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Auswahl der wissenschaftlichen Literatur zum Thema „ONNV“

Autor: Grafiati

Veröffentlicht am 25. Mai 2024

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Zeitschriftenartikel zum Thema "ONNV"

Makio, Albina, Lillian Musila, Eddy Okoth Odari, Juliette Rose Ongus und Rosemary Sang. „The Potential of O’nyong-nyong Virus Strain SG650 Murine Monoclonal Antibodies for Detection of O’nyong-nyong and Chikungunya Viruses“. East African Journal of Health and Science 3, Nr. 1 (05.08.2021): 97–114. http://dx.doi.org/10.37284/eajhs.3.1.377.

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O’nyong-nyong virus (ONNV) and Chikungunya virus (CHIKV) are antigenically related alphaviruses responsible for febrile illnesses common to the tropics and associated with relatively high morbidity and mortality. Murine monoclonal antibodies (mAbs) targeting alphaviruses like Chikungunya have been developed and used to make commercially available kits. However, few studies have been conducted to develop antibodies specific to ONNV and no commercial kits are available for use in endemic regions where outbreak potential is high. We demonstrate the potential of in-house generated monoclonal antibodies against ONNV to detect both ONNV and CHIKV. The objective of this study was to generate mAbs using hybridoma technology, characterize the developed mAbs, determine their specificity against selected alphaviruses and check their diagnostic potential using an indirect IgG enzyme-linked immunosorbent assay (ELISA) and focus neutralization assay (FRNT50). BALB/c mice were immunized with ONNV purified proteins from ONNV infectious culture fluid. After four rounds of booster injections, the mice were sacrificed, spleen cells harvested and fused with parental myeloma cells then cultured in selective media and the successful hybrid clones with antibody-producing ability purified to yield the desired mAbs. Five monoclonal antibodies targeting the ONNV E1 protein of isotypes IgG2a/kappa, IgG2b/kappa and IgM/kappa (P1B12, P1E9, P1G11, P1B4 and P1G6) demonstrated a potential to detect both ONNV and CHIKV isolates by indirect IgG ELISA but no potential for neutralization of the viruses by FRNT50. This study demonstrates the potential efficacy of in-house serological tools as an alternative in the absence of commercial assays in screening and diagnosis of ONN and CHIK viruses which are often co-circulating. It is our recommendation that this work may be pursued further to design and optimize ELISA assays, using the developed mAbs, for the detection of both ONN and CHIK viruses in the research laboratory set-up

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Myles, Kevin M., Cindy L. H. Kelly, Jeremy P. Ledermann und Ann M. Powers. „Effects of an Opal Termination Codon Preceding the nsP4 Gene Sequence in the O'Nyong-Nyong Virus Genome on Anopheles gambiae Infectivity“. Journal of Virology 80, Nr. 10 (15.05.2006): 4992–97. http://dx.doi.org/10.1128/jvi.80.10.4992-4997.2006.

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ABSTRACT The genomic RNA of an alphavirus encodes four different nonstructural proteins, nsP1, nsP2, nsP3, and nsP4. The polyprotein P123 is produced when translation terminates at an opal termination codon between nsP3 and nsP4. The polyprotein P1234 is produced when translational readthrough occurs or when the opal termination codon has been replaced by a sense codon in the alphavirus genome. Evolutionary pressures appear to have maintained genomic sequences encoding both a stop codon (opal) and an open reading frame (arginine) as a general feature of the O'nyong-nyong virus (ONNV) genome, indicating that both are required at some point. Alternate replication of ONNVs in both vertebrate and invertebrate hosts may determine predominance of a particular codon at this locus in the viral quasispecies. However, no systematic study has previously tested this hypothesis in whole animals. We report here the results of the first study to investigate in a natural mosquito host the functional significance of the opal stop codon in an alphavirus genome. We used a full-length cDNA clone of ONNV to construct a series of mutants in which the arginine between nsP3 and nsP4 was replaced with an opal, ochre, or amber stop codon. The presence of an opal stop codon upstream of nsP4 nearly doubled (75.5%) the infectivity of ONNV over that of virus possessing a codon for the amino acid arginine at the corresponding position (39.8%). Although the frequency with which the opal virus disseminated from the mosquito midgut did not differ significantly from that of the arginine virus on days 8 and 10, dissemination did began earlier in mosquitoes infected with the opal virus. Although a clear fitness advantage is provided to ONNV by the presence of an opal codon between nsP3 and nsP4 in Anopheles gambiae, sequence analysis of ONNV RNA extracted from mosquito bodies and heads indicated codon usage at this position corresponded with that of the virus administered in the blood meal. These results suggest that while selection of ONNV variants is occurring, de novo mutation at the position between nsP3 and nsP4 does not readily occur in the mosquito. Taken together, these results suggest that the primary fitness advantage provided to ONNV by the presence of an opal codon between nsP3 and nsP4 is related to mosquito infectivity.

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Shah, Melisa M., Bryson A. Ndenga, Francis M. Mutuku, Victoria Okuta, Charles O. Ronga, Philip K. Chebii, Priscilla Maina et al. „No Evidence of O’nyong-nyong Viremia among Children with Febrile Illness in Kenya (2015–2018)“. American Journal of Tropical Medicine and Hygiene 104, Nr. 4 (07.04.2021): 1435–37. http://dx.doi.org/10.4269/ajtmh.20-0580.

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ABSTRACTO’nyong-nyong virus (ONNV) is a little-known arbovirus causing intermittent, yet explosive, outbreaks in Africa. It is closely related to chikungunya virus, an emerging infectious disease. O’nyong-nyong virus causes a self-limited illness characterized by bilateral polyarthritis, rash, low-grade fever, and lymphadenopathy. In 1959, an extensive outbreak of ONNV occurred in East Africa, and decades later, another large outbreak was documented in Uganda in 1996. Limited evidence for interepidemic transmission is available, although serologic studies indicate a high prevalence of exposure. 1,045 febrile child participants in western and coastal Kenya were tested for the presence of ONNV using a multiplexed real-time reverse transcriptase–PCR assay. More than half of the participants had malaria parasitemia, and there was no evidence of active ONNV viremia in these participants. Further work is required to better understand the interepidemic circulation of ONNV and to reconcile evidence of high serologic exposure to ONNV among individuals in East Africa.

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Kading, Rebekah C., Erin M. Borland, Eric C. Mossel, Teddy Nakayiki, Betty Nalikka, Jeremy P. Ledermann, Mary B. Crabtree et al. „Exposure of Egyptian Rousette Bats (Rousettus aegyptiacus) and a Little Free-Tailed Bat (Chaerephon pumilus) to Alphaviruses in Uganda“. Diseases 10, Nr. 4 (05.12.2022): 121. http://dx.doi.org/10.3390/diseases10040121.

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The reservoir for zoonotic o’nyong-nyong virus (ONNV) has remained unknown since this virus was first recognized in Uganda in 1959. Building on existing evidence for mosquito blood-feeding on various frugivorous bat species in Uganda, and seroprevalence for arboviruses among bats in Uganda, we sought to assess if serum samples collected from bats in Uganda demonstrated evidence of exposure to ONNV or the closely related zoonotic chikungunya virus (CHIKV). In total, 652 serum samples collected from six bat species were tested by plaque reduction neutralization test (PRNT) for neutralizing antibodies against ONNV and CHIKV. Forty out of 303 (13.2%) Egyptian rousettes from Maramagambo Forest and 1/13 (8%) little free-tailed bats from Banga Nakiwogo, Entebbe contained neutralizing antibodies against ONNV. In addition, 2/303 (0.7%) of these Egyptian rousettes contained neutralizing antibodies to CHIKV, and 8/303 (2.6%) contained neutralizing antibodies that were nonspecifically reactive to alphaviruses. These data support the interepidemic circulation of ONNV and CHIKV in Uganda, although Egyptian rousette bats are unlikely to serve as reservoirs for these viruses given the inconsistent occurrence of antibody-positive bats.

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Kamau, Kevin K., Gabriel Magoma, Allan Ole Kwallah, Charles K. Syengo und Matilu Mwau. „Seroprevalence of chikungunya fever virus and O’nyong Nyong fever virus among febrile patients visiting selected hospitals in 2011-2012 Trans Nzoia County, Kenya“. International Journal of Research in Medical Sciences 6, Nr. 6 (25.05.2018): 1913. http://dx.doi.org/10.18203/2320-6012.ijrms20182271.

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Background: Chikungunya virus (CHIKV) is an alphavirus in the Semliki Forest complex, and is most closely related to O’Nyong Nyong virus (ONNV). CHIKV and ONNV are mosquito-borne alphaviruses endemic in East Africa that cause acute febrile illness and arthralgia. The objectives of this study were to measure seroprevalence of CHIKV and ONNV in selected health facilities in Western Kenya and link it to demographics and other risk factors.Methods: The study design was cross sectional in selected health facilities. We tested for anti-CHIKV antibodies using In-house Indirect IgG Enzyme Linked Immunosorbent Assay (ELISA) and In-house IgM Capture ELISA and confirmed with Focus Reduction Neutralization Test (FRNT) for specific alphavirus neutralizing antibodies against CHIKV or ONNV. Mean, median and standard deviation were used to summarize the data. Comparisons of means and medians were done using Student’s t test. Prevalence rates were determined using descriptive statistics (e.g. proportions, rates).Results: From the 382 samples that were successfully collected, 114 (29.84%) had anti-CHIKV antibodies by the ELISA test. Of these, 27 (7.1%) had CHIKV-specific neutralizing antibodies and 5 (1.3%) had ONNV-specific neutralizing antibodies. Age was significantly associated with seropositivity (OR=1.03; P=0.015, 95% C.I 1.01-1.06). Males were less likely to be seropositive (OR=0.67; P=0.358, 95% C.I 0.27-1.52). Risk factors associated with seropositivity included collecting firewood (OR=2.73 95% 1.13- 6.41) and walls with holes and cracks (OR=0.23 95% C.I 0.04 -0.86).Conclusions: Both CHIKV and ONNV infections were confirmed in the participants’ more so in women and adults, demonstrating undocumented and ongoing transmission in Western Kenya. In 2011 and 2012 CHIKV and ONNV contributed 8.4% of fevers presented in the three selected health facilities in Western Kenya.

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Torres-Ruesta, Anthony, Teck-Hui Teo, Yi-Hao Chan, Siti Naqiah Amrun, Nicholas Kim-Wah Yeo, Cheryl Yi-Pin Lee, Samantha Yee-Teng Nguee et al. „Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells“. Life Science Alliance 5, Nr. 4 (17.01.2022): e202101272. http://dx.doi.org/10.26508/lsa.202101272.

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O’nyongnyong virus (ONNV) is a re-emerging alphavirus previously known to be transmitted by main malaria vectors, thus suggesting the possibility of coinfections with arboviruses in co-endemic areas. However, the pathological outcomes of such infections remain unknown. Using murine coinfection models, we demonstrated that a preexisting blood-stage Plasmodium infection suppresses ONNV-induced pathologies. We further showed that suppression of viremia and virus dissemination are dependent on Plasmodium-induced IFNγ and are associated with reduced infection of CD45− cells at the site of virus inoculation. We further proved that treatment with IFNγ or plasma samples from Plasmodium vivax–infected patients containing IFNγ are able to restrict ONNV infection in human fibroblast, synoviocyte, skeletal muscle, and endothelial cell lines. Mechanistically, the role of IFNγ in restricting ONNV infection was confirmed in in vitro infection assays through the generation of an IFNγ receptor 1 α chain (IFNγR1)–deficient cell line.

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Payet, Melissa, Axelle Septembre-Malaterre, Philippe Gasque und Xavier Guillot. „Human Synovial Mesenchymal Stem Cells Expressed Immunoregulatory Factors IDO and TSG6 in a Context of Arthritis Mediated by Alphaviruses“. International Journal of Molecular Sciences 24, Nr. 21 (03.11.2023): 15932. http://dx.doi.org/10.3390/ijms242115932.

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Infection by arthritogenic alphaviruses (aavs) can lead to reactive arthritis, which is characterized by inflammation and persistence of the virus; however, its mechanisms remain ill-characterized. Intriguingly, it has been shown that viral persistence still takes place in spite of robust innate and adaptive immune responses, characterized notably by the infiltration of macrophages (sources of TNF-alpha) as well as T/NK cells (sources of IFN-gamma) in the infected joint. Aavs are known to target mesenchymal stem cells (MSCs) in the synovium, and we herein tested the hypothesis that the infection of MSCs may promote the expression of immunoregulators to skew the anti-viral cellular immune responses. We compared the regulated expression via human synovial MSCs of pro-inflammatory mediators (e.g., IL-1β, IL6, CCL2, miR-221-3p) to that of immunoregulators (e.g., IDO, TSG6, GAS6, miR146a-5p). We used human synovial tissue-derived MSCs which were infected with O’Nyong-Nyong alphavirus (ONNV, class II aav) alone, or combined with recombinant human TNF-α or IFN-γ, to mimic the clinical settings. We confirmed via qPCR and immunofluorescence that ONNV infected human synovial tissue-derived MSCs. Interestingly, ONNV alone did not regulate the expression of pro-inflammatory mediators. In contrast, IDO, TSG6, and GAS6 mRNA expression were increased in response to ONNV infection alone, but particularly when combined with both recombinant cytokines. ONNV infection equally decreased miR-146a-5p and miR-221-3p in the untreated cells and abrogated the stimulatory activity of the recombinant TNF-α but not the IFN-gamma. Our study argues for a major immunoregulatory phenotype of MSCs infected with ONNV which may favor virus persistence in the inflamed joint.

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Bedoui, Yosra, Dauriane De Larichaudy, Matthieu Daniel, Franck Ah-Pine, Jimmy Selambarom, Pascale Guiraud und Philippe Gasque. „Deciphering the Role of Schwann Cells in Inflammatory Peripheral Neuropathies Post Alphavirus Infection“. Cells 12, Nr. 1 (26.12.2022): 100. http://dx.doi.org/10.3390/cells12010100.

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Old world alphaviruses (e.g., chikungunya) are known to cause severe acute and chronic debilitating arthralgia/arthritis. However, atypical neurological manifestations and, in particular, unexpected cases of acute inflammatory Guillain–Barre syndrome (GBS) have been associated with the arthritogenic alphaviruses. The pathogenesis of alphavirus-associated GBS remains unclear. We herein addressed for the first time the role of Schwann cells (SC) in peripheral neuropathy post-alphaviral infection using the prototypical ONNV alphavirus model. We demonstrated that human SC expressed the recently identified alphavirus receptor MxRA8 and granting viral entry and robust replication. A canonical innate immune response was engaged by ONNV-infected SC with elevated gene expression for RIG-I, MDA5, IFN-β, and ISG15 and inflammatory chemokine CCL5. Transcription levels of prostaglandin E2-metabolizing enzymes including cPLA2α, COX-2, and mPGES-1 were also upregulated in ONNV-infected SC. Counterintuitively, we found that ONNV failed to affect SC regenerative properties as indicated by elevated expression of the pro-myelinating genes MPZ and MBP1 as well as the major pro-myelin transcription factor Egr2. While ONNV infection led to decreased expression of CD55 and CD59, essential to control complement bystander cytotoxicity, it increased TRAIL expression, a major pro-apoptotic T cell signal. Anti-apoptotic Bcl2 transcription levels were also increased in infected SC. Hence, our study provides new insights regarding the remarkable immunomodulatory role of SC of potential importance in the pathogenesis of GBS following alphavirus infection.

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Kay, Grant A., Edward I. Patterson, Grant L. Hughes, Jennifer S. Lord und Lisa J. Reimer. „Knockdown resistance allele L1014F introduced by CRISPR/Cas9 is not associated with altered vector competence of Anopheles gambiae for o’nyong nyong virus“. PLOS ONE 18, Nr. 8 (10.08.2023): e0288994. http://dx.doi.org/10.1371/journal.pone.0288994.

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Knockdown resistance (kdr) alleles conferring resistance to pyrethroid insecticides are widespread amongst vector populations. Previous research has suggested that these alleles are associated with changes in the vector competence of mosquitoes for arboviruses and Plasmodium, however non-target genetic differences between mosquito strains may have had a confounding effect. Here, to minimise genetic differences, the laboratory Anopheles gambiae Kisumu strain was compared to a CRISPR/Cas9 homozygous kdr L1014F mutant Kisumu-kdr line in order to examine associations with vector competence for o’nyong nyong virus (ONNV). Mosquitoes were infected using either blood feeds or intrathoracic microinjections. There were no significant differences in the prevalence of virus in mosquito body parts between kdr mutant and wildtype lines from either oral or intrathoracic injection routes. The ONNV titre was significantly higher in the legs of the wildtype strain at 7dpi following intrathoracic microinjection, but no other significant differences in viral titre were detected. ONNV was not detected in the saliva of mosquitoes from either strain. Our findings from per os infections suggest that the kdr L1014F allele is not associated with altered infection prevalence for ONNV, a key component of vector competence.

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Rakotomalala, Fetra Angelot, Julie Bouillin, Santatriniaina Dauphin Randriarimanana, Guillaume Thaurignac, Luca Maharavo, Mihaja Raberahona, Lucien Razafindrakoto et al. „High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar“. Viruses 15, Nr. 11 (15.11.2023): 2258. http://dx.doi.org/10.3390/v15112258.

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To estimate the prevalence of IgG antibodies against six arboviruses in people living with HIV-1 (PLWHIV) in Madagascar, we tested samples collected between January 2018 and June 2021. We used a Luminex-based serological assay to detect IgG antibodies against antigens from Dengue virus serotypes 1–4 (DENV1–4), Zika virus (ZIKV), West Nile virus (WNV), Usutu virus (USUV), Chikungunya virus (CHIKV), and O’nyong nyong virus (ONNV). Of the 1036 samples tested, IgG antibody prevalence was highest for ONNV (28.4%), CHIKV (26.7%), WNV-NS1 (27.1%), DENV1 (12.4%), USUV (9.9%), and DENV3 (8.9%). ZIKV (4.9%), DENV2 (4.6%), WNV-D3 (5.1%), and DENV4 (1.4%) were lower. These rates varied by province of origin, with the highest rates observed in Toamasina, on the eastern coast (50.5% and 56.8%, for CHIKV and ONNV, respectively). The seroprevalence increased with age for DENV1 and 3 (p = 0.006 and 0.038, respectively) and WNV DIII (p = 0.041). The prevalence of IgG antibodies against any given arborvirus varied over the year and significantly correlated with rainfalls in the different areas (r = 0.61, p = 0.036). Finally, we found a significant correlation between the seroprevalence of antibodies against CHIKV and ONNV and the HIV-1 RNA plasma viral load. Thus, PLWHIV in Madagascar are highly exposed to various arboviruses. Further studies are needed to explain some of our findings.

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Dissertationen zum Thema "ONNV"

Cottis, Solène. „Viral manipulation and vectorial specificity mediated by interaction with the G3BP protein, Rasputin in Anopheles mosquitoes“. Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS437.

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Contrairement aux moustiques Aedes aegypti, vecteurs du virus chikungunya (CHIKV) et de nombreux arbovirus tels que le virus de la dengue et le virus Zika, les moustiques Anopheles gambiae sont les vecteurs du parasite Plasmodium, agent causal du paludisme. La réponse des agents pathogènes chez les anophèles a été très étudiée pour Plasmodium en raison de l'importance clinique de cet agent pathogène dans le monde. Le seul arbovirus connu activement transmis par ces moustiques est o'nyong-nyong (ONNV). Le potentiel vectoriel des anophèles pour la transmission virale est peu connu. Cependant, la présence d’arbovirus chez ces moustiques indique une possibilité pour les anophèles de devenir des vecteurs viraux plus importants à l'avenir. La réponse antivirale chez ces moustiques a été principalement étudiée avec ONNV, bien que peu d'information soit disponible sur le sujet. Les « Ras-GAP SH3 domain-binding protein » (G3BP) et leur orthologue, Rasputin, chez le moustique ont été très étudiés chez les mammifères et seulement explorés chez les moustiques Aedes en tant que facteurs proviraux. Cependant, le rôle de Rasputin chez les anophèles et le mécanisme moléculaire proviral exact médié par Rasputin et les G3BPs n’est pas connu. Par conséquent, le premier objectif de cette thèse est d'évaluer le rôle de Rasputin lors de l'infection de ONNV chez les moustiques anophèles en se concentrant sur la modulation de l’immunité antivirale. En utilisant une combinaison de méthodes génomiques, microscopiques et biochimiques, j'ai prouvé, pour la première fois, que Rasputin agit via un nouveau mécanisme de détournement viral médié par son interaction avec la protéine virale non structurale 3 (nsP3) de ONNV. Rasputin agit comme l’interrupteur entre une immunité stérile et une infection virale au cours de la première phase d'infection de l’abdomen chez les moustiques.La deuxième partie de mon projet de thèse se concentre sur les facteurs déterminants la spécificité vectorielle chez les moustiques en utilisant ONNV et CHIKV comme modèle expérimental. ONNV et CHIKV sont deux alphavirus étroitement apparentés avec de nombreuses similitudes dans leur biologie, la seule différence connue entre ces deux virus est leur transmission par deux genres de moustiques différents. Des études ont révélé que nsP3 pourrait être un déterminant de la spécificité vectorielle entre ces deux virus, par conséquent nous évaluons le rôle de l'interaction entre Rasputin et nsP3 dans ce processus. En utilisant différentes méthodes génomiques et cellulaires, j'ai mis en évidence que Rasputin agit comme facteur proviral de CHIKV chez les anophèles. J'ai également montré que l'interaction entre Rasputin et nsP3 est en partie dépendant de l’origine virale du domaine hypervariable de nsP3. J’ai pu mettre en évidence que cette interaction pourrait jouer un rôle, au moins partiel, dans la spécificité vectorielle. Enfin, j'ai étudié le rôle d'un nouveau facteur impliqué dans l'infection de ONNV codé par le gène AGAP000570. J'ai montré que ce facteur extracellulaire a un rôle proviral au cours de l'infection d’ONNV via un possible mécanisme paracrine. J'ai également étudié la relation entre ce facteur proviral et Rasputin lors d'une infection virale révélant que ces deux protéines pourraient agir dans la même voie et qu’elles peuvent réguler leurs expressions transcriptionnelles entre elles. Ces résultats génèrent de nouvelles informations biologiques sur la fonction provirale de Rasputin dans la manipulation des voies immunitaires antivirales chez les moustiques qui pourraient être étendues au rôle de l'orthologue G3BP chez les mammifères
Aedes aegypti mosquitoes are vectors of many arboviruses including chikungunya virus (CHIKV), Dengue virus, yellow fever virus, and Zika virus. In contrast Anopheles gambiae transmit the parasite Plasmodium, causative agent of malaria. The response of Anopheles mosquitoes to pathogens has been studied mainly for Plasmodium due to the clinical importance of malaria. The only known arbovirus for which Anopheles is the primary vector is o’nyong-nyong virus (ONNV). It is not understood why Anopheles apparently do not display more vectorial potential for arboviruses, particularly because the presence of a virome and transmission of ONNV suggests a potential risk for Anopheles to become a more prominent arbovirus vector in the future. Antiviral response in Anopheles has primarily been studied using ONNV, although only relatively few reports have been published on the subject. The mosquito orthologs of Ras-GAP SH3 domain binding proteins (G3BP), called Rasputin, has been studied in mammals but barely examined in mosquitoes where Rasputin was shown to act as a proviral factor in Aedes, but the proviral molecular mechanism is not understood yet. The first objective of this thesis is to assess the role of Rasputin during ONNV infection in Anopheles mosquitoes and to determine the mechanism mediated by Rasputin. We hypothesis that Rasputin may interact with host antiviral immunity. By using a combination of genomic, cellular, and biochemical methods, I provide evidence that Rasputin is proviral because of the viral manipulation of Rasputin to modulate antiviral immune signaling pathways. These results indicate, for the first time, that Rasputin is required for viral hijacking as a physical target of the viral non-structural protein 3 (nsP3) of ONNV. The second part of my thesis project focused on vectorial specificity in mosquitoes by using the comparison of two closely related alphaviruses, ONNV and CHIKV, as an experimental model. ONNV and CHIKV display many similarities in their biology and pathology, with the major difference being their use of vector species (Anopheles and Aedes, respectively). Previous evidence suggested that nsP3 could be a determinant of vectorial specificity between those two viruses, and here we hypothesize that the role of the interaction between Rasputin and nsP3 of the two different viruses and mosquitoes has a role in vector specificity. By using genomic and cellular methods, I highlighted that Rasputin also acts as a proviral factor for CHIKV in an Anopheles cellular model. Moreover, we found that the match between Anopheles or Aedes Rasputin and the nsP3 of each virus is an important determinant of the cell-specific viral infection. Thus, the interaction between Rasputin and nsP3 of CHIKV and ONNV at least in part influences vectorial specificity for these alphaviruses. Finally, I studied the role of a new host factor involved in ONNV infection of Anopheles encoded by the gene AGAP000570. I characterized the proviral role of this extracellular factor during ONNV infection through a possible paracrine-like mechanism. I also assess the relationship between this secreted factor and Rasputin during viral infection and revealed that those two proteins could act in the same functional pathway. These results generate novel biological insight for the proviral function of Rasputin in manipulating antiviral immune pathways in mosquitoes that could be extended to the role of G3BP in mammals

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Chen, Weiqiang. „The Interplay between Alphaviral Infection and Inflammatory Arthritis“. Thesis, Griffith University, 2015. http://hdl.handle.net/10072/367986.

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Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya (CHIKV), Sindbis-like viruses (SINV), Barmah Forest virus (BFV), ) Mayaro virus (MAYV) and o’nyong-nyong virus (ONNV) are responsible for outbreaks of debilitating rheumatic joint disease during infection. CHIKV is typically notorious in central Africa, India, South-East Asia and Europe, while other alphaviruses such as RRV and BFV are endemic to Australia. In Australia, there are approximately 4000 cases of RRV reported annually, while the number of CHIKV cases continues to rise in epidemic regions. In 2014, CHIKV invaded several Caribbean islands in the Americas, with a current estimated 1.1 million autochthonous transmission cases as of 16th January 2015. During disease outbreak, more than 95% of patients experience intense persisting pain, generally in knees and the joints of extremeties. Despite the high occurrence rheumatic joint symptoms during alphavirus infection, there are limited studies on the skeletal pathologies due to the lack of routine clinical surveillance. Hence, very little is known about the impact of alphavirus infection on the bone remodelling process and warrants further investigation.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Science, Environment, Engineering and Technology
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Paulo, Luciana Batista de. „Complexos de cobre (II) com bases de Schiff tridentadas, tipo ONN e tetradentadas simétricas e assimétricas, tipo ONNO: síntese e caracterização e estudos como catalisadores na oxidação de catecóis“. Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/6487.

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Salen-type complexes are an important class of coordination compounds and are used as catalysts in various homogeneous and heterogeneous systems. Complexes of transition metals participate in many chemical processes, which make the study of these complexes very interesting. Research shows that the complexes of salen [salen = N, N'-ethylenebis (salicilidenoamina)] are efficient catalysts. Some compounds of this type have been investigated as catalysts for the oxidation of catechol. In this work three types of compounds the tetradentate ligands and symmetrical complexes, tridentate complexes and the asymmetric tetradentate complex, were synthesized. The series provided satisfactory yields. The compounds synthesized in this work were characterized by melting point, elemental analysis, vibrational spectroscopy in the IR region, absorption spectra in the UV-vis, conductivity measurements and solubility. The ligands were also characterized by nuclear magnetic resonance. From these characterizations, comparisons were made with respect to the effects of the substituents on the aromatic ring within the same series of compounds and also compared the results obtained for different lines of work. The kinetics was performed using a spectrophotometer, following the formation of the product derived from oxidation of 3,5-di-tert-butylcatechol at 400 nm. Among the complexes showed catalytic activity are the symmetrical complex [Cu (salen)], kcat = 2.6 x10-2 s-1, Vmax = 1.74 x10-7 mol L-1 s-1 and the complex asymmetric [Cu (3.5 Brsalen)]ass, kcat = 4.1 x10-2s-1, Vmax = 2.72 x10-7 mol L-1 s-1 and [Cu (3.5 Br4MeO-3, 5Br'salen) ]ass, kcat = 5.2 x10-2 s-1, Vmax = 3.39 x10-7 mol L-1 s-1.
Os complexos do tipo salen são uma classe importante dos compostos de coordenação e são utilizados como catalisadores em vários sistemas homogêneos e heterogêneos. Complexos de metais de transição têm participação em muitos processos químicos, o que torna o estudo desses muito interessantes. Pesquisas mostram que os complexos de salen [salen= N,N -etilenobis(salicilidenoamina)] são catalisadores eficientes. Alguns compostos deste tipo foram investigados como catalisadores na oxidação de catecol. Foram sintetizados nesse trabalho três tipos de compostos, os ligantes e complexos tetradentados simétricos; os complexos tridentados; e os complexos tetradentados assimétricos. As séries apresentaram rendimentos satisfatórios. Os compostos sintetizados nesse trabalho foram caracterizados por ponto de fusão, análise elementar, espectroscopia vibracional na região do IV, espectroscopia de absorção na região do UV-vis, medidas de condutividade e solubilidade. Os ligantes foram caracterizados também por Ressonância Magnética Nuclear. A partir dessas caracterizações, foram feitas comparações com respeito aos efeitos dos substituintes no anel aromático dentro de uma mesma série de compostos e também foram comparados os resultados obtidos para as diferentes séries do trabalho. A cinética foi realizada em um espectrofotômetro, acompanhando-se a formação do produto derivado da oxidação do 3,5-di-terc-Butilcatecol em 400 nm. Dentre os complexos que apresentaram atividade catalítica estão o complexo simétrico [Cu(salen)], kcat = 2,6x10-2 s-1, Vmax=1,74x10-7 mol L-1 s-1 e os complexos assimétricos, [Cu(3,5Brsalen)], kcat = 4,1x10-2s-1, Vmax=2,72x10-7mol-1 L-1 s-1 e [Cu(3,5Br4MeO-3,5Br salen)], kcat = 5,2x10-2 s-1, Vmax=3,39x10-7 mol L-1 s-1.

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Silva, Ricardo Soares Mota. „Complexos mono, bi e trinucleares de metais de transição com bases de Schiff tridentadas tipo ONN e tetradentadas do tipo ONNO : síntese, caracterização e estudos como catalisadores na oxidação de catecois“. Universidade Federal de São Carlos, 2015. https://repositorio.ufscar.br/handle/ufscar/7311.

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Salen-type complexes are an important class of coordination compounds, which have been used to catalyze a wide variety of reactions in various homogeneous and heterogeneous systems. Complexes of transition metals are very versatile and participate in many chemical processes, which make the study of these very interesting. Research shows that the complexes of salen [salen = N, N'-ethylenebis (salicilidenoamina)] are efficient catalysts, and some compounds of this type have been investigated as catalysts in the oxidation of catechol. In this work were synthesized six types of compounds, ligands, symmetric mononuclear complexes, tridentate complexes, asymmetric mononuclear complexes, binuclear and trinuclear complexes. The series have satisfactory yields. The synthesized compounds in this work were characterized by melting point, elemental analysis, vibrational spectroscopy in the IR region, absorption spectra in the UV-vis, conductivity measurements and solubility. The ligands and three palladium(II) complexes were also characterized by nuclear magnetic resonance. From these characterizations, comparisons were made between ligands, mononuclear, tridentate, binuclear and trinuclear complexes, and also with respect to the effects of the substituents on the aromatic ring at positions 4 and 5. The kinetics was performed using a spectrophotometer, following the formation of the product derived from oxidation of 3,5-di-tert-butylcatechol at 400 nm. In kinetic study were tested the binuclear and the trinuclear complexes which showed catalytic activities compatible with those of similar complexes described in the literature, among them we can mention the binuclear complexes [Cu(Cu(t-4DEA-salcn))Cl2] e [Cu(Cu(t-5NO2- salcn))Cl2] , kcat = 0,132 s-1 e kcat = 0,108 s-1, respectively; and the palladium(II) copper(II) binuclear complexes [Cu(Pd(t-salcn))Cl2] e [Cu(Pd(t-4-DEA-salcn))Cl2], kcat = 0,113 s-1 e kcat = 0,240 s-1, respectively.
Salen complexos são uma importante classe de compostos de coordenação, os quais vêm sendo usados para catalisar uma larga variedade de reações em vários sistemas homogêneos e heterogêneos. Complexos de metais de transição são muito versáteis e tem participação em muitos processos químicos, o que torna o estudo desses muito interessantes. Pesquisas mostram que os complexos de salen [salen= N,N’-etilenobis(salicilidenoamina)] são catalisadores eficientes, sendo que, alguns compostos deste tipo foram investigados como catalisadores na oxidação de catecois. Foram sintetizados nesse trabalho seis tipos de compostos: ligantes, complexos mononucleares simétricos, complexos com ligantes tridentados, complexos mononucleares assimétricos, complexos binucleares e um complexo trinuclear. As séries apresentaram rendimentos satisfatórios. Os compostos sintetizados nesse trabalho foram caracterizados por ponto de fusão, análise elementar, espectroscopia vibracional na região do IV, espectroscopia de absorção na região do UV-vis, medidas de condutividade e solubilidades, sendo os ligantes e três complexos de paládio(II) também caracterizados por Ressonância Magnética Nuclear. A partir dessas caracterizações, foram feitas comparações entre ligantes, complexos tridentados, complexos mononucleares, binucleares e trinuclear, e também com respeito aos efeitos dos substituintes no anel aromático 4 e 5. As cinéticas foram estudadas por meio espectrofotométrico acoplado a banho termostatizado acompanhando-se a formação do produto derivado da oxidação do 3,5-di-terc-Butilcatecol em 400 nm. No estudo cinético foram testados os complexos binucleares e o trinuclear os quais apresentaram atividades catalíticas compatíveis com as de complexos similares descritos na literatura. Dentre estes podemos citar os complexos binucleares simétricos [Cu(Cu(t-4DEA-salcn))Cl2] e [Cu(Cu(t-5NO2- salcn))Cl2] , kcat = 0,132 s-1 e kcat = 0,108 s-1, respectivamente; e os complexos binucleares paládio(II) cobre(II) [Cu(Pd(t-salcn))Cl2] e [Cu(Pd(t-4-DEA-salcn))Cl2], kcat = 0,113 s-1 e kcat = 0,240 s-1, respectivamente.

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Kortmann, Onno [Verfasser]. „Scintillator performance investigation for MSL, RAD / Onno Kortmann“. Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1020003731/34.

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Mais, Carla <1992&gt. „Onna bugeisha La donna guerriera tra realtà storica e tradizione inventata“. Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/14609.

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L’immagine collettiva che si ha del “samurai” è quella del guerriero maschio al servizio del proprio signore, fedele sino alla morte e pronto a dare la sua vita per proteggere il suo onore. Questa immagine si è formata tramite l’influenza di numerose cronache storiche, diari e racconti di guerra che ci sono pervenuti intatti fino ad oggi, ma è in parte anche stata costruita nel processo di “invenzione della tradizione” che ha accompagnato la costruzione dell’identità nazionale giapponese. Tuttavia, le fonti storiche menzionano anche donne samurai, le cosiddette onna bugeisha. Questo elaborato si propone di descrivere e analizzare la figura di queste donne guerriere, ricostruendo sia la loro evoluzione storica, sia l’immaginario a esse associato. Nella prima parte della tesi, una ricostruzione storico-cronologica descriverà l’evoluzione del ruolo della donna guerriera in rapporto al suo contesto sociale. Si presenteranno poi i casi di studio di alcune figure femminili guerriere vissute nei diversi periodi storici, concentrandosi soprattutto sui periodi Kamakura e Sengoku. Nell’ultima parte, si cercherà di delineare le motivazioni per cui la storiografia contemporanea ha avuto un maggiore disinteresse nel documentare le gesta delle donne guerriere, tanto da renderle oggi quasi completamente sconosciute, rispetto alla fiorente documentazione sulla loro controparte maschile.

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Tapia, León Onno [Verfasser]. „Einfluss von chronischem und akutem Stress auf appetitive Konditionierung / Onno Tapia León“. Gießen : Universitätsbibliothek, 2018. http://d-nb.info/1173614958/34.

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Martens, Onno [Verfasser], und Walter [Akademischer Betreuer] Schumacher. „Bewertung und Analyse des Regelverhaltens laufzeitoptimierter Mehrachsregelsysteme / Onno Martens ; Betreuer: Walter Schumacher“. Braunschweig : Technische Universität Braunschweig, 2017. http://d-nb.info/1175817848/34.

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Kleen, Onno [Verfasser], und Christian [Akademischer Betreuer] Conrad. „Three Essays on Volatility Forecasting and Forecast Evaluation / Onno Kleen ; Betreuer: Christian Conrad“. Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1215187580/34.

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Rizzatello, Alex <1991&gt. „Onna no yobahi. Il corteggiamento delle donne in Giappone dal periodo Nara al periodo Heian“. Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/9879.

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La ricerca sulle usanze maritali mira a illustrare che nell’antichità, e in particolare nei periodi pre-Nara (fino al 710), Nara (710-784) e Heian (794-1185), la donna non era semplicemente una figura passiva che attendeva la visita dell’amato (nota con l’espressione giapponese matsu onna, letteralmente “donna che aspetta”), ma, al contrario, godeva di un certo grado di libertà nelle relazioni amorose che le permetteva di “dare la caccia” all’uomo per cui provava interesse. Tale pratica prende il nome di onna no yobahi. L’indagine si basa principalmente sugli studi condotti da Nishimura Tōru, Ōchōbito no koi (2003), e da Ding Li, Ise monogari to sono shūen: jendaa no shiten kara (2006), che ad oggi rappresentano le uniche due ricerche di valore su questo tema. Se, da un lato, la scarsità di studi in questo campo è stata un grande incentivo a ricercare quanti più esempi possibili nella letteratura di questi periodi, dall’altro ha reso necessaria un’attività di analisi della condizione della donna in questi periodi storici che aiutasse a sostenere la teoria sopra esposta. Il lavoro è stato perciò sviluppato seguendo una struttura parallela: all’analisi storico-sociale della donna segue l’analisi dei testi, che, data la limitata lunghezza dell’elaborato, si concentrerà in particolare su tre opere: Kojiki (Un racconto di antichi eventi, 712), Man’yōshū (Raccolta delle diecimila foglie, 759), e Ise monogatari (Storie di Ise, metà del X secolo). Nel primo capitolo si analizzerà la posizione della donna nei periodi pre-Nara e Nara e si discuterà del rapporto tra uomini e donne, a partire dagli incontri definiti utagaki, festività che, attraverso lo scambio di poesie, servivano a trovare un partner, per arrivare alle relazioni matrimoniali, probabile riflesso di una società matriarcale. Infine sarà condotta una breve analisi sulla terminologia impiegata nelle relazioni tra uomo e donna che ricorrerà durante la trattazione dei testi. Nel secondo capitolo si prenderanno in esame alcuni passi tratti dal Kojiki, tra cui il rapporto sessuale tra le divinità creatrici delle isole giapponesi, Izanagi e Izanami, e la poesia del dio Ōkuninushi, considerata il primo esempio di corteggiamento nella letteratura giapponese. In seguito, attraverso alcune poesie del Man’yōshū risalenti ai primi due periodi di produzione (629-710), si spiegheranno le varie forme di corteggiamento di entrambi i sessi, a partire dall’invio di una poesia, sino ad arrivare al travestimento e all’inganno. Parallelamente saranno analizzate la figura della matsu onna e del matsu otoko, l’uomo che attende l’arrivo dell’amata. Nel terzo capitolo si dimostrerà come il regno dell’imperatrice Kōken sia stato determinante nel plasmare la condizione femminile del successivo periodo Heian, “relegando” le donne a una posizione di inferiorità rispetto agli uomini, nonostante prestassero servizio a corte e facessero parte dell’entourage dell’imperatore, ma che, comunque, avevano ancora un ruolo fondamentale nell'istituzione matrimoniale. Nel quarto capitolo, infine, attraverso la traduzione e l’analisi di alcuni passi dell’Ise monogatari, si tenterà di delineare le caratteristiche dei rapporti tra uomo e donna, ponendo particolare attenzione sul fatto che a quest’ultima, nonostante i tempi fossero cambiati, non era comunque impedito di prendere l’iniziativa e corteggiare un uomo. le ricerche sul ruolo della donna in Giappone fino al periodo Heian rappresentano tanti tasselli di uno stesso puzzle che raffigura una donna forte e indipendente, che non ha bisogno dell’appoggio di un uomo per vivere. Rielaborando i dati raccolti in queste indagini e proponendo una nuova chiave di lettura dei testi classici, si tenterà di aggiungere un ulteriore tassello dimostrando che la donna era libera di intraprendere relazioni amorose.

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Bücher zum Thema "ONNV"

Onna. Tōkyō: Sanseidō, 1997.

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Endō, Shūsaku. Onna. Tōkyō: Kōdansha, 1995.

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Yomitoki Genji Monogatari: Kiritsubo no maki no hikari to kage. Tōkyō: Meiji Shoin, 2009.

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Nishihara, Shiho. "Genji monogatari" Onna Sannomiya no "naimen". Tōkyō: Kabushiki Kaisha Shintensha, 2017.

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Edo no onna, ima no onna. Fukuoka-shi: Ashi Shobō, 1994.

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Yukichi, Fukuzawa. Onna daigaku hyōron, shin onna daigaku. Tōkyō: Kōdansha, 2001.

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Onna no kunshō: Meiji onna no ikizama. Fukuoka-shi: Ashi Shobō, 1991.

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Ōya, Masako. Onna wa dokyō: Onna wa naitara akimahen! Tōkyō: Rongu Serāzu, 1987.

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Shiryōka, Kokuritsu Gekijō Chōsa. Tōshi kyōgen Imoseyama onna teikin. Tōkyō: Nihon Geijutsu Bunka Shinkōkai, 2004.

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Shiryōka, Kokuritsu Gekijō Chōsa. Imoseyama onna teikin. Tōkyō: Nihon Geijutsu Bunka Shinkōkai, 2001.

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Buchteile zum Thema "ONNV"

Naumann, Nelly. „Arishima Takeo: Aru onna“. In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2093-1.

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Schnellbächer, Thomas. „Abe Kōbō: Suna no onna“. In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2082-1.

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Hammitzsch, Horst. „Ihara Saikaku: Kōshoku gonin onna“. In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2160-1.

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Hammitzsch, Horst. „Ihara Saikaku: Kōshoku ichidai onna“. In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2161-1.

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Wang, Liang, und Jianxin Zhao. „Compiler Backends“. In Architecture of Advanced Numerical Analysis Systems, 215–28. Berkeley, CA: Apress, 2022. http://dx.doi.org/10.1007/978-1-4842-8853-5_8.

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AbstractFor a numerical library, it is always beneficial and challenging to extend to multiple execution backends. We have seen how we support accelerators such as the GPU by utilizing a symbolic representation and computation graph standard such as ONNX. In this chapter, we introduce how Owl can be used on more edge-oriented backends, including JavaScript and unikernel.

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Geetha, B. „Ellā Manusanum inga onnu illa 1“. In The Routledge Companion to Caste and Cinema in India, 387–401. London: Routledge India, 2022. http://dx.doi.org/10.4324/9781003343578-39.

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Schomburg, Dietmar, und Dörte Stephan. „Methyl-ONN-azoxymethanol beta-D-glucosyltransferase“. In Enzyme Handbook 12, 783–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_171.

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Bujarrabal, Valentín. „Molecular Data onn Circum-Stellar Envelopes Around AGB Stars“. In Mass-Losing Pulsating Stars and their Circumstellar Matter, 275–82. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-010-0139-7_65.

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D’Amico, Gianpaolo, Alberto Del Bimbo, Andrea Ferracani, Lea Landucci und Daniele Pezzatini. „Onna Project: A Natural Interaction Installation and Mobile Solution for Cultural Heritage“. In Built Heritage: Monitoring Conservation Management, 359–65. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-08533-3_30.

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Pardasani, R. T., und P. Pardasani. „Magnetic properties of dinuclear cobalt(II) complex with ONNO donor azo dye“. In Magnetic Properties of Paramagnetic Compounds, 1233. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_727.

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Konferenzberichte zum Thema "ONNV"

Lin, Wei-Fen, Der-Yu Tsai, Luba Tang, Cheng-Tao Hsieh, Cheng-Yi Chou, Ping-Hao Chang und Luis Hsu. „ONNC: A Compilation Framework Connecting ONNX to Proprietary Deep Learning Accelerators“. In 2019 IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS). IEEE, 2019. http://dx.doi.org/10.1109/aicas.2019.8771510.

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Abernot, Madeleine, Sylvain Gauthier, Theophile Gonos und Aida Todri-Sanial. „SIFT-ONN: SIFT Feature Detection Algorithm Employing ONNs for Edge Detection“. In NICE 2023: Neuro-Inspired Computational Elements Conference. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3584954.3584999.

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Yu, Francis T. S., Xiang Y. Yang, Wade Reeser, Kenji Matsushita und Don A. Gregory. „Polychromatic neural network“. In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/oam.1991.tuk4.

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We have recently proposed and demonstrated optical neural networks (ONNs) with liquid crystal televisions (LCTVs), in which usually color LCTVs are used.1,2 Since each color pixel is composed of red, green, and blue elements, the resolution is reduced. However, the color LCTVs offer the capability of storing and processing color information. A polychromatic ONN is presented in this paper. In the training phase, the color images are decomposed into three primary colors. The monochrome interconnection weight matrices (IWMs) are constructed based on three independent training sets in primary colors. The polychromatic IWM is then composed and displayed on the LCTV for the reconstruction of the stored color patterns.

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Yu, Francis T. S., Xiang Y. Yang, Shudong Wu, Suganda Jutamulia, George M. Storti und Joseph Lindmayer. „Optical neural network using novel electron trapping materials“. In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/oam.1991.mv3.

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Massive interconnection is one of the key features of artificial neural networks, which can be implemented optically by encoding the interconnection weight matrix (IWM) on a spatial light modulator (SLM) and superimposing all the IWM-submatrix with a lenslet array. The low dynamic range and very limited resolution of the currently available SLMs are the main concern for the development of optical neural network (ONN). So far the largest ONNs with lenslet array contain only 64 neurons and 4096 interconnections,1,2 which can have little practical use. However, the weakness can be effectively strengthened by a novel electron trapping (ET) material that has a resolution of ~100 lines/mm, dynamic range of 4 orders of magnitude, and is suitable for a 3-D interconnection implementation. An ONN architecture with 128 × 128 neurons is proposed in this paper. The massive interconnections are stored in 100 layers of ET thin film. The page-addressable 3-D ET memory offers a huge information capacity and may have vast uses in real-time target tracking and pattern recognition. The proposed system can store a total of 2.7 × 1010 interconnections and have a processing speed as high as 5.4 × 1011 interconnections per second. System design considerations as well as performance evaluations are provided.

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„OnAV Organizers“. In 2008 International Conference on Complex, Intelligent and Software Intensive Systems. IEEE, 2008. http://dx.doi.org/10.1109/cisis.2008.180.

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„OnAV Reviewers“. In 2008 International Conference on Complex, Intelligent and Software Intensive Systems. IEEE, 2008. http://dx.doi.org/10.1109/cisis.2008.181.

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„OnAV 2009 Workshop Reviewers“. In 2009 International Conference on Complex, Intelligent and Software Intensive Systems. IEEE, 2009. http://dx.doi.org/10.1109/cisis.2009.220.

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„Reviewers OnAV 2010 Workshop“. In Fourth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2010). IEEE, 2010. http://dx.doi.org/10.1109/cisis.2010.223.

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„OnAV 2009 Workshop Welcome Message“. In 2009 International Conference on Complex, Intelligent and Software Intensive Systems. IEEE, 2009. http://dx.doi.org/10.1109/cisis.2009.218.

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„OnAV 2009 Workshop Organizing Committee“. In 2009 International Conference on Complex, Intelligent and Software Intensive Systems. IEEE, 2009. http://dx.doi.org/10.1109/cisis.2009.219.

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Berichte der Organisationen zum Thema "ONNV"

Ball, J., P. Chesny und M. Combet. Measurements of the D{sub onon} and K{sub onno} observables in np elastic scattering between 0.80 and 1.10 GeV. Office of Scientific and Technical Information (OSTI), März 1993. http://dx.doi.org/10.2172/207471.

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