Zeitschriftenartikel: „P75 2004“

1

Foss, Francine, Marie France Demierre und Gina DiVenuti. „A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma“. Blood 106, Nr. 2 (15.07.2005): 454–57. http://dx.doi.org/10.1182/blood-2004-11-4570.

Der volle Inhalt der Quelle

Annotation:

Abstract Denileukin diftitox, a genetically engineered fusion protein combining the enzymatically active domains of diphtheria toxin and the full-length sequence for interleukin-2 (IL-2), efficiently targets lymphoma cells expressing the high-affinity IL-2 receptor (IL-2R) consisting of the α/p55/CD25, β/p75/CD122, and γ/p64/CD132 chains. In vitro studies demonstrated that the retinoid X receptor (RXR) retinoid, bexarotene, at biologically relevant concentrations of 10–6M to 10–8 M, upregulated both the p55 and p75 subunits of the IL-2R and enhanced 5- to 10-fold the susceptibility of T-cell leukemia cells to denileukin diftitox. To determine whether this biomodulatory effect could be recapitulated in vivo, we treated 14 patients with relapsed or refractory cutaneous T-cell lymphoma with escalating doses of bexarotene (75 mg/day-300 mg/day) and denileukin diftitox (18 mcg/kg per day × 3 days every 21 days) in a phase 1 trial. Overall response was 67% (4 complete responses, 4 partial responses). Modulation of IL-2R expression was observed at or above a bexarotene dose of 150 mg/day. Four patients experienced grade 2 or 3 leukopenia, and 2 had grade 4 lymphopenia. Our results demonstrate that the combination of denileukin diftitox and bexarotene is well tolerated and that even low doses (150 mg/day) of bexarotene are capable of in vivo upregulation of CD25 expression on circulating leukemia cells.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

2

Felbar, Daniel, Vilijam Zdravkovic und Bernhard Jost. „Demographic changes and surgery caseloads for hip arthroplasty over the last 50 years: a retrospective study“. Swiss Medical Weekly 153, Nr. 3 (03.03.2023): 40047. http://dx.doi.org/10.57187/smw.2023.40047.

Der volle Inhalt der Quelle

Annotation:

AIMS OF THE STUDY: Data on the demographic changes over time for hip arthroplasty are rare in Switzerland. The aim of the study was to evaluate the influence of these changes on the distribution of age, gender, operated hip side, place of residence and caseload per surgeon over the last 50 years of hip arthroplasty at the Kantonsspital St. Gallen. METHODS: For this retrospective explorative study, data were collected from the operating theatre journals of hip replacements performed at Kantonsspital St. Gallen from 1969 to 2019. Every fifth year was included, which resulted in 5-year sampling rate over the observation period. The journals were handwritten until 1999 and digital from 2004 to 2019. The following data were obtained: age, sex, type of hip arthroplasty, side of operated hip, place of residence and name of main surgeon. Apart from overall descriptive statistics, we applied the Mann-Whitney U-test to test for differences in age and the binomial test for categorical variables. A linear regression model was applied to investigate the relationship between patients’ ages and historical data of life expectancy of the Swiss population. RESULTS: We included 2,963 patients, of whom 1,318 were men (median age = 67 yr., p25 = 59 yr., p75 = 74 yr.) and 1,608 women (median age = 72 yr., p25 = 63 yr., p75 = 79 yr.). Overall, women were significantly older than men, irrespective of whether they received primary total hip arthroplasty (median age = 70 yr. vs 66 yr., p25 = 61 yr. vs 58 yr., p75 = 77 yr. vs 73 yr., p <0.001), hemiarthroplasty (median age = 84 yr. vs 78.5 yr., p25 = 78 yr. vs 71 yr., p75 = 89 yr. vs 85 yr., p <0.001) or total revision arthroplasty (median age = 71 yr. vs 70 yr., p25 = 64.25 yr. vs 63 yr., p75 = 78 yr. vs 75 yr., p = 0.036). A trend toward rising median age is evident looking at the whole period observed from 1969 to 2019. Except for women in the total revision arthroplasty group (r = 0.226), a high correlation between increasing median age of patients undergoing hip replacement and life expectancy was found (r ≥0.663). Significantly more primary total hip prostheses (p = 0.003) and hip hemiprostheses (p <0.001) were implanted in women than in men between 1969 and 2019. Overall, no significant difference in side distribution was seen in the primary total hip arthroplasty (p = 0.061), total revision arthroplasty (p = 1.000) and hemiarthroplasty (p = 0.365) group. In contrast to earlier years, most patients in recent years are operated on by high-volume surgeons (>50 operations per surgeon per year). CONCLUSIONS: Demographic changes of patients undergoing total hip replacement reflect the overall demographic changes in the Swiss population. Over the last 50 years the indication for prosthetic hip replacements has not been extended to younger ages. The caseload in hip arthroplasty has changed over the last 50 years towards high-volume surgeons.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

3

Novella-Navarro, M., J. L. Cabrera-Alarcón, J. L. Rosales, J. J. González Martin, P. García de la Peña und O. Carrion. „AB0437 RISK FACTORS ASESSMENT FOR SUBCLINICAL ARTHEROSCLEROSIS IN PRIMARY SJÖGREN´S SYNDROME.“ Annals of the Rheumatic Diseases 79, Suppl 1 (Juni 2020): 1517.2–1518. http://dx.doi.org/10.1136/annrheumdis-2020-eular.989.

Der volle Inhalt der Quelle

Annotation:

Background:Some autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are considered to be independent risk factors for vascular morbidity and mortality. These pathologies present accelerated atherosclerosis, partly because of a chronic sustained inflammation, greater prevalence of cardiovascular risk factors (CVRFs) and pharmacological therapy. However, regarding primary Sjögren’s syndrome (pSS), available data are heterogeneous and proceed from small case series. For this reason, the aim of this study was to provide further information on the identification of atherosclerosis in pSS and its possible association with clinical and analytical parameters of the disease.Objectives:To assess presence of subclinical atherosclerosis by means of carotid ultrasound in patients with pSS and to analyze clinical, analytical and CVRF along with their potential association with the presence of subclinical cardiovascular affectation.Methods:This is a cross-sectional study of 38 patients with pSS (all patients met ACR/EULAR1classification criteria for pSS) and 38 age and sex matched controls. Demographic variables and classical CVRFs were collected (Hypertension, Diabetes mellitus, dyslipemia, Body Mass Index and smoking habit) and the presence of subclinical atherosclerosis was assessed by carotid ultrasound with carotid intima-media thickness (CIMT) measurement and determination of the presence of atheromatous plaques2, both in pSS patients and controls. Disease features were also collected in pSS patients (disease duration, disease activity measured by ESSDAI, glandular vs extraglandular involvement, serological features and treatments received).Statistical analysis: To evaluate differences between patients and controls, T-test or Wilcoxon test with continuity correction, were used for quantitative features and Fisher test for categorical variables. In order to test the presence of pSS as an independent risk factor for subclinical atherosclerosis, from other features as classic CVRFs or analytical data, first we adjusted logistic binomial regression in a bivariate analysis, to select possible predictors to be included in a multivariate analysis. Statistical significance was p<0.05, and OR CI 95% vas calculated.R-Statistics v- 3.6Table 1.Comparison of clinical data of two case groups and healthy control group M (p25, p75)GroupsCase group ACase group BHealthy control groupH valueP valueHistory of thrombus (case)4a8a-13.7090.001History of adverse pregnancy (case)3a19a-34.596<0.001ESR20.00(12.25,111.00)a35.00(14.25,95.00)a9.00(6.00,13.00)34.381<0.001CRP15.00(4.03,37.83)ab7.33(1.76,21.13)ab2.10(1.28,2.31)35.263<0.001PLT228.00(189.50,573.25)ab197.00(66.00,260.50)ab258.50(228.25,272.25)33.482<0.001Note:aComparison with healthy control groupP< 0.05;bComparison with case groupP<0.05.Table 2.Comparison of lymphocyte subsets in peripheral blood of two case groups and healthy control group M (p25, p75)Results:All of the 76 patients included were women, with a mean age of 53.7 ± 11.7 years. For both groups, no differences between prevalence of classical CVRFs were found. Subclinical atherosclerosis presence was higher in patients with pSS than in controls [OR= 4.17, 95%CI (1.27- 16.54), p<0.001], as well as CIMT values (0.79± 0.43 mm vs. 0.66 ± 0.27 mm; p=0.02). An association of subclinical atherosclerosis with erythrocyte sedimentation rate [OR=1.18, 95%CI (1.05-1.37), p<0.05] and Rheumatoid Factor [OR=1.28, 95%CI (1.63-2.26), p<0.05].Conclusion:This cohort showed a greater prevalence of subclinical atherosclerosis in patients with pSS, indicating this disease as an independent risk factor for presence of early vascular damage.References:[1]Vitali C et al. Classification Criteria for Sjögren Syndrome: a revised version of the European criteria proposed by the American-European Consensous Group. Ann Rheum Dis. 2002; 61: 554-8[2]Touboul PJ et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis. 2012; 34: 290-6Disclosure of Interests:Marta Novella-Navarro: None declared, José Luis Cabrera-Alarcón: None declared, José Luis Rosales Grant/research support from: I have received financial support from Novartis, UCB, Pfizer, Abvie to meeting and symposia, Jorge Juan González Martin Grant/research support from: I have received finacial grants from Novartis, Lilly, Pfizer, Abvie for meetings and symposia assistance, Paloma García de la Peña Grant/research support from: I have received finacial grants from Novartis, Lilly, Pfizer, Abvie for meetings and symposia assistance, Ofelia Carrion: None declared

APA, Harvard, Vancouver, ISO und andere Zitierweisen

4

Previati, Sabrina Monique, Daniel Malingre Vieira und Marcia Barbieri. „A importância do aconselhamento no exame rápido de HIV em gestantes durante o pré-natal“. Journal of Health & Biological Sciences 7, Nr. 1 (28.12.2018): 75. http://dx.doi.org/10.12662/2317-3076jhbs.v7i1.2104.p75-81.2019.

Der volle Inhalt der Quelle

Annotation:

Introdução: o aumento do número de casos de gestantes infectadas com o HIV é preocupante, entre as estratégias fomentadas para redução da transmissão vertical o aconselhamento pré-teste rápido de HIV apresenta-se como importante medida preventiva. Objetivo: Demonstrar, por meio de revisão da literatura, a importância do aconselhamento no teste rápido de HIV em gestantes. Método: estudo descritivo com pesquisa de revisão bibliográfica realizado por meio de artigos e publicações científicas encontradas nas bases de dados SCIELO, LILACS, CAPES e PUBMED com abrangência temporal de 2004 a 2018, utilizando-se os seguintes descritores: HIV, Aconselhamento, Teste rápido, Gestantes, Pré-Natal, em português e inglês. Resultados: obtiveram-se 18 artigos relacionados ao tema, utilizados após criteriosa seleção em revisão bibliográfica integrativa que foram utilizados como base teórica para a discussão acerca do tema do trabalho. Conclusão: observou-se que, além da necessidade em agilizar o diagnóstico, deve-se também fornecer as orientações necessárias pré e pós teste das gestantes atendidas para que o atendimento as esclareça de modo a priorizar medidas profiláticas na prevenção da doença e, no caso de positividade do resultado do exame, reduzir a transmissão vertical e estimular o seguimento do tratamento da condição patológica, além de estabelecer vínculos com o paciente visando à promoção de seu autocuidado.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

5

Galarza-Delgado, D. Á., I. J. Colunga-Pedraza, J. R. Azpiri-López, V. M. Beltran-Aguilar, V. Gonzalez-Gonzalez, A. G. Arias Peralta, N. De Avila Gonzalez, J. A. Cardenas-de la Garza und G. García-Arellano. „AB0261 PREVALENCE OF HEART VALVULAR REGURGITATION ACCORDING TO THE TIME OF DISEASE EVOLUTION IN RHEUMATOID ARTHRITIS PATIENTS“. Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 1313.2–1313. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2892.

Der volle Inhalt der Quelle

Annotation:

BackgroundRheumatoid arthritis (RA) patients are at higher risk of developing cardiovascular (CV) diseases, both ischemic and non-ischemic, than the general population [1]. Inflammatory status and fibrotic changes at cardiac valves in these patients predispose them to a higher risk of valve diseases, which could be detected by echocardiography [2].ObjectivesTo determine the prevalence of valvular regurgitation, according to the time of disease evolution in RA patients.MethodsDescriptive, comparative, and cross-sectional study. We enrolled RA patients between 40 and 75 years old who fulfilled ACR/EULAR 2010 classification criteria and recruited in the Rheumatology service from tertiary care hospital. Patients were divided by time of disease evolution into quartiles. A transthoracic echocardiogram performed by a certified cardiologist blinded to clinical data. Normality was assesed by Kolmogorov-Smirnov test. Variables with normal and non-normal distribution were described by media and standard deviation, such as median and interquartile range (p25-p75), respectively. Differences between groups was analyzed by ANOVA, Kruskal-Wallis test or Chi-squared, accordingly.ResultsWe included 151 RA patients. Demographic characteristics are in Table 1. Overweight/obesity was found between 62-87% of patients, hypertension between 26-34%, and Type 2 Diabetes mellitus between 8-26%. The tricuspid valve was the most affected (73-84%). There was no differences in prevalence of valvular regurgitation.ConclusionRA patients have a high prevalence of valvular regurgitation, which could predispose them to develop heart failure, therefore it is important to consider echocardiography in the approach of this population, despite not showing an increase.References[1] Crowson CS, Liao KP, Davis JM, Solomon DH, Matteson EL, Knutson KL, et al. Rheumatoid arthritis and cardiovascular disease. Am Heart J. 2013 Oct;166(4):622-628.e1.[2] Maksimowicz-McKinnon K, Mandell BF. Understanding valvular heart disease in patients with systemic autoimmune diseases. Cleve Clin J Med. 2004 Nov 1;71(11):881–5Table 1.Demographic characteristics (n= 151)Variable1st Quartile (n= 38)2nd Quartile (n=38)3rd Quartile (n=38)4th Quartile (n=37)pDuration of disease, years. median (p25-p75)1.5 (1.0-2.0)5.0 (3.9-6.0)10.6 (9.4-12.6)20.5 (16.5-25.2)Women, (n)%37 (97)34 (89)36 (94)35 (94)NSAge, years. mean (±SD)54 (9.6)56 (8.5)55 (8.8)56 (8.0)NSComorbidities, n (%)Overweight/Obesity28 (73.7)33 (86.8)31 (81.6)23 (62.2)NSHypertension13 (34.2)13 (34.2)10 (26.3)12 (32.4)NST2DM6 (15.8)10 (26.3)8 (21.1)3 (8.1)NSValvular regurgitation, n (%)Aortic valve3 (7.9)7 (18.4)2 (5.3)8 (21.6)NSMitral valve26 (68.4)21 (55.3)17 (44.7)20 (54.1)NSPulmonary valve9 (23.7)7 (18.4)9 (23.7)8 (21.6)NSTricuspid valve28 (73.7)31 (81.6)31 (81.6)31 (83.8)NSAny of valves32 (84.2)33 (86.8)33 (86.8)31 (83.8)NSThis table shows demographic and clinical characteristics. Quartiles were divided according to rheumatoid arthritis duration, meanwhile, each variable was described individually. T2DM Type 2 Diabetes Mellitus.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

6

Chandrasekharan, Unni M., Maria Siemionow, Murat Unsal, Lin Yang, Earl Poptic, Justin Bohn, Kagan Ozer et al. „Tumor necrosis factor α (TNF-α) receptor-II is required for TNF-α–induced leukocyte-endothelial interaction in vivo“. Blood 109, Nr. 5 (26.10.2006): 1938–44. http://dx.doi.org/10.1182/blood-2006-05-020875.

Der volle Inhalt der Quelle

Annotation:

Abstract Tumor necrosis factor-α (TNF-α) binds to 2 distinct cell-surface receptors: TNF-α receptor-I (TNFR-I: p55) and TNF-α receptor-II (TNFR-II: p75). TNF-α induces leukocyte adhesion molecules on endothelial cells (ECs), which mediate 3 defined steps of the inflammatory response; namely, leukocyte rolling, firm adhesion, and transmigration. In this study, we have investigated the role of p75 in TNF-α–induced leukocyte adhesion molecules using cultured ECs derived from wild-type (WT), p75-null (p75−/−), or p55-null (p55−/−) mice. We observed that p75 was essential for TNF-α–induced E-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1) expression. We also investigated the putative role of p75 in inflammation in vivo using an intravital microscopic approach with a mouse cremaster muscle model. TNF-α–stimulated leukocyte rolling, firm adhesion to ECs, and transmigration were dramatically reduced in p75−/− mice. Transplanted WT cremaster in p75−/− mice showed a robust leukocyte rolling and firm adhesion upon TNF-α activation, suggesting that the impairment in EC-leukocyte interaction in p75−/− mice is due to EC dysfunction. These results demonstrate, for the first time, that endothelial p75 is essential for TNF-α–induced leukocyte–endothelial-cell interaction. Our findings may contribute to the identification of novel p75-targeted therapeutic approaches for inflammatory diseases.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

7

Schaafsma, A. W., M. L. Holmes, J. Whistlecraft und S. A. Dudley. „Effectiveness of three Bt corn events against feeding damage by the true armyworm (Pseudaletia unipuncta Haworth)“. Canadian Journal of Plant Science 87, Nr. 3 (01.07.2007): 599–603. http://dx.doi.org/10.4141/p05-125.

Der volle Inhalt der Quelle

Annotation:

A 3-yr study (2002-2004) was conducted to evaluate the resistance of three Bt corn events to herbivory damage by the armyworm, Pseudaletia unipuncta (Haworth). Resistance was assessed by damage ratings and fresh mass measurements. Greenhouse studies were run in 2002 and 2004, and a field study was conducted in 2003. Hybrids expressing the Cry1A(b) insecticidal protein, Mon810 and Bt176 events, and their near isolines, as well as the TC1507 event, which expresses the Cry1F protein, were evaluated. Bt hybrids suffered less damage in all 3 yr and had higher fresh masses in 2002 and 2003 than the non-transgenic isolines. In 2002 and 2003, hybrids expressing the Cry1A(b) protein were significantly less damaged than the hybrid expressing Cry1F. In both 2002 and 2004, the Mon810 event suffered less damage than the Bt176 event, despite expressing the same Cry1A(b) protein. Bt corn, especially the Mon810 event may be used as an effective method of preventing P. unipuncta herbivory damage in corn. Key words: True armyworm, Pseudaletia unipuncta, Bt corn, Cry1A(b), Cry1F, epistasis

APA, Harvard, Vancouver, ISO und andere Zitierweisen

8

Barbosa, Mariana Velloso, Rodrigo Sernizon Costa, Thaís Alves Tomita, Renata Gomes Lanna Da Silva, Harley Francisco Viana und Armando Cesar Campos Lavall. „Strength calculation of composite slabs by the partial shear connection method considering the friction“. Caderno Pedagógico 21, Nr. 2 (15.02.2024): e2728. http://dx.doi.org/10.54033/cadpedv21n2-047.

Der volle Inhalt der Quelle

Annotation:

This paper aims to evaluate the behavior and longitudinal shear strength of the steel-concrete composite slab using the Steel Deck P75 through the partial shear connection method considering the contribution of the friction acting in the interface of the steel deck with the concrete at the region of supports. The method proposed by EN 1994-1-1:2004 for the design of composite slab systems is based in the analytical model similar to that of composite beams which allows to determine the degree shear connection between the steel sheeting and the concrete. This method allows to analyse the influence of friction at the support, in addition to the contribution of stud bolts on the mechanical resistance of composite slab. The composite slab was tested in the Federal University of Minas Gerais structure laboratory which used the semi-empirical "m-k" method to obtain its resistance. The behavior of the composite slab system was analysed through of the graphics deflections, end slips and strains, allowing the determination of its failure mode. Finally, the results obtained from the longitudinal shear resistance considering the friction at the support were applied in one practical example.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

9

Bencivenga, Maria, Lorena Torroni, Mariagiulia Dal Cero, Alberto Quinzii, Camilla Zecchetto, Valeria Merz, Simona Casalino et al. „YAP Activation Is Associated with a Worse Prognosis of Poorly Cohesive Gastric Cancer“. Journal of Personalized Medicine 13, Nr. 9 (24.08.2023): 1294. http://dx.doi.org/10.3390/jpm13091294.

Der volle Inhalt der Quelle

Annotation:

Poorly cohesive (PC) gastric cancer (GC) is extremely aggressive in progression, and there is an urgent need to identify the molecular pathways involved. We hypothesized the essential role of the RhoA–YAP axis in these mechanisms. The present observational multicenter retrospective study included 133 patients with PC GC treated at two dedicated European surgical centers between 2004 and 2014. YAP nuclear localization was measured by immunohistochemical (IHC) analysis of tissue biopsies. The complete absence of nuclear reactivity was coded as negative expression; we considered “any positive” as low nuclear expression (>0% but <10% of cells) and high nuclear expression (≥10% of cells). Women represented about half of the present series (52%), and the median age was 64 years (p25–p75 range: 53–75). Neoadjuvant and adjuvant treatments were administered to 10% and 54% of the cases, respectively. Extended systemic lymphadenectomy (D2) was the most common (54%). In nearly all cases, the number of retrieved nodes was ≥15, i.e., adequate for tumor staging (94%). An R0 resection was achieved in 80% of the cases. Most patients were pathological T stage 3 and 4 (pT3/pT4 = 79.0%) and pathological N stage 2, 3a, and 3b (pN2/pN3a/pN3b = 47.0%) at the pathological examination. Twenty patients (15%) presented distant metastases. Five-year overall survival (OS) was significantly higher (p = 0.029) in patients with negative YAP (46%, 95% CI 31.1–60.0%) than in the other patients (27%, 17.5–38.1%). Moreover, when controlling for sex, age, pT, pN, and percentage of signet ring cells in the multivariable analysis, YAP expression was a significant predictor of OS (HR 2.03, 95% CI: 1.18–3.51, p = 0.011). Our results provide new insights into the role of the YAP signaling cascade, as its activation was associated with a worse prognosis in PC GC.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

10

Golembiewski, Carlos, und Pamella Cristina Rodrigues da Silva. „KLARA CASTANHO NAS REDES SOCIAIS:“. Vozes e Diálogo 21, Nr. 1 (27.07.2023): 15–33. http://dx.doi.org/10.14210/vd.v21n1.p15-33.

Der volle Inhalt der Quelle

Annotation:

Este artigo tem o objetivo de analisar como o caso da atriz Klara Castanho ocorrido em maio de 2022 foi noticiado nas redes sociais. A atriz foi vítima de violência sexual que culminou numa gravidez indesejada e posterior doação da criança. O referencial teórico é composto pelas seguintes noções: Jornalismo Digital (Pereira, 2004; Traquina, 2005); Ética Jornalística (Christofoletti, 2008; Karam, 2009); e Violência contra a mulher (Teles, Melo, 2002); Em relação à metodologia, utilizou-se a Pesquisa Documental do tipo qualitativa para observar a forma que o caso foi retratado no Instagram, no TikTok e no Twitter. Os resultados da pesquisa revelam que de houve erros jornalísticos e éticos na condução do caso, o que gerou impactos na vida da atriz.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

11

Braga, Clara S. C., und Jose Carlos Lázaro. „LEIS ESTADUAIS COMPLEMENTARES À LEI DE INOVAÇÃO FEDERAL: IMPACTO SOBRE A IMPLEMENTAÇÃO DE INOVAÇÃO NAS INDÚSTRIAS DOS ESTADOS BRASILEIROS“. Revista Gestão em Análise 9, Nr. 3 (29.12.2020): 35. http://dx.doi.org/10.12662/2359-618xregea.v9i3.p35-50.2020.

Der volle Inhalt der Quelle

Annotation:

Este estudo tem como objetivo investigar se a adoção de leis de inovação complementares pelos estados impactou a implementação de inovações por parte da indústria local. A pesquisa é descritiva, com a utilização de dados da Pesquisa de Inovação – IBGE (PINTEC), nos triênios de 2000, 2003, 2005, 2008 e 2011. Para a comparação do desempenho inovativo entre estados, é utilizada a técnica de ANOVA para medidas repetidas. Os resultados demonstraram que 12 dos 14 estados apresentaram redução no número de empresas que implementaram inovação entre 2008 e 2011. Evidenciou-se, ainda, que não há diferençasignificativa na implementação de inovações por parte da indústria local nos estados que possuem leis complementares de inovação e aqueles que ainda não as implementaram.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

12

Akanda, MA Razzaque, M. Shahabuddin Ahamad, MS Rahman, GMA Halim und MM Hasan. „Performance evaluation of fertigation and micronutrients on fruit yield and quality of summer tomato (Lycopersicon esculentum L.)“. Bangladesh Journal of Agricultural Research 37, Nr. 3 (07.10.2012): 449–56. http://dx.doi.org/10.3329/bjar.v37i3.12088.

Der volle Inhalt der Quelle

Annotation:

Fertigation was found technically and economically feasible for tomato cultivation in winter as well as in summer. An experiment was conducted with summer tomato (BARI Hybrid Tomato4) having 2 drip irrigation levels with different levels of NPK and micronutrient (B, Zn, and Mg) during kharif-1 seasons of 2007 and 2008. The fertilizer levels were N100 P55 K120 kg/ha, N100 P55 K120 B1 Zn4 Mg4 kg/ha, N100 P70 K140 kg/ha and N100 P70 K140 B2 Zn6 Mg8 kg/ha and the irrigation levels were drip irrigation at 2 days interval and drip irrigation at 3 days interval. The highest marketable yield of summer tomato (35.90 t/ha and 27.12 t/ha) were obtained from the fertigation treatment with fertilizer doses of N100 P55 K120 B1 Zn4 Mg4 kg/ha irrigated at 2 days interval in 2007 and 2008. The cull yield was also the lowest (2.53 t/ha and 1.15 t/ha) in this treatment in both the years. The lowest tomato yield (20.50 t/ha and 18.29 t/ha) were obtained from the treatment with fertilizer doses N100 P70 K140 kg/ha irrigated at 2 days interval where no micronutrients were used. Fruit quality parameters like TSS, Vitamin-C and ?-carotene were also the highest for the best yielder. So, use of micronutrients with NPK showed a significant effect on quality fruits as well as yield of summer tomato. The best yielder treatment received 261.0 mm of seasonal water including an effective rainfall of 60.5 mm during the crop seasons. The highest BCR (4.41) was also found in the same treatment. Bangladesh J. Agril. Res. 37(3): 449-456, September 2012 DOI: http://dx.doi.org/10.3329/bjar.v37i3.12088

APA, Harvard, Vancouver, ISO und andere Zitierweisen

13

Soares, Livia Maria Rosa, Ismael Arruda Machado Da Silva und Vilmaria Chaves Nogueira. „Opressão e libertação na escrita feminina entre os séculos XIX e XXI“. Letras Escreve 9, Nr. 2 (02.03.2020): 57. http://dx.doi.org/10.18468/letras.2019v9n2.p57-67.

Der volle Inhalt der Quelle

Annotation:

Este trabalho pretende analisar a representações de gênero na literatura em três séculos diferentes: século XIX, representada pelo conto “A Caolha” de Júlia Lopes de Almeida, século XX por meio do conto “Boa noite, Maria” de Lygia Fagundes Telles e o século XXI, através do conto “Aos sessenta e quatro” de Cíntia Moscovich. Investigaremos de que maneira as autoras redimensionam a representação feminina e propõem novas visões em relação aos estereótipos legitimados ao longo dos anos. Além disso, investigaremos como se (re)desenharam as mudanças discursivas na voz autoral da mulher antes, durante e após os movimentos sociais e culturais que marcaram a busca pela igualdade de direitos e as mudanças advindas com a industrialização, mudanças nas relações de consumo e de trabalho e as formas de exploração e dominação e resistência do mundo pós-moderno. Como fundamentação teórica serão apresentadas as contribuições de Zolin (2006), Duarte (2005), Lauretis (1994), Holanda (2003), Giddens (2002), Hall (2005) entre outros.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

14

Costa, Uisllei. „Cartografia de Línguas Indígenas do Amapá: levantamento preliminar das fontes de estudo e pesquisa“. Revista Brasileira de Línguas Indígenas 1, Nr. 2 (04.06.2020): 72. http://dx.doi.org/10.18468/rbli.2018v1n2.p72-81.

Der volle Inhalt der Quelle

Annotation:

O conceito de cartografia tem evoluído nas últimas décadas e corresponde a um conjunto de operações e estudos científicos que podem ser representados por mapas (Associação Cartográfica Internacional, 1966), contudo a cartografia pode ser utilizada nas mais diversas áreas. Nessa pesquisa, utiliza-se desse conceito para fazer referência a um conjunto de estudos existentes em uma determinada área: a Linguística. Assim sendo, o escopo deste estudo é de reunir referências e bibliografias sobre línguas indígenas do Estado do Amapá produzidas, preferencialmente, no último século e, excepcionalmente, no início da década do século XXI, a fim de e posteriormente, disponibilizá-las online. Nota-se que a dispersão dos materiais sobre línguas indígenas faladas ou consideradas extintas no Amapá são em primeira instância um limitador às pesquisas relativas a esse tema na região. Este trabalho é de caráter documental e se dá por meio de visitas técnicas a instituições, coleta de dados por meio de sites e nos principais bancos de informações. A partir desses dados, foi possível reunir mais de 120 referências, de diversas áreas e autores. Das produções coletadas há nomes já conhecidos dos estudiosos de línguas indígenas, tais como, Arnaud (1969, 1970, 1975,1980), Nimuendajú (1926), Gallois e Grupioni (2003), Gallois (1986, 1988, 1994, 2001, 2002, 2005), Green (1977, 1994, 1979) Grenand (1977, 1980, 1987, 1988, 1992, 1998), Vidal (1996, 2000, 2001), e outros. Por fim, compreendemos que esta pesquisa não é um construto completo e definitivo. E por esse motivo, apresenta fragilidades acerca de sua constante construção, porém, se apresenta como uma iniciativa inovadora para as pesquisas sobre línguas indígenas do Estado do Amapá.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

15

El Hallof, Nóra, und Mihály Sárvári. „Productivity and Nutrient Reaction of Maize Hybrids“. Acta Agraria Debreceniensis, Nr. 16 (06.12.2005): 78–83. http://dx.doi.org/10.34101/actaagrar/16/3293.

Der volle Inhalt der Quelle

Annotation:

Several factors influence the quantity and stability of maize yield, the most important being the nutrient supply, the hybrid and precipitation. In 2004, during the maize growing season the precipitation was more than the 30 year’s average, with 68.3 mm, but the distribution was unfavorable. The experiment was carried out in Debrecen at the Experimental Station of the University of Debrecen Centre of Agricultural Sciences, Department of Crop Production and Applied Ecology. We tested 10 various hybrids with their own genetic characteristics for five different fertilizer doses, in addition to the parcels without fertilization.The favorable results reached were due to the rainy season. The average yield varied between 7.78-9.67 tha-1. The DK 440, PR37M34, PR38A24, PR39D81 and PR36R10 of the hybrids reacted to higher fertilizer doses with significant growth yields, the yield (more than 11 tha-1) was the highest for N200, P125, K150 fertilizing. The other hybrids, DKC 5211, Mv Vilma and MV Maraton, gave similar results at the N120+PK fertilizer dose and the ensuing doses depressed the yield. Fertilization was more effective thanks to the precipitation. The fourth and fifth dose increased or decreased maize yield depending on the nutrient reaction of the hybrid. The agro-ecological optimum of NPK fertilization was N120, P75, K90 kgha-1.During the experiment we tested the moisture loss of five hybrids. The rainy crop year’s effect on the seed moisture content at harvest was higher than in previous years. The seed moisture content hybrids at harvest which have shorter crop years (FAO 300) was 18-19%, and hybrids with longer vegetation periods had more than 20% seed moisture content. DK 440 hybrid had the intensive moisture loss of the five hybrids, at the start of the measurement, the seed moisture content was higher than 40%, and it decreased to 18.6% by harvesting.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

16

Moreira dos Santos, Rubenita Alves. „ANÁLISE DE DON QUIJOTE, UMA ADAPTAÇÃO TEATRAL DE DON QUIJOTE DE LA MANCHA“. Letras Escreve 7, Nr. 3 (22.05.2018): 35. http://dx.doi.org/10.18468/letras.2017v7n3.p35-59.

Der volle Inhalt der Quelle

Annotation:

Este artigo analisa a adaptação teatral intitulada Don Quijote, baseada em uma obra clássica da literatura espanhola, El Ingenioso Hidalgo Don Quijote de la Mancha – Partes I (1605) e II (1615), de Miguel de Cervantes. Como uma adaptação envolve dois sistemas semióticos — o literário e o teatral — e visando à comprovação de que adaptação teatral e tradução intersemiótica se equivalem, faz-se necessário apresentar alguns estudos relacionados a: a) adaptação e b) tradução intersemiótica dos textos dramáticos. Dentre os autores que veem a adaptação numa perspectiva interartística, serão evidenciados os estudos de Silva e Gomes M. (2009), Dias (2007) e Diniz (2005). Alguns autores buscam fazer uma comparação entre adaptação e tradução, entre o trabalho desenvolvido pelos adaptadores e o trabalho desenvolvido pelos tradutores. Neste sentido, alguns veem a adaptação como tradução; outros, não. Assim, serão apresentadas essas duas vertentes, através de estudos de autores como Amorim (2003) e Torres (2003), entre outros. Observando-se uma interface entre os autores que se dedicam às traduções intersemiótica e literária e os que estudam a semiologia no texto teatral, serão comentadas as contribuições de Peirce (1974, apud Plaza, 2001), Plaza (2001), Jakobson (1973), Bassnett (2003), Ubersfeld (1978, apud Bassnett, 2003),Tordera Sáez (1999), Fernández (1981), Giulli Pugliatti (1976, apud Fernández, 1981), O. Zich (apud Fernández, 1981) e Kowzan (1977). No tópico “Tradução intersemiótica / adaptação teatral Don Quijote” serão discutidos os procedimentos da adaptação, relacionando-os aos assuntos desenvolvidos pelos teóricos estudados em tópicos anteriores. Palavras-chave: Don Quijote. Adaptação. Tradução intersemiótica.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

17

Henjum, Sigrun, Ingrid Barikmo, Anne Karine Gjerlaug, Abderraháman Mohamed-Lehabib, Arne Oshaug, Tor Arne Strand und Liv Elin Torheim. „Endemic goitre and excessive iodine in urine and drinking water among Saharawi refugee children“. Public Health Nutrition 13, Nr. 9 (01.04.2010): 1472–77. http://dx.doi.org/10.1017/s1368980010000650.

Der volle Inhalt der Quelle

Annotation:

AbstractObjectiveTo assess the prevalence of enlarged thyroid volume (Tvol) in Saharawi refugee children, and their urinary iodine concentration (UIC), and to identify possible sources of excess iodine intake.DesignA cross-sectional survey was performed during January–February 2007. Tvol was measured by ultrasound and iodine concentration was analysed in casual urine samples, in household drinking water and in milk samples from household livestock.SettingThe study was undertaken in four refugee camps in the Algerian desert.SubjectsThe subjects were 421 Saharawi children, 6–14 years old.ResultsEnlarged Tvol was found in 56 % (Tvol-for-age) and 86 % (Tvol-for-body-surface-area) of the children. The median (25th percentile–75th percentile, P25–P75) UIC was 565 (357–887) μg/l. The median (P25–P75) iodine concentration in household drinking water was 108 (77–297) μg/l. None of the children had UIC below 100 μg/l, 16 % had UIC between 100 and 299 μg/l, and 84 % had UIC above 300 μg/l. There was a positive association between Tvol and whether the household possessed livestock.ConclusionsThe children are suffering from endemic goitre and high UIC caused probably by an excessive intake of iodine. The excessive iodine intakes probably originate from drinking water and milk.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

18

Herman, M. „Sebelas Tahun Perkembangan Jagung Bt dan Statusnya secara Global“. Jurnal AgroBiogen 3, Nr. 2 (09.08.2016): 73. http://dx.doi.org/10.21082/jbio.v3n2.2007.p73-79.

Der volle Inhalt der Quelle

Annotation:

Major insect pests of corn are the Asian corn borer, the European corn borer, and the corn root worm. The value of crop losses due to the insect pests in America is $2.6 billion, Asia $1.6 billion, Africa $0.8 billion, and Europe $0.6 billion. Prior to the use of Bt corn, farmers used a lot of insecticides to control the insect pests. Following introduction of the Bt corn in 1996, this crop has been grown over 21 million hectares by millions of farmers from 13 countries in North America, Latin America, Asia, Africa and Europe. Globally, the farmers had been benefited by grownt the Bt corn. The benefits varies, dependent on countries and level of the corn borer infestations. In 2001, the US farmers gained $125 million benefit from growing the crop. In 2002, farmers in Spain gained 11-15 million benefit from the Bt corn alone. During the period of 2003-2005, corn farmers in the Philippines gained $8 million from the Bt corn. Bt corn has not been grown commercially in Indonesia, although Bt corn MON810 has been declared as save to release in the environment by the Indonesian Biosafety Committee. In 2001-2002, farmers in South Sulawesi with had grown Bt cotton, this was the first time Bt crop in the country since the placement and implementation of the biosafety regulation by the Indonesian Government in 1998.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

19

Paniz, Clovis, Maylla Rodrigues Lucena, Juliano Felix Bertinato, Patricia Mendonça da Silva Amorim, Guilherme Wataru Gomes, Maria Stella Figueiredo, Ralph Green et al. „Elevated Serum Folic Acid Concentrations Were Associated with Higher mRNA Expression of DHFR Gene in Patients with Hereditary Spherocytosis“. Blood 124, Nr. 21 (06.12.2014): 4005. http://dx.doi.org/10.1182/blood.v124.21.4005.4005.

Der volle Inhalt der Quelle

Annotation:

Abstract Background Folic acid (FA) is the synthetic form of folate, a B complex vitamin which plays an important role in several reactions in the body. Folate deficiency produces several clinical complications including anemia and is associated with an increased risk of cancer, cardiovascular disease and neural tube defects. With the advent of FA and iron fortification of wheat and corn flour (150 µg of folic acid and 4.2 mg of iron/100 grams) in Brazil since 2004, the population was exposed to amounts of folate beyond that normally present in foods. The form present in fortified food is taken up by cells and reduced by the enzyme dihydrofolate reductase (DHFR) first to dihydrofolate (DHF) and then tetrahydrofolate (THF). DHF is the preferred natural substrate. Amounts of FA higher than the defined tolerable upper intake of 1 mg/day could impair the ability of DHFR to convert DHF to THF. Some patients with hemolytic anemia, such as hereditary spherocytosis (HS), need larger amounts of FA to compensate for their increase in erythropoiesis and have been receiving 5mg/day of supplemental FA, the only formulation available in Brazil, in addition to being exposed to compulsory food fortification with FA. Objective The aim of this study was to compare the effects of 5mg/day FA on serum folate levels, mRNA expression of DHFR, MTHFR, interferon-γ, TNF-α and interleukin-8 genes; and cytotoxicity of lymphocytes and NK cells in patients with HS and healthy individuals not receiving supplemental FA. Material and Methods Twenty-five patients with HS exposed to mandatory fortification and in use or not of 5 mg/day of FA were included in this study. Forty-five healthy people were recruited as a control group, and matched with HS patients according to age, gender, body mass index and self-reported skin color. Blood count, including reticulocytes, C-reative protein and lactic dehydrogenase (LDH) were performed. Serum folate (SF) and vitamin B12 were determined by a microbiological method. The mRNA expression of DHFR, MTHFR, interferon-γ, TNF-α and interleukin-8 genes in mononuclear cells were performed in duplicate, using Real Time PCR. Cytotoxicity of lymphocytes and NK cells were also carried out using a flow cytometric assay. Results Eight HS patients did not use FA 5 mg everyday (4 declared no use anytime and 4 reported intermittent use) and none of control group used FA supplementation. Reticulocytes and LDH were higher in HS group (P<0.05), however no difference was found between levels of C-reative protein (P=0.173) and vitamin B12 (P= 0.699) when compared with control group. The HS group had higher SF levels and elevated mRNA expression of DHFR, MTHFR, interferon-γ, TNF-α and interleukin-8 when compared with controls (P<0.05, Figure 1). It is not clear whether FA use or underlying disease was be responsible for increasing of mRNA expression of these genes. To verify the effect of SF levels on HS patients, this group was classified into two subgroups according to median SF (< 46.6 and ≥ 46.6 nmol/L). Interestingly, the subgroup with higher SF levels showed significantly elevated DHFR mRNA expression but no difference was found in the mRNA expression of the other genes studied. The two subgroups were similar according to WBC, RBC, hemoglobin, MCV, reticulocytes, LDH, C-reative protein, vitamin B12 and cytotoxic capacity of lymphocytes and NK cells. Conclusions Elevated SF concentrations were associated with higher mRNA expression of DHFR gene in HS patients, suggesting that the use of higher amounts of FA might influence the expression and activity of DHFR and thus affect folate metabolism in these patients. It is not known whether normal subjects receiving similar high doses of FA show the same effects. Financing: FAPESP 2012/12912-1 and CNPq 4826412012-6 Figure 1 – Serum folate levels (A) and DHFR mRNA (B) in hereditary spherocytosis and control group. The DHFR mRNA expressions in HS patients according to serum folate levels were shown (C). Figure 1 – Serum folate levels (A) and DHFR mRNA (B) in hereditary spherocytosis and control group. The DHFR mRNA expressions in HS patients according to serum folate levels were shown (C). The line in each graphic is the median. The median and percentiles 25 and 75 (P25 – P75) for control and hereditary spherocytosis groups were, respectively: A- serum folate: 22.1 (14.5 – 36.6 nmolL) and 51.5 (19.5 – 95.2 nmolL), B- DHFR mRNA expression: 1.59 (1.00 – 2.48) and 35.8 (19.0 – 52.7). In Figure C, the median and percentiles 25 and 75 (P25 – P75) for DHFR mRNA expression, according to serum folate levels (SF <46.6 and SF ≥ 46.6 nmol/L), were, respectively: 19.6 (1.4 – 38.6) and 50.3 (23 – 66.8). Disclosures No relevant conflicts of interest to declare.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

20

Gorgun, Gullu, und Francine Foss. „Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox“. Blood 100, Nr. 4 (15.08.2002): 1399–403. http://dx.doi.org/10.1182/blood-2002-01-0300.

Der volle Inhalt der Quelle

Annotation:

Rexinoids binding to both the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families of rexinoid receptors have demonstrated clinical activity in hematologic malignancies and have been shown to mediate genes associated with both growth and differentiation. RXR rexinoids have demonstrated efficacy in the treatment of cutaneous T-cell lymphomas, but the mechanism of action is unclear. We explored the immunomodulatory effects of RAR and RXR rexinoids in human T- and B-cell leukemia cells and demonstrated that RXR rexinoids are capable of up-regulating high-affinity interleukin-2 receptor (IL-2R) expression. Exposure to 10−6 to 10−10 M bexarotene or Panretin for 48 hours was associated with increased expression of both the p55 and p75 subunits of the IL-2R in T-cell leukemias and p75 in B-cell leukemias. Furthermore, rexinoid exposure enhanced susceptibility of the cells to denileukin diftitox fusion toxin-targeting and -intoxicating cells expressing high-affinity IL-2R. These results suggest a rationale for combining rexinoids with IL-2R–targeted therapies in lymphoid malignancies as well as possibly in autoimmune diseases.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

21

SOARES, Luiz Henrique Moreira, und Rosiney Aparecida Lopes do VALE. „ELA É AMAPÔ DE CARNE, OSSO E PALAVRAS: PERSONAGENS TRAVESTIS NO ROMANCE CONTEMPORÂNEO BRASILEIRO“. Revista do Instituto de Políticas Públicas de Marília 3, Nr. 1 (24.10.2017): 79–96. http://dx.doi.org/10.33027/2447-780x.2017.v3.n1.07.p79.

Der volle Inhalt der Quelle

Annotation:

Nas palavras de Candido (2006), a literatura é um espaço onde há a possibilidade de expressar e problematizar as dinâmicas sociais. Longe da neutralidade discursiva, a literatura pode agir tanto na confirmação de consensos, quanto produzir novos sentidos para a realidade, construir rupturas. A produção literária contemporânea, embora se apresente difusa e homogênea, com novas formas de construção narrativa e novos atores sociais, que configuram o centro e as margens, encontra dificuldade na configuração dos sujeitos que fogem das normas de gênero. Sendo assim, presente artigo propôs a mapear, investigar e analisar as configurações de violência e subalternidade de personagens travestis no romance brasileiro contemporâneo (2000-2016). Percebeu-se que o discurso literário, aliado ao discurso das mídias e outros meios culturais,atravessa os corpos das personagens travestis, de forma a inserir-lhes uma história única, que não representa um todo subjetivo e ambíguo, produto de nossa época. Para isso, o artigo apoiou-se nos estudos de Judith Butler (2003), Don Kulick (2008), Regina Dalcastagnè (2012), Beatriz Resende (2008) e outros(as) teóricos(as) que foram utilizados(as) no decorrer da pesquisa.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

22

Johnson, R. C., Li Dajue und Vicki Bradley. „Autumn growth and its relationship to winter survival in diverse safflower germplasm“. Canadian Journal of Plant Science 86, Nr. 3 (07.07.2006): 701–9. http://dx.doi.org/10.4141/p05-104.

Der volle Inhalt der Quelle

Annotation:

The relationship between several autumn growth traits and winter survival was determinedin 11 diverse safflower (Carthamus tinctorius L.) accessions grown at Central Ferry and Pullman, WA, USA. The safflower was sown in September 2002 and 2003 and plant population counts were taken 6-8 wk after emergence, and after the last frost in the spring to calculate winter survival. Growth factors including plant habit and height were also measured in the autumn. The Pullman plots in 2003–2004 were lost during an usually cold and windy November, but otherwise survival ranged from 90% for BJ-27, an introduction from China, to zero for the cultivar Saffire. Winter survival was negatively correlated with more upright plant habit (r = -041**, n = 97) and plant height (r = -0.29**, n = 97). However, some accessions with low plant habit (prostrate growth) and low height values had relatively poor survival. The results show that BJ-27 has sufficient winter survival to achieve over-winter safflower production for many areas. Autumn plant habit and height can predict the potential for winter survival, but physiological factors related to cold acclimation appeared to determine if that potential is realized. Key words: Carthamus tinctorius, safflower, winter hardiness, cold tolerance

APA, Harvard, Vancouver, ISO und andere Zitierweisen

23

Roman-Gomez, Jose, Antonio Jimenez-Velasco, Juan A. Castillejo, Xabier Agirre, Manuel Barrios, German Navarro, Francisco J. Molina et al. „Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia“. Blood 104, Nr. 8 (15.10.2004): 2492–98. http://dx.doi.org/10.1182/blood-2004-03-0954.

Der volle Inhalt der Quelle

Annotation:

Abstract Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). To determine the extent of hypermethylation in ALL, we analyzed the methylation status of the CDH1, p73, p16, p15, p57, NES-1, DKK-3, CDH13, p14, TMS-1, APAF-1, DAPK, PARKIN, LATS-1, and PTEN genes in 251 consecutive ALL patients. A total of 77.3% of samples had at least 1 gene methylated, whereas 35.9% of cases had 4 or more genes methylated. Clinical features and complete remission rate did not differ among patients without methylated genes, patients with 1 to 3 methylated genes (methylated group A), or patients with more than 3 methylated genes (methylated group B). Estimated disease-free survival (DFS) and overall survival (OS) at 11 years were 75.5% and 66.1%, respectively, for the nonmethylated group; 37.2% and 45.5% for methylated group A; and 9.4% and 7.8% for methylated group B (P < .0001 and P = .0004, respectively). Multivariate analysis demonstrated that the methylation profile was an independent prognostic factor in predicting DFS (P < .0001) and OS (P = .003). Our results suggest that the methylation profile may be a potential new biomarker of risk prediction in ALL.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

24

Chen, C. J., Y. C. Huang, L. H. Su und T. Y. Lin. „P751 Epidemiology of invasive Streptococcus pneumoniae in Taiwan, 2001–2003“. International Journal of Antimicrobial Agents 29 (März 2007): S185. http://dx.doi.org/10.1016/s0924-8579(07)70592-7.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

25

Roy, R. C., B. R. Ball Coelho, A. J. Bruin, R. Reeleder und B. Capell. „Scheduling drip irrigation for ginseng (Panax quinquefolius L.) grown under straw and bark mulch“. Canadian Journal of Plant Science 87, Nr. 2 (01.04.2007): 373–81. http://dx.doi.org/10.4141/p05-228.

Der volle Inhalt der Quelle

Annotation:

Responses of ginseng to drip irrigation regimes and organic mulches were determined in two experiments beginning in 1998 and 1999. Treatments were four soil water content thresholds for irrigation: 0, 0.08, 0.12 and 0.16 m3 m-3 (θ0, θ8, θ12, and θ16, respectively); combined with either straw or bark mulch. In its first growing season, ginseng did not require irrigation in 1999 or 2000. In subsequent years, irrigation was generally more frequent when applied at higher moisture threshold levels, but precipitation affected irrigation frequency under all treatments. Water use increased with crop age to 3yr, to about 65% of the requirement of unshaded horticultural crops. Seed yield from 3-yr-old plants under straw mulch in 2001 was greater in response to θ12 and θ16 than to θ8 or θ0. Root yield response to irrigation threshold was linear for 2- and 3-yr- old plants under straw mulch in 2001, and quadratic for 3-yr-old plants under bark mulch in 2002. The optimal threshold to initiate drip irrigation was approximately 65% of field capacity. Key words: Root, soil water, water use

APA, Harvard, Vancouver, ISO und andere Zitierweisen

26

Sanchez, H., N. Campoverde und P. Sanchez. „P675 Breast cancer incidence, according to data from Ecuadorian tumor records (2000-2004)“. International Journal of Gynecology & Obstetrics 107 (Oktober 2009): S606—S607. http://dx.doi.org/10.1016/s0020-7292(09)62166-4.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

27

Azpiri-López, J. R., I. J. Colunga-Pedraza, D. Á. Galarza-Delgado, V. M. Beltran-Aguilar, V. Gonzalez-Gonzalez, A. G. Arias Peralta, N. De Avila Gonzalez, J. A. Cardenas-de la Garza und G. García-Arellano. „AB0240 RHEUMATOID ARTHRITIS CLINICAL ACTIVITY IS NOT ASSOCIATED TO CARDIOVASCULAR RISK AS MEASURED BY TRADITIONAL RISK SCALES“. Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 1304.2–1305. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3099.

Der volle Inhalt der Quelle

Annotation:

BackgroundRheumatoid arthritis (RA) patients have a higher cardiovascular risk (CVR) than the general population, being atherosclerotic cardiovascular disease the main cause of mortality [1]. Such increased could be explained by traditional CVR factors and chronic inflammatory state of disease. Clinical activity of disease, which is evaluated by DAS-28, is a parameter that denotes the current inflammatory status. [2]ObjectivesTo compare CVR, by six scales: ACC/AHA ASCVD 2013, Framingham lipids and BMI, SCORE2, QRISK3 and Reynolds risk score, according to clinical activity of RA patients using DAS-28 CRP.MethodsDescriptive, comparative and cross-sectional study. We enrolled RA patients between 40 and 75 years old who fulfilled ACR/EULAR 2010 classification criteria and recruited in the Rheumatology service from a tertiary care hospital, in Monterrey, Mexico. Patients were divided by time of disease evolution into quartiles. CVR results from scales were multiplied by 1.5 factor according to EULAR 2016 recommendation. Normality was assesed by Kolmogorov-Smirnov test. Variables with a non-normal distribution were described by median and interquartile range (p25-p75). Differences between groups was analyzed by Kruskal-Wallis test or Chi-squared, accordingly.ResultsA total of 377 RA patients were included. Demographic characteristic are shown in Table 1. An increased in acute phase reactants, CRP (p= 0.000) and ESR (p= 0.003) was found, as severity of clinical activity increased, meanwhile CVR did not show significative changes, regardless of which of scales it was measured by.ConclusionCVR did not increase according to clinical activity of RA, which suggests that such severity can not explain by itself the increased in risk showed in this population.References[1] England BR, Thiele GM, Anderson DR, Mikuls TR. Increased cardiovascular risk in rheumatoid arthritis: Mechanisms and implications. BMJ (Online). 2018;361.[2] Solomon DH, Reed GW, Kremer JM, Curtis JR, Farkouh ME, Harrold LR, et al. Disease Activity in Rheumatoid Arthritis and the Risk of Cardiovascular Events. Arthritis & Rheumatology. 2015 Jun;67(6):1449–55.Table 1.Demographic characteristics (n= 377)VariableRemisión(n= 121)Low activity (n=51)Moderate activity (n=156)High activity (n=49)pDuration of disease, years. median (p25-p75)7.0 (3.0-14.0)7.9 (2.7-14.9)7.0 (3.0-15.4)5.1 (1.6-12.9)NSWomen, (n)%103 (85)47 (92)149 (95)49 (100)0.002Age, years. median (p25-p75)57 (49-62)53 (48-63)54 (48-59)55 (45-58)NSBMI, kg/m2. median (p25-p75)27.2 (25.0-30.4)26.7 (24.7-30.8)28.0 (24.6-31.8)28.4 (24.7-32.3)NSLaboratory tests, median (p25-p75)CPR, mg/dL.0.5 (0.2-0.9)0.7 (0.3-1.4)0.9 (0.4-1.6)1.2 (0.6-2.9)0.000ESR, mm/H.22.0 (15.0-32.5)23.0 (16.0-41.0)28.0 (18.0-42.0)30.0 (18.0-56.0)0.003ACPA, U/mL.99.8 (2.6-199.1)23.2 (1.4-195.5)44.9 (1.1-198.7)7.6 (1.2-191.3)NSRF IgG, U/mL.4.3 (2.0-12.2)4.6 (2.0-11.5)4.8 (2.0-16.0)3.2 (2.0-9.9)NSRF IgM, U/mL.200.0 (38.0-200.0)200.0 (35.4-200.0)200.0 (56.7-200.0)160.1 (20.4-200.0)NSRF IgA, U/mL.75.6 (11.3-200.0)68.8 (7.0-200.0)47.4 (6.6-197.1)68.1 (2.8-200.0)NSCardiovascular risk scores, %. medianASCVD4.82.82.63.1NSFRS-Lipids8.87.67.37.8NSFRS-BMI12.511.19.311.1NSSCORE 264.54.54.5NSQ-RISK III6.15.34.55.7NSRRS1.51.51.51.5NSThis table shows demographic and clinical characteristics. BMI Body Mass Index; CRP C Reactive Protein; ESR Erythrocyte Sedimentation Rate; ACPA Anti–Citrullinated Protein Antibody; RF Rheumatoid Factor; ASCVD Atheroesclerotic Cardiovascular Disease; FRS Framingham Risk Score; RRS Reynolds Risk Score; SCORE 2 Systematic Coronary Risk Evaluation 2.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

28

Besana, Angela, und Annamaria Esposito. „Memory, Marketing and Economic Performances in Usa Symphony Orchestras and Opera Houses“. European Journal of Economics and Business Studies 9, Nr. 1 (06.10.2017): 79. http://dx.doi.org/10.26417/ejes.v9i1.p79-89.

Der volle Inhalt der Quelle

Annotation:

When resources are scarce at crisis times and when competition is intense with other creative supplies, USA symphony orchestras and opera houses memorize and perform their repertoires (or repertories), so that seasons are crucially bundled between tradition and innovation. Since the beginning of the latest financial and real crisis (2007), USA classical music has seen different levels of funding from the federal government and businesses have encouraged more nonconventional programming (Pompe, Tamburri, 2016; Turbide, Laurin, 2009; Ravanas, 2008; Rushton, 2008; Turrini, 2006; Smith, 2007). On one side, fundraisers have stressed bundles (contemporary music with tradition) to sponsors; on the other side, marketing officers have emphasized the repertoire memory to audiences who constantly love Traviata, Boheme and Don Giovanni with echo of famous regisseurs, scenographers, etc. This is quite the same worldwide (Cancellieri, Turini, 2016). Fundraising and marketing affect economic performances of classical music, also thanks to social media and networks. Consumers have access to information about ticketing, rehearsals, present and past performances, etc. Art organizations strive to manage communication via social media to create brand values. Social media support both fundraising and marketing, as they mediate to sponsors and audiences: values, advocacy, videos and photos of the repertoire and nonconventional programming, which continually increase trustworthy relationships and nurture memories.This paper investigates 200 USA symphony orchestras and opera houses according to repertoires, revenues, expenses and gains in 2008 and 2015. With cluster analysis, three profiles emerge with different strategies, performances and emphasis on memory or innovation.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

29

Hanlan, T. G., R. A. Ball und A. Vandenberg. „Canopy growth and biomass partitioning to yield in short-season lentil“. Canadian Journal of Plant Science 86, Nr. 1 (01.01.2006): 109–19. http://dx.doi.org/10.4141/p05-029.

Der volle Inhalt der Quelle

Annotation:

Lentil (Lens culinaris L.) cultivars in the large green market class in Western Canada have late-season bushy growth, low harvest index (HI), and lodge readily. The aim of this study was to compare a range of genotypes for canopy traits such as rapid growth, light interception, HI, lodging, and yield. Four stiff-stem unadapted genotypes varying in leaf size and canopy openness were compared with two large green market class and other locally adapted cultivars at three population densities in the field in 2001 and 2002. Canopy measurements included biomass and light interception at weekly intervals, lodging score, end of season HI and yield. Adapted cultivars had high biomass (525 to 700 g m-2), high seed yield (96 to 130 g m-2), high maximum light interception (61 to 80%), high final branch number (17 to 19), and greatest overall plant height (0.3 to 0.44 m), but large green cultivars were prone to lodging. Unadapted genotypes produced less biomass and lodged the least. Genotypes that accumulated most above-ground biomass yielded the highest, grew the tallest, branched the most, but lodged the most. Unadapted genotypes FLIP 2000-7L (tallest, highest yielding of the unadapted types) and FLIP 96-7L (most lodging resistant (2001) and most brittle stemmed (2002) were promising parents for improving lodging resistance, on the basis of lodging resistance and yield or stem stiffness, respectively. CDC Milestone had the best canopy characteristics of moderate biomass and high harvest index for Western Canada. Key words: Lentil, Lens culinaris, biomass, harvest index, yield, lodging

APA, Harvard, Vancouver, ISO und andere Zitierweisen

30

Altay, Asc Prof Dr İclal Kaya, und Shqiprim Ahmeti. „Evaluation of EU Cohesion Policies within the scope of Lisbon and Europe 2020 Strategies“. European Journal of Social Sciences Education and Research 10, Nr. 2 (19.05.2017): 79. http://dx.doi.org/10.26417/ejser.v10i2.p79-93.

Der volle Inhalt der Quelle

Annotation:

In order to increase the level of integration and development at the scale of the Union and to raise the conditions of competition on a global scale, EU has announced two basic development strategies within the process: Lisbon Strategy (2000) and the Europe 2020 Strategy (2010). Though the EU 2000-2006 Cohesion Policies corresponding to the 2000-2006 fiscal period and 2007-2013 Cohesion Policy Program that was reformed in comparison to the previous program were prepared within the scope of the Lisbon Strategy, 2014-2020 financial program and Cohesion Policies have been produced within the context of EUROPE 2020 Strategy. During the said process, the objectives and priorities as well as the budgets of the EU structural funds have changed. In March 2000, the European Council meeting in Lisbon set the strategic goal of transforming the EU into ‘the most competitive and dynamic knowledge-based economy in the world’ within a decade. Among the jointly agreed goals to be attained by 2010 were raising investment in research and development to three per cent of gross domestic product (GDP) and increasing the rate of employment within the EU from 61 to 70 per cent of the working-age population (Teasdale, 2012). Based on the interim evaluations of Lisbon Strategy, EU Commission stated that the required specific objectives could not be achieved because the financial crisis and planned reforms could not be implemented. At the same time, the major expansion in 2004 made the existing inter-regional disparities more evident. Published on 2010 by EC, Europe 2020 Strategy (which is considered to be a reviewed and updated Lisbon Strategy) brought in a new expansion in terms of achieving the initial objectives. The strategy in question focuses not only on the economic – social cohesion but also on spatial cohesion. However, the statistics within the process reveal that the economic, social and territorial cohesion could not be achieved at the scale of EU yet, even it has been asserted in a report, which was prepared by the Secretariat of the Conference of Peripheral Maritime Regions (CPMR) in 2015 that besides the disparities between the Member States, disparities between regions within countries increased, as well. Within the scope of this study, it will be discussed how much the cohesion target, given in the founding treaty of EU is reflected on the development strategies; the role and accomplishments of these strategies and funds in achieving that target. While the role and accomplishments of the Europe 2020 Strategy, which is still in effect today, are questioned in terms of ensuring particularly the territorial cohesion, also the importance and the priority granted to urban spaces in order to achieve the objectives of strategies - as well as objectives of the founding agreement – will be discussed. The Method of the Study can be summarized as the literature survey based on the Lisbon and Europe 2020 Strategies of European Commission, the EU Financial Period Programs and observations and critics prepared by a variety of institutions as well as the evaluation of the findings based on statistical datas.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

31

Ci, W., J. Zhao, Y. Wang, L. Pan und M. Li. „POS0724 RISK FACTORS FOR CORONARY ARTERY DISEASE IN CHINESE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A MULTI-CENTER, RETROSPECTIVE, COHORT STUDY“. Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 644.3–645. http://dx.doi.org/10.1136/annrheumdis-2022-eular.51.

Der volle Inhalt der Quelle

Annotation:

BackgroundCoronary artery disease (CAD) not only has an increased prevalence but also is a major cause of premature mortality in systemic lupus erythematosus (SLE) [1, 2]. However, information is limited regarding the risk factors for CAD in Chinese patients with SLE.ObjectivesTo assess the risk factors for CAD in Chinese patients with SLE.MethodsThis multi-center, retrospective, cohort study included 3778 consecutive SLE patients, with CAD (CAD group) or without a medical history of CAD (control group). CAD was defined as a coronary stenosis ≥50% in any major epicardial coronary vessel detected by coronary angiography or a history of myocardial infarction confirmed by medical records. General parameters, clinical features, laboratory tests and medical therapies were compared between groups, and the risk factors for CAD in SLE were analyzed by logistic regression analysis.ResultsThe age at baseline was older, male ratio was higher and body mass index was greater in CAD group (all P<0.001). Traditional CAD risk factors including diabetes mellitus, hypertension, dyslipidemia, family history of CAD and smoking were more common in CAD group (all P<0.001) (Figure 1). SLE Disease Activity Index 2000 was greater (P=0.012), hyperuricemia and elevated C-reactive protein (CRP) were more prevalent (both P<0.001), and an increased corticosteroids’ usage (P=0.018) was detected in CAD group (Table 1). Binary logistic regression analysis showed hyperuricemia (odds ratio: 3.082, 95% confidence interval: 1.283-7.403; P=0.012) and CRP (odds ratio: 7.248, 95% confidence interval: 2.931-17.925; P<0.001) were independent risk factors for CAD in SLE patients.Table 1.Comparison of clinical features in SLE patients between CAD group and control group.ParametersControl group (n=3732)CAD group (n=46)PAge at baseline [years, median (P25, P75)]35.00 (29.00, 45.00)59.50 (50.25, 67.75)<0.001Male, n (%)296 (7.94)11 (23.91)<0.001Disease duration [years, median (P25, P75)]8.00 (4.00, 12.00)10.00 (4.00, 19.00)0.173Body mass index [kg/m2, median (P25, P75)]21.77 (19.63, 24.16)23.50 (22.09, 25.36)<0.001Renal disorder, n (%)1737 (46.57)9 (19.57)<0.001Neurologic disorder, n (%)595 (15.95)3 (6.52)0.082Thrombocytopenia, n (%)859 (23.03)8 (17.39)0.366SLEDAI-2K [median (P25, P75)]3.00 (0.00, 8.00)5.50 (1.50, 14.00)0.012Elevated creatinine, n (%)295 (7.91)10 (21.74)0.002Hyperuricemia, n (%)209 (5.60)16 (34.78)<0.001Elevated ESR, n (%)951 (25.5)22 (47.83)0.001Elevated CRP, n (%)210 (5.63)15 (32.61)<0.001Positive aPL, n (%)734 (19.68)11 (23.91)0.474Corticosteroids, n (%)2752 (73.78)41 (89.13)0.018Immunosuppressants, n (%)2950(79.09)37 (80.43)0.823Abbreviations: aPL, antiphospholipid antibody; CAD, coronary artery disease; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; SLE, systemic lupus erythematosus; SLEDAI-2K, SLE Disease Activity Index 2000. P <0.05 are shown as italics and bold.Figure 1.Comparison of traditional risk factors in SLE patients between CAD group and control group. Abbreviations: CAD, coronary artery disease; SLE, systemic lupus erythematosus. All P<0.001.ConclusionHyperuricemia and CRP are independent risk factors for CAD in SLE patients. This study highlights the association between hyperuricemia, CRP and CAD burden in SLE, and might provide a modifiable perspective on improving SLE outcomes.References[1]Gonzalez LA, Alarcon GS. The evolving concept of SLE comorbidities [J]. Expert Rev Clin Immunol, 2017, 13(8): 753-768.[2]Kostopoulou M, Nikolopoulos D, Parodis I, et al. Cardiovascular Disease in Systemic Lupus Erythematosus: Recent Data on Epidemiology, Risk Factors and Prevention [J]. Curr Vasc Pharmacol, 2020, 18(6): 549-565.Disclosure of InterestsNone declared

APA, Harvard, Vancouver, ISO und andere Zitierweisen

32

Yang, Hui, Tapan Kadia, Lianchun Xiao, Carlos E. Bueso-Ramos, Koyu Hoshino, Deborah Ann Thomas, Susan O'Brien et al. „Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome–negative acute lymphocytic leukemia“. Blood 113, Nr. 9 (26.02.2009): 1892–98. http://dx.doi.org/10.1182/blood-2008-02-141002.

Der volle Inhalt der Quelle

Annotation:

Pretreatment aberrant DNA methylation patterns are stable at time of relapse in acute lymphocytic leukemia (ALL). We hypothesized that the detection of residual methylation alterations at the time of morphologic remission may predict for worse prognosis. We developed a real-time bisulfite polymerase chain reaction assay and analyzed the methylation levels of p73, p15, and p57KIP2 at the time of initial remission in 199 patients with Philadelphia chromosome-negative and MLL− ALL. Residual p73 methylation was detected in 18 (9.5%) patients, p15 in 33 (17.4%), and p57KIP2 in 7 (3.7%); 140 (74%) patients had methylation of 0 genes and 48 (25%) of more than or equal to 1 gene. In 123 (65%) patients, matched pretreatment samples were also studied and compared with remission ones: in 82 of those with initial aberrant methylation of at least one gene, 59 (72%) had no detectable methylation at remission and 23 (28%) had detectable residual methylation. By multivariate analysis, the presence of residual p73 methylation was associated with a significant shorter duration of first complete remission (hazard ratio = 2.68, P = .003) and overall survival (hazard ratio = 2.69, P = .002). In conclusion, detection of epigenetic alterations allows the identification of patients with ALL with standard risk but with poor prognosis.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

33

Atu Dewi, A. A. Istri Ari. „KEWENANGAN PEMERINTAH DALAM PENGENDALIAN PENDUDUK PENDATANG DENGAN MELIBATKAN DESA PAKRAMAN“. Jurnal Magister Hukum Udayana (Udayana Master Law Journal) 5, Nr. 4 (31.05.2017): 871. http://dx.doi.org/10.24843/jmhu.2016.v05.i04.p15.

Der volle Inhalt der Quelle

Annotation:

Population has been a complex problem in development these days, especially in Denpasar, rapid population growth with limited support and capacity is the main problem. In conncetion to that, this research is aiming to find out 2 (two) things: first, to know juridical regulation for migrants in Denpasar. Second, to know about the involment of Pakraman Village (Customary Village) in managing migrants. This research uses statute approach. According to research it is concluded that: first, to anticipate rapid population growth or manage migrants in legal area of Denpasar, Government of Denpasar bases its authority in 1945 Constitution of the Repulic of Indonesia, Law Number 23 of 2014, Law Number 23 of 2006 as amended in Law Number 24 of 2013, Local Government of Bali Act Number 10 of 1998, Local Government of Bali Act Number 3 of 2001, Local Government Act Number 5 of 2014 concerning Amendement of Local Government Act of Denpasar Number 6 of 1996 concerning Framework Implementation for Population Registration in Population Management Information System, Mayor Act Number 593 of 2000 concerning Migrants Management. This act is also amended to Mayor Act Number 610 of 2002 concerning Amandement of Mayor Act Number 539 of 2000. Second, the involment of Pakraman village in managing migrants in Denpasar is regulated under the said Local Government Act, Mayor Act and Agreement between Government with Pakraman Village in Denpasar. The regulation is clear, giving the village authority to manage migrants in accordance to local customary law in force (awig-awig). This Research recommends that a clearer regulation in awig-awig and implementation of policies concerning migrants management is needed. Masalah kependudukan telah menjadi persoalan yang sangat kompleks dalam perkembangan dewasa ini, khususnya di Kota Denpasar, pertumbuhan penduduk sangat pesat dengan daya dukung serta daya tampung sangat terbatas menjadi persoalan utama. Berhubungan dengan hal tersebut maka dilakukan penelitian untuk mengetahui 2 (dua) hal yaitu : pertama, untuk mengetahui pengaturan secara yuridis penduduk pendatang di Kota Denpasar. Kedua, untuk mengetahui mengenai keterlibatan desa pakraman dalam pengendalian penduduk pendatang. Pendekatan yang digunakan adalah pendekatan peraturan perundang-undangan (statue approach). Berdasarkan hasil penelitian dapat disimpulkan sebagai berikut : pertama, untuk mengantisipasi ledakan kependudukan ataupun pengendalian penduduk pendatang di wilayah hukum Kota Denpasar, Pemerintah Kota Denpasar mendasarkan kewenangannya dengan UUD Negara Republik Indonesia Tahun 1945, UU 23 Tahun 2014, UU 23 Tahun 2006 sebagaimana telah diubah dengan UU Nomor 24 Tahun 2013, Perda Provinsi Bali 10 Tahun 1998, Perda Provinsi Bali 3 Tahun 2001, Perda 5 Tahun 2014 tentang Perubahan atas Peraturan Daerah Kota Denpasar Nomor 6 Tahun 1996 tentang Penyelenggaraan Pendaftaran Penduduk dalam Kerangka Sistem Informasi manajemen Kependudukan (SIMDUK), Keputusan Walikota Nomor 593 Taun 2000 tentang Penertiban Penduduk Pendatang. Keputusan ini juga terjadi perubahan yaitu Keputusan Walikota Denpasar Nomor 610 Tahun 2002 tentang Perubahan Keputusan Walikota Denpasar Nomor 539 Tahun 2000. Kedua, mengenai pelibatan Desa Pakraman dalam pengendalian penduduk pendatang di Kota Denpasar diatur secara jelas di dalam Perda, Keputusan Walikota dan Kesepakatan Kerja sama antara Pihak Kedinasan dengan Pihak Desa Pakraman di Kota Denpasar. Pengaturan secara jelas keterlibatan Desa Pakraman, memberikan otoritas kepada Desa Pakraman dalam pengendalian Penduduk pendatang sesuai dengan awig-awig desa pakraman setempat. Rekomendasi penelitian adalah perlu adanya pengaturan lebih jelas dalam awig-awig desa pakraman dan penerapan kebijakan-kebijakan hukum yang sungguh-sungguh terkait dengan pengendalian penduduk pendatang.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

34

Hägerström, Matilda Nifelt, Emma Rörby, Gillian May, Alex Tipping, John Brown, Göran Karlsson, Tariq Enver und Stefan Karlsson. „Gata2 Is a Direct Target for Smad-Mediated TGFβ Signaling in Hematopoietic Stem/Progenitor Cells“. Blood 118, Nr. 21 (18.11.2011): 1311. http://dx.doi.org/10.1182/blood.v118.21.1311.1311.

Der volle Inhalt der Quelle

Annotation:

Abstract Abstract 1311 Hematopoietic stem cells (HSCs) can give rise to all the different cells of the blood system, and at the same time maintain the stem cell pool throughout the lifetime of the organism. For clinical purposes it would be beneficial to expand the most primitive HSCs in culture without losing their potential. However, this demands increased knowledge regarding the factors that regulate HSC fate decisions, including self-renewal. Transforming growth factor-β (TGFβ) is a potent inhibitor of HSC proliferation in vitro (Batard et al. JCS, 2000; Keller et al. Blood, 1990; Sitnicka et al. Blood, 1996) and the TGFβ signaling pathway has been shown to be activated in HSCs in vivo (Yamazaki et al. Blood, 2009). Together with the observed loss of self-renewal in Smad4 KO HSCs (Karlsson et al. JEM, 2007), this suggests that TGFβ has a role in keeping the HSCs in a dormant state. The mechanisms underlying this effect is largely unknown, even though the cell cycle inhibitor p57 has been demonstrated to play an important role in TGFβ-induced cell cycle arrest of primary human hematopoietic cells (Scandura et al. PNAS, 2004). Murine long-term HSCs (lineage−, sca1+, ckit+ (LSK)CD34−) have been reported to express high levels of p57, while short-term HSCs (LSKCD34+) do not (Yamazaki et al. EMBO J, 2006). Here, we aim to further identify and functionally validate gene targets of TGFβ signaling in hematopoietic stem/progenitor cells (HS/PCs). In agreement with earlier studies, quantitative PCR (qPCR) analysis of freshly sorted murine HS/PCs revealed upregulation of p57 (2.8±1.2 fold, P=0.045) following TGFβ (10ng/ml) treatment of LSKCD34+ cells. However, p57 expression in LSKCD34− cells was unaffected by TGFβ-treatment. Additionally, TGFβ-induced upregulation of p57 was delayed (5h) and could be effectively diminished by cycloheximide treatment implying that p57 activation is a secondary response to TGFβ. To identify early targets of TGFβ signaling we therefore performed microarray analysis 2h following TGFβ-treatment of Lhx2 cells, a primitive murine hematopoietic cell line with in vivo multi-lineage reconstitution potential (Pinto et al. Blood, 2002) and generated a database of differentially expressed genes involved in HS/PC proliferation and potentially HSC quiescence. Interestingly, we observed upregulation of the transcription factor Gata2, previously described as an important regulator of HSC function (Rodrigues et al. Blood, 2005; Tipping et al. Blood, 2009). To validate this finding in primary cells we performed qPCR analysis on freshly sorted murine HS/PCs and detected an upregulation of Gata2 mRNA (2.0±0.2 fold, P=0.004) upon TGFβ-treatment of LSKCD34+ cells, while LSKCD34− cells were unaffected. Importantly, Gata2 upregulation was still observed after cycloheximide treatment, implying that Gata2 is a direct target of TGFβ signaling. Moreover, the robust activation of both Gata2 and p57 gene expression in LSKCD34+ cells was not observed in TGFβ-treated Smad4−/− HS/PCs, demonstrating that TGFβ-induced regulation of these two genes is mediated through canonical TGFβ/Smad signaling. Since Gata2 has been implicated to have a role in HSC quiescence, we wanted to compare Gata2 mRNA levels in different HS/PC populations, to see if the expression correlated with HSC primitiveness. Murine BM cells were sorted into 3 compartments of cells based on surface markers: LSKCD34− CD48− CD150+, LSKCD34− and LSKCD34+ cells. qPCR analysis revealed 1.6-fold (P<0.02) higher Gata2 mRNA level in the most primitive LSKCD34− CD48− CD150+ cells compared to LSKCD34− cells, and the latter population in turn had 2.9-fold (P<0.001) higher Gata2 level than LSKCD34+ cells. The same trend was found when measuring the mRNA level of p57 in these populations. LSKCD34− CD48− CD150+ cells had 3.1-fold (P<0.02) higher p57 level compared to LSKCD34− cells, which in turn had 7.4-fold (P<0.03) higher level than LSKCD34+ cells. This clearly demonstrates a correlation between Gata2 and p57 expression and primitiveness of HSCs. Together, our results strongly indicate that Gata2 and p57 are mediators of the Smad-mediated TGFβ response in HSCs. We hypothesize that there is a transcriptional network, regulating Gata2, p57 and TGFβ signaling, that has a functional importance in keeping the stem cells in quiescence. We aim to delineate this regulatory circuit and further study its functional relevance in HSC proliferation and self-renewal. Disclosures: No relevant conflicts of interest to declare.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

35

Sudjijo, NFN. „Karakterisasi dan Evaluasi 10 Aksesi Salak di Sijunjung Sumatera Barat“. Buletin Plasma Nutfah 15, Nr. 2 (10.10.2016): 75. http://dx.doi.org/10.21082/blpn.v15n2.2009.p75-79.

Der volle Inhalt der Quelle

Annotation:

The study was conducted at the farmer&rsquo;s field in Ujung Batu Sijunjung, West Sumatera using local Salacca cultivars developed from crossing between cultivar Pondoh as female plant and indigenous salak of Sumatera as male plant. This study was held from January 2003 until December 2005. The objective of this study was to develop database of Salacca characters by exploration method and using data passport model. The research result showed that five accessions with yellowish white fruits and the other five accessions with white fruits. The plant that produced fruit with good quality was SNJ-01 and thick flesh (0.57 cm), sweet (18,00oBrix in TSS), crispy, yellowish white in color and contains water 77.02%. AbstrakPenelitian ini dilakukan di kebun petani Desa Ujung Batu Kabupaten Sijunjung Sumatera Barat dengan menggunakan materi tanaman salak yang ada di daerah tersebut yang berasal dari persilangan antara induk betina salak Pondoh dan jantan indigenous Sumatera. Penelitian dilakukan pada bulan Januari 2003 sampai dengan Desember 2005 dan bertujuan untuk menyusun database karakter tanaman salak, metode yang digunakan adalah eksplorasi dan pengumpulan database menggunakan model paspor data. Hasil penelitian diperoleh deskripsi 5 aksesi yang warna buahnya putih kekuningan dan 5 aksesi yang warna buahnya putih. Tanaman yang menghasilkan buah dengan mutu baik, yaitu aksesi nomor SNJ-01, di mana daging buahnya tebal (0,57 cm), manis (PTT = 18,00oBrix), masir, berwarna putih kekuningan, dan kadar air (7,02%).

APA, Harvard, Vancouver, ISO und andere Zitierweisen

36

Zviahina, O., S. Shevchuk und O. Pavliuk. „AB1068 THE ROLE OF HEPCIDIN IN THE FORMATION OF ANEMICAL SYNDROME IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND ITS SIGNIFICANCE IN THE DIFFERENTIATION OF ANEMIA OF CHRONIC DISEASE, IRON DEFICIENCY ANEMIA AND THEIR COMBINATION“. Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 1755.2–1755. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3852.

Der volle Inhalt der Quelle

Annotation:

BackgroundAnemia is a frequent comorbid condition in ankylosing spondylitis (AS) patients. Anemia of chronic disease (ACD), iron deficiency anemia (IDA) and their combination are most often found in patients. The differential diagnosis between ACD and IDA is important because they require different treatment and at the same time is complicated due to the presence of an inflammatory component.ObjectivesTo establish the role of hepcidin in the formation of anemic syndrome in AS patients and its significance in differentiating anemia of chronic disease, iron deficiency anemia and their combination.MethodsThe study included 76 patients diagnosed with AS according to the modified New York criteria (1984) and 26 controls. Among them, there were 47 patients without anemia and 29 patients with anemia (IDA, n=7; ACD with iron deficiency, n=6; ACD, n=15, folate deficiency anemia, n=1). The diagnostic list included a complete blood count, serum iron, total iron-binding capacity, transferrin saturation, serum ferritin, soluble transferrin receptors (sTfR), and hepcidin. In the literature, there are no clear criteria for gradation of hepcidin levels, therefore, for further analysis, a percentile comparison was performed and indicators corresponding to P25 (up to 25 ng/ml), P25 - P75 (25-35 ng/ml) and P75 (above 35 ng/ml) were selected control group. The statistical processing of the obtained results was carried out using the Microsoft Office Excel 2007 statistical software package.ResultsIn the group of AS patients, 41 patients (54%) had hepcidin levels >P75, 16 (21%) - <P25, and 19 (25%) within P25 - P75. Hepcidin levels in patients with anemia were 1.4 times higher (51.77 ± 4.62 ng/ml) than in people without anemia (36.08 ± 2.57 ng/ml). The level of hepcidin (35.84±7.50 ng/ml) in patients with IDA is practically comparable to the group of patients without anemia. The level of hepcidin (62.78±5.94 ng/ml) is 1.7 times higher in people with ACD than in people with IDA (p<0.05). Patients with ACD and iron deficiency in terms of hepcidin level occupy an intermediate place (48.53±9.50 ng/ml), which may indicate an important role in the pathogenesis of ACD and can be used as a diagnostic marker for the differential diagnosis of ACD and IDA. In the group of patients without anemia, we found no significant relationship between hepcidin and indicators of red blood and ferrokinetics. While in individuals with anemia we found the relationship of hepcidin with serum iron (r=0.26; p<0.05), soluble transferrin receptors (r=-0.15; p<0.05) and transferrin saturation coefficient (r=0.17; p<0.05).ConclusionFor AS patients, for the early differential diagnosis of the types of anemia (ACD, IDA, and ACD with iron deficiency), in addition to traditional methods, the complex of laboratory tests should include determination of the hepcidin level in blood serum. A high level of hepcidin indicates the presence of ACD.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

37

Henjum, Sigrun, Ingrid Barikmo, Tor A. Strand, Arne Oshaug und Liv Elin Torheim. „Iodine-induced goitre and high prevalence of anaemia among Saharawi refugee women“. Public Health Nutrition 15, Nr. 8 (07.11.2011): 1512–18. http://dx.doi.org/10.1017/s1368980011002886.

Der volle Inhalt der Quelle

Annotation:

AbstractObjectiveThe main objective was to assess iodine status (thyroid volume (Tvol) and urinary iodine concentration (UIC)) and their determinants in Saharawi refugee women.DesignA cross-sectional survey was performed during January–February 2007. Tvol was measured by ultrasound and iodine concentration was analysed in spot urine samples and in household drinking water. Anthropometry and Hb concentration were measured and background variables were collected using pre-coded questionnaires.SettingThe survey was undertaken in four long-term refugee camps in the Algerian desert.SubjectsNon-pregnant women (n 394), 15–45 years old, randomly selected.ResultsMedian (25th percentile–75th percentile (P25–P75)) UIC was 466 (294–725) μg/l. Seventy-four per cent had UIC above 300 μg/l and 46 % above 500 μg/l. Median (P25–P75) Tvol was 9·4 (7·4–12·0) ml and the goitre prevalence was 22 %. UIC was positively associated with iodine in drinking water and negatively associated with breast-feeding, and these two variables explained 28 % of the variation in UIC. The mean (sd) Hb level was 11·8 (2·4) g/dl. In total 46 % were anaemic with 14 %, 25 % and 7 %, classified with respectively mild, moderate and severe anaemia.ConclusionsThe Saharawi women had high UIC, high levels of iodine in drinking water and increased Tvol and probably suffered from iodine-induced goitre. The high prevalence of anaemia is considered to be a severe public health concern. To what extent the excessive iodine intake and the anaemia have affected thyroid function is unknown and should be addressed in future studies.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

38

Fox, S. L., T. F. Townley-Smith, D. G. Humphreys, B. D. McCallum, T. G. Fetch, D. A. Gaudet, J. A. Gilbert, J. G. Menzies, J. S. Noll und N. K. Howes. „Somerset hard red spring wheat“. Canadian Journal of Plant Science 86, Nr. 1 (01.01.2006): 163–67. http://dx.doi.org/10.4141/p05-117.

Der volle Inhalt der Quelle

Annotation:

Somerset is a hard red spring wheat that meets the end-use quality and kernel visual distinguishability specifications of the Canada Western Red Spring class. Evaluation of Somerset occurred in the Central Bread Wheat Cooperative Registration Test in 2001, 2002 and 2003 and was found to be adapted to the wheat-growing regions of the Canadian prairies. In comparison to the check cultivars Katepwa, McKenzie, CDC Teal, AC Barrie and Superb, Somerset grain yield was intermediate to AC Barrie and McKenzie. Somerset is resistant to stem rust, leaf rust and loose smut. Resistance to fusarium head blight was similar to that of AC Barrie, Katepwa and McKenzie. End-use quality tests identified that Somerset had about 1% more grain protein and slightly higher flour yield than the check cultivars. Somerset has lower test weight and is taller than the check cultivars. Key words: Triticum aestivum L., cultivar description, red spring wheat, grain protein

APA, Harvard, Vancouver, ISO und andere Zitierweisen

39

Garcia-Manero, Guillermo, Carlos Bueso-Ramos, Lianchun Xiao, Koyu Hoshino, Gary Rosner, Sherry Pierce und Hui Yang. „Detection of Residual p73 DNA Methylation Predicts for Shorter Disease Free and Overall Survival in Patients (pts) with Philadelphia (Ph) Chromosome Negative Acute Lymphocytic Leukemia (ALL) in Remission.“ Blood 108, Nr. 11 (01.11.2006): 2333. http://dx.doi.org/10.1182/blood.v108.11.2333.2333.

Der volle Inhalt der Quelle

Annotation:

Abstract Aberrant DNA methylation of multiple promoter CpG islands is a common feature of ALL. Specific DNA methylation patterns involving a triad of hierarchical clustered cell cycle controlling genes including p73, p15 and p57KIP2 predict for poor prognosis in Ph negative ALL (Garcia-Manero, Blood, 2003). Of importance, this aberrant DNA methylation patterns are stable at the time of relapse in a majority of patients. This indicates that aberrant DNA methylation is a fundamental molecular feature of the ALL blast cell (Garcia-Manero, Clinical Cancer Research, 2002). Based on this, we hypothesized that the detection of residual DNA methylation in patients with standard risk (Ph negative) ALL could predict for shorter disease free survival, and worse overall survival (OS) in this patient population. To test this hypothesis, we have analyzed the frequency of p73, p15 and p57KIP2 DNA methylation at the time of initial documentation of complete remission (CR) (days 14 to 21) in 199 patients in CR with Ph negative ALL. All patients had been treated with hyperCVAD-based chemotherapy at our institution. To perform this analysis, we have developed a sensitive and specific novel real-time methylation specific PCR assay to detect DNA methylation. This method requires bisulfite DNA conversion. It uses the interferon-gamma gene as a DNA loading control and can be performed in less than 24 hours. The characteristics of the 199 patients evaluated are: median age 38 years (range 15–83), cytogenetics: 32% diploid, 5% hyper or hypodiploid, 20% insufficient metaphases and 3% MLL+, the rest others. 16% were of T cell phenotype. Using this assay, p73 methylation was detected in 18 (10%) patients, p15 in 33 (16%) and p57KIP2 in 7 (3.5%). Methylation of at least 1 gene of this triad was observed in 48 (24%) patients. The median OS of the whole group was 209 weeks (95% CI 158–514) and the disease free survival (DFS) 146 weeks (95% CI 110–335). These were representative of the overall experience with hyperCVAD at MDACC. By multivariate analysis, the presence of residual p73 methylation on days 14 to 21 in patients with Ph negative ALL was associated with a shorter DFS (hazard ratio 2.68, p=0.003) and a worse OS (hazard ratio 2.69, p=0.002). This was independent of any other patient characteristic. Other characteristic included in these models included age and platelet count for OS, and age, b2-microglobulin, LDH and platelets for DFS. The presence of p15, p57KIP2 methylation or the combination of multiple genes was not associated with shorter OS or DFS. In summary, the detection of residual p73 methylation allows the identification of a subset of patients with ALL in remission and worse prognosis. This data may allow the development of specific therapeutic interventions, such as the use of hypomethylating agents, or early allogeneic stem cell transplantation for this at-risk patient population, and suggest that inactivation of p73 is a key event in ALL.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

40

Alonso, Silvia Patricia, Sergio Valdés, Cristina Maldonado-Araque, Ana Lago, Pilar Ocon, Alfonso Calle, Luis Castaño et al. „Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study“. European Journal of Endocrinology 186, Nr. 1 (01.01.2022): 95–103. http://dx.doi.org/10.1530/eje-21-0640.

Der volle Inhalt der Quelle

Annotation:

Objective It has been proposed that a mild form of acquired resistance to thyroid hormone may occur in the general population. Its clinical significance remains largely unknown. The objective of the study was to explore whether a newly described thyroid hormone resistance index is associated with the risk of mortality in a sample of community-dwelling euthyroid subjects representative of the adult population of Spain. Design Longitudinal observational study including 3750 individuals, free of thyroid disease, TPO antibodies-negative (<50 IU/mL) and with TSH levels within the euthyroid range (≥0.5 and ≤5.0 mUI/mL) participating in the nationwide study Di@bet.es (2008–2010). Methods We used the Thyroid Feedback Quantile-based Index (TFQI) as a marker of resistance to thyroid hormone. The study population was grouped into categories according to their TFQI values at baseline. Fatal events were ascertained from the national death registry (end of follow-up December 2016). Results A total of 231 deaths were recorded during an average follow-up of 7.3 years. Compared with the category with the highest sensitivity to free thyroxine (TFQI ≤ p5) (reference), the relative risk of mortality in the categories with TFQI > p5 and ≤p25; >p25 and ≤p50; >p50 and ≤p75; >p75 and ≤p95 and >p95 were 1.01, (0.47–2.19), 1.42 (0.68–2.97), 1.54 (0.74–3.22), 1.47 (0.70–3.11) and 2.61 (1.16–5.89), respectively (P for trend 0.003). The association remained significant after multivariate adjustment of the data (P for trend 0.017). Conclusions A thyroid hormone resistance index focused on deviations of the average pituitary response to thyroid hormones may be associated with all-cause mortality independently of other conventional risk factors and comorbidities.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

41

Olesen, Oliver Juul, Naja Emborg Vinding, Lauge Østergaard, Jawad H. Butt, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Køber und Emil Loldrup Fosbøl. „C-reactive protein after coronary artery bypass graft surgery and its relationship with postoperative atrial fibrillation“. EP Europace 22, Nr. 8 (05.07.2020): 1182–88. http://dx.doi.org/10.1093/europace/euaa088.

Der volle Inhalt der Quelle

Annotation:

Abstract Aims Postoperative atrial fibrillation (POAF), a common complication following coronary artery bypass graft (CABG) surgery, is associated with increased morbidity and mortality. Inflammation may be an important factor for the pathogenesis of POAF, and increased preoperative levels of C-reactive protein (CRP) are associated with the development of POAF. However, the relationship between postoperative CRP and POAF is less well established. Methods and results Patients undergoing first-time isolated CABG surgery (1 January 2000–31 December 2016) were identified using the Eastern Danish Heart Surgery Database and nationwide administrative registries. Patients with no history of atrial fibrillation and with available CRP measurements from postoperative day (POD) 4 were included. The study population was divided into quartiles based on CRP. The association between CRP levels and the odds of developing POAF was investigated using multivariable logistic regression analysis. We included 6711 patients. The CRP intervals on POD 4 for the CRP groups (lowest to highest) were ≤90, >90 to ≤127, >127 to ≤175, and >175 mg/L, respectively. Patients in the highest CRP group were older and more often men compared with patients in the lowest CRP group [median age 67 years (P25–P75: 61–73) and 84.7% men vs. median age 64 years (P25–P75: 56–70) and 77.9% men]. In the lowest and highest CRP groups, 25% and 35% developed POAF, respectively. In adjusted analysis, the highest CRP group, compared with the lowest CRP group, was associated with greater odds of developing POAF (odds ratio 1.31; 95% confidence interval 1.12–1.54). Conclusion Increased postoperative CRP levels after CABG surgery was associated with the development of POAF.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

42

Nakamura, Takahiro, Ken-ichi Endo und Shigeru Kinoshita. „Identification of Human Oral Keratinocyte Stem/Progenitor Cells by Neurotrophin Receptor p75 and the Role of Neurotrophin/p75 Signaling“. STEM CELLS 25, Nr. 3 (16.11.2006): 628–38. http://dx.doi.org/10.1634/stemcells.2006-0494.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

43

Shen, LanLan, Minoru Toyota, Yutaka Kondo, Toshiro Obata, Sophia Daniel, Sherry Pierce, Kohzoh Imai, Hagop M. Kantarjian, Jean-Pierre J. Issa und Guillermo Garcia-Manero. „Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia“. Blood 101, Nr. 10 (15.05.2003): 4131–36. http://dx.doi.org/10.1182/blood-2002-08-2466.

Der volle Inhalt der Quelle

Annotation:

Abstract P57KIP2 is a cyclin-dependent kinase inhibitor silenced in a variety of human malignancies. DNA methylation of a region surrounding the transcription start site of p57KIP2 was found in acute lymphocytic leukemia (ALL)–derived cell lines. Methylation of this region correlated with gene silencing, and treatment of methylated/silenced cell lines with 5-aza-2′-deoxycytidine resulted in gene re-expression. P57KIP2 was methylated in 31 (50%) of 63 patients with newly diagnosed ALL, and in 11 (52%) of 21 patients with relapsed ALL. In 5 of them (25%), methylation was acquired at relapse. No association was observed between methylation of p57KIP2 alone and clinical-biologic characteristics studied, including overall survival (OS) or disease-free survival. Methylation of multiple genes in a cell-cycle regulatory pathway composed of p73, p15, and p57KIP2 occurred in 22% of Philadelphia chromosome (Ph)–negative patients. Ph-negative patients with methylation of 2 or 3 genes of this pathway had a significantly worse median OS compared with those with methylation of 0 or 1 gene (50 vs 467 weeks, respectively;P = .02). Our results indicate that p57KIP2 is frequently methylated in adult patients with ALL, and that inactivation of a pathway composed of p73, p15, and p57KIP2 predicts for poor prognosis in Ph-negative patients.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

44

Sikkema, P. H., N. Soltani, C. Shropshire und D. E. Robinson. „Response of adzuki bean to pre-emergence herbicides“. Canadian Journal of Plant Science 86, Nr. 2 (05.05.2006): 601–4. http://dx.doi.org/10.4141/p05-150.

Der volle Inhalt der Quelle

Annotation:

Limited herbicide options are available to adzuki bean growers in southwestern Ontario. Six field trials were conducted in Ontario during 2003 and 2004 to evaluate the tolerance of adzuki bean to dimethenamid (1250 and 2500 g a.i. ha-1), S-metolachlor (1600 and 3200 g a.i. ha-1), clomazone (1000 and 2000 g a.i. ha-1), and imazethapyr (75 and 150 g a.i. ha-1) applied pre-emergence. Dimethenamid caused up to 37% visual injury and reduced plant height, shoot dry weight and yield 27, 59 and 52%, respectively. Seed maturity was also delayed by dimethenamid at 2500 g ha-1. S-metolachlor caused up to 34% visual inj ury and reduced plant height, shoot dry weight and yield 27, 48 and 48%, respectively. Clomazone caused 53% visual injury and reduced plant height, shoot dry weight and yield 47, 84 and 78%, respectively. Imazethapyr caused up to 6% visual injury; however, this injury was transient with no adverse effect on plant height, shoot dry weight, seed moisture content and yield of adzuki bean. Based on these results, dimethenamid, S-metolachlor and clomazone applied pre-emergence (PRE) do not have an adequate margin of crop safety for use in adzuki bean at the doses evaluated. However, imazethapyr applied PRE has an adequate margin of crop safety for weed management in adzuki bean production in Ontario at the doses evaluated. Key words: Clomazone, dimethenamid, imazethapyr, S-metolachlor, tolerance

APA, Harvard, Vancouver, ISO und andere Zitierweisen

45

Sholberg, Peter L., Denis A. Gaudet, Byron Puchalski und Paul Randall. „Control of common bunt (Tilleta tritici and T. laevis) of wheat (Triticum aestivum cv. ‘Laura’) by fumigation with acetic acid vapour“. Canadian Journal of Plant Science 86, Nr. 3 (07.07.2006): 839–43. http://dx.doi.org/10.4141/p05-176.

Der volle Inhalt der Quelle

Annotation:

Common bunt caused by Tilletia tritici and T. laevis remains an important disease of wheat, particularly in organic production where effective fungicides are not available. Acetic acid (AA), a potential organic seed fumigant, was evaluated for control of common bunt of wheat. The highly susceptible spring wheat cultivar Laura was inoculated with bunt spores and then fumigated with 2 and 4 g kg-1 AA vapour in 23 L chambers for 1 h at 20°C. Fumigation reduced field infection levels of common bunt in trials conducted at Lethbridge, AB during 2000, 2001, and 2003. The 4 g kg-1 rate was more effective than the 2 g kg-1 rate in reducing bunt infection, although both rates were as effective as Vitavax, the standard seed-treatment fungicide treatment. Some reduction in tiller numbers was associated with the AA treatments especially at the 4 g kg-1 rate. In vitro tests on artificial growth media showed that AA significantly decreased seed-borne mold contamination caused by several species of fungi. Acetic acid fumigation could be an important organic alternative to fungicides for control of common bunt. Key words: Covered smut, organic, seed treatment, stinking smut, vinegar

APA, Harvard, Vancouver, ISO und andere Zitierweisen

46

Angelotti, Rangel, und M. A. Noernberg. „Análise Dos Riscos Ao Banho De Mar No Município De Pontal Do Paraná - PR – Temporada 2003/2004“. Brazilian Journal of Aquatic Science and Technology 14, Nr. 1 (07.06.2010): 65. http://dx.doi.org/10.14210/bjast.v14n1.p65-75.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

47

Aguilar, Sergio Luiz Cruz, und Maria Eduarda Guerra. „JUSTIÇA, RESPONSABILIZAÇÃO E RECONCILIAÇÃO: OS CASOS DAS CRIANÇAS SOLDADOS NOS CONFLITOS ARMADOS DA LIBÉRIA, SERRA LEOA E UGANDA“. Revista Eletrônica Direito e Política 17, Nr. 1 (09.06.2022): 73–105. http://dx.doi.org/10.14210/rdp.v17n1.p73-105.

Der volle Inhalt der Quelle

Annotation:

Este artigo debate a questão das crianças soldados, em relação ao seu recrutamento por grupos armados, aos processos de reintegração e responsabilização pelos crimes cometidos quando membros dos grupos armados. Utiliza a pesquisa qualitativa que inclui os estudos dos casos das guerras civis da Libéria (1989-2003) e Serra Leoa (1991-2002), e da insurgência no norte de Uganda (1986-2008). Utilizamos o método de abordagem dedutivo a partir de fontes primárias e secundárias. O argumento é que, apesar da dinâmica dos recrutamentos ser semelhante, a decisão de como lidar com a responsabilização criminal das ex-crianças soldados tem relação com o tipo de conflito vivido pelo Estado e o entendimento de como deve ser a justiça no contexto da reconciliação nacional. O artigo conclui que, embora os três casos possuam semelhanças em relação ao recrutamento e uso de crianças nos conflitos, a reintegração e a responsabilização se deram de modos diferentes.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

48

Pérez-Simón, José A., María Díez-Campelo, Rodrigo Martino, Anna Sureda, Dolores Caballero, Consuelo Cañizo, Salut Brunet et al. „Impact of CD34+ cell dose on the outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation“. Blood 102, Nr. 3 (01.08.2003): 1108–13. http://dx.doi.org/10.1182/blood-2002-11-3503.

Der volle Inhalt der Quelle

Annotation:

Abstract We analyzed the impact of CD34+ cell dose on the outcome of 86 patients undergoing reduced-intensity conditioning (RIC) allogeneic peripheral blood stem cell transplantation. The RIC was based on fludarabine 150 mg/m2 and melphalan 140 mg/m2 or busulphan 10 mg/kg. A median of 5.68 × 106 CD34+ cells/kg and 2.86 × 108 CD3+ cells/kg were infused. All patients receiving more than percentile 75 (p75) of CD34+ cells reached complete chimerism in T lymphocytes by days 21 to 28, compared with 44% among those receiving p75 or fewer cells (P = .046). Overall, 30.3% patients developed grade 2 to 4 acute graft-versus-host disease (aGVHD). Among 83 evaluable patients, 55.8% developed chronic GVHD (cGVHD). The dose of CD34+ cells infused did influence the development of cGVHD, with a cumulative incidence of extensive cGVHD of 74% vs 47% (P = .02) among patients receiving more than p75 CD34+ cells vs those receiving p75 or fewer. Projected overall survival (OS) and event-free survival (EFS) at 43 months were 60% and 46%, respectively. Neither the dose of CD34+ cells nor the dose of CD3+ cells infused significantly influenced OS and EFS, although among patients categorized as high-risk, 36% of those receiving p75 or fewer CD34+ cells relapsed or progressed, compared with only 9% among those receiving more than p75 CD34+ cells (P = .07). Among patients receiving p75 or fewer CD34+ cells, 36% of high-risk patients relapsed, compared with 10% of low- and intermediate-risk patients (P = .004), while relapse rates were not significantly different between both subgroups when we infused more than p75 CD34+ cells, thus indicating that infusing high doses of CD34+ cells ameliorates the negative effect of advanced disease status at transplantation. cGVHD was associated with better EFS (63% vs 16% at 43 months for patients with and without cGVHD; P < .0001) and better OS (78% vs 28% for patients with and without cGHVD; P < .001). The number of CD34+ cells infused should be tailored to prevent extensive cGVHD among patients categorized as low-risk, while high-risk patients, in whom the graft-versus-leukemia effect may determine disease outcome, should receive high doses of CD34+ cells.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

49

Guimarães, Tatiane De Araújo Almeida Studart, Aluiza Alves de Araújo und Maria Lidiane De Sousa Pereira. „Os pronomes você(s) e cê(s) no falar de Fortaleza-CE“. Letras Escreve 8, Nr. 2 (23.05.2019): 75. http://dx.doi.org/10.18468/letras.2018v8n2.p75-101.

Der volle Inhalt der Quelle

Annotation:

Com base na Sociolinguística Variacionista (LABOV, 1968, 1990, 2006, 2008; WEINREICH; LABOV; HERZOG, 2006), investigamos a variação entre você(s) e cê(s) no falar de Fortaleza com base em dados do Projeto Norma Oral do Português Popular de Fortaleza (NORPOFOR). Intentamos analisar a influência de variáveis linguísticas e/ou extralinguísticas sobre o uso das formas você(s) e cê(s). As análises estatísticas indicam que, na amostra deste trabalho, a variante cê(s) compreende 5,30% dos casos e a variante você(s) aparece em 95,70% dos dados. Verificamos também que a primeira variante é beneficiada, exclusivamente, por variáveis extralinguísticas, a saber: escolaridade (0-4 e 9-11 anos de escolaridade), sexo (homens) e grau de intimidade entre os informantes (alto grau de intimidade), nessa mesma ordem de relevância.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

50

Juszczynski, Przemyslaw, Ewa Kalinka, Jacques Bienvenu, Grzegorz Woszczek, Maciej Borowiec, Tadeusz Robak, Marek Kowalski et al. „Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome“. Blood 100, Nr. 8 (15.10.2002): 3037–40. http://dx.doi.org/10.1182/blood-2002-02-0654.

Der volle Inhalt der Quelle

Annotation:

Tumor necrosis factor (TNF) production and non-Hodgkin lymphoma (NHL) outcome was found to be related to the TNF−308polymorphism. To explore whether this could be linked to neighboring polymorphisms, we genotyped the TNF−376,−308,−238,−163, lymphotoxin alpha (LTα)+252, and HLA DRB1 alleles in 204 patients with NHL and 120 controls. TNF−308A was the only allele associated with higher TNF and its p55 and p75 receptors' levels (P = .009, P = .03, andP = .007) and lower complete remission rates (P = .006). Freedom from progression (FFP) and overall survival (OS) were shorter in patients with TNF−308A(P = .009 and P = .02), null HLA DRB1*02 allele (P = .007 and P = .14), or both genetic markers (P = .004 and P = .005). Multivariate analysis incorporating International Prognostic Index (IPI) identified TNF−308A (P < .0001, relative risk [RR] = 1.63; P < .0001, RR = 1.51) and null HLA DRB1*02 alleles (P = .015, RR = 1.18;P < .0001, RR = 1.25) as independent factors for FFP and OS. These results indicate the existence of at least 2 inherited factors involved in NHL outcome.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Zeitschriftenartikel zum Thema „P75 2004“

Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an