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Dissertationen zum Thema „Olfactory circuit“

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1

Kohl, Johannes. "A sexually dimorphic circuit switch in higher olfactory centres." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/265572.

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In Drosophila the male sex pheromone cis-vaccenyl acetate (cVA) elicits different behaviours in males and females: while males are repelled by cVA, it stimulates female receptivity. However, olfactory receptor neurons and their second-order partners, the olfactory projection neurons, do not show significantly different physiological responses to cVA. Using in vivo whole-cell electrophysiology I have identified two distinct clusters of third-order olfactory neurons that are pheromone-responsive only in males or females, respectively. These clusters are present in both sexes and share a common i
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2

Ostrovsky, Aaron. "A sexually dimorphic olfactory circuit in the fruit fly, Drosophila melanogaster." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610165.

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3

Jayaraman, Vivek Winfree Erik Laurent Gilles. "Neural circuit dynamics and ensemble coding in the locust and fruit fly olfactory system /." Diss., Pasadena, Calif. : California Institute of Technology, 2007. http://resolver.caltech.edu/CaltechETD:etd-05192007-195030.

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4

DasGupta, Shamik. "Neural Circuit Analyses of the Olfactory System in Drosophila: Input to Output: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/438.

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This thesis focuses on several aspects of olfactory processing in Drosophila. In chapter I and II, I will discuss how odorants are encoded in the brain. In both insects and mammals, olfactory receptor neurons (ORNs) expressing the same odorant receptor gene converge onto the same glomerulus. This topographical organization segregates incoming odor information into combinatorial maps. One prominent theory suggests that insects and mammals discriminate odors based on these distinct combinatorial spatial codes. I tested the combinatorial coding hypothesis by engineering flies that have only one c
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5

Strutz, Antonia [Verfasser], Bill S. [Gutachter] Hansson, David G. [Gutachter] Heckel, and Martin Paul [Gutachter] Nawrot. "Odor Coding Strategies in the Drosophila Olfactory Circuit / Antonia Strutz ; Gutachter: Bill S. Hansson, David G. Heckel, Martin Paul Nawrot." Jena : Friedrich-Schiller-Universität Jena, 2013. http://d-nb.info/1177639386/34.

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6

Monnot, Pauline. "Rôle des interactions mécaniques entre tissus dans la mise en place du circuit olfactif du poisson-zèbre." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS113.

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Alors que les signaux biochimiques impliqués dans la croissance axonale et la migration neuronale sont largement étudiés, la contribution des signaux mécaniques dans la formation des circuits neuronaux reste peu explorée in vivo. Nous cherchons à étudier comment les forces mécaniques contribuent à la formation du circuit olfactif du poisson-zèbre. Ce circuit se développe durant la morphogénèse de la placode olfactive (PO), par le mouvement passif des corps cellulaires qui s’éloignent de l’extrémité de leurs axones. Mes travaux de thèse s’intéressent à la contribution mécanique de l’œil, qui se
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7

Liu, Wendy Wing-Heng. "Dissecting Olfactory Circuits in Drosophila." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11453.

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Drosophila is a simple and genetically tractable model system for studying neural circuits. This dissertation consists of two studies, with the broad goal of understanding sensory processing in neural circuits using Drosophila as a model system.
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8

Sanz, Diez Alvaro. "Functional study of mouse olfactory bulb inhibitory circuits." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ037/document.

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Les cellules periglomerulaires du bulbe olfactif conforment une population hétérogène avec des propriétés moléculaires, synaptiques, morphologiques et biophysiques diverses toujours étudiés de façon indépendante. Toutefois, cette diversité suggère que des groupes différents des cellules periglomerulaires pourraient avoir des rôles différents. Dans la première partie de ma thèse je cherche à associer, pour la première fois, différents marqueurs de la diversité des neurones periglomerulaires de façon à aider à comprendre les potentielles implications fonctionnelles que les cellules periglomerula
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9

Galili, Dana Shani. "Neural circuits mediating aversive olfactory conditioning in Drosophila." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-175429.

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For all animals it is highly advantageous to associate an environmental sensory stimulus with a reinforcing experience. During associative learning, the neural representation of the sensory stimulus (conditioned stimulus; CS) converges in time and location with that of the reinforcer (unconditioned stimulus; US). The CS is then affiliated with a predictive value, altering the animal’s response towards it in following exposures. In my PhD thesis I made use of olfactory aversive conditioning in Drosophila to ask where these two different stimuli are represented and how they are processed in the
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10

Burton, Shawn D. "Novel Cell Types and Circuits in the Mouse Main Olfactory Bulb." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/686.

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The mammalian olfactory system is strikingly shallow. While peripheral input in other sensory systems is sequentially processed by brainstem, midbrain, and thalamic nuclei before reaching primary sensory and associational cortices, olfactory input is processed by only a single region of the brain – the main olfactory bulb – before reaching higher cortical areas. A tremendous amount of neural processing is thus compressed within the main olfactory bulb, making this region of the brain uniquely well suited for investigating fundamental principles of neural processing. Currently, the identity and
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11

Lai, Sen-Lin. "Neural Diversity in the Drosophila Olfactory Circuitry: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/340.

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Different neurons and glial cells in the Drosophila olfactory circuitry have distinct functions in olfaction. The mechanisms to generate most of diverse neurons and glial cells in the olfactory circuitry remain unclear due to the incomprehensive study of cell lineages. To facilitate the analyses of cell lineages and neural diversity, two independent binary transcription systems were introduced into Drosophila to drive two different transgenes in different cells. A technique called ‘dual-expression-control MARCM’ (mosaic analysis with a repressible cell marker) was created by incorporating a GA
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12

Thum, Andreas Stephan. "Sugar reward learning in Drosophila neuronal circuits in Drosophila associative olfactory learning /." Doctoral thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980586771.

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13

Vieira, Inês. "Neural circuits of the mouse olfactory cortex : linking neural connectivity to behavior." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066543/document.

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Comment les odeurs contrôlent-elles le comportement animal ? Dans ma thèse, j'ai utilisé des manipulations optogénétiques et chimiogénétiques in vivo de l'activité neurale combinées à des analyses comportementales pour explorer l'organisation de circuits cérébraux impliqués dans des comportements olfactifs chez la souris. J'ai mis au point un test de conditionnement aversif olfactif indépendant de l'intensité des odeurs. J'ai démontré que les souris pouvaient généraliser une réponse aversive en présentant différentes concentrations d'odeurs. J’ai ensuite testé si les souris pouvaient apprendre
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14

Vanarse, Anup. "Interfacing of neuromorphic vision, auditory and olfactory sensors with digital neuromorphic circuits." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1802.

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The conventional Von Neumann architecture imposes strict constraints on the development of intelligent adaptive systems. The requirements of substantial computing power to process and analyse complex data make such an approach impractical to be used in implementing smart systems. Neuromorphic engineering has produced promising results in applications such as electronic sensing, networking architectures and complex data processing. This interdisciplinary field takes inspiration from neurobiological architecture and emulates these characteristics using analogue Very Large Scale Integration (VLSI
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15

Schmidt, Loren Janes. "OLFACTORY BULB SYNCHRONY: SPATIALLY LOCALIZED COINCIDENT INHIBITION OF MITRAL CELLS BY GABAERGIC MICROCIRCUITS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1404390871.

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16

Galili, Dana Shani [Verfasser], and Mark [Akademischer Betreuer] Huebener. "Neural circuits mediating aversive olfactory conditioning in Drosophila / Dana Shani Galili. Betreuer: Mark Huebener." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1060632594/34.

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17

Lorenzon, Paolo. "Ruolo dell'attività spontanea nella formazione dei circuiti neurali del bulbo olfattivo e nell' elaborazione dell'informazione sensoriale." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423442.

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The mammalian central nervous system relies on precise synaptic connections to function correctly. The development of precise neuronal circuitry is regulated by axon guidance molecules as well as by specific pattern of activity between the pre and the post synaptic elements. In this thesis I focused on activity dependent mechanisms, and we analyzed the role of spontaneous afferent activity in the topographic organization of the olfactory bulb. To address this point we analyzed the intrabulbar connections between isofunctional glomeruli in a line of mice genetically modified to have very li
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18

Hawkins, Sara Joy. "The timing of regeneration in the amphibian olfactory system." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15444.

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Mestrado em Biologia Molecular e Celular<br>Comprehending the mechanisms that make lifelong neurogenesis possible has a clear interest for the better understanding of the basic principles that govern cellular and molecular interactions in the nervous system, as well as a relevant clinical interest. The limited ability of the central nervous system to generate new neurons in order to replace those that have been lost is a formidable obstacle to recovery from neuronal damage caused by injury or neurodegenerative disease. The olfactory system (OS) is an ideal system to study the process of neuron
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19

Hovis, Kenneth Ray. "Analysis of Functional Circuitry and the Effect of Activity Across Development in the Mouse Accessory Olfactory System." Research Showcase @ CMU, 2011. http://repository.cmu.edu/dissertations/36.

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The vomeronasal system (VNS) is a chemosensory system designed for the detection of chemical messengers dissolved in bodily secretions which help to identify kin, conspecifics, and predators in the animal‟s environment. Although a growing body of evidence over the last two decades has revealed a very important role for the VNS in many stereotypical behaviors which are essential to the animal‟s survival, our understanding of the detailed organization of the circuitry of this system, and its development, remains limited. Consequently, the goal of this dissertation is to examine the development o
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20

Redolfi, Nelly. "Formation and function of neural circuitry in the olfactory bulb of mice with reduced afferent spontaneous activity." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423569.

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In the sensory systems, peripheral neurons project axons in specific loci of the brain. The spatial segregation of the sensory afferents provides topographic maps that define the quality and the location of complex sensory stimuli. Electrical activity plays a critical role in the formation of specific synaptic contacts among neurons, although the type of activity required remains a matter of significant debate. In particular the role of spontaneous activity in the formation of the topographic organization of the olfactory system remains unknown. To address this question we investigated th
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21

Chou, Wen-Chuang [Verfasser], Marc [Akademischer Betreuer] Timme, and André [Akademischer Betreuer] Fiala. "Computational modeling of neuronal circuits: heterogeneous connectivity and nonlinear transformation in olfactory processing / Wen-Chuang Chou. Gutachter: Marc Timme ; André Fiala. Betreuer: Marc Timme." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/107068614X/34.

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22

Böhm, Erik [Verfasser], Markus [Akademischer Betreuer] Rothermel, and Björn M. [Akademischer Betreuer] Kampa. "Cholinergic and GABAergic neuromodulatory basal forebrain projections differentially influence early sensory circuits in the mouse olfactory bulb / Erik Böhm ; Markus Rothermel, Björn M. Kampa." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1227992068/34.

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23

Aso, Yoshinori. "Dissecting the neuronal circuit for olfactory learning in Drosophila." Doctoral thesis, 2010. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-55483.

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This thesis consists of three major chapters, each of which has been separately published or under the process for publication. The first chapter is about anatomical characterization of the mushroom body of adult Drosophila melanogaster. The mushroom body is the center for olfactory learning and many other functions in the insect brains. The functions of the mushroom body have been studied by utilizing the GAL4/UAS gene expression system. The present study characterized the expression patterns of the commonly used GAL4 drivers for the mushroom body intrinsic neurons, Kenyon cells. Thereby, we
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24

Costantini, Daniel. "Neuronal Topography in a Cortical Circuit for Innate Odor Valence." Thesis, 2020. https://doi.org/10.7916/d8-ryea-m313.

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The mouse olfactory system detects odorants with 1000 olfactory receptors (ORs). Olfactory sensory neurons (OSNs) express only 1 OR. OSNs expressing a common OR converge on a single glomerulus, a stereotyped location in the olfactory bulb (OB). Thus, odorants are represented by a spatial map of glomerular activation. OB odor representations are then processed by five central brain regions. One region, cortical amygdala (CoA), receives spatially patterned and stereotyped axonal input from the OB and is both necessary and sufficient for innate behavioral responses to odor. However, CoA receives
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25

Aso, Yoshinori [Verfasser]. "Dissecting the neuronal circuit for olfactory learning in Drosophila / vorgelegt von Yoshinori Aso." 2010. http://d-nb.info/1011027887/34.

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26

Jayaraman, Vivek. "Neural circuit dynamics and ensemble coding in the locust and fruit fly olfactory system." Thesis, 2007. https://thesis.library.caltech.edu/1877/1/VivekJayaramanPhDThesis.pdf.

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<p>Raw sensory information is usually processed and reformatted by an organism’s brain to carry out tasks like identification, discrimination, tracking and storage. The work presented in this dissertation focuses on the processing strategies of neural circuits in the early olfactory system in two insects, the locust and the fruit fly. </p> <p> Projection neurons (PNs) in the antennal lobe (AL) respond to an odor presented to the locust’s antennae by firing in slow information-carrying temporal patterns, consistent across trials. Their downstream targets, the Kenyon cells (KCs) of the mushroom
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27

Romeas, Thomas. "Changements dans le circuit de la récompense suite à la bulbectomie olfactive : une nouvelle approche pour étudier des antidépresseurs." Thèse, 2009. http://hdl.handle.net/1866/2975.

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La dépression est une maladie chronique, récurrente et potentiellement mortelle qui affecte plus de 20 % de la population à travers le monde. Les mécanismes sous-jacents de la dépression demeurent incompris et la pharmacothérapie actuelle, largement basée sur l’hypothèse monoaminergique, fait preuve d’une efficacité sous optimale et d’une latence thérapeutique élevée. Par conséquent, la recherche est amenée à élaborer de nouveaux traitements pharmacologiques. Pour détecter leur action, il est avant tout nécessaire de développer des outils expérimentaux adéquats. Dans cette optique, notre but a
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28

Gore, Felicity May. "Neural circuits mediating innate and learned behavior." Thesis, 2015. https://doi.org/10.7916/D84Q7TQH.

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For many organisms the sense of smell is critical to survival. Some olfactory stimuli elicit innate responses that are mediated through hardwired circuits that have developed over long periods of evolutionary time. Most olfactory stimuli, however, have no inherent meaning. Instead, meaning must be imposed by learning during the lifetime of an organism. Despite the dominance of olfactory stimuli on animal behavior, the mechanisms by which odorants elicit learned behavioral responses remain poorly understood. All odor-evoked behaviors are initiated by the binding of an odorant to olfactory recep
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29

Mountoufaris, George. "The Role of the Clustered Protocadherins in the Assembly of Olfactory Neural Circuits." Thesis, 2016. https://doi.org/10.7916/D89K4BBT.

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The clustered protocadherins (Pcdh α, β & γ) provide individual neurons with cell surface diversity. However, the importance of Pcdh mediated diversity in neural circuit assembly and how it may promote neuronal connectivity remains largely unknown. Moreover, to date, Pcdh in vivo function has been studied at the level of individual gene clusters; whole cluster-wide function has not been addressed. Here I examine the role of all three Pcdh gene clusters in olfactory sensory neurons (OSNs); a neuronal type that expressed all three types of Pcdhs and in addition I address the role of Pcdh mediate
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30

Chou, Wen-Chuang. "Computational modeling of neuronal circuits: heterogeneous connectivity and nonlinear transformation in olfactory processing." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5FCE-A.

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31

Thum, Andreas Stephan [Verfasser]. "Sugar reward learning in Drosophila : neuronal circuits in Drosophila associative olfactory learning / vorgelegt von Andreas Stephan Thum." 2006. http://d-nb.info/980586771/34.

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32

Wang, Yiliu. "Imposing structure on odor representations during learning in the prefrontal cortex." Thesis, 2019. https://doi.org/10.7916/d8-vnwq-8d62.

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Animals have evolved sensory systems that afford innate and adaptive responses to stimuli in the environment. Innate behaviors are likely to be mediated by hardwired circuits that respond to invariant predictive cues over long periods of evolutionary time. However, most stimuli do not have innate value. Over the lifetime of an animal, learning provides a mechanism for animals to update the predictive value of cues through experience. Sensory systems must therefore generate neuronal representations that are able to acquire value through learning. A fundamental challenge in neuroscience is to un
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33

Butcher, Nancy J. "THE SYNAPTIC CIRCUITS UNDERLYING OLFACTORY PROCESSING AND REPRESENTATIONS IN THE INSECT BRAIN: CHARACTERIZATION AND PLASTICITY OF THE MUSHROOM BODY CALYX." 2010. http://hdl.handle.net/10222/13018.

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Sensory information is processed and encoded by neural networks. In order to understand how the nervous system is able to rapidly integrate and store sensory information, knowledge of the connections and properties of the neurons in these circuits is required. The fruit fly Drosophila melanogaster provides a particularly powerful species to investigate the neural circuits of the olfactory system because in addition to possessing a simple olfactory system amenable to circuit analysis, a host of genetic reagents are available, including the GAL4-UAS system for targeted gene expression. The mu
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34

Tabor, Rico [Verfasser]. "Pharmacological analysis of ionotropic glutamate and GABA receptor function in neuronal circuits of the zebrafish olfactory bulb / vorgelegt von Rico Tabor." 2008. http://d-nb.info/988457288/34.

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