-and-properties-of-pa6carbon-composites(8573d69a-e4f1-4ea9-99ef-edabc141da45).html.
Der volle Inhalt der QuelleLaw, Bic-fai Fian. „The role of p16 gene in oesophageal carcinoma“. Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2342736X.
Der volle Inhalt der QuelleBeauparlant, Stephen Lewis. „Functional characterization of the p97 adaptor protein UBXD1“. Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213118.
Der volle Inhalt der QuellePh.D.
p97 is a member of the AAA family of proteins (ATPase Associated with various cellular Activities). It is a highly conserved and abundant protein and functions in numerous ubiquitin-mediated processes including ERAD. Endoplasmic Reticulum Associated Degradation is the process by which misfolded/ubiquitinated proteins translocate out of the ER and migrate to the proteasome for degradation. p97 maintains substrate misfolding and mediates its exit from the ER and trafficking to the 26S proteasome. It also plays important roles in protein trafficking, the cell-cycle, apoptosis and homeotypic Golgi Apparatus and Endoplasmic Reticulum membrane fusion after mitosis. In addition, p97 plays a role in the aggresome-autophagy degradation pathway, which handles the ubiquitin-mediated destruction of aggregate-prone, misfolded, cytosolic proteins. p97 mutation is the causative alteration in the disorder, IBMPFD, which is marked by defects in autophagy. This broad diversity of function is mediated through p97's interaction with a large group of adaptor proteins. Many of these adaptors harbor both p97 interaction motifs and ubiquitin association domains. However, more than half of known p97 adaptors do not. Their function is largely unknown. UBXD1 is one known adaptor for p97 that does not have a ubiquitin association domain (UBA), and has been shown to have decreased interaction with IBMPFD mutant p97R155H and p97A232E. Recently, it has been suggested to perform a role in protein trafficking, specifically in monoubiquitinated caveolin-1 internalization and trafficking to the endosome. A novel high abundance UBXD1 interacting partner has been identified via solution-based mass spectrometric analyses. ERGIC-53, the namesake of the ER-Golgi Intermediate Compartment, has been shown to be involved in bi-directional trafficking between the ER and Golgi. The association between UBXD1 and ERGIC-53 is unique among UBX family members. Deletional analysis has shown that unlike p97, the ERGIC-53-UBXD1 interaction takes place in the extreme amino terminus of UBXD1, (within the first 10 amino acids) which is predicted by computer modeling to form a hydrophobic binding pocket. Further site-directed mutagenesis work has clearly shown four amino acids (3 highly hydrophobic) are crucial for maintaining this interaction. They have been modeled to form a conserved alpha-helix. ßCOPI, a primary member of the COPI coatomer complex which is involved in protectively coating ERGIC-53 positive vesicles, is also thought to be involved with the ERGIC-53-UBXD1-p97 pathway. ßCOPI has been identified as a UBXD1-independent interactor with p97. Modest UBXD1 over- expression using a ponasterone inducible system has shown that UBXD1 modulates ERGIC-53 localization. Additionally, a functional link between UBXD1, p97 and ERGIC-53 in autophagy has been discovered through the use of a highly efficient, miR30-based, inducible knockdown system. Upon individual knockdown of UBXD1, p97 and ERGIC-53, autophagic markers p62 and LC3-II accumulate at relatively high levels in normal culture conditions, strongly suggesting a role in mediating basal autophagy. However, when placed under starvation conditions, autophagy progresses and p62 is degraded. It is speculated from these studies that a p97/UBXD1 complex plays a role in regulating the trafficking of ERGIC-53 positive vesicles and this activity plays an important role in autophagy.
Temple University--Theses
Saker, Mirna. „Identification de l'ostéopontine comme facteur libéré par les cellules vasculaires sénescentes et son implication dans l'hypertension pulmonaire“. Thesis, Paris Est, 2015. http://www.theses.fr/2015PESC0047.
Der volle Inhalt der QuelleRationale: Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute tothe pathogenesis of pulmonary hypertension (PH) by producing secreted factors.Objective: To explore the role in PH of extracellular matrix proteins released by senescentPA-SMCsMethods and results: Microarray analysis of human PA-SMCs undergoing replicativesenescence revealed osteopontin upregulation, which mediated the stimulatory effect ofsenescent PA-SMC media and matrix on PA-SMC growth and migration. Osteopontin wasupregulated in lungs from patients with COPD or idiopathic pulmonary arterial hypertension(PAH). Prominent osteopontin immunostaining was noted in PA-SMCs that also stained forp16 at sites of vascular hypertrophy, and lung osteopontin levels correlated closely with age.Compared to younger mice, 1-year-old mice displayed higher lung osteopontin levels, rightventricular systolic pressure (RVSP), pulmonary vessel muscularization, and numbers ofPA-SMCs stained for p16 or p21 and also for osteopontin. No such changes with age wereobserved in osteopontin-/- mice, which developed attenuated PH during hypoxia. Comparedto cultured PA-SMCs from young mice, PA-SMCs from 1-year-old mice grew faster; asimilar fast growth rate was seen with PA-SMCs from young mice stimulated by matrix ormedia from old mice. Differences between old/young mouse PA-SMC growth rates weresuppressed by anti-osteopontin antibodies. PA-SMCs from osteopontin-/- mice grew moreslowly than did wild-type PA-SMCs; they were stimulated by wild-type PA-SMCs mediaand matrix, and this effect was stronger with PA-SMCs from older vs. younger mice.Conclusion: Osteopontin is a key mediator released by senescent PA-SMCs andcontributing to PH progression
Hayama, Fábia Hiromi. „"Estudo da expressão da p16 em casos de líquen plano bucal"“. Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-28082006-181239/.
Der volle Inhalt der QuelleWe realized immunohistochemical procedures with p16 and Ki-67 in lesions of oral lichen planus to verify the presence and kind of its immunoexpression amog the two groups of patients, asymptomatic and symptomatic, correlating the clinical and histopathological diagnosis with the immunohistochemical data in order to verify if oral lichen planus can be considered a lesion with risk of malignant transformation. MATERIAL AND METHOD: nine asymptomatic patients and 12 symptomatic of oral lichen planus. Five cases of inflammattory fibrous hyperplasia were included as control group. For immunohistochemical studies we used p16 (predilutedBioSB/USA) and Ki-67 (clone MIB-1DAKO/USA) by Envision Labelled techniques (DAKO). Results were annalyzed according to parameters based on Klaes et al. (2001) evaluating the immunomarked cell rates, the distribution through the epithelial layer and the immunoexpression intensity. The statistics analysis proceeded the study of relative risk between asymptomatic and symptomatic patients regarding to its cellular immunoexpression (nuclear, cytoplasmic or both), the more prevalent topography of the lesion (buccal mucosa and tongue) and clinical characteristics (atrophic and reticular types). RESULTS: the correlation between asymptomatic and symptomatic patients was statistically significant (p<0.05) when comparison was made of the distribution of p16 throug the epithelial layer by analysis its cellular imumunoexpression. The nuclear immunoexpression of p16 showed an odds ratio of 4.091. The nuclear and cytoplasmatic were 5.179. The odds ratio for cytoplasmatic expression was 8.461. The correlation between immunoexpression and topography resulted in an odds ratio of 5.130 for tongue and 14.234 for buccal mucosa. The other categories availed as percentage and intensity of the p16 immunoexpression, clinical characteristics, besides the Ki-67 results gave non significant results. CONCLUSIONS: The citoplasmatic expression results indicates that this immunoexpression must not be discarded, as suggested by some studies. The high relative risk saw in buccal mucosa rather than tongue was an unexpected result, because the localization pointed as with greater involvement in cases of malignat transformation is the tongue. The distribution was the only one that reached a statistically significant result, so further studies must be made in order to include or exclude the human papillomavirus presence in oral lichen planus lesions, since the p16 protein is currently nowadays used as an indicator of cellular abnormalities in cervical lesions, where its overexpression is related to the presence of high risk human papillomavirus, beyond study of p16 in the cases of liquenoid dysplasia.
Silva, Francisco Ordelei Nascimento da. „Estudo cinÃtico da reaÃÃo dos complexos cis-[Ru(bpy)2ImN(NO)](PF6)3 e cis-[Ru(bpy)2SO3NO](PF6) com redutores biolÃgicos“. Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1699.
Der volle Inhalt der QuelleO Ãxido nÃtrico (NO) à uma espÃcie endÃgena responsÃvel pela dilataÃÃo dos vasos sanguÃneos, sendo tambÃm ativo no cÃrebro e em outros processos fisiolÃgicos. Doadores de NO sÃo substÃncias farmacologicamente ativas que liberam espontaneamente ou sÃo metabolizadas. Nitroprussiato de sÃdio, Na2[Fe(CN)5NO].2H2O, faz parte de uma classe de compostos que liberam NO espontaneamente e à o Ãnico complexo metÃlico usado clinicamente. Problemas associados com o uso de nitroprussiato incluem suscetibilidade a fotÃlise e aÃÃo oxidativa do sistema imune, no qual conduz à liberaÃÃo de cianeto. Neste trabalho foi realizado o estudo e acompanhamento cinÃtico da reaÃÃo dos complexos cis-[Ru(bpy)2LNO](PF6)n (L = imidazol e sulfito) com cisteÃna, glutationa, metionina e histidina, para a obtenÃÃo de dados cinÃticos e espectroscÃpicos que possam contribuir para a elucidaÃÃo de seu mecanismo de aÃÃo. Os resultados cinÃticos para a reaÃÃo dos nitrosilo complexos com a cisteÃna e glutationa sugerem que hà formaÃÃo de dois intermediÃrios: o primeiro com banda de absorÃÃo em 450 nm à referente ao ataque do enxofre dos tiÃis e o Ãxido nÃtrico. O segundo intermediÃrio com banda de absorÃÃo caracterÃsticas em 380 nm se deve ao ataque da segunda molÃcula dos redutores ao aduto formado. As constantes de velocidade da reaÃÃo com cisteÃna apresentaram dependÃncia com relaÃÃo ao pH. Isto ocorre, provavelmente, devido à desprotonaÃÃo no enxofre da cisteÃna, facilitando a interaÃÃo deste tiÃl com o Ãxido nÃtrico coordenado ao rutÃnio (II).As reaÃÃes com metionina e histidina mostram que nÃo hà o aparecimento dos intermediÃrios, devido à ausÃncia do grupo SH nos aminoÃcidos. O acompanhamento realizado com HPLC nos mostra a existÃncia do mesmo mecanismo entre os complexos cis-[Ru(bpy)2SO3NO](PF6) e cis- [Ru(bpy)2ImN(NO)](PF6)3 com cisteÃna e glutationa. No caso da interaÃÃo com metionina e histidina, ocorre à diminuiÃÃo do pico referente aos nitrosilos complexos e o aparecimento do pico atribuÃdo ao aqua complexo. Os resultados obtidos com o eletrodo seletivo de NO, de ressonÃncia paramagnÃtica de elÃtrons e RMN, mostraram que o Ãxido nÃtrico à reduzido e liberado nos complexo sem que haja a formaÃÃo do nitrosotiÃl. Baseado em estudos cinÃticos e no espectro de EPR, a reaÃÃo dos nitrosilo complexos com cisteÃna e glutationa apresenta o seguinte esquema de reduÃÃo e liberaÃÃo do Ãxido nÃtrico:
The oxide nitric (NO) is a responsible endogenous species by dilation of the blood vessels, being also active in the brain and in other physiologic processes. Donors of NO are pathophysiologically active healthy substances that liberate spontaneously or they are metabolized. Sodium nitroprusside, Na2[Fe(CN)5NO].2H2O, is part of a class of compounds that liberate NO spontaneously and it is the only metallic compound used clinically. Associated problems with the use of nitroprusside include susceptibility the photolysis and oxidative action of the immune system, in which it leads to the liberation of cyanide. In this work it was accomplished the study and kinetic monitoring of the reaction of the compounds cis-[Ru(bpy)2LNO](PF6)n (L = imidazole and sulphite) with cysteine, glutathione, methionine and histidine, for the obtaining of kinetic and spectroscopic data that can contribute to the elucidation of your action mechanism. The kinetic results for the reaction of the nitrosyl complex with the cysteine and glutathione suggest that there is two intermediates formation: the first with absorption band in 450 nm is regarding the attack of the sulfur of the thiols and the nitric oxide. The second intermediate with characteristics band of absorption in 380 nm is due to the attack of the second molecule of the reducers to the formed adduct. The rate constants of the reaction with cysteine presented dependence regarding the pH. This occurs, probably, due to the deprotonated in the sulfur of the cisteÃna, facilitating the interaction of this thiol with the coordinated nitric oxide to the ruthenium (II). The reactions with methionine and histidine show that there are not the intermediates, due to the absence of the group SH in the amino acids. The monitoring accomplished with HPLC reveal the existence of the same mechanism among the compounds cis-[Ru(bpy)2SO3NO](PF6) and cis- [Ru(bpy)2ImN(NO)](PF6)3 with cysteine and glutathione. In the case of the interaction with methionine and histidine, occurs the decrease of the peak regarding the nitrosyl complex and the appearance of the peak attributed to the aqua complex. The obtained results with the NO sensor, of electron paramagnetic resonance and RMN, they showed that the nitric oxide is reduced and release in the complex without there is the formation of the nitrosothiol. Based on kinetic studies and in the spectrum of EPR, the reaction of the nitrosyl complex with cysteine and glutathione presents the following reduction scheme and liberation of the nitric oxide:
Moro, Roselei Bertoldo. „Estudo por espectroscopia Mossbauer de complexos [Fe (TPEN)X3, (X=3CIO4-, PF6-e B04-) E[Fe (TPEN)] y2, (y=CIO4-e PF6-)“. reponame:Repositório Institucional da UFSC, 1996. http://repositorio.ufsc.br/xmlui/handle/123456789/76990.
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Silva, Francisco. „Estudo cinético da reação dos complexos cis-[Ru(bpy)2ImN(NO)](PF6)3 e cis-[Ru(bpy)2SO3NO](PF6) com redutores biológicos“. reponame:Repositório Institucional da UFC, 2008. http://www.repositorio.ufc.br/handle/riufc/1283.
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The oxide nitric (NO) is a responsible endogenous species by dilation of the blood vessels, being also active in the brain and in other physiologic processes. Donors of NO are pathophysiologically active healthy substances that liberate spontaneously or they are metabolized. Sodium nitroprusside, Na2[Fe(CN)5NO].2H2O, is part of a class of compounds that liberate NO spontaneously and it is the only metallic compound used clinically. Associated problems with the use of nitroprusside include susceptibility the photolysis and oxidative action of the immune system, in which it leads to the liberation of cyanide. In this work it was accomplished the study and kinetic monitoring of the reaction of the compounds cis-[Ru(bpy)2LNO](PF6)n (L = imidazole and sulphite) with cysteine, glutathione, methionine and histidine, for the obtaining of kinetic and spectroscopic data that can contribute to the elucidation of your action mechanism. The kinetic results for the reaction of the nitrosyl complex with the cysteine and glutathione suggest that there is two intermediates formation: the first with absorption band in 450 nm is regarding the attack of the sulfur of the thiols and the nitric oxide. The second intermediate with characteristics band of absorption in 380 nm is due to the attack of the second molecule of the reducers to the formed adduct. The rate constants of the reaction with cysteine presented dependence regarding the pH. This occurs, probably, due to the deprotonated in the sulfur of the cisteína, facilitating the interaction of this thiol with the coordinated nitric oxide to the ruthenium (II). The reactions with methionine and histidine show that there are not the intermediates, due to the absence of the group SH in the amino acids. The monitoring accomplished with HPLC reveal the existence of the same mechanism among the compounds cis-[Ru(bpy)2SO3NO](PF6) and cis- [Ru(bpy)2ImN(NO)](PF6)3 with cysteine and glutathione. In the case of the interaction with methionine and histidine, occurs the decrease of the peak regarding the nitrosyl complex and the appearance of the peak attributed to the aqua complex. The obtained results with the NO sensor, of electron paramagnetic resonance and RMN, they showed that the nitric oxide is reduced and release in the complex without there is the formation of the nitrosothiol. Based on kinetic studies and in the spectrum of EPR, the reaction of the nitrosyl complex with cysteine and glutathione presents the following reduction scheme and liberation of the nitric oxide:
O óxido nítrico (NO) é uma espécie endógena responsável pela dilatação dos vasos sanguíneos, sendo também ativo no cérebro e em outros processos fisiológicos. Doadores de NO são substâncias farmacologicamente ativas que liberam espontaneamente ou são metabolizadas. Nitroprussiato de sódio, Na2[Fe(CN)5NO].2H2O, faz parte de uma classe de compostos que liberam NO espontaneamente e é o único complexo metálico usado clinicamente. Problemas associados com o uso de nitroprussiato incluem suscetibilidade a fotólise e ação oxidativa do sistema imune, no qual conduz à liberação de cianeto. Neste trabalho foi realizado o estudo e acompanhamento cinético da reação dos complexos cis-[Ru(bpy)2LNO](PF6)n (L = imidazol e sulfito) com cisteína, glutationa, metionina e histidina, para a obtenção de dados cinéticos e espectroscópicos que possam contribuir para a elucidação de seu mecanismo de ação. Os resultados cinéticos para a reação dos nitrosilo complexos com a cisteína e glutationa sugerem que há formação de dois intermediários: o primeiro com banda de absorção em 450 nm é referente ao ataque do enxofre dos tióis e o óxido nítrico. O segundo intermediário com banda de absorção características em 380 nm se deve ao ataque da segunda molécula dos redutores ao aduto formado. As constantes de velocidade da reação com cisteína apresentaram dependência com relação ao pH. Isto ocorre, provavelmente, devido à desprotonação no enxofre da cisteína, facilitando a interação deste tiól com o óxido nítrico coordenado ao rutênio (II).As reações com metionina e histidina mostram que não há o aparecimento dos intermediários, devido à ausência do grupo SH nos aminoácidos. O acompanhamento realizado com HPLC nos mostra a existência do mesmo mecanismo entre os complexos cis-[Ru(bpy)2SO3NO](PF6) e cis- [Ru(bpy)2ImN(NO)](PF6)3 com cisteína e glutationa. No caso da interação com metionina e histidina, ocorre à diminuição do pico referente aos nitrosilos complexos e o aparecimento do pico atribuído ao aqua complexo. Os resultados obtidos com o eletrodo seletivo de NO, de ressonância paramagnética de elétrons e RMN, mostraram que o óxido nítrico é reduzido e liberado nos complexo sem que haja a formação do nitrosotiól. Baseado em estudos cinéticos e no espectro de EPR, a reação dos nitrosilo complexos com cisteína e glutationa apresenta o seguinte esquema de redução e liberação do óxido nítrico:
Sabatier, Laetitia. „Differential p97 adaptors and their role in cellular functions“. Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101739.
Der volle Inhalt der QuelleChalk, Kieran. „Weld consumables and PWHT for P92 power plant steel“. Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/14572/.
Der volle Inhalt der Quelle文偉倫 und Wai-lun Matthew Man. „p15 and p16 genes in head and neck carcinoma“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31224945.
Der volle Inhalt der QuelleMoore, Madeleine. „Activating senescence in p16-positive Basal-like breast cancer“. Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/12985.
Der volle Inhalt der QuelleWiseman, Katherine. „Characterisation of a new p97 adaptor in genome stability“. Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:24e23965-ac0b-4fd9-8928-990df307b52f.
Der volle Inhalt der QuelleSkocki, Radosław. „Badania wpływu temperatury podwyższonej na właściwości cykliczne stali P91“. Rozprawa doktorska, Uniwersytet Technologiczno-Przyrodniczy w Bydgoszczy, 2016. http://dlibra.utp.edu.pl/Content/957.
Der volle Inhalt der QuelleSimpson, David S. „Role of Rb/p16 Pathway in Pulmonary Epithelial Regulation“. University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291148417.
Der volle Inhalt der QuelleKita, Ryuichi. „INFREQUENT ALTERATIONS OF THE p16^ GENE IN LIVER CANCER“. Kyoto University, 1998. http://hdl.handle.net/2433/182241.
Der volle Inhalt der QuelleWong, David J. S. „Methylation of the p16 CpG island during neoplastic progression /“. Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5074.
Der volle Inhalt der QuelleMan, Wai-lun Matthew. „P15 and p16 genes in head and neck carcinoma /“. Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23436001.
Der volle Inhalt der QuelleEmery, Nathan J. „Neuroethological studies of primate social perception“. Thesis, University of St Andrews, 1997. http://hdl.handle.net/10023/15078.
Der volle Inhalt der QuelleHülsmann, Julia [Verfasser], und Hemmo [Akademischer Betreuer] Meyer. „A systematic proteomic approach to the VCP/p97-cofactor interaction landscape reveals p97 functions in stress response signaling / Julia Hülsmann ; Betreuer: Hemmo Meyer“. Duisburg, 2020. http://d-nb.info/120726993X/34.
Der volle Inhalt der QuelleJensen, Anaïs. „Étude de p76, une nouvelle protéine mannose-6-phosphate : caractérisations biochimiques, localisation lysosomale et approche de la fonction“. Grenoble 1, 2007. http://www.theses.fr/2007GRE10047.
Der volle Inhalt der QuelleThe protein « p76 » (« hypothetical protein LOC196463 ») was identified some years ago in our laboratory during the course of a proteomic analysis of mannose-6-phosphate proteins purified from human cell lines. The present thesis describes the biochemical characterisation and the intracellular localisation of p76, as well as some functional tests carried out with recombinant p76. We demonstrated that human p76 sequence bears 6 N-glycosylations and that mannose-6-phosphate sugars were present. Proteolytic maturation of human and murine p76 precursors was observed; a few intermediate forms were partially characterised thanks to anti-p76 antibodies which were developed in the laboratory. Most importantly, we were able to demonstrate the lysosomal localisation of this protein by both immunofluorescence and sub-cellular fractionation of mouse liver homogenates. As p76 shows a significant sequence homology to a recently cloned phospholipase B from Dictyostelium discoideum, some functional tests were performed, but no phospholipase activity could be detected with recombinant hp76-myc. However, a fat blot experiment showed that hp76-myc binds cardiolipin, a particular phospholipid enriched in mitochondrial and bacterial membranes
Vähä-Heikkilä, Tauno. „MEMS tuning and matching circuits, and millimeter wave on-wafer measurements /“. Espoo VTT, 2006. http://www.vtt.fi/inf/pdf/publications/2006/P596.pdf.
Der volle Inhalt der QuelleHäkkinen, Suvi T. „A functional genomics approach to the study of alkaloid biosynthesis and metabolism in Nicotiana tabacum and Hyoscyamus muticus cell cultures /“. [Espoo, Finland] : VTT, 2008. http://www.vtt.fi/inf/pdf/publications/2008/P696.pdf.
Der volle Inhalt der QuelleMariano, Carolline Fontes Alves. „Estudo da frequência de infecção pelo vírus do papiloma humano (HPV) e da expressão de p16 e p53 nas neoplasias intraepiteliais e no carcinoma invasivo da superfície ocular“. Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-20072018-093128/.
Der volle Inhalt der QuelleOcular surface squamous neoplasia (OSSN) is one the most frequent lesions involving the conjunctiva or cornea and its main risk factors are solar exposure (ultraviolet radiation), human papilloma virus (HPV) infection and immunodeficiency states, especially human immunodeficiency virus (HIV) infection. In advanced cases one can observe eyeball or orbital infiltration and, rarely, lymph node or distant metastases. The present study aimed to investigate the clinical and histopathological data, as well as the presence of HPV and the expression of proteins p16 e p53 in 45 cases of OSSN diagnosed at the Clinics Hospital of Ribeirão Preto Medical School, University of São Paulo, from 2005 through 2015. Histopathological examination, immunohistochemical study for proteins p16 and p53, and chromogenic in situ hybridization (CISH) for low and high grade HPV were performed in all samples. Lesions were more frequent in white males, above 40 years old. Histopathological examination revealed 31 cases (69%) of invasive carcinoma and 14 cases (31%) of carcinoma in situ. In 6 cases (13%) high grade HPV was detected by CISH. The expressions of p53 and p16 were high, 89% and 53%, respectively. In our study, increased incidence of OSSN was observed in white males, above 40 years old, with high grade HPV in 13% of the cases. The expression of p16 did not show a high positive predictive value for HPV positivity in OSSN.
Rauch, Josepha [Verfasser], und Philipp [Akademischer Betreuer] Baumeister. „Analyse möglicher Faktoren für die bessere Prognose p16-positiver primär operativ behandelter oropharyngealer Plattenepithelkarzinome verglichen mit p16-negativen Karzinomen / Josepha Rauch ; Betreuer: Philipp Baumeister“. München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1164377132/34.
Der volle Inhalt der QuelleVoss, Martin Henner. „p16-INK4a controls the morphology program associated with cellular senescence“. [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976851105.
Der volle Inhalt der QuelleRabien, Anja. „Molekulare Mechanismen der p16-vermittelten Anoikisinduktion in humanen Pankreaskarzinom-Zellen“. [S.l.] : [s.n.], 2003. http://www.diss.fu-berlin.de/2004/131/index.html.
Der volle Inhalt der QuelleTang, Kit Shing. „Stability, folding and evolution of the tumour suppressor protein p16“. Thesis, University of Cambridge, 2001. https://www.repository.cam.ac.uk/handle/1810/251785.
Der volle Inhalt der QuelleNousch, Marco Biotechnology & Biomolecular Sciences Faculty of Science UNSW. „The role of the translational regulator p97 in mammalian cells“. Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41445.
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