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Zeitschriftenartikel zum Thema „Nuclear disruption“

Autor: Grafiati

Veröffentlicht am 25. Mai 2024

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1

Riccardo, V., and JET EFDA contributors. "Disruptions and disruption mitigation." Plasma Physics and Controlled Fusion 45, no. 12A (2003): A269—A284. http://dx.doi.org/10.1088/0741-3335/45/12a/018.

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2

Aymerich, E., G. Sias, F. Pisano, et al. "Disruption prediction at JET through deep convolutional neural networks using spatiotemporal information from plasma profiles." Nuclear Fusion 62, no. 6 (2022): 066005. http://dx.doi.org/10.1088/1741-4326/ac525e.

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Abstract In view of the future high power nuclear fusion experiments, the early identification of disruptions is a mandatory requirement, and presently the main goal is moving from the disruption mitigation to disruption avoidance and control. In this work, a deep-convolutional neural network (CNN) is proposed to provide early detection of disruptive events at JET. The CNN ability to learn relevant features, avoiding hand-engineered feature extraction, has been exploited to extract the spatiotemporal information from 1D plasma profiles. The model is trained with regularly terminated discharges

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Thornton, J. W. "Nonmammalian nuclear receptors: Evolution and endocrine disruption." Pure and Applied Chemistry 75, no. 11-12 (2003): 1827–39. http://dx.doi.org/10.1351/pac200375111827.

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Most research to identify endocrine-disrupting chemicals and their impacts has relied on mammalian models or in vitro systems derived from them. But nuclear receptors (NRs), the proteins that transduce hydrophobic hormonal signals and are major mediators of endocrine disruption, emerged early in animal evolution and now play biologically essential roles throughout the Metazoa. Nonmammalian vertebrates and invertebrates, many of which are of considerable ecological, economic, and cultural importance, are therefore potentially subject to endocrine disruption by synthetic environmental pollutants

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Yang, Zongyu, Fan Xia, Xianming Song, Zhe Gao, Shuo Wang, and Yunbo Dong. "In-depth research on the interpretable disruption predictor in HL-2A." Nuclear Fusion 61, no. 12 (2021): 126042. http://dx.doi.org/10.1088/1741-4326/ac31d8.

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Abstract In-depth research is implemented on the disruption predictor in HL-2A to improve the accuracy and interpretability of the model. For higher accuracy, four adjustments are tried to solve four corresponding problems in a baseline model. Reductive comparison experiments are designed to evaluate their contribution to performance. The result shows that these adjustments together can improve the AUC (area under receiver operating characteristic curve) of the baseline model by 0.039. For interpretability of model, an interpretation method is proposed to evaluate the real-time importance of e

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Fyfe, Ian. "TDP pathology leads to nuclear disruption." Nature Reviews Neurology 14, no. 3 (2018): 127. http://dx.doi.org/10.1038/nrneurol.2018.2.

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6

Wie, B. "Hypervelocity nuclear interceptors for asteroid disruption." Acta Astronautica 90, no. 1 (2013): 146–55. http://dx.doi.org/10.1016/j.actaastro.2012.04.028.

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7

Furukawa, Manabu, Yanping Zhang, Joseph McCarville, Tomohiko Ohta, and Yue Xiong. "The CUL1 C-Terminal Sequence and ROC1 Are Required for Efficient Nuclear Accumulation, NEDD8 Modification, and Ubiquitin Ligase Activity of CUL1." Molecular and Cellular Biology 20, no. 21 (2000): 8185–97. http://dx.doi.org/10.1128/mcb.20.21.8185-8197.2000.

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ABSTRACT Members of the cullin and RING finger ROC protein families form heterodimeric complexes to constitute a potentially large number of distinct E3 ubiquitin ligases. We report here that the highly conserved C-terminal sequence in CUL1 is dually required, both for nuclear localization and for modification by NEDD8. Disruption of ROC1 binding impaired nuclear accumulation of CUL1 and decreased NEDD8 modification in vivo but had no effect on NEDD8 modification of CUL1 in vitro, suggesting that ROC1 promotes CUL1 nuclear accumulation to facilitate its NEDD8 modification. Disruption of NEDD8

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Clark-Walker, G. D., and X. J. Chen. "Dual Mutations Reveal Interactions Between Components of Oxidative Phosphorylation in Kluyveromyces lactis." Genetics 159, no. 3 (2001): 929–38. http://dx.doi.org/10.1093/genetics/159.3.929.

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Abstract Loss of mtDNA or mitochondrial protein synthesis cannot be tolerated by wild-type Kluyveromyces lactis. The mitochondrial function responsible for ρ0-lethality has been identified by disruption of nuclear genes encoding electron transport and F0-ATP synthase components of oxidative phosphorylation. Sporulation of diploid strains heterozygous for disruptions in genes for the two components of oxidative phosphorylation results in the formation of nonviable spores inferred to contain both disruptions. Lethality of spores is thought to result from absence of a transmembrane potential, ΔΨ,

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Ohkawa, Taro, and Matthew D. Welch. "Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress." Current Biology 28, no. 13 (2018): 2153–59. http://dx.doi.org/10.1016/j.cub.2018.05.027.

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10

Spann, Timothy P., Anne E. Goldman, Chen Wang, Sui Huang, and Robert D. Goldman. "Alteration of nuclear lamin organization inhibits RNA polymerase II–dependent transcription." Journal of Cell Biology 156, no. 4 (2002): 603–8. http://dx.doi.org/10.1083/jcb.200112047.

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RTegulation of gene activity is mediated by alterations in chromatin organization. In addition, chromatin organization may be governed in part by interactions with structural components of the nucleus. The nuclear lamins comprise the lamina and a variety of nucleoplasmic assemblies that together are major structural components of the nucleus. Furthermore, lamins and lamin-associated proteins have been reported to bind chromatin. These observations suggest that the nuclear lamins may be involved in the regulation of gene activity. In this report, we test this possibility by disrupting the norma

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11

Mockler, Brenna, Angela A. Twum, Katie Auchettl, et al. "Evidence for the Preferential Disruption of Moderately Massive Stars by Supermassive Black Holes." Astrophysical Journal 924, no. 2 (2022): 70. http://dx.doi.org/10.3847/1538-4357/ac35d5.

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Abstract Tidal disruption events (TDEs) provide a unique opportunity to probe the stellar populations around supermassive black holes (SMBHs). By combining light-curve modeling with spectral line information and knowledge about the stellar populations in the host galaxies, we are able to constrain the properties of the disrupted star for three TDEs. The TDEs in our sample have UV spectra, and measurements of the UV N iii to C iii line ratios enabled estimates of the nitrogen-to-carbon abundance ratios for these events. We show that the measured nitrogen line widths are consistent with originat

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Liang, Jiali, Marc Ernoult, Xavier Doligez, Sylvain David, Léa Tillard, and Nicolas Thiollière. "Robustness Study of Electro-Nuclear Scenario under Disruption." Journal of Nuclear Engineering 2, no. 1 (2021): 1–8. http://dx.doi.org/10.3390/jne2010001.

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As the future of nuclear power is uncertain, only choosing one development objective for the coming decades can be risky; while trying to achieve several possible objectives at the same time may lead to a deadlock due to contradiction among them. In this work, we study a simple scenario to illustrate the newly developed method of robustness study, which considers possible change of objectives. Starting from the current French fleet, two objectives are considered regarding the possible political choices for the future of nuclear power: A. Complete substitution of Pressurized Water Reactors by S

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Melo, Sonia A., and Manel Esteller. "Disruption of microRNA nuclear transport in human cancer." Seminars in Cancer Biology 27 (August 2014): 46–51. http://dx.doi.org/10.1016/j.semcancer.2014.02.012.

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14

Razafsky, David, Shulun Zang, and Didier Hodzic. "UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning." Biochemical Society Transactions 39, no. 6 (2011): 1790–94. http://dx.doi.org/10.1042/bst20110660.

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Appropriate tissue morphogenesis strictly requires the developmental regulation of different types of nuclear movements. LINC (linker of nucleoskeleton and cytoskeleton) complexes are macromolecular scaffolds that span the nuclear envelope and physically connect the nuclear interior to different cytoskeletal elements and molecular motors, thereby playing essential roles in nucleokinesis. Recent studies dedicated to the in vivo disruption of LINC complexes not only confirmed their widespread role in nuclear dynamics, but also led to a vigorous regain of interest in the physiological relevance o

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Mattila, S., M. J. Graham, E. Kankare, et al. "Nuclear Transients." Proceedings of the International Astronomical Union 14, S339 (2017): 263–68. http://dx.doi.org/10.1017/s1743921318002727.

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AbstractWorkshop 11 covered the substantial recent progress in studies of supernovæ (SNe), tidal disruption events (TDEs), and other types of luminous transients occurring within the nuclear regions of galaxies. In the past, such transients have largely been missed owing to the substantial extinction of those regions, and to the problems of contrast against the bright (and often complex) nuclear background – or mistaken for normal active galactic nucleus (AGN) variability.

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Lane, Cynthia M., Ian Cushman, and Mary Shannon Moore. "Selective Disruption of Nuclear Import by a Functional Mutant Nuclear Transport Carrier." Journal of Cell Biology 151, no. 2 (2000): 321–32. http://dx.doi.org/10.1083/jcb.151.2.321.

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p10/NTF2 is a nuclear transport carrier that mediates the uptake of cytoplasmic RanGDP into the nucleus. We constructed a point mutant of p10, D23A, that exhibited unexpected behavior both in digitonin-permeabilized and microinjected mammalian cells. D23A p10 was markedly more efficient than wild-type (wt) p10 at supporting Ran import, but simultaneously acted as a dominant-negative inhibitor of classical nuclear localization sequence (cNLS)-mediated nuclear import supported by karyopherins (Kaps) α and β1. Binding studies indicated that these two nuclear transport carriers of different classe

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Shahin, Victor. "Strategic disruption of nuclear pores structure, integrity and barrier for nuclear apoptosis." Seminars in Cell & Developmental Biology 68 (August 2017): 85–90. http://dx.doi.org/10.1016/j.semcdb.2017.07.002.

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18

Ma, Hong, Alan J. Siegel, and Ronald Berezney. "Association of Chromosome Territories with the Nuclear Matrix." Journal of Cell Biology 146, no. 3 (1999): 531–42. http://dx.doi.org/10.1083/jcb.146.3.531.

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To study the possible role of the nuclear matrix in chromosome territory organization, normal human fibroblast cells are treated in situ via classic isolation procedures for nuclear matrix in the absence of nuclease (e.g., DNase I) digestion, followed by chromosome painting. We report for the first time that chromosome territories are maintained intact on the nuclear matrix. In contrast, complete extraction of the internal nuclear matrix components with RNase treatment followed by 2 M NaCl results in the disruption of higher order chromosome territory architecture. Correlative with territorial

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19

Zhou, Zheng, Jaclyn M. Goodrich, and Rita S. Strakovsky. "Mitochondrial Epigenetics and Environmental Health: Making a Case for Endocrine Disrupting Chemicals." Toxicological Sciences 178, no. 1 (2020): 16–25. http://dx.doi.org/10.1093/toxsci/kfaa129.

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Abstract Recent studies implicate mitochondrial dysfunction in the development and progression of numerous chronic diseases, which may be partially due to modifications in mitochondrial DNA (mtDNA). There is also mounting evidence that epigenetic modifications to mtDNA may be an additional layer of regulation that controls mitochondrial biogenesis and function. Several environmental factors (eg, smoking, air pollution) have been associated with altered mtDNA methylation in a handful of mechanistic studies and in observational human studies. However, little is understood about other environment

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Boyer, M. D., C. Rea, and M. Clement. "Toward active disruption avoidance via real-time estimation of the safe operating region and disruption proximity in tokamaks." Nuclear Fusion 62, no. 2 (2021): 026005. http://dx.doi.org/10.1088/1741-4326/ac359e.

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Abstract This paper describes a real-time capable algorithm for identifying the safe operating region around a tokamak operating point. The region is defined by a convex set of linear constraints, from which the distance of a point from a disruptive boundary can be calculated. The disruptivity of points is calculated from an empirical machine learning predictor that generates the likelihood of disruption. While the likelihood generated by such empirical models can be compared to a threshold to trigger a disruption mitigation system, the safe operating region calculation enables active optimiza

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I. Simunic, David, Neil D. Broom, and Peter A. Robertson. "Biomechanical Factors Influencing Nuclear Disruption of the Intervertebral Disc." Spine 26, no. 11 (2001): 1223–30. http://dx.doi.org/10.1097/00007632-200106010-00010.

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22

Dube, Thembalami, Christina A. Rabeler, and Dawn Carone. "In vivo disruption of nuclear HSATII RNA biomolecular condensates." Biophysical Journal 122, no. 3 (2023): 486a—487a. http://dx.doi.org/10.1016/j.bpj.2022.11.2601.

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23

Clarke, Teagan A., Lani Chastain, Paul D. Lasky, and Eric Thrane. "Nuclear Physics with Gravitational Waves from Neutron Stars Disrupted by Black Holes." Astrophysical Journal Letters 949, no. 1 (2023): L6. http://dx.doi.org/10.3847/2041-8213/acd33b.

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Abstract Gravitational waves from neutron star–black hole (NSBH) mergers that undergo tidal disruption provide a potential avenue to study the equation of state of neutron stars and hence the behavior of matter at its most extreme densities. We present a phenomenological model for the gravitational-wave signature of tidal disruption, which allows us to measure the disruption time. We carry out a study with mock data, assuming an optimistically nearby NSBH event with parameters tuned for measuring the tidal disruption. We show that a two-detector network of 40 km Cosmic Explorer instruments can

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Swedenborg, Elin, Joëlle Rüegg, Sari Mäkelä, and Ingemar Pongratz. "Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders." Journal of Molecular Endocrinology 43, no. 1 (2009): 1–10. http://dx.doi.org/10.1677/jme-08-0132.

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Endocrine disruption refers to the ability of chemicals to interfere with hormonal systems, and has raised considerable concern in recent years. Endocrine disruptive chemicals (EDCs) pose a documented risk to wildlife and have the potential to negatively influence human health. This review focuses on the molecular mechanisms of endocrine disruption and the possible involvement of EDCs in metabolic disorders. The first part describes the role of aryl hydrocarbon receptor (AhR) and nuclear receptors (NRs) in mediating effects of EDCs, in particular, how cross-talk between AhR and NR pathways can

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Moravcsik, Eva, Melanie Joannides, Edwige Voisset, et al. "Disruption Of PML Nuclear Bodies Cooperates In The Pathogenesis Of Acute Promyelocytic Leukemia." Blood 122, no. 21 (2013): 3721. http://dx.doi.org/10.1182/blood.v122.21.3721.3721.

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Abstract Acute promyelocytic leukemia (APL) is characterised by the t(15;17)(q22;q21) leading to fusion of PML to the gene encoding the myeloid transcription factor Retinoic Acid Receptor α (RARα). Chromosomal translocations such as the t(15;17) are considered to be initiating events in leukemogenesis; however, sequencing of APL genomes has provided further evidence that the PML-RARα fusion is insufficient to induce leukemia, which depends upon the acquisition of cooperating mutations. The PML-RARα oncoprotein exerts a profound effect on nuclear architecture, disrupting multiprotein structures

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Ryu, Taeho, Rosalba Perna, and Matteo Cantiello. "Tidal Disruption Encores." Astrophysical Journal Letters 965, no. 2 (2024): L25. http://dx.doi.org/10.3847/2041-8213/ad3946.

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Abstract Nuclear star clusters (NSCs), made up of a dense concentration of stars and the compact objects they leave behind, are ubiquitous in the central regions of galaxies surrounding the central supermassive black hole (SMBH). Close interactions between stars and stellar-mass black holes (sBHs) lead to tidal disruption events (TDEs). We uncover an interesting new phenomenon: for a subset of these, the unbound debris (to the sBH) remains bound to the SMBH, accreting at a later time, thus giving rise to a second flare. We compute the rate of such events and find them ranging within 10−6–10−3

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Morrissette, Naomi S., and L. David Sibley. "Disruption of microtubules uncouples budding and nuclear division inToxoplasma gondii." Journal of Cell Science 115, no. 5 (2002): 1017–25. http://dx.doi.org/10.1242/jcs.115.5.1017.

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The tachyzoite stage of the protozoan parasite Toxoplasma gondiihas two populations of microtubules: spindle microtubules and subpellicular microtubules. To determine how these two microtubule populations are regulated, we investigated microtubule behavior during the cell cycle following treatment with microtubule-disrupting drugs. Previous work had established that the microtubule populations are individually nucleated by two distinct microtubule-organizing centers (MTOCs): the apical polar ring for the subpellicular microtubules and spindle pole plaques/centrioles for the spindle microtubule

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Gezari, Suvi. "Tidal Disruption Events." Annual Review of Astronomy and Astrophysics 59, no. 1 (2021): 21–58. http://dx.doi.org/10.1146/annurev-astro-111720-030029.

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The concept of stars being tidally ripped apart and consumed by a massive black hole (MBH) lurking in the center of a galaxy first captivated theorists in the late 1970s. The observational evidence for these rare but illuminating phenomena for probing otherwise dormant MBHs first emerged in archival searches of the soft X-ray ROSAT All-Sky Survey in the 1990s, but has recently accelerated with the increasing survey power in the optical time domain, with tidal disruption events (TDEs) now regarded as a class of optical nuclear transients with distinct spectroscopic features. Multiwavelength obs

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Zhong, Shiyan, Shuo Li, Peter Berczik, and Rainer Spurzem. "Revisit the Rate of Tidal Disruption Events: The Role of the Partial Tidal Disruption Event." Astrophysical Journal 933, no. 1 (2022): 96. http://dx.doi.org/10.3847/1538-4357/ac71ad.

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Abstract Tidal disruption of stars in dense nuclear star clusters containing supermassive central black holes (SMBH) is modeled by high-accuracy direct N-body simulation. Stars getting too close to the SMBH are tidally disrupted, and a tidal disruption event (TDE) happens. The TDEs probe the properties of SMBHs, their accretion disks, and the surrounding nuclear stellar cluster. In this paper, we compare the rates of full tidal disruption events (FTDEs) with partial tidal disruption events (PTDEs). Since a PTDE does not destroy the star, a leftover object emerges; we use the term “leftover sta

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Li, Su-Ting T., and Alexander B. Baxter. "Traumatic Ossicular Disruption." American Journal of Roentgenology 174, no. 5 (2000): 1296. http://dx.doi.org/10.2214/ajr.174.5.1741296.

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31

Leach, Natalie, Susan L. Bjerke, Desire K. Christensen, et al. "Emerin Is Hyperphosphorylated and Redistributed in Herpes Simplex Virus Type 1-Infected Cells in a Manner Dependent on both UL34 and US3." Journal of Virology 81, no. 19 (2007): 10792–803. http://dx.doi.org/10.1128/jvi.00196-07.

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ABSTRACT Cells infected with wild-type herpes simplex virus type 1 (HSV-1) show disruption of the organization of the nuclear lamina that underlies the nuclear envelope. This disruption is reflected in changes in the localization and phosphorylation of lamin proteins. Here, we show that HSV-1 infection causes relocalization of the LEM domain protein emerin. In cells infected with wild-type virus, emerin becomes more mobile in the nuclear membrane, and in cells infected with viruses that fail to express UL34 protein (pUL34) and US3 protein (pUS3), emerin no longer colocalizes with lamins, sugge

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KUSTERMANS, Gaelle, Jamel EL BENNA, Jacques PIETTE та Sylvie LEGRAND-POELS. "Perturbation of actin dynamics induces NF-κB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway". Biochemical Journal 387, № 2 (2005): 531–40. http://dx.doi.org/10.1042/bj20041318.

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Although several reports showed the effect of compounds disrupting microtubules on NF-κB (nuclear factor κB) activation, nothing is known about agents perturbing actin dynamics. In the present study, we have shown that actin cytoskeleton disruption induced by actin-depolymerizing agents such as cytochalasin D and latrunculin B and actin-polymerizing compounds such as jasplakinolide induced NF-κB activation in myelomonocytic cells. The transduction pathway involved the IκB (inhibitory κB) kinase complex and a degradation of IκBα. We have shown that NF-κB activation in response to the perturbati

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Hamilton, Bruce A., Wayne N. Frankel, Anne W. Kerrebrock та ін. "Disruption of the nuclear hormone receptor RORα in staggerer mice". Nature 379, № 6567 (1996): 736–39. http://dx.doi.org/10.1038/379736a0.

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Grün, Felix, and Bruce Blumberg. "Environmental Obesogens: Organotins and Endocrine Disruption via Nuclear Receptor Signaling." Endocrinology 147, no. 6 (2006): s50—s55. http://dx.doi.org/10.1210/en.2005-1129.

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35

Abella, Neus, Sonia Brun, Maria Calvo, et al. "Nucleolar Disruption Ensures Nuclear Accumulation of p21 upon DNA Damage." Traffic 11, no. 6 (2010): 743–55. http://dx.doi.org/10.1111/j.1600-0854.2010.01063.x.

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Balaguer, Patrick, Vanessa Delfosse, and William Bourguet. "Mechanisms of endocrine disruption through nuclear receptors and related pathways." Current Opinion in Endocrine and Metabolic Research 7 (August 2019): 1–8. http://dx.doi.org/10.1016/j.coemr.2019.04.008.

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37

Kelly, C., R. Van Driel, and G. W. G. Wilkinson. "Disruption of PML-associated nuclear bodies during human cytomegalovirus infection." Journal of General Virology 76, no. 11 (1995): 2887–93. http://dx.doi.org/10.1099/0022-1317-76-11-2887.

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38

Jachmich, S., U. Kruezi, M. Lehnen, et al. "Shattered pellet injection experiments at JET in support of the ITER disruption mitigation system design." Nuclear Fusion 62, no. 2 (2021): 026012. http://dx.doi.org/10.1088/1741-4326/ac3c86.

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Abstract A series of experiments have been executed at JET to assess the efficacy of the newly installed shattered pellet injection (SPI) system in mitigating the effects of disruptions. Issues, important for the ITER disruption mitigation system, such as thermal load mitigation, avoidance of runaway electron (RE) formation, radiation asymmetries during thermal quench mitigation, electromagnetic load control and RE energy dissipation have been addressed over a large parameter range. The efficiency of the mitigation has been examined for the various SPI injection strategies. The paper summarise

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Wu, Li-Ying, Chia-Lin Han, Hsi-Hui Lin, and Ming-Jer Tang. "Ha-RasV12-Induced Multilayer Cellular Aggregates Is Mediated by Rac1 Activation Rather Than YAP Activation." Biomedicines 10, no. 5 (2022): 977. http://dx.doi.org/10.3390/biomedicines10050977.

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We demonstrate that Ha-RasV12 overexpression induces the nuclear translocation of Hippo effector Yes-associated protein (YAP) in MDCK cells via the hippo-independent pathway at the confluent stage. Ha-RasV12 overexpression leads to the downregulation of Caveolin-1 (Cav1) and the disruption of junction integrity. It has been shown that the disruption of actin belt integrity causes YAP nuclear translocation in epithelial cells at high density. Therefore, we hypothesized that Ha-RasV12-decreased Cav1 leads to the disruption of cell junction integrity, which subsequently facilitates YAP nuclear re

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Anantharaju, Abhinandana, Ahmad Cheema, David H. Van Thiel, and Jack Leya. "Complete esophagogastric anastomotic disruption." Gastrointestinal Endoscopy 57, no. 7 (2003): 921. http://dx.doi.org/10.1016/s0016-5107(03)70034-0.

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41

Moir, Robert D., Timothy P. Spann, Harald Herrmann, and Robert D. Goldman. "Disruption of Nuclear Lamin Organization Blocks the Elongation Phase of DNA Replication." Journal of Cell Biology 149, no. 6 (2000): 1179–92. http://dx.doi.org/10.1083/jcb.149.6.1179.

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The role of nuclear lamins in DNA replication is unclear. To address this, nuclei were assembled in Xenopus extracts containing AraC, a reversible inhibitor that blocks near the onset of the elongation phase of replication. Dominant-negative lamin mutants lacking their NH2-terminal domains were added to assembled nuclei to disrupt lamin organization. This prevented the resumption of DNA replication after the release of the AraC block. This inhibition of replication was not due to gross disruption of nuclear envelope structure and function. The organization of initiation factors was not altered

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Kankare, E., R. Kotak, S. Mattila, and P. Lundqvist. "A New Population of Highly Energetic Nuclear Transients." Proceedings of the International Astronomical Union 14, S339 (2017): 131–34. http://dx.doi.org/10.1017/s1743921318002387.

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AbstractWe have identified a new population of luminous, optical, narrow-lined transients (FWHM ∼1000 km s−1) coincident with the nuclear region of Seyfert galaxies. According to extensive spectrophotometric follow-ups of the main event (PS1-10adi), we could exclude both normal active galactic nucleus activity and changing-look quasars as the origin. The integrated energy output and spectral evolution over a time-scale of several years point to two possible paths of origin: a tidal disruption of a star by a supermassive black hole, or an extremely energetic supernova occurring within the Seyfe

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Voisset, Edwige, Eva Moravcsik, Eva W. Stratford, et al. "Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice." Blood 131, no. 6 (2018): 636–48. http://dx.doi.org/10.1182/blood-2017-07-794784.

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Key Points A novel mouse model elucidates the impact of Pml NB disruption on APL pathogenesis and response to targeted therapy. The mode of action of this disruption appears to be via the perturbation of the NHEJ and HR pathways.

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Woyke, Tanja, Robert W. Roberson, George R. Pettit, Günther Winkelmann, and Robin K. Pettit. "Effect of Auristatin PHE on Microtubule Integrity and Nuclear Localization in Cryptococcus neoformans." Antimicrobial Agents and Chemotherapy 46, no. 12 (2002): 3802–8. http://dx.doi.org/10.1128/aac.46.12.3802-3808.2002.

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ABSTRACT The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear localization in auristatin PHE-treated cells were examined. Iterative deconvolution in conjunction with an optimized C. neoformans microtubule immunolabeling procedure enabled detailed visualization of the microtubule cytoskeleton in auristatin PHE-treated C. neoformans. The ef

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Sivachandran, Nirojini, Feroz Sarkari, and Lori Frappier. "Epstein-Barr Nuclear Antigen 1 Contributes to Nasopharyngeal Carcinoma through Disruption of PML Nuclear Bodies." PLoS Pathogens 4, no. 10 (2008): e1000170. http://dx.doi.org/10.1371/journal.ppat.1000170.

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Shani, Vered, Hazem Safory, Raymonde Szargel, et al. "Physiological and pathological roles of LRRK2 in the nuclear envelope integrity." Human Molecular Genetics 28, no. 23 (2019): 3982–96. http://dx.doi.org/10.1093/hmg/ddz245.

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Abstract Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolog (SIAH-1), and in the nucleus it directly interacts with lamin A/C, independent of its kinase activity. LRRK2 knockdown caused nuclear lamina abnormalities and nuclear disruption. LRRK2 disease mutations mostly abolish the interaction with lamin A/C and, similar to LRRK2 knockdown, cause disorganization of lamin A/C and leakage of nuclear p

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Park, Ji-Hwan, Sung Jin Ryu, Byung Ju Kim, et al. "Disruption of nucleocytoplasmic trafficking as a cellular senescence driver." Experimental & Molecular Medicine 53, no. 6 (2021): 1092–108. http://dx.doi.org/10.1038/s12276-021-00643-6.

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AbstractSenescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This diminished reaction may be explained by the disrupted transmission of nuclear signals. However, this hypothesis requires more evidence before it can be accepted as a mechanism of cellular senescence. A proteomic analysis of the cytoplasmic and nuclear fractions obtained from young and senescent cells revealed disruption of nucleocytoplasmic trafficking (NCT) as an essential feature of replicative senescence (RS) at the global level. Blocking NCT either chemically or genetically induced the acquisition o

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Beck, Samuel, and Junyeong Lee. "DISRUPTION OF CPG ISLAND-MEDIATED CHROMATIN ARCHITECTURE AND TRANSCRIPTIONAL HOMEOSTASIS DURING AGING." Innovation in Aging 3, Supplement_1 (2019): S208. http://dx.doi.org/10.1093/geroni/igz038.756.

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Abstract Aging causes the global disorganization of nuclear chromatin architecture. In a normal young nucleus, silent heterochromatin is associated with the nuclear lamina layer underlying nuclear envelope, thus spatially separated from euchromatin at the nuclear center. Notably, aging causes the disruption of nuclear lamina and the decondensation of associated heterochromatin. However, it is not clearly understood how these changes of chromatin architectures contribute to age-related diseases. Through large-scale computational analyses, we present that CpG islands (CGIs) give important clues

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Di Micco, Antonia, Gianluca Frera, Jérôme Lugrin, et al. "AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity." Proceedings of the National Academy of Sciences 113, no. 32 (2016): E4671—E4680. http://dx.doi.org/10.1073/pnas.1602419113.

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Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV aspartyl protease, Nelfinavir, triggers inflammasome formation and elicits an IL-1R–dependent inflammation in mice. We found that Nelfinavir impaired the maturation of lamin A, a structural component of the nuclear envelope, thereby promoting the release of DNA in the cytosol. Moreover, deficiency of

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Fiocchetti, Marco, Giovanna Bastari, Manuela Cipolletti, Stefano Leone, Filippo Acconcia та Maria Marino. "The Peculiar Estrogenicity of Diethyl Phthalate: Modulation of Estrogen Receptor α Activities in the Proliferation of Breast Cancer Cells". Toxics 9, № 10 (2021): 237. http://dx.doi.org/10.3390/toxics9100237.

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Phthalates comprise a group of synthetic chemicals present in the environment because of their wide use as plasticizers and as additives in products for personal care. Among others, diethyl phthalate (DEP) is largely used in products for infants, children, and adults, in which its exposure has been correlated with an increased risk of breast cancer. The adverse health outcomes deriving from phthalate exposure have been associated with their activity as endocrine disruptors (EDCs) of the steroid and thyroid hormone signaling by affecting developmental and reproductive health, and even carcinoge

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