Dissertationen zum Thema „Oncogene Protein p21(ras)“
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Iritani, Brian Masao. „Control of B lymphocyte development by Ras and Raf /“. Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8322.
Der volle Inhalt der QuelleBradbury, Andrew W. „Cyclic AMP binding proteins and ras p21 oncogene expression in human colorectal cancer and mucosa“. Thesis, University of Edinburgh, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531024.
Der volle Inhalt der QuelleEstrozi, Bruna. „Avaliação anatomoclínica e molecular do melanoma cutâneo em pacientes jovens (idade 18-30 anos)“. Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-01042015-144721/.
Der volle Inhalt der QuelleThe incidence of cutaneous melanoma in young adults has dramatically increased in recent years. However, there is scarce data about the clinicopathological and molecular characteristics on the melanomas occurring at this age group. The present study aimed to evaluate 132 patients aged between 18 and 30 years with primary cutaneous melanoma with emphasis on the study of clinical, histopathological characteristics and molecular evaluation of mutations in BRAF, NRAS and KIT genes. Regarding the clinical and histopathological findings, the following results were found: female predominance (61.4%), trunk was the most commonly anatomical site involved (44.3%) and superficial spreading melanoma, was the most common histological type (79.5 %). The V600E mutation in BRAF (BRAFV600E) gene was analyzed in 93 cases, using RT-PCR. It was present in 38.7% (36/93) and statistically related to the vertical growth phase (p = 0.01), mild inflammatory infiltration (p = 0.02) and the presence of intradermal mitosis (p = 0.004). There was, also, strongly evidence of an association with the presence of ulceration (p = 0.05). Worse prognosis was associated with these variables. There was a predominance of BRAFV600E mutation in anatomical regions related to intermittent sun exposure. No cases of melanoma with BRAFV600E mutation showed regression phenomenon (p < 0.05). There was no significant association between BRAFV600E and gender, histological type, Clark level, Breslow thickness, solar elastosis, angiolymphatic and perineural invasion, sattelitosis, coexisting melanocytic nevus and survival. The presence of a mutation in NRAS, by RT-PCR was seen in 3.95% (3/76) of the cases. All these three mutations were of type 61K, occurred in male patients and the head and neck region. BRAFV600E and NRAS mutations, when present, were mutually exclusive. The frequency of KIT mutations, analyzed by sequencing, was 11.1% (3/27). The three mutations identified in this gene were located in exon 9 (G510, G498S and 489I). Concomitant mutations were found between KIT and NRAS and BRAFV600E. Due to the small number of KIT and NRAS mutated cases, it was not possible to establish clinical and histopathological correlations and mutation status in these genes. This study was the first to describe the G510D and G498S mutations in KIT gene in cutaneous melanomas. In the present study, BRAFV600E mutation in cutaneous melanoma of young adults correlated with anatomic and clinical features of worse prognosis compared to wild type
Filho, João Bosco de Oliveira. „Mutação em NRAS causa uma síndrome autoimune linfoproliferativa humana“. Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-04112008-174252/.
Der volle Inhalt der QuelleThe p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leading to Noonan, cardio-facial-cutaneous and Costello syndrome, but activating germline mutations of NRAS have not been reported. Autoimmune lymphoproliferative syndrome (ALPS) is the most common genetic disease of lymphocyte apoptosis and causes autoimmunity as well as excessive lymphocyte accumulation, particularly of CD4-, CD8- ab T cells. Mutations in ALPS typically affect Fas-mediated apoptosis, but certain ALPS individuals have no such mutations. We show here that the salient features of ALPS as well as a predisposition to hematological malignancies can be caused by a heterozygous germline Gly13Asp activating mutation of the NRAS oncogene that does not impair Fas-mediated apoptosis. The increase in active, GTP-bound NRAS augmented RAF/MEK/ERK signaling which markedly decreased the pro-apoptotic protein BIM and attenuated intrinsic, nonreceptor-mediated mitochondrial apoptosis. Thus, germline activating mutations in NRAS differ from other p21 Ras oncoproteins by causing selective immune abnormalities without general developmental defects
Driscoll, David R. „The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation“. eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/821.
Der volle Inhalt der QuelleDriscoll, David R. „The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation“. eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/821.
Der volle Inhalt der QuelleMartins, Carla Pedro. „Cip/Kip proteins in the suppression of murine lymphomagenesis“. [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/67628.
Der volle Inhalt der QuelleAlexandre, Cristianne da Silva. „As células linhagem negativa (Lin) de medula óssea atenuam a progressão da doença renal crônica“. Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-10032008-150329/.
Der volle Inhalt der QuelleProgressive renal failure continues to be a challenge. The use of bone marrowderived stem cells (SCs) represents a means of meeting that challenge. We used lineage-negative (Lin-) SCs to test the hypothesis that Lin- cell infusion decreases renal injury. Syngeneic Fischer 344 rats were submitted to 5/6 nephrectomy and divided into 3 groups: Nx (untreated); NxSC1 (receiving 2 × 106 Lin- cells on postnephrectomy day 15); and NxSC3 (receiving 2 × 106 Lin- cells on postnephrectomy days 15, 30 and 45). Controls were unoperated/untreated. On postnephrectomy day 60, clearance studies, immunohistochemistry and immunoblotting were performed. Lin- cell infusion effectively reduced postnephrectomy proteinuria, glomerulosclerosis, anemia, renal infiltration of immune cells and monocyte chemoattractant protein-1 protein expression, as well as decreasing the interstitial area. Immunostaining for proliferating cell nuclear antigen showed that, in comparison with controls, Nx rats presented greater cell proliferation, whereas NxSC1 rats and NxSC3 rats presented less cell proliferation than did Nx rats. Protein expression of p21 and VEGF increased after nephrectomy and decreased after Lin- cell infusion. Protein expression of eNOS reduced after nephrectomy and increased after cell infusion. These data suggest that SC treatment ameliorates progressive end-stage renal disease.
Golbert, Lenara. „Implicações do aumento da expressão do proto-oncogene Ras no bócio multinodular“. reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/7815.
Der volle Inhalt der QuelleMultinodular goiter (MNG) is an enlargement of the thyroid gland and is characterized by heterogeneity in growth and function of thyroid follicular cells. It is a common pathology, with higher prevalence in iodine deficiency areas. Iodine deficiency is the main etiologic factor for MNG. MNG have been considered a true thyroid neoplasm. The pathogenesis of multinodular goiter is not yet clarified. The purpose of this review is to summarize the current knowledge of MNG with respect to the pathology, etiologic and clinical characteristics.
Benisty, Hannah 1986. „Post-transcriptional determinants of RAS protein abundance“. Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668206.
Der volle Inhalt der QuelleEls oncogens KRAS, NRAS i HRAS estan mutats en un terç dels càncers en humans on hi exhibeixen patrons de mutació diferents. Un possible factor que contribueix a aquest biaix de mutació és la variació dels nivells d'expressió de RAS. En aquesta tesi investigo els elements determinants de l'abundància de la proteïna RAS. Primer, examino si el biaix de codó entre els gens RAS i entre gens d'altres famílies implicades en càncer contribueix a les diferències d'expressió, en funció del context cel·lular. Així mateix, descric un programa d'expressió de tRNA que facilita la traducció d'oncogens en cèl·lules proliferatives. En segon lloc, investigo per què mutants oncogènics de RAS tenen una abundància de proteïna més elevada que la RAS salvatge. Així mateix, estudio els mecanismes subjacents responsables d'aquesta variació i més concretament el paper de les interaccions de RAS amb altres proteïnes en la regulació de la seva abundància. Així doncs, aquesta tesi estudia la possible rellevància dels mecanismes de síntesi i degradació de la proteïna RAS en els patrons de mutació en càncer.
Andeol, Yannick. „Contribution a l'etude des oncogenes cellulaires de la famille ras : caracterisation dans trois lignees tumorales humaines“. Paris 6, 1987. http://www.theses.fr/1987PA066065.
Der volle Inhalt der QuelleGendron, Louis. „Rôle du récepteur de type 2 de l'angiotensine II dans le développement neuronal des cellules NG108-15 : mécanismes d'action et implication de la voie p21 [ras en exposant]/MAPK (Mitogen/Microtubule-Activated Protein Kinase)“. Sherbrooke : Université de Sherbrooke, 2000.
Den vollen Inhalt der Quelle findenGendron, Louis. „Rôle du récepteur de type 2 de l'angiotensine II dans le développement neuronal des cellules NG108-15 mécanismes d'action et implication de la voie p21[ras en indice supérieur]/MAPK (Mitogen/Microtubule-Activated Protein Kinase)“. Mémoire, Université de Sherbrooke, 1999. http://savoirs.usherbrooke.ca/handle/11143/3210.
Der volle Inhalt der QuelleYasmin, Lubna. „Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3“. Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1411.
Der volle Inhalt der QuelleRestall, Ian J. „Inducing Cellular Senescence in Cancer“. Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23691.
Der volle Inhalt der QuelleGilkes, Daniele M. „Multiple modes of MDMX regulation affect p53 activation“. [Tampa, Fla.] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002312.
Der volle Inhalt der QuelleKumar, A., Mojgan Najafzadeh, B. K. Jacob, A. Dhawan und Diana Anderson. „Zinc oxide nanoparticles affect the expression of p53, Ras p21 and JNKs: an ex vivo/in vitro exposure study in respiratory disease patients“. 2015. http://hdl.handle.net/10454/9369.
Der volle Inhalt der QuelleZinc oxide (ZnO) nanoparticles are the mostly used engineered metal oxide nanoparticles in consumer products. This has increased the likelihood of human exposure to this engineered nanoparticle (ENPs) through different routes. At present, the majority of the studies concerning ZnO ENPs toxicity have been conducted using in vitro and in vivo systems. In this study, for the first time we assessed the effect of ZnO ENPs on the major cellular pathways in the lymphocytes of healthy individuals as well as in susceptible patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD) and asthma. Using the differential expression analysis, we observed a significant (P < 0.05) dose-dependent (10, 20 and 40 microg/ml for 6h) increase in the expression of tumour suppressor protein p53 (40, 60 and 110%); Ras p21 (30, 52 and 80%); c-Jun N-terminal kinases; JNKs) (28, 47 and 78%) in lung cancer patient samples treated with ZnO ENPs compared to healthy controls. A similar trend was also seen in COPD patient samples where a significant (P < 0.05) dose-dependent increase in the expression of tumour suppressor protein p53 (26, 45 and 84%), Ras p21 (21, 40 and 77%), JNKs (17, 32 and 69%) was observed after 6h of ZnO ENPs treatment at the aforesaid concentrations. However, the increase in the expression profile of tested protein was not significant in the asthma patients as compared to controls. Our results reiterate the concern about the safety of ZnO ENPs in consumer products and suggest the need for a complete risk assessment of any new ENPs before its use.
Reimann, Frank. „Der Einfluß von permanent aktivem Ras-Protein auf den Hippokampus bei p21-Ha-RasVal12-transgenen Mäusen /“. 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012924456&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Der volle Inhalt der QuelleLang, Ming-Jane, und 郎明蓁. „Expression of p21 ras, p53 protein and proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis“. Thesis, 1994. http://ndltd.ncl.edu.tw/handle/81230941583763931275.
Der volle Inhalt der Quelle國立臺灣大學
牙醫學研究所
82
In this study, we used immunohistochemical method to assess the expression of p21 ras, p53 and proliferating cell nuclear an- tigen (PCNA) in 50 cases of oral submucous fibrosis (OS F), 10 cases of normal oral mucosa, 10 cases of leukoplakia, 5 cases of epithelial dysplasia, and 5 cases of verrucous carcinoma. By statistic analysis, we further correlated the expression of p21 ras, p53 and PCNA in OSF with betel nut chewing, cigarette smoking, alcohol drinking as well as the depth of fibrosis and the degree of inflammation in subepithelial connective tissue. By immunohistochemistry, the positive staining of p21 ras was most often found in the cytoplasm and nuclei of epithelial cells of OSF oral mucosa. The pattern of p21 ras positive staining of OSFwas similar to that of normal oral mucosa. The positive staining of p53 was most frequently discovered in the nuclei of basal and suprabasal epithelial cells of OSF oral mucosa. The pattern of p53 positive staining of OSF was similar to those of leukoplakia and epithelial dysplasia. The positive staining of PCNA was most commonly noted in the nuclei of basal, suprabasal and lower spinous epithelial cells. The pattern of PCNA positive staining of OSF was very close to those of leukoplakia, epith- elial dysplasia, and verrucous carcinoma. The expression of p53 in the whole layer of epithelial cells of OSF oral mucosa was positively and significantly correlated to the duration of chew- ing betel nuts (P<0.05). There was a significant negative corre- lation between the expression of PCNA in the whole layer of epi- thelial cells of OSF oral mucosa and the total number of ciga- rettes smoked by the OSF patients (P<0.05). We concluded thatOSF was undoubtful an oral precancerous lesion, because the p53 and PCNA positive staining patterns of OSF were similar to those of oral leukoplakia and epithelial dysplasia.
Hong, Yi Ling, und 洪義玲. „Expression of EGF, TGF-∝, EGFR, p21 ras, p53 protein and proliferating cell nuclear antigen (PCNA) in ameloblastoma“. Thesis, 1995. http://ndltd.ncl.edu.tw/handle/98002949662313343198.
Der volle Inhalt der QuelleRuan, Kai Wen, und 阮凱文. „Expression of p53 protein, proliferating cell nuclear antigen (PCNA) and p21 ras in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma“. Thesis, 1996. http://ndltd.ncl.edu.tw/handle/68631544881517218086.
Der volle Inhalt der Quelle國立臺灣大學
牙醫科學研究所
84
We used the immunohistochemical method to study the expressions of p53 protein, PCNA and p21 ras in 30 cases of mucoepidermoid carcinoma (MEC), 37 cases of adenoid cystic carcinoma(ACC), 5 cases of normal submandibular gland and 7 cases of minor salivary gland adjacent to mucocele. The p53 positive staining rates were 66.7% and 70.3% for 30 MECs and 37 ACCs, respectively. Overexpression of p53 protein in MECs was significantly associated with advanced clinical staging (P<0.01) and perineural invasion(P<0.01), but not with histologic grading of malignancy.Expression of p53 protein in MECs of major salivary gland (MjMECs) was also significantly and positively correlated to clinical staging of cancer. The PCNA positive rates were both 100% for 30 MECs and 37 ACCs, and the mean PCNA indices were 59.8 .plmin.19.9% and 56.8 .plmin.20.7% for MECs and ACCs,respectively .High PCNA expression was found in MECs with deep invasion (P< 0.01) as well as in ACCs with perineural invasion (P<0.05) and cellular anaplasia (P<0.05). However, there was a significant negative correlation found between PCNA indices and MjMECs with lymph node metastasis(P<0.05) or with high grade malignancy (P< 0.05). Women tended to have higher PCNA expression in MECs in minor salivary gland (MiMECs) than men (P<0.01). The p21 ras positive staining rates were 76.7% for 30 MECs and 94.6% for 37 ACCs. High p21 ras expression in MECs was observed in cancers of low clinical staging (P<0.01), low grade malignancy (P<0.01), no deep invasion (P<0.001) and no lymph node metastasis (P<0.01). In MjMECs, low p21 ras expression was significantly associated with tumors with deep invasion (P<0.01) and high grade malignancy (P< 0.01). In MiMECs, high p21 ras expression tended to be more frequently seen in women than in men (P<0.01) and in tumors without deep invasion than tumors with deep invasion (P<0.01).
Stafford, Amy Jo. „Electrostatic fields at the functional interface of the protein Ral guanine nucleotide dissociation stimulator determined by vibrational Stark effect spectroscopy“. Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-12-4685.
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